| EWTX | EDGEWISE THERAPEUTICS INC | 5.83% | 15,518,492 | $251,709,940 | | No Change | $16.22 | 13F |
| BSX | BOSTON SCIENTIFIC CORP | 5.50% | 2,429,300 | $237,172,559 | -383,900 | -13.65% | $97.63 | 13F |
| LLY | ELI LILLY & CO | 5.33% | 301,200 | $229,815,600 | -36,400 | -10.78% | $763 | 13F |
| SVA | SINOVAC BIOTECH LTD | 4.28% | 2,718,735 | $184,466,170 | | No Change | $67.85 | 13F |
| ELVN | ENLIVEN THERAPEUTICS INC | 3.78% | 7,959,538 | $162,931,743 | | No Change | $20.47 | 13F |
| SION | Sionna Therapeutics, Inc. | 3.71% | 3,596,886 | $160,025,458 | -108,073 | -2.92% | | Form 4 |
| ALNY | ALNYLAM PHARMACEUTICALS INC | 3.19% | 301,600 | $137,529,600 | -40,300 | -11.79% | $456 | 13F |
| SYK | STRYKER CORPORATION | 3.08% | 359,200 | $132,785,464 | | No Change | $369.67 | 13F |
| EW | EDWARDS LIFESCIENCES CORP | 3.04% | 1,684,000 | $130,964,680 | -24,000 | -1.41% | $77.77 | 13F |
| ISRG | INTUITIVE SURGICAL INC | 2.98% | 287,200 | $128,444,456 | -3,800 | -1.31% | $447.23 | 13F |
| ARGX | ARGENX SE | 2.95% | 172,300 | $127,081,588 | -35,700 | -17.16% | $737.56 | 13F |
| UPB | UPSTREAM BIO INC | 2.48% | 5,693,589 | $107,096,409 | | No Change | $18.81 | 13F |
| IRON | DISC MEDICINE INC | 2.17% | 1,415,020 | $93,504,522 | | No Change | $66.08 | 13F |
| CAI | CARIS LIFE SCIENCES INC | 2.13% | 3,034,858 | $91,804,455 | | No Change | $30.25 | 13F |
| SPRY | ARS PHARMACEUTICALS INC | 1.93% | 8,288,510 | $83,299,526 | | No Change | $10.05 | 13F |
| RNA | AVIDITY BIOSCIENCES INC | 1.65% | 1,638,886 | $71,406,263 | -174,000 | -9.6% | $43.57 | 13F |
| MBX | MBX BIOSCIENCES INC | 1.62% | 4,002,887 | $70,050,523 | | No Change | $17.5 | 13F |
| CGON | CG ONCOLOGY INC | 1.61% | 1,726,850 | $69,557,518 | -151,000 | -8.04% | $40.28 | 13F |
| NTRA | NATERA INC | 1.60% | 429,300 | $69,104,421 | -164,134 | -27.66% | $160.97 | 13F |
| AXSM | AXSOME THERAPEUTICS INC | 1.50% | 531,800 | $64,587,110 | 103,900 | 24.28% | $121.45 | 13F |
| TERN | Terns Pharmaceuticals, Inc. | 1.40% | 4,240,068 | $59,488,154 | -3,322,903 | -43.94% | | 13D |
| AVBP | ARRIVENT BIOPHARMA INC | 1.29% | 3,027,328 | $55,854,202 | | No Change | $18.45 | 13F |
| MLYS | MINERALYS THERAPEUTICS INC | 1.29% | 1,469,494 | $55,723,212 | 709,143 | 93.27% | $37.92 | 13F |
| EXAS | EXACT SCIENCES CORP | 1.26% | 994,616 | $54,415,441 | 387,300 | 63.77% | $54.71 | 13F |
| CMPX | COMPASS THERAPEUTICS INC | 1.23% | 15,219,994 | $53,269,979 | | No Change | $3.5 | 13F |
| APLS | APELLIS PHARMACEUTICALS INC | 1.22% | 2,323,368 | $52,577,818 | 841,068 | 56.74% | $22.63 | 13F |
| CRVS | CORVUS PHARMACEUTICALS INC | 1.22% | 7,165,006 | $52,806,094 | | No Change | $7.37 | 13F |
| DHR | DANAHER CORPORATION | 1.21% | 263,100 | $52,162,206 | 263,100 | New | $198.26 | 13F |
| NBIX | NEUROCRINE BIOSCIENCES INC | 1.15% | 353,640 | $49,643,983 | -84,900 | -19.36% | $140.38 | 13F |
| UTHR | UNITED THERAPEUTICS CORP DEL | 1.12% | 114,900 | $48,167,229 | 114,900 | New | $419.21 | 13F |
| CI | THE CIGNA GROUP | 1.09% | 162,800 | $46,927,100 | 162,800 | New | $288.25 | 13F |
| CRNX | CRINETICS PHARMACEUTICALS IN | 1.06% | 1,099,000 | $45,773,350 | -50,000 | -4.35% | $41.65 | 13F |
| ORIC | ORIC PHARMACEUTICALS INC | 1.01% | 3,641,756 | $43,701,072 | 2,742,475 | 304.96% | $12 | 13F |
| JANX | JANUX THERAPEUTICS INC | 1.00% | 1,766,100 | $43,163,484 | 555,800 | 45.92% | $24.44 | 13F |
| ROIV | ROIVANT SCIENCES LTD | 0.95% | 2,714,798 | $41,074,894 | -64,629 | -2.33% | $15.13 | 13F |
| ASND | ASCENDIS PHARMA A/S | 0.88% | 191,905 | $38,152,633 | 157,505 | 457.86% | $198.81 | 13F |
| SIBN | SI-BONE INC | 0.88% | 2,578,979 | $37,962,571 | | No Change | $14.72 | 13F |
| SCPH | SCPHARMACEUTICALS INC | 0.80% | 6,059,528 | $34,357,524 | | No Change | $5.67 | 13F |
| ABVX | ABIVAX SA | 0.75% | 380,000 | $32,262,000 | 380,000 | New | $84.9 | 13F |
| GPCR | STRUCTURE THERAPEUTICS INC | 0.74% | 1,139,300 | $31,900,400 | -60,000 | -5% | $28 | 13F |
| TRVI | TREVI THERAPEUTICS INC | 0.70% | 3,308,400 | $30,271,860 | | No Change | $9.15 | 13F |
| ITGR | INTEGER HLDGS CORP | 0.69% | 290,000 | $29,965,700 | -143,400 | -33.09% | $103.33 | 13F |
| DYN | DYNE THERAPEUTICS INC | 0.68% | 2,314,184 | $29,274,428 | 1,282,784 | 124.37% | $12.65 | 13F |
| RAPT | RAPT THERAPEUTICS INC | 0.65% | 1,086,618 | $28,023,878 | -555,288 | -33.82% | $25.79 | 13F |
| CTMX | CYTOMX THERAPEUTICS INC | 0.63% | 8,461,500 | $26,992,185 | | No Change | $3.19 | 13F |
| NPCE | NEUROPACE INC | 0.62% | 2,614,184 | $26,952,237 | | No Change | $10.31 | 13F |
| QURE | UNIQURE NV | 0.62% | 458,500 | $26,762,645 | 458,500 | New | $58.37 | 13F |
| EYPT | EYEPOINT PHARMACEUTICALS INC | 0.59% | 1,796,000 | $25,575,040 | 1,796,000 | New | $14.24 | 13F |
| AKRO | AKERO THERAPEUTICS INC | 0.58% | 526,200 | $24,983,976 | 314,900 | 149.03% | $47.48 | 13F |
| ADCT | ADC THERAPEUTICS SA | 0.55% | 5,907,351 | $23,629,404 | | No Change | $4 | 13F |
| TMO | THERMO FISHER SCIENTIFIC INC | 0.52% | 46,500 | $22,553,430 | | No Change | $485.02 | 13F |
| RYTM | RHYTHM PHARMACEUTICALS INC | 0.50% | 215,152 | $21,728,200 | -33,360 | -13.42% | $100.99 | 13F |
| ABT | ABBOTT LABS (Call) | 0.47% | 150,000 | $20,091,000 | 150,000 | New | $133.94 | 13F |
| BSX | BOSTON SCIENTIFIC CORP (Call) | 0.45% | 200,000 | $19,526,000 | 200,000 | New | $97.63 | 13F |
| FBRX | FORTE BIOSCIENCES INC | 0.42% | 1,196,955 | $17,954,325 | | No Change | $15 | 13F |
| KRYS | KRYSTAL BIOTECH INC | 0.42% | 102,745 | $18,137,575 | 93,545 | 1016.79% | $176.53 | 13F |
| AVTX | AVALO THERAPEUTICS INC | 0.40% | 1,349,300 | $17,149,603 | 382,300 | 39.53% | $12.71 | 13F |
| CARL | CARLSMED INC | 0.39% | 1,252,600 | $16,772,314 | 1,252,600 | New | $13.39 | 13F |
| XENE | XENON PHARMACEUTICALS INC | 0.39% | 419,600 | $16,846,940 | -528,277 | -55.73% | $40.15 | 13F |
| KROS | KEROS THERAPEUTICS INC | 0.37% | 1,018,734 | $16,116,372 | | No Change | $15.82 | 13F |
| PRLD | PRELUDE THERAPEUTICS INC | 0.36% | 10,909,256 | $15,709,329 | | No Change | $1.44 | 13F |
| STTK | SHATTUCK LABS INC | 0.35% | 6,306,127 | $15,071,644 | 6,306,127 | New | $2.39 | 13F |
| CRBP | CORBUS PHARMACEUTICALS HLDGS | 0.34% | 1,172,287 | $14,829,431 | | No Change | $12.65 | 13F |
| VIR | VIR BIOTECHNOLOGY INC | 0.32% | 2,380,715 | $13,593,883 | | No Change | $5.71 | 13F |
| URGN | UROGEN PHARMA LTD | 0.32% | 689,000 | $13,745,550 | 210,600 | 44.02% | $19.95 | 13F |
| FOLD | AMICUS THERAPEUTICS INC | 0.30% | 1,645,400 | $12,965,752 | -640,000 | -28% | $7.88 | 13F |
| PFE | PFIZER INC (Call) | 0.30% | 500,000 | $12,740,000 | 500,000 | New | $25.48 | 13F |
| IMA | IMAGENEBIO INC | 0.29% | 6,210,899 | $12,504,779 | -5,837,874 | -48.45% | $2.01 | 13F |
| ACET | Adicet Bio, Inc. | 0.28% | 11,956,886 | $11,956,886 | 509,746 | 4.45% | | Form 4 |
| AZN | ASTRAZENECA PLC (Call) | 0.27% | 150,000 | $11,508,000 | 50,000 | 50% | $76.72 | 13F |
| CCCC | C4 THERAPEUTICS INC | 0.27% | 5,235,146 | $11,622,024 | -1,595,154 | -23.35% | $2.22 | 13F |
| TARS | TARSUS PHARMACEUTICALS INC | 0.27% | 197,900 | $11,761,197 | | No Change | $59.43 | 13F |
| CGEM | CULLINAN THERAPEUTICS INC | 0.26% | 1,923,855 | $11,408,460 | | No Change | $5.93 | 13F |
| VTGN | VISTAGEN THERAPEUTICS INC | 0.25% | 3,060,000 | $10,863,000 | 3,060,000 | New | $3.55 | 13F |
| AMLX | AMYLYX PHARMACEUTICALS INC | 0.24% | 750,600 | $10,200,654 | 437,400 | 139.66% | $13.59 | 13F |
| WHWK | WHITEHAWK THERAPEUTICS INC | 0.18% | 4,166,000 | $7,915,400 | | No Change | $1.9 | 13F |
| ALMS | ALUMIS INC | 0.18% | 1,926,423 | $7,686,428 | | No Change | $3.99 | 13F |
| BTSG | BRIGHTSPRING HEALTH SVCS INC | 0.18% | 263,800 | $7,797,928 | 263,800 | New | $29.56 | 13F |
| PMVP | PMV Pharmaceuticals, Inc. | 0.18% | 4,975,291 | $7,562,442 | -1,000,000 | -16.74% | | Form 4 |
| VSTM | VERASTEM INC | 0.18% | 887,561 | $7,837,164 | 887,561 | New | $8.83 | 13F |
| BCRX | BIOCRYST PHARMACEUTICALS INC | 0.16% | 901,500 | $6,842,385 | 901,500 | New | $7.59 | 13F |
| MIST | MILESTONE PHARMACEUTICALS IN | 0.15% | 3,221,828 | $6,443,656 | 3,221,828 | New | $2 | 13F |
| RPTX | REPARE THERAPEUTICS INC | 0.14% | 3,322,488 | $5,847,579 | | No Change | $1.76 | 13F |
| APLS | APELLIS PHARMACEUTICALS INC (Call) | 0.13% | 250,000 | $5,657,500 | 200,000 | 400% | $22.63 | 13F |
| NSPR | INSPIREMD INC | 0.12% | 2,133,405 | $5,141,506 | | No Change | $2.41 | 13F |
| JBIO | JADE BIOSCIENCES INC | 0.11% | 531,163 | $4,583,937 | | No Change | $8.63 | 13F |
| BIOA | BIOAGE LABS INC | 0.11% | 790,901 | $4,650,498 | -131,058 | -14.22% | $5.88 | 13F |
| BTSG | BRIGHTSPRING HEALTH SVCS INC (Call) | 0.10% | 150,000 | $4,434,000 | 150,000 | New | $29.56 | 13F |
| CELC | CELCUITY INC | 0.10% | 84,020 | $4,150,588 | 84,020 | New | $49.4 | 13F |
| CRNX | CRINETICS PHARMACEUTICALS IN (Put) | 0.10% | 100,000 | $4,165,000 | 100,000 | New | $41.65 | 13F |
| MNMD | MIND MEDICINE MINDMED INC | 0.10% | 367,824 | $4,336,645 | 367,824 | New | $11.79 | 13F |
| QTTB | Q32 BIO INC | 0.10% | 2,252,987 | $4,460,914 | | No Change | $1.98 | 13F |
| SRRK | SCHOLAR ROCK HLDG CORP (Call) | 0.09% | 100,000 | $3,724,000 | 100,000 | New | $37.24 | 13F |
| IMTX | IMMATICS N.V | 0.09% | 466,601 | $3,975,441 | -253,300 | -35.19% | $8.52 | 13F |
| TGTX | TG THERAPEUTICS INC (Call) | 0.08% | 100,000 | $3,612,500 | 100,000 | New | $36.13 | 13F |
| IMA | IMAGENEBIO INC | 0.07% | 378,556 | $3,085,231 | 378,556 | New | $8.15 | 13F |
| CELC | CELCUITY INC (PRN) | 0.06% | 2,000,000 | $2,684,240 | 2,000,000 | New | $1.34 | 13F |
| INSM | INSMED INC | 0.04% | 13,459 | $1,938,231 | | No Change | $144.01 | 13F |
| KRRO | KORRO BIO INC | 0.04% | 32,400 | $1,551,636 | | No Change | $47.89 | 13F |
| ATAI | ATAI LIFE SCIENCES NV | 0.04% | 347,000 | $1,835,630 | 347,000 | New | $5.29 | 13F |
| TRAW | TRAWS PHARMA INC | 0.03% | 605,531 | $1,120,232 | | No Change | $1.85 | 13F |
| MURA | MURAL ONCOLOGY PUB LTD CO | 0.03% | 588,800 | $1,218,816 | | No Change | $2.07 | 13F |
| ANRO | ALTO NEUROSCIENCE INC | 0.02% | 250,000 | $1,005,000 | | No Change | $4.02 | 13F |
| KZR | KEZAR LIFE SCIENCES INC | 0.02% | 192,700 | $751,530 | | No Change | $3.9 | 13F |
| LYEL | LYELL IMMUNOPHARMA INC | 0.02% | 51,727 | $840,046 | | No Change | $16.24 | 13F |
| XERS | XERIS BIOPHARMA HOLDINGS INC | 0.02% | 80,420 | $654,619 | | No Change | $8.14 | 13F |
| PASG | PASSAGE BIO INC | 0.01% | 59,046 | $474,139 | 59,046 | New | $8.03 | 13F |
| DHAI | DIH HLDG US INC | 0.00830% | 1,915,000 | $358,105 | | No Change | $0.19 | 13F |
| VTGN | VISTAGEN THERAPEUTICS INC (Call) | 0.00372% | 45,200 | $160,460 | 45,200 | New | $3.55 | 13F |
| ABCL | ABCELLERA BIOLOGICS INC | | | | -3,344,568 | Exited | | 13F |
| AGIO | AGIOS PHARMACEUTICALS INC | | | | -557,900 | Exited | | 13F |
| CPRX | CATALYST PHARMACEUTICALS INC | | | | -416,900 | Exited | | 13F |
| CGON | CG ONCOLOGY INC (Call) | | | | -150,000 | Exited | | 13F |
| CMMB | CHEMOMAB THERAPEUTICS LTD | | | | -940,990 | Exited | | 13F |
| CYTK | CYTOKINETICS INC | | | | -1,077,000 | Exited | | 13F |
| ENGN | ENGENE HOLDINGS INC | | | | -677,977 | Exited | | 13F |
| IKNA | IKENA ONCOLOGY INC | | | | -3,539,358 | Exited | | 13F |
| INMB | INMUNE BIO INC (Put) | | | | -50,000 | Exited | | 13F |
| ITOS | ITEOS THERAPEUTICS INC | | | | -700,000 | Exited | | 13F |
| PASG | PASSAGE BIO INC | | | | -6,055,300 | Exited | | 13F |
| THC | TENET HEALTHCARE CORP | | | | -465,000 | Exited | | 13F |
| THRD | THIRD HARMONIC BIO INC | | | | -5,779,071 | Exited | | 13F |
| TSBX | TURNSTONE BIOLOGICS CORP | | | | -3,099,265 | Exited | | 13F |
| TYRA | TYRA BIOSCIENCES INC | | | | -804,603 | Exited | | 13F |
| UNH | UNITEDHEALTH GROUP INC | | | | -336,300 | Exited | | 13F |
| UNH | UNITEDHEALTH GROUP INC (Call) | | | | -50,000 | Exited | | 13F |
| VRTX | VERTEX PHARMACEUTICALS INC | | | | -210,287 | Exited | | 13F |
| ZLAB | ZAI LAB LTD | | | | -231,000 | Exited | | 13F |
| LSB | LAKESHORE BIOPHARMA CO LTD | | | | -54,799 | Exited | | 13F |
