| ONC | BeOne Medicines Ltd. | 19.92% | 8,799,053 | $2,129,986,760 | | No Change | $242.07 | 13F |
| INCY | Incyte Corporation | 19.58% | 30,743,275 | $2,093,617,028 | 3,322 | 0.01% | $68.1 | 13F |
| ACAD | ACADIA Pharmaceuticals Inc. | 8.65% | 42,896,690 | $925,281,603 | 18,774 | 0.04% | $21.57 | 13F |
| INSM | Insmed Incorporated | 7.26% | 7,712,900 | $776,226,256 | 2,332,274 | 43.35% | $100.64 | 13F |
| MDGL | MADRIGAL PHARMACEUTICALS, INC. | 7.02% | 1,947,968 | $750,279,355 | -28,050 | -1.42% | | Form 4 |
| SMMT | Summit Therapeutics Inc. | 6.71% | 33,722,974 | $717,624,887 | 9,298,109 | 38.07% | $21.28 | 13F |
| RYTM | Rhythm Pharmaceuticals, Inc. | 3.31% | 5,604,483 | $354,147,281 | | No Change | $63.19 | 13F |
| RVMD | Revolution Medicines, Inc. | 3.22% | 9,364,972 | $344,537,320 | 1,428,000 | 17.99% | $36.79 | 13F |
| CELC | Celcuity Inc. | 2.93% | 7,745,692 | $309,130,568 | 2,295,247 | 42.11% | | 13D |
| KYMR | Kymera Therapeutics, Inc. | 2.71% | 6,651,429 | $290,268,362 | 655,500 | 10.93% | $43.64 | 13F |
| ALKS | Alkermes plc | 1.72% | 6,410,603 | $183,407,352 | 1,927,318 | 42.99% | $28.61 | 13F |
| REPL | Replimune Group, Inc. | 0.96% | 11,045,336 | $102,611,171 | | No Change | $9.29 | 13F |
| RARE | Ultragenyx Pharmaceutical Inc. | 0.94% | 2,772,692 | $100,815,081 | 1,196,578 | 75.92% | $36.36 | 13F |
| EWTX | Edgewise Therapeutics, Inc. | 0.90% | 7,305,940 | $95,780,873 | 1,150,000 | 18.68% | $13.11 | 13F |
| ABCL | AbCellera Biologics Inc. | 0.88% | 27,525,640 | $94,412,945 | | No Change | $3.43 | 13F |
| IMVT | Immunovant, Inc. | 0.82% | 5,457,881 | $87,326,096 | | No Change | $16 | 13F |
| GRAL | GRAIL, Inc. | 0.78% | 1,630,125 | $83,821,028 | | No Change | $51.42 | 13F |
| KNSA | Kiniksa Pharmaceuticals International, plc | 0.73% | 2,824,669 | $78,158,591 | 6,346 | 0.23% | $27.67 | 13F |
| BCYC | Bicycle Therapeutics plc | 0.71% | 10,885,357 | $75,653,231 | | No Change | $6.95 | 13F |
| IMCR | Immunocore Holdings plc | 0.68% | 2,322,656 | $72,884,945 | | No Change | $31.38 | 13F |
| KOD | Kodiak Sciences Inc. | 0.60% | 17,310,490 | $64,568,128 | | No Change | $3.73 | 13F |
| IMTX | Immatics N.V. | 0.51% | 10,168,901 | $54,708,687 | 2,893,071 | 39.76% | $5.38 | 13F |
| DNLI | Denali Therapeutics Inc. | 0.49% | 3,731,695 | $52,206,413 | | No Change | $13.99 | 13F |
| STOK | Stoke Therapeutics, Inc. | 0.49% | 4,633,838 | $52,594,061 | | No Change | $11.35 | 13F |
| GPCR | Structure Therapeutics Inc. | 0.49% | 2,508,767 | $52,031,828 | 2,147,202 | 593.86% | $20.74 | 13F |
| IDYA | IDEAYA Biosciences, Inc. | 0.42% | 2,118,728 | $44,535,663 | 1,056,605 | 99.48% | $21.02 | 13F |
| NRIX | Nurix Therapeutics, Inc. | 0.41% | 3,882,125 | $44,217,404 | | No Change | $11.39 | 13F |
| ROIV | Roivant Sciences Ltd. | 0.40% | 3,767,773 | $42,462,802 | | No Change | $11.27 | 13F |
| BNTX | BioNTech SE | 0.37% | 368,923 | $39,279,232 | 323,892 | 719.26% | $106.47 | 13F |
| TRDA | Entrada Therapeutics, Inc. | 0.31% | 4,865,819 | $32,698,304 | | No Change | $6.72 | 13F |
| MRUS | Merus N.V. | 0.28% | 574,377 | $30,212,230 | 350,877 | 156.99% | $52.6 | 13F |
| PRAX | Praxis Precision Medicines, Inc. | 0.27% | 689,488 | $28,992,970 | 357,955 | 107.97% | $42.05 | 13F |
| NTLA | Intellia Therapeutics, Inc. | 0.23% | 2,675,674 | $25,097,822 | 2,031,558 | 315.4% | $9.38 | 13F |
| VRDN | Viridian Therapeutics, Inc. | 0.23% | 1,744,406 | $24,386,796 | 1,744,406 | New | $13.98 | 13F |
| GLUE | Monte Rosa Therapeutics, Inc. | 0.21% | 4,916,095 | $22,171,588 | | No Change | $4.51 | 13F |
| VRNA | Verona Pharma plc | 0.20% | 223,843 | $21,171,071 | | No Change | $94.58 | 13F |
| ARGX | argenx SE | 0.19% | 37,760 | $20,814,067 | -40,000 | -51.44% | $551.22 | 13F |
| PCVX | Vaxcyte, Inc. | 0.19% | 640,885 | $20,835,171 | | No Change | $32.51 | 13F |
| VERV | Verve Therapeutics, Inc. | 0.18% | 1,691,530 | $18,995,882 | | No Change | $11.23 | 13F |
| CERS | Cerus Corporation | 0.17% | 12,883,844 | $18,166,220 | -6,467,243 | -33.42% | $1.41 | 13F |
| IRON | Disc Medicine, Inc. | 0.17% | 337,050 | $17,850,168 | 260,000 | 337.44% | $52.96 | 13F |
| AKRO | Akero Therapeutics, Inc. | 0.16% | 324,630 | $17,322,257 | -224,083 | -40.84% | $53.36 | 13F |
| BPMC | Blueprint Medicines Corporation | 0.15% | 125,538 | $16,091,461 | 125,538 | New | $128.18 | 13F |
| ARWR | Arrowhead Pharmaceuticals, Inc. | 0.14% | 939,174 | $14,838,949 | 939,174 | New | $15.8 | 13F |
| DNTH | Dianthus Therapeutics, Inc. | 0.14% | 789,759 | $14,713,210 | 789,759 | New | $18.63 | 13F |
| NGNE | Neurogene Inc. | 0.14% | 991,691 | $14,825,780 | -494,509 | -33.27% | $14.95 | 13F |
| SERA | Sera Prognostics, Inc. | 0.14% | 5,498,170 | $15,229,931 | | No Change | $2.77 | 13F |
| CLDX | Celldex Therapeutics, Inc. | 0.13% | 665,370 | $13,540,280 | 417,726 | 168.68% | $20.35 | 13F |
| DBVT | DBV Technologies S.A. | 0.13% | 1,461,425 | $13,386,507 | | No Change | $9.16 | 13F |
| XENE | Xenon Pharmaceuticals Inc. | 0.11% | 370,208 | $11,587,510 | 22,800 | 6.56% | $31.3 | 13F |
| ACLX | Arcellx, Inc. | 0.10% | 166,825 | $10,985,426 | 166,825 | New | $65.85 | 13F |
| CDTX | Cidara Therapeutics, Inc. | 0.10% | 227,272 | $11,070,419 | 227,272 | New | $48.71 | 13F |
| NUVL | Nuvalent, Inc. | 0.10% | 143,937 | $10,982,393 | 143,937 | New | $76.3 | 13F |
| SYRE | Spyre Therapeutics, Inc. | 0.09% | 626,703 | $9,381,744 | 626,703 | New | $14.97 | 13F |
| TSHA | Taysha Gene Therapies, Inc. | 0.09% | 4,004,756 | $9,250,986 | | No Change | $2.31 | 13F |
| CRNX | Crinetics Pharmaceuticals, Inc. | 0.08% | 280,000 | $8,052,800 | 280,000 | New | $28.76 | 13F |
| PRLD | Prelude Therapeutics Inc. | 0.08% | 10,123,824 | $8,194,223 | | No Change | $0.81 | 13F |
| CTMX | CytomX Therapeutics, Inc. | 0.07% | 3,484,226 | $7,909,193 | 3,484,226 | New | $2.27 | 13F |
| SGMT | Sagimet Biosciences Inc. | 0.07% | 952,996 | $7,261,830 | | No Change | $7.62 | 13F |
| AGIO | Agios Pharmaceuticals, Inc. | 0.06% | 189,866 | $6,314,943 | 189,866 | New | $33.26 | 13F |
| RAPP | Rapport Therapeutics, Inc. | 0.06% | 550,090 | $6,254,523 | 550,090 | New | $11.37 | 13F |
| SION | Sionna Therapeutics, Inc. | 0.06% | 400,000 | $6,940,000 | | No Change | $17.35 | 13F |
| SKYE | Skye Bioscience, Inc. | 0.06% | 1,450,638 | $6,063,667 | | No Change | $4.18 | 13F |
| DSGN | Design Therapeutics, Inc. | 0.05% | 1,712,882 | $5,772,412 | -30,843 | -1.77% | $3.37 | 13F |
| KALA | KALA BIO, Inc. | 0.05% | 1,201,894 | $5,721,015 | | No Change | $4.76 | 13F |
| SANA | Sana Biotechnology, Inc. | 0.05% | 2,030,949 | $5,544,491 | | No Change | $2.73 | 13F |
| XNCR | Xencor, Inc. | 0.05% | 670,431 | $5,269,588 | | No Change | $7.86 | 13F |
| ALMS | Alumis Inc. | 0.04% | 1,562,500 | $4,687,500 | | No Change | $3 | 13F |
| RLAY | Relay Therapeutics, Inc. | 0.04% | 1,160,117 | $4,014,005 | | No Change | $3.46 | 13F |
| TCRX | TScan Therapeutics, Inc. | 0.04% | 2,784,792 | $4,037,948 | | No Change | $1.45 | 13F |
| FATE | Fate Therapeutics, Inc. | 0.03% | 2,485,018 | $2,783,220 | -773,384 | -23.74% | $1.12 | 13F |
| VIR | Vir Biotechnology, Inc. | 0.03% | 542,539 | $2,734,397 | | No Change | $5.04 | 13F |
| CADL | Candel Therapeutics, Inc. | 0.02% | 355,112 | $1,796,867 | -2,082,077 | -85.43% | $5.06 | 13F |
| TECX | Tectonic Therapeutic, Inc. | 0.02% | 100,000 | $1,987,000 | | No Change | $19.87 | 13F |
| ELVN | Enliven Therapeutics, Inc. | 0.02% | 114,833 | $2,303,550 | | No Change | $20.06 | 13F |
| TARA | Protara Therapeutics, Inc. | 0.02% | 536,832 | $1,626,601 | | No Change | $3.03 | 13F |
| WVE | Wave Life Sciences Ltd. | 0.02% | 344,063 | $2,236,410 | | No Change | $6.5 | 13F |
| CTNM | Contineum Therapeutics, Inc. | 0.01% | 312,500 | $1,240,625 | | No Change | $3.97 | 13F |
| RCKT | Rocket Pharmaceuticals, Inc. | 0.01% | 552,079 | $1,352,594 | -545,000 | -49.68% | $2.45 | 13F |
| VTVT | vTv Therapeutics, Inc. | 0.01% | 97,314 | $1,459,710 | | No Change | $15 | 13F |
| HOOK | HOOKIPA Pharma Inc. | 0.00954% | 812,814 | $1,020,082 | | No Change | $1.26 | 13F |
| NMRA | Neumora Therapeutics, Inc. | 0.00710% | 1,034,600 | $758,672 | | No Change | $0.73 | 13F |
| GBIO | Generation Bio Co. | 0.00582% | 1,944,945 | $622,577 | | No Change | $0.32 | 13F |
| ALGS | Aligos Therapeutics, Inc. | 0.00560% | 83,055 | $598,827 | | No Change | $7.21 | 13F |
| TYRA | Tyra Biosciences, Inc. | 0.00095% | 10,607 | $101,509 | | No Change | $9.57 | 13F |
| ACRV | Acrivon Therapeutics, Inc. | 0.00025% | 22,809 | $27,143 | | No Change | $1.19 | 13F |
| SRZNW | Surrozen, Inc. | 0.00014% | 833,333 | $15,083 | | No Change | $0.02 | 13F |
| BCAX | Bicara Therapeutics Inc. | | | | -833,333 | Exited | | 13F |
| CNTA | Centessa Pharmaceuticals plc | | | | -1,227,178 | Exited | | 13F |
| IPSC | Century Therapeutics, Inc. | | | | -241,684 | Exited | | 13F |
| CMPX | Compass Therapeutics, Inc. | | | | -547,498 | Exited | | 13F |
| DYN | Dyne Therapeutics, Inc. | | | | -672,096 | Exited | | 13F |
| IGMS | IGM Biosciences, Inc. | | | | -4,096,210 | Exited | | 13D |
| INSM | Insmed Incorporated (PRN) | | | | -42,850,000 | Exited | | 13F |
| IONS | Ionis Pharmaceuticals, Inc. | | | | -357,915 | Exited | | 13F |
| LPTX | Leap Therapeutics, Inc. | | | | -404,744 | Exited | | 13F |
| OPT | Opthea Limited | | 2,087,320 | | | No Change | | 13F |
| PRME | Prime Medicine, Inc. | | | | -1,028,466 | Exited | | 13F |
| RGLS | Regulus Therapeutics Inc. | | | | -2,694,044 | Exited | | 13F |
| TSVT | 2seventy bio, Inc. | | | | -2,497,526 | Exited | | 13F |
| CRSP | CRISPR Therapeutics AG | | | | -654,099 | Exited | | 13F |
