| Symbol | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| NKTX | Chief Executive Officer | Jun 20, 2023 | Sale | $4.85 | 1,704 | 8,264 | 313,402 | Jun 22, 2023, 04:20 PM |
| PCRX | Director | Jun 05, 2023 | Sale | $38.34 | 580 | 22,237 | 6,599 | Jun 07, 2023, 09:23 PM |
| PCRX | Director | May 15, 2023 | Option Exercise | $29.90 | 7,000 | 209,300 | 14,179 | May 17, 2023, 04:07 PM |
| PCRX | Director | May 15, 2023 | Sale | $41.85 | 7,000 | 292,950 | 7,179 | May 17, 2023, 04:07 PM |
| NKTX | Chief Executive Officer | Jan 17, 2023 | Sale | $5.49 | 3,691 | 20,264 | 313,106 | Jan 18, 2023, 07:04 PM |
| NKTX | Chief Executive Officer | Sep 29, 2022 | Sale | $13.00 | 498 | 6,474 | 250,461 | Sep 30, 2022, 04:30 PM |
| NKTX | Chief Executive Officer | Sep 28, 2022 | Sale | $13.03 | 23,376 | 304,615 | 250,959 | Sep 30, 2022, 04:30 PM |
| NKTX | Chief Executive Officer | Sep 21, 2022 | Sale | $13.01 | 6,126 | 79,717 | 274,335 | Sep 22, 2022, 05:32 PM |
| PCRX | Director | Jul 11, 2022 | Sale | $56.95 | 533 | 30,354 | 7,179 | Jul 13, 2022, 04:03 PM |
| NKTX | Chief Executive Officer | Sep 29, 2021 | Sale | $27.18 | 8,500 | 231,051 | 219,284 | Oct 01, 2021, 04:35 PM |
| NKTX | Chief Executive Officer | Jun 21, 2021 | Sale | $26.61 | 8,500 | 226,218 | 231,368 | Jun 23, 2021, 04:05 PM |
| PCRX | Director | Jun 04, 2021 | Sale | $62.19 | 630 | 39,180 | 5,486 | Jun 08, 2021, 04:13 PM |
| NKTX | Chief Executive Officer | Mar 30, 2021 | Sale | $30.74 | 17,000 | 522,540 | 241,600 | Apr 01, 2021, 06:15 AM |
| PCRX | Director | Mar 05, 2021 | Option Exercise | $13.98 | 3,000 | 41,940 | 9,116 | Mar 09, 2021, 04:12 PM |
| PCRX | Director | Mar 05, 2021 | Sale | $65.88 | 3,000 | 197,640 | 6,116 | Mar 09, 2021, 04:12 PM |
| PCRX | Director | Jun 04, 2020 | Sale | $47.46 | 2,025 | 96,106 | 4,856 | Jun 08, 2020, 09:05 PM |
| PCRX | Director | Jun 04, 2019 | Sale | $42.66 | 782 | 33,360 | 2,747 | Jun 06, 2019, 04:39 PM |
| PCRX | Director | Jun 04, 2018 | Sale | $33.90 | 771 | 26,137 | 2,747 | Jun 06, 2018, 08:07 PM |
| OMED | Chairman & CEO | Oct 10, 2017 | Sale | $4.24 | 1,398 | 5,931 | 77,534 | Oct 12, 2017, 06:35 PM |
| PCRX | Director | Aug 22, 2017 | Sale | $36.15 | 1,044 | 37,741 | 3,518 | Aug 24, 2017, 08:30 PM |
| OMED | Chairman & CEO | Apr 04, 2017 | Sale | $9.06 | 6,473 | 58,625 | 39,011 | Apr 05, 2017, 07:38 PM |
| OMED | Chairman & CEO | Jan 06, 2017 | Option Exercise | $1.43 | 21,369 | 30,558 | 58,692 | Jan 09, 2017, 05:55 PM |
| OMED | Chairman & CEO | Jan 05, 2017 | Option Exercise | $1.43 | 21,369 | 30,558 | 58,692 | Jan 09, 2017, 05:55 PM |
| OMED | Chairman & CEO | Jan 05, 2017 | Sale | $8.17 | 21,369 | 174,602 | 37,323 | Jan 09, 2017, 05:55 PM |
| OMED | Chairman & CEO | Jan 06, 2017 | Sale | $8.52 | 21,369 | 181,957 | 37,323 | Jan 09, 2017, 05:55 PM |
| RLYP | Director | Sep 01, 2016 | Option Exercise | $32.00 | 2,250 | 72,000 | 0 | Sep 02, 2016, 12:34 PM |
| RLYP | Director | Sep 01, 2016 | Option Exercise | $32.00 | 2,495 | 79,840 | 2,250 | Sep 02, 2016, 12:34 PM |
| PCRX | Director | Jun 06, 2016 | Sale | $46.95 | 1,136 | 53,335 | 1,717 | Jun 08, 2016, 07:02 PM |
| RLYP | Director | Jun 07, 2016 | Sale | $19.32 | 1,013 | 19,573 | 2,495 | Jun 08, 2016, 05:18 PM |
| PCRX | Director | Feb 17, 2016 | Option Exercise | $12.92 | 3,000 | 38,770 | 5,853 | Feb 22, 2016, 07:38 PM |
| PCRX | Director | Feb 17, 2016 | Sale | $60.00 | 3,000 | 180,000 | 2,853 | Feb 22, 2016, 07:38 PM |
| OMED | Chairman & CEO | Jan 06, 2016 | Sale | $22.28 | 2,412 | 53,731 | 22,102 | Jan 08, 2016, 07:25 PM |
| PCRX | Director | Nov 20, 2015 | Option Exercise | $10.81 | 3,000 | 32,430 | 5,853 | Nov 24, 2015, 06:32 PM |
| PCRX | Director | Nov 20, 2015 | Sale | $60.00 | 3,000 | 180,000 | 2,853 | Nov 24, 2015, 06:32 PM |
| PCRX | Director | Aug 17, 2015 | Option Exercise | $10.81 | 3,000 | 32,430 | 5,853 | Aug 19, 2015, 08:26 PM |
| PCRX | Director | Aug 17, 2015 | Sale | $60.02 | 3,000 | 180,060 | 2,853 | Aug 19, 2015, 08:26 PM |
| RLYP | Director | Jun 11, 2015 | Sale | $34.63 | 1,454 | 50,359 | 3,508 | Jun 15, 2015, 06:41 PM |
| PCRX | Director | Apr 10, 2015 | Option Exercise | $13.98 | 2,500 | 34,950 | 3,353 | Apr 14, 2015, 06:50 PM |
| PCRX | Director | Apr 10, 2015 | Sale | $88.00 | 2,500 | 220,000 | 853 | Apr 14, 2015, 06:50 PM |
| PCRX | Director | Jan 12, 2015 | Option Exercise | $13.98 | 2,500 | 34,950 | 3,353 | Jan 14, 2015, 04:12 PM |
| PCRX | Director | Jan 12, 2015 | Sale | $94.06 | 2,500 | 235,150 | 853 | Jan 14, 2015, 04:12 PM |
| OMED | Chairman & CEO | Oct 29, 2014 | Option Exercise | $1.43 | 8,385 | 11,991 | 31,616 | Oct 30, 2014, 07:27 PM |
| OMED | Chairman & CEO | Oct 28, 2014 | Option Exercise | $1.43 | 8,384 | 11,989 | 31,615 | Oct 30, 2014, 07:27 PM |
| OMED | Chairman & CEO | Oct 29, 2014 | Sale | $21.90 | 8,385 | 183,618 | 23,231 | Oct 30, 2014, 07:27 PM |
| OMED | Chairman & CEO | Oct 28, 2014 | Sale | $22.08 | 8,384 | 185,124 | 23,231 | Oct 30, 2014, 07:27 PM |
| PCRX | Director | Oct 10, 2014 | Option Exercise | $13.98 | 2,500 | 34,950 | 3,353 | Oct 14, 2014, 08:24 PM |
| PCRX | Director | Oct 10, 2014 | Sale | $94.87 | 2,500 | 237,175 | 853 | Oct 14, 2014, 08:24 PM |
| OMED | Chairman & CEO | Jul 29, 2014 | Option Exercise | $1.43 | 8,385 | 11,991 | 30,885 | Jul 30, 2014, 07:53 PM |
| OMED | Chairman & CEO | Jul 28, 2014 | Option Exercise | $1.43 | 8,385 | 11,991 | 30,885 | Jul 30, 2014, 07:53 PM |
| OMED | Chairman & CEO | Jul 29, 2014 | Sale | $22.28 | 8,385 | 186,802 | 22,500 | Jul 30, 2014, 07:53 PM |
| OMED | Chairman & CEO | Jul 28, 2014 | Sale | $21.94 | 8,385 | 183,936 | 22,600 | Jul 30, 2014, 07:53 PM |
| PCRX | Director | Jul 10, 2014 | Option Exercise | $13.98 | 2,500 | 34,950 | 3,353 | Jul 11, 2014, 08:26 PM |
| PCRX | Director | Jul 10, 2014 | Sale | $84.41 | 2,500 | 211,017 | 2,753 | Jul 11, 2014, 08:26 PM |
| PCRX | Director | May 15, 2013 | Buy | $29.30 | 853 | 24,993 | 853 | May 17, 2013, 06:02 PM |
| Symbol | Relationship | Date | Transaction | Value($) |
| NKTX | Chief Executive Officer | Jun 20, 2023 | Sale | 8,264 |
| PCRX | Director | Jun 05, 2023 | Sale | 22,237 |
| PCRX | Director | May 15, 2023 | Option Exercise | 209,300 |
| PCRX | Director | May 15, 2023 | Sale | 292,950 |
| NKTX | Chief Executive Officer | Jan 17, 2023 | Sale | 20,264 |
| NKTX | Chief Executive Officer | Sep 29, 2022 | Sale | 6,474 |
| NKTX | Chief Executive Officer | Sep 28, 2022 | Sale | 304,615 |
| NKTX | Chief Executive Officer | Sep 21, 2022 | Sale | 79,717 |
| PCRX | Director | Jul 11, 2022 | Sale | 30,354 |
| NKTX | Chief Executive Officer | Sep 29, 2021 | Sale | 231,051 |
| NKTX | Chief Executive Officer | Jun 21, 2021 | Sale | 226,218 |
| PCRX | Director | Jun 04, 2021 | Sale | 39,180 |
| NKTX | Chief Executive Officer | Mar 30, 2021 | Sale | 522,540 |
| PCRX | Director | Mar 05, 2021 | Option Exercise | 41,940 |
| PCRX | Director | Mar 05, 2021 | Sale | 197,640 |
| PCRX | Director | Jun 04, 2020 | Sale | 96,106 |
| PCRX | Director | Jun 04, 2019 | Sale | 33,360 |
| PCRX | Director | Jun 04, 2018 | Sale | 26,137 |
| OMED | Chairman & CEO | Oct 10, 2017 | Sale | 5,931 |
| PCRX | Director | Aug 22, 2017 | Sale | 37,741 |
| OMED | Chairman & CEO | Apr 04, 2017 | Sale | 58,625 |
| OMED | Chairman & CEO | Jan 06, 2017 | Option Exercise | 30,558 |
| OMED | Chairman & CEO | Jan 05, 2017 | Option Exercise | 30,558 |
| OMED | Chairman & CEO | Jan 05, 2017 | Sale | 174,602 |
| OMED | Chairman & CEO | Jan 06, 2017 | Sale | 181,957 |
| RLYP | Director | Sep 01, 2016 | Option Exercise | 72,000 |
| RLYP | Director | Sep 01, 2016 | Option Exercise | 79,840 |
| PCRX | Director | Jun 06, 2016 | Sale | 53,335 |
| RLYP | Director | Jun 07, 2016 | Sale | 19,573 |
| PCRX | Director | Feb 17, 2016 | Option Exercise | 38,770 |
| PCRX | Director | Feb 17, 2016 | Sale | 180,000 |
| OMED | Chairman & CEO | Jan 06, 2016 | Sale | 53,731 |
| PCRX | Director | Nov 20, 2015 | Option Exercise | 32,430 |
| PCRX | Director | Nov 20, 2015 | Sale | 180,000 |
| PCRX | Director | Aug 17, 2015 | Option Exercise | 32,430 |
| PCRX | Director | Aug 17, 2015 | Sale | 180,060 |
| RLYP | Director | Jun 11, 2015 | Sale | 50,359 |
| PCRX | Director | Apr 10, 2015 | Option Exercise | 34,950 |
| PCRX | Director | Apr 10, 2015 | Sale | 220,000 |
| PCRX | Director | Jan 12, 2015 | Option Exercise | 34,950 |
| PCRX | Director | Jan 12, 2015 | Sale | 235,150 |
| OMED | Chairman & CEO | Oct 29, 2014 | Option Exercise | 11,991 |
| OMED | Chairman & CEO | Oct 28, 2014 | Option Exercise | 11,989 |
| OMED | Chairman & CEO | Oct 29, 2014 | Sale | 183,618 |
| OMED | Chairman & CEO | Oct 28, 2014 | Sale | 185,124 |
| PCRX | Director | Oct 10, 2014 | Option Exercise | 34,950 |
| PCRX | Director | Oct 10, 2014 | Sale | 237,175 |
| OMED | Chairman & CEO | Jul 29, 2014 | Option Exercise | 11,991 |
| OMED | Chairman & CEO | Jul 28, 2014 | Option Exercise | 11,991 |
| OMED | Chairman & CEO | Jul 29, 2014 | Sale | 186,802 |
| OMED | Chairman & CEO | Jul 28, 2014 | Sale | 183,936 |
| PCRX | Director | Jul 10, 2014 | Option Exercise | 34,950 |
| PCRX | Director | Jul 10, 2014 | Sale | 211,017 |
| PCRX | Director | May 15, 2013 | Buy | 24,993 |