| VRNA | | Verona Pharma plc | Orbimed Advisors LLC | Director | May 12, 2023 | Sale | $21.64 | 43,200 | 934,848 | 4,137,491 | May 15, 2023, 06:07 PM |
| TELA | | TELA Bio, Inc. | Orbimed Advisors LLC | 10% Owner | Apr 19, 2023 | Sale | $9.30 | 136,000 | 1,264,800 | 2,891,542 | Apr 21, 2023, 05:08 PM |
| TELA | | TELA Bio, Inc. | Orbimed Advisors LLC | 10% Owner | Apr 20, 2023 | Sale | $9.43 | 28,300 | 266,869 | 2,863,242 | Apr 21, 2023, 05:08 PM |
| TELA | | TELA Bio, Inc. | Orbimed Advisors LLC | 10% Owner | Apr 21, 2023 | Sale | $9.41 | 27,700 | 260,657 | 2,835,542 | Apr 21, 2023, 05:08 PM |
| GLTO | | Galecto, Inc. | Orbimed Advisors LLC | 10% Owner | Apr 13, 2023 | Sale | $1.82 | 13,946 | 25,382 | 2,454,775 | Apr 17, 2023, 05:28 PM |
| GLTO | | Galecto, Inc. | Orbimed Advisors LLC | 10% Owner | Apr 14, 2023 | Sale | $1.86 | 41,446 | 77,090 | 2,426,665 | Apr 17, 2023, 05:28 PM |
| GLTO | | Galecto, Inc. | Orbimed Advisors LLC | 10% Owner | Apr 17, 2023 | Sale | $1.97 | 13,089 | 25,785 | 2,417,787 | Apr 17, 2023, 05:28 PM |
| GLTO | | Galecto, Inc. | Orbimed Advisors LLC | 10% Owner | Apr 10, 2023 | Sale | $1.79 | 51,228 | 91,698 | 2,500,582 | Apr 12, 2023, 06:44 PM |
| GLTO | | Galecto, Inc. | Orbimed Advisors LLC | 10% Owner | Apr 11, 2023 | Sale | $1.82 | 13,946 | 25,382 | 2,465,837 | Apr 12, 2023, 06:44 PM |
| GLTO | | Galecto, Inc. | Orbimed Advisors LLC | 10% Owner | Apr 12, 2023 | Sale | $1.81 | 2,363 | 4,277 | 2,464,234 | Apr 12, 2023, 06:44 PM |
| GLTO | | Galecto, Inc. | Orbimed Advisors LLC | 10% Owner | Apr 05, 2023 | Sale | $2.18 | 92,965 | 202,664 | 2,516,599 | Apr 07, 2023, 04:42 PM |
| GLTO | | Galecto, Inc. | Orbimed Advisors LLC | 10% Owner | Apr 06, 2023 | Sale | $2.00 | 9,665 | 19,330 | 2,510,041 | Apr 07, 2023, 04:42 PM |
| IRON | | Disc Medicine, Inc. | Orbimed Advisors LLC | Director | Feb 15, 2023 | Buy | $23.00 | 108,696 | 2,500,008 | 1,196,825 | Feb 17, 2023, 04:43 PM |
| TERN | | Terns Pharmaceuticals, Inc. | Orbimed Advisors LLC | Director | Dec 23, 2022 | Buy | $7.25 | 137,931 | 1,000,000 | 4,882,854 | Dec 28, 2022, 05:57 PM |
| VRNA | | Verona Pharma plc | Orbimed Advisors LLC | Director | Dec 23, 2022 | Sale | $22.84 | 2,170,368 | 49,576,607 | 35,294,568 | Dec 27, 2022, 05:38 PM |
| VRNA | | Verona Pharma plc | Orbimed Advisors LLC | Director | Dec 22, 2022 | Sale | $21.77 | 3,969,496 | 86,424,246 | 36,940,592 | Dec 27, 2022, 05:38 PM |
| SCPH | | scPharmaceuticals Inc. | Orbimed Advisors LLC | 10% Owner | Nov 25, 2022 | Buy | $5.25 | 762,380 | 4,002,495 | 5,328,328 | Nov 29, 2022, 04:36 PM |
| CMPX | | Compass Therapeutics, Inc. | Orbimed Advisors LLC | Director | Nov 08, 2022 | Buy | $3.21 | 402,000 | 1,290,420 | 15,219,994 | Nov 10, 2022, 04:44 PM |
| EWTX | | Edgewise Therapeutics, Inc. | Orbimed Advisors LLC | Director | Sep 16, 2022 | Buy | $10.32 | 484,496 | 4,999,999 | 13,981,952 | Sep 16, 2022, 04:31 PM |
| TERN | | Terns Pharmaceuticals, Inc. | Orbimed Advisors LLC | Director | Aug 16, 2022 | Buy | $2.42 | 3,690,000 | 8,929,800 | 4,744,923 | Aug 18, 2022, 05:00 PM |
| ARQT | | Arcutis Biotherapeutics, Inc. | Orbimed Advisors LLC | 10% Owner | Jun 24, 2022 | Sale | $21.31 | 341,971 | 7,287,402 | 3,534,537 | Jun 28, 2022, 04:29 PM |
| IKNA | | Ikena Oncology, Inc. | Orbimed Advisors LLC | Director | Jun 22, 2022 | Buy | $3.55 | 66,806 | 237,161 | 1,912,678 | Jun 24, 2022, 05:39 PM |
| IKNA | | Ikena Oncology, Inc. | Orbimed Advisors LLC | Director | Jun 23, 2022 | Buy | $3.71 | 23,419 | 86,884 | 1,936,097 | Jun 24, 2022, 05:39 PM |
| IKNA | | Ikena Oncology, Inc. | Orbimed Advisors LLC | Director | Jun 24, 2022 | Buy | $4.96 | 162,000 | 803,975 | 2,098,097 | Jun 24, 2022, 05:39 PM |
| PMVP | | PMV Pharmaceuticals, Inc. | Orbimed Advisors LLC | 10% Owner | May 26, 2022 | Sale | $15.93 | 26,253 | 418,210 | 87,786 | May 31, 2022, 04:36 PM |
| EWTX | | Edgewise Therapeutics, Inc. | Orbimed Advisors LLC | Director | May 18, 2022 | Buy | $7.21 | 138,000 | 994,980 | 13,497,456 | May 20, 2022, 04:38 PM |
| CMPX | | Compass Therapeutics, Inc. | Orbimed Advisors LLC | Director | May 11, 2022 | Buy | $1.79 | 64,700 | 115,813 | 14,690,178 | May 13, 2022, 05:45 PM |
| CMPX | | Compass Therapeutics, Inc. | Orbimed Advisors LLC | Director | May 12, 2022 | Buy | $2.35 | 97,094 | 228,171 | 14,787,272 | May 13, 2022, 05:45 PM |
| CMPX | | Compass Therapeutics, Inc. | Orbimed Advisors LLC | Director | May 13, 2022 | Buy | $2.49 | 30,722 | 76,498 | 14,817,994 | May 13, 2022, 05:45 PM |
| CMPX | | Compass Therapeutics, Inc. | Orbimed Advisors LLC | Director | May 09, 2022 | Buy | $1.56 | 90,712 | 141,511 | 14,601,031 | May 10, 2022, 06:21 PM |
| CMPX | | Compass Therapeutics, Inc. | Orbimed Advisors LLC | Director | May 10, 2022 | Buy | $1.60 | 24,447 | 39,115 | 14,625,478 | May 10, 2022, 06:21 PM |
| CMPX | | Compass Therapeutics, Inc. | Orbimed Advisors LLC | Director | May 06, 2022 | Buy | $1.63 | 10,200 | 16,626 | 14,510,319 | May 10, 2022, 06:21 PM |
| PASG | | Passage BIO, Inc. | Orbimed Advisors LLC | 10% Owner | May 03, 2022 | Buy | $1.93 | 221,500 | 427,495 | 6,537,923 | May 05, 2022, 05:23 PM |
| PASG | | Passage BIO, Inc. | Orbimed Advisors LLC | 10% Owner | May 04, 2022 | Buy | $1.94 | 303,500 | 588,790 | 6,841,423 | May 05, 2022, 05:23 PM |
| PASG | | Passage BIO, Inc. | Orbimed Advisors LLC | 10% Owner | Jan 20, 2022 | Buy | $5.00 | 50,800 | 254,000 | 6,316,423 | May 05, 2022, 05:11 PM |
| ARQT | | Arcutis Biotherapeutics, Inc. | Orbimed Advisors LLC | 10% Owner | Apr 08, 2022 | Sale | $20.71 | 200,000 | 4,142,000 | 3,840,564 | Apr 08, 2022, 06:06 PM |
| ARQT | | Arcutis Biotherapeutics, Inc. | Orbimed Advisors LLC | 10% Owner | Apr 06, 2022 | Sale | $20.69 | 333,204 | 6,893,991 | 4,105,564 | Apr 08, 2022, 06:06 PM |
| ARQT | | Arcutis Biotherapeutics, Inc. | Orbimed Advisors LLC | 10% Owner | Apr 07, 2022 | Sale | $20.66 | 344,996 | 7,127,617 | 3,937,764 | Apr 08, 2022, 06:06 PM |
| PMVP | | PMV Pharmaceuticals, Inc. | Orbimed Advisors LLC | 10% Owner | Mar 29, 2022 | Sale | $21.52 | 365,000 | 7,854,800 | 109,500 | Mar 31, 2022, 05:30 PM |
| PMVP | | PMV Pharmaceuticals, Inc. | Orbimed Advisors LLC | 10% Owner | Mar 30, 2022 | Sale | $22.39 | 75,000 | 1,679,250 | 34,500 | Mar 31, 2022, 05:30 PM |
| PMVP | | PMV Pharmaceuticals, Inc. | Orbimed Advisors LLC | 10% Owner | Mar 31, 2022 | Sale | $21.17 | 34,500 | 730,365 | 0 | Mar 31, 2022, 05:30 PM |
| ETNB | | 89bio, Inc. | Orbimed Advisors LLC | 10% Owner | Jan 25, 2022 | Sale | $8.40 | 49,091 | 412,364 | 1,840,176 | Jan 27, 2022, 05:22 PM |
| ETNB | | 89bio, Inc. | Orbimed Advisors LLC | 10% Owner | Jan 26, 2022 | Sale | $8.38 | 21,482 | 180,019 | 1,829,436 | Jan 27, 2022, 05:22 PM |
| PASG | | Passage BIO, Inc. | Orbimed Advisors LLC | 10% Owner | Jan 20, 2022 | Buy | $5.42 | 369,100 | 2,000,522 | 6,634,723 | Jan 24, 2022, 04:44 PM |
| PASG | | Passage BIO, Inc. | Orbimed Advisors LLC | 10% Owner | Jan 18, 2022 | Buy | $5.46 | 114,700 | 626,262 | 6,222,323 | Jan 20, 2022, 06:03 PM |
| PASG | | Passage BIO, Inc. | Orbimed Advisors LLC | 10% Owner | Jan 19, 2022 | Buy | $5.11 | 43,300 | 221,263 | 6,265,623 | Jan 20, 2022, 06:03 PM |
| PASG | | Passage BIO, Inc. | Orbimed Advisors LLC | 10% Owner | Jan 14, 2022 | Buy | $5.60 | 10,300 | 57,680 | 6,107,623 | Jan 20, 2022, 06:03 PM |
| PASG | | Passage BIO, Inc. | Orbimed Advisors LLC | 10% Owner | Jan 11, 2022 | Buy | $5.53 | 8,200 | 45,346 | 5,955,523 | Jan 13, 2022, 07:37 PM |
| PASG | | Passage BIO, Inc. | Orbimed Advisors LLC | 10% Owner | Jan 12, 2022 | Buy | $5.65 | 100,000 | 565,000 | 6,055,523 | Jan 13, 2022, 07:37 PM |
| PASG | | Passage BIO, Inc. | Orbimed Advisors LLC | 10% Owner | Jan 13, 2022 | Buy | $5.52 | 41,800 | 230,736 | 6,097,323 | Jan 13, 2022, 07:37 PM |
| JANX | | Janux Therapeutics, Inc. | Orbimed Advisors LLC | Director | Dec 29, 2021 | Sale | $20.30 | 40,400 | 820,120 | 2,258,566 | Dec 30, 2021, 09:00 PM |
| JANX | | Janux Therapeutics, Inc. | Orbimed Advisors LLC | Director | Dec 21, 2021 | Sale | $19.00 | 119,400 | 2,268,600 | 2,295,266 | Dec 23, 2021, 04:13 PM |
| JANX | | Janux Therapeutics, Inc. | Orbimed Advisors LLC | Director | Dec 16, 2021 | Sale | $19.07 | 393,300 | 7,500,231 | 2,403,566 | Dec 17, 2021, 05:13 PM |
| ACET | | Adicet Bio, Inc. | Orbimed Advisors LLC | Director | Dec 10, 2021 | Award/Grant | $14.00 | 214,285 | 2,999,990 | 242,285 | Dec 14, 2021, 06:41 PM |
| CMPX | | Compass Therapeutics, Inc. | Orbimed Advisors LLC | Director | Nov 04, 2021 | Buy | $3.50 | 5,357,143 | 18,750,001 | 14,500,119 | Nov 08, 2021, 09:06 PM |
| CRVS | | Corvus Pharmaceuticals, Inc. | Orbimed Advisors LLC | Director | Sep 20, 2021 | Sale | $6.09 | 1,109,644 | 6,757,732 | 6,943,654 | Sep 22, 2021, 05:27 PM |
| RPTX | | Repare Therapeutics Inc. | Orbimed Advisors LLC | Director | Sep 07, 2021 | Sale | $33.93 | 887 | 30,096 | 3,177,041 | Sep 08, 2021, 06:18 PM |
| RPTX | | Repare Therapeutics Inc. | Orbimed Advisors LLC | Director | Sep 03, 2021 | Sale | $34.00 | 7,197 | 244,698 | 3,177,902 | Sep 08, 2021, 06:18 PM |
| RPTX | | Repare Therapeutics Inc. | Orbimed Advisors LLC | Director | Aug 31, 2021 | Sale | $33.94 | 8,472 | 287,540 | 3,213,414 | Sep 02, 2021, 08:27 PM |
| RPTX | | Repare Therapeutics Inc. | Orbimed Advisors LLC | Director | Sep 01, 2021 | Sale | $33.98 | 12,968 | 440,653 | 3,200,828 | Sep 02, 2021, 08:27 PM |
| RPTX | | Repare Therapeutics Inc. | Orbimed Advisors LLC | Director | Sep 02, 2021 | Sale | $34.24 | 16,424 | 562,358 | 3,184,887 | Sep 02, 2021, 08:27 PM |
| RPTX | | Repare Therapeutics Inc. | Orbimed Advisors LLC | Director | Aug 30, 2021 | Sale | $33.92 | 6,697 | 227,162 | 3,221,637 | Aug 30, 2021, 06:37 PM |
| RPTX | | Repare Therapeutics Inc. | Orbimed Advisors LLC | Director | Aug 26, 2021 | Sale | $34.52 | 4,283 | 147,849 | 3,235,021 | Aug 30, 2021, 06:37 PM |
| RPTX | | Repare Therapeutics Inc. | Orbimed Advisors LLC | Director | Aug 27, 2021 | Sale | $33.94 | 7,093 | 240,736 | 3,228,137 | Aug 30, 2021, 06:37 PM |
| RPTX | | Repare Therapeutics Inc. | Orbimed Advisors LLC | Director | Aug 23, 2021 | Sale | $34.06 | 7,094 | 241,622 | 3,249,972 | Aug 25, 2021, 08:43 PM |
| RPTX | | Repare Therapeutics Inc. | Orbimed Advisors LLC | Director | Aug 24, 2021 | Sale | $34.07 | 4,039 | 137,609 | 3,246,052 | Aug 25, 2021, 08:43 PM |
| RPTX | | Repare Therapeutics Inc. | Orbimed Advisors LLC | Director | Aug 25, 2021 | Sale | $34.34 | 7,082 | 243,196 | 3,239,178 | Aug 25, 2021, 08:43 PM |
| RPTX | | Repare Therapeutics Inc. | Orbimed Advisors LLC | Director | Aug 18, 2021 | Sale | $33.99 | 2,930 | 99,591 | 3,256,857 | Aug 19, 2021, 08:55 PM |
| RPTX | | Repare Therapeutics Inc. | Orbimed Advisors LLC | Director | Aug 17, 2021 | Sale | $34.12 | 17,398 | 593,620 | 3,259,439 | Aug 19, 2021, 08:55 PM |
| IMRA | | IMARA Inc. | Orbimed Advisors LLC | Director | Jul 16, 2021 | Buy | $6.00 | 1,666,666 | 9,999,996 | 4,199,068 | Jul 23, 2021, 05:30 PM |
| IMRA | | IMARA Inc. | Orbimed Advisors LLC | Director | Jul 16, 2021 | Buy | $6.00 | 1,666,666 | 9,999,996 | 1,666,666 | Jul 16, 2021, 04:27 PM |
| SYBX | | SYNLOGIC, INC. | Orbimed Advisors LLC | Director | Apr 20, 2021 | Award/Grant | $3.00 | 1,666,666 | 4,999,998 | 3,696,662 | Apr 22, 2021, 05:18 PM |
| IKNA | | Ikena Oncology, Inc. | Orbimed Advisors LLC | Director | Mar 30, 2021 | Buy | $16.00 | 423,400 | 6,774,400 | 1,845,872 | Apr 13, 2021, 06:36 PM |
| IKNA | | Ikena Oncology, Inc. | Orbimed Advisors LLC | Director | Mar 30, 2021 | Conversion | - | 7,099,797 | - | 5,429,023 | Apr 13, 2021, 06:36 PM |
| IKNA | | Ikena Oncology, Inc. | Orbimed Advisors LLC | Director | Mar 30, 2021 | Conversion | - | 7,099,797 | - | 5,083,470 | Apr 01, 2021, 06:13 PM |
| IKNA | | Ikena Oncology, Inc. | Orbimed Advisors LLC | Director | Mar 30, 2021 | Buy | $16.00 | 423,400 | 6,774,400 | 2,191,425 | Apr 01, 2021, 06:13 PM |
| EWTX | | Edgewise Therapeutics, Inc. | Orbimed Advisors LLC | Director | Mar 30, 2021 | Conversion | - | 13,002,760 | - | 13,046,956 | Mar 31, 2021, 07:10 PM |
| EWTX | | Edgewise Therapeutics, Inc. | Orbimed Advisors LLC | Director | Mar 30, 2021 | Buy | $16.00 | 359,375 | 5,750,000 | 13,359,456 | Mar 31, 2021, 07:10 PM |
| ORIC | | Oric Pharmaceuticals, Inc. | Orbimed Advisors LLC | Director | Mar 29, 2021 | Sale | $23.31 | 75,555 | 1,761,187 | 2,240,440 | Mar 31, 2021, 05:08 PM |
| ORIC | | Oric Pharmaceuticals, Inc. | Orbimed Advisors LLC | Director | Mar 30, 2021 | Sale | $23.93 | 27,869 | 666,905 | 2,212,571 | Mar 31, 2021, 05:08 PM |
| ORIC | | Oric Pharmaceuticals, Inc. | Orbimed Advisors LLC | Director | Mar 24, 2021 | Sale | $24.80 | 32,959 | 817,383 | 2,395,334 | Mar 26, 2021, 05:51 PM |
| ORIC | | Oric Pharmaceuticals, Inc. | Orbimed Advisors LLC | Director | Mar 25, 2021 | Sale | $24.70 | 51,523 | 1,272,618 | 2,343,811 | Mar 26, 2021, 05:51 PM |
| ORIC | | Oric Pharmaceuticals, Inc. | Orbimed Advisors LLC | Director | Mar 26, 2021 | Sale | $23.88 | 27,816 | 664,246 | 2,315,995 | Mar 26, 2021, 05:51 PM |
| ORIC | | Oric Pharmaceuticals, Inc. | Orbimed Advisors LLC | Director | Mar 23, 2021 | Sale | $24.32 | 3,992 | 97,085 | 2,428,293 | Mar 23, 2021, 05:22 PM |
| ORIC | | Oric Pharmaceuticals, Inc. | Orbimed Advisors LLC | Director | Mar 19, 2021 | Sale | $26.47 | 21,275 | 563,149 | 2,439,958 | Mar 23, 2021, 05:22 PM |
| ORIC | | Oric Pharmaceuticals, Inc. | Orbimed Advisors LLC | Director | Mar 22, 2021 | Sale | $26.47 | 7,673 | 203,104 | 2,432,285 | Mar 23, 2021, 05:22 PM |
| ORIC | | Oric Pharmaceuticals, Inc. | Orbimed Advisors LLC | Director | Mar 17, 2021 | Sale | $28.43 | 18,790 | 534,200 | 2,467,292 | Mar 18, 2021, 09:07 PM |
| ORIC | | Oric Pharmaceuticals, Inc. | Orbimed Advisors LLC | Director | Mar 18, 2021 | Sale | $28.03 | 6,059 | 169,834 | 2,461,233 | Mar 18, 2021, 09:07 PM |
| ORIC | | Oric Pharmaceuticals, Inc. | Orbimed Advisors LLC | Director | Mar 16, 2021 | Sale | $27.72 | 41,353 | 1,146,305 | 2,486,082 | Mar 18, 2021, 09:07 PM |
| ORIC | | Oric Pharmaceuticals, Inc. | Orbimed Advisors LLC | Director | Mar 11, 2021 | Sale | $33.04 | 58,551 | 1,934,525 | 2,707,166 | Mar 15, 2021, 08:55 PM |
| ORIC | | Oric Pharmaceuticals, Inc. | Orbimed Advisors LLC | Director | Mar 12, 2021 | Sale | $30.29 | 90,521 | 2,741,881 | 2,616,645 | Mar 15, 2021, 08:55 PM |
| ORIC | | Oric Pharmaceuticals, Inc. | Orbimed Advisors LLC | Director | Mar 15, 2021 | Sale | $29.14 | 89,210 | 2,599,579 | 2,527,435 | Mar 15, 2021, 08:55 PM |
| CRVS | | Corvus Pharmaceuticals, Inc. | Orbimed Advisors LLC | Director | Feb 17, 2021 | Buy | $3.50 | 1,285,714 | 4,499,999 | 8,053,298 | Feb 19, 2021, 04:52 PM |
| ACET | | Adicet Bio, Inc. | Orbimed Advisors LLC | Director | Feb 12, 2021 | Award/Grant | $13.00 | 524,349 | 6,816,537 | 5,243,259 | Feb 18, 2021, 09:38 PM |
| TERN | | Terns Pharmaceuticals, Inc. | Orbimed Advisors LLC | Director | Feb 09, 2021 | Conversion | - | 3,316,204 | - | 1,989,723 | Feb 09, 2021, 03:09 PM |
| TERN | | Terns Pharmaceuticals, Inc. | Orbimed Advisors LLC | Director | Feb 09, 2021 | Buy | $17.00 | 475,000 | 8,075,000 | 2,274,723 | Feb 09, 2021, 03:09 PM |
| ARPO | | Aerpio Pharmaceuticals, Inc. | Orbimed Advisors LLC | 10% Owner | Dec 08, 2020 | Sale | $1.96 | 21,400 | 41,944 | 0 | Dec 10, 2020, 05:04 PM |
| ARPO | | Aerpio Pharmaceuticals, Inc. | Orbimed Advisors LLC | 10% Owner | Dec 08, 2020 | ATM/ITM Option Exercise | $0.96 | 21,400 | 20,544 | 21,400 | Dec 10, 2020, 05:04 PM |
| SBTX | | Silverback Therapeutics, Inc. | Orbimed Advisors LLC | Director | Dec 08, 2020 | Buy | $21.00 | 238,100 | 5,000,100 | 507,423 | Dec 08, 2020, 08:41 PM |
| SBTX | | Silverback Therapeutics, Inc. | Orbimed Advisors LLC | Director | Dec 08, 2020 | Buy | $21.00 | 952,377 | 19,999,917 | 952,377 | Dec 08, 2020, 08:41 PM |
