| KYMR | Kymera Therapeutics, Inc. | 1.73% | 8,657,242 | $992,725,940 | | No Change | $114.67 | 13F |
| KOD | Kodiak Sciences Inc. | 1.35% | 19,919,186 | $776,051,487 | | No Change | $38.96 | 13F |
| RYTM | Rhythm Pharmaceuticals, Inc. | 1.08% | 5,604,483 | $622,265,747 | | No Change | $111.03 | 13F |
| PRAX | Praxis Precision Medicines, Inc. | 1.02% | 1,753,198 | $586,953,158 | | No Change | $334.79 | 13F |
| ALKS | Alkermes plc | 0.91% | 10,012,267 | $524,592,729 | | No Change | $52.39 | 13F |
| GRAL | GRAIL, Inc. | 0.48% | 4,028,614 | $275,033,478 | | No Change | $68.27 | 13F |
| ARWR | Arrowhead Pharmaceuticals, Inc. | 0.28% | 1,992,783 | $162,431,742 | | No Change | $81.51 | 13F |
| IONS | Ionis Pharmaceuticals, Inc. | 0.28% | 2,047,727 | $162,364,274 | | No Change | $79.29 | 13F |
| NRIX | Nurix Therapeutics, Inc. | 0.20% | 4,658,556 | $113,016,569 | | No Change | $24.26 | 13F |
| STOK | Stoke Therapeutics, Inc. | 0.19% | 3,336,697 | $109,176,726 | | No Change | $32.72 | 13F |
| GLUE | Monte Rosa Therapeutics, Inc. | 0.18% | 4,345,736 | $105,166,811 | | No Change | $24.2 | 13F |
| CRNX | Crinetics Pharmaceuticals, Inc. | 0.15% | 2,351,465 | $87,991,820 | | No Change | $37.42 | 13F |
| DNTH | Dianthus Therapeutics, Inc. | 0.14% | 852,164 | $83,068,947 | | No Change | $97.48 | 13F |
| GPCR | Structure Therapeutics Inc. | 0.13% | 1,432,529 | $76,883,831 | | No Change | $53.67 | 13F |
| RAPP | Rapport Therapeutics, Inc. | 0.11% | 1,547,090 | $64,467,240 | | No Change | $41.67 | 13F |
| ALMS | Alumis Inc. | 0.10% | 2,012,500 | $56,631,750 | | No Change | $28.14 | 13F |
| MIRM | Mirum Pharmaceuticals, Inc. | 0.09% | 445,975 | $52,210,293 | | No Change | $117.07 | 13F |
| PRLD | Prelude Therapeutics Inc. | 0.09% | 10,123,824 | $53,959,982 | | No Change | $5.33 | 13F |
| BCYC | Bicycle Therapeutics plc | 0.08% | 10,885,357 | $46,153,914 | | No Change | $4.24 | 13F |
| ELVN | Enliven Therapeutics, Inc. | 0.08% | 905,191 | $45,938,443 | | No Change | $50.75 | 13F |
| AKTS | Aktis Oncology, Inc. | 0.06% | 996,351 | $32,112,393 | | No Change | $32.23 | 13F |
| TRDA | Entrada Therapeutics, Inc. | 0.06% | 5,072,730 | $37,335,293 | | No Change | $7.36 | 13F |
| NGNE | Neurogene Inc. | 0.05% | 991,691 | $31,188,682 | | No Change | $31.45 | 13F |
| TSHA | Taysha Gene Therapies, Inc. | 0.05% | 4,004,756 | $27,272,388 | | No Change | $6.81 | 13F |
| IRON | Disc Medicine, Inc. | 0.04% | 349,657 | $25,573,913 | | No Change | $73.14 | 13F |
| GENB | Generate Biomedicines, Inc. | 0.04% | 1,423,602 | $24,016,166 | | No Change | $16.87 | 13F |
| TECX | Tectonic Therapeutic, Inc. | 0.04% | 607,788 | $20,892,713 | | No Change | $34.38 | 13F |
| ABSI | Absci Corporation | 0.04% | 2,134,803 | $24,742,367 | | No Change | $11.59 | 13F |
| DBVT | DBV Technologies S.A. | 0.04% | 1,461,425 | $23,967,370 | | No Change | $16.4 | 13F |
| XENE | Xenon Pharmaceuticals Inc. | 0.04% | 370,208 | $22,345,755 | | No Change | $60.36 | 13F |
| CTMX | CytomX Therapeutics, Inc. | 0.03% | 4,975,826 | $18,659,348 | | No Change | $3.75 | 13F |
| DYN | Dyne Therapeutics, Inc. | 0.03% | 813,449 | $18,066,702 | | No Change | $22.21 | 13F |
| SION | Sionna Therapeutics, Inc. | 0.03% | 400,000 | $17,596,000 | | No Change | $43.99 | 13F |
| XNCR | Xencor, Inc. | 0.03% | 1,102,106 | $17,743,907 | | No Change | $16.1 | 13F |
| BNTX | BioNTech SE | 0.02% | 119,743 | $11,142,086 | | No Change | $93.05 | 13F |
| EVMN | Evommune, Inc. | 0.02% | 847,390 | $11,261,813 | | No Change | $13.29 | 13F |
| MPLT | MapLight Therapeutics, Inc. | 0.02% | 364,705 | $13,071,027 | | No Change | $35.84 | 13F |
| SERA | Sera Prognostics, Inc. | 0.02% | 5,498,170 | $10,006,669 | | No Change | $1.82 | 13F |
| EIKN | Eikon Therapeutics, Inc. | 0.01% | 555,555 | $7,249,993 | | No Change | $13.05 | 13F |
| LBRX | LB Pharmaceuticals Inc. | 0.01% | 200,000 | $6,491,000 | | No Change | $32.46 | 13F |
| SGMT | Sagimet Biosciences Inc. | 0.01% | 952,996 | $7,366,659 | | No Change | $7.73 | 13F |
| VTVT | vTv Therapeutics, Inc. | 0.00971% | 148,314 | $5,584,022 | | No Change | $37.65 | 13F |
| WVE | Wave Life Sciences Ltd. | 0.00831% | 822,638 | $4,779,527 | | No Change | $5.81 | 13F |
| TARA | Protara Therapeutics, Inc. | 0.00645% | 971,614 | $3,711,565 | | No Change | $3.82 | 13F |
| TCRX | TScan Therapeutics, Inc. | 0.00475% | 2,784,792 | $2,729,375 | | No Change | $0.98 | 13F |
| SKYE | Skye Bioscience, Inc. | 0.00190% | 1,575,243 | $1,092,116 | | No Change | $0.69 | 13F |
| SANA | Sana Biotechnology, Inc. | 0.00188% | 310,483 | $1,083,586 | | No Change | $3.49 | 13F |
| ALGS | Aligos Therapeutics, Inc. | 0.00083% | 83,055 | $479,227 | | No Change | $5.77 | 13F |
| TYRA | Tyra Biosciences, Inc. | 0.00059% | 10,607 | $338,788 | | No Change | $31.94 | 13F |
| SRZNW | Surrozen, Inc. Warrants @ $172.50 8/11/2026 (15 FOR 1) | 0.00002% | 833,333 | $13,750 | | No Change | $0.02 | 13F |
