| Symbol | Company | Owner | Relationship | Date | Transaction | Cost | # Shares | Value ($) | Total Shares | Filing | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| INVA | Innoviva, Inc. | DENNER ALEXANDER J | 10% Owner | Jun 06, 2023 | Buy | $13.05 | 8,000 | 104,384 | 7,215,000 | Jun 07, 2023, 08:10 PM | |
| INVA | Innoviva, Inc. | DENNER ALEXANDER J | 10% Owner | Jun 05, 2023 | Buy | $13.04 | 7,000 | 91,297 | 7,207,000 | Jun 07, 2023, 08:10 PM | |
| INVA | Innoviva, Inc. | DENNER ALEXANDER J | 10% Owner | May 25, 2023 | Buy | $13.09 | 50,000 | 654,330 | 7,050,000 | May 30, 2023, 07:01 PM | |
| INVA | Innoviva, Inc. | DENNER ALEXANDER J | 10% Owner | May 26, 2023 | Buy | $13.12 | 30,000 | 393,729 | 7,080,000 | May 30, 2023, 07:01 PM | |
| INVA | Innoviva, Inc. | DENNER ALEXANDER J | 10% Owner | May 30, 2023 | Buy | $13.01 | 120,000 | 1,560,648 | 7,200,000 | May 30, 2023, 07:01 PM | |
| INVA | Innoviva, Inc. | DENNER ALEXANDER J | 10% Owner | May 19, 2023 | Buy | $13.48 | 36,000 | 485,147 | 7,000,000 | May 19, 2023, 09:12 PM | |
| INVA | Innoviva, Inc. | DENNER ALEXANDER J | 10% Owner | May 17, 2023 | Buy | $13.07 | 50,000 | 653,690 | 6,954,000 | May 19, 2023, 09:12 PM | |
| INVA | Innoviva, Inc. | DENNER ALEXANDER J | 10% Owner | May 18, 2023 | Buy | $13.05 | 10,000 | 130,538 | 6,964,000 | May 19, 2023, 09:12 PM | |
| INVA | Innoviva, Inc. | DENNER ALEXANDER J | 10% Owner | May 17, 2023 | Buy | $13.07 | 50,000 | 653,690 | 6,954,000 | May 19, 2023, 08:00 PM | |
| INVA | Innoviva, Inc. | DENNER ALEXANDER J | 10% Owner | May 18, 2023 | Buy | $13.05 | 10,000 | 130,538 | 6,964,000 | May 19, 2023, 08:00 PM | |
| INVA | Innoviva, Inc. | DENNER ALEXANDER J | 10% Owner | May 11, 2023 | Buy | $12.34 | 290,000 | 3,577,411 | 6,904,000 | May 15, 2023, 09:09 PM | |
| IRWD | IRONWOOD PHARMACEUTICALS INC | DENNER ALEXANDER J | Director | Mar 10, 2021 | Buy | $10.54 | 75,000 | 790,500 | 16,390,000 | Mar 10, 2021, 07:06 PM | |
| IRWD | IRONWOOD PHARMACEUTICALS INC | DENNER ALEXANDER J | Director | Mar 08, 2021 | Buy | $10.30 | 150,000 | 1,545,000 | 16,315,000 | Mar 10, 2021, 07:06 PM | |
| IRWD | IRONWOOD PHARMACEUTICALS INC | DENNER ALEXANDER J | Director | Mar 03, 2021 | Buy | $10.02 | 350,000 | 3,507,000 | 15,740,000 | Mar 05, 2021, 07:19 PM | |
| IRWD | IRONWOOD PHARMACEUTICALS INC | DENNER ALEXANDER J | Director | Mar 04, 2021 | Buy | $10.00 | 250,000 | 2,500,000 | 15,990,000 | Mar 05, 2021, 07:19 PM | |
| IRWD | IRONWOOD PHARMACEUTICALS INC | DENNER ALEXANDER J | Director | Mar 05, 2021 | Buy | $10.01 | 175,000 | 1,751,750 | 16,165,000 | Mar 05, 2021, 07:19 PM | |
| IRWD | IRONWOOD PHARMACEUTICALS INC | DENNER ALEXANDER J | Director | Mar 02, 2021 | Buy | $9.56 | 500,000 | 4,780,000 | 15,390,000 | Mar 02, 2021, 08:18 PM | |
| IRWD | IRONWOOD PHARMACEUTICALS INC | DENNER ALEXANDER J | Director | Feb 26, 2021 | Buy | $9.20 | 505,100 | 4,646,920 | 14,545,100 | Mar 02, 2021, 08:18 PM | |
| IRWD | IRONWOOD PHARMACEUTICALS INC | DENNER ALEXANDER J | Director | Mar 01, 2021 | Buy | $9.60 | 344,900 | 3,311,040 | 14,890,000 | Mar 02, 2021, 08:18 PM | |
| ITRM | Iterum Therapeutics plc | DENNER ALEXANDER J | 10% Owner | Feb 11, 2021 | Sale | $2.59 | 10,000,000 | 25,899,999 | 10,619,949 | Feb 12, 2021, 08:22 PM | |
| ITRM | Iterum Therapeutics plc | DENNER ALEXANDER J | 10% Owner | Feb 12, 2021 | Sale | $2.27 | 10,619,949 | 24,107,284 | 0 | Feb 12, 2021, 08:22 PM | |
| MDCO | MEDICINES CO /DE | DENNER ALEXANDER J | Director | Jun 28, 2019 | Buy | $33.00 | 50,000 | 1,650,000 | 4,202,000 | Jun 28, 2019, 08:19 PM | |
| MDCO | MEDICINES CO /DE | DENNER ALEXANDER J | Director | May 29, 2019 | Buy | $34.85 | 35,000 | 1,219,750 | 4,102,000 | May 31, 2019, 07:31 AM | |
| MDCO | MEDICINES CO /DE | DENNER ALEXANDER J | Director | May 30, 2019 | Buy | $34.81 | 50,000 | 1,740,500 | 4,152,000 | May 31, 2019, 07:31 AM | |
| MDCO | MEDICINES CO /DE | DENNER ALEXANDER J | Director | May 20, 2019 | Buy | $34.50 | 160,000 | 5,520,000 | 3,796,000 | May 22, 2019, 05:56 PM | |
| MDCO | MEDICINES CO /DE | DENNER ALEXANDER J | Director | May 21, 2019 | Buy | $33.95 | 132,000 | 4,481,400 | 3,928,000 | May 22, 2019, 05:56 PM | |
| MDCO | MEDICINES CO /DE | DENNER ALEXANDER J | Director | May 22, 2019 | Buy | $33.13 | 139,000 | 4,605,070 | 4,067,000 | May 22, 2019, 05:56 PM | |
| BIIB | BIOGEN INC. | DENNER ALEXANDER J | Director | Apr 30, 2019 | Buy | $229.25 | 50,342 | 11,540,904 | 575,000 | May 02, 2019, 05:06 PM | |
| BIIB | BIOGEN INC. | DENNER ALEXANDER J | Director | May 01, 2019 | Buy | $229.46 | 30,000 | 6,883,800 | 605,000 | May 02, 2019, 05:06 PM | |
| BIIB | BIOGEN INC. | DENNER ALEXANDER J | Director | May 02, 2019 | Buy | $231.24 | 38,000 | 8,787,120 | 643,000 | May 02, 2019, 05:06 PM | |
| MDCO | MEDICINES CO /DE | DENNER ALEXANDER J | Director | Mar 06, 2019 | Buy | $24.91 | 248,100 | 6,180,171 | 3,636,000 | Mar 08, 2019, 01:13 PM | |
| MDCO | MEDICINES CO /DE | DENNER ALEXANDER J | Director | Mar 05, 2019 | Buy | $26.07 | 181,900 | 4,742,133 | 3,387,900 | Mar 05, 2019, 05:14 PM | |
| MDCO | MEDICINES CO /DE | DENNER ALEXANDER J | Director | Mar 01, 2019 | Buy | $25.15 | 100,000 | 2,515,000 | 2,881,000 | Mar 05, 2019, 05:14 PM | |
| MDCO | MEDICINES CO /DE | DENNER ALEXANDER J | Director | Mar 04, 2019 | Buy | $25.45 | 325,000 | 8,271,250 | 3,206,000 | Mar 05, 2019, 05:14 PM | |
| BIIB | BIOGEN INC. | DENNER ALEXANDER J | Director | Jan 30, 2019 | Buy | $324.86 | 30,000 | 9,745,860 | 491,858 | Feb 01, 2019, 04:19 PM | |
| BIIB | BIOGEN INC. | DENNER ALEXANDER J | Director | Jan 31, 2019 | Buy | $330.52 | 25,800 | 8,527,391 | 517,658 | Feb 01, 2019, 04:19 PM | |
| BIIB | BIOGEN INC. | DENNER ALEXANDER J | Director | Feb 01, 2019 | Buy | $328.45 | 7,000 | 2,299,164 | 524,658 | Feb 01, 2019, 04:19 PM | |
| MDCO | MEDICINES CO /DE | DENNER ALEXANDER J | Director | Dec 20, 2018 | Buy | $17.89 | 10,000 | 178,900 | 2,781,000 | Dec 21, 2018, 07:30 AM | |
| MDCO | MEDICINES CO /DE | DENNER ALEXANDER J | Director | Dec 17, 2018 | Buy | $17.91 | 20,000 | 358,200 | 2,761,000 | Dec 18, 2018, 04:16 PM | |
| MDCO | MEDICINES CO /DE | DENNER ALEXANDER J | Director | Dec 18, 2018 | Buy | $18.18 | 10,000 | 181,800 | 2,771,000 | Dec 18, 2018, 04:16 PM | |
| MDCO | MEDICINES CO /DE | DENNER ALEXANDER J | Director | Dec 13, 2018 | Buy | $20.73 | 600,000 | 12,438,000 | 2,522,000 | Dec 17, 2018, 04:21 PM | |
| MDCO | MEDICINES CO /DE | DENNER ALEXANDER J | Director | Dec 14, 2018 | Buy | $18.97 | 219,000 | 4,154,430 | 2,741,000 | Dec 17, 2018, 04:21 PM | |
| BIIB | BIOGEN INC. | DENNER ALEXANDER J | Director | Apr 25, 2018 | Buy | $269.91 | 48,000 | 12,955,680 | 461,858 | Apr 27, 2018, 07:48 AM | |
| MDCO | MEDICINES CO /DE | DENNER ALEXANDER J | Director | Nov 29, 2017 | Buy | $30.03 | 170,000 | 5,105,100 | 1,922,000 | Nov 30, 2017, 07:30 AM | |
| BIIB | BIOGEN INC. | DENNER ALEXANDER J | Director | Nov 28, 2017 | Buy | $316.12 | 20,000 | 6,322,400 | 403,858 | Nov 30, 2017, 07:30 AM | |
| BIIB | BIOGEN INC. | DENNER ALEXANDER J | Director | Nov 29, 2017 | Buy | $319.84 | 10,000 | 3,198,400 | 413,858 | Nov 30, 2017, 07:30 AM | |
| APRI | APRICUS BIOSCIENCES, INC. | DENNER ALEXANDER J | 10% Owner | Aug 31, 2017 | Buy | $1.63 | 6,104 | 9,950 | 1,447,906 | Sep 01, 2017, 04:26 PM | |
| MDCO | MEDICINES CO /DE | DENNER ALEXANDER J | Director | Aug 31, 2017 | Option Exercise | $36.69 | 7,146 | 262,187 | 1,752,000 | Aug 31, 2017, 09:50 PM | |
| BIVV | Bioverativ Inc. | DENNER ALEXANDER J | Director | Aug 31, 2017 | Option Exercise | $56.69 | 932 | 52,835 | 1,165,000 | Aug 31, 2017, 09:47 PM | |
| BIIB | BIOGEN INC. | DENNER ALEXANDER J | Director | Aug 31, 2017 | Option Exercise | $316.56 | 933 | 295,350 | 383,858 | Aug 31, 2017, 09:45 PM | |
| BIVV | Bioverativ Inc. | DENNER ALEXANDER J | Director | May 30, 2017 | Buy | $55.93 | 90,000 | 5,033,475 | 1,165,000 | Jun 01, 2017, 05:16 PM | |
| BIVV | Bioverativ Inc. | DENNER ALEXANDER J | Director | May 24, 2017 | Buy | $54.16 | 340,000 | 18,414,400 | 495,000 | May 26, 2017, 07:20 PM | |
| BIVV | Bioverativ Inc. | DENNER ALEXANDER J | Director | May 25, 2017 | Buy | $54.98 | 130,000 | 7,147,907 | 625,000 | May 26, 2017, 07:20 PM | |
| BIVV | Bioverativ Inc. | DENNER ALEXANDER J | Director | May 26, 2017 | Buy | $57.21 | 450,000 | 25,745,130 | 1,075,000 | May 26, 2017, 07:20 PM | |
| BIIB | BIOGEN INC. | DENNER ALEXANDER J | Director | Apr 27, 2017 | Buy | $278.50 | 73,858 | 20,569,476 | 383,858 | May 01, 2017, 05:47 PM | |
| BIVV | Bioverativ Inc. | DENNER ALEXANDER J | Director | Apr 17, 2017 | Option Exercise | $56.83 | 1,056 | 60,012 | 5,001 | Apr 17, 2017, 04:18 PM | |
| APRI | APRICUS BIOSCIENCES, INC. | DENNER ALEXANDER J | 10% Owner | Mar 03, 2016 | Buy | $0.88 | 6,647,728 | 5,850,001 | 14,479,053 | Mar 07, 2016, 05:33 PM | |
| APRI | APRICUS BIOSCIENCES, INC. | DENNER ALEXANDER J | 10% Owner | Jan 12, 2016 | Buy | $0.88 | 1,306,819 | 1,150,001 | 7,831,324 | Jan 14, 2016, 09:43 PM | |
| BIIB | BIOGEN INC. | DENNER ALEXANDER J | Director | Oct 23, 2015 | Buy | $276.77 | 100,000 | 27,676,999 | 310,000 | Oct 26, 2015, 07:03 PM | |
| BIIB | BIOGEN INC. | DENNER ALEXANDER J | Director | Oct 22, 2015 | Buy | $277.80 | 210,000 | 58,337,997 | 210,000 | Oct 26, 2015, 07:03 PM | |
| ARIA | ARIAD PHARMACEUTICALS INC | DENNER ALEXANDER J | Director | Aug 15, 2014 | Buy | $5.83 | 615,466 | 3,588,167 | 7,798,665 | Aug 19, 2014, 06:04 PM | |
| ARIA | ARIAD PHARMACEUTICALS INC | DENNER ALEXANDER J | Director | Aug 15, 2014 | Buy | $5.83 | 234,534 | 1,367,333 | 5,051,335 | Aug 19, 2014, 06:04 PM | |
| VVUS | VIVUS INC | DENNER ALEXANDER J | Director | Nov 08, 2013 | Buy | $8.52 | 417,068 | 3,553,420 | 2,424,167 | Nov 12, 2013, 05:08 PM | |
| VVUS | VIVUS INC | DENNER ALEXANDER J | Director | Nov 11, 2013 | Buy | $8.78 | 149,776 | 1,315,033 | 2,573,943 | Nov 12, 2013, 05:08 PM | |
| BIIB | BIOGEN IDEC INC. | DENNER ALEXANDER J | Director | Jun 14, 2013 | Sale | $212.00 | 2,900 | 614,800 | 6,325 | Jun 17, 2013, 03:46 PM | |
| BIIB | BIOGEN IDEC INC. | DENNER ALEXANDER J | Director | May 29, 2013 | Option Exercise | $53.43 | 3,000 | 160,290 | 7,920 | May 31, 2013, 12:26 PM | |
| BIIB | BIOGEN IDEC INC. | DENNER ALEXANDER J | Director | May 28, 2013 | Option Exercise | $53.43 | 37,975 | 2,029,004 | 39,920 | May 29, 2013, 05:15 PM | |
| BIIB | BIOGEN IDEC INC. | DENNER ALEXANDER J | Director | May 28, 2013 | Sale | $240.57 | 37,975 | 9,135,697 | 37,620 | May 29, 2013, 05:15 PM | |
| BIIB | BIOGEN IDEC INC. | DENNER ALEXANDER J | Director | Dec 26, 2012 | Sale | $148.89 | 3,989 | 593,914 | 8,911 | Dec 28, 2012, 10:15 AM | |
| BIIB | BIOGEN IDEC INC. | DENNER ALEXANDER J | Director | Dec 27, 2012 | Sale | $148.36 | 3,991 | 592,086 | 6,220 | Dec 28, 2012, 10:15 AM | |
| AMLN | AMYLIN PHARMACEUTICALS INC | DENNER ALEXANDER J | Director | Aug 08, 2012 | Option Exercise | $31.00 | 10,161 | 314,991 | 1,104 | Aug 10, 2012, 06:35 PM | |
| AMLN | AMYLIN PHARMACEUTICALS INC | DENNER ALEXANDER J | Director | Jan 17, 2012 | Sale | $11.59 | 1,832 | 21,233 | 7,161 | Jan 19, 2012, 04:45 PM |
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