| GRCE | | Grace Therapeutics, Inc. | Opaleye Management . Inc | 10% Owner | Aug 14, 2026 | Buy | $2.09 | 11,608 | 24,206 | 2,760,000 | Aug 19, 2026, 07:44 AM |
| SLGL | | Sol-Gel Technologies Ltd. | Opaleye Management . Inc | 10% Owner | Aug 12, 2026 | Buy | $71.50 | 951 | 67,997 | 494,887 | Aug 14, 2026, 04:05 PM |
| ACOG | | Alpha Cognition Inc. | Opaleye Management . Inc | 10% Owner | Jul 31, 2026 | Buy | $7.92 | 2,900 | 22,976 | 2,998,223 | Aug 04, 2026, 04:50 PM |
| ACOG | | Alpha Cognition Inc. | Opaleye Management . Inc | 10% Owner | Aug 03, 2026 | Buy | $8.00 | 50,000 | 400,000 | 3,048,223 | Aug 04, 2026, 04:50 PM |
| ACOG | | Alpha Cognition Inc. | Opaleye Management . Inc | 10% Owner | Jul 24, 2026 | Buy | $7.90 | 130 | 1,027 | 2,995,323 | Jul 28, 2026, 04:05 PM |
| ACOG | | Alpha Cognition Inc. | Opaleye Management . Inc | 10% Owner | Jul 22, 2026 | Buy | $7.83 | 140,237 | 1,098,575 | 2,945,344 | Jul 24, 2026, 04:05 PM |
| ACOG | | Alpha Cognition Inc. | Opaleye Management . Inc | 10% Owner | Jul 23, 2026 | Buy | $7.80 | 49,849 | 388,588 | 2,995,193 | Jul 24, 2026, 04:05 PM |
| ACOG | | Alpha Cognition Inc. | Opaleye Management . Inc | 10% Owner | Jul 22, 2026 | Buy | $7.83 | 10,000 | 78,337 | 100,000 | Jul 24, 2026, 04:05 PM |
| ETON | | Eton Pharmaceuticals, Inc. | Opaleye Management . Inc | 10% Owner | Jul 14, 2026 | Sale | $37.54 | 13,315 | 499,886 | 40,000 | Jul 17, 2026, 07:12 PM |
| ETON | | Eton Pharmaceuticals, Inc. | Opaleye Management . Inc | 10% Owner | Jul 14, 2026 | Sale | $37.54 | 15,000 | 563,146 | 2,665,000 | Jul 17, 2026, 07:12 PM |
| ETON | | Eton Pharmaceuticals, Inc. | Opaleye Management . Inc | 10% Owner | Jul 14, 2026 | Sale | $37.54 | 13,315 | 499,886 | 40,000 | Jul 16, 2026, 05:14 PM |
| ETON | | Eton Pharmaceuticals, Inc. | Opaleye Management . Inc | 10% Owner | Jul 14, 2026 | Sale | $37.54 | 15,000 | 563,146 | 2,665,000 | Jul 16, 2026, 05:14 PM |
| SLGL | | Sol-Gel Technologies Ltd. | Opaleye Management . Inc | 10% Owner | Jul 13, 2026 | Buy | $73.89 | 775 | 57,263 | 493,016 | Jul 15, 2026, 04:05 PM |
| SLGL | | Sol-Gel Technologies Ltd. | Opaleye Management . Inc | 10% Owner | Jul 14, 2026 | Buy | $73.43 | 920 | 67,556 | 493,936 | Jul 15, 2026, 04:05 PM |
| SLGL | | Sol-Gel Technologies Ltd. | Opaleye Management . Inc | 10% Owner | Jul 08, 2026 | Buy | $73.69 | 300 | 22,107 | 492,012 | Jul 10, 2026, 04:41 PM |
| SLGL | | Sol-Gel Technologies Ltd. | Opaleye Management . Inc | 10% Owner | Jul 10, 2026 | Buy | $73.95 | 229 | 16,935 | 492,241 | Jul 10, 2026, 04:41 PM |
| ETON | | Eton Pharmaceuticals, Inc. | Opaleye Management . Inc | 10% Owner | Jul 07, 2026 | Sale | $38.37 | 20,000 | 767,456 | 2,680,000 | Jul 07, 2026, 06:29 PM |
| ETON | | Eton Pharmaceuticals, Inc. | Opaleye Management . Inc | 10% Owner | Jul 02, 2026 | Sale | $37.39 | 25,000 | 934,628 | 60,000 | Jul 07, 2026, 06:29 PM |
| ETON | | Eton Pharmaceuticals, Inc. | Opaleye Management . Inc | 10% Owner | Jul 02, 2026 | Sale | $37.39 | 65,000 | 2,430,032 | 2,710,000 | Jul 07, 2026, 06:29 PM |
| ETON | | Eton Pharmaceuticals, Inc. | Opaleye Management . Inc | 10% Owner | Jul 06, 2026 | Sale | $38.00 | 10,000 | 380,000 | 2,700,000 | Jul 07, 2026, 06:29 PM |
| ETON | | Eton Pharmaceuticals, Inc. | Opaleye Management . Inc | 10% Owner | Jul 07, 2026 | Sale | $38.37 | 6,685 | 256,522 | 53,315 | Jul 07, 2026, 06:29 PM |
| SLGL | | Sol-Gel Technologies Ltd. | Opaleye Management . Inc | 10% Owner | Jul 01, 2026 | Buy | $71.99 | 312 | 22,461 | 490,312 | Jul 02, 2026, 06:11 PM |
| SLGL | | Sol-Gel Technologies Ltd. | Opaleye Management . Inc | 10% Owner | Jul 02, 2026 | Buy | $71.97 | 1,400 | 100,759 | 491,712 | Jul 02, 2026, 06:11 PM |
| ACOG | | Alpha Cognition Inc. | Opaleye Management . Inc | 10% Owner | Jun 25, 2026 | Buy | $6.50 | 197 | 1,281 | 2,652,771 | Jun 29, 2026, 04:05 PM |
| ACOG | | Alpha Cognition Inc. | Opaleye Management . Inc | 10% Owner | Jun 26, 2026 | Buy | $6.40 | 152,336 | 975,209 | 2,805,107 | Jun 29, 2026, 04:05 PM |
| ACOG | | Alpha Cognition Inc. | Opaleye Management . Inc | 10% Owner | Jun 11, 2026 | Buy | $5.91 | 2,862 | 16,901 | 2,647,751 | Jun 15, 2026, 08:10 PM |
| ACOG | | Alpha Cognition Inc. | Opaleye Management . Inc | 10% Owner | Jun 12, 2026 | Buy | $5.93 | 273 | 1,619 | 2,648,024 | Jun 15, 2026, 08:10 PM |
| ACOG | | Alpha Cognition Inc. | Opaleye Management . Inc | 10% Owner | Jun 15, 2026 | Buy | $5.99 | 4,550 | 27,253 | 2,652,574 | Jun 15, 2026, 08:10 PM |
| ACOG | | Alpha Cognition Inc. | Opaleye Management . Inc | 10% Owner | Jun 09, 2026 | Buy | $5.98 | 24,856 | 148,534 | 2,639,017 | Jun 11, 2026, 04:05 PM |
| ACOG | | Alpha Cognition Inc. | Opaleye Management . Inc | 10% Owner | Jun 10, 2026 | Buy | $5.99 | 5,872 | 35,157 | 2,644,889 | Jun 11, 2026, 04:05 PM |
| ACOG | | Alpha Cognition Inc. | Opaleye Management . Inc | 10% Owner | Jun 05, 2026 | Buy | $5.83 | 10,054 | 58,596 | 2,614,161 | Jun 09, 2026, 04:05 PM |
| ACOG | | Alpha Cognition Inc. | Opaleye Management . Inc | 10% Owner | May 28, 2026 | Buy | $5.83 | 2,000 | 11,664 | 2,533,530 | May 29, 2026, 07:21 PM |
| ACOG | | Alpha Cognition Inc. | Opaleye Management . Inc | 10% Owner | May 29, 2026 | Buy | $5.90 | 70,577 | 416,397 | 2,604,107 | May 29, 2026, 07:21 PM |
| ACOG | | Alpha Cognition Inc. | Opaleye Management . Inc | 10% Owner | May 27, 2026 | Buy | $5.73 | 1,161 | 6,653 | 2,531,530 | May 29, 2026, 07:21 PM |
| ACOG | | Alpha Cognition Inc. | Opaleye Management . Inc | 10% Owner | May 20, 2026 | Buy | $5.89 | 8,431 | 49,659 | 2,514,424 | May 22, 2026, 04:05 PM |
| ACOG | | Alpha Cognition Inc. | Opaleye Management . Inc | 10% Owner | May 21, 2026 | Buy | $5.70 | 15,945 | 90,886 | 2,530,369 | May 22, 2026, 04:05 PM |
| SLGL | | Sol-Gel Technologies Ltd. | Opaleye Management . Inc | 10% Owner | May 20, 2026 | Buy | $64.43 | 1,563 | 100,712 | 490,000 | May 22, 2026, 04:05 PM |
| ACOG | | Alpha Cognition Inc. | Opaleye Management . Inc | 10% Owner | May 15, 2026 | Buy | $5.83 | 16,648 | 96,986 | 2,488,598 | May 19, 2026, 04:05 PM |
| ACOG | | Alpha Cognition Inc. | Opaleye Management . Inc | 10% Owner | May 18, 2026 | Buy | $5.69 | 17,395 | 99,023 | 2,505,993 | May 19, 2026, 04:05 PM |
| SLGL | | Sol-Gel Technologies Ltd. | Opaleye Management . Inc | 10% Owner | May 12, 2026 | Buy | $67.98 | 1,500 | 101,975 | 486,500 | May 14, 2026, 04:05 PM |
| SLGL | | Sol-Gel Technologies Ltd. | Opaleye Management . Inc | 10% Owner | May 13, 2026 | Buy | $66.87 | 1,937 | 129,527 | 488,437 | May 14, 2026, 04:05 PM |
| SNWV | | SANUWAVE Health, Inc. | Opaleye Management . Inc | 10% Owner | Apr 30, 2026 | Sale | $16.15 | 24,000 | 387,624 | 863,650 | May 04, 2026, 04:05 PM |
| SNWV | | SANUWAVE Health, Inc. | Opaleye Management . Inc | 10% Owner | May 01, 2026 | Sale | $16.11 | 500 | 8,055 | 5,000 | May 04, 2026, 04:05 PM |
| SNWV | | SANUWAVE Health, Inc. | Opaleye Management . Inc | 10% Owner | May 01, 2026 | Sale | $16.11 | 10,081 | 162,410 | 853,569 | May 04, 2026, 04:05 PM |
| SNWV | | SANUWAVE Health, Inc. | Opaleye Management . Inc | 10% Owner | Apr 30, 2026 | Sale | $16.15 | 1,000 | 16,151 | 5,500 | May 04, 2026, 04:05 PM |
| SNWV | | SANUWAVE Health, Inc. | Opaleye Management . Inc | 10% Owner | Apr 28, 2026 | Sale | $18.47 | 2,500 | 46,168 | 7,500 | Apr 30, 2026, 04:10 PM |
| SNWV | | SANUWAVE Health, Inc. | Opaleye Management . Inc | 10% Owner | Apr 28, 2026 | Sale | $18.47 | 43,788 | 808,650 | 911,010 | Apr 30, 2026, 04:10 PM |
| SNWV | | SANUWAVE Health, Inc. | Opaleye Management . Inc | 10% Owner | Apr 29, 2026 | Sale | $17.25 | 1,000 | 17,248 | 6,500 | Apr 30, 2026, 04:10 PM |
| SNWV | | SANUWAVE Health, Inc. | Opaleye Management . Inc | 10% Owner | Apr 29, 2026 | Sale | $17.25 | 23,360 | 402,904 | 887,650 | Apr 30, 2026, 04:10 PM |
| SNWV | | SANUWAVE Health, Inc. | Opaleye Management . Inc | 10% Owner | Apr 17, 2026 | Sale | $20.46 | 5,000 | 102,305 | 10,000 | Apr 21, 2026, 06:17 PM |
| SNWV | | SANUWAVE Health, Inc. | Opaleye Management . Inc | 10% Owner | Apr 17, 2026 | Sale | $20.46 | 11,267 | 230,535 | 955,000 | Apr 21, 2026, 06:17 PM |
| SNWV | | SANUWAVE Health, Inc. | Opaleye Management . Inc | 10% Owner | Apr 21, 2026 | Sale | $20.50 | 202 | 4,142 | 954,798 | Apr 21, 2026, 06:17 PM |
| ACOG | | Alpha Cognition Inc. | Opaleye Management . Inc | 10% Owner | Mar 27, 2026 | Buy | $5.08 | 10,000 | 50,792 | 2,470,000 | Mar 31, 2026, 04:05 PM |
| ACOG | | Alpha Cognition Inc. | Opaleye Management . Inc | 10% Owner | Mar 30, 2026 | Buy | $4.99 | 1,850 | 9,227 | 2,471,850 | Mar 31, 2026, 04:05 PM |
| ACOG | | Alpha Cognition Inc. | Opaleye Management . Inc | 10% Owner | Mar 26, 2026 | Buy | $5.28 | 7,319 | 38,675 | 2,460,000 | Mar 26, 2026, 06:57 PM |
| ACOG | | Alpha Cognition Inc. | Opaleye Management . Inc | 10% Owner | Mar 24, 2026 | Buy | $5.59 | 4,182 | 23,377 | 2,444,100 | Mar 26, 2026, 06:57 PM |
| ACOG | | Alpha Cognition Inc. | Opaleye Management . Inc | 10% Owner | Mar 25, 2026 | Buy | $5.43 | 8,581 | 46,579 | 2,452,681 | Mar 26, 2026, 06:57 PM |
| SLGL | | Sol-Gel Technologies Ltd. | Opaleye Management . Inc | 10% Owner | Mar 24, 2026 | Buy | $72.00 | 5,000 | 360,000 | 15,000 | Mar 24, 2026, 04:05 PM |
| SLGL | | Sol-Gel Technologies Ltd. | Opaleye Management . Inc | 10% Owner | Mar 24, 2026 | Buy | $72.00 | 34,665 | 2,495,880 | 485,000 | Mar 24, 2026, 04:05 PM |
| ACOG | | Alpha Cognition Inc. | Opaleye Management . Inc | 10% Owner | Mar 19, 2026 | Buy | $5.71 | 2,094 | 11,950 | 2,439,918 | Mar 20, 2026, 04:54 PM |
| ACOG | | Alpha Cognition Inc. | Opaleye Management . Inc | 10% Owner | Mar 18, 2026 | Buy | $5.75 | 2,481 | 14,263 | 2,437,824 | Mar 20, 2026, 04:54 PM |
| ACOG | | Alpha Cognition Inc. | Opaleye Management . Inc | 10% Owner | Mar 16, 2026 | Buy | $5.78 | 1,331 | 7,696 | 2,435,343 | Mar 18, 2026, 06:55 PM |
| ACOG | | Alpha Cognition Inc. | Opaleye Management . Inc | 10% Owner | Mar 12, 2026 | Buy | $5.85 | 5,708 | 33,416 | 2,426,654 | Mar 13, 2026, 06:43 PM |
| ACOG | | Alpha Cognition Inc. | Opaleye Management . Inc | 10% Owner | Mar 13, 2026 | Buy | $5.75 | 7,358 | 42,286 | 2,434,012 | Mar 13, 2026, 06:43 PM |
| ACOG | | Alpha Cognition Inc. | Opaleye Management . Inc | 10% Owner | Mar 05, 2026 | Buy | $5.80 | 42,023 | 243,633 | 2,416,867 | Mar 06, 2026, 04:05 PM |
| ACOG | | Alpha Cognition Inc. | Opaleye Management . Inc | 10% Owner | Mar 04, 2026 | Buy | $5.81 | 19,795 | 115,001 | 2,374,844 | Mar 06, 2026, 04:05 PM |
| ACOG | | Alpha Cognition Inc. | Opaleye Management . Inc | 10% Owner | Mar 05, 2026 | Buy | $5.80 | 5,000 | 28,988 | 90,000 | Mar 06, 2026, 04:05 PM |
| HROW | | HARROW, INC. | Opaleye Management . Inc | 10% Owner | Mar 03, 2026 | Sale | $39.15 | 59,000 | 2,309,992 | 3,756,000 | Mar 05, 2026, 04:05 PM |
| HROW | | HARROW, INC. | Opaleye Management . Inc | 10% Owner | Mar 04, 2026 | Sale | $39.67 | 4,263 | 169,122 | 59,428 | Mar 05, 2026, 04:05 PM |
| HROW | | HARROW, INC. | Opaleye Management . Inc | 10% Owner | Mar 04, 2026 | Sale | $39.67 | 134,000 | 5,316,061 | 3,622,000 | Mar 05, 2026, 04:05 PM |
| HROW | | HARROW, INC. | Opaleye Management . Inc | 10% Owner | Mar 03, 2026 | Sale | $39.15 | 1,309 | 51,250 | 63,691 | Mar 05, 2026, 04:05 PM |
| HROW | | HARROW, INC. | Opaleye Management . Inc | 10% Owner | Feb 27, 2026 | Sale | $54.18 | 5,000 | 270,900 | 65,000 | Mar 03, 2026, 04:05 PM |
| ACOG | | Alpha Cognition Inc. | Opaleye Management . Inc | 10% Owner | Feb 23, 2026 | Buy | $5.89 | 95,819 | 564,594 | 2,230,819 | Feb 24, 2026, 05:52 PM |
| ACOG | | Alpha Cognition Inc. | Opaleye Management . Inc | 10% Owner | Feb 24, 2026 | Buy | $5.80 | 5,000 | 29,002 | 80,000 | Feb 24, 2026, 05:52 PM |
| ACOG | | Alpha Cognition Inc. | Opaleye Management . Inc | 10% Owner | Feb 24, 2026 | Buy | $5.80 | 53,591 | 310,849 | 2,284,410 | Feb 24, 2026, 05:52 PM |
| ACOG | | Alpha Cognition Inc. | Opaleye Management . Inc | 10% Owner | Feb 20, 2026 | Buy | $5.84 | 2,819 | 16,466 | 70,819 | Feb 24, 2026, 05:52 PM |
| ACOG | | Alpha Cognition Inc. | Opaleye Management . Inc | 10% Owner | Feb 20, 2026 | Buy | $5.84 | 10,000 | 58,411 | 2,135,000 | Feb 24, 2026, 05:52 PM |
| ACOG | | Alpha Cognition Inc. | Opaleye Management . Inc | 10% Owner | Feb 23, 2026 | Buy | $5.89 | 4,181 | 24,636 | 75,000 | Feb 24, 2026, 05:52 PM |
| SLGL | | Sol-Gel Technologies Ltd. | Opaleye Management . Inc | 10% Owner | Feb 02, 2026 | Buy | $58.00 | 100 | 5,800 | 450,044 | Feb 18, 2026, 12:59 PM |
| SLGL | | Sol-Gel Technologies Ltd. | Opaleye Management . Inc | 10% Owner | Feb 02, 2026 | Buy | $58.00 | 100 | 5,800 | 450,944 | Feb 04, 2026, 04:05 PM |
| SLGL | | Sol-Gel Technologies Ltd. | Opaleye Management . Inc | 10% Owner | Jan 27, 2026 | Buy | $57.05 | 100 | 5,705 | 449,944 | Jan 29, 2026, 04:16 PM |
| SLGL | | Sol-Gel Technologies Ltd. | Opaleye Management . Inc | 10% Owner | Jan 22, 2026 | Buy | $56.57 | 2,173 | 122,922 | 448,693 | Jan 23, 2026, 05:42 PM |
| SLGL | | Sol-Gel Technologies Ltd. | Opaleye Management . Inc | 10% Owner | Jan 23, 2026 | Buy | $55.98 | 1,151 | 64,434 | 449,844 | Jan 23, 2026, 05:42 PM |
| HROW | | HARROW, INC. | Opaleye Management . Inc | 10% Owner | Jan 06, 2026 | Sale | $53.35 | 20,000 | 1,066,914 | 70,000 | Jan 08, 2026, 04:05 PM |
| SLGL | | Sol-Gel Technologies Ltd. | Opaleye Management . Inc | 10% Owner | Jan 02, 2026 | Buy | $41.92 | 2,394 | 100,348 | 447,133 | Jan 06, 2026, 04:05 PM |
| SLGL | | Sol-Gel Technologies Ltd. | Opaleye Management . Inc | 10% Owner | Jan 05, 2026 | Buy | $42.98 | 198 | 8,510 | 447,331 | Jan 06, 2026, 04:05 PM |
| SLGL | | Sol-Gel Technologies Ltd. | Opaleye Management . Inc | 10% Owner | Dec 29, 2025 | Buy | $41.85 | 8,638 | 361,534 | 386,073 | Dec 31, 2025, 05:45 PM |
| SLGL | | Sol-Gel Technologies Ltd. | Opaleye Management . Inc | 10% Owner | Dec 30, 2025 | Buy | $41.99 | 35,169 | 1,476,627 | 421,242 | Dec 31, 2025, 05:45 PM |
| SLGL | | Sol-Gel Technologies Ltd. | Opaleye Management . Inc | 10% Owner | Dec 31, 2025 | Buy | $41.99 | 22,497 | 944,744 | 443,739 | Dec 31, 2025, 05:45 PM |
| SLGL | | Sol-Gel Technologies Ltd. | Opaleye Management . Inc | 10% Owner | Dec 23, 2025 | Buy | $41.66 | 260 | 10,832 | 375,809 | Dec 29, 2025, 04:05 PM |
| SLGL | | Sol-Gel Technologies Ltd. | Opaleye Management . Inc | 10% Owner | Dec 26, 2025 | Buy | $41.68 | 1,626 | 67,765 | 377,435 | Dec 29, 2025, 04:05 PM |
| SLGL | | Sol-Gel Technologies Ltd. | Opaleye Management . Inc | 10% Owner | Dec 22, 2025 | Buy | $41.15 | 1,019 | 41,936 | 375,549 | Dec 29, 2025, 04:05 PM |
| SLGL | | Sol-Gel Technologies Ltd. | Opaleye Management . Inc | 10% Owner | Dec 17, 2025 | Buy | $40.37 | 2,735 | 110,412 | 374,530 | Dec 19, 2025, 04:05 PM |
| SLGL | | Sol-Gel Technologies Ltd. | Opaleye Management . Inc | 10% Owner | Dec 12, 2025 | Buy | $40.00 | 87 | 3,480 | 371,795 | Dec 16, 2025, 04:05 PM |
| CDXS | | CODEXIS, INC. | Opaleye Management . Inc | 10% Owner | Dec 01, 2025 | Sale | $1.67 | 8,533 | 14,229 | 179,989 | Dec 15, 2025, 06:06 AM |
| CDXS | | CODEXIS, INC. | Opaleye Management . Inc | 10% Owner | Dec 01, 2025 | Sale | $1.67 | 245,000 | 408,538 | 9,955,000 | Dec 15, 2025, 06:06 AM |
| CDXS | | CODEXIS, INC. | Opaleye Management . Inc | 10% Owner | Nov 26, 2025 | Sale | $1.74 | 5,000 | 8,706 | 191,012 | Dec 15, 2025, 06:06 AM |
| CDXS | | CODEXIS, INC. | Opaleye Management . Inc | 10% Owner | Nov 26, 2025 | Sale | $1.74 | 148,318 | 258,266 | 10,305,000 | Dec 15, 2025, 06:06 AM |
| CDXS | | CODEXIS, INC. | Opaleye Management . Inc | 10% Owner | Nov 28, 2025 | Sale | $1.75 | 2,490 | 4,358 | 188,522 | Dec 15, 2025, 06:06 AM |
| CDXS | | CODEXIS, INC. | Opaleye Management . Inc | 10% Owner | Nov 28, 2025 | Sale | $1.75 | 105,000 | 183,750 | 10,200,000 | Dec 15, 2025, 06:06 AM |
