(GHDX)
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Market Cap: -
As of 12/31/69 07:00 PM EST. Market closed.
(GHDX)
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- (-)
Market Cap: -
As of 12/31/69 07:00 PM EST. Market closed.
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INSIDER TRANSACTIONS FOR
| Owner | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| Leber Laura | Chief Communication Officer | Oct 17, 2019 | Option Exercise | $22.98 | 13,183 | 302,945 | 26,919 | Oct 21, 2019, 07:31 PM |
| Leber Laura | Chief Communication Officer | Oct 17, 2019 | Sale | $70.94 | 13,183 | 935,228 | 13,736 | Oct 21, 2019, 07:31 PM |
| Vaughn James J | Chief Commercial Officer | Oct 08, 2019 | Option Exercise | $33.21 | 4,500 | 149,445 | 20,917 | Oct 09, 2019, 05:12 PM |
| Vaughn James J | Chief Commercial Officer | Oct 08, 2019 | Sale | $67.75 | 4,500 | 304,875 | 16,417 | Oct 09, 2019, 05:12 PM |
| Popovits Kimberly J | President and CEO | Oct 08, 2019 | Sale | $67.74 | 10,000 | 677,364 | 68,268 | Oct 09, 2019, 05:11 PM |
| Cole G Bradley | CFO | Oct 07, 2019 | Option Exercise | $30.84 | 22,560 | 695,750 | 61,530 | Oct 09, 2019, 05:10 PM |
| Cole G Bradley | CFO | Oct 07, 2019 | Sale | $69.01 | 22,560 | 1,556,886 | 38,970 | Oct 09, 2019, 05:10 PM |
| FUCHS HENRY J | Director | Oct 01, 2019 | Option Exercise | $67.28 | 185 | 12,447 | 7,833 | Oct 03, 2019, 08:05 PM |
| Flannelly Barry P | Director | Oct 01, 2019 | Option Exercise | $67.28 | 185 | 12,447 | 397 | Oct 03, 2019, 08:01 PM |
| Cohen Fred E | Director | Oct 01, 2019 | Option Exercise | $67.28 | 185 | 12,447 | 69,120 | Oct 03, 2019, 08:00 PM |
| GRAHAM GINGER L | Director | Oct 01, 2019 | Option Exercise | $67.28 | 185 | 12,447 | 53,304 | Oct 03, 2019, 07:59 PM |
| BAKER BROS. ADVISORS LP | Director | Oct 01, 2019 | Option Exercise | $67.28 | 1,850 | 124,468 | 7,642,042 | Oct 03, 2019, 06:08 PM |
| Shak Steven | Chief Scientific Officer | Sep 17, 2019 | Sale | $71.47 | 25,000 | 1,786,692 | 58,795 | Sep 19, 2019, 04:58 PM |
| Popovits Kimberly J | President and CEO | Sep 09, 2019 | Sale | $72.53 | 10,000 | 725,285 | 81,351 | Sep 11, 2019, 04:16 PM |
| Cole G Bradley | CFO | Sep 10, 2019 | Option Exercise | $28.05 | 18,112 | 508,042 | 57,082 | Sep 11, 2019, 04:16 PM |
| Cole G Bradley | CFO | Sep 09, 2019 | Option Exercise | $28.05 | 25,000 | 701,250 | 63,970 | Sep 11, 2019, 04:16 PM |
| Cole G Bradley | CFO | Sep 09, 2019 | Sale | $72.52 | 25,000 | 1,813,071 | 46,439 | Sep 11, 2019, 04:16 PM |
| Cole G Bradley | CFO | Sep 10, 2019 | Sale | $71.79 | 18,112 | 1,300,277 | 43,779 | Sep 11, 2019, 04:16 PM |
| Vaughn James J | Chief Commercial Officer | Sep 09, 2019 | Option Exercise | $31.82 | 4,500 | 143,175 | 20,917 | Sep 11, 2019, 04:15 PM |
| Vaughn James J | Chief Commercial Officer | Sep 09, 2019 | Sale | $72.50 | 4,500 | 326,269 | 17,917 | Sep 11, 2019, 04:15 PM |
| Pla Frederic | COO | Aug 19, 2019 | Option Exercise | $27.48 | 1,251 | 34,377 | 33,142 | Aug 21, 2019, 07:40 PM |
| Pla Frederic | COO | Aug 19, 2019 | Sale | $75.00 | 1,251 | 93,825 | 31,891 | Aug 21, 2019, 07:40 PM |
| Radford Jason W. | Chief Legal Officer | Aug 15, 2019 | Sale | $74.13 | 2,181 | 161,669 | 29,395 | Aug 19, 2019, 07:57 PM |
| Radford Jason W. | Chief Legal Officer | Feb 19, 2019 | Sale | $83.16 | 3,508 | 291,709 | 31,787 | Aug 19, 2019, 07:55 PM |
| Cole G Bradley | CFO | Aug 12, 2019 | Option Exercise | $29.34 | 60,000 | 1,760,400 | 98,970 | Aug 14, 2019, 04:22 PM |
| Cole G Bradley | CFO | Aug 12, 2019 | Sale | $73.31 | 60,000 | 4,398,588 | 40,195 | Aug 14, 2019, 04:22 PM |
| Popovits Kimberly J | President and CEO | Aug 12, 2019 | Option Exercise | $29.34 | 25,000 | 733,500 | 133,468 | Aug 14, 2019, 04:21 PM |
| Popovits Kimberly J | President and CEO | Aug 13, 2019 | Option Exercise | $29.34 | 15,000 | 440,100 | 123,468 | Aug 14, 2019, 04:21 PM |
| Popovits Kimberly J | President and CEO | Aug 13, 2019 | Sale | $74.21 | 25,000 | 1,855,199 | 116,075 | Aug 14, 2019, 04:21 PM |
| Popovits Kimberly J | President and CEO | Aug 12, 2019 | Sale | $73.31 | 25,000 | 1,832,653 | 108,915 | Aug 14, 2019, 04:21 PM |
| Popovits Kimberly J | President and CEO | Aug 09, 2019 | Option Exercise | $29.34 | 25,000 | 733,500 | 133,468 | Aug 12, 2019, 07:08 PM |
| Popovits Kimberly J | President and CEO | Aug 08, 2019 | Option Exercise | $29.34 | 25,000 | 733,500 | 133,468 | Aug 12, 2019, 07:08 PM |
| Popovits Kimberly J | President and CEO | Aug 09, 2019 | Sale | $73.66 | 25,000 | 1,841,542 | 109,468 | Aug 12, 2019, 07:08 PM |
| Popovits Kimberly J | President and CEO | Aug 08, 2019 | Sale | $73.85 | 25,000 | 1,846,266 | 117,703 | Aug 12, 2019, 07:08 PM |
| Vaughn James J | Chief Commercial Officer | Aug 08, 2019 | Option Exercise | $31.63 | 4,500 | 142,345 | 20,917 | Aug 12, 2019, 07:08 PM |
| Vaughn James J | Chief Commercial Officer | Aug 08, 2019 | Sale | $73.74 | 4,500 | 331,825 | 20,520 | Aug 12, 2019, 07:08 PM |
| McEachron Kim | Chief People Officer | Aug 05, 2019 | Option Exercise | $30.16 | 12,103 | 365,005 | 48,575 | Aug 07, 2019, 04:54 PM |
| McEachron Kim | Chief People Officer | Aug 05, 2019 | Sale | $71.53 | 12,103 | 865,723 | 36,472 | Aug 07, 2019, 04:54 PM |
| Shak Steven | Chief Scientific Officer | Aug 06, 2019 | Sale | $72.37 | 25,000 | 1,809,331 | 91,935 | Aug 07, 2019, 04:53 PM |
| Shak Steven | Chief Scientific Officer | Aug 05, 2019 | Sale | $71.29 | 25,000 | 1,782,129 | 111,266 | Aug 07, 2019, 04:53 PM |
| Shak Steven | Chief Scientific Officer | Aug 02, 2019 | Sale | $72.43 | 25,000 | 1,810,858 | 133,795 | Aug 05, 2019, 04:35 PM |
| Shak Steven | Chief Scientific Officer | Aug 01, 2019 | Sale | $72.87 | 25,000 | 1,821,784 | 166,167 | Aug 05, 2019, 04:35 PM |
| Cole G Bradley | CFO | Jul 09, 2019 | Option Exercise | $17.18 | 6,471 | 111,172 | 50,441 | Jul 11, 2019, 06:13 PM |
| Cole G Bradley | CFO | Jul 09, 2019 | Sale | $57.08 | 6,471 | 369,386 | 49,003 | Jul 11, 2019, 06:13 PM |
| Shak Steven | Chief Scientific Officer | Jul 09, 2019 | Sale | $56.52 | 25,000 | 1,412,943 | 191,595 | Jul 10, 2019, 07:23 PM |
| Shak Steven | Chief Scientific Officer | Jul 08, 2019 | Sale | $57.10 | 25,000 | 1,427,384 | 212,843 | Jul 10, 2019, 07:23 PM |
| Vaughn James J | Chief Commercial Officer | Jul 08, 2019 | Option Exercise | $31.12 | 4,500 | 140,040 | 20,917 | Jul 09, 2019, 04:15 PM |
| Vaughn James J | Chief Commercial Officer | Jul 08, 2019 | Sale | $57.09 | 4,500 | 256,886 | 18,418 | Jul 09, 2019, 04:15 PM |
| McEachron Kim | Chief People Officer | Jul 05, 2019 | Option Exercise | $30.69 | 5,335 | 163,731 | 41,807 | Jul 09, 2019, 04:13 PM |
| McEachron Kim | Chief People Officer | Jul 05, 2019 | Sale | $60.01 | 5,335 | 320,151 | 36,472 | Jul 09, 2019, 04:13 PM |
| Cohen Fred E | Director | Jul 01, 2019 | Option Exercise | $58.86 | 212 | 12,478 | 68,935 | Jul 03, 2019, 05:50 PM |
| Flannelly Barry P | Director | Jul 01, 2019 | Option Exercise | $58.86 | 212 | 12,478 | 212 | Jul 03, 2019, 05:50 PM |
| FUCHS HENRY J | Director | Jul 01, 2019 | Option Exercise | $58.86 | 212 | 12,478 | 7,648 | Jul 03, 2019, 05:49 PM |
| GRAHAM GINGER L | Director | Jul 01, 2019 | Option Exercise | $58.86 | 212 | 12,478 | 53,119 | Jul 03, 2019, 05:48 PM |
| BAKER BROS. ADVISORS LP | Director | Jul 01, 2019 | Option Exercise | $58.86 | 2,544 | 149,740 | 7,641,672 | Jul 03, 2019, 01:16 PM |
| Shak Steven | Chief Scientific Officer | Jun 14, 2019 | Option Exercise | $31.12 | 10,550 | 328,316 | 244,345 | Jun 17, 2019, 06:26 PM |
| Shak Steven | Chief Scientific Officer | Jun 13, 2019 | Option Exercise | $31.12 | 25,000 | 778,000 | 258,795 | Jun 17, 2019, 06:26 PM |
| Shak Steven | Chief Scientific Officer | Jun 14, 2019 | Sale | $51.66 | 10,550 | 545,003 | 235,459 | Jun 17, 2019, 06:26 PM |
| Shak Steven | Chief Scientific Officer | Jun 13, 2019 | Sale | $51.94 | 25,000 | 1,298,572 | 234,604 | Jun 17, 2019, 06:26 PM |
| Shak Steven | Chief Scientific Officer | Jun 12, 2019 | Option Exercise | $30.95 | 25,000 | 773,768 | 258,479 | Jun 13, 2019, 07:33 PM |
| Shak Steven | Chief Scientific Officer | Jun 11, 2019 | Option Exercise | $30.89 | 25,000 | 772,278 | 258,479 | Jun 13, 2019, 07:33 PM |
| Shak Steven | Chief Scientific Officer | Jun 11, 2019 | Sale | $51.43 | 25,000 | 1,285,702 | 237,181 | Jun 13, 2019, 07:33 PM |
| Shak Steven | Chief Scientific Officer | Jun 12, 2019 | Sale | $51.34 | 25,000 | 1,283,477 | 233,479 | Jun 13, 2019, 07:33 PM |
| Cole G Bradley | CFO | Jun 11, 2019 | Option Exercise | $17.18 | 5,000 | 85,900 | 48,722 | Jun 13, 2019, 07:31 PM |
| Cole G Bradley | CFO | Jun 11, 2019 | Sale | $51.46 | 5,000 | 257,281 | 44,492 | Jun 13, 2019, 07:31 PM |
| Vaughn James J | Chief Commercial Officer | Jun 06, 2019 | Option Exercise | $31.12 | 4,500 | 140,040 | 24,920 | Jun 10, 2019, 07:37 PM |
| Vaughn James J | Chief Commercial Officer | Jun 06, 2019 | Sale | $52.47 | 8,745 | 458,829 | 22,320 | Jun 10, 2019, 07:37 PM |
| Cole G Bradley | CFO | May 14, 2019 | Option Exercise | $20.44 | 11,424 | 233,524 | 50,146 | May 15, 2019, 04:55 PM |
| Cole G Bradley | CFO | May 14, 2019 | Sale | $57.17 | 11,424 | 653,152 | 48,396 | May 15, 2019, 04:55 PM |
| Vaughn James J | Chief Commercial Officer | May 08, 2019 | Option Exercise | $31.12 | 4,500 | 140,040 | 27,664 | May 10, 2019, 08:10 PM |
| Vaughn James J | Chief Commercial Officer | May 08, 2019 | Sale | $58.08 | 7,244 | 420,730 | 27,064 | May 10, 2019, 08:10 PM |
| Shak Steven | Chief Scientific Officer | May 08, 2019 | Sale | $57.90 | 25,000 | 1,447,616 | 255,379 | May 10, 2019, 08:07 PM |
| BAKER BROS. ADVISORS LP | Director | Apr 12, 2019 | Sale | $65.32 | 11,204 | 731,889 | 7,639,338 | Apr 12, 2019, 05:02 PM |
| BAKER BROS. ADVISORS LP | Director | Apr 12, 2019 | Sale | $65.30 | 287,465 | 18,770,152 | 7,712,345 | Apr 12, 2019, 05:01 PM |
| BAKER BROS. ADVISORS LP | Director | Apr 11, 2019 | Sale | $66.90 | 202,281 | 13,533,252 | 7,991,484 | Apr 12, 2019, 05:01 PM |
| Cole G Bradley | CFO | Apr 09, 2019 | Option Exercise | $21.05 | 15,000 | 315,700 | 58,722 | Apr 11, 2019, 06:11 PM |
| Cole G Bradley | CFO | Apr 09, 2019 | Sale | $67.61 | 15,000 | 1,014,120 | 53,826 | Apr 11, 2019, 06:11 PM |
| Vaughn James J | Chief Commercial Officer | Apr 08, 2019 | Option Exercise | $31.12 | 3,000 | 93,360 | 26,164 | Apr 10, 2019, 07:48 PM |
| Vaughn James J | Chief Commercial Officer | Apr 08, 2019 | Sale | $67.73 | 3,000 | 203,179 | 25,202 | Apr 10, 2019, 07:48 PM |
| Popovits Kimberly J | President and CEO | Apr 08, 2019 | Sale | $66.93 | 10,000 | 669,321 | 111,416 | Apr 10, 2019, 07:45 PM |
| BAKER BROS. ADVISORS LP | Director | Apr 10, 2019 | Sale | $69.12 | 13,146 | 908,684 | 8,052,102 | Apr 10, 2019, 05:24 PM |
| BAKER BROS. ADVISORS LP | Director | Apr 10, 2019 | Sale | $68.70 | 124,542 | 8,556,110 | 8,062,934 | Apr 10, 2019, 05:24 PM |
| BAKER BROS. ADVISORS LP | Director | Apr 09, 2019 | Sale | $67.70 | 21,063 | 1,425,885 | 8,181,095 | Apr 10, 2019, 05:24 PM |
| BAKER BROS. ADVISORS LP | Director | Apr 08, 2019 | Sale | $67.90 | 22,648 | 1,537,720 | 8,182,908 | Apr 10, 2019, 05:24 PM |
| BAKER BROS. ADVISORS LP | Director | Apr 03, 2019 | Sale | $68.90 | 97,269 | 6,701,718 | 8,332,332 | Apr 05, 2019, 05:51 PM |
| BAKER BROS. ADVISORS LP | Director | Apr 05, 2019 | Sale | $68.69 | 77,648 | 5,333,397 | 8,244,432 | Apr 05, 2019, 05:51 PM |
| BAKER BROS. ADVISORS LP | Director | Apr 04, 2019 | Sale | $66.64 | 81,053 | 5,401,340 | 8,265,548 | Apr 05, 2019, 05:51 PM |
| FUCHS HENRY J | Director | Apr 01, 2019 | Option Exercise | $66.84 | 149 | 9,959 | 6,481 | Apr 03, 2019, 06:01 PM |
| Cohen Fred E | Director | Apr 01, 2019 | Option Exercise | $66.84 | 149 | 9,959 | 67,768 | Apr 03, 2019, 06:00 PM |
| GRAHAM GINGER L | Director | Apr 01, 2019 | Option Exercise | $66.84 | 149 | 9,959 | 51,952 | Apr 03, 2019, 06:00 PM |
| BAKER BROS. ADVISORS LP | Director | Apr 01, 2019 | Option Exercise | $66.84 | 1,788 | 119,510 | 8,412,478 | Apr 03, 2019, 05:35 PM |
| Shak Steven | Chief Scientific Officer | Mar 29, 2019 | Sale | $69.38 | 25,000 | 1,734,470 | 294,107 | Apr 01, 2019, 06:58 PM |
| Shak Steven | Chief Scientific Officer | Mar 28, 2019 | Sale | $68.53 | 25,000 | 1,713,259 | 318,859 | Apr 01, 2019, 06:58 PM |
| Shak Steven | Chief Scientific Officer | Apr 01, 2019 | Sale | $67.76 | 25,000 | 1,694,059 | 272,958 | Apr 01, 2019, 06:58 PM |
| BAKER BROS. ADVISORS LP | Director | Mar 21, 2019 | Sale | $74.71 | 56,651 | 4,232,164 | 8,412,180 | Mar 25, 2019, 05:05 PM |
| Pla Frederic | COO | Mar 18, 2019 | Option Exercise | $27.48 | 1,000 | 27,480 | 32,575 | Mar 19, 2019, 06:42 PM |
| Pla Frederic | COO | Mar 19, 2019 | Option Exercise | $28.77 | 4,700 | 135,234 | 36,275 | Mar 19, 2019, 06:42 PM |
| Pla Frederic | COO | Mar 19, 2019 | Sale | $75.00 | 4,700 | 352,500 | 31,575 | Mar 19, 2019, 06:42 PM |
| Pla Frederic | COO | Mar 18, 2019 | Sale | $75.12 | 1,000 | 75,122 | 31,575 | Mar 19, 2019, 06:42 PM |
| BAKER BROS. ADVISORS LP | Director | Mar 19, 2019 | Sale | $74.34 | 50,100 | 3,724,594 | 8,458,858 | Mar 19, 2019, 05:48 PM |
| BAKER BROS. ADVISORS LP | Director | Mar 19, 2019 | Sale | $74.34 | 50,100 | 3,724,594 | 8,458,858 | Mar 19, 2019, 05:37 PM |
| BAKER BROS. ADVISORS LP | Director | Mar 19, 2019 | Sale | $74.63 | 105,126 | 7,845,648 | 8,500,139 | Mar 19, 2019, 05:31 PM |
| BAKER BROS. ADVISORS LP | Director | Mar 18, 2019 | Sale | $74.19 | 109,533 | 8,125,969 | 8,586,759 | Mar 19, 2019, 05:31 PM |
| BAKER BROS. ADVISORS LP | Director | Mar 15, 2019 | Sale | $74.64 | 55,347 | 4,131,088 | 8,719,547 | Mar 19, 2019, 05:31 PM |
| BAKER BROS. ADVISORS LP | Director | Mar 14, 2019 | Sale | $76.49 | 65,094 | 4,978,787 | 8,724,263 | Mar 14, 2019, 05:03 PM |
| BAKER BROS. ADVISORS LP | Director | Mar 13, 2019 | Sale | $75.92 | 80,253 | 6,092,923 | 8,839,544 | Mar 14, 2019, 05:03 PM |
| BAKER BROS. ADVISORS LP | Director | Mar 12, 2019 | Sale | $75.63 | 74,180 | 5,610,248 | 8,842,376 | Mar 14, 2019, 05:03 PM |
| Cole G Bradley | CFO | Mar 12, 2019 | Option Exercise | $21.05 | 15,000 | 315,700 | 58,722 | Mar 14, 2019, 04:06 PM |
| Cole G Bradley | CFO | Mar 12, 2019 | Sale | $75.15 | 15,000 | 1,127,273 | 54,722 | Mar 14, 2019, 04:06 PM |
| Popovits Kimberly J | President and CEO | Mar 08, 2019 | Sale | $73.22 | 10,000 | 732,237 | 126,799 | Mar 12, 2019, 09:47 PM |
| Vaughn James J | Chief Commercial Officer | Mar 07, 2019 | Option Exercise | $31.12 | 3,000 | 93,360 | 25,790 | Mar 11, 2019, 06:42 PM |
| Vaughn James J | Chief Commercial Officer | Mar 07, 2019 | Sale | $73.87 | 3,000 | 221,596 | 25,190 | Mar 11, 2019, 06:42 PM |
| BAKER BROS. ADVISORS LP | Director | Mar 11, 2019 | Sale | $75.00 | 49,035 | 3,677,484 | 8,906,794 | Mar 11, 2019, 04:59 PM |
| BAKER BROS. ADVISORS LP | Director | Mar 08, 2019 | Sale | $73.55 | 22,700 | 1,669,519 | 8,943,901 | Mar 11, 2019, 04:59 PM |
| BAKER BROS. ADVISORS LP | Director | Mar 07, 2019 | Sale | $73.72 | 2,000 | 147,445 | 8,962,604 | Mar 11, 2019, 04:59 PM |
| BAKER BROS. ADVISORS LP | Director | Mar 05, 2019 | Sale | $77.04 | 10,300 | 793,504 | 8,964,251 | Mar 05, 2019, 06:30 PM |
| BAKER BROS. ADVISORS LP | Director | Mar 04, 2019 | Sale | $76.49 | 27,811 | 2,127,250 | 8,972,737 | Mar 05, 2019, 06:30 PM |
| BAKER BROS. ADVISORS LP | Director | Mar 01, 2019 | Sale | $77.20 | 79,276 | 6,120,387 | 9,054,063 | Mar 05, 2019, 06:30 PM |
| Shak Steven | Chief Scientific Officer | Mar 01, 2019 | Option Exercise | $28.05 | 25,000 | 701,250 | 360,479 | Mar 05, 2019, 12:00 AM |
| Shak Steven | Chief Scientific Officer | Mar 04, 2019 | Option Exercise | $28.05 | 7,500 | 210,375 | 342,979 | Mar 05, 2019, 12:00 AM |
| Shak Steven | Chief Scientific Officer | Mar 04, 2019 | Sale | $75.89 | 7,500 | 569,202 | 341,061 | Mar 05, 2019, 12:00 AM |
| Shak Steven | Chief Scientific Officer | Mar 01, 2019 | Sale | $77.22 | 25,000 | 1,930,424 | 342,901 | Mar 05, 2019, 12:00 AM |
| Shak Steven | Chief Scientific Officer | Feb 27, 2019 | Option Exercise | $17.18 | 25,000 | 429,500 | 360,479 | Mar 01, 2019, 07:05 PM |
| Shak Steven | Chief Scientific Officer | Feb 28, 2019 | Option Exercise | $19.35 | 25,000 | 483,850 | 360,479 | Mar 01, 2019, 07:05 PM |
| Shak Steven | Chief Scientific Officer | Feb 28, 2019 | Sale | $76.40 | 25,000 | 1,909,972 | 355,177 | Mar 01, 2019, 07:05 PM |
| Shak Steven | Chief Scientific Officer | Feb 27, 2019 | Sale | $76.59 | 25,000 | 1,914,824 | 337,672 | Mar 01, 2019, 07:05 PM |
| BAKER BROS. ADVISORS LP | Director | Feb 28, 2019 | Sale | $76.20 | 600 | 45,719 | 9,060,972 | Feb 28, 2019, 06:22 PM |
| BAKER BROS. ADVISORS LP | Director | Feb 26, 2019 | Option Exercise | $17.59 | 16,500 | 290,235 | 9,100,815 | Feb 28, 2019, 06:21 PM |
| BAKER BROS. ADVISORS LP | Director | Feb 27, 2019 | Sale | $76.65 | 39,109 | 2,997,792 | 9,062,207 | Feb 28, 2019, 06:21 PM |
| BAKER BROS. ADVISORS LP | Director | Feb 26, 2019 | Sale | $78.11 | 8,650 | 675,614 | 9,094,309 | Feb 28, 2019, 06:21 PM |
| FUCHS HENRY J | Director | Feb 25, 2019 | Option Exercise | $27.75 | 3,521 | 97,708 | 9,853 | Feb 26, 2019, 04:51 PM |
| FUCHS HENRY J | Director | Feb 22, 2019 | Option Exercise | $32.22 | 26,479 | 853,192 | 32,811 | Feb 26, 2019, 04:51 PM |
| FUCHS HENRY J | Director | Feb 22, 2019 | Sale | $81.89 | 26,479 | 2,168,403 | 21,332 | Feb 26, 2019, 04:51 PM |
| FUCHS HENRY J | Director | Feb 25, 2019 | Sale | $79.02 | 3,521 | 278,226 | 6,853 | Feb 26, 2019, 04:51 PM |
| Cohen Fred E | Director | Feb 22, 2019 | Option Exercise | $26.01 | 10,000 | 260,100 | 77,619 | Feb 26, 2019, 04:49 PM |
| Cohen Fred E | Director | Feb 22, 2019 | Sale | $78.86 | 10,000 | 788,559 | 68,312 | Feb 26, 2019, 04:49 PM |
| Pla Frederic | COO | Feb 21, 2019 | Sale | $86.51 | 783 | 67,736 | 31,575 | Feb 25, 2019, 08:19 PM |
| Vaughn James J | Chief Commercial Officer | Feb 15, 2019 | Option Exercise | $83.34 | 2,904 | 242,019 | 21,595 | Feb 25, 2019, 08:15 PM |
| Shak Steven | Chief Scientific Officer | Feb 15, 2019 | Option Exercise | $83.34 | 3,492 | 291,023 | 335,479 | Feb 25, 2019, 08:15 PM |
| Radford Jason W. | Chief Legal Officer | Feb 15, 2019 | Option Exercise | $83.34 | 3,720 | 310,025 | 34,676 | Feb 25, 2019, 08:13 PM |
| Popovits Kimberly J | President and CEO | Feb 15, 2019 | Option Exercise | $83.34 | 12,890 | 1,074,253 | 55,138 | Feb 25, 2019, 08:12 PM |
| Pla Frederic | COO | Feb 15, 2019 | Option Exercise | $83.34 | 3,320 | 276,689 | 36,358 | Feb 25, 2019, 08:03 PM |
| McEachron Kim | Chief People Officer | Feb 15, 2019 | Option Exercise | $83.34 | 2,489 | 207,433 | 36,077 | Feb 25, 2019, 07:58 PM |
| Leber Laura | Chief Communication Officer | Feb 15, 2019 | Option Exercise | $83.34 | 2,106 | 175,514 | 17,512 | Feb 25, 2019, 07:57 PM |
| Cole G Bradley | CFO | Feb 15, 2019 | Option Exercise | $83.34 | 4,345 | 362,112 | 43,722 | Feb 25, 2019, 07:56 PM |
| Leber Laura | Chief Communication Officer | Feb 21, 2019 | Option Exercise | $22.98 | 1,817 | 41,755 | 22,666 | Feb 22, 2019, 08:45 PM |
| Leber Laura | Chief Communication Officer | Feb 20, 2019 | Option Exercise | $17.18 | 18,750 | 322,125 | 39,599 | Feb 22, 2019, 08:45 PM |
| Leber Laura | Chief Communication Officer | Feb 21, 2019 | Sale | $80.24 | 5,634 | 452,076 | 21,599 | Feb 22, 2019, 08:45 PM |
| Leber Laura | Chief Communication Officer | Feb 20, 2019 | Sale | $82.87 | 18,750 | 1,553,824 | 24,120 | Feb 22, 2019, 08:45 PM |
| Radford Jason W. | Chief Legal Officer | Feb 19, 2019 | Sale | $83.16 | 3,508 | 291,709 | 35,507 | Feb 21, 2019, 07:25 PM |
| Vaughn James J | Chief Commercial Officer | Feb 19, 2019 | Option Exercise | $30.23 | 1,195 | 36,130 | 25,320 | Feb 21, 2019, 07:24 PM |
| Pla Frederic | COO | Feb 19, 2019 | Option Exercise | $28.55 | 5,700 | 162,714 | 45,378 | Feb 21, 2019, 07:24 PM |
| Pla Frederic | COO | Feb 19, 2019 | Sale | $83.16 | 9,700 | 806,661 | 39,294 | Feb 21, 2019, 07:24 PM |
| Popovits Kimberly J | President and CEO | Feb 14, 2019 | Option Exercise | $17.18 | 47,900 | 822,922 | 164,882 | Feb 19, 2019, 07:38 PM |
| Popovits Kimberly J | President and CEO | Feb 14, 2019 | Sale | $81.70 | 47,900 | 3,913,615 | 130,882 | Feb 19, 2019, 07:38 PM |
| Cole G Bradley | CFO | Feb 12, 2019 | Option Exercise | $21.05 | 15,000 | 315,700 | 58,067 | Feb 14, 2019, 05:50 PM |
| Cole G Bradley | CFO | Feb 12, 2019 | Sale | $80.87 | 15,000 | 1,213,024 | 52,132 | Feb 14, 2019, 05:50 PM |
| Vaughn James J | Chief Commercial Officer | Feb 07, 2019 | Option Exercise | $31.12 | 3,000 | 93,360 | 27,125 | Feb 11, 2019, 07:53 PM |
| Vaughn James J | Chief Commercial Officer | Feb 07, 2019 | Sale | $77.42 | 3,000 | 232,272 | 25,075 | Feb 11, 2019, 07:53 PM |
| Shak Steven | Chief Scientific Officer | Feb 04, 2019 | Option Exercise | $20.66 | 25,000 | 516,500 | 364,671 | Feb 05, 2019, 05:55 PM |
| Shak Steven | Chief Scientific Officer | Feb 01, 2019 | Option Exercise | $22.98 | 25,000 | 574,500 | 364,671 | Feb 05, 2019, 05:55 PM |
| Shak Steven | Chief Scientific Officer | Feb 04, 2019 | Sale | $76.73 | 25,000 | 1,918,308 | 362,479 | Feb 05, 2019, 05:55 PM |
| Shak Steven | Chief Scientific Officer | Feb 01, 2019 | Sale | $75.86 | 25,000 | 1,896,384 | 359,331 | Feb 05, 2019, 05:55 PM |
| Shak Steven | Chief Scientific Officer | Jan 31, 2019 | Option Exercise | $29.34 | 25,000 | 733,500 | 364,671 | Feb 01, 2019, 07:08 PM |
| Shak Steven | Chief Scientific Officer | Jan 30, 2019 | Option Exercise | $29.34 | 25,000 | 733,500 | 364,671 | Feb 01, 2019, 07:08 PM |
| Shak Steven | Chief Scientific Officer | Jan 31, 2019 | Sale | $74.98 | 25,000 | 1,874,571 | 362,863 | Feb 01, 2019, 07:08 PM |
| Shak Steven | Chief Scientific Officer | Jan 30, 2019 | Sale | $73.49 | 25,000 | 1,837,229 | 361,570 | Feb 01, 2019, 07:08 PM |
| BAKER BROS. ADVISORS LP | Director | Jan 28, 2019 | Sale | $71.07 | 46,477 | 3,302,980 | 9,106,199 | Jan 30, 2019, 04:00 PM |
| BAKER BROS. ADVISORS LP | Director | Jan 23, 2019 | Sale | $70.67 | 37,512 | 2,651,092 | 9,273,669 | Jan 25, 2019, 05:19 PM |
| BAKER BROS. ADVISORS LP | Director | Jan 25, 2019 | Sale | $72.20 | 91,916 | 6,636,648 | 9,130,859 | Jan 25, 2019, 05:19 PM |
| BAKER BROS. ADVISORS LP | Director | Jan 24, 2019 | Sale | $72.02 | 79,403 | 5,718,588 | 9,206,595 | Jan 25, 2019, 05:19 PM |
| Radford Jason W. | Chief Legal Officer | Jan 22, 2019 | Sale | $71.44 | 2,963 | 211,683 | 32,751 | Jan 24, 2019, 06:30 PM |
| Vaughn James J | Chief Commercial Officer | Jan 17, 2019 | Option Exercise | $28.74 | 2,222 | 63,854 | 19,985 | Jan 22, 2019, 07:33 PM |
| BAKER BROS. ADVISORS LP | Director | Jan 22, 2019 | Sale | $71.00 | 51,606 | 3,664,031 | 9,302,929 | Jan 22, 2019, 05:27 PM |
| BAKER BROS. ADVISORS LP | Director | Jan 17, 2019 | Sale | $70.79 | 181,747 | 12,866,124 | 9,501,955 | Jan 22, 2019, 05:26 PM |
| BAKER BROS. ADVISORS LP | Director | Jan 22, 2019 | Sale | $71.61 | 12,800 | 916,641 | 9,345,450 | Jan 22, 2019, 05:26 PM |
| BAKER BROS. ADVISORS LP | Director | Jan 18, 2019 | Sale | $72.73 | 177,142 | 12,884,344 | 9,369,592 | Jan 22, 2019, 05:26 PM |
| BAKER BROS. ADVISORS LP | Director | Jan 14, 2019 | Sale | $70.07 | 600 | 42,043 | 9,651,709 | Jan 14, 2019, 05:11 PM |
| BAKER BROS. ADVISORS LP | Director | Jan 11, 2019 | Sale | $70.22 | 28,474 | 1,999,533 | 9,652,202 | Jan 14, 2019, 05:11 PM |
| BAKER BROS. ADVISORS LP | Director | Jan 10, 2019 | Sale | $70.28 | 10,185 | 715,780 | 9,675,664 | Jan 14, 2019, 05:11 PM |
| Cole G Bradley | CFO | Jan 08, 2019 | Option Exercise | $21.05 | 15,000 | 315,700 | 54,047 | Jan 09, 2019, 07:43 PM |
| Cole G Bradley | CFO | Jan 08, 2019 | Sale | $67.03 | 15,000 | 1,005,401 | 51,947 | Jan 09, 2019, 07:43 PM |
| Vaughn James J | Chief Commercial Officer | Jan 08, 2019 | Option Exercise | $31.12 | 3,000 | 93,360 | 20,763 | Jan 09, 2019, 07:42 PM |
| Vaughn James J | Chief Commercial Officer | Jan 08, 2019 | Sale | $67.06 | 3,000 | 201,181 | 19,963 | Jan 09, 2019, 07:42 PM |
| Cohen Fred E | Director | Jan 01, 2019 | Option Exercise | $64.41 | 155 | 9,984 | 67,619 | Jan 03, 2019, 07:13 PM |
| FUCHS HENRY J | Director | Jan 01, 2019 | Option Exercise | $64.41 | 155 | 9,984 | 6,332 | Jan 03, 2019, 07:13 PM |
| GRAHAM GINGER L | Director | Jan 01, 2019 | Option Exercise | $64.41 | 155 | 9,984 | 51,803 | Jan 03, 2019, 07:12 PM |
| BAKER BROS. ADVISORS LP | Director | Jan 01, 2019 | Option Exercise | $64.41 | 1,860 | 119,803 | 9,684,056 | Jan 03, 2019, 12:00 AM |
| Popovits Kimberly J | President and CEO | Dec 18, 2018 | Sale | $66.69 | 25,000 | 1,667,285 | 137,912 | Dec 19, 2018, 05:59 PM |
| Popovits Kimberly J | President and CEO | Dec 17, 2018 | Sale | $66.89 | 25,000 | 1,672,242 | 159,275 | Dec 19, 2018, 05:59 PM |
| GRAHAM GINGER L | Director | Dec 11, 2018 | Option Exercise | $19.25 | 24,750 | 476,438 | 51,648 | Dec 13, 2018, 06:25 PM |
| Cole G Bradley | CFO | Dec 11, 2018 | Option Exercise | $21.05 | 15,000 | 315,700 | 59,047 | Dec 13, 2018, 06:24 PM |
| Cole G Bradley | CFO | Dec 11, 2018 | Sale | $71.95 | 15,000 | 1,079,219 | 56,518 | Dec 13, 2018, 06:24 PM |
| BAKER BROS. ADVISORS LP | Director | Dec 12, 2018 | Sale | $73.09 | 18,500 | 1,352,087 | 9,683,746 | Dec 12, 2018, 05:57 PM |
| BAKER BROS. ADVISORS LP | Director | Dec 11, 2018 | Sale | $74.07 | 57,554 | 4,262,823 | 9,711,616 | Dec 12, 2018, 05:57 PM |
| BAKER BROS. ADVISORS LP | Director | Dec 10, 2018 | Sale | $73.83 | 9,366 | 691,483 | 9,746,410 | Dec 12, 2018, 05:57 PM |
| BAKER BROS. ADVISORS LP | Director | Dec 07, 2018 | Sale | $76.15 | 102,455 | 7,802,358 | 9,754,128 | Dec 07, 2018, 05:16 PM |
| BAKER BROS. ADVISORS LP | Director | Dec 06, 2018 | Sale | $75.46 | 92,679 | 6,993,622 | 9,838,546 | Dec 07, 2018, 05:16 PM |
| BAKER BROS. ADVISORS LP | Director | Dec 04, 2018 | Sale | $75.62 | 32,776 | 2,478,447 | 9,941,545 | Dec 07, 2018, 05:15 PM |
| Vaughn James J | Chief Commercial Officer | Dec 06, 2018 | Option Exercise | $31.12 | 3,000 | 93,360 | 20,763 | Dec 07, 2018, 05:03 PM |
| Vaughn James J | Chief Commercial Officer | Dec 06, 2018 | Sale | $75.30 | 3,000 | 225,888 | 20,463 | Dec 07, 2018, 05:03 PM |
| Shak Steven | Chief Scientific Officer | Dec 03, 2018 | Option Exercise | $17.33 | 1,500 | 25,995 | 338,241 | Dec 06, 2018, 07:47 PM |
| Shak Steven | Chief Scientific Officer | Dec 03, 2018 | Sale | $78.18 | 1,500 | 117,273 | 338,128 | Dec 06, 2018, 07:47 PM |
| BAKER BROS. ADVISORS LP | Director | Dec 03, 2018 | Sale | $78.49 | 202,134 | 15,865,833 | 10,063,808 | Dec 03, 2018, 05:40 PM |
| BAKER BROS. ADVISORS LP | Director | Nov 30, 2018 | Sale | $79.20 | 204,757 | 16,217,023 | 10,237,588 | Dec 03, 2018, 05:39 PM |
| BAKER BROS. ADVISORS LP | Director | Nov 29, 2018 | Sale | $77.95 | 51,278 | 3,997,192 | 10,307,436 | Dec 03, 2018, 05:39 PM |
| BAKER BROS. ADVISORS LP | Director | Nov 28, 2018 | Sale | $75.61 | 250,392 | 18,932,284 | 10,468,980 | Nov 28, 2018, 05:44 PM |
| BAKER BROS. ADVISORS LP | Director | Nov 27, 2018 | Sale | $74.09 | 138,610 | 10,269,089 | 10,562,396 | Nov 28, 2018, 05:42 PM |
| BAKER BROS. ADVISORS LP | Director | Nov 26, 2018 | Sale | $74.28 | 39,675 | 2,947,113 | 10,648,158 | Nov 28, 2018, 05:42 PM |
| BAKER BROS. ADVISORS LP | Director | Nov 16, 2018 | Sale | $76.65 | 87,395 | 6,699,000 | 10,728,010 | Nov 20, 2018, 05:06 PM |
| Popovits Kimberly J | President and CEO | Nov 16, 2018 | Sale | $76.72 | 10,000 | 767,171 | 171,127 | Nov 20, 2018, 04:45 PM |
| Popovits Kimberly J | President and CEO | Nov 16, 2018 | Option Exercise | $22.98 | 15,000 | 344,700 | 191,982 | Nov 19, 2018, 09:27 PM |
| Popovits Kimberly J | President and CEO | Nov 15, 2018 | Option Exercise | $22.98 | 25,000 | 574,500 | 201,982 | Nov 19, 2018, 09:27 PM |
| Popovits Kimberly J | President and CEO | Nov 16, 2018 | Sale | $76.72 | 15,000 | 1,150,793 | 183,321 | Nov 19, 2018, 09:27 PM |
| Popovits Kimberly J | President and CEO | Nov 15, 2018 | Sale | $77.18 | 25,000 | 1,929,560 | 196,982 | Nov 19, 2018, 09:27 PM |
| Cole G Bradley | CFO | Nov 13, 2018 | Option Exercise | $19.60 | 8,576 | 168,076 | 53,948 | Nov 15, 2018, 04:04 PM |
| Cole G Bradley | CFO | Nov 13, 2018 | Sale | $79.18 | 8,576 | 679,027 | 51,131 | Nov 15, 2018, 04:04 PM |
| Shak Steven | Chief Scientific Officer | Nov 09, 2018 | Option Exercise | $17.33 | 5,500 | 95,315 | 342,241 | Nov 14, 2018, 08:13 PM |
| Shak Steven | Chief Scientific Officer | Nov 09, 2018 | Sale | $83.21 | 5,500 | 457,646 | 339,484 | Nov 14, 2018, 08:13 PM |
| BAKER BROS. ADVISORS LP | Director | Nov 13, 2018 | Sale | $79.69 | 114,858 | 9,153,058 | 10,786,282 | Nov 13, 2018, 06:35 PM |
| BAKER BROS. ADVISORS LP | Director | Nov 13, 2018 | Sale | $78.50 | 138,712 | 10,889,359 | 10,938,575 | Nov 13, 2018, 06:33 PM |
| BAKER BROS. ADVISORS LP | Director | Nov 12, 2018 | Sale | $81.07 | 65,588 | 5,317,265 | 11,000,100 | Nov 13, 2018, 06:33 PM |
| BAKER BROS. ADVISORS LP | Director | Nov 12, 2018 | Sale | $80.38 | 14,415 | 1,158,724 | 11,007,633 | Nov 13, 2018, 06:32 PM |
| BAKER BROS. ADVISORS LP | Director | Nov 09, 2018 | Sale | $82.51 | 169,344 | 13,972,201 | 11,150,887 | Nov 13, 2018, 06:32 PM |
| BAKER BROS. ADVISORS LP | Director | Nov 09, 2018 | Sale | $83.71 | 107,738 | 9,018,337 | 11,243,695 | Nov 13, 2018, 06:29 PM |
| Vaughn James J | Chief Commercial Officer | Nov 08, 2018 | Option Exercise | $31.12 | 3,000 | 93,360 | 20,542 | Nov 13, 2018, 06:29 PM |
| Vaughn James J | Chief Commercial Officer | Nov 08, 2018 | Sale | $85.18 | 3,000 | 255,545 | 19,442 | Nov 13, 2018, 06:29 PM |
| Cohen Fred E | Director | Nov 08, 2018 | Option Exercise | $27.75 | 10,000 | 277,500 | 77,464 | Nov 13, 2018, 06:27 PM |
| Cohen Fred E | Director | Nov 08, 2018 | Sale | $87.93 | 10,000 | 879,262 | 76,628 | Nov 13, 2018, 06:27 PM |
| BAKER BROS. ADVISORS LP | Director | Nov 08, 2018 | Sale | $86.50 | 76,273 | 6,597,504 | 11,280,104 | Nov 13, 2018, 06:26 PM |
| BAKER BROS. ADVISORS LP | Director | Nov 08, 2018 | Sale | $85.58 | 72,745 | 6,225,158 | 11,354,802 | Nov 13, 2018, 06:22 PM |
| Pla Frederic | COO | Nov 07, 2018 | Option Exercise | $27.08 | 43,500 | 1,177,796 | 79,038 | Nov 09, 2018, 04:02 PM |
| Pla Frederic | COO | Nov 07, 2018 | Sale | $84.91 | 43,500 | 3,693,589 | 76,938 | Nov 09, 2018, 04:02 PM |
| Popovits Kimberly J | President and CEO | Oct 15, 2018 | Option Exercise | $22.98 | 25,000 | 574,500 | 201,982 | Oct 17, 2018, 05:52 PM |
| Popovits Kimberly J | President and CEO | Oct 16, 2018 | Option Exercise | $22.98 | 25,000 | 574,500 | 201,982 | Oct 17, 2018, 05:52 PM |
| Popovits Kimberly J | President and CEO | Oct 15, 2018 | Sale | $64.31 | 25,000 | 1,607,641 | 178,262 | Oct 17, 2018, 05:52 PM |
| Popovits Kimberly J | President and CEO | Oct 16, 2018 | Sale | $66.26 | 25,000 | 1,656,524 | 199,187 | Oct 17, 2018, 05:52 PM |
| Shak Steven | Chief Scientific Officer | Oct 09, 2018 | Option Exercise | $17.33 | 5,500 | 95,315 | 342,241 | Oct 11, 2018, 07:59 PM |
| Shak Steven | Chief Scientific Officer | Oct 09, 2018 | Sale | $64.35 | 5,500 | 353,950 | 337,841 | Oct 11, 2018, 07:59 PM |
| Cole G Bradley | CFO | Oct 10, 2018 | Option Exercise | $17.18 | 5,000 | 85,900 | 50,372 | Oct 11, 2018, 07:58 PM |
| Cole G Bradley | CFO | Oct 10, 2018 | Sale | $63.19 | 5,000 | 315,955 | 48,021 | Oct 11, 2018, 07:58 PM |
| Pla Frederic | COO | Oct 08, 2018 | Option Exercise | $27.00 | 1,500 | 40,500 | 37,038 | Oct 10, 2018, 06:04 PM |
| Pla Frederic | COO | Oct 08, 2018 | Sale | $65.43 | 1,500 | 98,148 | 35,938 | Oct 10, 2018, 06:04 PM |
| Vaughn James J | Chief Commercial Officer | Oct 09, 2018 | Option Exercise | $27.50 | 25,000 | 687,560 | 42,542 | Oct 10, 2018, 06:02 PM |
| Vaughn James J | Chief Commercial Officer | Oct 08, 2018 | Option Exercise | $30.41 | 25,000 | 760,154 | 42,542 | Oct 10, 2018, 06:02 PM |
| Vaughn James J | Chief Commercial Officer | Oct 09, 2018 | Sale | $64.37 | 25,000 | 1,609,325 | 23,272 | Oct 10, 2018, 06:02 PM |
| Vaughn James J | Chief Commercial Officer | Oct 08, 2018 | Sale | $65.34 | 25,000 | 1,633,518 | 26,327 | Oct 10, 2018, 06:02 PM |
| FUCHS HENRY J | Director | Oct 01, 2018 | Option Exercise | $70.18 | 142 | 9,966 | 6,177 | Oct 03, 2018, 08:32 PM |
| Cohen Fred E | Director | Oct 01, 2018 | Option Exercise | $70.18 | 142 | 9,966 | 67,464 | Oct 03, 2018, 08:13 PM |
| GRAHAM GINGER L | Director | Oct 01, 2018 | Option Exercise | $70.18 | 142 | 9,966 | 26,898 | Oct 03, 2018, 08:12 PM |
| BAKER BROS. ADVISORS LP | Director | Oct 01, 2018 | Option Exercise | $70.18 | 1,704 | 119,587 | 11,370,600 | Oct 03, 2018, 07:43 PM |
| Cole G Bradley | COO | Sep 11, 2018 | Option Exercise | $17.18 | 5,000 | 85,900 | 50,372 | Sep 13, 2018, 06:48 PM |
| Cole G Bradley | COO | Sep 11, 2018 | Sale | $64.01 | 5,000 | 320,074 | 46,972 | Sep 13, 2018, 06:48 PM |
| Pla Frederic | Chief Bus & Prod Dev Officer | Sep 10, 2018 | Option Exercise | $27.00 | 1,500 | 40,500 | 37,038 | Sep 11, 2018, 07:40 PM |
| Pla Frederic | Chief Bus & Prod Dev Officer | Sep 10, 2018 | Sale | $62.98 | 1,500 | 94,467 | 35,938 | Sep 11, 2018, 07:40 PM |
| Shak Steven | Chief Scientific Officer | Sep 10, 2018 | Option Exercise | $27.33 | 5,500 | 150,315 | 342,241 | Sep 11, 2018, 07:38 PM |
| Shak Steven | Chief Scientific Officer | Sep 10, 2018 | Sale | $63.05 | 5,500 | 346,794 | 338,604 | Sep 11, 2018, 07:38 PM |
| Cohen Fred E | Director | Sep 06, 2018 | Option Exercise | $34.44 | 8,250 | 284,130 | 75,572 | Sep 10, 2018, 05:02 PM |
| Cohen Fred E | Director | Sep 06, 2018 | Sale | $61.51 | 8,250 | 507,453 | 67,322 | Sep 10, 2018, 05:02 PM |
| Popovits Kimberly J | President and CEO | Aug 14, 2018 | Sale | $52.60 | 60,000 | 3,156,203 | 228,532 | Aug 16, 2018, 04:23 PM |
| Shak Steven | Chief Scientific Officer | Aug 09, 2018 | Option Exercise | $17.33 | 5,500 | 95,315 | 342,241 | Aug 10, 2018, 06:47 PM |
| Shak Steven | Chief Scientific Officer | Aug 09, 2018 | Sale | $55.92 | 5,500 | 307,576 | 339,241 | Aug 10, 2018, 06:47 PM |
| Pla Frederic | Chief Bus & Prod Dev Officer | Aug 09, 2018 | Option Exercise | $27.00 | 1,500 | 40,500 | 41,038 | Aug 10, 2018, 06:45 PM |
| Pla Frederic | Chief Bus & Prod Dev Officer | Aug 09, 2018 | Sale | $55.93 | 5,500 | 307,625 | 40,238 | Aug 10, 2018, 06:45 PM |
| Cole G Bradley | COO | Aug 09, 2018 | Option Exercise | $17.18 | 8,529 | 146,528 | 53,901 | Aug 10, 2018, 06:41 PM |
| Cole G Bradley | COO | Aug 09, 2018 | Sale | $55.94 | 8,529 | 477,105 | 49,390 | Aug 10, 2018, 06:41 PM |
| Cole G Bradley | COO | Mar 08, 2017 | Option Exercise | $23.31 | 100 | 2,331 | 39,828 | Aug 10, 2018, 06:39 PM |
| Radford Jason W. | Chief Legal Officer | Aug 08, 2018 | Sale | $56.39 | 4,126 | 232,681 | 34,750 | Aug 10, 2018, 06:36 PM |
| Cohen Fred E | Director | Aug 07, 2018 | Option Exercise | $25.79 | 8,250 | 212,768 | 75,572 | Aug 09, 2018, 07:47 PM |
| Cohen Fred E | Director | Aug 07, 2018 | Sale | $56.22 | 8,250 | 463,800 | 68,722 | Aug 09, 2018, 07:47 PM |
| GRAHAM GINGER L | Director | Aug 06, 2018 | Option Exercise | $17.33 | 16,500 | 285,945 | 26,756 | Aug 08, 2018, 04:28 PM |
| Popovits Kimberly J | President and CEO | Jul 16, 2018 | Option Exercise | $17.18 | 10,000 | 171,800 | 246,157 | Jul 18, 2018, 04:40 PM |
| Popovits Kimberly J | President and CEO | Jul 16, 2018 | Sale | $53.27 | 10,000 | 532,685 | 243,158 | Jul 18, 2018, 04:40 PM |
| Shak Steven | Chief Scientific Officer | Jul 09, 2018 | Option Exercise | $17.33 | 5,500 | 95,315 | 341,416 | Jul 10, 2018, 05:18 PM |
| Shak Steven | Chief Scientific Officer | Jul 09, 2018 | Sale | $49.56 | 5,500 | 272,554 | 335,916 | Jul 10, 2018, 05:18 PM |
| Cohen Fred E | Director | Jul 01, 2018 | Option Exercise | $50.40 | 198 | 9,979 | 67,322 | Jul 03, 2018, 04:03 PM |
| GRAHAM GINGER L | Director | Jul 01, 2018 | Option Exercise | $50.40 | 198 | 9,979 | 10,256 | Jul 03, 2018, 04:02 PM |
| FUCHS HENRY J | Director | Jul 01, 2018 | Option Exercise | $50.40 | 198 | 9,979 | 6,035 | Jul 03, 2018, 04:01 PM |
| BAKER BROS. ADVISORS LP | Director | Jul 01, 2018 | Option Exercise | $50.40 | 2,376 | 119,750 | 11,370,316 | Jul 03, 2018, 12:00 AM |
| Popovits Kimberly J | President and CEO | Jun 14, 2018 | Option Exercise | $17.18 | 10,000 | 171,800 | 246,157 | Jun 18, 2018, 07:16 PM |
| Popovits Kimberly J | President and CEO | Jun 14, 2018 | Sale | $48.89 | 10,000 | 488,916 | 236,557 | Jun 18, 2018, 07:16 PM |
| Shak Steven | Chief Scientific Officer | Jun 11, 2018 | Option Exercise | $17.33 | 5,500 | 95,315 | 341,416 | Jun 13, 2018, 06:59 PM |
| Shak Steven | Chief Scientific Officer | Jun 11, 2018 | Sale | $50.22 | 5,500 | 276,200 | 336,425 | Jun 13, 2018, 06:59 PM |
| Vaughn James J | Chief Commercial Officer | Jun 04, 2018 | Option Exercise | $25.98 | 80,768 | 2,097,997 | 49,655 | Jun 06, 2018, 07:57 PM |
| Vaughn James J | Chief Commercial Officer | Jun 04, 2018 | Sale | $45.78 | 93,414 | 4,276,165 | 42,103 | Jun 06, 2018, 07:57 PM |
| Radford Jason W. | Chief Legal Officer | May 15, 2018 | Option Exercise | $38.00 | 1,153 | 43,814 | 37,667 | May 16, 2018, 08:23 PM |
| Popovits Kimberly J | President and CEO | May 14, 2018 | Option Exercise | $17.18 | 10,000 | 171,800 | 246,157 | May 16, 2018, 06:41 PM |
| Popovits Kimberly J | President and CEO | May 14, 2018 | Sale | $38.09 | 10,000 | 380,877 | 241,157 | May 16, 2018, 06:41 PM |
| Shak Steven | Chief Scientific Officer | May 09, 2018 | Option Exercise | $17.33 | 5,500 | 95,315 | 341,416 | May 11, 2018, 03:10 PM |
| Shak Steven | Chief Scientific Officer | May 09, 2018 | Sale | $36.64 | 5,500 | 201,543 | 338,491 | May 11, 2018, 03:10 PM |
| Vaughn James J | Chief Commercial Officer | May 02, 2018 | Sale | $32.50 | 1,497 | 48,653 | 29,655 | May 04, 2018, 08:59 PM |
| Popovits Kimberly J | President and CEO | Apr 16, 2018 | Option Exercise | $17.18 | 15,000 | 257,700 | 251,157 | Apr 18, 2018, 04:33 PM |
| Popovits Kimberly J | President and CEO | Apr 16, 2018 | Sale | $33.19 | 15,000 | 497,880 | 236,157 | Apr 18, 2018, 04:33 PM |
| FUCHS HENRY J | Director | Apr 01, 2018 | Option Exercise | $31.29 | 319 | 9,982 | 5,837 | Apr 03, 2018, 08:32 PM |
| Cohen Fred E | Director | Apr 01, 2018 | Option Exercise | $31.29 | 319 | 9,982 | 67,124 | Apr 03, 2018, 08:32 PM |
| GRAHAM GINGER L | Director | Apr 01, 2018 | Option Exercise | $31.29 | 319 | 9,982 | 10,058 | Apr 03, 2018, 08:31 PM |
| BAKER BROS. ADVISORS LP | Director | Apr 01, 2018 | Option Exercise | $31.29 | 3,828 | 119,778 | 11,369,920 | Apr 03, 2018, 06:01 PM |
| Popovits Kimberly J | President and CEO | Mar 14, 2018 | Option Exercise | $17.18 | 5,000 | 85,900 | 241,157 | Mar 16, 2018, 06:54 PM |
| Popovits Kimberly J | President and CEO | Mar 14, 2018 | Sale | $32.01 | 5,000 | 160,048 | 236,157 | Mar 16, 2018, 06:54 PM |
| Cole G Bradley | COO | Mar 13, 2018 | Option Exercise | $17.33 | 5,000 | 86,650 | 49,754 | Mar 15, 2018, 04:31 PM |
| Cole G Bradley | COO | Mar 13, 2018 | Sale | $32.80 | 5,000 | 164,014 | 45,054 | Mar 15, 2018, 04:31 PM |
| BAKER BROS. ADVISORS LP | Director | Mar 09, 2018 | Option Exercise | $18.50 | 49,500 | 915,750 | 11,369,282 | Mar 12, 2018, 06:04 PM |
| Leber Laura | Chief Communication Officer | Feb 20, 2018 | Sale | $32.92 | 3,374 | 111,080 | 16,731 | Feb 22, 2018, 04:24 PM |
| Febbo Phillip G. | Chief Medical Officer | Feb 20, 2018 | Sale | $32.84 | 4,942 | 162,290 | 21,687 | Feb 22, 2018, 04:19 PM |
| Cole G Bradley | COO | Feb 20, 2018 | Option Exercise | $17.33 | 5,000 | 86,650 | 49,754 | Feb 22, 2018, 04:19 PM |
| Cole G Bradley | COO | Feb 20, 2018 | Sale | $32.89 | 5,000 | 164,474 | 44,954 | Feb 22, 2018, 04:19 PM |
| Pla Frederic | Chief Bus & Prod Dev Officer | Feb 15, 2018 | Option Exercise | $32.66 | 3,600 | 117,576 | 38,712 | Feb 20, 2018, 06:40 PM |
| Radford Jason W. | Chief Legal Officer | Feb 15, 2018 | Option Exercise | $32.66 | 2,065 | 67,443 | 38,820 | Feb 20, 2018, 05:59 PM |
| McEachron Kim | Chief People Officer | Feb 15, 2018 | Option Exercise | $32.66 | 2,221 | 72,538 | 33,727 | Feb 20, 2018, 05:59 PM |
| Leber Laura | Chief Communication Officer | Feb 15, 2018 | Option Exercise | $32.66 | 1,999 | 65,287 | 19,905 | Feb 20, 2018, 05:58 PM |
| Febbo Phillip G. | Chief Medical Officer | Feb 15, 2018 | Option Exercise | $32.66 | 2,801 | 91,481 | 26,329 | Feb 20, 2018, 05:57 PM |
| Vaughn James J | Chief Commercial Officer | Feb 15, 2018 | Option Exercise | $32.66 | 3,115 | 101,736 | 31,152 | Feb 20, 2018, 05:56 PM |
| Pla Frederic | Chief Bus & Prod Dev Officer | Feb 15, 2018 | Option Exercise | $32.66 | 3,600 | 117,576 | 38,712 | Feb 20, 2018, 05:55 PM |
| Shak Steven | Chief Scientific Officer | Feb 15, 2018 | Option Exercise | $32.66 | 2,825 | 92,264 | 335,916 | Feb 20, 2018, 05:55 PM |
| Cole G Bradley | COO | Feb 15, 2018 | Option Exercise | $32.66 | 3,182 | 103,924 | 44,754 | Feb 20, 2018, 05:54 PM |
| Popovits Kimberly J | President and CEO | Feb 15, 2018 | Option Exercise | $32.66 | 6,232 | 203,537 | 59,617 | Feb 20, 2018, 05:53 PM |
| Popovits Kimberly J | President and CEO | Feb 14, 2018 | Option Exercise | $17.18 | 10,000 | 171,800 | 75,849 | Feb 15, 2018, 04:02 PM |
| Popovits Kimberly J | President and CEO | Feb 14, 2018 | Sale | $32.93 | 10,000 | 329,336 | 65,849 | Feb 15, 2018, 04:02 PM |
| Popovits Kimberly J | President and CEO | Jan 16, 2018 | Option Exercise | $17.18 | 10,000 | 171,800 | 51,719 | Jan 18, 2018, 09:30 PM |
| Popovits Kimberly J | President and CEO | Jan 16, 2018 | Sale | $34.99 | 10,000 | 349,885 | 41,919 | Jan 18, 2018, 09:30 PM |
| Cole G Bradley | COO | Jan 09, 2018 | Option Exercise | $17.33 | 5,000 | 86,650 | 45,346 | Jan 10, 2018, 09:17 PM |
| Cole G Bradley | COO | Jan 09, 2018 | Sale | $35.51 | 5,000 | 177,565 | 40,346 | Jan 10, 2018, 09:17 PM |
| Vaughn James J | Chief Commercial Officer | Jan 02, 2018 | Option Exercise | $17.33 | 2,169 | 37,589 | 30,481 | Jan 04, 2018, 07:54 PM |
| Vaughn James J | Chief Commercial Officer | Jan 02, 2018 | Sale | $34.09 | 3,004 | 102,406 | 28,312 | Jan 04, 2018, 07:54 PM |
| Cohen Fred E | Director | Jan 01, 2018 | Option Exercise | $34.20 | 292 | 9,986 | 66,805 | Jan 03, 2018, 06:22 PM |
| FUCHS HENRY J | Director | Jan 01, 2018 | Option Exercise | $34.20 | 292 | 9,986 | 5,518 | Jan 03, 2018, 06:22 PM |
| GRAHAM GINGER L | Director | Jan 01, 2018 | Option Exercise | $34.20 | 292 | 9,986 | 9,739 | Jan 03, 2018, 06:21 PM |
| BAKER BROS. ADVISORS LP | Director | Jan 01, 2018 | Option Exercise | $34.20 | 3,504 | 119,837 | 11,361,032 | Jan 03, 2018, 12:00 AM |
| Febbo Phillip G. | Chief Medical Officer | Dec 19, 2017 | Option Exercise | $27.00 | 5,000 | 135,000 | 23,134 | Dec 20, 2017, 04:35 PM |
| Febbo Phillip G. | Chief Medical Officer | Dec 19, 2017 | Sale | $36.99 | 5,334 | 197,298 | 18,134 | Dec 20, 2017, 04:35 PM |
| Leber Laura | Chief Communication Officer | Dec 14, 2017 | Option Exercise | $21.52 | 12,000 | 258,240 | 27,754 | Dec 18, 2017, 07:52 PM |
| Leber Laura | Chief Communication Officer | Dec 15, 2017 | Option Exercise | $17.33 | 9,000 | 155,970 | 24,754 | Dec 18, 2017, 07:52 PM |
| Leber Laura | Chief Communication Officer | Dec 14, 2017 | Sale | $32.00 | 12,000 | 384,000 | 15,754 | Dec 18, 2017, 07:52 PM |
| Leber Laura | Chief Communication Officer | Dec 15, 2017 | Sale | $35.00 | 9,000 | 315,000 | 15,754 | Dec 18, 2017, 07:52 PM |
| Popovits Kimberly J | President and CEO | Dec 14, 2017 | Option Exercise | $17.28 | 20,000 | 345,535 | 61,919 | Dec 18, 2017, 07:51 PM |
| Popovits Kimberly J | President and CEO | Dec 14, 2017 | Sale | $31.50 | 20,000 | 630,000 | 51,919 | Dec 18, 2017, 07:51 PM |
| Cole G Bradley | COO | Dec 12, 2017 | Option Exercise | $17.33 | 5,000 | 86,650 | 45,346 | Dec 14, 2017, 07:03 PM |
| Cole G Bradley | COO | Dec 12, 2017 | Sale | $29.94 | 5,000 | 149,708 | 40,346 | Dec 14, 2017, 07:03 PM |
| Cole G Bradley | COO | Dec 12, 2017 | Option Exercise | $17.33 | 5,000 | 86,650 | 44,935 | Dec 13, 2017, 04:14 PM |
| Cole G Bradley | COO | Dec 12, 2017 | Sale | $29.94 | 5,000 | 149,708 | 39,935 | Dec 13, 2017, 04:14 PM |
| Cole G Bradley | COO | Nov 07, 2017 | Option Exercise | $17.33 | 5,000 | 86,650 | 44,935 | Nov 09, 2017, 04:59 PM |
| Cole G Bradley | COO | Nov 07, 2017 | Sale | $31.47 | 5,000 | 157,330 | 39,935 | Nov 09, 2017, 04:59 PM |
| Vaughn James J | Chief Commercial Officer | Nov 01, 2017 | Option Exercise | $17.33 | 3,907 | 67,708 | 33,692 | Nov 08, 2017, 05:29 PM |
| Vaughn James J | Chief Commercial Officer | Nov 02, 2017 | Option Exercise | $17.33 | 924 | 16,013 | 28,999 | Nov 08, 2017, 05:29 PM |
| Vaughn James J | Chief Commercial Officer | Nov 02, 2017 | Sale | $32.51 | 1,379 | 44,827 | 28,175 | Nov 08, 2017, 05:29 PM |
| Vaughn James J | Chief Commercial Officer | Nov 01, 2017 | Sale | $32.58 | 5,617 | 183,001 | 31,282 | Nov 08, 2017, 05:29 PM |
| Cole G Bradley | COO | Oct 10, 2017 | Option Exercise | $17.33 | 5,000 | 86,650 | 44,935 | Oct 11, 2017, 05:55 PM |
| Cole G Bradley | COO | Oct 10, 2017 | Sale | $31.93 | 5,000 | 159,636 | 39,935 | Oct 11, 2017, 05:55 PM |
| FUCHS HENRY J | Director | Oct 01, 2017 | Option Exercise | $32.09 | 311 | 9,980 | 5,226 | Oct 03, 2017, 06:17 PM |
| Cohen Fred E | Director | Oct 01, 2017 | Option Exercise | $32.09 | 311 | 9,980 | 66,513 | Oct 03, 2017, 06:16 PM |
| GRAHAM GINGER L | Director | Oct 01, 2017 | Option Exercise | $32.09 | 311 | 9,980 | 9,447 | Oct 03, 2017, 06:15 PM |
| BAKER BROS. ADVISORS LP | Director | Oct 01, 2017 | Option Exercise | $32.09 | 3,732 | 119,760 | 11,360,448 | Oct 03, 2017, 05:39 PM |
| Popovits Kimberly J | President and CEO | Sep 14, 2017 | Option Exercise | $17.33 | 5,000 | 86,650 | 46,132 | Sep 18, 2017, 04:02 PM |
| Popovits Kimberly J | President and CEO | Sep 14, 2017 | Sale | $31.00 | 5,000 | 154,989 | 41,132 | Sep 18, 2017, 04:02 PM |
| Cole G Bradley | COO | Sep 12, 2017 | Option Exercise | $17.33 | 5,000 | 86,650 | 44,935 | Sep 14, 2017, 05:12 PM |
| Cole G Bradley | COO | Sep 12, 2017 | Sale | $31.86 | 5,000 | 159,288 | 39,935 | Sep 14, 2017, 05:12 PM |
| Popovits Kimberly J | President and CEO | Aug 14, 2017 | Option Exercise | $17.33 | 5,000 | 86,650 | 84,057 | Aug 16, 2017, 08:02 PM |
| Popovits Kimberly J | President and CEO | Aug 14, 2017 | Sale | $30.22 | 5,000 | 151,111 | 79,057 | Aug 16, 2017, 08:02 PM |
| Vaughn James J | Chief Commercial Officer | Aug 08, 2017 | Option Exercise | $23.31 | 6,500 | 151,515 | 37,785 | Aug 09, 2017, 07:52 PM |
| Vaughn James J | Chief Commercial Officer | Aug 08, 2017 | Sale | $30.59 | 8,000 | 244,724 | 29,785 | Aug 09, 2017, 07:52 PM |
| Cole G Bradley | COO | Aug 08, 2017 | Option Exercise | $17.33 | 5,000 | 86,650 | 44,935 | Aug 09, 2017, 07:51 PM |
| Cole G Bradley | COO | Aug 08, 2017 | Sale | $30.57 | 5,000 | 152,845 | 39,935 | Aug 09, 2017, 07:51 PM |
| Febbo Phillip G. | Chief Medical Officer | Jul 19, 2017 | Sale | $33.57 | 3,174 | 106,538 | 18,130 | Jul 21, 2017, 04:20 PM |
| Cole G Bradley | COO | Jul 11, 2017 | Option Exercise | $17.33 | 5,000 | 86,650 | 44,935 | Jul 13, 2017, 05:23 PM |
| Cole G Bradley | COO | Jul 11, 2017 | Sale | $32.53 | 5,000 | 162,667 | 40,008 | Jul 13, 2017, 05:23 PM |
| Popovits Kimberly J | President and CEO | Jul 05, 2017 | Option Exercise | $17.33 | 1,468 | 25,440 | 80,525 | Jul 06, 2017, 07:28 PM |
| Popovits Kimberly J | President and CEO | Jul 03, 2017 | Option Exercise | $17.33 | 3,532 | 61,210 | 82,589 | Jul 06, 2017, 07:28 PM |
| Popovits Kimberly J | President and CEO | Jul 05, 2017 | Sale | $32.67 | 1,468 | 47,952 | 79,057 | Jul 06, 2017, 07:28 PM |
| Popovits Kimberly J | President and CEO | Jul 03, 2017 | Sale | $32.56 | 3,532 | 114,988 | 79,057 | Jul 06, 2017, 07:28 PM |
| FUCHS HENRY J | Director | Jul 01, 2017 | Option Exercise | $32.55 | 307 | 9,993 | 4,915 | Jul 05, 2017, 07:04 PM |
| Cohen Fred E | Director | Jul 01, 2017 | Option Exercise | $32.55 | 307 | 9,993 | 66,202 | Jul 05, 2017, 07:03 PM |
| GRAHAM GINGER L | Director | Jul 01, 2017 | Option Exercise | $32.55 | 307 | 9,993 | 9,136 | Jul 05, 2017, 07:03 PM |
| BAKER BROS. ADVISORS LP | Director | Jul 01, 2017 | Option Exercise | $32.55 | 3,684 | 119,914 | 11,359,826 | Jul 05, 2017, 06:19 PM |
| Shak Steven | Chief Scientific Officer | Jun 23, 2017 | Option Exercise | $23.31 | 5,000 | 116,550 | 336,924 | Jun 27, 2017, 06:11 PM |
| Shak Steven | Chief Scientific Officer | Jun 23, 2017 | Sale | $33.27 | 5,000 | 166,371 | 331,924 | Jun 27, 2017, 06:11 PM |
| Cole G Bradley | COO | Jun 13, 2017 | Option Exercise | $17.33 | 5,000 | 86,650 | 44,935 | Jun 15, 2017, 04:40 PM |
| Cole G Bradley | COO | Jun 13, 2017 | Sale | $31.67 | 5,000 | 158,342 | 39,935 | Jun 15, 2017, 04:40 PM |
| Popovits Kimberly J | President and CEO | Jun 05, 2017 | Option Exercise | $17.33 | 5,000 | 86,650 | 84,057 | Jun 07, 2017, 07:07 PM |
| Popovits Kimberly J | President and CEO | Jun 05, 2017 | Sale | $32.32 | 5,000 | 161,582 | 79,057 | Jun 07, 2017, 07:07 PM |
| BAKER BROS. ADVISORS LP | Director | May 31, 2017 | Option Exercise | $18.13 | 49,500 | 897,435 | 11,359,212 | Jun 01, 2017, 05:19 PM |
| Shak Steven | Chief Scientific Officer | May 23, 2017 | Option Exercise | $23.31 | 5,000 | 116,550 | 336,103 | May 25, 2017, 04:39 PM |
| Shak Steven | Chief Scientific Officer | May 23, 2017 | Sale | $29.40 | 5,000 | 146,981 | 331,103 | May 25, 2017, 04:39 PM |
| Cohen Fred E | Director | May 19, 2017 | Option Exercise | $14.37 | 8,250 | 118,552 | 74,145 | May 23, 2017, 08:16 PM |
| Cohen Fred E | Director | May 19, 2017 | Sale | $29.54 | 8,250 | 243,745 | 65,895 | May 23, 2017, 08:16 PM |
| Cohen Fred E | Director | May 18, 2017 | Option Exercise | $18.05 | 16,500 | 297,743 | 82,395 | May 22, 2017, 06:59 PM |
| Cohen Fred E | Director | May 18, 2017 | Sale | $29.88 | 16,500 | 493,040 | 65,895 | May 22, 2017, 06:59 PM |
| Cohen Fred E | Director | May 16, 2017 | Option Exercise | $18.13 | 8,250 | 149,572 | 74,145 | May 18, 2017, 07:52 PM |
| Cohen Fred E | Director | May 16, 2017 | Sale | $30.68 | 8,250 | 253,102 | 65,895 | May 18, 2017, 07:52 PM |
| Radford Jason W. | Chief Legal Officer | May 15, 2017 | Option Exercise | $30.81 | 1,253 | 38,605 | 24,902 | May 17, 2017, 07:42 PM |
| Popovits Kimberly J | President and CEO | May 03, 2017 | Option Exercise | $17.33 | 5,000 | 86,650 | 83,236 | May 04, 2017, 05:12 PM |
| Popovits Kimberly J | President and CEO | May 03, 2017 | Sale | $31.77 | 5,000 | 158,849 | 80,529 | May 04, 2017, 05:12 PM |
| Shak Steven | Chief Scientific Officer | Apr 24, 2017 | Option Exercise | $23.31 | 5,000 | 116,550 | 336,103 | Apr 26, 2017, 05:09 PM |
| Shak Steven | Chief Scientific Officer | Apr 24, 2017 | Sale | $31.46 | 5,000 | 157,323 | 331,103 | Apr 26, 2017, 05:09 PM |
| Popovits Kimberly J | President and CEO | Apr 03, 2017 | Option Exercise | $20.80 | 5,000 | 103,992 | 83,236 | Apr 05, 2017, 05:25 PM |
| Popovits Kimberly J | President and CEO | Apr 03, 2017 | Sale | $31.30 | 5,000 | 156,507 | 78,236 | Apr 05, 2017, 05:25 PM |
| BAKER BROS. ADVISORS LP | Director | Apr 01, 2017 | Option Exercise | $31.49 | 3,804 | 119,788 | 11,350,962 | Apr 04, 2017, 07:32 PM |
| FUCHS HENRY J | Director | Apr 01, 2017 | Option Exercise | $31.49 | 317 | 9,982 | 4,608 | Apr 04, 2017, 05:28 PM |
| Cohen Fred E | Director | Apr 01, 2017 | Option Exercise | $31.49 | 317 | 9,982 | 65,895 | Apr 04, 2017, 05:27 PM |
| GRAHAM GINGER L | Director | Apr 01, 2017 | Option Exercise | $31.49 | 317 | 9,982 | 8,829 | Apr 04, 2017, 05:26 PM |
| Shak Steven | Chief Scientific Officer | Mar 23, 2017 | Option Exercise | $23.31 | 5,000 | 116,550 | 336,103 | Mar 24, 2017, 07:05 PM |
| Shak Steven | Chief Scientific Officer | Mar 23, 2017 | Sale | $31.26 | 5,000 | 156,294 | 331,103 | Mar 24, 2017, 07:05 PM |
| Leber Laura | Chief Communication Officer | Mar 20, 2017 | Sale | $31.88 | 3,072 | 97,941 | 14,627 | Mar 22, 2017, 04:03 PM |
| Cole G Bradley | COO | Mar 08, 2017 | Option Exercise | $23.31 | 5,710 | 133,100 | 45,338 | Mar 10, 2017, 06:21 PM |
| Cole G Bradley | COO | Mar 08, 2017 | Sale | $31.55 | 5,710 | 180,134 | 39,728 | Mar 10, 2017, 06:21 PM |
| Popovits Kimberly J | President and CEO | Mar 06, 2017 | Option Exercise | $23.31 | 290 | 6,760 | 78,526 | Mar 07, 2017, 08:34 PM |
| Popovits Kimberly J | President and CEO | Mar 03, 2017 | Option Exercise | $23.31 | 4,710 | 109,790 | 82,946 | Mar 07, 2017, 08:34 PM |
| Popovits Kimberly J | President and CEO | Mar 06, 2017 | Sale | $31.08 | 290 | 9,014 | 78,236 | Mar 07, 2017, 08:34 PM |
| Popovits Kimberly J | President and CEO | Mar 03, 2017 | Sale | $31.09 | 4,710 | 146,440 | 78,236 | Mar 07, 2017, 08:34 PM |
| Shak Steven | Chief Scientific Officer | Feb 23, 2017 | Option Exercise | $23.31 | 5,000 | 116,550 | 336,103 | Feb 27, 2017, 09:56 PM |
| Shak Steven | Chief Scientific Officer | Feb 23, 2017 | Sale | $29.36 | 5,000 | 146,815 | 331,103 | Feb 27, 2017, 09:56 PM |
| Vaughn James J | Chief Commercial Officer | Feb 15, 2017 | Option Exercise | $31.12 | 3,417 | 106,337 | 30,502 | Feb 17, 2017, 06:51 PM |
| Shak Steven | Chief Scientific Officer | Feb 15, 2017 | Option Exercise | $31.12 | 2,884 | 89,750 | 331,103 | Feb 17, 2017, 06:50 PM |
| Radford Jason W. | Chief Legal Officer | Feb 15, 2017 | Option Exercise | $31.12 | 771 | 23,994 | 26,155 | Feb 17, 2017, 06:49 PM |
| Popovits Kimberly J | President and CEO | Feb 15, 2017 | Option Exercise | $31.12 | 4,982 | 155,040 | 78,236 | Feb 17, 2017, 06:48 PM |
| Pla Frederic | Chief Bus & Prod Dev Officer | Feb 15, 2017 | Option Exercise | $31.12 | 2,882 | 89,688 | 31,700 | Feb 17, 2017, 06:47 PM |
| McEachron Kim | Chief People Officer | Feb 15, 2017 | Option Exercise | $31.12 | 2,197 | 68,371 | 27,620 | Feb 17, 2017, 06:46 PM |
| Leber Laura | Chief Communication Officer | Feb 15, 2017 | Option Exercise | $31.12 | 2,078 | 64,667 | 17,699 | Feb 17, 2017, 06:45 PM |
| Febbo Phillip G. | Chief Medical Officer | Feb 15, 2017 | Option Exercise | $31.12 | 1,910 | 59,439 | 23,139 | Feb 17, 2017, 06:44 PM |
| Febbo Phillip G. | Chief Medical Officer | Feb 16, 2017 | Sale | $30.09 | 2,495 | 75,064 | 21,870 | Feb 17, 2017, 06:44 PM |
| Cole G Bradley | COO | Feb 15, 2017 | Option Exercise | $31.12 | 3,294 | 102,509 | 39,728 | Feb 17, 2017, 06:43 PM |
| Cole G Bradley | COO | Feb 15, 2017 | Option Exercise | $23.31 | 5,000 | 116,550 | 48,022 | Feb 17, 2017, 06:43 PM |
| Cole G Bradley | COO | Feb 15, 2017 | Sale | $29.00 | 5,000 | 145,000 | 43,022 | Feb 17, 2017, 06:43 PM |
| Shak Steven | Chief Scientific Officer | Jan 23, 2017 | Option Exercise | $23.31 | 5,000 | 116,550 | 332,207 | Jan 25, 2017, 08:01 PM |
| Shak Steven | Chief Scientific Officer | Jan 23, 2017 | Sale | $27.28 | 5,000 | 136,387 | 327,207 | Jan 25, 2017, 08:01 PM |
| Cole G Bradley | COO | Jan 10, 2017 | Option Exercise | $23.31 | 5,000 | 116,550 | 40,882 | Jan 12, 2017, 05:39 PM |
| Cole G Bradley | COO | Jan 10, 2017 | Sale | $29.22 | 5,000 | 146,087 | 35,882 | Jan 12, 2017, 05:39 PM |
| GRAHAM GINGER L | Director | Jan 01, 2017 | Option Exercise | $29.39 | 340 | 9,993 | 8,512 | Jan 04, 2017, 07:19 PM |
| FUCHS HENRY J | Director | Jan 01, 2017 | Option Exercise | $29.39 | 340 | 9,993 | 4,291 | Jan 04, 2017, 07:18 PM |
| Cohen Fred E | Director | Jan 01, 2017 | Option Exercise | $29.39 | 340 | 9,993 | 65,578 | Jan 04, 2017, 07:17 PM |
| BAKER FELIX | Director | Jan 01, 2017 | Option Exercise | $29.39 | 4,080 | 119,911 | 11,350,328 | Jan 04, 2017, 06:30 PM |
| Radford Jason W. | Chief Legal Officer | May 15, 2016 | Option Exercise | $27.28 | 1,420 | 38,738 | 14,554 | Dec 20, 2016, 05:15 PM |
| Febbo Phillip G. | Chief Medical Officer | Aug 15, 2016 | Option Exercise | $27.00 | 1,066 | 28,782 | 13,241 | Dec 20, 2016, 05:14 PM |
| Febbo Phillip G. | Chief Medical Officer | Aug 15, 2015 | Option Exercise | $24.85 | 1,065 | 26,465 | 14,307 | Dec 20, 2016, 05:14 PM |
| Cole G Bradley | COO | Dec 06, 2016 | Option Exercise | $23.31 | 5,000 | 116,550 | 40,882 | Dec 08, 2016, 08:12 PM |
| Cole G Bradley | COO | Dec 06, 2016 | Sale | $30.61 | 5,000 | 153,029 | 35,882 | Dec 08, 2016, 08:12 PM |
| Popovits Kimberly J | President and CEO | Dec 05, 2016 | Option Exercise | $23.31 | 5,000 | 116,550 | 64,620 | Dec 06, 2016, 07:17 PM |
| Popovits Kimberly J | President and CEO | Dec 05, 2016 | Sale | $30.02 | 5,000 | 150,100 | 59,620 | Dec 06, 2016, 07:17 PM |
| Leber Laura | Chief Communication Officer | Nov 21, 2016 | Option Exercise | $17.41 | 3,600 | 62,676 | 21,399 | Nov 23, 2016, 02:43 PM |
| Leber Laura | Chief Communication Officer | Nov 21, 2016 | Sale | $31.73 | 7,068 | 224,266 | 17,799 | Nov 23, 2016, 02:43 PM |
| Shak Steven | Chief Scientific Officer | Nov 10, 2016 | Option Exercise | $18.89 | 5,000 | 94,450 | 330,534 | Nov 15, 2016, 04:56 PM |
| Shak Steven | Chief Scientific Officer | Nov 10, 2016 | Sale | $31.71 | 5,000 | 158,569 | 327,207 | Nov 15, 2016, 04:56 PM |
| Cole G Bradley | COO | Nov 08, 2016 | Option Exercise | $23.31 | 5,000 | 116,550 | 40,426 | Nov 10, 2016, 07:37 PM |
| Cole G Bradley | COO | Nov 08, 2016 | Sale | $29.68 | 5,000 | 148,422 | 35,426 | Nov 10, 2016, 07:37 PM |
| Popovits Kimberly J | President and CEO | Nov 03, 2016 | Option Exercise | $18.89 | 5,313 | 100,363 | 64,933 | Nov 07, 2016, 06:53 PM |
| Popovits Kimberly J | President and CEO | Nov 03, 2016 | Sale | $28.88 | 5,313 | 153,423 | 59,620 | Nov 07, 2016, 06:53 PM |
| Shak Steven | Chief Scientific Officer | Oct 11, 2016 | Option Exercise | $18.89 | 5,000 | 94,450 | 332,207 | Oct 12, 2016, 07:24 PM |
| Shak Steven | Chief Scientific Officer | Oct 11, 2016 | Sale | $30.39 | 5,000 | 151,925 | 327,207 | Oct 12, 2016, 07:24 PM |
| Cole G Bradley | COO | Oct 10, 2016 | Option Exercise | $21.18 | 8,290 | 175,560 | 39,716 | Oct 12, 2016, 06:07 PM |
| Cole G Bradley | COO | Oct 10, 2016 | Sale | $30.59 | 8,290 | 253,572 | 35,426 | Oct 12, 2016, 06:07 PM |
| Vaughn James J | Chief Commercial Officer | Oct 06, 2016 | Sale | $29.68 | 3,000 | 89,042 | 26,079 | Oct 11, 2016, 08:07 PM |
| GRAHAM GINGER L | Director | Oct 01, 2016 | Option Exercise | $28.92 | 345 | 9,977 | 8,172 | Oct 04, 2016, 07:46 PM |
| FUCHS HENRY J | Director | Oct 01, 2016 | Option Exercise | $28.92 | 345 | 9,977 | 3,951 | Oct 04, 2016, 07:44 PM |
| Cohen Fred E | Director | Oct 01, 2016 | Option Exercise | $28.92 | 345 | 9,977 | 65,238 | Oct 04, 2016, 07:43 PM |
| BAKER FELIX | Director | Sep 30, 2016 | Option Exercise | $28.92 | 4,140 | 119,729 | 11,349,648 | Oct 04, 2016, 06:35 PM |
| Shak Steven | Chief Scientific Officer | Sep 13, 2016 | Option Exercise | $18.89 | 5,000 | 94,450 | 332,207 | Sep 15, 2016, 06:25 PM |
| Shak Steven | Chief Scientific Officer | Sep 13, 2016 | Sale | $26.83 | 5,000 | 134,156 | 327,207 | Sep 15, 2016, 06:25 PM |
| Cole G Bradley | COO | Sep 06, 2016 | Option Exercise | $18.89 | 4,000 | 75,560 | 39,426 | Sep 08, 2016, 06:36 PM |
| Cole G Bradley | COO | Sep 06, 2016 | Sale | $27.41 | 4,000 | 109,637 | 35,426 | Sep 08, 2016, 06:36 PM |
| Shak Steven | Chief Scientific Officer | Aug 23, 2016 | Option Exercise | $18.89 | 5,000 | 94,450 | 332,207 | Aug 25, 2016, 06:49 PM |
| Shak Steven | Chief Scientific Officer | Aug 23, 2016 | Sale | $27.24 | 5,000 | 136,215 | 327,207 | Aug 25, 2016, 06:49 PM |
| Cole G Bradley | COO | Aug 11, 2016 | Option Exercise | $18.89 | 5,000 | 94,450 | 40,426 | Aug 15, 2016, 06:03 PM |
| Cole G Bradley | COO | Aug 11, 2016 | Sale | $28.87 | 5,000 | 144,374 | 35,426 | Aug 15, 2016, 06:03 PM |
| BAKER FELIX | Director | Aug 15, 2016 | Buy | $27.02 | 100,000 | 2,701,590 | 11,348,958 | Aug 15, 2016, 06:02 PM |
| Vaughn James J | Chief Commercial Officer | Aug 08, 2016 | Sale | $28.74 | 3,000 | 86,221 | 29,079 | Aug 10, 2016, 07:09 PM |
| Shak Steven | Chief Scientific Officer | Jul 19, 2016 | Option Exercise | $18.89 | 5,000 | 94,450 | 332,207 | Jul 22, 2016, 04:13 PM |
| Shak Steven | Chief Scientific Officer | Jul 19, 2016 | Sale | $27.42 | 5,000 | 137,111 | 327,207 | Jul 22, 2016, 04:13 PM |
| Cole G Bradley | COO | Jul 06, 2016 | Option Exercise | $18.89 | 5,000 | 94,450 | 40,426 | Jul 08, 2016, 05:05 PM |
| Cole G Bradley | COO | Jul 06, 2016 | Sale | $26.64 | 5,000 | 133,223 | 35,426 | Jul 08, 2016, 05:05 PM |
| GRAHAM GINGER L | Director | Jul 01, 2016 | Option Exercise | $26.74 | 373 | 9,974 | 7,827 | Jul 06, 2016, 06:44 PM |
| FUCHS HENRY J | Director | Jul 01, 2016 | Option Exercise | $26.74 | 373 | 9,974 | 3,606 | Jul 06, 2016, 06:43 PM |
| Cohen Fred E | Director | Jul 01, 2016 | Option Exercise | $26.74 | 373 | 9,974 | 64,893 | Jul 06, 2016, 06:42 PM |
| BAKER FELIX | Director | Jul 01, 2016 | Option Exercise | $26.74 | 4,476 | 119,688 | 11,259,062 | Jul 06, 2016, 06:22 PM |
| Shak Steven | Chief Scientific Officer | Jun 21, 2016 | Option Exercise | $18.89 | 5,000 | 94,450 | 332,207 | Jun 23, 2016, 04:14 PM |
| Shak Steven | Chief Scientific Officer | Jun 21, 2016 | Sale | $25.77 | 5,000 | 128,859 | 327,307 | Jun 23, 2016, 04:14 PM |
| Cole G Bradley | COO | Jun 09, 2016 | Option Exercise | $18.89 | 5,000 | 94,450 | 40,426 | Jun 13, 2016, 04:13 PM |
| Cole G Bradley | COO | Jun 09, 2016 | Sale | $26.62 | 5,000 | 133,118 | 35,626 | Jun 13, 2016, 04:13 PM |
| Vaughn James J | Chief Commercial Officer | Jun 06, 2016 | Option Exercise | $18.89 | 1,997 | 37,723 | 34,076 | Jun 08, 2016, 04:49 PM |
| Vaughn James J | Chief Commercial Officer | Jun 06, 2016 | Sale | $28.00 | 1,997 | 55,916 | 32,079 | Jun 08, 2016, 04:49 PM |
| BAKER FELIX | Director | May 17, 2016 | Option Exercise | $10.73 | 49,500 | 531,135 | 11,258,316 | May 19, 2016, 06:23 PM |
| Cole G Bradley | COO | May 16, 2016 | Option Exercise | $18.89 | 5,000 | 94,450 | 39,970 | May 18, 2016, 07:34 PM |
| Cole G Bradley | COO | May 16, 2016 | Sale | $27.60 | 5,000 | 137,994 | 34,970 | May 18, 2016, 07:34 PM |
| Febbo Phillip G. | Chief Medical Officer | May 10, 2016 | Sale | $27.20 | 6,324 | 172,034 | 15,113 | May 12, 2016, 04:57 PM |
| Vaughn James J | Chief Commercial Officer | May 09, 2016 | Option Exercise | $18.89 | 2,000 | 37,780 | 33,255 | May 11, 2016, 04:42 PM |
| Vaughn James J | Chief Commercial Officer | May 09, 2016 | Sale | $28.00 | 2,000 | 56,000 | 31,255 | May 11, 2016, 04:42 PM |
| Shak Steven | Chief Scientific Officer | May 04, 2016 | Option Exercise | $18.89 | 10,000 | 188,900 | 336,383 | May 06, 2016, 06:13 PM |
| Shak Steven | Chief Scientific Officer | May 04, 2016 | Sale | $25.43 | 10,000 | 254,296 | 326,383 | May 06, 2016, 06:13 PM |
| BAKER FELIX | Director | Apr 01, 2016 | Option Exercise | $25.48 | 4,704 | 119,858 | 11,250,066 | Apr 05, 2016, 05:58 PM |
| GRAHAM GINGER L | Director | Apr 01, 2016 | Option Exercise | $25.48 | 392 | 9,988 | 7,454 | Apr 04, 2016, 09:00 PM |
| FUCHS HENRY J | Director | Apr 01, 2016 | Option Exercise | $25.48 | 392 | 9,988 | 3,233 | Apr 04, 2016, 08:59 PM |
| Cohen Fred E | Director | Apr 01, 2016 | Option Exercise | $25.48 | 392 | 9,988 | 64,520 | Apr 04, 2016, 08:58 PM |
| Vaughn James J | Chief Commercial Officer | Feb 15, 2016 | Option Exercise | $26.53 | 3,371 | 89,433 | 20,705 | Feb 17, 2016, 08:51 PM |
| Shak Steven | EVP of R&D | Feb 15, 2016 | Option Exercise | $26.53 | 2,795 | 74,151 | 318,073 | Feb 17, 2016, 08:50 PM |
| Pla Frederic | Chief Bus & Prod Dev Officer | Feb 15, 2016 | Option Exercise | $26.53 | 1,580 | 41,917 | 15,068 | Feb 17, 2016, 08:46 PM |
| McEachron Kim | Chief People Officer | Feb 15, 2016 | Option Exercise | $26.53 | 1,961 | 52,025 | 15,473 | Feb 17, 2016, 08:45 PM |
| Leber Laura | Chief Communication Officer | Feb 15, 2016 | Option Exercise | $26.53 | 2,093 | 55,527 | 10,866 | Feb 17, 2016, 08:44 PM |
| Febbo Phillip G. | Chief Medical Officer | Feb 15, 2016 | Option Exercise | $26.53 | 1,255 | 33,295 | 14,047 | Feb 17, 2016, 08:43 PM |
| Popovits Kimberly J | President and CEO | Feb 15, 2016 | Option Exercise | $26.53 | 3,195 | 84,763 | 32,496 | Feb 17, 2016, 08:20 PM |
| Cole G Bradley | COO | Feb 15, 2016 | Option Exercise | $26.53 | 3,008 | 79,802 | 24,420 | Feb 17, 2016, 08:07 PM |
| Vaughn James J | Chief Commercial Officer | Feb 09, 2016 | Option Exercise | $18.89 | 3 | 57 | 24,079 | Feb 11, 2016, 04:24 PM |
| Vaughn James J | Chief Commercial Officer | Feb 09, 2016 | Sale | $28.00 | 3 | 84 | 24,076 | Feb 11, 2016, 04:24 PM |
| LIVINGSTON RANDALL S | Director | Jan 13, 2016 | Option Exercise | $10.73 | 1,250 | 13,412 | 7,399 | Jan 15, 2016, 05:17 PM |
| LIVINGSTON RANDALL S | Director | Jan 13, 2016 | Sale | $32.14 | 1,250 | 40,175 | 6,149 | Jan 15, 2016, 05:17 PM |
| Popovits Kimberly J | President and CEO | Jan 12, 2016 | Option Exercise | $18.89 | 5,000 | 94,450 | 40,691 | Jan 14, 2016, 04:58 PM |
| Popovits Kimberly J | President and CEO | Jan 12, 2016 | Sale | $30.34 | 5,000 | 151,679 | 35,691 | Jan 14, 2016, 04:58 PM |
| Cole G Bradley | COO | Jan 12, 2016 | Option Exercise | $18.89 | 4,000 | 75,560 | 31,428 | Jan 14, 2016, 04:56 PM |
| Cole G Bradley | COO | Jan 12, 2016 | Sale | $31.69 | 4,000 | 126,771 | 30,886 | Jan 14, 2016, 04:56 PM |
| Vaughn James J | Chief Commercial Officer | Jan 07, 2016 | Option Exercise | $18.89 | 2,000 | 37,780 | 26,076 | Jan 08, 2016, 04:13 PM |
| Vaughn James J | Chief Commercial Officer | Jan 07, 2016 | Sale | $33.63 | 2,000 | 67,265 | 24,076 | Jan 08, 2016, 04:13 PM |
| BAKER FELIX | Director | Jan 01, 2016 | Option Exercise | $35.20 | 3,408 | 119,962 | 11,249,282 | Jan 05, 2016, 06:47 PM |
| FUCHS HENRY J | Director | Jan 01, 2016 | Option Exercise | $35.20 | 284 | 9,997 | 2,841 | Jan 05, 2016, 04:20 PM |
| GRAHAM GINGER L | Director | Jan 01, 2016 | Option Exercise | $35.20 | 284 | 9,997 | 7,062 | Jan 05, 2016, 04:18 PM |
| Cohen Fred E | Director | Jan 01, 2016 | Option Exercise | $35.20 | 284 | 9,997 | 64,128 | Jan 05, 2016, 04:17 PM |
| Popovits Kimberly J | President and CEO | Dec 15, 2015 | Option Exercise | $18.89 | 5,000 | 94,450 | 40,691 | Dec 17, 2015, 04:47 PM |
| Popovits Kimberly J | President and CEO | Dec 15, 2015 | Sale | $30.00 | 5,000 | 150,000 | 35,691 | Dec 17, 2015, 04:47 PM |
| Cole G Bradley | COO | Dec 08, 2015 | Option Exercise | $18.89 | 4,000 | 75,560 | 34,428 | Dec 10, 2015, 04:47 PM |
| Cole G Bradley | COO | Dec 08, 2015 | Sale | $29.26 | 4,000 | 117,030 | 30,428 | Dec 10, 2015, 04:47 PM |
| Leber Laura | Chief Communication Officer | Dec 07, 2015 | Option Exercise | $10.15 | 4,200 | 42,630 | 17,159 | Dec 09, 2015, 03:03 PM |
| Leber Laura | Chief Communication Officer | Dec 07, 2015 | Sale | $29.33 | 4,200 | 123,202 | 12,959 | Dec 09, 2015, 03:03 PM |
| Vaughn James J | Chief Commercial Officer | Dec 07, 2015 | Option Exercise | $18.89 | 2,000 | 37,780 | 26,076 | Dec 09, 2015, 03:02 PM |
| Vaughn James J | Chief Commercial Officer | Dec 07, 2015 | Sale | $29.33 | 2,000 | 58,668 | 24,076 | Dec 09, 2015, 03:02 PM |
| Cole G Bradley | COO | Nov 10, 2015 | Option Exercise | $18.89 | 4,000 | 75,560 | 34,326 | Nov 12, 2015, 04:08 PM |
| Cole G Bradley | COO | Nov 10, 2015 | Sale | $26.03 | 4,000 | 104,128 | 30,326 | Nov 12, 2015, 04:08 PM |
| BAKER FELIX | Director | Oct 01, 2015 | Option Exercise | $21.34 | 5,616 | 119,845 | 11,248,714 | Oct 05, 2015, 07:17 PM |
| GRAHAM GINGER L | Director | Oct 01, 2015 | Option Exercise | $21.34 | 468 | 9,987 | 6,778 | Oct 05, 2015, 05:04 PM |
| FUCHS HENRY J | Director | Oct 01, 2015 | Option Exercise | $21.34 | 468 | 9,987 | 2,557 | Oct 05, 2015, 05:02 PM |
| Cohen Fred E | Director | Oct 01, 2015 | Option Exercise | $21.34 | 468 | 9,987 | 63,844 | Oct 05, 2015, 05:01 PM |
| Cole G Bradley | COO | Sep 09, 2015 | Option Exercise | $9.39 | 3,664 | 34,405 | 33,990 | Sep 10, 2015, 04:38 PM |
| Cole G Bradley | COO | Sep 08, 2015 | Option Exercise | $9.39 | 6,000 | 56,340 | 36,326 | Sep 10, 2015, 04:38 PM |
| Cole G Bradley | COO | Sep 09, 2015 | Sale | $25.40 | 3,664 | 93,056 | 30,326 | Sep 10, 2015, 04:38 PM |
| Cole G Bradley | COO | Sep 08, 2015 | Sale | $25.32 | 6,000 | 151,929 | 30,326 | Sep 10, 2015, 04:38 PM |
| Cole G Bradley | COO | Jul 07, 2015 | Option Exercise | $9.39 | 4,000 | 37,560 | 34,326 | Jul 09, 2015, 07:25 PM |
| Cole G Bradley | COO | Jul 07, 2015 | Sale | $27.53 | 4,000 | 110,112 | 30,326 | Jul 09, 2015, 07:25 PM |
| BAKER FELIX | Director | Jul 01, 2015 | Option Exercise | $27.34 | 4,380 | 119,749 | 11,247,778 | Jul 06, 2015, 05:42 PM |
| GRAHAM GINGER L | Director | Jul 01, 2015 | Option Exercise | $27.34 | 365 | 9,979 | 6,310 | Jul 06, 2015, 05:06 PM |
| FUCHS HENRY J | Director | Jul 01, 2015 | Option Exercise | $27.34 | 365 | 9,979 | 2,089 | Jul 06, 2015, 05:04 PM |
| Cohen Fred E | Director | Jul 01, 2015 | Option Exercise | $27.34 | 365 | 9,979 | 63,376 | Jul 06, 2015, 05:03 PM |
| Cole G Bradley | COO | Jun 09, 2015 | Option Exercise | $9.39 | 4,000 | 37,560 | 34,326 | Jun 11, 2015, 05:34 PM |
| Cole G Bradley | COO | Jun 09, 2015 | Sale | $26.24 | 4,000 | 104,965 | 30,326 | Jun 11, 2015, 05:34 PM |
| Cole G Bradley | COO | May 12, 2015 | Option Exercise | $9.39 | 4,000 | 37,560 | 33,658 | May 14, 2015, 04:51 PM |
| Cole G Bradley | COO | May 12, 2015 | Sale | $27.54 | 4,000 | 110,157 | 31,558 | May 14, 2015, 04:51 PM |
| Popovits Kimberly J | President and CEO | Apr 13, 2015 | Option Exercise | $18.89 | 3,000 | 56,670 | 37,939 | Apr 15, 2015, 04:57 PM |
| Popovits Kimberly J | President and CEO | Apr 13, 2015 | Sale | $31.28 | 3,000 | 93,840 | 34,939 | Apr 15, 2015, 04:57 PM |
| Cole G Bradley | COO | Apr 07, 2015 | Option Exercise | $9.39 | 4,000 | 37,560 | 33,658 | Apr 09, 2015, 04:16 PM |
| Cole G Bradley | COO | Apr 07, 2015 | Sale | $30.44 | 4,000 | 121,747 | 29,658 | Apr 09, 2015, 04:16 PM |
| GRAHAM GINGER L | Director | Apr 01, 2015 | Option Exercise | $30.43 | 328 | 9,981 | 5,945 | Apr 03, 2015, 04:23 PM |
| FUCHS HENRY J | Director | Apr 01, 2015 | Option Exercise | $30.43 | 328 | 9,981 | 1,724 | Apr 03, 2015, 04:22 PM |
| Cohen Fred E | Director | Apr 01, 2015 | Option Exercise | $30.43 | 328 | 9,981 | 63,011 | Apr 03, 2015, 04:21 PM |
| BAKER FELIX | Director | Apr 01, 2015 | Option Exercise | $30.43 | 3,936 | 119,772 | 11,247,048 | Apr 02, 2015, 06:37 PM |
| Popovits Kimberly J | President and CEO | Mar 12, 2015 | Option Exercise | $18.89 | 3,000 | 56,670 | 37,939 | Mar 17, 2015, 05:50 PM |
| Popovits Kimberly J | President and CEO | Mar 12, 2015 | Sale | $31.91 | 3,000 | 95,717 | 34,939 | Mar 17, 2015, 05:50 PM |
| Cole G Bradley | COO | Mar 10, 2015 | Option Exercise | $9.39 | 4,000 | 37,560 | 33,658 | Mar 12, 2015, 04:05 PM |
| Cole G Bradley | COO | Mar 10, 2015 | Sale | $31.84 | 4,000 | 127,376 | 30,058 | Mar 12, 2015, 04:05 PM |
| Cole G Bradley | COO | Feb 15, 2015 | Option Exercise | $31.12 | 2,827 | 87,976 | 29,658 | Feb 18, 2015, 09:48 PM |
| Popovits Kimberly J | President and CEO | Feb 12, 2015 | Option Exercise | $18.89 | 3,000 | 56,670 | 39,965 | Feb 17, 2015, 07:12 PM |
| Popovits Kimberly J | President and CEO | Feb 12, 2015 | Sale | $29.86 | 3,000 | 89,566 | 36,965 | Feb 17, 2015, 07:12 PM |
| Cole G Bradley | COO | Feb 10, 2015 | Option Exercise | $9.39 | 4,000 | 37,560 | 25,645 | Feb 12, 2015, 05:30 PM |
| Cole G Bradley | COO | Feb 10, 2015 | Sale | $31.37 | 4,000 | 125,468 | 21,645 | Feb 12, 2015, 05:30 PM |
| LIVINGSTON RANDALL S | Director | Feb 02, 2015 | Option Exercise | $10.73 | 1,000 | 10,730 | 7,149 | Feb 04, 2015, 04:58 PM |
| LIVINGSTON RANDALL S | Director | Feb 02, 2015 | Sale | $31.93 | 1,000 | 31,931 | 6,149 | Feb 04, 2015, 04:58 PM |
| Popovits Kimberly J | President and CEO | Jan 12, 2015 | Option Exercise | $18.89 | 3,000 | 56,670 | 39,965 | Jan 14, 2015, 04:34 PM |
| Popovits Kimberly J | President and CEO | Jan 12, 2015 | Sale | $33.46 | 3,000 | 100,386 | 36,965 | Jan 14, 2015, 04:34 PM |
| BAKER FELIX | Director | Jan 01, 2015 | Option Exercise | $31.97 | 3,744 | 119,696 | 11,246,392 | Jan 05, 2015, 05:45 PM |
| GRAHAM GINGER L | Director | Jan 01, 2015 | Option Exercise | $31.97 | 312 | 9,975 | 5,617 | Jan 05, 2015, 04:29 PM |
| Cohen Fred E | Director | Jan 01, 2015 | Option Exercise | $31.97 | 312 | 9,975 | 62,683 | Jan 05, 2015, 04:27 PM |
| FUCHS HENRY J | Director | Jan 01, 2015 | Option Exercise | $31.97 | 312 | 9,975 | 1,396 | Jan 05, 2015, 04:26 PM |
| Popovits Kimberly J | President and CEO | Dec 11, 2014 | Option Exercise | $18.89 | 3,000 | 56,670 | 39,365 | Dec 15, 2014, 04:13 PM |
| Popovits Kimberly J | President and CEO | Dec 11, 2014 | Sale | $32.99 | 3,000 | 98,967 | 36,965 | Dec 15, 2014, 04:13 PM |
| Cole G Bradley | COO | Dec 08, 2014 | Option Exercise | $9.39 | 4,336 | 40,715 | 25,981 | Dec 09, 2014, 04:25 PM |
| Cole G Bradley | COO | Dec 08, 2014 | Sale | $32.52 | 4,336 | 141,004 | 21,645 | Dec 09, 2014, 04:25 PM |
| Popovits Kimberly J | President and CEO | Nov 12, 2014 | Option Exercise | $18.89 | 4,300 | 81,227 | 39,165 | Nov 14, 2014, 07:07 PM |
| Popovits Kimberly J | President and CEO | Nov 12, 2014 | Sale | $34.82 | 4,300 | 149,709 | 36,965 | Nov 14, 2014, 07:07 PM |
| Cole G Bradley | COO | Nov 10, 2014 | Option Exercise | $9.39 | 4,000 | 37,560 | 26,891 | Nov 12, 2014, 04:32 PM |
| Cole G Bradley | COO | Nov 10, 2014 | Sale | $35.35 | 4,000 | 141,388 | 22,891 | Nov 12, 2014, 04:32 PM |
| LIVINGSTON RANDALL S | Director | Nov 03, 2014 | Option Exercise | $10.73 | 3,000 | 32,190 | 9,149 | Nov 05, 2014, 05:01 PM |
| LIVINGSTON RANDALL S | Director | Nov 03, 2014 | Sale | $36.24 | 3,000 | 108,718 | 6,149 | Nov 05, 2014, 05:01 PM |
| Popovits Kimberly J | President and CEO | Oct 13, 2014 | Option Exercise | $18.89 | 3,000 | 56,670 | 39,965 | Oct 15, 2014, 04:22 PM |
| Popovits Kimberly J | President and CEO | Oct 13, 2014 | Sale | $30.78 | 3,000 | 92,326 | 36,965 | Oct 15, 2014, 04:22 PM |
| Cole G Bradley | COO | Oct 08, 2014 | Option Exercise | $9.39 | 4,000 | 37,560 | 26,891 | Oct 10, 2014, 04:19 PM |
| Cole G Bradley | COO | Oct 08, 2014 | Sale | $28.77 | 4,000 | 115,098 | 22,891 | Oct 10, 2014, 04:19 PM |
| BAKER FELIX | Director | Oct 01, 2014 | Option Exercise | $28.54 | 4,200 | 119,868 | 11,245,768 | Oct 03, 2014, 05:56 PM |
| GRAHAM GINGER L | Director | Oct 01, 2014 | Option Exercise | $28.54 | 350 | 9,989 | 5,305 | Oct 03, 2014, 04:30 PM |
| FUCHS HENRY J | Director | Oct 01, 2014 | Option Exercise | $28.54 | 350 | 9,989 | 1,084 | Oct 03, 2014, 04:28 PM |
| COLELLA SAMUEL D | Director | Oct 01, 2014 | Option Exercise | $28.54 | 350 | 9,989 | 5,305 | Oct 03, 2014, 04:27 PM |
| Cohen Fred E | Director | Oct 01, 2014 | Option Exercise | $28.54 | 350 | 9,989 | 62,371 | Oct 03, 2014, 04:26 PM |
| Popovits Kimberly J | President and CEO | Sep 11, 2014 | Option Exercise | $16.95 | 3,000 | 50,846 | 39,965 | Sep 15, 2014, 04:16 PM |
| Popovits Kimberly J | President and CEO | Sep 11, 2014 | Sale | $29.82 | 3,000 | 89,446 | 36,965 | Sep 15, 2014, 04:16 PM |
| Cole G Bradley | COO | Sep 08, 2014 | Option Exercise | $8.42 | 4,700 | 39,576 | 27,591 | Sep 10, 2014, 06:04 PM |
| Cole G Bradley | COO | Sep 08, 2014 | Sale | $30.09 | 4,700 | 141,429 | 22,891 | Sep 10, 2014, 06:04 PM |
| Shak Steven | EVP of R&D | Aug 13, 2014 | Option Exercise | $2.88 | 7,000 | 20,160 | 319,298 | Aug 15, 2014, 05:21 PM |
| Shak Steven | EVP of R&D | Aug 14, 2014 | Option Exercise | $2.88 | 6,348 | 18,282 | 318,646 | Aug 15, 2014, 05:21 PM |
| Shak Steven | EVP of R&D | Aug 14, 2014 | Sale | $27.49 | 6,348 | 174,498 | 312,298 | Aug 15, 2014, 05:21 PM |
| Shak Steven | EVP of R&D | Aug 13, 2014 | Sale | $27.25 | 7,000 | 190,726 | 312,298 | Aug 15, 2014, 05:21 PM |
| Popovits Kimberly J | President and CEO | Aug 12, 2014 | Option Exercise | $9.39 | 3,000 | 28,170 | 39,965 | Aug 14, 2014, 04:54 PM |
| Popovits Kimberly J | President and CEO | Aug 12, 2014 | Sale | $26.07 | 3,000 | 78,201 | 36,965 | Aug 14, 2014, 04:54 PM |
| Popovits Kimberly J | President and CEO | Jul 14, 2014 | Option Exercise | $9.39 | 3,000 | 28,170 | 39,965 | Jul 16, 2014, 04:17 PM |
| Popovits Kimberly J | President and CEO | Jul 14, 2014 | Sale | $26.59 | 3,000 | 79,777 | 36,965 | Jul 16, 2014, 04:17 PM |
| Cole G Bradley | COO | Jul 08, 2014 | Option Exercise | $2.88 | 2,300 | 6,624 | 25,191 | Jul 10, 2014, 04:19 PM |
| Cole G Bradley | COO | Jul 08, 2014 | Sale | $27.05 | 2,300 | 62,209 | 22,891 | Jul 10, 2014, 04:19 PM |
| Shak Steven | EVP of R&D | Jul 01, 2014 | Option Exercise | $2.88 | 7,000 | 20,160 | 319,298 | Jul 03, 2014, 06:04 PM |
| Shak Steven | EVP of R&D | Jul 01, 2014 | Sale | $27.00 | 7,000 | 188,970 | 312,298 | Jul 03, 2014, 06:04 PM |
| GRAHAM GINGER L | Director | Jul 01, 2014 | Option Exercise | $27.86 | 358 | 9,974 | 4,955 | Jul 03, 2014, 04:35 PM |
| FUCHS HENRY J | Director | Jul 01, 2014 | Option Exercise | $27.86 | 358 | 9,974 | 734 | Jul 03, 2014, 04:33 PM |
| COLELLA SAMUEL D | Director | Jul 01, 2014 | Option Exercise | $27.86 | 358 | 9,974 | 4,955 | Jul 03, 2014, 04:32 PM |
| Cohen Fred E | Director | Jul 01, 2014 | Option Exercise | $27.86 | 358 | 9,974 | 62,021 | Jul 03, 2014, 04:31 PM |
| BAKER FELIX | Director | Jul 01, 2014 | Option Exercise | $27.86 | 4,296 | 119,687 | 11,245,068 | Jul 03, 2014, 02:33 PM |
| Shak Steven | EVP of R&D | Jun 12, 2014 | Option Exercise | $2.88 | 7,000 | 20,160 | 319,298 | Jun 16, 2014, 06:08 PM |
| Shak Steven | EVP of R&D | Jun 12, 2014 | Sale | $26.73 | 7,000 | 187,107 | 316,398 | Jun 16, 2014, 06:08 PM |
| Popovits Kimberly J | President and CEO | Jun 12, 2014 | Option Exercise | $9.39 | 3,000 | 28,170 | 39,965 | Jun 16, 2014, 06:03 PM |
| Popovits Kimberly J | President and CEO | Jun 12, 2014 | Sale | $26.10 | 3,000 | 78,295 | 36,965 | Jun 16, 2014, 06:03 PM |
| Schorno Dean L | CFO | Jun 10, 2014 | Option Exercise | $18.03 | 4,000 | 72,140 | 28,524 | Jun 13, 2014, 08:07 PM |
| Schorno Dean L | CFO | Jun 10, 2014 | Sale | $27.62 | 4,000 | 110,487 | 24,524 | Jun 13, 2014, 08:07 PM |
| Cole G Bradley | COO | Jun 09, 2014 | Option Exercise | $2.88 | 2,337 | 6,731 | 25,228 | Jun 11, 2014, 05:48 PM |
| Cole G Bradley | COO | Jun 09, 2014 | Sale | $27.29 | 2,337 | 63,767 | 22,891 | Jun 11, 2014, 05:48 PM |
| Popovits Kimberly J | President and CEO | May 12, 2014 | Option Exercise | $9.39 | 3,000 | 28,170 | 39,255 | May 14, 2014, 04:04 PM |
| Popovits Kimberly J | President and CEO | May 12, 2014 | Sale | $26.54 | 3,000 | 79,617 | 36,646 | May 14, 2014, 04:04 PM |
| Schorno Dean L | CFO | May 09, 2014 | Option Exercise | $18.03 | 4,000 | 72,140 | 27,814 | May 13, 2014, 04:05 PM |
| Schorno Dean L | CFO | May 09, 2014 | Sale | $25.09 | 4,000 | 100,359 | 23,814 | May 13, 2014, 04:05 PM |
| Shak Steven | EVP of R&D | Apr 14, 2014 | Option Exercise | $2.88 | 7,000 | 20,160 | 318,547 | Apr 16, 2014, 04:19 PM |
| Shak Steven | EVP of R&D | Apr 14, 2014 | Sale | $26.25 | 7,000 | 183,734 | 311,588 | Apr 16, 2014, 04:19 PM |
| Cole G Bradley | COO | Apr 08, 2014 | Option Exercise | $2.88 | 3,000 | 8,640 | 25,226 | Apr 10, 2014, 04:20 PM |
| Cole G Bradley | COO | Apr 08, 2014 | Sale | $27.00 | 3,000 | 81,000 | 22,226 | Apr 10, 2014, 04:20 PM |
| BAKER FELIX | Director | Apr 01, 2014 | Option Exercise | $26.57 | 4,512 | 119,884 | 11,244,352 | Apr 03, 2014, 07:22 PM |
| FUCHS HENRY J | Director | Apr 01, 2014 | Option Exercise | $26.57 | 376 | 9,990 | 376 | Apr 03, 2014, 05:54 PM |
| GRAHAM GINGER L | Director | Apr 01, 2014 | Option Exercise | $26.57 | 376 | 9,990 | 4,597 | Apr 03, 2014, 04:00 PM |
| COLELLA SAMUEL D | Director | Apr 01, 2014 | Option Exercise | $26.57 | 376 | 9,990 | 4,597 | Apr 03, 2014, 03:59 PM |
| Cohen Fred E | Director | Apr 01, 2014 | Option Exercise | $26.57 | 376 | 9,990 | 61,663 | Apr 03, 2014, 03:57 PM |
| Shak Steven | EVP of R&D | Mar 14, 2014 | Option Exercise | $2.88 | 7,000 | 20,160 | 318,588 | Mar 18, 2014, 05:39 PM |
| Shak Steven | EVP of R&D | Mar 14, 2014 | Sale | $28.36 | 7,000 | 198,493 | 311,588 | Mar 18, 2014, 05:39 PM |
| Cole G Bradley | COO | Mar 10, 2014 | Option Exercise | $2.88 | 3,000 | 8,640 | 25,226 | Mar 12, 2014, 04:59 PM |
| Cole G Bradley | COO | Mar 10, 2014 | Sale | $27.76 | 3,000 | 83,290 | 22,226 | Mar 12, 2014, 04:59 PM |
| HIBBS KATHY L | SVP & General Counsel | Feb 15, 2014 | Option Exercise | $27.62 | 2,602 | 71,867 | 18,679 | Feb 19, 2014, 07:16 PM |
| HIBBS KATHY L | SVP & General Counsel | Feb 18, 2014 | Sale | $27.88 | 1,312 | 36,584 | 15,787 | Feb 19, 2014, 07:16 PM |
| Popovits Kimberly J | President and CEO | Feb 15, 2014 | Option Exercise | $27.62 | 3,611 | 99,736 | 38,636 | Feb 19, 2014, 07:15 PM |
| Cole G Bradley | COO | Feb 15, 2014 | Option Exercise | $27.62 | 2,563 | 70,790 | 23,817 | Feb 19, 2014, 07:14 PM |
| Schorno Dean L | CFO | Feb 15, 2014 | Option Exercise | $27.62 | 1,593 | 43,999 | 24,836 | Feb 19, 2014, 07:13 PM |
| Shak Steven | EVP of R&D | Feb 15, 2014 | Option Exercise | $27.62 | 2,055 | 56,759 | 312,971 | Feb 19, 2014, 07:11 PM |
| Shak Steven | EVP of R&D | Feb 14, 2014 | Option Exercise | $2.88 | 7,000 | 20,160 | 320,643 | Feb 19, 2014, 07:11 PM |
| Shak Steven | EVP of R&D | Feb 14, 2014 | Sale | $27.38 | 7,000 | 191,630 | 313,643 | Feb 19, 2014, 07:11 PM |
| Cole G Bradley | COO | Feb 10, 2014 | Option Exercise | $2.88 | 3,000 | 8,640 | 27,789 | Feb 12, 2014, 04:51 PM |
| Cole G Bradley | COO | Feb 10, 2014 | Sale | $27.00 | 3,000 | 81,000 | 24,789 | Feb 12, 2014, 04:51 PM |
| Shak Steven | EVP of R&D | Jan 15, 2014 | Option Exercise | $2.88 | 7,000 | 20,160 | 315,283 | Jan 17, 2014, 01:39 PM |
| Shak Steven | EVP of R&D | Jan 15, 2014 | Sale | $31.51 | 7,000 | 220,601 | 308,283 | Jan 17, 2014, 01:39 PM |
| Popovits Kimberly J | President and CEO | Jan 13, 2014 | Option Exercise | $9.39 | 2,500 | 23,475 | 29,366 | Jan 15, 2014, 10:26 AM |
| Popovits Kimberly J | President and CEO | Jan 13, 2014 | Sale | $30.00 | 2,500 | 75,000 | 26,866 | Jan 15, 2014, 10:26 AM |
| Cole G Bradley | COO | Jan 08, 2014 | Option Exercise | $2.88 | 3,000 | 8,640 | 21,369 | Jan 10, 2014, 03:50 PM |
| Cole G Bradley | COO | Jan 08, 2014 | Sale | $28.17 | 3,000 | 84,501 | 18,369 | Jan 10, 2014, 03:50 PM |
| GRAHAM GINGER L | Director | Jan 01, 2014 | Option Exercise | $29.27 | 341 | 9,981 | 4,221 | Jan 03, 2014, 07:05 PM |
| COLELLA SAMUEL D | Director | Jan 01, 2014 | Option Exercise | $29.27 | 341 | 9,981 | 4,221 | Jan 03, 2014, 07:04 PM |
| Cohen Fred E | Director | Jan 01, 2014 | Option Exercise | $29.27 | 341 | 9,981 | 61,287 | Jan 03, 2014, 07:03 PM |
| BAKER FELIX | Director | Jan 01, 2014 | Option Exercise | $29.27 | 4,092 | 119,773 | 11,243,600 | Jan 03, 2014, 05:29 PM |
| Shak Steven | EVP of R&D & CMO | Dec 16, 2013 | Option Exercise | $2.88 | 7,000 | 20,160 | 315,283 | Dec 18, 2013, 01:45 PM |
| Shak Steven | EVP of R&D & CMO | Dec 17, 2013 | Option Exercise | $2.88 | 7,000 | 20,160 | 315,283 | Dec 18, 2013, 01:45 PM |
| Shak Steven | EVP of R&D & CMO | Dec 16, 2013 | Sale | $29.91 | 7,000 | 209,350 | 308,283 | Dec 18, 2013, 01:45 PM |
| Shak Steven | EVP of R&D & CMO | Dec 17, 2013 | Sale | $29.24 | 7,000 | 204,671 | 308,283 | Dec 18, 2013, 01:45 PM |
| Popovits Kimberly J | President and CEO | Dec 12, 2013 | Option Exercise | $9.39 | 2,500 | 23,475 | 29,366 | Dec 16, 2013, 02:34 PM |
| Popovits Kimberly J | President and CEO | Dec 12, 2013 | Sale | $30.68 | 2,500 | 76,705 | 26,866 | Dec 16, 2013, 02:34 PM |
| Schorno Dean L | CFO | Dec 09, 2013 | Option Exercise | $17.23 | 3,000 | 51,690 | 24,557 | Dec 10, 2013, 04:40 PM |
| Schorno Dean L | CFO | Dec 09, 2013 | Sale | $33.25 | 3,000 | 99,761 | 23,557 | Dec 10, 2013, 04:40 PM |
| LIVINGSTON RANDALL S | Director | Dec 02, 2013 | Option Exercise | $10.73 | 1,000 | 10,730 | 7,149 | Dec 04, 2013, 05:52 PM |
| LIVINGSTON RANDALL S | Director | Dec 02, 2013 | Sale | $34.92 | 1,000 | 34,920 | 6,149 | Dec 04, 2013, 05:52 PM |
| Popovits Kimberly J | President and CEO | Nov 13, 2013 | Option Exercise | $9.39 | 2,500 | 23,475 | 29,366 | Nov 14, 2013, 05:59 PM |
| Popovits Kimberly J | President and CEO | Nov 12, 2013 | Option Exercise | $9.39 | 2,500 | 23,475 | 29,366 | Nov 14, 2013, 05:59 PM |
| Popovits Kimberly J | President and CEO | Nov 13, 2013 | Sale | $35.00 | 2,500 | 87,500 | 26,866 | Nov 14, 2013, 05:59 PM |
| Popovits Kimberly J | President and CEO | Nov 12, 2013 | Sale | $34.17 | 2,500 | 85,423 | 26,866 | Nov 14, 2013, 05:59 PM |
| Schorno Dean L | CFO | Nov 08, 2013 | Option Exercise | $17.33 | 3,000 | 51,990 | 24,436 | Nov 13, 2013, 07:45 PM |
| Schorno Dean L | CFO | Nov 08, 2013 | Sale | $33.36 | 3,000 | 100,090 | 21,436 | Nov 13, 2013, 07:45 PM |
| Cole G Bradley | COO | Nov 06, 2013 | Option Exercise | $1.33 | 2,868 | 3,814 | 21,003 | Nov 08, 2013, 08:37 PM |
| Cole G Bradley | COO | Nov 06, 2013 | Sale | $31.38 | 2,868 | 89,987 | 20,903 | Nov 08, 2013, 08:37 PM |
| Shak Steven | EVP of R&D & CMO | Oct 15, 2013 | Sale | $29.67 | 5,000 | 148,341 | 308,283 | Oct 17, 2013, 05:05 PM |
| Popovits Kimberly J | President and CEO | Oct 10, 2013 | Option Exercise | $4.79 | 2,500 | 11,978 | 29,366 | Oct 15, 2013, 06:23 PM |
| Popovits Kimberly J | President and CEO | Oct 10, 2013 | Sale | $30.00 | 2,500 | 75,000 | 26,866 | Oct 15, 2013, 06:23 PM |
| Cole G Bradley | COO | Oct 09, 2013 | Option Exercise | $1.33 | 2,500 | 3,325 | 20,635 | Oct 11, 2013, 04:50 PM |
| Cole G Bradley | COO | Oct 09, 2013 | Sale | $29.95 | 2,500 | 74,885 | 18,135 | Oct 11, 2013, 04:50 PM |
| MYERS WOODROW A JR | Director | Oct 01, 2013 | Option Exercise | $30.33 | 329 | 9,979 | 3,880 | Oct 03, 2013, 08:12 PM |
| GRAHAM GINGER L | Director | Oct 01, 2013 | Option Exercise | $30.33 | 329 | 9,979 | 3,880 | Oct 03, 2013, 08:11 PM |
| COLELLA SAMUEL D | Director | Oct 01, 2013 | Option Exercise | $30.33 | 329 | 9,979 | 3,880 | Oct 03, 2013, 08:09 PM |
| Cohen Fred E | Director | Oct 01, 2013 | Option Exercise | $30.33 | 329 | 9,979 | 60,946 | Oct 03, 2013, 08:07 PM |
| BAKER FELIX | Director | Oct 01, 2013 | Option Exercise | $30.33 | 3,948 | 119,743 | 11,242,918 | Oct 02, 2013, 05:27 PM |
| Shak Steven | EVP of R&D & CMO | Sep 18, 2013 | Sale | $33.73 | 5,000 | 168,629 | 313,283 | Sep 20, 2013, 05:38 PM |
| Popovits Kimberly J | President and CEO | Sep 12, 2013 | Option Exercise | $2.88 | 2,500 | 7,200 | 29,366 | Sep 16, 2013, 05:05 PM |
| Popovits Kimberly J | President and CEO | Sep 12, 2013 | Sale | $34.31 | 2,500 | 85,787 | 26,866 | Sep 16, 2013, 05:05 PM |
| Cole G Bradley | COO | Sep 09, 2013 | Option Exercise | $1.33 | 2,500 | 3,325 | 21,635 | Sep 11, 2013, 04:05 PM |
| Cole G Bradley | COO | Sep 09, 2013 | Sale | $32.53 | 2,500 | 81,329 | 19,135 | Sep 11, 2013, 04:05 PM |
| Schorno Dean L | CFO | Sep 06, 2013 | Option Exercise | $17.29 | 4,000 | 69,178 | 24,486 | Sep 10, 2013, 08:20 PM |
| Schorno Dean L | CFO | Sep 06, 2013 | Sale | $32.90 | 4,000 | 131,600 | 21,436 | Sep 10, 2013, 08:20 PM |
| LIVINGSTON RANDALL S | Director | Sep 03, 2013 | Option Exercise | $10.73 | 1,000 | 10,730 | 7,149 | Sep 04, 2013, 05:51 PM |
| LIVINGSTON RANDALL S | Director | Sep 03, 2013 | Sale | $31.49 | 1,000 | 31,492 | 6,149 | Sep 04, 2013, 05:51 PM |
| Shak Steven | EVP of R&D & CMO | Aug 14, 2013 | Sale | $32.98 | 5,000 | 164,905 | 318,283 | Aug 16, 2013, 07:24 PM |
| Schorno Dean L | CFO | Aug 09, 2013 | Option Exercise | $17.18 | 4,000 | 68,720 | 25,436 | Aug 15, 2013, 08:19 PM |
| Schorno Dean L | CFO | Aug 09, 2013 | Sale | $33.15 | 4,000 | 132,581 | 21,436 | Aug 15, 2013, 08:19 PM |
| Schorno Dean L | CFO | Jul 09, 2013 | Option Exercise | $17.22 | 4,000 | 68,885 | 20,734 | Aug 15, 2013, 08:17 PM |
| Schorno Dean L | CFO | Jul 09, 2013 | Sale | $33.81 | 4,000 | 135,237 | 17,836 | Aug 15, 2013, 08:17 PM |
| Popovits Kimberly J | President and CEO | Aug 12, 2013 | Option Exercise | $2.88 | 2,500 | 7,200 | 29,366 | Aug 14, 2013, 05:29 PM |
| Popovits Kimberly J | President and CEO | Aug 12, 2013 | Sale | $33.03 | 2,500 | 82,572 | 26,866 | Aug 14, 2013, 05:29 PM |
| Schorno Dean L | CFO | Aug 09, 2013 | Option Exercise | $17.18 | 4,000 | 68,720 | 25,436 | Aug 12, 2013, 08:48 PM |
| Schorno Dean L | CFO | Aug 09, 2013 | Sale | $33.15 | 4,000 | 132,581 | 21,436 | Aug 12, 2013, 08:48 PM |
| Cole G Bradley | COO | Aug 07, 2013 | Option Exercise | $1.33 | 2,500 | 3,325 | 21,635 | Aug 09, 2013, 05:16 PM |
| Cole G Bradley | COO | Aug 07, 2013 | Sale | $33.66 | 2,500 | 84,140 | 19,135 | Aug 09, 2013, 05:16 PM |
| Shak Steven | EVP of R&D & CMO | Jul 23, 2013 | Sale | $35.33 | 5,000 | 176,670 | 318,283 | Jul 26, 2013, 02:05 PM |
| Popovits Kimberly J | President and CEO | Jul 11, 2013 | Option Exercise | $2.88 | 2,900 | 8,352 | 20,766 | Jul 15, 2013, 07:57 PM |
| Popovits Kimberly J | President and CEO | Jul 12, 2013 | Option Exercise | $2.88 | 2,100 | 6,048 | 19,966 | Jul 15, 2013, 07:57 PM |
| Popovits Kimberly J | President and CEO | Jul 12, 2013 | Sale | $35.00 | 2,100 | 73,500 | 17,866 | Jul 15, 2013, 07:57 PM |
| Popovits Kimberly J | President and CEO | Jul 11, 2013 | Sale | $34.32 | 2,900 | 99,528 | 17,866 | Jul 15, 2013, 07:57 PM |
| Schorno Dean L | CFO | Jul 09, 2013 | Option Exercise | $17.33 | 4,000 | 69,320 | 21,836 | Jul 10, 2013, 07:47 PM |
| Schorno Dean L | CFO | Jul 09, 2013 | Sale | $33.81 | 4,000 | 135,237 | 17,836 | Jul 10, 2013, 07:47 PM |
| Cole G Bradley | COO | Jul 08, 2013 | Option Exercise | $1.33 | 2,500 | 3,325 | 15,635 | Jul 10, 2013, 07:45 PM |
| Cole G Bradley | COO | Jul 08, 2013 | Sale | $33.33 | 2,500 | 83,327 | 13,135 | Jul 10, 2013, 07:45 PM |
| BAKER FELIX | Director | Jul 01, 2013 | Option Exercise | $32.85 | 3,636 | 119,443 | 11,242,260 | Jul 03, 2013, 05:25 PM |
| MYERS WOODROW A JR | Director | Jul 01, 2013 | Option Exercise | $32.85 | 303 | 9,954 | 3,551 | Jul 03, 2013, 05:17 PM |
| GRAHAM GINGER L | Director | Jul 01, 2013 | Option Exercise | $32.85 | 303 | 9,954 | 3,551 | Jul 03, 2013, 05:16 PM |
| COLELLA SAMUEL D | Director | Jul 01, 2013 | Option Exercise | $32.85 | 303 | 9,954 | 3,551 | Jul 03, 2013, 05:15 PM |
| Cohen Fred E | Director | Jul 01, 2013 | Option Exercise | $32.85 | 303 | 9,954 | 60,617 | Jul 03, 2013, 05:14 PM |
| Shak Steven | EVP of R&D & CMO | Jun 18, 2013 | Sale | $33.52 | 5,000 | 167,605 | 326,783 | Jun 19, 2013, 05:32 PM |
| Popovits Kimberly J | President and CEO | Jun 12, 2013 | Option Exercise | $2.88 | 5,000 | 14,400 | 20,366 | Jun 14, 2013, 04:39 PM |
| Popovits Kimberly J | President and CEO | Jun 12, 2013 | Sale | $35.68 | 5,000 | 178,399 | 17,866 | Jun 14, 2013, 04:39 PM |
| Schorno Dean L | CFO | Jun 10, 2013 | Option Exercise | $17.33 | 4,000 | 69,320 | 21,836 | Jun 12, 2013, 08:28 PM |
| Schorno Dean L | CFO | Jun 10, 2013 | Sale | $35.88 | 4,000 | 143,525 | 17,836 | Jun 12, 2013, 08:28 PM |
| Cole G Bradley | COO | Jun 05, 2013 | Option Exercise | $1.33 | 2,500 | 3,325 | 15,635 | Jun 07, 2013, 05:34 PM |
| Cole G Bradley | COO | Jun 05, 2013 | Sale | $36.47 | 2,500 | 91,172 | 13,135 | Jun 07, 2013, 05:34 PM |
| BAKER FELIX | Director | Jun 05, 2013 | Buy | $35.81 | 23,152 | 829,189 | 1,730,777 | Jun 05, 2013, 05:23 PM |
| BAKER FELIX | Director | Jun 04, 2013 | Buy | $36.62 | 163,659 | 5,993,192 | 11,051,768 | Jun 05, 2013, 05:23 PM |
| BAKER FELIX | Director | Jun 05, 2013 | Buy | $35.81 | 194,621 | 6,970,351 | 11,241,654 | Jun 05, 2013, 05:23 PM |
| LIVINGSTON RANDALL S | Director | Jun 03, 2013 | Option Exercise | $10.73 | 1,000 | 10,730 | 7,149 | Jun 04, 2013, 07:03 PM |
| LIVINGSTON RANDALL S | Director | Jun 03, 2013 | Sale | $36.40 | 1,000 | 36,400 | 6,149 | Jun 04, 2013, 07:03 PM |
| BAKER FELIX | Director | Jun 03, 2013 | Buy | $36.69 | 13,644 | 500,556 | 1,690,226 | Jun 03, 2013, 05:40 PM |
| BAKER FELIX | Director | May 31, 2013 | Buy | $36.75 | 51,242 | 1,883,256 | 10,797,159 | Jun 03, 2013, 05:40 PM |
| BAKER FELIX | Director | Jun 03, 2013 | Buy | $36.69 | 114,697 | 4,207,877 | 10,909,066 | Jun 03, 2013, 05:40 PM |
| BAKER FELIX | Director | May 28, 2013 | Buy | $36.93 | 74,266 | 2,742,933 | 10,711,599 | May 29, 2013, 06:06 PM |
| BAKER FELIX | Director | May 29, 2013 | Buy | $36.82 | 41,954 | 1,544,813 | 10,752,532 | May 29, 2013, 06:06 PM |
| BAKER FELIX | Director | May 29, 2013 | Buy | $36.82 | 5,046 | 185,802 | 1,671,081 | May 29, 2013, 06:06 PM |
| BAKER FELIX | Director | May 24, 2013 | Buy | $36.93 | 62,517 | 2,308,909 | 10,646,920 | May 24, 2013, 05:04 PM |
| BAKER FELIX | Director | May 23, 2013 | Buy | $36.99 | 13,645 | 504,693 | 10,592,521 | May 24, 2013, 05:04 PM |
| BAKER FELIX | Director | May 23, 2013 | Buy | $36.59 | 3,255 | 119,106 | 10,579,208 | May 24, 2013, 05:04 PM |
| HIBBS KATHY L | SVP & General Counsel | May 22, 2013 | Option Exercise | $21.07 | 1,000 | 21,070 | 8,087 | May 23, 2013, 05:24 PM |
| HIBBS KATHY L | SVP & General Counsel | May 22, 2013 | Sale | $37.48 | 1,000 | 37,480 | 7,087 | May 23, 2013, 05:24 PM |
| Shak Steven | EVP of R&D & CMO | May 21, 2013 | Sale | $37.19 | 5,000 | 185,957 | 327,380 | May 22, 2013, 07:54 PM |
| LIVINGSTON RANDALL S | Director | May 15, 2013 | Option Exercise | $1.33 | 1,337 | 1,774 | 7,486 | May 17, 2013, 05:33 PM |
| LIVINGSTON RANDALL S | Director | May 15, 2013 | Sale | $35.83 | 1,337 | 47,904 | 6,149 | May 17, 2013, 05:33 PM |
| BAKER FELIX | Director | May 16, 2013 | Buy | $36.54 | 17,186 | 627,963 | 10,577,816 | May 16, 2013, 06:03 PM |
| BAKER FELIX | Director | May 16, 2013 | Buy | $36.54 | 2,120 | 77,463 | 1,649,473 | May 16, 2013, 06:03 PM |
| BAKER FELIX | Director | May 15, 2013 | Buy | $36.41 | 52,133 | 1,898,361 | 10,561,048 | May 16, 2013, 06:03 PM |
| HIBBS KATHY L | SVP & General Counsel | May 13, 2013 | Option Exercise | $21.07 | 1,250 | 26,337 | 8,337 | May 15, 2013, 06:10 PM |
| HIBBS KATHY L | SVP & General Counsel | May 13, 2013 | Sale | $34.42 | 1,250 | 43,031 | 7,087 | May 15, 2013, 06:10 PM |
| Popovits Kimberly J | President and CEO | May 13, 2013 | Option Exercise | $2.88 | 5,000 | 14,400 | 19,463 | May 15, 2013, 06:08 PM |
| Popovits Kimberly J | President and CEO | May 13, 2013 | Sale | $34.70 | 5,000 | 173,506 | 16,963 | May 15, 2013, 06:08 PM |
| BAKER FELIX | Director | May 14, 2013 | Buy | $35.53 | 27,184 | 965,899 | 10,515,769 | May 14, 2013, 06:40 PM |
| BAKER FELIX | Director | May 13, 2013 | Buy | $34.02 | 144,478 | 4,914,910 | 10,492,159 | May 14, 2013, 06:40 PM |
| BAKER FELIX | Director | May 13, 2013 | Buy | $34.56 | 68,764 | 2,376,256 | 10,351,197 | May 14, 2013, 06:40 PM |
| Schorno Dean L | CFO | May 09, 2013 | Option Exercise | $17.18 | 4,000 | 68,720 | 21,092 | May 13, 2013, 05:33 PM |
| Schorno Dean L | CFO | May 09, 2013 | Sale | $36.02 | 4,000 | 144,088 | 17,092 | May 13, 2013, 05:33 PM |
| Cole G Bradley | COO | May 08, 2013 | Option Exercise | $1.33 | 2,500 | 3,325 | 15,040 | May 09, 2013, 03:16 PM |
| Cole G Bradley | COO | May 08, 2013 | Sale | $35.99 | 2,500 | 89,964 | 12,540 | May 09, 2013, 03:16 PM |
| Popovits Kimberly J | President and CEO | Apr 23, 2013 | Option Exercise | $2.88 | 2,500 | 7,200 | 19,463 | Apr 25, 2013, 05:55 PM |
| Popovits Kimberly J | President and CEO | Apr 23, 2013 | Sale | $30.00 | 2,500 | 75,000 | 16,963 | Apr 25, 2013, 05:55 PM |
| Cole G Bradley | COO | Apr 03, 2013 | Option Exercise | $1.33 | 2,500 | 3,325 | 15,040 | Apr 05, 2013, 05:50 PM |
| Cole G Bradley | COO | Apr 03, 2013 | Sale | $27.79 | 2,500 | 69,483 | 12,540 | Apr 05, 2013, 05:50 PM |
| BAKER FELIX | Director | Apr 01, 2013 | Option Exercise | $27.99 | 4,284 | 119,909 | 10,306,953 | Apr 03, 2013, 05:50 PM |
| GRAHAM GINGER L | Director | Apr 01, 2013 | Option Exercise | $27.99 | 357 | 9,992 | 3,248 | Apr 03, 2013, 04:56 PM |
| Cohen Fred E | Director | Apr 01, 2013 | Option Exercise | $27.99 | 357 | 9,992 | 60,314 | Apr 03, 2013, 04:55 PM |
| COLELLA SAMUEL D | Director | Apr 01, 2013 | Option Exercise | $27.99 | 357 | 9,992 | 3,248 | Apr 03, 2013, 04:54 PM |
| MYERS WOODROW A JR | Director | Apr 01, 2013 | Option Exercise | $27.99 | 357 | 9,992 | 3,248 | Apr 03, 2013, 04:53 PM |
| Cole G Bradley | COO | Mar 06, 2013 | Option Exercise | $1.33 | 2,500 | 3,325 | 15,040 | Mar 08, 2013, 04:14 PM |
| Cole G Bradley | COO | Mar 06, 2013 | Sale | $28.57 | 2,500 | 71,435 | 12,540 | Mar 08, 2013, 04:14 PM |
| HIBBS KATHY L | SVP & General Counsel | Feb 20, 2013 | Sale | $28.13 | 2,716 | 76,399 | 7,087 | Feb 22, 2013, 07:50 PM |
| BAKER FELIX | Director | Feb 21, 2013 | Buy | $27.64 | 25,120 | 694,237 | 10,306,239 | Feb 21, 2013, 06:11 PM |
| BAKER FELIX | Director | Feb 21, 2013 | Buy | $27.64 | 3,080 | 85,122 | 1,614,513 | Feb 21, 2013, 06:11 PM |
| BAKER FELIX | Director | Feb 20, 2013 | Buy | $27.97 | 20,885 | 584,220 | 10,281,731 | Feb 21, 2013, 06:11 PM |
| Popovits Kimberly J | President and CEO | Feb 15, 2013 | Option Exercise | $28.77 | 2,560 | 73,651 | 18,207 | Feb 20, 2013, 07:45 PM |
| Cole G Bradley | COO | Feb 15, 2013 | Option Exercise | $28.77 | 1,819 | 52,333 | 13,239 | Feb 20, 2013, 07:33 PM |
| Shak Steven | EVP of R&D & CMO | Feb 15, 2013 | Option Exercise | $28.77 | 1,388 | 39,933 | 333,211 | Feb 20, 2013, 07:27 PM |
| Schorno Dean L | CFO | Feb 15, 2013 | Option Exercise | $28.77 | 1,141 | 32,827 | 16,799 | Feb 20, 2013, 07:22 PM |
| HIBBS KATHY L | SVP & General Counsel | Feb 15, 2013 | Option Exercise | $28.77 | 1,850 | 53,225 | 10,495 | Feb 20, 2013, 07:19 PM |
| MYERS WOODROW A JR | Director | Feb 14, 2013 | Option Exercise | $18.88 | 41,250 | 778,635 | 44,141 | Feb 15, 2013, 07:32 PM |
| MYERS WOODROW A JR | Director | Feb 14, 2013 | Sale | $28.40 | 41,250 | 1,171,529 | 2,891 | Feb 15, 2013, 07:32 PM |
| BAKER FELIX | Director | Feb 14, 2013 | Buy | $28.43 | 30,860 | 877,384 | 10,263,580 | Feb 14, 2013, 05:51 PM |
| BAKER FELIX | Director | Feb 14, 2013 | Buy | $28.43 | 3,940 | 112,019 | 1,609,152 | Feb 14, 2013, 05:51 PM |
| BAKER FELIX | Director | Feb 13, 2013 | Buy | $28.58 | 17,200 | 491,585 | 10,233,478 | Feb 14, 2013, 05:51 PM |
| BAKER FELIX | Director | Feb 11, 2013 | Buy | $28.23 | 70,929 | 2,002,446 | 10,218,600 | Feb 11, 2013, 06:43 PM |
| BAKER FELIX | Director | Feb 11, 2013 | Buy | $28.23 | 9,055 | 255,638 | 1,603,265 | Feb 11, 2013, 06:43 PM |
| BAKER FELIX | Director | Feb 08, 2013 | Buy | $27.96 | 36,376 | 1,017,106 | 10,149,413 | Feb 11, 2013, 06:43 PM |
| Cole G Bradley | COO | Feb 06, 2013 | Option Exercise | $1.33 | 2,500 | 3,325 | 16,585 | Feb 07, 2013, 05:02 PM |
| Cole G Bradley | COO | Feb 06, 2013 | Sale | $28.03 | 2,500 | 70,076 | 14,085 | Feb 07, 2013, 05:02 PM |
| LIVINGSTON RANDALL S | Director | Jan 28, 2013 | Option Exercise | $1.33 | 2,000 | 2,653 | 8,149 | Jan 29, 2013, 05:22 PM |
| LIVINGSTON RANDALL S | Director | Jan 28, 2013 | Sale | $28.77 | 2,000 | 57,543 | 6,149 | Jan 29, 2013, 05:22 PM |
| Schorno Dean L | CFO | Jan 09, 2013 | Option Exercise | $9.39 | 2,625 | 24,649 | 19,980 | Jan 11, 2013, 07:31 PM |
| Schorno Dean L | CFO | Jan 09, 2013 | Sale | $28.00 | 2,625 | 73,500 | 17,355 | Jan 11, 2013, 07:31 PM |
| Cole G Bradley | COO | Jan 09, 2013 | Option Exercise | $1.33 | 2,500 | 3,325 | 16,585 | Jan 11, 2013, 07:29 PM |
| Cole G Bradley | COO | Jan 09, 2013 | Sale | $27.88 | 2,500 | 69,694 | 14,085 | Jan 11, 2013, 07:29 PM |
| BAKER FELIX | Director | Jan 01, 2013 | Option Exercise | $27.24 | 2,202 | 59,982 | 10,117,829 | Jan 03, 2013, 08:14 PM |
| MYERS WOODROW A JR | Director | Jan 01, 2013 | Option Exercise | $27.24 | 367 | 9,997 | 2,891 | Jan 03, 2013, 05:10 PM |
| GRAHAM GINGER L | Director | Jan 01, 2013 | Option Exercise | $27.24 | 367 | 9,997 | 2,891 | Jan 03, 2013, 05:09 PM |
| COLELLA SAMUEL D | Director | Jan 01, 2013 | Option Exercise | $27.24 | 367 | 9,997 | 2,891 | Jan 03, 2013, 05:08 PM |
| Cohen Fred E | Director | Jan 01, 2013 | Option Exercise | $27.24 | 367 | 9,997 | 59,957 | Jan 03, 2013, 05:06 PM |
| Shak Steven | EVP of R&D & CMO | Dec 18, 2012 | Sale | $27.74 | 5,000 | 138,721 | 333,768 | Dec 19, 2012, 07:02 PM |
| Popovits Kimberly J | President and CEO | Dec 13, 2012 | Sale | $27.79 | 5,000 | 138,955 | 208,806 | Dec 14, 2012, 05:26 PM |
| Schorno Dean L | CFO | Dec 11, 2012 | Option Exercise | $9.39 | 3,000 | 28,170 | 20,355 | Dec 12, 2012, 05:37 PM |
| Schorno Dean L | CFO | Dec 11, 2012 | Sale | $28.00 | 3,000 | 84,000 | 17,355 | Dec 12, 2012, 05:37 PM |
| Cole G Bradley | COO | Dec 06, 2012 | Option Exercise | $1.33 | 2,500 | 3,325 | 16,585 | Dec 07, 2012, 06:50 PM |
| Cole G Bradley | COO | Dec 06, 2012 | Sale | $27.18 | 2,500 | 67,947 | 14,085 | Dec 07, 2012, 06:50 PM |
| LIVINGSTON RANDALL S | Director | Nov 26, 2012 | Option Exercise | $1.33 | 2,000 | 2,653 | 8,149 | Nov 27, 2012, 05:05 PM |
| LIVINGSTON RANDALL S | Director | Nov 26, 2012 | Sale | $27.84 | 2,000 | 55,683 | 6,149 | Nov 27, 2012, 05:05 PM |
| BAKER FELIX | Director | Nov 21, 2012 | Buy | $27.54 | 300 | 8,262 | 10,117,174 | Nov 23, 2012, 01:24 PM |
| BAKER FELIX | Director | Nov 20, 2012 | Buy | $26.83 | 229,000 | 6,143,360 | 10,116,906 | Nov 23, 2012, 01:24 PM |
| Shak Steven | EVP of R&D & CMO | Nov 20, 2012 | Sale | $26.94 | 5,000 | 134,710 | 339,067 | Nov 21, 2012, 05:36 PM |
| COLELLA SAMUEL D | Director | Nov 20, 2012 | Sale | $26.52 | 3,629 | 96,232 | 0 | Nov 20, 2012, 07:51 PM |
| COLELLA SAMUEL D | Director | Nov 20, 2012 | Sale | $26.52 | 1,871 | 49,614 | 0 | Nov 20, 2012, 07:51 PM |
| COLELLA SAMUEL D | Director | Nov 19, 2012 | Sale | $26.97 | 16,573 | 447,043 | 3,629 | Nov 20, 2012, 07:51 PM |
| COLELLA SAMUEL D | Director | Nov 19, 2012 | Sale | $26.97 | 8,543 | 230,441 | 1,871 | Nov 20, 2012, 07:51 PM |
| Popovits Kimberly J | President and CEO | Nov 14, 2012 | Sale | $27.24 | 5,000 | 136,217 | 213,406 | Nov 16, 2012, 06:20 PM |
| BAKER FELIX | Director | Nov 14, 2012 | Buy | $27.32 | 103,167 | 2,818,161 | 9,914,595 | Nov 14, 2012, 09:16 PM |
| BAKER FELIX | Director | Nov 13, 2012 | Buy | $27.99 | 103,839 | 2,906,651 | 9,822,003 | Nov 14, 2012, 09:05 PM |
| BAKER FELIX | Director | Nov 12, 2012 | Buy | $27.94 | 200,000 | 5,587,480 | 9,729,086 | Nov 14, 2012, 09:05 PM |
| BAKER FELIX | Director | Nov 09, 2012 | Buy | $27.72 | 519,933 | 14,414,195 | 9,550,108 | Nov 14, 2012, 09:05 PM |
| Schorno Dean L | CFO | Nov 12, 2012 | Option Exercise | $9.39 | 2,800 | 26,292 | 20,155 | Nov 14, 2012, 03:38 PM |
| Schorno Dean L | CFO | Nov 09, 2012 | Option Exercise | $9.39 | 200 | 1,878 | 17,555 | Nov 14, 2012, 03:38 PM |
| Schorno Dean L | CFO | Nov 09, 2012 | Sale | $28.00 | 200 | 5,600 | 17,355 | Nov 14, 2012, 03:38 PM |
| Schorno Dean L | CFO | Nov 12, 2012 | Sale | $28.00 | 2,800 | 78,400 | 17,355 | Nov 14, 2012, 03:38 PM |
| Cole G Bradley | COO | Nov 08, 2012 | Option Exercise | $1.33 | 2,500 | 3,325 | 16,585 | Nov 13, 2012, 06:43 PM |
| Cole G Bradley | COO | Nov 08, 2012 | Sale | $28.62 | 2,500 | 71,542 | 14,085 | Nov 13, 2012, 06:43 PM |
| Shak Steven | EVP of R&D & CMO | Oct 16, 2012 | Sale | $35.25 | 5,000 | 176,254 | 348,434 | Oct 18, 2012, 06:38 PM |
| Popovits Kimberly J | President and CEO | Oct 16, 2012 | Option Exercise | $23.31 | 5,000 | 116,550 | 24,523 | Oct 17, 2012, 05:59 PM |
| Popovits Kimberly J | President and CEO | Oct 16, 2012 | Sale | $35.00 | 5,000 | 175,000 | 19,523 | Oct 17, 2012, 05:59 PM |
| Popovits Kimberly J | President and CEO | Oct 15, 2012 | Sale | $31.17 | 5,000 | 155,838 | 218,406 | Oct 17, 2012, 05:59 PM |
| Schorno Dean L | CFO | Oct 12, 2012 | Option Exercise | $9.39 | 3,000 | 28,170 | 20,355 | Oct 16, 2012, 05:44 PM |
| Schorno Dean L | CFO | Oct 12, 2012 | Sale | $33.79 | 3,000 | 101,358 | 17,355 | Oct 16, 2012, 05:44 PM |
| HIBBS KATHY L | SVP & General Counsel | Oct 11, 2012 | Option Exercise | $21.07 | 1,250 | 26,337 | 12,617 | Oct 15, 2012, 05:48 PM |
| HIBBS KATHY L | SVP & General Counsel | Oct 11, 2012 | Sale | $33.78 | 1,250 | 42,224 | 11,367 | Oct 15, 2012, 05:48 PM |
| Cole G Bradley | COO | Oct 09, 2012 | Option Exercise | $1.33 | 2,500 | 3,325 | 16,585 | Oct 11, 2012, 05:51 PM |
| Cole G Bradley | COO | Oct 09, 2012 | Sale | $34.80 | 2,500 | 86,990 | 14,085 | Oct 11, 2012, 05:51 PM |
| MYERS WOODROW A JR | Director | Oct 01, 2012 | Option Exercise | $35.89 | 288 | 10,336 | 2,524 | Oct 03, 2012, 06:58 PM |
| GRAHAM GINGER L | Director | Oct 01, 2012 | Option Exercise | $35.89 | 288 | 10,336 | 2,524 | Oct 03, 2012, 06:47 PM |
| Cohen Fred E | Director | Oct 01, 2012 | Option Exercise | $35.89 | 288 | 10,336 | 59,590 | Oct 03, 2012, 06:44 PM |
| COLELLA SAMUEL D | Director | Oct 01, 2012 | Option Exercise | $35.89 | 288 | 10,336 | 2,524 | Oct 03, 2012, 06:43 PM |
| BAKER FELIX | Director | Oct 01, 2012 | Option Exercise | $35.89 | 288 | 10,336 | 288 | Oct 03, 2012, 05:59 PM |
| Shak Steven | EVP of R&D & CMO | Sep 18, 2012 | Sale | $33.76 | 5,000 | 168,800 | 348,768 | Sep 19, 2012, 05:44 PM |
| Popovits Kimberly J | President and CEO | Sep 13, 2012 | Sale | $31.69 | 5,000 | 158,450 | 223,406 | Sep 17, 2012, 07:32 PM |
| Cole G Bradley | COO | Sep 06, 2012 | Option Exercise | $1.33 | 2,500 | 3,325 | 16,585 | Sep 10, 2012, 05:43 PM |
| Cole G Bradley | COO | Sep 06, 2012 | Sale | $35.01 | 2,500 | 87,514 | 14,085 | Sep 10, 2012, 05:43 PM |
| Cohen Fred E | Director | Aug 01, 2012 | Option Exercise | $10.73 | 8,250 | 88,522 | 59,302 | Aug 31, 2012, 05:38 PM |
| MYERS WOODROW A JR | Director | Aug 21, 2012 | Option Exercise | $9.95 | 10,993 | 109,380 | 13,229 | Aug 22, 2012, 06:31 PM |
| MYERS WOODROW A JR | Director | Aug 20, 2012 | Option Exercise | $9.95 | 5,507 | 54,795 | 7,743 | Aug 22, 2012, 06:31 PM |
| MYERS WOODROW A JR | Director | Aug 21, 2012 | Sale | $35.28 | 10,993 | 387,803 | 2,236 | Aug 22, 2012, 06:31 PM |
| MYERS WOODROW A JR | Director | Aug 20, 2012 | Sale | $35.06 | 5,507 | 193,061 | 2,236 | Aug 22, 2012, 06:31 PM |
| Shak Steven | EVP of R&D & CMO | Aug 20, 2012 | Sale | $34.99 | 5,000 | 174,939 | 353,768 | Aug 22, 2012, 06:29 PM |
| Popovits Kimberly J | President and CEO | Aug 14, 2012 | Option Exercise | $23.31 | 3,103 | 72,331 | 22,626 | Aug 15, 2012, 03:12 PM |
| Popovits Kimberly J | President and CEO | Aug 13, 2012 | Option Exercise | $23.31 | 1,897 | 44,219 | 21,420 | Aug 15, 2012, 03:12 PM |
| Popovits Kimberly J | President and CEO | Aug 14, 2012 | Sale | $35.07 | 3,103 | 108,814 | 19,523 | Aug 15, 2012, 03:12 PM |
| Popovits Kimberly J | President and CEO | Aug 13, 2012 | Sale | $35.01 | 1,897 | 66,412 | 19,523 | Aug 15, 2012, 03:12 PM |
| Popovits Kimberly J | President and CEO | Aug 13, 2012 | Sale | $34.39 | 5,000 | 171,936 | 228,406 | Aug 15, 2012, 03:12 PM |
| Cole G Bradley | COO | Aug 08, 2012 | Option Exercise | $1.33 | 2,500 | 3,325 | 16,585 | Aug 09, 2012, 04:38 PM |
| Cole G Bradley | COO | Aug 08, 2012 | Sale | $30.49 | 2,500 | 76,236 | 14,085 | Aug 09, 2012, 04:38 PM |
| LIVINGSTON RANDALL S | Director | Jul 26, 2012 | Option Exercise | $1.33 | 2,000 | 2,653 | 8,149 | Jul 27, 2012, 05:51 PM |
| LIVINGSTON RANDALL S | Director | Jul 26, 2012 | Sale | $35.90 | 2,000 | 71,800 | 6,149 | Jul 27, 2012, 05:51 PM |
| Shak Steven | Chief Medical Officer | Jul 24, 2012 | Sale | $34.24 | 5,000 | 171,196 | 358,768 | Jul 25, 2012, 11:10 AM |
| Popovits Kimberly J | President and CEO | Jul 13, 2012 | Option Exercise | $23.31 | 2,100 | 48,951 | 21,623 | Jul 17, 2012, 05:57 PM |
| Popovits Kimberly J | President and CEO | Jul 13, 2012 | Sale | $35.03 | 2,100 | 73,570 | 19,523 | Jul 17, 2012, 05:57 PM |
| Popovits Kimberly J | President and CEO | Jul 13, 2012 | Sale | $34.64 | 5,000 | 173,207 | 233,406 | Jul 17, 2012, 05:57 PM |
| Scott Randal W | CEO, InVitae Corporation* | Jul 10, 2012 | Sale | $35.97 | 15,000 | 539,537 | 1,200,317 | Jul 12, 2012, 02:42 PM |
| Scott Randal W | CEO, InVitae Corporation* | Jul 11, 2012 | Sale | $34.81 | 15,000 | 522,134 | 1,185,417 | Jul 12, 2012, 02:42 PM |
| Cole G Bradley | COO | Jul 05, 2012 | Option Exercise | $1.33 | 2,500 | 3,325 | 16,585 | Jul 06, 2012, 02:16 PM |
| Cole G Bradley | COO | Jul 05, 2012 | Sale | $35.95 | 2,500 | 89,864 | 14,085 | Jul 06, 2012, 02:16 PM |
| COLELLA SAMUEL D | Director | Jul 01, 2012 | Option Exercise | $33.40 | 299 | 9,987 | 2,236 | Jul 03, 2012, 07:27 PM |
| Cohen Fred E | Director | Jul 01, 2012 | Option Exercise | $33.40 | 299 | 9,987 | 51,052 | Jul 03, 2012, 07:23 PM |
| GRAHAM GINGER L | Director | Jul 01, 2012 | Option Exercise | $33.40 | 299 | 9,987 | 2,236 | Jul 03, 2012, 07:21 PM |
| MYERS WOODROW A JR | Director | Jul 01, 2012 | Option Exercise | $33.40 | 299 | 9,987 | 2,236 | Jul 03, 2012, 07:01 PM |
| Shak Steven | Chief Medical Officer | Jun 25, 2012 | Sale | $33.25 | 5,000 | 166,252 | 363,768 | Jun 27, 2012, 07:05 PM |
| Popovits Kimberly J | President and CEO | Jun 13, 2012 | Sale | $33.36 | 5,000 | 166,805 | 238,406 | Jun 19, 2012, 07:50 PM |
| Popovits Kimberly J | President and CEO | May 31, 2012 | Buy | $23.11 | 919 | 21,239 | 19,523 | Jun 15, 2012, 05:27 PM |
| Popovits Kimberly J | President and CEO | Jun 13, 2012 | Sale | $33.36 | 5,000 | 166,805 | 238,406 | Jun 15, 2012, 05:27 PM |
| Scott Randal W | CEO, InVitae Corporation* | Jun 12, 2012 | Sale | $33.31 | 15,000 | 499,654 | 1,215,117 | Jun 13, 2012, 02:46 PM |
| Scott Randal W | CEO, InVitae Corporation* | Jun 11, 2012 | Sale | $33.77 | 15,000 | 506,562 | 1,230,717 | Jun 13, 2012, 02:46 PM |
| Cole G Bradley | COO | Jun 06, 2012 | Option Exercise | $1.33 | 2,500 | 3,325 | 16,007 | Jun 08, 2012, 02:39 PM |
| Cole G Bradley | COO | Jun 06, 2012 | Sale | $33.97 | 2,500 | 84,919 | 13,507 | Jun 08, 2012, 02:39 PM |
| Shak Steven | Chief Medical Officer | May 24, 2012 | Sale | $33.80 | 5,000 | 168,979 | 367,849 | May 29, 2012, 05:44 PM |
| BAKER JULIAN | Director | May 22, 2012 | Buy | $32.94 | 17,406 | 573,401 | 9,086,690 | May 23, 2012, 05:03 PM |
| BAKER JULIAN | Director | May 21, 2012 | Buy | $32.18 | 150,000 | 4,826,972 | 9,069,664 | May 23, 2012, 05:03 PM |
| COLELLA SAMUEL D | Director | May 17, 2012 | Sale | $33.52 | 5,781 | 193,794 | 13,577 | May 18, 2012, 06:21 PM |
| COLELLA SAMUEL D | Director | May 18, 2012 | Sale | $32.13 | 6,137 | 197,168 | 20,202 | May 18, 2012, 06:21 PM |
| COLELLA SAMUEL D | Director | May 18, 2012 | Sale | $32.13 | 3,163 | 101,620 | 10,414 | May 18, 2012, 06:21 PM |
| COLELLA SAMUEL D | Director | May 17, 2012 | Sale | $33.52 | 11,213 | 375,888 | 26,339 | May 18, 2012, 06:21 PM |
| Popovits Kimberly J | President and CEO | May 16, 2012 | Option Exercise | $23.31 | 5,000 | 116,550 | 250,656 | May 17, 2012, 05:39 PM |
| Popovits Kimberly J | President and CEO | May 16, 2012 | Sale | $35.00 | 5,000 | 175,000 | 245,656 | May 17, 2012, 05:39 PM |
| Popovits Kimberly J | President and CEO | May 15, 2012 | Sale | $33.46 | 5,000 | 167,292 | 245,656 | May 17, 2012, 05:39 PM |
| Schorno Dean L | CFO | May 15, 2012 | Sale | $33.69 | 1,000 | 33,686 | 17,355 | May 17, 2012, 05:35 PM |
| BAKER JULIAN | Director | May 14, 2012 | Buy | $33.68 | 212,438 | 7,153,896 | 8,762,905 | May 16, 2012, 08:18 PM |
| BAKER JULIAN | Director | May 16, 2012 | Buy | $34.46 | 23,621 | 813,925 | 8,922,942 | May 16, 2012, 08:18 PM |
| BAKER JULIAN | Director | May 15, 2012 | Buy | $34.09 | 140,000 | 4,772,474 | 8,899,838 | May 16, 2012, 08:18 PM |
| Scott Randal W | CEO, InVitae Corporation* | May 11, 2012 | Sale | $30.52 | 15,000 | 457,742 | 1,252,917 | May 14, 2012, 05:39 PM |
| Scott Randal W | CEO, InVitae Corporation* | May 10, 2012 | Sale | $29.93 | 15,000 | 448,981 | 1,260,517 | May 14, 2012, 05:39 PM |
| BAKER JULIAN | Director | May 11, 2012 | Buy | $30.22 | 26,660 | 805,567 | 8,555,121 | May 11, 2012, 06:01 PM |
| BAKER JULIAN | Director | May 10, 2012 | Buy | $29.87 | 68,681 | 2,051,783 | 8,529,088 | May 11, 2012, 06:01 PM |
| BAKER JULIAN | Director | May 09, 2012 | Buy | $29.90 | 19,547 | 584,367 | 8,462,023 | May 11, 2012, 06:01 PM |
| Cole G Bradley | COO | May 09, 2012 | Option Exercise | $1.33 | 2,500 | 3,325 | 16,007 | May 11, 2012, 12:53 PM |
| Cole G Bradley | COO | May 09, 2012 | Sale | $28.87 | 2,500 | 72,174 | 13,507 | May 11, 2012, 12:53 PM |
| BAKER JULIAN | Director | May 08, 2012 | Buy | $28.83 | 86,033 | 2,480,619 | 8,442,936 | May 08, 2012, 07:00 PM |
| BAKER JULIAN | Director | May 07, 2012 | Buy | $28.26 | 56,540 | 1,597,965 | 8,358,928 | May 08, 2012, 07:00 PM |
| BAKER JULIAN | Director | May 04, 2012 | Buy | $28.02 | 53,128 | 1,488,643 | 8,305,414 | May 08, 2012, 07:00 PM |
| LIVINGSTON RANDALL S | Director | Apr 26, 2012 | Option Exercise | $1.33 | 2,000 | 2,653 | 8,149 | Apr 27, 2012, 04:30 PM |
| LIVINGSTON RANDALL S | Director | Apr 26, 2012 | Sale | $28.21 | 2,000 | 56,429 | 6,149 | Apr 27, 2012, 04:30 PM |
| Shak Steven | Chief Medical Officer | Apr 24, 2012 | Sale | $27.93 | 5,000 | 139,630 | 372,849 | Apr 26, 2012, 09:49 AM |
| Popovits Kimberly J | President and CEO | Apr 23, 2012 | Sale | $27.79 | 5,000 | 138,964 | 250,656 | Apr 24, 2012, 05:06 PM |
| Schorno Dean L | CFO | Apr 16, 2012 | Sale | $27.98 | 1,000 | 27,980 | 18,355 | Apr 17, 2012, 04:12 PM |
| Scott Randal W | CEO, InVitae Corporation* | Apr 11, 2012 | Sale | $28.38 | 10,000 | 283,790 | 1,275,117 | Apr 12, 2012, 05:36 PM |
| Scott Randal W | CEO, InVitae Corporation* | Apr 10, 2012 | Sale | $28.81 | 10,000 | 288,081 | 1,285,948 | Apr 12, 2012, 05:36 PM |
| Cole G Bradley | COO | Apr 04, 2012 | Option Exercise | $1.33 | 2,500 | 3,325 | 16,007 | Apr 06, 2012, 01:06 PM |
| Cole G Bradley | COO | Apr 04, 2012 | Sale | $30.28 | 2,500 | 75,691 | 13,507 | Apr 06, 2012, 01:06 PM |
| MYERS WOODROW A JR | Director | Apr 01, 2012 | Option Exercise | $30.61 | 326 | 9,979 | 1,937 | Apr 03, 2012, 02:17 PM |
| GRAHAM GINGER L | Director | Apr 01, 2012 | Option Exercise | $30.61 | 326 | 9,979 | 1,937 | Apr 03, 2012, 02:16 PM |
| COLELLA SAMUEL D | Director | Apr 01, 2012 | Option Exercise | $30.61 | 326 | 9,979 | 1,937 | Apr 03, 2012, 02:14 PM |
| Cohen Fred E | Director | Apr 01, 2012 | Option Exercise | $30.61 | 326 | 9,979 | 50,753 | Apr 03, 2012, 02:13 PM |
| Popovits Kimberly J | President and CEO | Mar 22, 2012 | Sale | $30.07 | 5,000 | 150,337 | 255,656 | Mar 26, 2012, 09:09 AM |
| Shak Steven | Chief Medical Officer | Mar 22, 2012 | Sale | $30.08 | 5,000 | 150,415 | 377,849 | Mar 26, 2012, 09:08 AM |
| Shak Steven | Chief Medical Officer | Mar 22, 2012 | Sale | $30.08 | 5,000 | 150,415 | 377,849 | Mar 23, 2012, 06:45 PM |
| Popovits Kimberly J | President and CEO | Mar 22, 2012 | Sale | $30.07 | 5,000 | 150,337 | 255,656 | Mar 23, 2012, 06:41 PM |
| Schorno Dean L | CFO | Mar 15, 2012 | Sale | $31.08 | 1,000 | 31,080 | 19,355 | Mar 19, 2012, 09:08 AM |
| Scott Randal W | CEO, InVitae Corporation | Mar 13, 2012 | Sale | $31.12 | 15,000 | 466,764 | 1,295,117 | Mar 14, 2012, 01:21 PM |
| Scott Randal W | CEO, InVitae Corporation | Mar 12, 2012 | Sale | $30.98 | 15,000 | 464,681 | 1,310,117 | Mar 14, 2012, 01:21 PM |
| Baker Biotech Capital (GP), LLC | Director | Mar 08, 2012 | Buy | $30.36 | 2,162 | 65,647 | 1,484,977 | Mar 09, 2012, 06:28 PM |
| Baker Biotech Capital (GP), LLC | Director | Mar 07, 2012 | Buy | $29.88 | 2,346 | 70,097 | 1,482,815 | Mar 09, 2012, 06:28 PM |
| 14159 capital (GP), LLC | Director | Mar 08, 2012 | Buy | $30.36 | 516 | 15,668 | 227,840 | Mar 09, 2012, 06:28 PM |
| 14159 capital (GP), LLC | Director | Mar 07, 2012 | Buy | $29.88 | 583 | 17,420 | 227,324 | Mar 09, 2012, 06:28 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Mar 08, 2012 | Buy | $30.36 | 19,513 | 592,489 | 8,255,421 | Mar 09, 2012, 06:27 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Mar 07, 2012 | Buy | $29.88 | 22,071 | 659,464 | 8,235,908 | Mar 09, 2012, 06:27 PM |
| Cole G Bradley | COO | Mar 08, 2012 | Option Exercise | $1.33 | 2,500 | 3,325 | 16,007 | Mar 09, 2012, 05:28 PM |
| Cole G Bradley | COO | Mar 08, 2012 | Sale | $29.94 | 2,500 | 74,850 | 13,507 | Mar 09, 2012, 05:28 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Mar 05, 2012 | Buy | $30.01 | 155,014 | 4,651,479 | 8,213,837 | Mar 05, 2012, 06:28 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Mar 02, 2012 | Buy | $29.52 | 91,459 | 2,699,915 | 8,058,823 | Mar 05, 2012, 06:28 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Mar 01, 2012 | Buy | $29.47 | 15,288 | 450,543 | 7,967,364 | Mar 05, 2012, 06:28 PM |
| 14159 capital (GP), LLC | Director | Mar 05, 2012 | Buy | $30.01 | 4,099 | 122,998 | 226,741 | Mar 05, 2012, 06:27 PM |
| 14159 capital (GP), LLC | Director | Mar 02, 2012 | Buy | $29.52 | 2,419 | 71,410 | 222,642 | Mar 05, 2012, 06:27 PM |
| 14159 capital (GP), LLC | Director | Mar 01, 2012 | Buy | $29.47 | 405 | 11,936 | 220,223 | Mar 05, 2012, 06:27 PM |
| Baker Biotech Capital (GP), LLC | Director | Mar 05, 2012 | Buy | $30.01 | 18,597 | 558,037 | 1,480,469 | Mar 05, 2012, 06:26 PM |
| Baker Biotech Capital (GP), LLC | Director | Mar 02, 2012 | Buy | $29.52 | 10,972 | 323,899 | 1,461,872 | Mar 05, 2012, 06:26 PM |
| Baker Biotech Capital (GP), LLC | Director | Mar 01, 2012 | Buy | $29.47 | 1,763 | 51,956 | 1,450,900 | Mar 05, 2012, 06:26 PM |
| 14159 capital (GP), LLC | Director | Feb 29, 2012 | Buy | $29.06 | 4,149 | 120,562 | 219,818 | Feb 29, 2012, 05:42 PM |
| 14159 capital (GP), LLC | Director | Feb 28, 2012 | Buy | $29.11 | 1,353 | 39,384 | 215,669 | Feb 29, 2012, 05:42 PM |
| 14159 capital (GP), LLC | Director | Feb 27, 2012 | Buy | $29.03 | 974 | 28,276 | 214,316 | Feb 29, 2012, 05:42 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Feb 29, 2012 | Buy | $29.06 | 156,902 | 4,559,274 | 7,952,076 | Feb 29, 2012, 05:41 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Feb 28, 2012 | Buy | $29.11 | 51,248 | 1,491,752 | 7,795,174 | Feb 29, 2012, 05:41 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Feb 27, 2012 | Buy | $29.03 | 36,881 | 1,070,678 | 7,743,926 | Feb 29, 2012, 05:41 PM |
| Baker Biotech Capital (GP), LLC | Director | Feb 28, 2012 | Buy | $29.11 | 5,934 | 172,730 | 1,429,585 | Feb 29, 2012, 05:39 PM |
| Baker Biotech Capital (GP), LLC | Director | Feb 27, 2012 | Buy | $29.03 | 4,270 | 123,961 | 1,423,651 | Feb 29, 2012, 05:39 PM |
| Baker Biotech Capital (GP), LLC | Director | Feb 29, 2012 | Buy | $29.06 | 19,552 | 568,144 | 1,449,137 | Feb 29, 2012, 05:39 PM |
| Popovits Kimberly J | President and CEO | Feb 24, 2012 | Sale | $28.85 | 5,000 | 144,255 | 260,656 | Feb 27, 2012, 04:34 PM |
| Popovits Kimberly J | President and CEO | Feb 23, 2012 | Sale | $28.15 | 5,000 | 140,740 | 265,656 | Feb 27, 2012, 04:34 PM |
| Shak Steven | Chief Medical Officer | Feb 23, 2012 | Sale | $28.14 | 5,000 | 140,723 | 382,849 | Feb 27, 2012, 04:33 PM |
| Schorno Dean L | CFO | Feb 15, 2012 | Option Exercise | $28.97 | 545 | 15,789 | 20,355 | Feb 24, 2012, 06:05 PM |
| Schorno Dean L | CFO | Feb 15, 2012 | Sale | $28.76 | 1,000 | 28,760 | 20,900 | Feb 24, 2012, 06:05 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Feb 23, 2012 | Buy | $28.12 | 62,098 | 1,746,432 | 7,707,045 | Feb 23, 2012, 06:11 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Feb 22, 2012 | Buy | $27.98 | 5,511 | 154,204 | 7,644,947 | Feb 23, 2012, 06:11 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Feb 21, 2012 | Buy | $27.98 | 46,909 | 1,312,368 | 7,639,436 | Feb 23, 2012, 06:11 PM |
| 14159 capital (GP), LLC | Director | Feb 23, 2012 | Buy | $28.12 | 1,639 | 46,095 | 213,342 | Feb 23, 2012, 06:08 PM |
| 14159 capital (GP), LLC | Director | Feb 22, 2012 | Buy | $27.98 | 145 | 4,057 | 211,703 | Feb 23, 2012, 06:08 PM |
| 14159 capital (GP), LLC | Director | Feb 21, 2012 | Buy | $27.98 | 1,238 | 34,635 | 211,558 | Feb 23, 2012, 06:08 PM |
| Baker Biotech Capital (GP), LLC | Director | Feb 23, 2012 | Buy | $28.12 | 7,477 | 210,282 | 1,419,381 | Feb 23, 2012, 06:08 PM |
| Baker Biotech Capital (GP), LLC | Director | Feb 22, 2012 | Buy | $27.98 | 638 | 17,852 | 1,411,904 | Feb 23, 2012, 06:08 PM |
| Baker Biotech Capital (GP), LLC | Director | Feb 21, 2012 | Buy | $27.98 | 5,217 | 145,955 | 1,411,266 | Feb 23, 2012, 06:08 PM |
| Shak Steven | Chief Medical Officer | Feb 15, 2012 | Option Exercise | $28.97 | 629 | 18,222 | 387,849 | Feb 17, 2012, 08:08 PM |
| Scott Randal W | Executive Chairman | Feb 15, 2012 | Option Exercise | $28.97 | 629 | 18,222 | 1,325,117 | Feb 17, 2012, 08:05 PM |
| Schorno Dean L | CFO | Feb 15, 2012 | Option Exercise | $28.97 | 545 | 15,789 | 20,600 | Feb 17, 2012, 08:01 PM |
| Schorno Dean L | CFO | Feb 15, 2012 | Sale | $28.76 | 755 | 21,714 | 21,145 | Feb 17, 2012, 08:01 PM |
| Popovits Kimberly J | President and CEO | Feb 15, 2012 | Option Exercise | $28.97 | 1,396 | 40,442 | 18,604 | Feb 17, 2012, 07:56 PM |
| Cole G Bradley | COO | Feb 15, 2012 | Option Exercise | $28.97 | 943 | 27,319 | 13,507 | Feb 17, 2012, 07:41 PM |
| Baker Joffre | Chief Scientific Officer | Feb 15, 2012 | Option Exercise | $28.97 | 629 | 18,222 | 132,846 | Feb 17, 2012, 07:37 PM |
| Baker Biotech Capital (GP), LLC | Director | Feb 16, 2012 | Buy | $29.73 | 21,900 | 651,092 | 1,406,049 | Feb 16, 2012, 06:58 PM |
| Baker Biotech Capital (GP), LLC | Director | Feb 15, 2012 | Buy | $28.88 | 3,944 | 113,892 | 1,384,149 | Feb 16, 2012, 06:58 PM |
| Baker Biotech Capital (GP), LLC | Director | Feb 14, 2012 | Buy | $28.44 | 7,341 | 208,756 | 1,380,205 | Feb 16, 2012, 06:58 PM |
| 14159 capital (GP), LLC | Director | Feb 16, 2012 | Buy | $29.73 | 4,889 | 145,350 | 210,320 | Feb 16, 2012, 06:58 PM |
| 14159 capital (GP), LLC | Director | Feb 15, 2012 | Buy | $28.88 | 849 | 24,517 | 205,431 | Feb 16, 2012, 06:58 PM |
| 14159 capital (GP), LLC | Director | Feb 14, 2012 | Buy | $28.44 | 1,475 | 41,945 | 204,582 | Feb 16, 2012, 06:58 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Feb 16, 2012 | Buy | $29.73 | 184,980 | 5,499,497 | 7,592,527 | Feb 16, 2012, 06:57 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Feb 15, 2012 | Buy | $28.88 | 32,125 | 927,680 | 7,407,547 | Feb 16, 2012, 06:57 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Feb 14, 2012 | Buy | $28.44 | 55,804 | 1,586,898 | 7,375,422 | Feb 16, 2012, 06:57 PM |
| Scott Randal W | Executive Chairman | Feb 10, 2012 | Sale | $26.25 | 10,000 | 262,495 | 1,325,746 | Feb 14, 2012, 07:04 PM |
| Scott Randal W | Executive Chairman | Feb 09, 2012 | Sale | $26.10 | 10,000 | 261,029 | 1,335,746 | Feb 14, 2012, 07:04 PM |
| Scott Randal W | Executive Chairman | Feb 09, 2012 | Sale | $26.10 | 10,000 | 261,029 | 1,335,746 | Feb 13, 2012, 09:25 AM |
| Scott Randal W | Executive Chairman | Feb 10, 2012 | Sale | $26.25 | 10,000 | 262,495 | 1,325,746 | Feb 13, 2012, 09:25 AM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Feb 10, 2012 | Buy | $26.59 | 159,832 | 4,249,931 | 7,319,618 | Feb 10, 2012, 09:34 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Feb 09, 2012 | Buy | $26.32 | 55,994 | 1,473,628 | 7,159,786 | Feb 10, 2012, 09:34 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Feb 08, 2012 | Buy | $26.20 | 202,089 | 5,294,563 | 7,103,792 | Feb 10, 2012, 09:34 PM |
| 14159 capital (GP), LLC | Director | Feb 10, 2012 | Buy | $26.59 | 4,225 | 112,343 | 203,107 | Feb 10, 2012, 09:33 PM |
| 14159 capital (GP), LLC | Director | Feb 09, 2012 | Buy | $26.32 | 1,478 | 38,898 | 198,882 | Feb 10, 2012, 09:33 PM |
| 14159 capital (GP), LLC | Director | Feb 08, 2012 | Buy | $26.20 | 5,340 | 139,904 | 197,404 | Feb 10, 2012, 09:33 PM |
| Baker Biotech Capital (GP), LLC | Director | Feb 10, 2012 | Buy | $26.59 | 24,582 | 653,635 | 1,372,864 | Feb 10, 2012, 09:33 PM |
| Baker Biotech Capital (GP), LLC | Director | Feb 09, 2012 | Buy | $26.32 | 8,860 | 233,174 | 1,348,282 | Feb 10, 2012, 09:33 PM |
| Baker Biotech Capital (GP), LLC | Director | Feb 08, 2012 | Buy | $26.20 | 33,141 | 868,267 | 1,339,422 | Feb 10, 2012, 09:33 PM |
| Cole G Bradley | COO | Feb 08, 2012 | Option Exercise | $1.33 | 2,500 | 3,325 | 16,950 | Feb 09, 2012, 09:16 AM |
| Cole G Bradley | COO | Feb 08, 2012 | Sale | $26.47 | 2,500 | 66,172 | 14,450 | Feb 09, 2012, 09:16 AM |
| LIVINGSTON RANDALL S | Director | Jan 26, 2012 | Option Exercise | $1.33 | 2,000 | 2,653 | 8,149 | Jan 27, 2012, 01:53 PM |
| LIVINGSTON RANDALL S | Director | Jan 26, 2012 | Sale | $27.51 | 2,000 | 55,020 | 6,149 | Jan 27, 2012, 01:53 PM |
| Popovits Kimberly J | President and CEO | Jan 25, 2012 | Sale | $26.42 | 5,000 | 132,085 | 273,292 | Jan 26, 2012, 09:19 AM |
| Popovits Kimberly J | President and CEO | Jan 24, 2012 | Sale | $26.62 | 5,000 | 133,078 | 278,292 | Jan 25, 2012, 05:27 PM |
| Shak Steven | Chief Medical Officer | Jan 24, 2012 | Sale | $26.74 | 5,000 | 133,678 | 382,778 | Jan 25, 2012, 05:24 PM |
| Schorno Dean L | CFO | Jan 17, 2012 | Sale | $28.00 | 1,000 | 27,999 | 17,900 | Jan 18, 2012, 11:44 AM |
| Cole G Bradley | COO | Jan 12, 2012 | Option Exercise | $1.33 | 2,500 | 3,325 | 10,250 | Jan 18, 2012, 11:43 AM |
| Cole G Bradley | COO | Jan 12, 2012 | Sale | $27.54 | 2,500 | 68,844 | 7,750 | Jan 18, 2012, 11:43 AM |
| Scott Randal W | Executive Chairman | Jan 11, 2012 | Sale | $27.56 | 10,000 | 275,612 | 1,341,246 | Jan 12, 2012, 01:47 PM |
| Scott Randal W | Executive Chairman | Jan 10, 2012 | Sale | $27.35 | 10,000 | 273,530 | 1,351,146 | Jan 12, 2012, 01:47 PM |
| Cohen Fred E | Director | Jan 01, 2012 | Option Exercise | $25.39 | 393 | 9,978 | 50,427 | Jan 06, 2012, 06:33 PM |
| GRAHAM GINGER L | Director | Jan 01, 2012 | Option Exercise | $25.39 | 393 | 9,978 | 1,611 | Jan 06, 2012, 06:32 PM |
| MYERS WOODROW A JR | Director | Jan 01, 2012 | Option Exercise | $25.39 | 393 | 9,978 | 1,611 | Jan 06, 2012, 06:31 PM |
| COLELLA SAMUEL D | Director | Jan 01, 2012 | Option Exercise | $25.39 | 393 | 9,978 | 1,611 | Jan 06, 2012, 06:30 PM |
| Shak Steven | Chief Medical Officer | Dec 22, 2011 | Sale | $26.03 | 5,000 | 130,156 | 387,778 | Dec 23, 2011, 10:26 AM |
| Scott Randal W | Executive Chairman | Dec 13, 2011 | Sale | $27.01 | 10,000 | 270,078 | 1,363,256 | Dec 14, 2011, 03:35 PM |
| Scott Randal W | Executive Chairman | Dec 12, 2011 | Sale | $27.57 | 10,000 | 275,652 | 1,371,246 | Dec 14, 2011, 03:35 PM |
| Cole G Bradley | COO | Dec 06, 2011 | Option Exercise | $1.33 | 2,500 | 3,325 | 10,250 | Dec 08, 2011, 12:00 PM |
| Cole G Bradley | COO | Dec 06, 2011 | Sale | $28.59 | 2,500 | 71,464 | 7,750 | Dec 08, 2011, 12:00 PM |
| 14159 capital (GP), LLC | Director | Dec 05, 2011 | Buy | $28.45 | 548 | 15,593 | 192,064 | Dec 05, 2011, 06:19 PM |
| 14159 capital (GP), LLC | Director | Dec 02, 2011 | Buy | $28.05 | 2,604 | 73,045 | 191,516 | Dec 05, 2011, 06:19 PM |
| Baker Biotech Capital (GP), LLC | Director | Dec 01, 2011 | Buy | $27.33 | 26,537 | 725,256 | 1,286,841 | Dec 05, 2011, 06:18 PM |
| Baker Biotech Capital (GP), LLC | Director | Dec 05, 2011 | Buy | $28.45 | 3,377 | 96,092 | 1,306,281 | Dec 05, 2011, 06:18 PM |
| Baker Biotech Capital (GP), LLC | Director | Dec 02, 2011 | Buy | $28.05 | 16,063 | 450,585 | 1,302,904 | Dec 05, 2011, 06:18 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Dec 05, 2011 | Buy | $28.45 | 20,456 | 582,072 | 6,901,703 | Dec 05, 2011, 06:16 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Dec 02, 2011 | Buy | $28.05 | 97,295 | 2,729,234 | 6,881,247 | Dec 05, 2011, 06:16 PM |
| 14159 capital (GP), LLC | Director | Nov 22, 2011 | Buy | $26.03 | 2,044 | 53,206 | 188,373 | Nov 23, 2011, 05:00 PM |
| 14159 capital (GP), LLC | Director | Nov 21, 2011 | Buy | $25.91 | 3,167 | 82,041 | 186,329 | Nov 23, 2011, 05:00 PM |
| 14159 capital (GP), LLC | Director | Nov 23, 2011 | Buy | $25.83 | 539 | 13,923 | 188,912 | Nov 23, 2011, 05:00 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Nov 23, 2011 | Buy | $25.83 | 67,427 | 1,741,720 | 6,783,952 | Nov 23, 2011, 04:59 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Nov 22, 2011 | Buy | $26.03 | 46,328 | 1,205,927 | 6,716,525 | Nov 23, 2011, 04:59 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Nov 21, 2011 | Buy | $25.91 | 79,984 | 2,071,986 | 6,670,197 | Nov 23, 2011, 04:59 PM |
| Baker Biotech Capital (GP), LLC | Director | Nov 23, 2011 | Buy | $25.83 | 2,273 | 58,714 | 1,260,304 | Nov 23, 2011, 04:59 PM |
| Baker Biotech Capital (GP), LLC | Director | Nov 22, 2011 | Buy | $26.03 | 1,628 | 42,377 | 1,258,031 | Nov 23, 2011, 04:59 PM |
| Baker Biotech Capital (GP), LLC | Director | Nov 21, 2011 | Buy | $25.91 | 1,630 | 42,225 | 1,256,403 | Nov 23, 2011, 04:59 PM |
| Shak Steven | Chief Medical Officer | Nov 22, 2011 | Option Exercise | $9.39 | 5,000 | 46,950 | 397,778 | Nov 23, 2011, 11:43 AM |
| Shak Steven | Chief Medical Officer | Nov 22, 2011 | Sale | $26.07 | 5,000 | 130,328 | 392,778 | Nov 23, 2011, 11:43 AM |
| Scott Randal W | Executive Chairman | Oct 11, 2011 | Sale | $22.60 | 10,000 | 225,985 | 1,431,146 | Nov 22, 2011, 07:05 PM |
| Scott Randal W | Executive Chairman | Oct 10, 2011 | Sale | $23.06 | 10,000 | 230,608 | 1,441,146 | Nov 22, 2011, 07:05 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Nov 16, 2011 | Buy | $27.35 | 24,256 | 663,310 | 6,590,213 | Nov 17, 2011, 05:35 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Nov 15, 2011 | Buy | $27.93 | 40,341 | 1,126,870 | 6,565,957 | Nov 17, 2011, 05:35 PM |
| 14159 capital (GP), LLC | Director | Nov 16, 2011 | Buy | $27.35 | 951 | 26,006 | 183,162 | Nov 17, 2011, 05:35 PM |
| 14159 capital (GP), LLC | Director | Nov 15, 2011 | Buy | $27.93 | 1,599 | 44,666 | 182,211 | Nov 17, 2011, 05:35 PM |
| Baker Biotech Capital (GP), LLC | Director | Nov 16, 2011 | Buy | $27.35 | 458 | 12,525 | 1,254,773 | Nov 17, 2011, 05:34 PM |
| 14159 capital (GP), LLC | Director | Nov 14, 2011 | Buy | $27.25 | 1,567 | 42,707 | 180,612 | Nov 14, 2011, 06:13 PM |
| 14159 capital (GP), LLC | Director | Nov 11, 2011 | Buy | $27.66 | 4,052 | 112,088 | 179,045 | Nov 14, 2011, 06:13 PM |
| 14159 capital (GP), LLC | Director | Nov 10, 2011 | Buy | $26.89 | 1,509 | 40,573 | 174,993 | Nov 14, 2011, 06:13 PM |
| 14159 capital (GP), LLC | Director | Nov 09, 2011 | Buy | $26.79 | 2,978 | 79,778 | 173,484 | Nov 14, 2011, 06:13 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Nov 09, 2011 | Buy | $26.79 | 72,479 | 1,941,654 | 6,348,720 | Nov 14, 2011, 06:13 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Nov 14, 2011 | Buy | $27.25 | 39,117 | 1,066,091 | 6,525,616 | Nov 14, 2011, 06:13 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Nov 11, 2011 | Buy | $27.66 | 100,823 | 2,789,006 | 6,486,499 | Nov 14, 2011, 06:13 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Nov 10, 2011 | Buy | $26.89 | 36,956 | 993,654 | 6,385,676 | Nov 14, 2011, 06:13 PM |
| Baker Biotech Capital (GP), LLC | Director | Nov 09, 2011 | Buy | $26.79 | 542 | 14,520 | 1,254,315 | Nov 14, 2011, 05:17 PM |
| Scott Randal W | Executive Chairman | Nov 11, 2011 | Sale | $27.53 | 10,000 | 275,280 | 1,411,146 | Nov 14, 2011, 01:28 PM |
| Scott Randal W | Executive Chairman | Nov 10, 2011 | Sale | $26.95 | 10,000 | 269,549 | 1,421,146 | Nov 14, 2011, 01:28 PM |
| Cole G Bradley | COO | Nov 08, 2011 | Option Exercise | $1.33 | 2,500 | 3,325 | 10,250 | Nov 09, 2011, 03:47 PM |
| Cole G Bradley | COO | Nov 08, 2011 | Sale | $26.60 | 2,500 | 66,506 | 7,750 | Nov 09, 2011, 03:47 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Nov 07, 2011 | Buy | $26.24 | 132,371 | 3,474,033 | 6,276,241 | Nov 07, 2011, 06:10 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Nov 04, 2011 | Buy | $25.78 | 55,920 | 1,441,461 | 6,143,870 | Nov 07, 2011, 06:10 PM |