| Symbol | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| ITOS | See remarks | Aug 23, 2023 | Sale | $16.26 | 350,000 | 5,692,673 | 2,119,212 | Aug 25, 2023, 09:28 PM |
| MRTX | See remarks | Aug 11, 2023 | Buy | $27.80 | 1,201,440 | 33,400,031 | 3,201,440 | Aug 15, 2023, 09:39 PM |
| MRTX | See remarks | Aug 11, 2023 | Buy | $27.80 | 57,533 | 1,599,417 | 287,866 | Aug 15, 2023, 09:39 PM |
| MRTX | See remarks | Aug 11, 2023 | Buy | $27.80 | 1,201,440 | 33,400,031 | 3,201,440 | Aug 15, 2023, 09:38 PM |
| MRTX | See remarks | Aug 11, 2023 | Buy | $27.80 | 57,533 | 1,599,417 | 287,866 | Aug 15, 2023, 09:38 PM |
| TNGX | See remarks | Aug 11, 2023 | Buy | $5.15 | 475,000 | 2,446,250 | 743,542 | Aug 15, 2023, 09:34 PM |
| RAIN | See remarks. | May 22, 2023 | Sale | $1.25 | 995,000 | 1,243,750 | 1,152,212 | May 24, 2023, 08:05 PM |
| TYRA | 10% Owner | Feb 10, 2023 | Sale | $13.40 | 65,568 | 878,611 | 22,527 | Feb 13, 2023, 09:39 PM |
| TYRA | 10% Owner | Feb 09, 2023 | Sale | $13.10 | 200,000 | 2,620,000 | 88,095 | Feb 13, 2023, 09:39 PM |
| RAIN | Director | Nov 04, 2022 | Buy | $5.83 | 972,212 | 5,667,996 | 2,147,212 | Nov 08, 2022, 04:30 PM |
| TNGX | 10% Owner | Oct 13, 2022 | Buy | $4.65 | 70,000 | 325,227 | 7,123,642 | Oct 13, 2022, 09:30 PM |
| TNGX | 10% Owner | Oct 12, 2022 | Buy | $4.43 | 50,000 | 221,640 | 268,524 | Oct 13, 2022, 09:30 PM |
| TNGX | 10% Owner | Oct 11, 2022 | Buy | $4.25 | 117,000 | 497,706 | 218,524 | Oct 13, 2022, 09:30 PM |
| ITOS | Director | May 09, 2022 | Sale | $23.40 | 225,000 | 5,265,842 | 2,792,058 | May 11, 2022, 09:15 PM |
| ITOS | Director | May 11, 2022 | Sale | $18.25 | 338,000 | 6,167,422 | 2,491,167 | May 11, 2022, 09:15 PM |
| ITOS | Director | May 10, 2022 | Sale | $25.16 | 100,000 | 2,515,970 | 2,496,908 | May 11, 2022, 09:15 PM |
| ITOS | Director | May 02, 2022 | Sale | $27.49 | 100,000 | 2,748,734 | 2,909,758 | May 02, 2022, 09:15 PM |
| ITOS | Director | Apr 29, 2022 | Sale | $27.11 | 125,000 | 3,388,821 | 3,032,058 | May 02, 2022, 09:15 PM |
| ITOS | Director | Apr 28, 2022 | Sale | $27.40 | 150,000 | 4,110,315 | 3,042,058 | May 02, 2022, 09:15 PM |
| ITOS | Director | Mar 23, 2022 | Buy | $32.85 | 20,000 | 656,980 | 3,192,058 | Mar 24, 2022, 09:00 PM |
| ITOS | Director | Mar 22, 2022 | Buy | $32.28 | 30,000 | 968,509 | 3,172,058 | Mar 24, 2022, 09:00 PM |
| ITOS | Director | Jan 03, 2022 | Sale | $47.89 | 515,323 | 24,677,378 | 3,912,113 | Jan 05, 2022, 09:20 PM |
| ITOS | Director | Jan 04, 2022 | Sale | $42.77 | 184,677 | 7,898,264 | 3,767,405 | Jan 05, 2022, 09:20 PM |
| ODT | Director | Nov 19, 2021 | Sale | $1.84 | 150,000 | 276,285 | 4,607,086 | Nov 19, 2021, 07:22 PM |
| ODT | Director | Nov 19, 2021 | Sale | $1.92 | 30,000 | 57,495 | 445,756 | Nov 19, 2021, 07:22 PM |
| ODT | Director | Nov 18, 2021 | Sale | $1.95 | 250,000 | 487,250 | 4,757,086 | Nov 19, 2021, 07:22 PM |
| ODT | Director | Nov 17, 2021 | Sale | $2.17 | 600,000 | 1,299,240 | 5,007,086 | Nov 19, 2021, 07:22 PM |
| ODT | Director | Nov 17, 2021 | Sale | $2.23 | 170,000 | 379,678 | 475,756 | Nov 19, 2021, 07:22 PM |
| TYRA | 10% Owner | Sep 17, 2021 | Buy | $16.00 | 625,000 | 10,000,000 | 6,323,359 | Sep 17, 2021, 04:38 PM |
| MRTX | 10% Owner | Mar 05, 2021 | Option Exercise | $0.00 | 611,440 | 611 | 2,363,004 | Mar 09, 2021, 09:48 PM |
| MRTX | 10% Owner | Mar 05, 2021 | Sale | $181.15 | 400,005 | 72,460,903 | 2,363,000 | Mar 09, 2021, 09:48 PM |
| ODT | Director | Dec 30, 2020 | Buy | $17.46 | 100,000 | 1,746,380 | 5,607,086 | Dec 30, 2020, 06:18 PM |
| ODT | Director | Dec 29, 2020 | Buy | $17.11 | 225,000 | 3,849,548 | 5,507,086 | Dec 30, 2020, 06:18 PM |
| ODT | Director | Dec 28, 2020 | Buy | $16.90 | 75,000 | 1,267,500 | 5,282,086 | Dec 30, 2020, 06:18 PM |
| MRTX | 10% Owner | Oct 30, 2020 | Option Exercise | $219.97 | 3 | 660 | 1,765,560 | Oct 30, 2020, 09:54 PM |
| MRTX | 10% Owner | Oct 30, 2020 | Option Exercise | $0.00 | 400,003 | 400 | 1,765,562 | Oct 30, 2020, 09:54 PM |
| MRTX | 10% Owner | Oct 30, 2020 | Sale | $202.00 | 400,000 | 80,800,000 | 1,404,610 | Oct 30, 2020, 09:54 PM |
| ODT | Director | Sep 29, 2020 | Buy | $14.08 | 122,000 | 1,717,760 | 5,207,086 | Sep 30, 2020, 04:36 PM |
| ODT | Director | Sep 28, 2020 | Buy | $13.03 | 93,200 | 1,214,396 | 5,085,086 | Sep 30, 2020, 04:36 PM |
| PMVP | Former 10% Owner | Sep 25, 2020 | Buy | $18.00 | 950,000 | 17,100,000 | 950,000 | Sep 29, 2020, 04:40 PM |
| ODT | Director | Sep 08, 2020 | Buy | $14.69 | 18,800 | 276,172 | 4,910,786 | Sep 09, 2020, 05:59 PM |
| ODT | Director | Sep 04, 2020 | Buy | $14.89 | 125,100 | 1,862,739 | 4,891,986 | Sep 09, 2020, 05:59 PM |
| ODT | Director | Sep 09, 2020 | Buy | $15.20 | 81,100 | 1,232,720 | 4,991,886 | Sep 09, 2020, 05:59 PM |
| ODT | Director | Aug 28, 2020 | Buy | $14.25 | 1,403,509 | 20,000,003 | 4,766,886 | Sep 01, 2020, 04:30 PM |
| ITOS | Director | Jul 28, 2020 | Buy | $19.00 | 1,425,000 | 27,075,000 | 4,345,016 | Jul 30, 2020, 09:00 AM |
| PAND | 10% Owner | Jul 21, 2020 | Buy | $18.00 | 722,222 | 12,999,996 | 2,107,513 | Jul 21, 2020, 07:49 PM |
| MRTX | Director | Jan 07, 2019 | Sale | $46.40 | 40,000 | 1,855,803 | 70,409 | Jan 09, 2019, 09:31 PM |
| MRTX | Director | Jan 08, 2019 | Sale | $52.80 | 10,000 | 528,000 | 42,052 | Jan 09, 2019, 09:31 PM |
| ODT | Director | Dec 26, 2018 | Buy | $12.47 | 25,000 | 311,815 | 2,978,762 | Dec 27, 2018, 05:01 PM |
| ODT | Director | Dec 21, 2018 | Buy | $13.47 | 100,000 | 1,347,015 | 2,953,762 | Dec 27, 2018, 05:01 PM |
| ODT | Director | Oct 24, 2018 | Buy | $14.72 | 26,824 | 394,753 | 2,853,762 | Oct 26, 2018, 04:32 PM |
| ODT | Director | Mar 26, 2018 | Buy | $22.41 | 33,650 | 754,096 | 2,826,938 | Mar 26, 2018, 06:56 PM |
| ODT | Director | Mar 23, 2018 | Buy | $23.96 | 42,943 | 1,028,914 | 2,793,288 | Mar 26, 2018, 06:56 PM |
| ODT | Director | Mar 22, 2018 | Buy | $20.94 | 23,407 | 490,143 | 2,750,345 | Mar 26, 2018, 06:56 PM |
| ODT | Director | Dec 06, 2017 | Buy | $24.00 | 416,666 | 9,999,984 | 2,726,938 | Dec 08, 2017, 05:21 PM |
| MRTX | 10% Owner | Oct 03, 2017 | Option Exercise | $7.86 | 267,966 | 2,106,213 | 1,227,774 | Oct 03, 2017, 06:21 PM |
| MRTX | 10% Owner | Jan 06, 2017 | Buy | $5.60 | 286,163 | 1,602,513 | 1,037,994 | Jan 10, 2017, 05:00 PM |
| Symbol | Relationship | Date | Transaction | Value($) |
| ITOS | See remarks | Aug 23, 2023 | Sale | 5,692,673 |
| MRTX | See remarks | Aug 11, 2023 | Buy | 33,400,031 |
| MRTX | See remarks | Aug 11, 2023 | Buy | 1,599,417 |
| MRTX | See remarks | Aug 11, 2023 | Buy | 33,400,031 |
| MRTX | See remarks | Aug 11, 2023 | Buy | 1,599,417 |
| TNGX | See remarks | Aug 11, 2023 | Buy | 2,446,250 |
| RAIN | See remarks. | May 22, 2023 | Sale | 1,243,750 |
| TYRA | 10% Owner | Feb 10, 2023 | Sale | 878,611 |
| TYRA | 10% Owner | Feb 09, 2023 | Sale | 2,620,000 |
| RAIN | Director | Nov 04, 2022 | Buy | 5,667,996 |
| TNGX | 10% Owner | Oct 13, 2022 | Buy | 325,227 |
| TNGX | 10% Owner | Oct 12, 2022 | Buy | 221,640 |
| TNGX | 10% Owner | Oct 11, 2022 | Buy | 497,706 |
| ITOS | Director | May 09, 2022 | Sale | 5,265,842 |
| ITOS | Director | May 11, 2022 | Sale | 6,167,422 |
| ITOS | Director | May 10, 2022 | Sale | 2,515,970 |
| ITOS | Director | May 02, 2022 | Sale | 2,748,734 |
| ITOS | Director | Apr 29, 2022 | Sale | 3,388,821 |
| ITOS | Director | Apr 28, 2022 | Sale | 4,110,315 |
| ITOS | Director | Mar 23, 2022 | Buy | 656,980 |
| ITOS | Director | Mar 22, 2022 | Buy | 968,509 |
| ITOS | Director | Jan 03, 2022 | Sale | 24,677,378 |
| ITOS | Director | Jan 04, 2022 | Sale | 7,898,264 |
| ODT | Director | Nov 19, 2021 | Sale | 276,285 |
| ODT | Director | Nov 19, 2021 | Sale | 57,495 |
| ODT | Director | Nov 18, 2021 | Sale | 487,250 |
| ODT | Director | Nov 17, 2021 | Sale | 1,299,240 |
| ODT | Director | Nov 17, 2021 | Sale | 379,678 |
| TYRA | 10% Owner | Sep 17, 2021 | Buy | 10,000,000 |
| MRTX | 10% Owner | Mar 05, 2021 | Option Exercise | 611 |
| MRTX | 10% Owner | Mar 05, 2021 | Sale | 72,460,903 |
| ODT | Director | Dec 30, 2020 | Buy | 1,746,380 |
| ODT | Director | Dec 29, 2020 | Buy | 3,849,548 |
| ODT | Director | Dec 28, 2020 | Buy | 1,267,500 |
| MRTX | 10% Owner | Oct 30, 2020 | Option Exercise | 660 |
| MRTX | 10% Owner | Oct 30, 2020 | Option Exercise | 400 |
| MRTX | 10% Owner | Oct 30, 2020 | Sale | 80,800,000 |
| ODT | Director | Sep 29, 2020 | Buy | 1,717,760 |
| ODT | Director | Sep 28, 2020 | Buy | 1,214,396 |
| PMVP | Former 10% Owner | Sep 25, 2020 | Buy | 17,100,000 |
| ODT | Director | Sep 08, 2020 | Buy | 276,172 |
| ODT | Director | Sep 04, 2020 | Buy | 1,862,739 |
| ODT | Director | Sep 09, 2020 | Buy | 1,232,720 |
| ODT | Director | Aug 28, 2020 | Buy | 20,000,003 |
| ITOS | Director | Jul 28, 2020 | Buy | 27,075,000 |
| PAND | 10% Owner | Jul 21, 2020 | Buy | 12,999,996 |
| MRTX | Director | Jan 07, 2019 | Sale | 1,855,803 |
| MRTX | Director | Jan 08, 2019 | Sale | 528,000 |
| ODT | Director | Dec 26, 2018 | Buy | 311,815 |
| ODT | Director | Dec 21, 2018 | Buy | 1,347,015 |
| ODT | Director | Oct 24, 2018 | Buy | 394,753 |
| ODT | Director | Mar 26, 2018 | Buy | 754,096 |
| ODT | Director | Mar 23, 2018 | Buy | 1,028,914 |
| ODT | Director | Mar 22, 2018 | Buy | 490,143 |
| ODT | Director | Dec 06, 2017 | Buy | 9,999,984 |
| MRTX | 10% Owner | Oct 03, 2017 | Option Exercise | 2,106,213 |
| MRTX | 10% Owner | Jan 06, 2017 | Buy | 1,602,513 |