| ASND | ASCENDIS PHARMA A/S - ADR | 27.27% | 10,281,496 | $1,774,586,210 | | No Change | $172.6 | 13F |
| PCVX | VAXCYTE INC | 5.98% | 11,965,991 | $389,014,367 | -223,158 | -1.83% | $32.51 | 13F |
| RYTM | RHYTHM PHARMACEUTICALS INC | 5.40% | 5,561,359 | $351,422,275 | -523,053 | -8.6% | $63.19 | 13F |
| JANX | JANUX THERAPEUTICS INC | 3.97% | 11,189,693 | $258,481,908 | | No Change | $23.1 | 13F |
| CDTX | CIDARA THERAPEUTICS, INC. | 3.28% | 3,365,523 | $207,753,735 | | No Change | | 13D |
| RNA | AVIDITY BIOSCIENCES INC | 3.17% | 7,266,031 | $206,355,280 | 965,623 | 15.33% | $28.4 | 13F |
| ACLX | ARCELLX INC | 3.07% | 3,036,527 | $199,955,303 | | No Change | $65.85 | 13F |
| ETNB | 89BIO INC | 3.00% | 19,889,683 | $195,316,687 | | No Change | $9.82 | 13F |
| MLYS | Mineralys Therapeutics, Inc. | 2.87% | 7,323,750 | $186,755,625 | 1,176,470 | 19.14% | | Form 4 |
| NAMS | NEWAMSTERDAM PHARMA CO NV | 2.82% | 10,138,938 | $183,616,167 | | No Change | $18.11 | 13F |
| SION | SIONNA THERAPEUTICS INC | 2.78% | 10,445,322 | $181,226,337 | | No Change | $17.35 | 13F |
| EWTX | EDGEWISE THERAPEUTICS INC | 1.99% | 9,902,633 | $129,823,519 | 993,542 | 11.15% | $13.11 | 13F |
| LENZ | LENZ THERAPEUTICS INC | 1.88% | 4,178,823 | $122,481,302 | | No Change | $29.31 | 13F |
| WVE | WAVE LIFE SCIENCES LTD | 1.82% | 18,202,009 | $118,313,059 | | No Change | $6.5 | 13F |
| SPRY | ARS PHARMACEUTICALS, INC. | 1.81% | 10,940,977 | $106,346,296 | 80,000 | 0.74% | | 13D |
| TYRA | TYRA BIOSCIENCES INC | 1.79% | 12,198,625 | $116,740,841 | 1,561,335 | 14.68% | $9.57 | 13F |
| GHRS | GH RESEARCH PLC | 1.44% | 7,676,697 | $93,578,936 | 732,049 | 10.54% | $12.19 | 13F |
| DYN | DYNE THERAPEUTICS INC | 1.42% | 9,714,392 | $92,481,012 | | No Change | $9.52 | 13F |
| GERN | GERON CORP | 1.31% | 60,379,366 | $85,134,906 | | No Change | $1.41 | 13F |
| IRON | DISC MEDICINE INC | 1.28% | 1,577,106 | $83,523,534 | | No Change | $52.96 | 13F |
| SEPN | SEPTERNA INC | 1.14% | 6,995,858 | $73,946,219 | | No Change | $10.57 | 13F |
| FULC | FULCRUM THERAPEUTICS INC | 1.08% | 10,229,099 | $70,376,201 | | No Change | $6.88 | 13F |
| PEPG | PepGen Inc. | 1.00% | 20,064,545 | $64,206,544 | 9,375,000 | 87.70% | | Form 4 |
| VOR | VOR BIOPHARMA INC. | 1.00% | 1,988,657 | $60,455,173 | 1,988,657 | New | | 13D |
| BCAX | BICARA THERAPEUTICS INC | 0.99% | 6,955,993 | $64,621,175 | | No Change | $9.29 | 13F |
| VOR | VOR BIOPHARMA INC | 0.99% | 39,646,039 | $64,226,583 | | No Change | $1.62 | 13F |
| TSHA | TAYSHA GENE THERAPIES INC | 0.84% | 23,555,648 | $54,413,547 | 12,683,145 | 116.65% | $2.31 | 13F |
| DNTH | DIANTHUS THERAPEUTICS INC | 0.82% | 2,866,733 | $53,407,236 | | No Change | $18.63 | 13F |
| SLDB | SOLID BIOSCIENCES INC. | 0.77% | 7,997,510 | $48,304,960 | 2,186,187 | 37.62% | | 13D |
| RXST | RXSIGHT INC | 0.74% | 3,702,967 | $48,138,571 | -40,051 | -1.07% | $13 | 13F |
| SRRK | SCHOLAR ROCK HOLDING CORP | 0.62% | 1,136,453 | $40,253,165 | | No Change | $35.42 | 13F |
| TRML | TOURMALINE BIO INC | 0.62% | 2,538,925 | $40,597,411 | | No Change | $15.99 | 13F |
| CLYM | CLIMB BIO INC | 0.60% | 31,419,267 | $38,959,891 | | No Change | $1.24 | 13F |
| ASMB | Assembly Biosciences, Inc. | 0.57% | 1,530,615 | $36,122,514 | 1,530,615 | New | | 13G |
| GPCR | STRUCTURE THERAPEUTICS INC | 0.48% | 1,517,418 | $31,471,249 | | No Change | $20.74 | 13F |
| LBRX | LB PHARMACEUTICALS INC | 0.46% | 1,675,000 | $28,140,000 | 1,675,000 | New | | 13G |
| MTSR | METSERA INC | 0.30% | 675,525 | $19,218,686 | | No Change | $28.45 | 13F |
| MNPR | MONOPAR THERAPEUTICS INC | 0.28% | 511,207 | $18,290,986 | | No Change | $35.78 | 13F |
| NKTX | NKARTA INC | 0.28% | 10,805,129 | $17,936,514 | | No Change | $1.66 | 13F |
| PALI | PALISADE BIO, INC. | 0.28% | 9,935,761 | $16,890,794 | 9,935,761 | New | | 13G |
| ABOS | ACUMEN PHARMACEUTICALS INC | 0.27% | 14,932,063 | $17,321,193 | | No Change | $1.16 | 13F |
| LRMR | LARIMAR THERAPEUTICS INC | 0.27% | 6,045,351 | $17,471,064 | | No Change | $2.89 | 13F |
| FDMT | 4D MOLECULAR THERAPEUTICS IN | 0.26% | 4,563,211 | $16,929,513 | | No Change | $3.71 | 13F |
| ELVN | ENLIVEN THERAPEUTICS INC | 0.26% | 848,986 | $17,030,659 | | No Change | $20.06 | 13F |
| TVTX | TRAVERE THERAPEUTICS INC | 0.26% | 1,150,000 | $17,020,000 | | No Change | $14.8 | 13F |
| HNGE | HINGE HEALTH INC-A | 0.24% | 300,000 | $15,525,000 | 300,000 | New | $51.75 | 13F |
| ARTV | ARTIVA BIOTHERAPEUTICS INC | 0.23% | 9,853,302 | $14,878,486 | | No Change | $1.51 | 13F |
| IVVD | Invivyd, Inc. | 0.18% | 21,338,288 | $11,095,910 | 21,338,288 | New | | 13G |
| JBIO | JADE BIOSCIENCES INC | 0.16% | 1,062,326 | $10,612,637 | 1,062,326 | New | $9.99 | 13F |
| TNGX | TANGO THERAPEUTICS INC | 0.16% | 2,000,000 | $10,240,000 | 2,000,000 | New | $5.12 | 13F |
| ACRV | ACRIVON THERAPEUTICS INC | 0.15% | 8,340,508 | $9,925,205 | | No Change | $1.19 | 13F |
| CTNM | Contineum Therapeutics, Inc. | 0.15% | 2,122,000 | $9,230,700 | 2,122,000 | New | | 13G |
| ELDN | ELEDON PHARMACEUTICALS INC | 0.15% | 3,566,338 | $9,664,776 | | No Change | $2.71 | 13F |
| SABS | SAB Biotherapeutics, Inc. | 0.15% | 4,401,500 | $8,847,015 | 4,401,500 | New | | 13D |
| RCUS | ARCUS BIOSCIENCES INC | 0.14% | 1,136,364 | $9,250,003 | | No Change | $8.14 | 13F |
| PCSC | PERCEPTIVE CAPITAL SOLUTIONS | 0.12% | 750,000 | $7,965,000 | | No Change | $10.62 | 13F |
| BBNX | BETA BIONICS INC | 0.11% | 500,000 | $7,280,000 | | No Change | $14.56 | 13F |
| OMDA | OMADA HEALTH INC | 0.11% | 400,000 | $7,320,000 | 400,000 | New | $18.3 | 13F |
| HOWL | WEREWOLF THERAPEUTICS INC | 0.11% | 6,681,307 | $7,282,625 | 536,426 | 8.73% | $1.09 | 13F |
| CTMX | CYTOMX THERAPEUTICS INC | 0.09% | 2,661,331 | $6,041,221 | 1,661,331 | 166.13% | $2.27 | 13F |
| WGS | GENEDX HOLDINGS CORP | 0.08% | 58,044 | $5,358,042 | 58,044 | New | $92.31 | 13F |
| SRZN | SURROZEN INC | 0.08% | 602,626 | $5,387,476 | -76,504 | -11.27% | $8.94 | 13F |
| TXG | 10X GENOMICS INC-CLASS A | 0.08% | 475,343 | $5,504,472 | -1,468,904 | -75.55% | $11.58 | 13F |
| ACET | ADICET BIO INC | 0.07% | 7,541,000 | $4,600,010 | | No Change | $0.61 | 13F |
| AVTX | AVALO THERAPEUTICS INC | 0.07% | 932,973 | $4,655,535 | -34,027 | -3.52% | $4.99 | 13F |
| MBX | MBX BIOSCIENCES INC | 0.07% | 377,841 | $4,311,166 | -1,133,493 | -75% | $11.41 | 13F |
| TARA | PROTARA THERAPEUTIC INC | 0.05% | 1,039,295 | $3,149,064 | -2,360,705 | -69.43% | $3.03 | 13F |
| NAMSW | NEWAMSTERDAM PHARMA CO NV-27 | 0.04% | 333,333 | $2,666,664 | | No Change | $8 | 13F |
| ACHC | ACADIA HEALTHCARE CO INC | 0.03% | 89,262 | $2,025,355 | -127,738 | -58.87% | $22.69 | 13F |
| IFRX | INFLARX NV | 0.02% | 1,973,233 | $1,558,854 | 1,973,233 | New | $0.79 | 13F |
| ACRS | ACLARIS THERAPEUTICS INC | | | | -4,666,667 | Exited | | 13F |
| AVTE | AEROVATE THERAPEUTICS INC | | | | -9,192,092 | Exited | | 13F |
| ALEC | ALECTOR INC | | | | -9,695,228 | Exited | | 13F |
| APGE | APOGEE THERAPEUTICS INC | | | | -1,569,491 | Exited | | 13F |
| ATXS | ASTRIA THERAPEUTICS INC | | | | -5,105,213 | Exited | | 13F |
| BCYC | BICYCLE THERAPEUTICS PLC-ADR | | | | -1,093,477 | Exited | | 13F |
| BIOA | BIOAGE LABS INC | | | | -1,052,494 | Exited | | 13F |
| BOLD | BOUNDLESS BIO INC | | | | -2,180,631 | Exited | | 13F |
| DRUG | Bright Minds Biosciences Inc | | | | -206,427 | Exited | | 13F |
| CBLL | CERIBELL INC | | | | -824,582 | Exited | | 13F |
| DAWN | DAY ONE BIOPHARMACEUTICALS I | | | | -5,755,577 | Exited | | 13F |
| EYPT | EYEPOINT PHARMACEUTICALS INC | | | | -3,181,818 | Exited | | 13F |
| GKOS | GLAUKOS CORP | | | | -190,256 | Exited | | 13F |
| HUMA | HUMACYTE INC | | | | -3,312,356 | Exited | | 13F |
| IDYA | IDEAYA BIOSCIENCES INC | | | | -1,347,252 | Exited | | 13F |
| INSM | INSMED INC | | | | -200,000 | Exited | | 13F |
| ITOS | ITEOS THERAPEUTICS INC | | | | -3,649,057 | Exited | | 13F |
| KURA | KURA ONCOLOGY INC | | | | -4,004,610 | Exited | | 13F |
| LXEO | LEXEO THERAPEUTICS INC | | | | -546,554 | Exited | | 13F |
| NRIX | NURIX THERAPEUTICS INC | | | | -1,333,333 | Exited | | 13F |
| SCLX | SCILEX HOLDING CO | | | | -1,036,218 | Exited | | 13F |
| SERA | SERA PROGNOSTICS INC-A | | | | -3,032,808 | Exited | | 13F |
| STRO | SUTRO BIOPHARMA INC | | | | -4,434,637 | Exited | | 13F |
| XNCR | XENCOR INC | | | | -575,000 | Exited | | 13F |
| ZLAB | ZAI LAB LTD-ADR | | | | -1,295,040 | Exited | | 13F |
| ZURA | ZURA BIO LTD | | | | -3,217,503 | Exited | | 13F |
| URGN | UROGEN PHARMA LTD | | | | -3,206,271 | Exited | | 13F |
| IMTX | IMMATICS NV | | | | -1,750,000 | Exited | | 13F |
