| SBTX | | Silverback Therapeutics, Inc. | Orbimed Advisors LLC | Director | Dec 08, 2020 | Conversion | - | 7,011,765 | - | 7,519,188 | Dec 08, 2020, 08:41 PM |
| XTNT | | Xtant Medical Holdings, Inc. | Orbimed Advisors LLC | Director | Nov 17, 2020 | ATM/ITM Option Exercise | $0.01000 | 4,800,000 | 48,000 | 55,766,352 | Nov 19, 2020, 06:02 PM |
| GLTO | | Galecto, Inc. | Orbimed Advisors LLC | Director | Nov 02, 2020 | Conversion | - | 3,069,922 | - | 2,055,824 | Nov 04, 2020, 08:00 PM |
| GLTO | | Galecto, Inc. | Orbimed Advisors LLC | Director | Nov 02, 2020 | Buy | $15.00 | 733,333 | 10,999,995 | 2,579,657 | Nov 04, 2020, 08:00 PM |
| ARQT | | Arcutis Biotherapeutics, Inc. | Orbimed Advisors LLC | Director | Oct 02, 2020 | Buy | $25.00 | 496,000 | 12,400,000 | 4,267,564 | Oct 06, 2020, 05:27 PM |
| XTNT | | Xtant Medical Holdings, Inc. | Orbimed Advisors LLC | Director | Oct 01, 2020 | Award/Grant | $1.07 | 58,754,394 | 62,867,205 | 52,702,384 | Oct 05, 2020, 04:14 PM |
| PRLD | | Prelude Therapeutics Inc | Orbimed Advisors LLC | Director | Sep 25, 2020 | Buy | $19.00 | 1,236,800 | 23,499,200 | 917,412 | Sep 29, 2020, 08:10 PM |
| PRLD | | Prelude Therapeutics Inc | Orbimed Advisors LLC | Director | Sep 29, 2020 | Conversion | - | 8,332,779 | - | 9,250,191 | Sep 29, 2020, 08:10 PM |
| GRAY | | GRAYBUG VISION, INC. | Orbimed Advisors LLC | 10% Owner | Sep 25, 2020 | Buy | $16.00 | 562,500 | 9,000,000 | 562,500 | Sep 29, 2020, 04:41 PM |
| GRAY | | GRAYBUG VISION, INC. | Orbimed Advisors LLC | 10% Owner | Sep 29, 2020 | Conversion | - | 3,600,847 | - | 4,163,347 | Sep 29, 2020, 04:41 PM |
| PMVP | | PMV Pharmaceuticals, Inc. | Orbimed Advisors LLC | Director | Sep 25, 2020 | Buy | $18.00 | 950,000 | 17,100,000 | 475,000 | Sep 29, 2020, 04:39 PM |
| PMVP | | PMV Pharmaceuticals, Inc. | Orbimed Advisors LLC | Director | Sep 29, 2020 | Conversion | - | 6,114,330 | - | 6,475,291 | Sep 29, 2020, 04:39 PM |
| ETNB | | 89bio, Inc. | Orbimed Advisors LLC | Director | Sep 21, 2020 | Sale | $28.00 | 275,000 | 7,700,000 | 1,864,721 | Sep 23, 2020, 05:09 PM |
| INSP | | Inspire Medical Systems, Inc. | Orbimed Advisors LLC | Director | Aug 17, 2020 | Sale | $107.49 | 94,900 | 10,200,801 | 43,543 | Aug 19, 2020, 05:24 PM |
| INSP | | Inspire Medical Systems, Inc. | Orbimed Advisors LLC | Director | Aug 18, 2020 | Sale | $108.54 | 43,543 | 4,726,157 | 0 | Aug 19, 2020, 05:24 PM |
| INSP | | Inspire Medical Systems, Inc. | Orbimed Advisors LLC | Director | Aug 12, 2020 | Sale | $107.45 | 42,679 | 4,585,858 | 187,751 | Aug 14, 2020, 05:19 PM |
| INSP | | Inspire Medical Systems, Inc. | Orbimed Advisors LLC | Director | Aug 13, 2020 | Sale | $109.93 | 29,251 | 3,215,562 | 158,500 | Aug 14, 2020, 05:19 PM |
| INSP | | Inspire Medical Systems, Inc. | Orbimed Advisors LLC | Director | Aug 14, 2020 | Sale | $109.03 | 20,257 | 2,208,621 | 138,443 | Aug 14, 2020, 05:19 PM |
| INSP | | Inspire Medical Systems, Inc. | Orbimed Advisors LLC | Director | Aug 07, 2020 | Sale | $106.18 | 28,993 | 3,078,477 | 318,007 | Aug 11, 2020, 06:23 PM |
| INSP | | Inspire Medical Systems, Inc. | Orbimed Advisors LLC | Director | Aug 10, 2020 | Sale | $105.23 | 47,700 | 5,019,471 | 270,307 | Aug 11, 2020, 06:23 PM |
| INSP | | Inspire Medical Systems, Inc. | Orbimed Advisors LLC | Director | Aug 11, 2020 | Sale | $105.78 | 39,877 | 4,218,189 | 230,430 | Aug 11, 2020, 06:23 PM |
| RPTX | | Repare Therapeutics Inc. | Orbimed Advisors LLC | Director | Jun 23, 2020 | Buy | $20.00 | 99,200 | 1,984,000 | 99,200 | Jun 25, 2020, 05:53 PM |
| RPTX | | Repare Therapeutics Inc. | Orbimed Advisors LLC | Director | Jun 23, 2020 | Conversion | - | 2,601,325 | - | 2,601,325 | Jun 25, 2020, 05:53 PM |
| RPTX | | Repare Therapeutics Inc. | Orbimed Advisors LLC | Director | Jun 23, 2020 | Buy | $20.00 | 675,000 | 13,500,000 | 3,276,325 | Jun 25, 2020, 05:53 PM |
| SCPH | | scPharmaceuticals Inc. | Orbimed Advisors LLC | 10% Owner | May 21, 2020 | Buy | $8.65 | 1,387,283 | 11,999,997 | 4,565,948 | May 26, 2020, 04:44 PM |
| ORIC | | Oric Pharmaceuticals, Inc. | Orbimed Advisors LLC | Director | Apr 28, 2020 | Conversion | - | 2,484,467 | - | 2,765,717 | Apr 28, 2020, 05:13 PM |
| ORIC | | Oric Pharmaceuticals, Inc. | Orbimed Advisors LLC | Director | Apr 24, 2020 | Buy | $16.00 | 281,250 | 4,500,000 | 281,250 | Apr 28, 2020, 05:13 PM |
| ALEC | | Alector, Inc. | Orbimed Advisors LLC | 10% Owner | Apr 14, 2020 | Sale | $23.52 | 23,231 | 546,393 | 6,002,771 | Apr 16, 2020, 08:23 PM |
| ALEC | | Alector, Inc. | Orbimed Advisors LLC | 10% Owner | Apr 16, 2020 | Sale | $23.53 | 62,183 | 1,463,166 | 5,955,674 | Apr 16, 2020, 08:23 PM |
| KROS | | Keros Therapeutics, Inc. | Orbimed Advisors LLC | Director | Apr 13, 2020 | Conversion | - | 893,534 | - | 744,612 | Apr 13, 2020, 05:17 PM |
| KROS | | Keros Therapeutics, Inc. | Orbimed Advisors LLC | Director | Apr 13, 2020 | Buy | $16.00 | 375,200 | 6,003,200 | 1,119,812 | Apr 13, 2020, 05:17 PM |
| ALEC | | Alector, Inc. | Orbimed Advisors LLC | 10% Owner | Apr 07, 2020 | Sale | $23.10 | 9,170 | 211,827 | 6,301,147 | Apr 09, 2020, 05:30 PM |
| ALEC | | Alector, Inc. | Orbimed Advisors LLC | 10% Owner | Apr 08, 2020 | Sale | $23.65 | 82,614 | 1,953,821 | 6,238,574 | Apr 09, 2020, 05:30 PM |
| ALEC | | Alector, Inc. | Orbimed Advisors LLC | 10% Owner | Apr 09, 2020 | Sale | $23.79 | 288,101 | 6,853,923 | 6,020,366 | Apr 09, 2020, 05:30 PM |
| ALEC | | Alector, Inc. | Orbimed Advisors LLC | 10% Owner | Mar 31, 2020 | Sale | $24.50 | 250,000 | 6,125,000 | 6,308,093 | Apr 02, 2020, 05:06 PM |
| ALEC | | Alector, Inc. | Orbimed Advisors LLC | 10% Owner | Mar 25, 2020 | Sale | $24.66 | 56,411 | 1,391,095 | 6,497,448 | Mar 25, 2020, 05:54 PM |
| ALEC | | Alector, Inc. | Orbimed Advisors LLC | 10% Owner | Mar 23, 2020 | Sale | $26.05 | 14,598 | 380,278 | 6,591,410 | Mar 25, 2020, 05:54 PM |
| ALEC | | Alector, Inc. | Orbimed Advisors LLC | 10% Owner | Mar 24, 2020 | Sale | $24.45 | 67,644 | 1,653,896 | 6,540,175 | Mar 25, 2020, 05:54 PM |
| IMRA | | IMARA Inc. | Orbimed Advisors LLC | Director | Mar 12, 2020 | Buy | $16.00 | 937,500 | 15,000,000 | 937,500 | Mar 16, 2020, 05:06 PM |
| IMRA | | IMARA Inc. | Orbimed Advisors LLC | Director | Mar 16, 2020 | Conversion | - | 1,594,902 | - | 2,532,402 | Mar 16, 2020, 05:06 PM |
| INSP | | Inspire Medical Systems, Inc. | Orbimed Advisors LLC | Director | Mar 06, 2020 | Sale | $83.52 | 500,000 | 41,759,998 | 347,000 | Mar 10, 2020, 05:06 PM |
| INSP | | Inspire Medical Systems, Inc. | Orbimed Advisors LLC | Director | Mar 03, 2020 | Sale | $84.24 | 500,000 | 42,122,499 | 1,272,000 | Mar 05, 2020, 06:34 PM |
| ALEC | | Alector, Inc. | Orbimed Advisors LLC | 10% Owner | Mar 02, 2020 | Sale | $26.00 | 1,874,203 | 48,729,278 | 6,602,467 | Mar 04, 2020, 12:00 AM |
| PASG | | Passage BIO, Inc. | Orbimed Advisors LLC | 10% Owner | Feb 28, 2020 | Buy | $18.00 | 373,300 | 6,719,400 | 373,300 | Mar 03, 2020, 07:07 PM |
| PASG | | Passage BIO, Inc. | Orbimed Advisors LLC | 10% Owner | Mar 03, 2020 | Conversion | - | 5,574,023 | - | 5,947,323 | Mar 03, 2020, 07:07 PM |
| ARQT | | Arcutis Biotherapeutics, Inc. | Orbimed Advisors LLC | Director | Feb 03, 2020 | Buy | $17.00 | 558,888 | 9,501,096 | 382,388 | Feb 04, 2020, 05:30 PM |
| ARQT | | Arcutis Biotherapeutics, Inc. | Orbimed Advisors LLC | Director | Feb 04, 2020 | Conversion | - | 4,114,962 | - | 4,067,564 | Feb 04, 2020, 05:30 PM |
| ALEC | | Alector, Inc. | Orbimed Advisors LLC | 10% Owner | Jan 09, 2020 | Sale | $19.50 | 379,997 | 7,409,942 | 7,992,776 | Jan 13, 2020, 04:48 PM |
| ALEC | | Alector, Inc. | Orbimed Advisors LLC | 10% Owner | Dec 20, 2019 | Sale | $19.66 | 342,500 | 6,733,550 | 8,398,697 | Dec 26, 2019, 04:54 PM |
| ALEC | | Alector, Inc. | Orbimed Advisors LLC | 10% Owner | Dec 23, 2019 | Sale | $19.82 | 94,285 | 1,868,729 | 8,335,162 | Dec 26, 2019, 04:54 PM |
| ALEC | | Alector, Inc. | Orbimed Advisors LLC | 10% Owner | Dec 24, 2019 | Sale | $19.59 | 71,800 | 1,406,562 | 8,286,838 | Dec 26, 2019, 04:54 PM |
| ALEC | | Alector, Inc. | Orbimed Advisors LLC | 10% Owner | Dec 26, 2019 | Sale | $18.60 | 10,800 | 200,880 | 8,279,563 | Dec 26, 2019, 04:54 PM |
| ALEC | | Alector, Inc. | Orbimed Advisors LLC | 10% Owner | Dec 17, 2019 | Sale | $18.52 | 954,100 | 17,669,932 | 8,629,418 | Dec 19, 2019, 04:33 PM |
| INSP | | Inspire Medical Systems, Inc. | Orbimed Advisors LLC | Director | Nov 26, 2019 | Sale | $69.99 | 70,613 | 4,941,926 | 1,452,191 | Nov 29, 2019, 11:56 AM |
| INSP | | Inspire Medical Systems, Inc. | Orbimed Advisors LLC | Director | Nov 27, 2019 | Sale | $71.63 | 53,387 | 3,823,990 | 1,398,613 | Nov 29, 2019, 11:56 AM |
| TELA | | TELA Bio, Inc. | Orbimed Advisors LLC | 10% Owner | Nov 08, 2019 | Buy | $13.00 | 384,615 | 4,999,995 | 1,568,627 | Nov 13, 2019, 08:47 PM |
| TELA | | TELA Bio, Inc. | Orbimed Advisors LLC | 10% Owner | Nov 13, 2019 | Conversion | - | 1,458,915 | - | 3,027,542 | Nov 13, 2019, 08:47 PM |
| ETNB | | 89bio, Inc. | Orbimed Advisors LLC | Director | Nov 11, 2019 | Buy | $16.00 | 837,500 | 13,400,000 | 724,363 | Nov 13, 2019, 07:00 PM |
| ETNB | | 89bio, Inc. | Orbimed Advisors LLC | Director | Nov 13, 2019 | Conversion | - | 2,555,716 | - | 2,002,221 | Nov 13, 2019, 07:00 PM |
| ALEC | | Alector, Inc. | Orbimed Advisors LLC | 10% Owner | Aug 07, 2019 | Sale | $17.90 | 650,000 | 11,635,000 | 9,272,225 | Aug 09, 2019, 06:41 PM |
| CRVS | | Corvus Pharmaceuticals, Inc. | Orbimed Advisors LLC | Director | Aug 06, 2019 | Buy | $3.51 | 142,656 | 500,723 | 6,767,584 | Aug 08, 2019, 04:59 PM |
| CRVS | | Corvus Pharmaceuticals, Inc. | Orbimed Advisors LLC | Director | Jun 28, 2019 | Buy | $3.72 | 565,178 | 2,102,462 | 6,565,685 | Jul 01, 2019, 06:15 PM |
| CRVS | | Corvus Pharmaceuticals, Inc. | Orbimed Advisors LLC | Director | Jul 01, 2019 | Buy | $3.91 | 59,243 | 231,640 | 6,624,928 | Jul 01, 2019, 06:15 PM |
| CRVS | | Corvus Pharmaceuticals, Inc. | Orbimed Advisors LLC | Director | Jun 27, 2019 | Buy | $3.34 | 32,923 | 109,963 | 6,000,507 | Jul 01, 2019, 06:15 PM |
| NXTC | | NextCure, Inc. | Orbimed Advisors LLC | Director | May 13, 2019 | Conversion | - | 2,361,013 | - | 2,361,013 | May 13, 2019, 07:32 PM |
| NXTC | | NextCure, Inc. | Orbimed Advisors LLC | Director | May 13, 2019 | Buy | $15.00 | 350,000 | 5,250,000 | 2,711,013 | May 13, 2019, 07:32 PM |
| INSP | | Inspire Medical Systems, Inc. | Orbimed Advisors LLC | Director | Mar 07, 2019 | Sale | $55.01 | 68,218 | 3,752,672 | 1,761,956 | Mar 11, 2019, 09:30 PM |
| INSP | | Inspire Medical Systems, Inc. | Orbimed Advisors LLC | Director | Mar 08, 2019 | Sale | $57.75 | 290,231 | 16,760,840 | 1,471,725 | Mar 11, 2019, 09:30 PM |
| ALEC | | Alector, Inc. | Orbimed Advisors LLC | Director | Feb 11, 2019 | Conversion | - | 12,682,329 | - | 10,277,037 | Feb 11, 2019, 07:11 PM |
| ALEC | | Alector, Inc. | Orbimed Advisors LLC | Director | Feb 11, 2019 | Buy | $19.00 | 411,700 | 7,822,300 | 10,434,976 | Feb 11, 2019, 07:11 PM |
| INSP | | Inspire Medical Systems, Inc. | Orbimed Advisors LLC | Director | Dec 11, 2018 | Sale | $37.60 | 614,772 | 23,115,426 | 1,829,449 | Dec 13, 2018, 04:35 PM |
| SIBN | | SI-BONE, Inc. | Orbimed Advisors LLC | Director | Oct 19, 2018 | Conversion | - | 785,368 | - | 785,368 | Oct 19, 2018, 04:52 PM |
| SIBN | | SI-BONE, Inc. | Orbimed Advisors LLC | Director | Oct 19, 2018 | Buy | $15.00 | 200,000 | 3,000,000 | 985,368 | Oct 19, 2018, 04:52 PM |
| GH | | Guardant Health, Inc. | Orbimed Advisors LLC | 10% Owner | Oct 09, 2018 | Conversion | - | 1,534,464 | - | 1,525,492 | Oct 11, 2018, 04:01 PM |
| ARPO | | Aerpio Pharmaceuticals, Inc. | Orbimed Advisors LLC | Director | Jun 28, 2018 | Buy | $3.85 | 777,500 | 2,993,375 | 5,193,946 | Jul 02, 2018, 04:56 PM |
| ADAP | | Adaptimmune Therapeutics PLC | Orbimed Advisors LLC | Director | Jun 04, 2018 | Sale | $13.57 | 17,100 | 232,047 | 4,902,910 | Jun 06, 2018, 06:10 PM |
| ADAP | | Adaptimmune Therapeutics PLC | Orbimed Advisors LLC | Director | Jun 06, 2018 | Sale | $13.49 | 1,600 | 21,584 | 4,901,310 | Jun 06, 2018, 06:10 PM |
| ADAP | | Adaptimmune Therapeutics PLC | Orbimed Advisors LLC | Director | May 30, 2018 | Sale | $13.52 | 121,000 | 1,635,920 | 4,970,010 | Jun 01, 2018, 05:25 PM |
| ADAP | | Adaptimmune Therapeutics PLC | Orbimed Advisors LLC | Director | Jun 01, 2018 | Sale | $13.49 | 50,000 | 674,500 | 4,920,010 | Jun 01, 2018, 05:25 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Orbimed Advisors LLC | 10% Owner | May 22, 2018 | Sale | $30.43 | 19,580 | 595,768 | 2,751,679 | May 24, 2018, 04:13 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Orbimed Advisors LLC | 10% Owner | May 18, 2018 | Sale | $30.77 | 69,136 | 2,127,315 | 2,832,159 | May 21, 2018, 06:15 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Orbimed Advisors LLC | 10% Owner | May 21, 2018 | Sale | $31.01 | 62,500 | 1,938,125 | 2,769,659 | May 21, 2018, 06:15 PM |
| ADAP | | Adaptimmune Therapeutics PLC | Orbimed Advisors LLC | Director | May 14, 2018 | Sale | $13.50 | 10,300 | 139,050 | 5,091,010 | May 16, 2018, 05:22 PM |
| INSP | | Inspire Medical Systems, Inc. | Orbimed Advisors LLC | 10% Owner | May 07, 2018 | Conversion | - | 2,131,721 | - | 2,131,721 | May 09, 2018, 09:21 PM |
| INSP | | Inspire Medical Systems, Inc. | Orbimed Advisors LLC | 10% Owner | May 07, 2018 | Buy | $16.00 | 312,500 | 5,000,000 | 2,444,221 | May 09, 2018, 09:21 PM |
| PIRS | | PIERIS PHARMACEUTICALS, INC. | Orbimed Advisors LLC | 10% Owner | Apr 30, 2018 | Sale | $6.35 | 1,000,000 | 6,350,000 | 4,511,130 | May 02, 2018, 05:13 PM |
| ADAP | | Adaptimmune Therapeutics PLC | Orbimed Advisors LLC | Director | Mar 27, 2018 | Sale | $11.50 | 1,016,084 | 11,684,966 | 5,133,293 | Mar 29, 2018, 06:54 PM |
| ADAP | | Adaptimmune Therapeutics PLC | Orbimed Advisors LLC | Director | Mar 29, 2018 | Sale | $11.53 | 31,983 | 368,764 | 5,101,310 | Mar 29, 2018, 06:54 PM |
| CRVS | | Corvus Pharmaceuticals, Inc. | Orbimed Advisors LLC | Director | Mar 12, 2018 | Buy | $8.50 | 588,235 | 4,999,998 | 5,967,584 | Mar 14, 2018, 01:58 PM |
| GKOS | | GLAUKOS Corp | Orbimed Advisors LLC | Director | Mar 05, 2018 | Sale | $32.44 | 210,596 | 6,831,699 | 240,314 | Mar 06, 2018, 07:36 PM |
| GKOS | | GLAUKOS Corp | Orbimed Advisors LLC | Director | Mar 06, 2018 | Sale | $30.70 | 161,321 | 4,953,274 | 66,790 | Mar 06, 2018, 07:36 PM |
| GKOS | | GLAUKOS Corp | Orbimed Advisors LLC | Director | Mar 02, 2018 | Sale | $32.29 | 464,583 | 15,002,219 | 562,839 | Mar 06, 2018, 07:36 PM |
| XTNT | | Xtant Medical Holdings, Inc. | Orbimed Advisors LLC | Director | Feb 14, 2018 | Award/Grant | $7.20 | 8,031,930 | 57,829,894 | 5,287,197 | Feb 23, 2018, 06:55 PM |
| XTNT | | Xtant Medical Holdings, Inc. | Orbimed Advisors LLC | Director | Feb 14, 2018 | Buy | $7.20 | 945,819 | 6,809,897 | 5,890,884 | Feb 23, 2018, 06:55 PM |
| PIRS | | PIERIS PHARMACEUTICALS, INC. | Orbimed Advisors LLC | 10% Owner | Feb 13, 2018 | Option/RSU Exercise | $4.77 | 7,897 | 37,671 | 5,508,552 | Feb 15, 2018, 04:57 PM |
| PIRS | | PIERIS PHARMACEUTICALS, INC. | Orbimed Advisors LLC | 10% Owner | Feb 13, 2018 | Sale | $8.98 | 7,897 | 70,915 | 5,500,730 | Feb 15, 2018, 04:57 PM |
| KALA | | Kala Pharmaceuticals, Inc. | Orbimed Advisors LLC | 10% Owner | Feb 08, 2018 | Buy | $12.93 | 25,000 | 323,250 | 3,447,840 | Feb 12, 2018, 04:35 PM |
| KALA | | Kala Pharmaceuticals, Inc. | Orbimed Advisors LLC | 10% Owner | Feb 02, 2018 | Buy | $14.73 | 37,840 | 557,383 | 3,422,840 | Feb 06, 2018, 05:05 PM |
| KALA | | Kala Pharmaceuticals, Inc. | Orbimed Advisors LLC | 10% Owner | Jan 31, 2018 | Buy | $15.00 | 339,400 | 5,091,000 | 3,362,160 | Feb 02, 2018, 05:45 PM |
| KALA | | Kala Pharmaceuticals, Inc. | Orbimed Advisors LLC | 10% Owner | Feb 01, 2018 | Buy | $14.99 | 22,840 | 342,372 | 3,385,000 | Feb 02, 2018, 05:45 PM |
