| ASND | ASCENDIS PHARMA A/S - ADR | 19.52% | 10,281,496 | $2,351,686,580 | | No Change | $228.73 | 13F |
| PCVX | VAXCYTE INC | 5.53% | 11,474,599 | $666,788,948 | 750,000 | 6.99% | $58.11 | 13F |
| RYTM | RHYTHM PHARMACEUTICALS INC | 4.81% | 6,666,837 | $579,814,814 | | No Change | $86.97 | 13F |
| PBLS | Parabilis Medicines, Inc. | 4.34% | 26,285,093 | $525,701,860 | 26,285,093 | New | | Form 4 |
| TYRA | TYRA BIOSCIENCES INC | 3.88% | 12,198,625 | $467,207,338 | | No Change | $38.3 | 13F |
| SION | SIONNA THERAPEUTICS INC | 3.30% | 9,905,045 | $397,093,254 | | No Change | $40.09 | 13F |
| CLYM | Climb Bio, Inc. | 3.08% | 23,249,186 | $299,914,499 | 11,948,247 | 105.73% | | 13D |
| EWTX | EDGEWISE THERAPEUTICS INC | 2.73% | 10,428,437 | $328,495,766 | | No Change | $31.5 | 13F |
| NAMS | NEWAMSTERDAM PHARMA CO NV | 2.54% | 9,550,191 | $305,701,614 | | No Change | $32.01 | 13F |
| WVE | WAVE LIFE SCIENCES LTD. | 2.30% | 34,225,506 | $259,771,591 | 7,250,001 | 26.88% | | 13D |
| NUVL | NUVALENT INC-A | 2.16% | 2,534,145 | $259,623,155 | 654,088 | 34.79% | $102.45 | 13F |
| DNTH | DIANTHUS THERAPEUTICS INC | 1.82% | 2,611,733 | $219,176,633 | 1,000,000 | 62.05% | $83.92 | 13F |
| MLYS | MINERALYS THERAPEUTICS INC | 1.73% | 7,692,750 | $208,396,598 | 369,000 | 5.04% | $27.09 | 13F |
| SGP | SPYGLASS PHARMA INC | 1.73% | 8,021,117 | $207,827,141 | 8,021,117 | New | $25.91 | 13F |
| COAG | Hemab Therapeutics Holdings, Inc. | 1.68% | 7,808,628 | $195,059,527 | 7,808,628 | New | | Form 4 |
| ARTV | Artiva Biotherapeutics, Inc. | 1.43% | 18,137,650 | $162,331,968 | 8,284,348 | 84.08% | | Form 4 |
| SEPN | SEPTERNA INC | 1.40% | 6,995,858 | $168,110,468 | | No Change | $24.03 | 13F |
| IRON | DISC MEDICINE INC | 1.30% | 2,450,221 | $156,667,131 | 474,089 | 23.99% | $63.94 | 13F |
| JANX | JANUX THERAPEUTICS INC | 1.29% | 11,189,693 | $155,536,733 | | No Change | $13.9 | 13F |
| BCRX | BIOCRYST PHARMACEUTICALS INC | 1.25% | 15,827,186 | $150,674,811 | | No Change | $9.52 | 13F |
| BCAX | BICARA THERAPEUTICS INC | 1.20% | 7,255,993 | $144,321,701 | 300,000 | 4.31% | $19.89 | 13F |
| SLDB | SOLID BIOSCIENCES INC. | 1.02% | 12,036,126 | $99,899,846 | 2,696,148 | 28.87% | | 13D |
| PRAX | PRAXIS PRECISION MEDICINES I | 1.00% | 373,787 | $120,430,434 | | No Change | $322.19 | 13F |
| GHRS | GH RESEARCH PLC | 0.90% | 7,676,697 | $107,934,360 | | No Change | $14.06 | 13F |
| ZLAB | ZAI LAB LTD-ADR | 0.89% | 5,707,262 | $107,353,598 | 5,707,262 | New | $18.81 | 13F |
| TSHA | TAYSHA GENE THERAPIES INC | 0.87% | 23,555,648 | $105,293,747 | | No Change | $4.47 | 13F |
| GERN | GERON CORP | 0.79% | 63,771,366 | $95,019,335 | | No Change | $1.49 | 13F |
| SPRY | ARS PHARMACEUTICALS INC | 0.72% | 10,860,977 | $87,213,645 | | No Change | $8.03 | 13F |
| SRPT | SAREPTA THERAPEUTICS INC | 0.70% | 3,902,596 | $84,920,489 | 3,902,596 | New | $21.76 | 13F |
| SYRE | SPYRE THERAPEUTICS INC | 0.68% | 1,621,620 | $81,794,513 | | No Change | $50.44 | 13F |
| EVMN | EVOMMUNE INC | 0.67% | 3,494,638 | $80,341,728 | 35,868 | 1.04% | $22.99 | 13F |
| IKT | Inhibikase Therapeutics, Inc. | 0.54% | 25,000,000 | $51,000,000 | 25,000,000 | New | | 13G |
| SANA | Sana Biotechnology, Inc. | 0.54% | 18,750,000 | $58,875,000 | 18,750,000 | New | | 13G |
| DMRA | DAMORA THERAPEUTICS INC | 0.52% | 2,399,310 | $62,142,129 | 2,399,310 | New | $25.9 | 13F |
| XNCR | XENCOR INC | 0.49% | 4,897,237 | $59,060,678 | 4,897,237 | New | $12.06 | 13F |
| LBRX | LB PHARMACEUTICALS INC | 0.45% | 2,208,604 | $54,464,175 | | No Change | $24.66 | 13F |
| JBIO | JADE BIOSCIENCES INC | 0.43% | 3,671,083 | $51,578,716 | | No Change | $14.05 | 13F |
| ABOS | ACUMEN PHARMACEUTICALS INC | 0.41% | 20,992,669 | $49,542,699 | 6,060,606 | 40.59% | $2.36 | 13F |
| FULC | FULCRUM THERAPEUTICS INC | 0.39% | 6,053,960 | $46,433,873 | | No Change | $7.67 | 13F |
| FDMT | 4D MOLECULAR THERAPEUTICS IN | 0.39% | 5,049,779 | $47,013,442 | -603,432 | -10.67% | $9.31 | 13F |
| CAPR | CAPRICOR THERAPEUTICS INC | 0.38% | 1,507,844 | $45,838,458 | | No Change | $30.4 | 13F |
| ALT | Altimmune, Inc. | 0.33% | 13,000,000 | $37,050,000 | 13,000,000 | New | | 13G |
| IPSC | CENTURY THERAPEUTICS INC | 0.33% | 17,754,430 | $40,125,012 | 17,754,430 | New | $2.26 | 13F |
| LENZ | LENZ THERAPEUTICS INC | 0.32% | 4,178,823 | $38,236,230 | | No Change | $9.15 | 13F |
| OLMA | OLEMA PHARMACEUTICALS INC | 0.32% | 2,600,000 | $38,766,000 | | No Change | $14.91 | 13F |
| VOR | Vor Biopharma Inc. | 0.31% | 2,402,095 | $37,881,038 | -3,002,903 | -55.56% | | Form 4 |
| MNPR | MONOPAR THERAPEUTICS INC | 0.30% | 667,207 | $36,556,272 | | No Change | $54.79 | 13F |
| EDIT | Editas Medicine, Inc. | 0.29% | 8,889,000 | $31,733,730 | 8,889,000 | New | | 13G |
| PEPG | PEPGEN INC | 0.29% | 20,064,545 | $35,514,245 | | No Change | $1.77 | 13F |
| AGEN | Agenus Inc. | 0.28% | 4,344,772 | $26,590,005 | 4,344,772 | New | | 13G |
| PRLD | Prelude Therapeutics Incorporated | 0.27% | 6,477,309 | $29,925,168 | 6,477,309 | New | | 13G |
| DSGN | DESIGN THERAPEUTICS INC | 0.26% | 2,972,973 | $31,632,433 | 1,511,592 | 103.44% | $10.64 | 13F |
| ASMB | ASSEMBLY BIOSCIENCES INC | 0.24% | 1,020,410 | $28,316,378 | | No Change | $27.75 | 13F |
| BIOA | BIOAGE LABS INC | 0.24% | 1,650,648 | $28,869,834 | 1,650,648 | New | $17.49 | 13F |
| LXEO | LEXEO THERAPEUTICS INC | 0.24% | 5,000,000 | $28,700,000 | | No Change | $5.74 | 13F |
| MIRM | MIRUM PHARMACEUTICALS INC | 0.24% | 318,554 | $29,428,019 | 318,554 | New | $92.38 | 13F |
| RZLT | REZOLUTE INC | 0.23% | 9,180,000 | $27,999,000 | | No Change | $3.05 | 13F |
| ALXO | ALX ONCOLOGY HOLDINGS INC | 0.22% | 13,011,849 | $26,088,757 | 13,011,849 | New | $2 | 13F |
| ACRV | ACRIVON THERAPEUTICS, INC. | 0.22% | 12,284,906 | $24,201,265 | 3,944,398 | 47.29% | | 13D |
| AKTS | AKTIS ONCOLOGY INC | 0.22% | 1,503,084 | $26,890,173 | 1,503,084 | New | $17.89 | 13F |
| QTTB | Q32 Bio Inc. | 0.22% | 2,332,457 | $24,047,632 | 2,332,457 | New | | 13G |
| ACRS | ACLARIS THERAPEUTICS INC | 0.21% | 6,804,072 | $25,515,270 | 6,804,072 | New | $3.75 | 13F |
| OVID | OVID THERAPEUTICS INC | 0.20% | 10,714,000 | $23,785,080 | | No Change | $2.22 | 13F |
| NKTX | NKARTA INC | 0.19% | 10,805,129 | $22,798,822 | | No Change | $2.11 | 13F |
| GRAL | GRAIL INC | 0.18% | 428,266 | $22,132,787 | | No Change | $51.68 | 13F |
| TVTX | TRAVERE THERAPEUTICS INC | 0.18% | 746,841 | $22,188,646 | 746,841 | New | $29.71 | 13F |
| CCCC | C4 THERAPEUTICS INC | 0.17% | 8,000,000 | $21,040,000 | | No Change | $2.63 | 13F |
| RLMD | RELMADA THERAPEUTICS INC | 0.17% | 2,947,369 | $20,513,688 | 2,947,369 | New | $6.96 | 13F |
| BNTC | BENITEC BIOPHARMA INC | 0.16% | 1,850,000 | $19,702,500 | | No Change | $10.65 | 13F |
| DRUG | BRIGHT MINDS BIOSCIENCES INC | 0.16% | 265,000 | $19,337,050 | 265,000 | New | $72.97 | 13F |
| STRO | SUTRO BIOPHARMA INC | 0.15% | 715,307 | $17,818,297 | 715,307 | New | $24.91 | 13F |
| AVR | ANTERIS TECHNOLOGIES GLOBAL | 0.14% | 3,000,000 | $16,650,000 | 3,000,000 | New | $5.55 | 13F |
| CTNM | CONTINEUM THERAPEUTICS INC-A | 0.14% | 1,296,012 | $16,925,917 | -883,699 | -40.54% | $13.06 | 13F |
| INSP | INSPIRE MEDICAL SYSTEMS INC | 0.14% | 325,663 | $16,797,698 | 183,699 | 129.4% | $51.58 | 13F |
| OKUR | ONKURE THERAPEUTICS INC-A | 0.14% | 3,998,333 | $16,553,099 | 3,998,333 | New | $4.14 | 13F |
| SABS | SAB BIOTHERAPEUTICS INC | 0.14% | 4,401,500 | $16,857,745 | | No Change | $3.83 | 13F |
| HNGE | HINGE HEALTH INC-A | 0.12% | 364,613 | $14,059,477 | 284,500 | 355.12% | $38.56 | 13F |
| WGS | GENEDX HOLDINGS CORP | 0.11% | 209,887 | $13,478,943 | 151,843 | 261.6% | $64.22 | 13F |
| WAY | WAYSTAR HOLDING CORP | 0.11% | 529,400 | $12,763,834 | 385,000 | 266.62% | $24.11 | 13F |
| HLXC | HELIX ACQUISITION CORP-CL A | 0.11% | 1,250,000 | $12,700,000 | 1,250,000 | New | $10.16 | 13F |
| RNA | ATRIUM THERAPEUTICS INC | 0.10% | 864,102 | $11,553,044 | 864,102 | New | $13.37 | 13F |
| PALI | PALISADE BIO INC | 0.10% | 7,124,116 | $12,467,203 | | No Change | $1.75 | 13F |
| KPTI | KARYOPHARM THERAPEUTICS INC | 0.09% | 1,917,354 | $10,679,662 | 1,917,354 | New | $5.57 | 13F |
| AVTX | AVALO THERAPEUTICS INC | 0.08% | 662,968 | $9,898,112 | | No Change | $14.93 | 13F |
| ACET | ADICET BIO INC | 0.07% | 1,182,624 | $8,053,669 | 234,375 | 24.72% | $6.81 | 13F |
| PCSC | PERCEPTIVE CAPITAL SOLUTIONS | 0.07% | 750,000 | $8,227,500 | | No Change | $10.97 | 13F |
| NAMSW | NEWAMSTERDAM PHARMA CO NV-27 | 0.06% | 333,333 | $6,679,993 | | No Change | $20.04 | 13F |
| CRVS | CORVUS PHARMACEUTICALS INC | 0.05% | 450,000 | $6,583,500 | 450,000 | New | $14.63 | 13F |
| EQ | EQUILLIUM INC | 0.05% | 3,096,336 | $6,192,672 | 3,096,336 | New | $2 | 13F |
| RANI | RANI THERAPEUTICS HOLDINGS-A | 0.05% | 8,500,000 | $6,245,800 | | No Change | $0.73 | 13F |
| MGNX | MACROGENICS INC | 0.04% | 1,864,176 | $5,387,469 | 1,864,176 | New | $2.89 | 13F |
| MPLT | MAPLIGHT THERAPEUTICS INC | 0.04% | 248,294 | $5,047,817 | 248,294 | New | $20.33 | 13F |
| JATT | JATT II Acquisition Corp | 0.04% | 500,000 | $4,080,000 | 500,000 | New | | 13G |
| PTN | PALATIN TECHNOLOGIES INC | 0.01% | 70,000 | $1,219,400 | | No Change | $17.42 | 13F |
| HOWL | WEREWOLF THERAPEUTICS, INC. | 0.00734% | 1,985,541 | $714,795 | -4,695,766 | -70.28% | | 13D |
| IVVD | INVIVYD INC | | | | -17,119,096 | Exited | | 13F |
| ACLX | ARCELLX INC | | | | -1,267,156 | Exited | | 13F |
| RNA | AVIDITY BIOSCIENCES INC | | | | -8,641,031 | Exited | | 13F |
| BLTE | BELITE BIO INC - ADR | | | | -432,484 | Exited | | 13F |
| CDTX | CIDARA THERAPEUTICS INC | | | | -3,365,523 | Exited | | 13F |
| HCAT | HEALTH CATALYST INC | | | | -793,749 | Exited | | 13F |
| MDLN | MEDLINE INC-CL A | | | | -335,000 | Exited | | 13F |
| KIDS | ORTHOPEDIATRICS CORP | | | | -109,959 | Exited | | 13F |
| PGNY | PROGYNY INC | | | | -96,628 | Exited | | 13F |
| QGEN | QIAGEN N.V. | | | | -43,976 | Exited | | 13F |
