| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Hunter C. Smith | Chief Financial Officer | May 18, 2026 | Option/RSU Exercise | $17.87 | 3,000 | 53,610 | 119,611 | May 20, 2026, 04:15 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Hunter C. Smith | Chief Financial Officer | Mar 02, 2026 | Option/RSU Exercise | $6.80 | 6,099 | 41,473 | 116,611 | Mar 02, 2026, 08:56 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Hunter C. Smith | Chief Financial Officer | Feb 17, 2026 | Sale | $101.38 | 3,569 | 361,810 | 117,266 | Feb 19, 2026, 09:02 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Hunter C. Smith | Chief Financial Officer | Feb 19, 2026 | Sale | $101.26 | 4,385 | 444,004 | 113,589 | Feb 19, 2026, 09:02 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Hunter C. Smith | Chief Financial Officer | Feb 12, 2026 | Sale | $98.23 | 1,592 | 156,380 | 119,766 | Feb 12, 2026, 08:56 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Hunter C. Smith | Chief Financial Officer | Feb 10, 2026 | Sale | $103.00 | 2,713 | 279,429 | 123,624 | Feb 12, 2026, 08:56 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Hunter C. Smith | Chief Financial Officer | Feb 11, 2026 | Sale | $98.61 | 2,766 | 272,766 | 120,558 | Feb 12, 2026, 08:56 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Hunter C. Smith | Chief Financial Officer | Feb 04, 2026 | Sale | $105.99 | 3,247 | 344,145 | 130,665 | Feb 06, 2026, 06:38 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Hunter C. Smith | Chief Financial Officer | Feb 05, 2026 | Sale | $106.06 | 3,381 | 358,599 | 125,537 | Feb 06, 2026, 06:38 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Hunter C. Smith | Chief Financial Officer | Feb 01, 2026 | Tax Payment (Shares) | $108.99 | 10,750 | 1,171,642 | 132,165 | Feb 03, 2026, 04:36 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Hunter C. Smith | Chief Financial Officer | Feb 01, 2026 | Option/RSU Exercise | - | 26,000 | - | 142,915 | Feb 03, 2026, 04:36 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Hunter C. Smith | Chief Financial Officer | Aug 12, 2025 | Option/RSU Exercise | $6.88 | 24,611 | 169,324 | 141,526 | Aug 14, 2025, 06:48 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Hunter C. Smith | Chief Financial Officer | Aug 12, 2025 | Sale | $96.33 | 24,611 | 2,370,832 | 116,915 | Aug 14, 2025, 06:48 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Hunter C. Smith | Chief Financial Officer | Aug 13, 2025 | Option/RSU Exercise | $6.88 | 3,477 | 23,922 | 120,392 | Aug 14, 2025, 06:48 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Hunter C. Smith | Chief Financial Officer | Aug 13, 2025 | Sale | $96.00 | 3,477 | 333,792 | 116,915 | Aug 14, 2025, 06:48 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Hunter C. Smith | Chief Financial Officer | Jul 09, 2025 | Option/RSU Exercise | $6.88 | 42,120 | 289,786 | 159,035 | Jul 11, 2025, 04:31 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Hunter C. Smith | Chief Financial Officer | Jul 09, 2025 | Sale | $80.48 | 42,120 | 3,389,756 | 141,922 | Jul 11, 2025, 04:31 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Hunter C. Smith | Chief Financial Officer | Jul 07, 2025 | Option/RSU Exercise | $6.88 | 6,986 | 48,064 | 116,915 | Jul 08, 2025, 04:30 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Hunter C. Smith | Chief Financial Officer | May 30, 2025 | Option/RSU Exercise | $6.88 | 23,400 | 160,992 | 133,329 | Jun 03, 2025, 04:15 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Hunter C. Smith | Chief Financial Officer | May 30, 2025 | Sale | $61.41 | 23,400 | 1,437,010 | 128,922 | Jun 03, 2025, 04:15 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Hunter C. Smith | Chief Financial Officer | Feb 19, 2025 | Sale | $57.22 | 2,215 | 126,742 | 109,929 | Feb 19, 2025, 09:50 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Hunter C. Smith | Chief Financial Officer | Feb 16, 2025 | Option/RSU Exercise | - | 6,600 | - | 112,144 | Feb 19, 2025, 09:50 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Hunter C. Smith | Chief Financial Officer | Feb 12, 2025 | Sale | $56.39 | 751 | 42,347 | 105,556 | Feb 14, 2025, 04:59 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Hunter C. Smith | Chief Financial Officer | Feb 09, 2025 | Option/RSU Exercise | - | 4,062 | - | 105,248 | Feb 11, 2025, 09:44 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Hunter C. Smith | Chief Financial Officer | Feb 11, 2025 | Option/RSU Exercise | - | 2,343 | - | 107,591 | Feb 11, 2025, 09:44 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Hunter C. Smith | Chief Financial Officer | Feb 11, 2025 | Sale | $57.51 | 1,296 | 74,533 | 106,300 | Feb 11, 2025, 09:44 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Hunter C. Smith | Chief Financial Officer | Feb 01, 2025 | Option/RSU Exercise | - | 4,925 | - | 102,864 | Feb 04, 2025, 09:27 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Hunter C. Smith | Chief Financial Officer | Feb 04, 2025 | Sale | $59.43 | 1,678 | 99,724 | 101,186 | Feb 04, 2025, 09:27 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Hunter C. Smith | Chief Financial Officer | Mar 19, 2024 | Sale | $39.22 | 15,515 | 608,498 | 97,939 | Mar 19, 2024, 08:57 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Hunter C. Smith | Chief Financial Officer | Feb 12, 2024 | Sale | $51.38 | 1,209 | 62,118 | 80,413 | Feb 13, 2024, 08:50 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Hunter C. Smith | Chief Financial Officer | Feb 13, 2024 | Sale | $49.82 | 709 | 35,322 | 79,704 | Feb 13, 2024, 08:50 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Hunter C. Smith | Chief Financial Officer | Feb 09, 2024 | Option/RSU Exercise | - | 4,063 | - | 79,278 | Feb 13, 2024, 08:50 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Hunter C. Smith | Chief Financial Officer | Feb 11, 2024 | Option/RSU Exercise | - | 2,344 | - | 81,622 | Feb 13, 2024, 08:50 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Hunter C. Smith | Chief Financial Officer | Feb 01, 2024 | Option/RSU Exercise | - | 4,925 | - | 76,831 | Feb 05, 2024, 06:54 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Hunter C. Smith | Chief Financial Officer | Feb 01, 2024 | Sale | $45.06 | 1,616 | 72,817 | 75,215 | Feb 05, 2024, 06:54 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Hunter C. Smith | Chief Financial Officer | Dec 29, 2023 | Option/RSU Exercise | $6.88 | 10,500 | 72,240 | 71,906 | Jan 03, 2024, 04:15 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Hunter C. Smith | Chief Financial Officer | Dec 06, 2023 | Sale | $40.00 | 20,000 | 800,000 | 61,406 | Dec 07, 2023, 04:16 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Hunter C. Smith | Chief Financial Officer | Dec 05, 2023 | Option/RSU Exercise | $6.88 | 7,026 | 48,339 | 68,432 | Dec 07, 2023, 04:16 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Hunter C. Smith | Chief Financial Officer | Dec 05, 2023 | Sale | $35.06 | 7,026 | 246,360 | 61,406 | Dec 07, 2023, 04:16 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Hunter C. Smith | Chief Financial Officer | Dec 06, 2023 | Option/RSU Exercise | $6.88 | 20,000 | 137,600 | 81,406 | Dec 07, 2023, 04:16 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Hunter C. Smith | Chief Financial Officer | Nov 24, 2023 | Option/RSU Exercise | $6.88 | 10,974 | 75,501 | 72,380 | Nov 28, 2023, 04:05 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Hunter C. Smith | Chief Financial Officer | Nov 24, 2023 | Sale | $35.02 | 10,974 | 384,336 | 61,406 | Nov 28, 2023, 04:05 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Hunter C. Smith | Chief Financial Officer | Nov 14, 2023 | Option/RSU Exercise | $6.88 | 12,000 | 82,560 | 73,406 | Nov 16, 2023, 04:05 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Hunter C. Smith | Chief Financial Officer | Nov 14, 2023 | Sale | $30.38 | 12,000 | 364,573 | 61,406 | Nov 16, 2023, 04:05 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Hunter C. Smith | Chief Financial Officer | Jun 16, 2023 | Option/RSU Exercise | $6.88 | 2,000 | 13,760 | 61,406 | Jun 21, 2023, 04:05 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Hunter C. Smith | Chief Financial Officer | Feb 11, 2023 | Option/RSU Exercise | - | 2,344 | - | 60,108 | Feb 14, 2023, 08:59 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Hunter C. Smith | Chief Financial Officer | Feb 14, 2023 | Sale | $26.87 | 702 | 18,863 | 59,406 | Feb 14, 2023, 08:59 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Hunter C. Smith | Chief Financial Officer | Feb 09, 2023 | Sale | $27.51 | 1,413 | 38,872 | 57,764 | Feb 14, 2023, 07:08 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Hunter C. Smith | Chief Financial Officer | Feb 09, 2023 | Option/RSU Exercise | - | 4,063 | - | 59,177 | Feb 13, 2023, 05:03 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Hunter C. Smith | Chief Financial Officer | Feb 09, 2023 | Sale | $27.66 | 1,398 | 38,669 | 57,779 | Feb 13, 2023, 05:03 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Hunter C. Smith | Chief Financial Officer | Dec 23, 2022 | Gift | - | 2,500 | - | 55,114 | Dec 29, 2022, 04:31 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Hunter C. Smith | Chief Financial Officer | Jun 30, 2022 | Option/RSU Exercise | - | 25,000 | - | 65,161 | Jul 06, 2022, 06:08 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Hunter C. Smith | Chief Financial Officer | Jul 01, 2022 | Sale | $4.08 | 7,547 | 30,792 | 57,614 | Jul 06, 2022, 06:08 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Hunter C. Smith | Chief Financial Officer | Feb 11, 2022 | Option/RSU Exercise | - | 2,344 | - | 40,994 | Feb 15, 2022, 07:31 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Hunter C. Smith | Chief Financial Officer | Feb 15, 2022 | Sale | $6.10 | 833 | 5,081 | 40,161 | Feb 15, 2022, 07:31 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Hunter C. Smith | Chief Financial Officer | Apr 21, 2021 | Option/RSU Exercise | $6.88 | 5,000 | 34,400 | 38,650 | Apr 23, 2021, 06:08 AM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Hunter C. Smith | Chief Financial Officer | Jan 19, 2021 | Option/RSU Exercise | $6.88 | 4,000 | 27,520 | 33,650 | Jan 20, 2021, 04:05 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Hunter C. Smith | CFO and Interim CEO | Mar 30, 2020 | Option/RSU Exercise | $6.88 | 3,900 | 26,832 | 29,650 | Mar 31, 2020, 06:00 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Hunter C. Smith | Chief Financial Officer | Mar 13, 2020 | Option/RSU Exercise | $6.88 | 3,500 | 24,080 | 25,750 | Mar 16, 2020, 04:16 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Hunter C. Smith | Chief Financial Officer | Jan 28, 2020 | Option/RSU Exercise | $6.88 | 6,250 | 43,000 | 22,250 | Jan 29, 2020, 04:00 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Hunter C. Smith | Chief Financial Officer | Jul 11, 2019 | Option/RSU Exercise | $6.88 | 10,000 | 68,800 | 16,000 | Jul 15, 2019, 04:01 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Hunter C. Smith | Chief Financial Officer | Jan 31, 2019 | Option/RSU Exercise | $6.88 | 3,000 | 20,640 | 6,000 | Feb 04, 2019, 04:01 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Hunter C. Smith | Chief Financial Officer | Sep 05, 2018 | Option/RSU Exercise | $6.88 | 3,000 | 20,640 | 3,000 | Sep 06, 2018, 04:02 PM |
