| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Reshma Kewalramani | CEO & President | Aug 06, 2025 | Buy | $389.58 | 10,000 | 3,895,768 | 115,968 | Aug 07, 2025, 04:23 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Reshma Kewalramani | CEO & President | Feb 26, 2025 | Tax Payment (Shares) | $479.61 | 14,079 | 6,752,429 | 105,915 | Feb 28, 2025, 04:43 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Reshma Kewalramani | CEO & President | Feb 24, 2025 | Tax Payment (Shares) | $483.28 | 9,386 | 4,536,066 | 119,994 | Feb 26, 2025, 04:12 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Reshma Kewalramani | CEO & President | Feb 14, 2025 | Tax Payment (Shares) | $463.46 | 6,553 | 3,037,053 | 129,380 | Feb 19, 2025, 04:31 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Reshma Kewalramani | CEO & President | Feb 10, 2025 | Tax Payment (Shares) | $467.98 | 8,300 | 3,884,234 | 116,918 | Feb 12, 2025, 04:46 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Reshma Kewalramani | CEO & President | Nov 08, 2024 | Sale | $515.00 | 15,198 | 7,826,970 | 75,772 | Nov 12, 2024, 04:08 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Reshma Kewalramani | CEO & President | Jul 30, 2024 | Sale | $505.00 | 15,202 | 7,677,010 | 90,970 | Aug 01, 2024, 04:17 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Reshma Kewalramani | CEO & President | Jul 22, 2024 | Sale | $497.00 | 15,202 | 7,555,394 | 106,172 | Jul 24, 2024, 04:05 PM |
| DNA | | Ginkgo Bioworks Holdings, Inc. | Reshma Kewalramani | Director | Jun 12, 2024 | Option/RSU Exercise | - | 105,263 | - | 186,002 | Jun 14, 2024, 04:24 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Reshma Kewalramani | CEO & President | May 24, 2024 | Option/RSU Exercise | $187.53 | 1,565 | 293,484 | 122,939 | May 29, 2024, 04:08 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Reshma Kewalramani | CEO & President | May 24, 2024 | Sale | $457.00 | 1,565 | 715,205 | 121,374 | May 29, 2024, 04:08 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Reshma Kewalramani | CEO & President | May 20, 2024 | Sale | $447.00 | 15,202 | 6,795,294 | 121,374 | May 22, 2024, 04:21 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Reshma Kewalramani | CEO & President | Feb 23, 2024 | Tax Payment (Shares) | $431.79 | 9,386 | 4,052,781 | 136,507 | Feb 27, 2024, 04:55 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Reshma Kewalramani | CEO & President | Feb 09, 2024 | Tax Payment (Shares) | $422.74 | 8,255 | 3,489,719 | 162,271 | Feb 13, 2024, 05:07 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Reshma Kewalramani | CEO & President | Dec 15, 2023 | Option/RSU Exercise | $181.83 | 17,135 | 3,115,593 | 125,846 | Dec 19, 2023, 04:15 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Reshma Kewalramani | CEO & President | Dec 15, 2023 | Sale | $407.00 | 17,135 | 6,973,945 | 108,711 | Dec 19, 2023, 04:15 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Reshma Kewalramani | CEO & President | Dec 13, 2023 | Sale | $397.00 | 5,098 | 2,023,906 | 108,711 | Dec 15, 2023, 04:23 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Reshma Kewalramani | CEO & President | Nov 13, 2023 | Sale | $377.00 | 5,097 | 1,921,569 | 113,809 | Nov 15, 2023, 04:16 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Reshma Kewalramani | CEO & President | Jul 17, 2023 | Sale | $355.00 | 7,828 | 2,778,940 | 118,906 | Jul 18, 2023, 04:13 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Reshma Kewalramani | CEO & President | Apr 27, 2023 | Sale | $339.08 | 3,317 | 1,124,726 | 128,358 | May 01, 2023, 04:26 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Reshma Kewalramani | CEO & President | Feb 24, 2023 | Tax Payment (Shares) | $289.12 | 9,386 | 2,713,680 | 129,969 | Feb 28, 2023, 04:53 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Reshma Kewalramani | CEO & President | Feb 17, 2023 | Tax Payment (Shares) | $292.85 | 9,359 | 2,740,783 | 139,355 | Feb 22, 2023, 04:35 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Reshma Kewalramani | CEO & President | Feb 10, 2023 | Tax Payment (Shares) | $294.33 | 3,372 | 992,481 | 154,704 | Feb 14, 2023, 04:58 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Reshma Kewalramani | CEO & President | Feb 13, 2023 | Tax Payment (Shares) | $298.26 | 5,990 | 1,786,577 | 148,714 | Feb 14, 2023, 04:58 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Reshma Kewalramani | CEO & President | Jan 25, 2023 | Sale | $315.05 | 10,000 | 3,150,500 | 89,598 | Jan 27, 2023, 04:13 PM |
| DNA | | Ginkgo Bioworks Holdings, Inc. | Reshma Kewalramani | Director | Sep 30, 2022 | Option/RSU Exercise | - | 9,818 | - | 80,739 | Nov 10, 2022, 05:30 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Reshma Kewalramani | CEO & President | Aug 15, 2022 | Sale | $305.06 | 11,689 | 3,565,846 | 99,598 | Aug 17, 2022, 05:40 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Reshma Kewalramani | CEO & President | Jun 24, 2022 | Sale | $291.30 | 11,689 | 3,405,006 | 111,153 | Jun 28, 2022, 04:05 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Reshma Kewalramani | CEO & President | Feb 24, 2022 | Tax Payment (Shares) | $227.86 | 7,246 | 1,651,074 | 122,842 | Feb 28, 2022, 05:21 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Reshma Kewalramani | CEO & President | Feb 17, 2022 | Tax Payment (Shares) | $232.51 | 8,584 | 1,995,866 | 130,088 | Feb 22, 2022, 04:56 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Reshma Kewalramani | CEO & President | Feb 10, 2022 | Tax Payment (Shares) | $237.74 | 3,031 | 720,590 | 138,672 | Feb 14, 2022, 04:16 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Reshma Kewalramani | CEO & President | Aug 19, 2021 | Buy | $195.65 | 10,000 | 1,956,492 | 73,754 | Aug 23, 2021, 08:30 AM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Reshma Kewalramani | CEO & President | Feb 24, 2021 | Tax Payment (Shares) | $217.57 | 2,898 | 630,518 | 63,643 | Feb 26, 2021, 04:15 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Reshma Kewalramani | CEO & President | Feb 17, 2021 | Tax Payment (Shares) | $211.75 | 2,080 | 440,440 | 66,541 | Feb 19, 2021, 04:12 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Reshma Kewalramani | CEO & President | Feb 10, 2021 | Tax Payment (Shares) | $214.16 | 2,962 | 634,342 | 68,621 | Feb 12, 2021, 04:07 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Reshma Kewalramani | CEO & President | Aug 06, 2020 | Option/RSU Exercise | $179.68 | 2,073 | 372,482 | 28,699 | Aug 10, 2020, 04:19 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Reshma Kewalramani | CEO & President | Aug 06, 2020 | Sale | $271.20 | 2,073 | 562,205 | 28,547 | Aug 10, 2020, 04:19 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Reshma Kewalramani | CEO & President | May 15, 2020 | Sale | $284.17 | 99 | 28,132 | 26,723 | May 19, 2020, 04:35 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Reshma Kewalramani | CEO & President | May 06, 2020 | Option/RSU Exercise | $179.67 | 2,074 | 372,638 | 28,700 | May 08, 2020, 04:19 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Reshma Kewalramani | CEO & President | May 06, 2020 | Sale | $272.85 | 2,074 | 565,882 | 28,284 | May 08, 2020, 04:19 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Reshma Kewalramani | EVP and CMO | Feb 24, 2020 | Tax Payment (Shares) | $239.23 | 2,898 | 693,289 | 30,260 | Feb 26, 2020, 04:32 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Reshma Kewalramani | EVP and CMO | Feb 25, 2020 | Sale | $233.45 | 3,634 | 848,371 | 29,367 | Feb 26, 2020, 04:32 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Reshma Kewalramani | EVP and CMO | Feb 17, 2020 | Tax Payment (Shares) | $241.50 | 944 | 227,976 | 34,341 | Feb 19, 2020, 04:33 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Reshma Kewalramani | EVP and CMO | Feb 18, 2020 | Sale | $243.51 | 1,183 | 288,070 | 34,221 | Feb 19, 2020, 04:33 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Reshma Kewalramani | EVP and CMO | Feb 06, 2020 | Sale | $239.44 | 2,074 | 496,600 | 36,108 | Feb 07, 2020, 04:14 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Reshma Kewalramani | EVP and CMO | Feb 06, 2020 | Option/RSU Exercise | $179.67 | 2,074 | 372,638 | 37,359 | Feb 07, 2020, 04:14 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Reshma Kewalramani | EVP and CMO | Nov 25, 2019 | Option/RSU Exercise | $187.53 | 4,692 | 879,891 | 17,790 | Nov 26, 2019, 04:12 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Reshma Kewalramani | EVP and CMO | Nov 25, 2019 | Sale | $219.37 | 4,692 | 1,029,284 | 13,098 | Nov 26, 2019, 04:12 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Reshma Kewalramani | EVP and CMO | Nov 15, 2019 | Sale | $205.95 | 61 | 12,563 | 13,098 | Nov 19, 2019, 04:11 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Reshma Kewalramani | EVP and CMO | Nov 08, 2019 | Option/RSU Exercise | $155.57 | 509 | 79,185 | 13,607 | Nov 13, 2019, 04:08 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Reshma Kewalramani | EVP and CMO | Nov 08, 2019 | Sale | $199.00 | 509 | 101,291 | 13,098 | Nov 13, 2019, 04:08 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Reshma Kewalramani | EVP and CMO | Oct 30, 2019 | Option/RSU Exercise | $155.57 | 3,057 | 475,578 | 16,155 | Oct 31, 2019, 04:36 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Reshma Kewalramani | EVP and CMO | Oct 30, 2019 | Sale | $199.00 | 3,057 | 608,343 | 13,098 | Oct 31, 2019, 04:36 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Reshma Kewalramani | EVP and CMO | Oct 22, 2019 | Sale | $189.00 | 638 | 120,582 | 13,098 | Oct 24, 2019, 07:18 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Reshma Kewalramani | EVP and CMO | May 15, 2019 | Sale | $165.41 | 241 | 39,864 | 13,736 | May 17, 2019, 04:21 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Reshma Kewalramani | EVP and CMO | Feb 19, 2019 | Sale | $186.94 | 1,488 | 278,163 | 14,038 | Feb 21, 2019, 04:22 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Reshma Kewalramani | EVP and CMO | Oct 08, 2018 | Sale | $186.95 | 2,305 | 430,920 | 1,909 | Oct 09, 2018, 04:50 PM |
