| HZNP | HORIZON PHARMA PLC | 9.69% | 13,740,261 | $227,676,000 | 2,055,460 | 17.59% | $16.57 | 13F |
| MYL | MYLAN N V | 3.62% | 1,832,535 | $84,938,000 | 776,535 | 73.54% | $46.35 | 13F |
| NXTM | NXSTAGE MEDICAL INC | 3.51% | 5,506,028 | $82,535,000 | 917,028 | 19.98% | $14.99 | 13F |
| HEALTHWAYS INC (PRN) | 3.01% | 76,925,000 | $70,595,000 | 25,000,000 | 48.15% | $0.92 | 13F |
| HZNP | HORIZON PHARMA INVT LTD (PRN) | 3% | 82,600,000 | $70,475,000 | 82,600,000 | New | $0.85 | 13F |
| GSK | GLAXOSMITHKLINE PLC | 2.89% | 1,675,385 | $67,937,000 | | No Change | $40.55 | 13F |
| AET | AETNA INC NEW | 2.83% | 591,465 | $66,451,000 | | No Change | $112.35 | 13F |
| PTLA | PORTOLA PHARMACEUTICALS INC | 2.68% | 3,089,785 | $63,032,000 | 2,406,036 | 351.89% | $20.4 | 13F |
| AVXS | AVEXIS INC | 2.59% | 2,236,701 | $60,928,000 | 2,236,701 | New | $27.24 | 13F |
| DVA | DAVITA HEALTHCARE PARTNERS I | 2.57% | 822,000 | $60,318,000 | | No Change | $73.38 | 13F |
| EDIT | EDITAS MEDICINE INC | 2.51% | 1,709,400 | $59,043,000 | 1,709,400 | New | $34.54 | 13F |
| ADPTQ | ADEPTUS HEALTH INC | 2.26% | 956,533 | $53,126,000 | -351,375 | -26.87% | $55.54 | 13F |
| XNPT | XENOPORT INC | 2.22% | 11,572,125 | $52,190,000 | 5,284,751 | 84.05% | $4.51 | 13F |
| VNDA | VANDA PHARMACEUTICALS INC | 2.13% | 5,996,691 | $50,132,000 | | No Change | $8.36 | 13F |
| GWPH | GW PHARMACEUTICALS PLC | 2.07% | 674,373 | $48,656,000 | 364,251 | 117.45% | $72.15 | 13F |
| XNCR | XENCOR INC | 1.98% | 3,467,512 | $46,534,000 | 2,210,900 | 175.94% | $13.42 | 13F |
| AACH | AAC HLDGS INC | 1.93% | 2,294,936 | $45,417,000 | 512,842 | 28.78% | $19.79 | 13F |
| FLML | FLAMEL TECHNOLOGIES SA | 1.91% | 4,072,809 | $44,964,000 | | No Change | $11.04 | 13F |
| WBA | WALGREENS BOOTS ALLIANCE INC | 1.83% | 511,457 | $43,085,000 | 125,000 | 32.35% | $84.24 | 13F |
| ELGX | ENDOLOGIX INC (PRN) | 1.64% | 40,000,000 | $38,632,000 | 10,000,000 | 33.33% | $0.97 | 13F |
| UAM | UNIVERSAL AMERN CORP NEW | 1.61% | 5,285,500 | $37,738,000 | 496,473 | 10.37% | $7.14 | 13F |
| HTWR | HEARTWARE INTL INC (PRN) | 1.55% | 39,226,000 | $36,498,000 | | No Change | $0.93 | 13F |
| ARRY | ARRAY BIOPHARMA INC (PRN) | 1.53% | 45,000,000 | $35,876,000 | | No Change | $0.8 | 13F |
| T107PS | WRIGHT MED GROUP INC (PRN) | 1.53% | 40,050,000 | $35,961,000 | 40,050,000 | New | $0.9 | 13F |
| SAGE | SAGE THERAPEUTICS INC | 1.52% | 1,113,654 | $35,704,000 | 514,800 | 85.96% | $32.06 | 13F |
| AERI | AERIE PHARMACEUTICALS INC | 1.36% | 2,632,482 | $32,011,000 | 1,824,607 | 225.85% | $12.16 | 13F |
| EHTH | EHEALTH INC | 1.31% | 3,264,588 | $30,654,000 | | No Change | $9.39 | 13F |
| ZLTQ | ZELTIQ AESTHETICS INC | 1.28% | 1,104,417 | $29,996,000 | 1,104,417 | New | $27.16 | 13F |
| ENDOLOGIX INC (PRN) | 1.27% | 40,941,000 | $29,871,000 | | No Change | $0.73 | 13F |
| ARRY | ARRAY BIOPHARMA INC | 1.2% | 9,529,361 | $28,112,000 | 800,000 | 9.16% | $2.95 | 13F |
| FPRX | FIVE PRIME THERAPEUTICS INC | 1.18% | 680,000 | $27,628,000 | | No Change | $40.63 | 13F |
| MCK | MCKESSON CORP | 1.17% | 175,000 | $27,519,000 | 30,354 | 20.99% | $157.25 | 13F |
| ACOR | ACORDA THERAPEUTICS INC | 1.16% | 1,029,410 | $27,228,000 | 1,029,410 | New | $26.45 | 13F |
| HTWR | HEARTWARE INTL INC | 1.16% | 870,634 | $27,355,000 | 710,673 | 444.28% | $31.42 | 13F |
| DBVT | DBV TECHNOLOGIES S A | 1.13% | 817,806 | $26,620,000 | 355,937 | 77.06% | $32.55 | 13F |
| RLYP | RELYPSA INC | 1.08% | 1,873,471 | $25,386,000 | 973,190 | 108.1% | $13.55 | 13F |
| HWAY | HEALTHWAYS INC | 1.06% | 2,475,387 | $24,977,000 | 10,345 | 0.42% | $10.09 | 13F |
| SPNC | SPECTRANETICS CORP (PRN) | 1.01% | 29,831,000 | $23,643,000 | | No Change | $0.79 | 13F |
| INFI | INFINITY PHARMACEUTICALS INC | 0.99% | 4,398,862 | $23,182,000 | 93,574 | 2.17% | $5.27 | 13F |
| KMPH | KEMPHARM INC | 0.88% | 1,420,497 | $20,597,000 | | No Change | $14.5 | 13F |
| ZFGN | ZAFGEN INC | 0.87% | 3,055,603 | $20,411,000 | 2,211,938 | 262.18% | $6.68 | 13F |
| DNAI | PRONAI THERAPEUTICS INC | 0.86% | 3,001,302 | $20,229,000 | 1,210,047 | 67.55% | $6.74 | 13F |
| RAD | RITE AID CORP | 0.83% | 2,393,072 | $19,504,000 | -99,700 | -4% | $8.15 | 13F |
| GBT | GLOBAL BLOOD THERAPEUTICS IN | 0.81% | 1,193,811 | $18,934,000 | 30,000 | 2.58% | $15.86 | 13F |
| AXGN | AXOGEN INC | 0.77% | 3,381,439 | $18,125,000 | | No Change | $5.36 | 13F |
| AKTX | AKARI THERAPEUTICS PLC | 0.69% | 1,150,700 | $16,110,000 | | No Change | $14 | 13F |
| NVLS | NIVALIS THERAPEUTICS INC | 0.66% | 3,732,412 | $15,564,000 | | No Change | $4.17 | 13F |
| LAB | FLUIDIGM CORP DEL (PRN) | 0.65% | 27,715,000 | $15,353,000 | | No Change | $0.55 | 13F |
| ELV | ANTHEM INC | 0.6% | 102,000 | $14,177,000 | 87,351 | 596.29% | $138.99 | 13F |
| GLPG | GALAPAGOS NV | 0.58% | 327,626 | $13,701,000 | 144,626 | 79.03% | $41.82 | 13F |
| NVAX | NOVAVAX INC | 0.54% | 2,456,261 | $12,674,000 | 2,456,261 | New | $5.16 | 13F |
| RGNX | REGENXBIO INC | 0.54% | 1,169,042 | $12,626,000 | | No Change | $10.8 | 13F |
| IMPR | IMPRIVATA INC | 0.53% | 983,366 | $12,420,000 | -223,052 | -18.49% | $12.63 | 13F |
| CTMX | CYTOMX THERAPEUTICS INC | 0.52% | 943,433 | $12,170,000 | -2,589 | -0.27% | $12.9 | 13F |
| ALIM | ALIMERA SCIENCES INC | 0.44% | 5,878,015 | $10,287,000 | | No Change | $1.75 | 13F |
| PRTO | PROTEON THERAPEUTICS INC | 0.42% | 1,265,343 | $9,794,000 | | No Change | $7.74 | 13F |
| IVTY | INVUITY INC | 0.41% | 1,327,009 | $9,581,000 | 248,791 | 23.07% | $7.22 | 13F |
| MGNX | MACROGENICS INC | 0.41% | 517,920 | $9,711,000 | | No Change | $18.75 | 13F |
| XLRN | ACCELERON PHARMA INC | 0.4% | 353,491 | $9,329,000 | 140,000 | 65.58% | $26.39 | 13F |
| GI | ENDOCHOICE HLDGS INC | 0.4% | 1,823,309 | $9,499,000 | | No Change | $5.21 | 13F |
| NSTG | NANOSTRING TECHNOLOGIES INC | 0.39% | 606,222 | $9,227,000 | -274,400 | -31.16% | $15.22 | 13F |
| EPIX | ESSA PHARMA INC | 0.36% | 2,587,215 | $8,408,000 | 727,933 | 39.15% | $3.25 | 13F |
| CPHD | CEPHEID (PRN) | 0.29% | 7,750,000 | $6,917,000 | 7,750,000 | New | $0.89 | 13F |
| LOXO | LOXO ONCOLOGY INC | 0.29% | 251,000 | $6,862,000 | | No Change | $27.34 | 13F |
| SEM | SELECT MED HLDGS CORP | 0.28% | 559,097 | $6,603,000 | 559,097 | New | $11.81 | 13F |
| GNCA | GENOCEA BIOSCIENCES INC | 0.26% | 787,257 | $6,093,000 | -50,000 | -5.97% | $7.74 | 13F |
| FOMX | FOAMIX PHARMACEUTICALS LTD | 0.26% | 948,934 | $6,187,000 | | No Change | $6.52 | 13F |
| ARLZ | ARALEZ PHARMACEUTICALS INC | 0.25% | 1,644,583 | $5,838,000 | 1,644,583 | New | $3.55 | 13F |
| JAZZ INVESTMENTS I LTD (PRN) | 0.22% | 5,000,000 | $5,111,000 | | No Change | $1.02 | 13F |
| NEOS | NEOS THERAPEUTICS INC | 0.21% | 458,332 | $4,945,000 | | No Change | $10.79 | 13F |
| RIGL | RIGEL PHARMACEUTICALS INC | 0.21% | 2,397,855 | $4,988,000 | | No Change | $2.08 | 13F |
| ABMD | ABIOMED INC | 0.2% | 49,797 | $4,721,000 | 49,797 | New | $94.8 | 13F |
| ELGX | ENDOLOGIX INC | 0.2% | 569,895 | $4,764,000 | 569,895 | New | $8.36 | 13F |
| OXFD | OXFORD IMMUNOTEC GLOBAL PLC | 0.2% | 464,541 | $4,604,000 | -55,129 | -10.61% | $9.91 | 13F |
| CASM | CAS MED SYS INC | 0.19% | 3,200,000 | $4,544,000 | | No Change | $1.42 | 13F |
| EGLTQ | EGALET CORP | 0.17% | 597,123 | $4,096,000 | 120,000 | 25.15% | $6.86 | 13F |
| MYOK | MYOKARDIA INC | 0.17% | 374,800 | $4,014,000 | -200 | -0.05% | $10.71 | 13F |
| PSDV | PSIVIDA CORP | 0.17% | 1,492,824 | $4,001,000 | 270,714 | 22.15% | $2.68 | 13F |
| ADHD | ALCOBRA LTD | 0.17% | 1,069,914 | $4,055,000 | | No Change | $3.79 | 13F |
| SCYX | SCYNEXIS INC | 0.15% | 848,000 | $3,417,000 | 151,719 | 21.79% | $4.03 | 13F |
| CATB | CATABASIS PHARMACEUTICALS IN | 0.14% | 643,580 | $3,244,000 | | No Change | $5.04 | 13F |
| STDY | STEADYMED LTD | 0.14% | 1,346,744 | $3,313,000 | | No Change | $2.46 | 13F |
| TNXP | TONIX PHARMACEUTICALS HLDG C | 0.13% | 1,315,551 | $3,170,000 | | No Change | $2.41 | 13F |
| ACUR | ACURA PHARMACEUTICALS INC | 0.12% | 1,025,641 | $2,903,000 | | No Change | $2.83 | 13F |
| TCON | TRACON PHARMACEUTICALS INC | 0.12% | 397,085 | $2,776,000 | -87,915 | -18.13% | $6.99 | 13F |
| ARDX | ARDELYX INC | 0.09% | 275,000 | $2,137,000 | 275,000 | New | $7.77 | 13F |
| VYGR | VOYAGER THERAPEUTICS INC | 0.09% | 235,294 | $2,054,000 | | No Change | $8.73 | 13F |
| ALDX | ALDEYRA THERAPEUTICS INC | 0.08% | 471,259 | $1,975,000 | -219,279 | -31.75% | $4.19 | 13F |
| AGRX | AGILE THERAPEUTICS INC | 0.07% | 250,000 | $1,553,000 | 250,000 | New | $6.21 | 13F |
| TRMB | TRILLIUM THERAPEUTICS INC | 0.07% | 172,307 | $1,594,000 | | No Change | $9.25 | 13F |
| TRUP | TRUPANION INC | 0.07% | 155,236 | $1,529,000 | -906,978 | -85.39% | $9.85 | 13F |
| ATEC | ALPHATEC HOLDINGS INC | 0.05% | 4,982,738 | $1,196,000 | | No Change | $0.24 | 13F |
| CDNA | CAREDX INC | 0.05% | 229,000 | $1,136,000 | | No Change | $4.96 | 13F |
| CDTX | CIDARA THERAPEUTICS INC | 0.04% | 68,779 | $873,000 | -50,677 | -42.42% | $12.69 | 13F |
| STRM | STREAMLINE HEALTH SOLUTIONS | 0.04% | 662,971 | $935,000 | | No Change | $1.41 | 13F |
| VCYT | VERACYTE INC | 0.04% | 165,097 | $892,000 | -227,050 | -57.9% | $5.4 | 13F |
| AGN | ALLERGAN PLC | 0.04% | 3,500 | $938,000 | 3,500 | New | $268 | 13F |
| CORSICANTO LTD (PRN) | 0.03% | 1,000,000 | $821,000 | | No Change | $0.82 | 13F |
| PFE | PFIZER INC | 0.03% | 25,000 | $741,000 | 25,000 | New | $29.64 | 13F |
| ALQA | ALLIQUA BIOMEDICAL INC | 0.02% | 667,246 | $547,000 | -1,212,888 | -64.51% | $0.82 | 13F |
| PTN | PALATIN TECHNOLOGIES INC | 0.02% | 985,693 | $532,000 | -1,014,307 | -50.72% | $0.54 | 13F |
| WMGI | WRIGHT MED GROUP N V | 0.02% | 30,000 | $498,000 | 30,000 | New | $16.6 | 13F |
| RNVA | RENNOVA HEALTH INC | 0.01% | 353,933 | $265,000 | -205,498 | -36.73% | $0.75 | 13F |
| OCRX | OCERA THERAPEUTICS INC | 0.00941% | 75,293 | $221,000 | 75,293 | New | $2.94 | 13F |
| RNVAW | RENNOVA HEALTH INC | 0.00217% | 645,161 | $51,000 | | No Change | $0.08 | 13F |
| ARAY | ACCURAY INC (PRN) | | | | -30,511,000 | Exited | | 13F |
| ACHN | ACHILLION PHARMACEUTICALS IN | | | | -1,667,000 | Exited | | 13F |
| MDRXD | ALLSCRIPTS HEALTHCARE SOLUTN (PRN) | | | | -12,400,000 | Exited | | 13F |
| ATRS | ANTARES PHARMA INC | | | | -3,983,440 | Exited | | 13F |
| ABC | AMERISOURCEBERGEN CORP | | | | -3,000 | Exited | | 13F |
| BVX | BOVIE MEDICAL CORP | | | | -688,229 | Exited | | 13F |
| CTIC | CTI BIOPHARMA CORP | | | | -2,236,832 | Exited | | 13F |
| CSII | CARDIOVASCULAR SYS INC DEL | | | | -1,035,000 | Exited | | 13F |
| CNC | CENTENE CORP DEL | | | | -244,000 | Exited | | 13F |
| CRL | CHARLES RIV LABS INTL INC | | | | -377,188 | Exited | | 13F |
| DYAX | DYAX CORP | | | | -2,242,073 | Exited | | 13F |
| GENN | GENESIS HEALTHCARE INC | | | | -963,564 | Exited | | 13F |
| GHDX | GENOMIC HEALTH INC | | | | -809,432 | Exited | | 13F |
| GILD | GILEAD SCIENCES INC (Call) | | | | -532,000 | Exited | | 13F |
| IMMU | IMMUNOMEDICS INC | | | | -1,073,640 | Exited | | 13F |
| PACB | PACIFIC BIOSCIENCES CALIF IN | | | | -1,388,000 | Exited | | 13F |
| PCRX | PACIRA PHARMACEUTICALS INC | | | | -371,000 | Exited | | 13F |
| POZN | POZEN INC | | | | -44,583 | Exited | | 13F |
| TEVA | TEVA PHARMACEUTICAL INDS LTD | | | | -815,000 | Exited | | 13F |
| TEVA | TEVA PHARMACEUTICAL INDS LTD (Call) | | | | -550,000 | Exited | | 13F |
| TRIB | TRINITY BIOTECH PLC | | | | -246,000 | Exited | | 13F |
| VSAR | VERSARTIS INC | | | | -490,503 | Exited | | 13F |
