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| Stock | Company | % Portfolio | Shares Held | Market Value | Change in Shares | % Change | Quarter End Price | Source |
|---|---|---|---|---|---|---|---|---|
| INCY | INCYTE CORP | 24.76% | 36,666,662 | $1,945,533,086 | 486,997 | 1.35% | 13D | |
| BGNE | BeiGene, Ltd. | 20.93% | 10,568,897 | $1,652,869,802 | No Change | $156.39 | 13F | |
| ACAD | ACADIA Pharmaceuticals Inc. | 10.03% | 42,864,612 | $792,566,676 | No Change | $18.49 | 13F | |
| MDGL | Madrigal Pharmaceuticals, Inc. | 6.66% | 1,969,798 | $526,014,858 | No Change | $267.04 | 13F | |
| RYTM | Rhythm Pharmaceuticals, Inc. | 3.51% | 6,398,365 | $277,241,155 | No Change | $43.33 | 13F | |
| RVMD | Revolution Medicines, Inc. | 3.08% | 7,549,249 | $243,312,295 | 2,400,592 | 46.63% | $32.23 | 13F |
| KYMR | Kymera Therapeutics, Inc. | 3.05% | 5,995,928 | $241,036,306 | No Change | $40.2 | 13F | |
| BCYC | BICYCLE THERAPEUTICS plc | 2.13% | 7,689,243 | $168,625,099 | 2,746,420 | 55.56% | 13D | |
| ABCL | AbCellera Biologics Inc. | 1.58% | 27,525,640 | $124,691,149 | 4,615,887 | 20.15% | $4.53 | 13F |
| EWTX | Edgewise Therapeutics, Inc. | 1.35% | 5,840,059 | $106,522,676 | 2,727,273 | 87.62% | $18.24 | 13F |
| IMCR | Immunocore Holdings plc | 1.25% | 1,515,318 | $98,495,670 | -1,005,413 | -39.89% | $65 | 13F |
| KOD | Kodiak Sciences Inc. | 1.15% | 17,310,490 | $91,053,177 | No Change | $5.26 | 13F | |
| REPL | Replimune Group, Inc. | 0.99% | 9,545,336 | $77,985,395 | No Change | $8.17 | 13F | |
| ROIV | Roivant Sciences Ltd. | 0.99% | 7,413,834 | $78,141,810 | -179,190 | -2.36% | $10.54 | 13F |
| DNLI | Denali Therapeutics Inc. | 0.97% | 3,731,695 | $76,574,381 | 1,124,499 | 43.13% | $20.52 | 13F |
| AKRO | Akero Therapeutics, Inc. | 0.87% | 2,713,205 | $68,535,558 | 344,827 | 14.56% | $25.26 | 13F |
| TRDA | Entrada Therapeutics, Inc. | 0.87% | 4,865,819 | $68,948,655 | No Change | $14.17 | 13F | |
| RARE | Ultragenyx Pharmaceutical Inc. | 0.87% | 1,466,547 | $68,473,079 | No Change | $46.69 | 13F | |
| CERE | Cerevel Therapeutics Holdings, Inc. | 0.86% | 1,600,000 | $67,632,000 | No Change | $42.27 | 13F | |
| IMTX | Immatics N.V. | 0.86% | 6,443,398 | $67,720,113 | 604,545 | 10.35% | $10.51 | 13F |
| ARGX | argenx SE | 0.75% | 151,215 | $59,536,370 | No Change | $393.72 | 13F | |
| NRIX | Nurix Therapeutics, Inc. | 0.72% | 3,882,125 | $57,067,238 | No Change | $14.7 | 13F | |
| KNSA | Kiniksa Pharmaceuticals, Ltd. | 0.70% | 2,809,577 | $55,432,954 | No Change | $19.73 | 13F | |
| BCRX | BioCryst Pharmaceuticals, Inc. | 0.65% | 10,126,176 | $51,440,974 | No Change | $5.08 | 13F | |
| AVTE | Aerovate Therapeutics, Inc. | 0.63% | 1,680,517 | $49,692,888 | No Change | $29.57 | 13F | |
| SERA | Sera Prognostics, Inc. | 0.63% | 5,434,399 | $49,453,031 | No Change | $9.1 | 13F | |
| PRLD | Prelude Therapeutics Inc. | 0.61% | 10,123,824 | $47,986,926 | No Change | $4.74 | 13F | |
| IDYA | IDEAYA Biosciences, Inc. | 0.59% | 1,062,123 | $46,605,957 | No Change | $43.88 | 13F | |
| STOK | Stoke Therapeutics, Inc. | 0.58% | 3,368,443 | $45,473,981 | 1,338,309 | 65.92% | $13.5 | 13F |
| XENE | Xenon Pharmaceuticals Inc. | 0.54% | 993,679 | $42,777,881 | No Change | $43.05 | 13F | |
| IGMS | IGM Biosciences, Inc. | 0.50% | 4,088,322 | $39,452,307 | 397,311 | 10.76% | $9.65 | 13F |
| CERS | Cerus Corporation | 0.47% | 19,477,339 | $36,812,171 | No Change | $1.89 | 13F | |
| GLUE | Monte Rosa Therapeutics, Inc. | 0.44% | 4,916,095 | $34,658,470 | No Change | $7.05 | 13F | |
| CELC | Celcuity Inc. | 0.42% | 1,552,478 | $33,533,525 | 1,017,000 | 189.92% | $21.6 | 13F |
| BMEA | Biomea Fusion, Inc. | 0.40% | 2,108,949 | $31,528,788 | No Change | $14.95 | 13F | |
| KRYS | Krystal Biotech, Inc. | 0.38% | 169,934 | $30,236,357 | No Change | $177.93 | 13F | |
| SANA | Sana Biotechnology, Inc. | 0.30% | 2,380,949 | $23,809,490 | 380,949 | 19.05% | $10 | 13F |
| NGNE | Neurogene Inc. | 0.29% | 456,015 | $23,211,164 | 2,499 | 0.55% | $50.9 | 13F |
| VERV | Verve Therapeutics, Inc. | 0.28% | 1,691,530 | $22,463,518 | No Change | $13.28 | 13F | |
| TCRX | TScan Therapeutics, Inc. | 0.25% | 2,828,938 | $19,293,357 | 44,146 | 1.59% | 13D | |
| ADAP | Adaptimmune Therapeutics plc | 0.22% | 10,787,022 | $17,043,495 | -182,260 | -1.66% | $1.58 | 13F |
| FATE | Fate Therapeutics, Inc. | 0.17% | 1,818,181 | $13,345,449 | 1,818,181 | New | $7.34 | 13F |
| IMVT | Immunovant, Inc. | 0.17% | 425,009 | $13,732,041 | No Change | $32.31 | 13F | |
| TSVT | 2seventy bio, Inc. | 0.17% | 2,497,526 | $13,361,764 | No Change | $5.35 | 13F | |
| TSHA | Taysha Gene Therapies, Inc. | 0.15% | 4,004,756 | $11,493,650 | No Change | $2.87 | 13F | |
| XNCR | Xencor, Inc. | 0.15% | 545,431 | $12,070,388 | 300,000 | 122.23% | $22.13 | 13F |
| DBVT | DBV Technologies S.A. | 0.14% | 14,614,264 | $10,947,545 | No Change | $0.75 | 13F | |
| CLDX | Celldex Therapeutics, Inc. | 0.13% | 247,644 | $10,393,619 | No Change | $41.97 | 13F | |
| INSM | Insmed Incorporated | 0.12% | 343,000 | $9,305,590 | No Change | $27.13 | 13F | |
| RLAY | Relay Therapeutics, Inc. | 0.12% | 1,160,117 | $9,628,971 | No Change | $8.3 | 13F | |
| ATHA | Athira Pharma, Inc. | 0.11% | 3,153,807 | $8,641,431 | No Change | $2.74 | 13F | |
| NMRA | Neumora Therapeutics, Inc. | 0.11% | 633,851 | $8,715,451 | 633,851 | New | $13.75 | 13F |
| OPT | Opthea Limited | 0.11% | 2,177,826 | $8,950,865 | -410,819 | -15.87% | $4.11 | 13F |
| DYN | Dyne Therapeutics, Inc. | 0.10% | 285,000 | $8,091,150 | 285,000 | New | $28.39 | 13F |
| PRAX | Praxis Precision Medicines, Inc. | 0.10% | 131,533 | $8,026,144 | 131,533 | New | $61.02 | 13F |
| SAGE | Sage Therapeutics, Inc. | 0.10% | 407,217 | $7,631,247 | 407,217 | New | $18.74 | 13F |
| PRME | Prime Medicine, Inc. | 0.09% | 1,028,466 | $7,199,262 | No Change | $7 | 13F | |
| SGMT | Sagimet Biosciences Inc. | 0.09% | 1,381,898 | $7,489,887 | -74,620 | -5.12% | $5.42 | 13F |
| DSGN | Design Therapeutics, Inc. | 0.08% | 1,662,120 | $6,698,344 | 162,120 | 10.81% | $4.03 | 13F |
| TNGX | Tango Therapeutics, Inc. | 0.08% | 750,000 | $5,955,000 | No Change | $7.94 | 13F | |
| HOOK | HOOKIPA Pharma Inc. | 0.07% | 8,128,151 | $5,787,244 | No Change | $0.71 | 13F | |
| MRSN | Mersana Therapeutics, Inc. | 0.06% | 1,086,115 | $4,865,795 | No Change | $4.48 | 13F | |
| MIRM | Mirum Pharmaceuticals, Inc. | 0.06% | 190,476 | $4,784,757 | No Change | $25.12 | 13F | |
| TLIS | Talis Biomedical Corporation | 0.06% | 508,323 | $4,447,826 | No Change | $8.75 | 13F | |
| ALPN | Alpine Immune Sciences, Inc. | 0.04% | 81,578 | $3,233,752 | 81,578 | New | $39.64 | 13F |
| IPSC | Century Therapeutics, Inc. | 0.04% | 797,460 | $3,333,383 | No Change | $4.18 | 13F | |
| CMPX | Compass Therapeutics, Inc. | 0.04% | 1,557,630 | $3,084,107 | No Change | $1.98 | 13F | |
| FDMT | 4D Molecular Therapeutics, Inc. | 0.04% | 100,000 | $3,186,000 | 100,000 | New | $31.86 | 13F |
| LPTX | Leap Therapeutics, Inc. | 0.04% | 1,172,175 | $3,117,986 | No Change | $2.66 | 13F | |
| PCVX | Vaxcyte, Inc. | 0.04% | 48,885 | $3,339,334 | No Change | $68.31 | 13F | |
| ALGS | Aligos Therapeutics, Inc. | 0.03% | 2,076,400 | $2,034,872 | No Change | $0.98 | 13F | |
| KALA | KALA BIO, Inc. | 0.03% | 266,613 | $2,124,906 | No Change | $7.97 | 13F | |
| VTVT | vTv Therapeutics, Inc. | 0.03% | 97,314 | $2,289,798 | 97,314 | New | $23.53 | 13F |
| ELVN | Enliven Therapeutics, Inc. | 0.03% | 114,833 | $2,019,912 | 114,833 | New | $17.59 | 13F |
| NAMS | NewAmsterdam Pharma Company N.V. | 0.03% | 96,827 | $2,289,959 | 96,827 | New | $23.65 | 13F |
| ACHL | Achilles Therapeutics plc | 0.02% | 1,208,775 | $1,510,969 | -894,017 | -42.52% | $1.25 | 13F |
| GBIO | Generation Bio Co. | 0.02% | 371,219 | $1,510,861 | 371,219 | New | $4.07 | 13F |
| PFE | Pfizer Inc. | 0.01% | 35,000 | $971,250 | No Change | $27.75 | 13F | |
| TARA | Protara Therapeutics, Inc. | 0.01% | 199,671 | $800,681 | No Change | $4.01 | 13F | |
| MURA | Mural Oncology plc | 0.01% | 222,503 | $1,088,040 | 222,503 | New | $4.89 | 13F |
| PMVP | PMV Pharmaceuticals, Inc. | 0.00693% | 322,024 | $547,441 | No Change | $1.7 | 13F | |
| ACRV | Acrivon Therapeutics, Inc. | 0.00479% | 52,885 | $378,128 | 52,885 | New | $7.15 | 13F |
| FHTX | Foghorn Therapeutics Inc. | 0.00383% | 45,027 | $302,131 | No Change | $6.71 | 13F | |
| CABA | Cabaletta Bio, Inc. | 0.00288% | 13,331 | $227,427 | No Change | $17.06 | 13F | |
| CATX | Perspective Therapeutics, Inc. | 0.00226% | 149,787 | $178,247 | -7,489,916 | -98.04% | $1.19 | 13F |
| TYRA | Tyra Biosciences, Inc. | 0.00220% | 10,607 | $173,955 | No Change | $16.4 | 13F | |
| SRZNW | Surrozen, Inc. | 0.00032% | 833,333 | $25,167 | No Change | $0.03 | 13F | |
| AADI | Aadi Bioscience, Inc. | -251,727 | Exited | 13F | ||||
| BCEL | Atreca, Inc. | -2,177,499 | Exited | 13F | ||||
| DAWN | Day One Biopharmaceuticals, Inc. | -1,000,000 | Exited | 13F | ||||
| GRCL | Gracell Biotechnologies Inc. | -2,080,000 | Exited | 13F | ||||
| NVTA | Invitae Corporation | -1,764,546 | Exited | 13F | ||||
| NVTA | Invitae Corporation (PRN) | -300,000,000 | Exited | 13F | ||||
| NVTA | Invitae Corporation (PRN) | -9,274,000 | Exited | 13F | ||||
| MRTX | Mirati Therapeutics, Inc. | -4,121,440 | Exited | 13F | ||||
| PRAX | Praxis Precision Medicines, Inc. | -131,533 | Exited | 13F | ||||
| SPRY | ARS Pharmaceuticals, Inc. | -2,006,451 | Exited | 13F |