| EWTX | EDGEWISE THERAPEUTICS INC | 10.65% | 15,518,492 | $630,516,330 | | No Change | $40.63 | 13F |
| BRVE | Braveheart Bio, Inc. | 6.22% | 12,175,159 | $358,071,426 | 12,175,159 | New | | 13D |
| ELVN | ENLIVEN THERAPEUTICS INC | 5.81% | 6,776,632 | $343,914,074 | -1,182,906 | -14.86% | $50.75 | 13F |
| LLY | ELI LILLY & CO | 5.22% | 257,900 | $309,332,997 | 21,100 | 8.91% | $1199.43 | 13F |
| MBX | MBX Biosciences, Inc. | 3.55% | 3,074,853 | $206,353,385 | -353,883 | -10.32% | | 13D |
| SVA | SINOVAC BIOTECH LTD | 3.12% | 2,718,735 | $184,466,170 | | No Change | $67.85 | 13F |
| AZN | ASTRAZENECA PLC | 2.89% | 915,700 | $171,079,502 | 245,500 | 36.63% | $186.83 | 13F |
| GPCR | STRUCTURE THERAPEUTICS INC | 2.00% | 2,209,400 | $118,578,498 | 733,997 | 49.75% | $53.67 | 13F |
| SION | Sionna Therapeutics, Inc. | 1.87% | 2,469,959 | $110,802,361 | -85,918 | -3.36% | | Form 4 |
| CRVS | CORVUS PHARMACEUTICALS INC | 1.81% | 7,165,006 | $107,045,190 | | No Change | $14.94 | 13F |
| AVBP | ARRIVENT BIOPHARMA INC | 1.78% | 3,027,328 | $105,169,375 | | No Change | $34.74 | 13F |
| GH | GUARDANT HEALTH INC | 1.48% | 583,700 | $87,572,511 | 148,500 | 34.12% | $150.03 | 13F |
| ARGX | ARGENX SE | 1.46% | 92,880 | $86,171,278 | -44,020 | -32.15% | $927.77 | 13F |
| MRK | MERCK & CO INC | 1.44% | 663,400 | $85,246,900 | | No Change | $128.5 | 13F |
| QURE | UNIQURE NV | 1.41% | 1,807,486 | $83,252,805 | -328,663 | -15.39% | $46.06 | 13F |
| PRAX | PRAXIS PRECISION MEDICINES I | 1.30% | 230,100 | $77,035,179 | 57,600 | 33.39% | $334.79 | 13F |
| EW | EDWARDS LIFESCIENCES CORP | 1.28% | 834,900 | $75,525,054 | -395,700 | -32.16% | $90.46 | 13F |
| PRLD | PRELUDE THERAPEUTICS INC | 1.24% | 13,724,571 | $73,151,963 | 2,815,315 | 25.81% | $5.33 | 13F |
| ABVX | ABIVAX SA | 1.23% | 546,522 | $72,829,522 | 80,822 | 17.35% | $133.26 | 13F |
| DYN | DYNE THERAPEUTICS INC | 1.21% | 3,235,684 | $71,864,542 | 317,800 | 10.89% | $22.21 | 13F |
| NTRA | NATERA INC | 1.20% | 262,000 | $71,119,900 | | No Change | $271.45 | 13F |
| CGON | CG ONCOLOGY INC | 1.17% | 972,800 | $69,117,440 | 24,533 | 2.59% | $71.05 | 13F |
| UNH | UNITEDHEALTH GROUP INC | 1.13% | 161,100 | $66,957,993 | 161,100 | New | $415.63 | 13F |
| SPRY | ARS PHARMACEUTICALS INC | 1.12% | 8,288,510 | $66,390,965 | | No Change | $8.01 | 13F |
| COGT | COGENT BIOSCIENCES INC | 1.10% | 1,681,300 | $65,066,310 | 1,359,200 | 421.98% | $38.7 | 13F |
| HUM | HUMANA INC | 1.10% | 164,100 | $65,183,802 | 164,100 | New | $397.22 | 13F |
| ASND | ASCENDIS PHARMA A/S | 1.10% | 244,456 | $65,201,304 | 244,456 | New | $266.72 | 13F |
| BSX | BOSTON SCIENTIFIC CORP | 1.07% | 1,483,200 | $63,302,976 | -898,900 | -37.74% | $42.68 | 13F |
| QTTB | Q32 Bio Inc. | 1.07% | 4,127,987 | $62,786,682 | | No Change | | 13D |
| ISRG | INTUITIVE SURGICAL INC | 1.06% | 157,900 | $62,793,672 | -50,800 | -24.34% | $397.68 | 13F |
| MLYS | MINERALYS THERAPEUTICS INC | 0.96% | 2,110,300 | $56,935,894 | 57,400 | 2.8% | $26.98 | 13F |
| ODTX | ODYSSEY THERAPEUTICS INC | 0.95% | 3,001,198 | $56,152,415 | 3,001,198 | New | $18.71 | 13F |
| XENE | XENON PHARMACEUTICALS INC | 0.91% | 892,471 | $53,869,550 | -167,500 | -15.8% | $60.36 | 13F |
| ARQT | ARCUTIS BIOTHERAPEUTICS INC | 0.90% | 2,042,000 | $53,541,240 | 2,042,000 | New | $26.22 | 13F |
| BMY | BRISTOL-MYERS SQUIBB CO | 0.90% | 925,000 | $53,298,500 | | No Change | $57.62 | 13F |
| SYK | STRYKER CORPORATION | 0.85% | 159,100 | $50,091,044 | -23,400 | -12.82% | $314.84 | 13F |
| CAI | CARIS LIFE SCIENCES INC | 0.84% | 2,806,811 | $50,017,372 | | No Change | $17.82 | 13F |
| XBI | SPDR SERIES TRUST (Put) | 0.80% | 300,000 | $47,475,000 | 300,000 | New | $158.25 | 13F |
| TMO | THERMO FISHER SCIENTIFIC INC | 0.77% | 90,700 | $45,473,352 | 44,200 | 95.05% | $501.36 | 13F |
| ELV | ELEVANCE HEALTH INC FORMERLY | 0.75% | 114,700 | $44,357,931 | | No Change | $386.73 | 13F |
| PVLA | PALVELLA THERAPEUTICS INC NE | 0.75% | 292,360 | $44,678,455 | 157,760 | 117.21% | $152.82 | 13F |
| BLSM | BlossomHill Therapeutics, Inc. | 0.74% | 2,714,279 | $43,428,464 | 2,714,279 | New | | Form 4 |
| STTK | SHATTUCK LABS INC | 0.74% | 6,306,127 | $43,764,521 | | No Change | $6.94 | 13F |
| UPB | UPSTREAM BIO INC | 0.67% | 5,693,589 | $39,399,636 | | No Change | $6.92 | 13F |
| CRNX | CRINETICS PHARMACEUTICALS IN | 0.63% | 999,000 | $37,382,580 | | No Change | $37.42 | 13F |
| RYTM | RHYTHM PHARMACEUTICALS INC | 0.61% | 322,900 | $35,851,587 | 8,800 | 2.8% | $111.03 | 13F |
| FBRX | FORTE BIOSCIENCES INC | 0.57% | 1,577,705 | $33,526,231 | 380,750 | 31.81% | $21.25 | 13F |
| SNDX | SYNDAX PHARMACEUTICALS INC | 0.57% | 1,542,000 | $33,708,120 | 579,700 | 60.24% | $21.86 | 13F |
| CMPX | COMPASS THERAPEUTICS INC | 0.56% | 15,219,994 | $33,331,787 | | No Change | $2.19 | 13F |
| NKTR | NEKTAR THERAPEUTICS | 0.55% | 465,346 | $32,485,804 | 190,346 | 69.22% | $69.81 | 13F |
| KRYS | KRYSTAL BIOTECH INC | 0.52% | 83,200 | $30,922,944 | 14,100 | 20.41% | $371.67 | 13F |
| PRLD | PRELUDE THERAPEUTICS INC | 0.51% | 5,680,186 | $30,275,391 | -530,713 | -8.54% | $5.33 | 13F |
| AXSM | AXSOME THERAPEUTICS INC. | 0.49% | 117,578 | $28,779,567 | -96,343 | -45.04% | $244.77 | 13F |
| ABVX | ABIVAX SA (Call) | 0.45% | 200,000 | $26,652,000 | 200,000 | New | $133.26 | 13F |
| TRVI | TREVI THERAPEUTICS INC | 0.45% | 1,430,293 | $26,674,964 | -1,024,107 | -41.73% | $18.65 | 13F |
| KNSA | KINIKSA PHARMACEUTICALS INTL | 0.45% | 420,600 | $26,897,370 | 240,001 | 132.89% | $63.95 | 13F |
| IRON | DISC MEDICINE INC | 0.44% | 357,535 | $26,150,110 | -710,015 | -66.51% | $73.14 | 13F |
| WST | WEST PHARMACEUTICAL SVSC INC | 0.43% | 70,600 | $25,345,400 | 70,600 | New | $359 | 13F |
| RLMD | RELMADA THERAPEUTICS INC | 0.42% | 3,631,195 | $25,127,869 | -1,084,669 | -23% | $6.92 | 13F |
| STRO | SUTRO BIOPHARMA INC | 0.42% | 743,944 | $24,698,941 | -57,200 | -7.14% | $33.2 | 13F |
| URGN | UROGEN PHARMA LTD | 0.42% | 676,187 | $24,883,682 | -199,300 | -22.76% | $36.8 | 13F |
| SVRA | SAVARA INC | 0.41% | 3,959,900 | $24,392,984 | 3,324,900 | 523.61% | $6.16 | 13F |
| AURA | AURA BIOSCIENCES INC | 0.40% | 3,333,333 | $23,666,664 | 3,333,333 | New | $7.1 | 13F |
| NPCE | NEUROPACE INC | 0.40% | 1,505,125 | $23,916,436 | -591,402 | -28.21% | $15.89 | 13F |
| HELP | CYBIN INC | 0.37% | 3,271,400 | $21,623,954 | -561,443 | -14.65% | $6.61 | 13F |
| ORIC | ORIC PHARMACEUTICALS INC | 0.37% | 2,015,000 | $21,822,450 | -678,929 | -25.2% | $10.83 | 13F |
| SCTX | Scribe Therapeutics, Inc. | 0.34% | 1,348,825 | $20,232,375 | 1,348,825 | New | | Form 4 |
| BCRX | BIOCRYST PHARMACEUTICALS INC | 0.31% | 1,852,000 | $18,520,000 | 426,800 | 29.95% | $10 | 13F |
| BIOA | BIOAGE LABS INC | 0.31% | 752,153 | $18,435,270 | 40,342 | 5.67% | $24.51 | 13F |
| LXEO | LEXEO THERAPEUTICS INC | 0.31% | 3,947,850 | $18,377,242 | 345,400 | 9.59% | $4.66 | 13F |
| PTGX | PROTAGONIST THERAPEUTICS INC (Call) | 0.31% | 150,000 | $18,387,000 | 150,000 | New | $122.58 | 13F |
| WHWK | WHITEHAWK THERAPEUTICS INC | 0.30% | 3,934,296 | $18,019,076 | -231,704 | -5.56% | $4.58 | 13F |
| DFTX | DEFINIUM THERAPEUTICS INC | 0.29% | 365,400 | $17,188,416 | -438,600 | -54.55% | $47.04 | 13F |
| SYRE | SPYRE THERAPEUTICS INC | 0.28% | 186,145 | $16,525,953 | 186,145 | New | $88.78 | 13F |
| CRBP | CORBUS PHARMACEUTICALS HLDGS | 0.28% | 1,737,287 | $16,295,752 | | No Change | $9.38 | 13F |
| VERA | VERA THERAPEUTICS INC | 0.27% | 369,596 | $15,859,364 | | No Change | $42.91 | 13F |
| ALMS | ALUMIS INC | 0.26% | 548,163 | $15,425,307 | | No Change | $28.14 | 13F |
| EYPT | EYEPOINT INC | 0.26% | 1,069,147 | $15,288,802 | | No Change | $14.3 | 13F |
| WAT | WATERS CORP | 0.26% | 40,300 | $15,114,112 | 40,300 | New | $375.04 | 13F |
| MNPR | MONOPAR THERAPEUTICS INC | 0.25% | 157,423 | $14,575,796 | 157,423 | New | $92.59 | 13F |
| TVTX | TRAVERE THERAPEUTICS INC | 0.24% | 253,000 | $14,372,930 | 253,000 | New | $56.81 | 13F |
| TSHA | TAYSHA GENE THERAPIES INC | 0.23% | 2,000,000 | $13,620,000 | 2,000,000 | New | $6.81 | 13F |
| BIIB | BIOGEN INC | 0.22% | 61,600 | $13,309,296 | | No Change | $216.06 | 13F |
| RVMD | REVOLUTION MEDICINES INC | 0.22% | 70,500 | $13,203,240 | 18,500 | 35.58% | $187.28 | 13F |
| DNTH | DIANTHUS THERAPEUTICS INC | 0.19% | 115,000 | $11,210,200 | 115,000 | New | $97.48 | 13F |
| SPRB | SPRUCE BIOSCIENCES INC | 0.18% | 200,000 | $10,800,000 | 200,000 | New | $54 | 13F |
| LFST | LIFESTANCE HEALTH GROUP INC | 0.17% | 947,400 | $10,146,654 | 447,400 | 89.48% | $10.71 | 13F |
| RVMD | REVOLUTION MEDICINES INC (Call) | 0.16% | 50,000 | $9,364,000 | 50,000 | New | $187.28 | 13F |
| ERAS | ERASCA INC | 0.15% | 495,900 | $9,084,888 | 495,900 | New | $18.32 | 13F |
| JANX | JANUX THERAPEUTICS INC | 0.14% | 524,700 | $8,059,392 | -458,900 | -46.66% | $15.36 | 13F |
| KROS | KEROS THERAPEUTICS INC | 0.14% | 759,155 | $8,122,959 | | No Change | $10.7 | 13F |
| TARA | PROTARA THERAPEUTICS INC | 0.14% | 2,220,000 | $8,480,400 | 2,220,000 | New | $3.82 | 13F |
| TECX | TECTONIC THERAPEUTIC INC | 0.13% | 226,600 | $7,789,375 | | No Change | $34.38 | 13F |
| YARW | Yarrow Bioscience, Inc. | 0.13% | 266,306 | $7,605,699 | 266,306 | New | | 13D |
| ACET | ADICET BIO INC | 0.12% | 844,787 | $7,298,960 | -183,157 | -17.82% | $8.64 | 13F |
| PHVS | PHARVARIS N V | 0.12% | 205,400 | $7,102,732 | | No Change | $34.58 | 13F |
| ANRO | ALTO NEUROSCIENCE INC | 0.11% | 257,852 | $6,804,714 | 90,352 | 53.94% | $26.39 | 13F |
| DRUG | BRIGHT MINDS BIOSCIENCES INC | 0.11% | 93,000 | $6,528,600 | 53,000 | 132.5% | $70.2 | 13F |
| ZNTL | ZENTALIS PHARMACEUTICALS INC | 0.11% | 1,390,576 | $6,744,294 | 1,390,576 | New | $4.85 | 13F |
| ALXO | ALX ONCOLOGY HLDGS INC | 0.10% | 2,866,256 | $5,933,150 | | No Change | $2.07 | 13F |
| BCAX | BICARA THERAPEUTICS INC | 0.10% | 191,100 | $5,673,759 | -476,200 | -71.36% | $29.69 | 13F |
| PVLA | PALVELLA THERAPEUTICS INC NE (Call) | 0.10% | 40,000 | $6,112,800 | -10,000 | -20% | $152.82 | 13F |
| TVTX | TRAVERE THERAPEUTICS INC (PRN) | 0.10% | 5,000,000 | $5,894,350 | 5,000,000 | New | $1.18 | 13F |
| XLO | XILIO THERAPEUTICS INC | 0.10% | 592,300 | $5,674,234 | 592,300 | New | $9.58 | 13F |
| ALNY | ALNYLAM PHARMACEUTICALS INC | 0.09% | 17,000 | $5,117,510 | -102,000 | -85.71% | $301.03 | 13F |
| IMA | IMAGENEBIO INC | 0.09% | 909,269 | $5,364,687 | 530,713 | 140.19% | $5.9 | 13F |
| PTGX | PROTAGONIST THERAPEUTICS INC | 0.09% | 42,100 | $5,160,618 | | No Change | $122.58 | 13F |
| PALI | PALISADE BIO INC | 0.08% | 2,333,000 | $4,875,970 | | No Change | $2.09 | 13F |
| ELV | ELEVANCE HEALTH INC FORMERLY (Call) | 0.07% | 10,000 | $3,867,300 | 10,000 | New | $386.73 | 13F |
| ATAI | ATAIBECKLEY INC | 0.07% | 797,500 | $4,202,825 | 450,500 | 129.83% | $5.27 | 13F |
| AORT | ARTIVION INC | 0.07% | 175,000 | $3,932,250 | 24,000 | 15.89% | $22.47 | 13F |
| PTCT | PTC THERAPEUTICS INC | 0.07% | 49,100 | $4,005,087 | | No Change | $81.57 | 13F |
| RVMD | REVOLUTION MEDICINES INC (PRN) | 0.07% | 3,500,000 | $4,379,725 | 3,500,000 | New | $1.25 | 13F |
| UNH | UNITEDHEALTH GROUP INC (Call) | 0.07% | 10,000 | $4,156,300 | 10,000 | New | $415.63 | 13F |
| ACAD | ACADIA PHARMACEUTICALS INC | 0.06% | 137,000 | $3,466,100 | 137,000 | New | $25.3 | 13F |
| AMLX | AMYLYX PHARMACEUTICALS INC | 0.06% | 183,400 | $3,293,864 | 183,400 | New | $17.96 | 13F |
| NMRA | NEUMORA THERAPEUTICS INC. | 0.06% | 2,139,882 | $3,637,799 | 2,139,882 | New | $1.7 | 13F |
| TYRA | TYRA BIOSCIENCES INC | 0.06% | 102,000 | $3,257,880 | 102,000 | New | $31.94 | 13F |
| RAPP | RAPPORT THERAPEUTICS INC | 0.05% | 76,616 | $3,192,589 | 76,616 | New | $41.67 | 13F |
| ACRS | ACLARIS THERAPEUTICS INC | 0.04% | 421,500 | $2,229,735 | 421,500 | New | $5.29 | 13F |
| AGMB | AGOMAB THERAPEUTICS NV | 0.04% | 192,740 | $2,501,765 | 192,740 | New | $12.98 | 13F |
| CYTK | CYTOKINETICS INC | 0.04% | 25,800 | $2,197,902 | 25,800 | New | $85.19 | 13F |
| EVMN | EVOMMUNE INC | 0.04% | 161,000 | $2,139,690 | 161,000 | New | $13.29 | 13F |
| NSPR | INSPIREMD INC | 0.04% | 3,133,405 | $2,193,697 | | No Change | $0.7 | 13F |
| OCUL | OCULAR THERAPEUTIX INC | 0.04% | 220,000 | $2,160,400 | 220,000 | New | $9.82 | 13F |
| TARS | TARSUS PHARMACEUTICALS INC | 0.04% | 35,581 | $2,239,468 | 35,581 | New | $62.94 | 13F |
| BLTE | BELITE BIO INC | 0.03% | 13,300 | $2,048,001 | 13,300 | New | $153.99 | 13F |
| EPRX | EUPRAXIA PHARMACEUTICALS INC | 0.03% | 269,000 | $1,778,090 | 269,000 | New | $6.61 | 13F |
| OVID | OVID THERAPEUTICS INC | 0.03% | 747,000 | $2,009,430 | 747,000 | New | $2.69 | 13F |
| COGT | COGENT BIOSCIENCES INC (PRN) | 0.02% | 1,000,000 | $1,227,500 | | No Change | $1.23 | 13F |
| TRAW | TRAWS PHARMA INC | 0.02% | 1,203,260 | $1,014,709 | 597,729 | 98.71% | $0.84 | 13F |
| SLS | SELLAS LIFE SCIENCES GROUP I (Put) | 0.02% | 92,500 | $1,365,300 | 92,500 | New | $14.76 | 13F |
| VRDN | VIRIDIAN THERAPEUTICS INC (PRN) | 0.02% | 1,000,000 | $1,072,670 | 1,000,000 | New | $1.07 | 13F |
| JBIO | JADE BIOSCIENCES INC | | | | -185,011 | Exited | | 13F |
| ALHC | ALIGNMENT HEALTHCARE INC | | | | -791,000 | Exited | | 13F |
| AMGN | AMGEN INC | | | | -39,900 | Exited | | 13F |
| ASND | ASCENDIS PHARMA A/S | | | | -181,977 | Exited | | 13F |
| AVTX | AVALO THERAPEUTICS INC | | | | -475,165 | Exited | | 13F |
| RCEL | AVITA MEDICAL INC (PRN) | | | | -40,500,000 | Exited | | 13F |
| RCEL | AVITA MEDICAL INC | | | | -544,895 | Exited | | 13F |
| RCEL | AVITA MEDICAL INC (Call) | | | | -40,966,100 | Exited | | 13F |
| BTSG | BRIGHTSPRING HEALTH SVCS INC | | | | -497,800 | Exited | | 13F |
| CCCC | C4 THERAPEUTICS INC | | | | -856,353 | Exited | | 13F |
| CARL | CARLSMED INC | | | | -1,252,600 | Exited | | 13F |
| CMPS | COMPASS PATHWAYS PLC | | | | -1,150,646 | Exited | | 13F |
| CGEM | CULLINAN THERAPEUTICS INC | | | | -243,006 | Exited | | 13F |
| DHR | DANAHER CORP DEL | | | | -265,800 | Exited | | 13F |
| ESPR | ESPERION THERAPEUTICS INC NE | | | | -10,570,300 | Exited | | 13F |
| GILD | GILEAD SCIENCES INC | | | | -59,600 | Exited | | 13F |
| HRTX | HERON THERAPEUTICS INC | | | | -9,816,940 | Exited | | 13F |
| KALV | KALVISTA PHARMACEUTICALS INC | | | | -94,400 | Exited | | 13F |
| MYGN | MYRIAD GENETICS INC (PRN) | | | | -125,000,000 | Exited | | 13F |
| PFE | PFIZER INC | | | | -1,946,500 | Exited | | 13F |
| REGN | REGENERON PHARMACEUTICALS | | | | -14,700 | Exited | | 13F |
| SLNO | SOLENO THERAPEUTICS INC (Call) | | | | -100,000 | Exited | | 13F |
| VTGN | VISTAGEN THERAPEUTICS INC | | | | -3,060,000 | Exited | | 13F |
| MDXH | MDXHEALTH SA (Call) | | | | -124,306,000 | Exited | | 13F |
| ADCT | ADC THERAPEUTICS SA | | | | -1,318,026 | Exited | | 13F |
| QGEN | QIAGEN NV (Call) | | | | -250,000 | Exited | | 13F |
