SVA | SINOVAC BIOTECH LTD | 6.45% | 2,718,735 | $340,000,000 | | No Change | $125.06 | 13F |
BIIB | BIOGEN INC | 4.06% | 827,600 | $214,158,052 | 270,800 | 48.64% | $258.77 | 13F |
LLY | ELI LILLY & CO | 4.04% | 365,400 | $212,998,968 | 179,400 | 96.45% | $582.92 | 13F |
BSX | BOSTON SCIENTIFIC CORP | 3.62% | 3,306,800 | $191,166,108 | | No Change | $57.81 | 13F |
ELVN | Enliven Therapeutics, Inc. | 3.33% | 8,951,463 | $168,287,504 | -46,875 | -0.52% | | 13D |
ISRG | INTUITIVE SURGICAL INC | 3.19% | 499,000 | $168,342,640 | | No Change | $337.36 | 13F |
EWTX | Edgewise Therapeutics, Inc. | 3.08% | 14,756,096 | $162,317,056 | 188,920 | 1.30% | | Form 4 |
BMRN | BIOMARIN PHARMACEUTICAL INC | 2.87% | 1,571,410 | $151,515,352 | -43,800 | -2.71% | $96.42 | 13F |
RYZB | RAYZEBIO INC | 2.79% | 2,365,213 | $147,045,292 | -257,696 | -9.82% | $62.17 | 13F |
SWTX | SPRINGWORKS THERAPEUTICS INC | 2.23% | 3,219,359 | $117,506,604 | -749,229 | -18.88% | $36.5 | 13F |
MRK | MERCK & CO INC | 2.18% | 1,055,000 | $115,016,100 | | No Change | $109.02 | 13F |
IONS | IONIS PHARMACEUTICALS INC | 1.98% | 2,064,797 | $104,458,080 | -104,703 | -4.83% | $50.59 | 13F |
IRON | DISC MEDICINE INC | 1.86% | 1,702,237 | $98,321,209 | -567,400 | -25% | $57.76 | 13F |
GRCL | GRACELL BIOTECHNOLOGIES INC | 1.77% | 9,308,726 | $93,459,609 | | No Change | $10.04 | 13F |
THC | TENET HEALTHCARE CORP | 1.75% | 1,224,400 | $92,527,908 | | No Change | $75.57 | 13F |
EVH | EVOLENT HEALTH INC | 1.72% | 2,746,532 | $90,717,952 | -149,100 | -5.15% | $33.03 | 13F |
UTHR | UNITED THERAPEUTICS CORP DEL | 1.61% | 386,100 | $84,899,529 | -15,800 | -3.93% | $219.89 | 13F |
XTNT | XTANT MED HLDGS INC | 1.57% | 73,114,592 | $82,619,489 | | No Change | $1.13 | 13F |
SYK | STRYKER CORPORATION | 1.53% | 269,000 | $80,554,740 | | No Change | $299.46 | 13F |
SRRK | SCHOLAR ROCK HLDG CORP | 1.51% | 4,245,000 | $79,806,000 | 2,211,211 | 108.72% | $18.8 | 13F |
TMO | THERMO FISHER SCIENTIFIC INC | 1.45% | 143,800 | $76,327,602 | | No Change | $530.79 | 13F |
VRNA | VERONA PHARMA PLC | 1.42% | 3,777,778 | $75,102,227 | | No Change | $19.88 | 13F |
PCVX | VAXCYTE INC | 1.37% | 1,153,091 | $72,414,115 | 145,943 | 14.49% | $62.8 | 13F |
THRX | THESEUS PHARMACEUTICALS INC | 1.36% | 17,713,600 | $71,740,080 | | No Change | $4.05 | 13F |
VRTX | VERTEX PHARMACEUTICALS INC | 1.35% | 175,200 | $71,287,128 | 9,800 | 5.93% | $406.89 | 13F |
NBIX | NEUROCRINE BIOSCIENCES INC | 1.30% | 519,279 | $68,420,201 | 103,379 | 24.86% | $131.76 | 13F |
SRPT | SAREPTA THERAPEUTICS INC | 1.28% | 697,500 | $67,259,925 | 168,300 | 31.8% | $96.43 | 13F |
ELV | ELEVANCE HEALTH INC | 1.26% | 141,500 | $66,725,740 | 141,500 | New | $471.56 | 13F |
THRD | THIRD HARMONIC BIO INC | 1.20% | 5,779,071 | $63,396,409 | | No Change | $10.97 | 13F |
NTRA | NATERA INC | 1.13% | 954,481 | $59,788,690 | 33,900 | 3.68% | $62.64 | 13F |
CRNX | CRINETICS PHARMACEUTICALS IN | 1.12% | 1,667,360 | $59,324,669 | -1,228,714 | -42.43% | $35.58 | 13F |
APLS | APELLIS PHARMACEUTICALS INC | 1.05% | 922,200 | $55,202,892 | -338,300 | -26.84% | $59.86 | 13F |
NPCE | NeuroPace Inc | 0.97% | 3,518,967 | $50,743,504 | -485,000 | -12.11% | | Form 4 |
KROS | KEROS THERAPEUTICS INC | 0.96% | 1,268,734 | $50,444,864 | -246,000 | -16.24% | $39.76 | 13F |
RCM | R1 RCM INC | 0.96% | 4,803,200 | $50,769,824 | 1,362,200 | 39.59% | $10.57 | 13F |
SPRY | ARS PHARMACEUTICALS INC | 0.96% | 9,240,887 | $50,640,061 | | No Change | $5.48 | 13F |
HUM | HUMANA INC | 0.95% | 109,900 | $50,313,319 | -232,600 | -67.91% | $457.81 | 13F |
TERN | TERNS PHARMACEUTICALS INC | 0.94% | 7,619,135 | $49,448,186 | | No Change | $6.49 | 13F |
ALPN | ALPINE IMMUNE SCIENCES INC | 0.92% | 2,535,245 | $48,321,770 | -1,546,347 | -37.89% | $19.06 | 13F |
SIBN | SI-BONE INC | 0.91% | 2,292,531 | $48,120,226 | | No Change | $20.99 | 13F |
PRLD | PRELUDE THERAPEUTICS INC | 0.88% | 10,909,256 | $46,582,523 | | No Change | $4.27 | 13F |
ALXO | ALX ONCOLOGY HLDGS INC | 0.87% | 3,095,000 | $46,084,550 | 224,000 | 7.8% | $14.89 | 13F |
CMPX | Compass Therapeutics, Inc. | 0.83% | 18,791,422 | $42,092,785 | -3,571,428 | -15.97% | | 13D |
QTTB | Q32 Bio Inc. | 0.74% | 2,252,987 | $37,512,234 | 2,252,987 | New | | 13D |
IOVA | IOVANCE BIOTHERAPEUTICS INC | 0.73% | 4,707,458 | $38,271,634 | | No Change | $8.13 | 13F |
SNDX | SYNDAX PHARMACEUTICALS INC | 0.72% | 1,749,000 | $37,795,890 | 465,000 | 36.21% | $21.61 | 13F |
ICLR | ICON PLC | 0.71% | 132,200 | $37,421,854 | | No Change | $283.07 | 13F |
IKNA | IKENA ONCOLOGY INC | 0.70% | 12,048,773 | $36,800,510 | | No Change | $3.05 | 13F |
AMGN | AMGEN INC | 0.70% | 127,300 | $36,664,946 | | No Change | $288.02 | 13F |
UNH | UNITEDHEALTH GROUP INC | 0.70% | 70,000 | $36,852,900 | | No Change | $526.47 | 13F |
APGE | APOGEE THERAPEUTICS INC | 0.68% | 1,277,901 | $35,704,554 | -150,000 | -10.5% | $27.94 | 13F |
JANX | JANUX THERAPEUTICS INC | 0.67% | 3,317,927 | $35,601,357 | | No Change | $10.73 | 13F |
SCPH | SCPHARMACEUTICALS INC | 0.66% | 5,559,528 | $34,858,241 | | No Change | $6.27 | 13F |
ARGX | ARGENX SE | 0.61% | 84,600 | $32,184,378 | 52,000 | 159.51% | $380.43 | 13F |
SLRN | ACELYRIN INC | 0.57% | 4,001,711 | $29,852,764 | -1,324,591 | -24.87% | $7.46 | 13F |
FUSN | FUSION PHARMACEUTICALS INC | 0.57% | 3,122,770 | $30,009,820 | | No Change | $9.61 | 13F |
AVBP | ArriVent Biopharma, Inc. | 0.52% | 1,513,664 | $27,245,952 | 1,513,664 | New | | Form 4 |
NMRA | NEUMORA THERAPEUTICS INC. | 0.48% | 1,500,000 | $25,575,000 | | No Change | $17.05 | 13F |
XENE | XENON PHARMACEUTICALS INC | 0.48% | 550,000 | $25,333,000 | -408,793 | -42.64% | $46.06 | 13F |
RYTM | RHYTHM PHARMACEUTICALS INC | 0.47% | 536,642 | $24,669,433 | -47,000 | -8.05% | $45.97 | 13F |
RPTX | REPARE THERAPEUTICS INC | 0.46% | 3,322,488 | $24,254,162 | | No Change | $7.3 | 13F |
ABCL | ABCELLERA BIOLOGICS INC | 0.45% | 4,180,768 | $23,872,185 | | No Change | $5.71 | 13F |
VERA | VERA THERAPEUTICS INC | 0.44% | 1,518,115 | $23,348,609 | | No Change | $15.38 | 13F |
ACET | Adicet Bio, Inc. | 0.39% | 9,772,598 | $19,838,374 | 1,450,458 | 17.43% | | 13D |
KNTE | Kinnate Biopharma Inc. | 0.38% | 7,559,729 | $19,277,309 | -450,000 | -5.62% | | 13D |
PMVP | PMV PHARMACEUTICALS INC | 0.38% | 6,475,291 | $20,073,402 | -87,786 | -1.34% | $3.1 | 13F |
TELA | TELA BIO INC | 0.36% | 2,835,542 | $18,771,288 | | No Change | $6.62 | 13F |
AVTE | AEROVATE THERAPEUTICS INC | 0.32% | 756,930 | $17,129,326 | | No Change | $22.63 | 13F |
IVVD | INVIVYD INC | 0.31% | 4,127,565 | $16,262,606 | -1,142,835 | -21.68% | $3.94 | 13F |
IMTX | IMMATICS N.V | 0.31% | 1,543,407 | $16,252,076 | 493,207 | 46.96% | $10.53 | 13F |
ALNY | ALNYLAM PHARMACEUTICALS INC | 0.29% | 79,400 | $15,197,954 | 79,400 | New | $191.41 | 13F |
PFE | PFIZER INC (Call) | 0.27% | 500,000 | $14,395,000 | 500,000 | New | $28.79 | 13F |
KRYS | KRYSTAL BIOTECH INC | 0.24% | 103,700 | $12,865,022 | 103,700 | New | $124.06 | 13F |
VSTM | VERASTEM INC | 0.24% | 1,529,115 | $12,446,996 | | No Change | $8.14 | 13F |
CRVS | CORVUS PHARMACEUTICALS INC | 0.23% | 6,943,654 | $12,220,831 | | No Change | $1.76 | 13F |
FOLD | AMICUS THERAPEUTICS INC | 0.22% | 806,000 | $11,437,140 | 806,000 | New | $14.19 | 13F |
REGN | REGENERON PHARMACEUTICALS | 0.22% | 13,500 | $11,856,915 | | No Change | $878.29 | 13F |
PASG | Passage BIO, Inc. | 0.21% | 8,034,000 | $10,604,880 | -2,090,576 | -20.65% | | 13D |
ARWR | ARROWHEAD PHARMACEUTICALS IN | 0.19% | 319,651 | $9,781,321 | -114,000 | -26.29% | $30.6 | 13F |
HRTX | HERON THERAPEUTICS INC | 0.19% | 5,928,591 | $10,078,605 | 5,125,891 | 638.58% | $1.7 | 13F |
DXCM | DEXCOM INC | 0.17% | 73,200 | $9,083,388 | 73,200 | New | $124.09 | 13F |
QURE | UNIQURE NV | 0.17% | 1,347,900 | $9,125,283 | -716,555 | -34.71% | $6.77 | 13F |
APLM | APOLLOMICS INC | 0.16% | 8,565,456 | $8,265,665 | -9,428,179 | -52.4% | $0.96 | 13F |
GILD | GILEAD SCIENCES INC | 0.15% | 100,000 | $8,101,000 | | No Change | $81.01 | 13F |
MORF | MORPHIC HLDG INC | 0.15% | 273,400 | $7,895,792 | 64,900 | 31.13% | $28.88 | 13F |
TSBX | TURNSTONE BIOLOGICS CORP | 0.15% | 3,099,265 | $7,887,629 | | No Change | $2.54 | 13F |
IKNA | IKENA ONCOLOGY INC | 0.13% | 3,539,358 | $6,972,535 | 353,192 | 11.09% | $1.97 | 13F |
RAPT | RAPT THERAPEUTICS INC | 0.13% | 281,413 | $6,993,113 | -963,532 | -77.4% | $24.85 | 13F |
CGEM | CULLINAN ONCOLOGY INC | 0.11% | 544,848 | $5,552,001 | | No Change | $10.19 | 13F |
NSPR | INSPIREMD INC | 0.11% | 2,133,405 | $5,994,868 | 273,000 | 14.67% | $2.81 | 13F |
XFOR | X4 PHARMACEUTICALS INC | 0.11% | 7,133,515 | $5,981,452 | | No Change | $0.84 | 13F |
ORIC | ORIC PHARMACEUTICALS INC | 0.09% | 522,968 | $4,811,306 | -370,700 | -41.48% | $9.2 | 13F |
ILMN | ILLUMINA INC | 0.08% | 30,300 | $4,218,972 | 30,300 | New | $139.24 | 13F |
AMAM | AMBRX BIOPHARMA INC | 0.08% | 296,000 | $4,215,040 | 296,000 | New | $14.24 | 13F |
RCUS | ARCUS BIOSCIENCES INC | 0.04% | 117,000 | $2,234,700 | 117,000 | New | $19.1 | 13F |
CLDX | CELLDEX THERAPEUTICS INC NEW | 0.04% | 58,800 | $2,332,008 | 58,800 | New | $39.66 | 13F |
FATE | FATE THERAPEUTICS INC | 0.04% | 528,080 | $1,975,019 | 528,080 | New | $3.74 | 13F |
NXTC | NextCure, Inc. | 0.04% | 1,268,013 | $2,142,942 | -1,443,000 | -53.23% | | 13D |
TXG | 10X GENOMICS INC | 0.04% | 39,800 | $2,227,208 | 39,800 | New | $55.96 | 13F |
BOLT | BOLT BIOTHERAPEUTICS INC | 0.03% | 1,541,000 | $1,725,920 | | No Change | $1.12 | 13F |
CALC | CalciMedica, Inc. | 0.03% | 297,380 | $1,516,638 | | No Change | | 13D |
KZR | KEZAR LIFE SCIENCES INC | 0.03% | 1,927,000 | $1,825,640 | -3,536,000 | -64.73% | $0.95 | 13F |
VIGL | VIGIL NEUROSCIENCE INC | 0.03% | 448,891 | $1,517,252 | | No Change | $3.38 | 13F |
YS | YS BIOPHARMA CO LTD | 0.03% | 3,236,311 | $1,653,755 | -1,305,111 | -28.74% | $0.51 | 13F |
AGIO | AGIOS PHARMACEUTICALS INC | 0.02% | 45,000 | $1,002,150 | 45,000 | New | $22.27 | 13F |
PHGE | BIOMX INC | 0.02% | 4,517,589 | $1,264,925 | -35,900 | -0.79% | $0.28 | 13F |
CMMB | CHEMOMAB THERAPEUTICS LTD | 0.02% | 2,241,274 | $1,143,050 | | No Change | $0.51 | 13F |
ELEV | ELEVATION ONCOLOGY INC | 0.02% | 1,500,000 | $805,500 | | No Change | $0.54 | 13F |
GERN | GERON CORP | 0.02% | 485,000 | $1,023,350 | 485,000 | New | $2.11 | 13F |
VIR | VIR BIOTECHNOLOGY INC | 0.02% | 101,000 | $1,016,060 | 101,000 | New | $10.06 | 13F |
AFIB | ACUTUS MED INC | 0.01% | 2,648,386 | $534,709 | | No Change | $0.2 | 13F |
OMIC | SINGULAR GENOMICS SYSTEMS IN | 0.00472% | 540,697 | $248,775 | | No Change | $0.46 | 13F |
ABBV | ABBVIE INC | | | | -330,000 | Exited | | 13F |
AKRO | AKERO THERAPEUTICS INC | | | | -350,000 | Exited | | 13F |
ALT | ALTIMMUNE INC | | | | -100,000 | Exited | | 13F |
APLS | APELLIS PHARMACEUTICALS INC (Call) | | | | -77,500 | Exited | | 13F |
ARQT | ARCUTIS BIOTHERAPEUTICS INC | | | | -1,914,479 | Exited | | 13F |
AZN | ASTRAZENECA PLC (Call) | | | | -250,000 | Exited | | 13F |
BAX | BAXTER INTL INC | | | | -2,239,900 | Exited | | 13F |
BCAB | BIOATLA INC | | | | -1,009,279 | Exited | | 13F |
CI | THE CIGNA GROUP | | | | -231,500 | Exited | | 13F |
CUTR | CUTERA INC | | | | -603,100 | Exited | | 13F |
DXCM | DEXCOM INC (Call) | | | | -50,000 | Exited | | 13F |
EPIX | ESSA PHARMA INC | | | | -842,366 | Exited | | 13F |
GLTO | GALECTO INC | | | | -924,788 | Exited | | 13F |
GDRX | GOODRX HLDGS INC | | | | -1,595,000 | Exited | | 13F |
HARP | HARPOON THERAPEUTICS INC | | | | -62,121 | Exited | | 13F |
KRTX | KARUNA THERAPEUTICS INC | | | | -14,000 | Exited | | 13F |
KVUE | KENVUE INC | | | | -312,404 | Exited | | 13F |
KVUE | KENVUE INC (Call) | | | | -250,000 | Exited | | 13F |
MDGL | MADRIGAL PHARMACEUTICALS INC | | | | -253,309 | Exited | | 13F |
MRTX | MIRATI THERAPEUTICS INC | | | | -1,959,050 | Exited | | 13F |
MRTX | MIRATI THERAPEUTICS INC (Call) | | | | -100,000 | Exited | | 13F |
MLTX | MOONLAKE IMMUNOTHERAPEUTICS | | | | -117,000 | Exited | | 13F |
TARA | PROTARA THERAPEUTICS INC | | | | -772,584 | Exited | | 13F |
RLAY | RELAY THERAPEUTICS INC | | | | -501,966 | Exited | | 13F |
SGEN | SEAGEN INC | | | | -42,600 | Exited | | 13F |
SGEN | SEAGEN INC (Call) | | | | -50,000 | Exited | | 13F |
SYBX | SYNLOGIC INC | | | | -401,998 | Exited | | 13F |
TDOC | TELADOC HEALTH INC | | | | -110,000 | Exited | | 13F |
VTYX | VENTYX BIOSCIENCES INC | | | | -340,384 | Exited | | 13F |
XNCR | XENCOR INC | | | | -19,142 | Exited | | 13F |
HZNP | HORIZON THERAPEUTICS PUB L | | | | -266,400 | Exited | | 13F |
IMTX | IMMATICS N.V (Call) | | | | -125,000 | Exited | | 13F |