| ALDX | | Aldeyra Therapeutics, Inc. | Perceptive Advisors LLC | 10% Owner | Jan 08, 2021 | Buy | $9.34 | 550,000 | 5,137,668 | 7,335,458 | Jan 11, 2021, 09:53 PM |
| SLDB | | Solid Biosciences Inc. | Perceptive Advisors LLC | Director | Dec 10, 2020 | Award/Grant | $3.70 | 4,054,054 | 15,000,000 | 10,803,857 | Dec 15, 2020, 08:21 PM |
| MGTX | | MeiraGTx Holdings plc | Perceptive Advisors LLC | Director | Nov 23, 2020 | Buy | $12.85 | 500,000 | 6,425,000 | 6,933,277 | Nov 24, 2020, 08:00 AM |
| ATHA | | Athira Pharma, Inc. | Perceptive Advisors LLC | 10% Owner | Sep 22, 2020 | Conversion | - | 1,644,785 | - | 2,055,981 | Sep 22, 2020, 07:11 PM |
| ATHA | | Athira Pharma, Inc. | Perceptive Advisors LLC | 10% Owner | Sep 22, 2020 | Buy | $17.00 | 1,058,824 | 18,000,008 | 3,114,805 | Sep 22, 2020, 07:11 PM |
| ALDX | | Aldeyra Therapeutics, Inc. | Perceptive Advisors LLC | 10% Owner | Jul 09, 2020 | Buy | $4.25 | 3,200,000 | 13,600,000 | 6,285,458 | Jul 13, 2020, 04:30 PM |
| LPTX | | LEAP THERAPEUTICS, INC. | Perceptive Advisors LLC | 10% Owner | Jun 22, 2020 | Buy | $2.00 | 1,750,000 | 3,500,000 | 8,476,496 | Jun 24, 2020, 07:00 PM |
| MNLO | | Menlo Therapeutics Inc. | Perceptive Advisors LLC | 10% Owner | Jun 09, 2020 | Buy | $1.85 | 2,702,702 | 4,999,999 | 22,876,410 | Jun 11, 2020, 07:33 PM |
| LYRA | | Lyra Therapeutics, Inc. | Perceptive Advisors LLC | Director | May 05, 2020 | Buy | $16.00 | 625,000 | 10,000,000 | 1,934,115 | May 29, 2020, 05:34 PM |
| LYRA | | Lyra Therapeutics, Inc. | Perceptive Advisors LLC | Director | May 05, 2020 | Conversion | - | 2,376,082 | - | 1,244,066 | May 06, 2020, 09:10 PM |
| LYRA | | Lyra Therapeutics, Inc. | Perceptive Advisors LLC | Director | May 05, 2020 | Tax Payment (Shares) | $16.00 | 259,346 | 4,149,536 | 1,309,115 | May 06, 2020, 09:10 PM |
| LYRA | | Lyra Therapeutics, Inc. | Perceptive Advisors LLC | Director | May 05, 2020 | ATM/ITM Option Exercise | $8.63 | 480,825 | 4,149,520 | 1,471,620 | May 06, 2020, 09:10 PM |
| CRNX | | Crinetics Pharmaceuticals, Inc. | Perceptive Advisors LLC | 10% Owner | Apr 17, 2020 | Buy | $14.00 | 1,071,428 | 14,999,992 | 3,659,381 | Apr 20, 2020, 08:30 AM |
| ADMA | | ADMA BIOLOGICS, INC. | Perceptive Advisors LLC | 10% Owner | Mar 19, 2020 | Buy | $2.10 | 500,000 | 1,050,000 | 16,584,802 | Mar 23, 2020, 08:30 AM |
| ADMA | | ADMA BIOLOGICS, INC. | Perceptive Advisors LLC | 10% Owner | Feb 11, 2020 | Buy | $3.50 | 4,563,700 | 15,972,950 | 16,084,802 | Feb 11, 2020, 08:02 AM |
| MGTX | | MeiraGTx Holdings plc | Perceptive Advisors LLC | Director | Aug 12, 2019 | Buy | $23.50 | 425,531 | 9,999,979 | 6,433,277 | Aug 20, 2019, 06:00 PM |
| SLDB | | Solid Biosciences Inc. | Perceptive Advisors LLC | Director | Jul 25, 2019 | Buy | $4.65 | 2,822,581 | 13,125,002 | 6,749,803 | Jul 29, 2019, 04:40 PM |
| ADMA | | ADMA BIOLOGICS, INC. | Perceptive Advisors LLC | 10% Owner | May 21, 2019 | Buy | $4.00 | 4,000,000 | 16,000,000 | 11,521,102 | May 23, 2019, 08:32 AM |
| FOLD | | AMICUS THERAPEUTICS INC | Perceptive Advisors LLC | 10% Owner | Sep 24, 2018 | Buy | $12.45 | 20,000 | 249,000 | 20,694,424 | Oct 05, 2018, 08:36 AM |
| FOLD | | AMICUS THERAPEUTICS INC | Perceptive Advisors LLC | 10% Owner | Oct 03, 2018 | Buy | $12.69 | 30,000 | 380,700 | 20,724,424 | Oct 05, 2018, 08:36 AM |
| FOLD | | AMICUS THERAPEUTICS INC | Perceptive Advisors LLC | 10% Owner | Sep 21, 2018 | Buy | $12.53 | 50,000 | 626,500 | 20,674,424 | Sep 25, 2018, 08:30 AM |
| FOLD | | AMICUS THERAPEUTICS INC | Perceptive Advisors LLC | 10% Owner | Sep 13, 2018 | Buy | $11.74 | 100,000 | 1,174,000 | 20,624,424 | Sep 17, 2018, 08:22 AM |
| FOLD | | AMICUS THERAPEUTICS INC | Perceptive Advisors LLC | 10% Owner | Sep 12, 2018 | Buy | $12.00 | 500,000 | 6,001,500 | 20,524,424 | Sep 14, 2018, 08:30 AM |
| CRNX | | Crinetics Pharmaceuticals, Inc. | Perceptive Advisors LLC | Director | Jul 18, 2018 | Buy | $21.30 | 307,648 | 6,552,902 | 307,648 | Aug 27, 2018, 06:12 PM |
| CRNX | | Crinetics Pharmaceuticals, Inc. | Perceptive Advisors LLC | Director | Jul 20, 2018 | Conversion | - | 1,880,305 | - | 2,187,953 | Aug 27, 2018, 06:12 PM |
| CRNX | | Crinetics Pharmaceuticals, Inc. | Perceptive Advisors LLC | Director | Jul 20, 2018 | Buy | $17.00 | 400,000 | 6,800,000 | 2,587,953 | Aug 27, 2018, 06:12 PM |
| VRCA | | Verrica Pharmaceuticals Inc. | Perceptive Advisors LLC | 10% Owner | Jun 19, 2018 | Buy | $15.00 | 1,000,000 | 15,000,000 | 3,410,412 | Aug 01, 2018, 09:50 PM |
| VRCA | | Verrica Pharmaceuticals Inc. | Perceptive Advisors LLC | 10% Owner | Jun 19, 2018 | Conversion | - | 2,410,412 | - | 2,410,412 | Aug 01, 2018, 09:50 PM |
| CRNX | | Crinetics Pharmaceuticals, Inc. | Perceptive Advisors LLC | Director | Jul 20, 2018 | Conversion | - | 1,880,305 | - | 1,880,305 | Jul 20, 2018, 05:19 PM |
| CRNX | | Crinetics Pharmaceuticals, Inc. | Perceptive Advisors LLC | Director | Jul 20, 2018 | Buy | $17.00 | 400,000 | 6,800,000 | 2,280,305 | Jul 20, 2018, 05:19 PM |
| MGTX | | MeiraGTx Holdings plc | Perceptive Advisors LLC | Director | Jun 08, 2018 | Buy | $15.22 | 50,000 | 761,000 | 3,370,065 | Jun 12, 2018, 04:05 PM |
| MGTX | | MeiraGTx Holdings plc | Perceptive Advisors LLC | Director | Jun 12, 2018 | Buy | $15.00 | 1,333,333 | 19,999,995 | 4,703,398 | Jun 12, 2018, 04:05 PM |
| FOLD | | AMICUS THERAPEUTICS INC | Perceptive Advisors LLC | 10% Owner | Mar 05, 2018 | Buy | $13.56 | 335,827 | 4,553,814 | 18,424,424 | Mar 07, 2018, 05:27 PM |
| FOLD | | AMICUS THERAPEUTICS INC | Perceptive Advisors LLC | 10% Owner | Mar 02, 2018 | Buy | $13.90 | 100,000 | 1,389,500 | 18,088,597 | Mar 06, 2018, 04:22 PM |
| FOLD | | AMICUS THERAPEUTICS INC | Perceptive Advisors LLC | 10% Owner | Mar 01, 2018 | Buy | $13.69 | 100,000 | 1,369,000 | 17,988,597 | Mar 05, 2018, 12:00 AM |
| SLDB | | Solid Biosciences Inc. | Perceptive Advisors LLC | Director | Jan 30, 2018 | Buy | $16.22 | 1,020,000 | 16,546,520 | 3,927,222 | Jan 30, 2018, 01:05 PM |
| ALDX | | Aldeyra Therapeutics, Inc. | Perceptive Advisors LLC | 10% Owner | Sep 19, 2017 | Buy | $7.25 | 200,000 | 1,450,000 | 3,085,458 | Sep 21, 2017, 08:45 AM |
| FOLD | | AMICUS THERAPEUTICS INC | Perceptive Advisors LLC | 10% Owner | Jul 13, 2017 | Buy | $12.25 | 1,500,000 | 18,375,000 | 17,888,597 | Jul 14, 2017, 08:30 AM |
| ALDX | | Aldeyra Therapeutics, Inc. | Perceptive Advisors LLC | 10% Owner | Jun 30, 2017 | Buy | $4.60 | 296,007 | 1,361,632 | 2,885,458 | Jul 05, 2017, 12:00 AM |
| ACRX | | ACELRX PHARMACEUTICALS INC | Perceptive Advisors LLC | 10% Owner | Jun 19, 2017 | Sale | $2.40 | 875,000 | 2,100,000 | 4,533,728 | Jun 21, 2017, 04:45 PM |
| ALDX | | Aldeyra Therapeutics, Inc. | Perceptive Advisors LLC | 10% Owner | Feb 14, 2017 | Buy | $4.50 | 893,025 | 4,018,613 | 2,589,451 | Feb 15, 2017, 08:45 AM |
| FOLD | | AMICUS THERAPEUTICS INC | Perceptive Advisors LLC | 10% Owner | Dec 30, 2016 | Buy | $4.96 | 94,750 | 470,055 | 16,293,847 | Jan 04, 2017, 02:25 PM |
| FOLD | | AMICUS THERAPEUTICS INC | Perceptive Advisors LLC | 10% Owner | Dec 29, 2016 | Buy | $4.85 | 94,750 | 459,917 | 16,293,847 | Dec 30, 2016, 08:45 AM |
| FOLD | | AMICUS THERAPEUTICS INC | Perceptive Advisors LLC | 10% Owner | Dec 28, 2016 | Buy | $4.91 | 47,375 | 232,706 | 16,199,097 | Dec 30, 2016, 08:45 AM |
| FOLD | | AMICUS THERAPEUTICS INC | Perceptive Advisors LLC | 10% Owner | Dec 23, 2016 | Buy | $4.81 | 85,275 | 410,050 | 16,151,722 | Dec 27, 2016, 10:57 AM |
| FOLD | | AMICUS THERAPEUTICS INC | Perceptive Advisors LLC | 10% Owner | Dec 22, 2016 | Buy | $4.51 | 189,500 | 854,835 | 16,066,447 | Dec 23, 2016, 08:31 AM |
| ACRX | | ACELRX PHARMACEUTICALS INC | Perceptive Advisors LLC | 10% Owner | Sep 28, 2016 | Sale | $3.96 | 119,300 | 472,380 | 5,483,610 | Sep 30, 2016, 04:32 PM |
| ACRX | | ACELRX PHARMACEUTICALS INC | Perceptive Advisors LLC | 10% Owner | Sep 29, 2016 | Sale | $3.88 | 97,200 | 377,117 | 5,386,410 | Sep 30, 2016, 04:32 PM |
| ACRX | | ACELRX PHARMACEUTICALS INC | Perceptive Advisors LLC | 10% Owner | Sep 15, 2016 | Sale | $3.70 | 392,850 | 1,452,811 | 5,718,833 | Sep 16, 2016, 04:37 PM |
| FOLD | | AMICUS THERAPEUTICS INC | Perceptive Advisors LLC | No longer a 10% Owner. | Aug 25, 2016 | Sale | $6.81 | 1,100,000 | 7,491,000 | 14,139,444 | Aug 26, 2016, 04:30 PM |
| ALDX | | Aldeyra Therapeutics, Inc. | Perceptive Advisors LLC | 10% Owner | May 26, 2016 | Buy | $5.00 | 700,000 | 3,500,000 | 1,940,458 | May 26, 2016, 02:50 PM |
| ACRX | | ACELRX PHARMACEUTICALS INC | Perceptive Advisors LLC | 10% Owner | Nov 17, 2015 | Sale | $5.36 | 133,900 | 717,409 | 6,038,060 | Nov 19, 2015, 04:15 PM |
| ACRX | | ACELRX PHARMACEUTICALS INC | Perceptive Advisors LLC | 10% Owner | Nov 18, 2015 | Sale | $5.35 | 42,300 | 226,132 | 5,995,760 | Nov 19, 2015, 04:15 PM |
| ACRX | | ACELRX PHARMACEUTICALS INC | Perceptive Advisors LLC | 10% Owner | Nov 06, 2015 | Sale | $4.47 | 17,100 | 76,365 | 6,171,960 | Nov 09, 2015, 04:30 PM |
| ACRX | | ACELRX PHARMACEUTICALS INC | Perceptive Advisors LLC | 10% Owner | Nov 05, 2015 | Sale | $4.62 | 75,000 | 346,260 | 6,189,060 | Nov 09, 2015, 04:30 PM |
| ALDX | | Aldeyra Therapeutics, Inc. | Perceptive Advisors LLC | 10% Owner | Oct 28, 2015 | Buy | $6.50 | 45,100 | 293,150 | 1,240,458 | Nov 05, 2015, 04:16 PM |
| ALDX | | Aldeyra Therapeutics, Inc. | Perceptive Advisors LLC | 10% Owner | Oct 26, 2015 | Buy | $6.46 | 50,000 | 323,150 | 1,195,358 | Oct 28, 2015, 02:30 PM |
| ALDX | | Aldeyra Therapeutics, Inc. | Perceptive Advisors LLC | 10% Owner | Oct 22, 2015 | Buy | $6.47 | 18,020 | 116,661 | 1,145,358 | Oct 26, 2015, 04:05 PM |
| ALDX | | Aldeyra Therapeutics, Inc. | Perceptive Advisors LLC | 10% Owner | Oct 20, 2015 | Buy | $6.39 | 37,145 | 237,193 | 1,127,338 | Oct 22, 2015, 11:50 AM |
| FOLD | | AMICUS THERAPEUTICS INC | Perceptive Advisors LLC | 10% Owner | Oct 07, 2015 | Buy | $6.27 | 50,000 | 313,500 | 15,239,444 | Oct 08, 2015, 09:18 AM |
| FOLD | | AMICUS THERAPEUTICS INC | Perceptive Advisors LLC | 10% Owner | Oct 05, 2015 | Buy | $6.81 | 500,000 | 3,402,500 | 14,939,444 | Oct 07, 2015, 10:27 AM |
| FOLD | | AMICUS THERAPEUTICS INC | Perceptive Advisors LLC | 10% Owner | Oct 06, 2015 | Buy | $6.52 | 250,000 | 1,629,000 | 15,189,444 | Oct 07, 2015, 10:27 AM |
| ACRX | | ACELRX PHARMACEUTICALS INC | Perceptive Advisors LLC | 10% Owner | Sep 09, 2015 | Sale | $4.18 | 310,000 | 1,294,777 | 6,264,060 | Sep 11, 2015, 04:01 PM |
| FOLD | | AMICUS THERAPEUTICS INC | Perceptive Advisors LLC | 10% Owner | Nov 19, 2014 | Buy | $6.50 | 2,100,000 | 13,650,000 | 14,439,444 | Nov 19, 2014, 02:55 PM |
| FOLD | | AMICUS THERAPEUTICS INC | Perceptive Advisors LLC | 10% Owner | Jun 30, 2014 | Buy | $3.50 | 4,000,000 | 14,000,000 | 12,339,444 | Jul 01, 2014, 10:56 AM |
| ACRX | | ACELRX PHARMACEUTICALS INC | Perceptive Advisors LLC | 10% Owner | Nov 06, 2013 | Buy | $6.52 | 100,000 | 651,660 | 6,474,060 | Nov 12, 2013, 07:16 AM |
| ACRX | | ACELRX PHARMACEUTICALS INC | Perceptive Advisors LLC | 10% Owner | Nov 07, 2013 | Buy | $6.50 | 100,000 | 649,810 | 6,574,060 | Nov 12, 2013, 07:16 AM |
| ACRX | | ACELRX PHARMACEUTICALS INC | Perceptive Advisors LLC | 10% Owner | Nov 04, 2013 | Buy | $6.87 | 155,000 | 1,064,292 | 6,374,060 | Nov 06, 2013, 11:47 AM |
| ACRX | | ACELRX PHARMACEUTICALS INC | Perceptive Advisors LLC | 10% Owner | Oct 31, 2013 | Buy | $6.69 | 200,000 | 1,338,640 | 6,058,400 | Nov 04, 2013, 01:07 PM |
| ACRX | | ACELRX PHARMACEUTICALS INC | Perceptive Advisors LLC | 10% Owner | Nov 01, 2013 | Buy | $7.17 | 160,660 | 1,151,900 | 6,219,060 | Nov 04, 2013, 01:07 PM |
| ACRX | | ACELRX PHARMACEUTICALS INC | Perceptive Advisors LLC | 10% Owner | Jul 23, 2013 | Buy | $11.65 | 850,000 | 9,902,500 | 5,858,400 | Jul 24, 2013, 02:26 PM |
