| SPY | STATE STR SPDR S&P 500 ETF T (Put) | 20.69% | 6,000,000 | $4,480,620,000 | 6,000,000 | New | $746.77 | 13F |
| RVMD | REVOLUTION MEDICINES INC | 11.72% | 13,550,796 | $2,537,793,075 | -54,000 | -0.4% | $187.28 | 13F |
| EA | ELECTRONIC ARTS INC | 7.50% | 7,919,500 | $1,623,814,280 | 449,500 | 6.02% | $205.04 | 13F |
| BBIO | BRIDGEBIO PHARMA INC | 3.69% | 10,743,063 | $800,143,332 | 1,377,600 | 14.71% | $74.48 | 13F |
| PTGX | PROTAGONIST THERAPEUTICS INC | 3.59% | 6,348,906 | $778,248,897 | | No Change | $122.58 | 13F |
| EXEL | EXELIXIS, INC. | 3.31% | 13,989,010 | $716,796,872 | 521,000 | 3.87% | | 13D |
| LQDA | LIQUIDIA CORPORATION | 3.08% | 8,365,038 | $666,944,480 | -291,000 | -3.36% | $79.73 | 13F |
| AMZN | AMAZON COM INC | 2.90% | 2,632,994 | $627,547,790 | -1,585,400 | -37.58% | $238.34 | 13F |
| LNTH | LANTHEUS HLDGS INC | 2.86% | 5,583,479 | $619,431,160 | | No Change | $110.94 | 13F |
| NTRA | NATERA INC | 2.78% | 2,218,366 | $602,175,451 | -989,000 | -30.84% | $271.45 | 13F |
| UNH | UNITEDHEALTH GROUP INC | 2.44% | 1,270,532 | $528,071,215 | -551,174 | -30.26% | $415.63 | 13F |
| TMO | THERMO FISHER SCIENTIFIC INC | 2.43% | 1,049,185 | $526,019,392 | 167,700 | 19.02% | $501.36 | 13F |
| ROIV | ROIVANT SCIENCES LTD | 2.34% | 14,309,000 | $506,395,510 | 4,634,000 | 47.9% | $35.39 | 13F |
| AON | AON PLC | 2.12% | 1,382,562 | $458,581,990 | -1,130,076 | -44.98% | $331.69 | 13F |
| BSX | BOSTON SCIENTIFIC CORP | 2.07% | 10,521,184 | $449,044,133 | 3,050,500 | 40.83% | $42.68 | 13F |
| AVGO | BROADCOM INC | 2.01% | 1,151,800 | $435,092,450 | -627,700 | -35.27% | $377.75 | 13F |
| MSFT | MICROSOFT CORP | 1.92% | 1,112,863 | $415,120,156 | -1,231,916 | -52.54% | $373.02 | 13F |
| TNGX | TANGO THERAPEUTICS INC | 1.77% | 12,277,000 | $383,779,020 | 3,179,589 | 34.95% | $31.26 | 13F |
| KKR | KKR & CO INC | 1.75% | 4,118,300 | $377,977,574 | -553,500 | -11.85% | $91.78 | 13F |
| SNPS | SYNOPSYS INC | 1.71% | 829,600 | $370,059,672 | -383,700 | -31.62% | $446.07 | 13F |
| BEAM | BEAM THERAPEUTICS INC | 1.62% | 10,236,396 | $351,313,111 | 101,700 | 1% | $34.32 | 13F |
| CRNX | CRINETICS PHARMACEUTICALS IN | 1.55% | 8,989,098 | $336,372,047 | 651,000 | 7.81% | $37.42 | 13F |
| GRAL | GRAIL INC | 1.31% | 4,161,584 | $284,111,340 | 907,900 | 27.9% | $68.27 | 13F |
| WAB | WABTEC | 1.11% | 894,503 | $241,158,009 | -714,900 | -44.42% | $269.6 | 13F |
| IMVT | IMMUNOVANT INC | 1.03% | 5,805,000 | $223,666,650 | 4,259,000 | 275.49% | $38.53 | 13F |
| AGIO | AGIOS PHARMACEUTICALS INC | 1.01% | 5,917,400 | $219,594,714 | 233,400 | 4.11% | $37.11 | 13F |
| TWST | TWIST BIOSCIENCE CORP | 1.01% | 2,136,400 | $219,792,832 | 708,750 | 49.64% | $102.88 | 13F |
| ARMK | ARAMARK | 0.95% | 3,625,731 | $206,304,094 | -2,509,700 | -40.91% | $56.9 | 13F |
| BIDU | BAIDU INC | 0.64% | 1,203,785 | $137,580,588 | 760,000 | 171.25% | $114.29 | 13F |
| ACHC | ACADIA HEALTHCARE COMPANY IN | 0.58% | 4,220,800 | $124,640,224 | 2,484,000 | 143.02% | $29.53 | 13F |
| NVO | NOVO-NORDISK A S | 0.58% | 2,619,000 | $125,554,860 | 1,837,000 | 234.91% | $47.94 | 13F |
| BTSG | BRIGHTSPRING HEALTH SVCS INC | 0.56% | 1,732,800 | $120,845,472 | 115,800 | 7.16% | $69.74 | 13F |
| AZN | ASTRAZENECA PLC | 0.50% | 574,000 | $108,841,880 | 347,501 | 153.42% | $189.62 | 13F |
| JNJ | JOHNSON & JOHNSON | 0.48% | 408,000 | $103,619,760 | 260,000 | 175.68% | $253.97 | 13F |
| SOXX | ISHARES TR (Put) | 0.38% | 130,000 | $83,298,800 | 130,000 | New | $640.76 | 13F |
| STRK | STRATEGY INC (PRN) | 0.35% | 87,858,000 | $75,366,666 | 48,358,000 | 122.43% | $0.86 | 13F |
| PBLS | PARABILIS MEDICINES INC | 0.30% | 2,368,200 | $64,817,634 | 2,368,200 | New | $27.37 | 13F |
| NVS | NOVARTIS AG | 0.26% | 363,000 | $56,889,360 | 363,000 | New | $156.72 | 13F |
| GH | GUARDANT HEALTH INC | 0.22% | 322,200 | $48,339,666 | 314,200 | 3927.5% | $150.03 | 13F |
| VNET | VNET GROUP INC (PRN) | 0.22% | 45,000,000 | $46,808,834 | | No Change | $1.04 | 13F |
| AVTX | AVALO THERAPEUTICS INC | 0.21% | 2,498,000 | $46,163,040 | 1,582,000 | 172.71% | $18.48 | 13F |
| JOYY | JOYY INC | 0.21% | 699,200 | $46,140,208 | 121,000 | 20.93% | $65.99 | 13F |
| ASMB | ASSEMBLY BIOSCIENCES INC | 0.20% | 1,604,590 | $44,094,133 | 377,000 | 30.71% | $27.48 | 13F |
| ENTA | ENANTA PHARMACEUTICALS INC | 0.16% | 2,418,202 | $35,257,385 | -453,660 | -15.8% | $14.58 | 13F |
| MAZE | MAZE THERAPEUTICS INC | 0.15% | 1,107,814 | $33,057,170 | 734,814 | 197% | $29.84 | 13F |
| CGON | CG ONCOLOGY INC (Call) | 0.13% | 400,000 | $28,420,000 | 400,000 | New | $71.05 | 13F |
| MRK | MERCK & CO INC | 0.12% | 199,000 | $25,571,500 | -162,000 | -44.88% | $128.5 | 13F |
| WRBY | WARBY PARKER INC | 0.12% | 828,000 | $25,121,520 | 828,000 | New | $30.34 | 13F |
| KLRA | KAILERA THERAPEUTICS INC | 0.11% | 1,100,000 | $24,233,000 | 1,100,000 | New | $22.03 | 13F |
| PCSC | PERCEPTIVE CAP SOLUTIONS COR | 0.11% | 2,250,000 | $24,480,000 | | No Change | $10.88 | 13F |
| ABVX | ABIVAX SA | 0.08% | 122,000 | $16,257,720 | 120,000 | 6000% | $133.26 | 13F |
| RIO | RIO TINTO PLC | 0.08% | 183,475 | $17,417,282 | 129,675 | 241.03% | $94.93 | 13F |
| AXTA | AXALTA COATING SYS LTD | 0.08% | 478,000 | $16,357,160 | 478,000 | New | $34.22 | 13F |
| BIIB | BIOGEN INC | 0.07% | 71,000 | $15,340,260 | 71,000 | New | $216.06 | 13F |
| STRK | STRATEGY INC (PRN) | 0.07% | 15,000,000 | $14,189,967 | 15,000,000 | New | $0.95 | 13F |
| MOBI | MOBIA MED INC | 0.07% | 1,128,557 | $15,122,664 | 1,128,557 | New | $13.4 | 13F |
| NTES | NETEASE COM INC | 0.07% | 123,500 | $15,825,290 | -167,719 | -57.59% | $128.14 | 13F |
| TSHA | TAYSHA GENE THERAPIES INC | 0.07% | 2,250,000 | $15,322,500 | 2,250,000 | New | $6.81 | 13F |
| VNET | VNET GROUP INC | 0.07% | 1,992,000 | $16,015,680 | 1,368,653 | 219.57% | $8.04 | 13F |
| ALMR | ALAMAR BIOSCIENCES INC | 0.06% | 462,900 | $12,539,961 | 462,900 | New | $27.09 | 13F |
| NERV | MINERVA NEUROSCIENCES INC | 0.06% | 2,365,000 | $13,125,750 | | No Change | $5.55 | 13F |
| ALVO | ALVOTECH | 0.05% | 2,859,675 | $10,552,201 | 2,660,000 | 1332.16% | $3.69 | 13F |
| BBNX | BETA BIONICS INC | 0.04% | 595,000 | $9,323,650 | -3,012,920 | -83.51% | $15.67 | 13F |
| SMG | SCOTTS MIRACLE-GRO CO | 0.03% | 88,000 | $5,993,680 | 88,000 | New | $68.11 | 13F |
| WAY | WAYSTAR HLDG CORP | 0.03% | 264,900 | $5,438,397 | 264,900 | New | $20.53 | 13F |
| IFRX | INFLARX NV | 0.03% | 3,325,000 | $7,448,000 | 3,325,000 | New | $2.24 | 13F |
| BC | BRUNSWICK CORP | 0.02% | 61,000 | $5,138,640 | 61,000 | New | $84.24 | 13F |
| CMC | COMMERCIAL METALS CO | 0.02% | 67,000 | $4,204,250 | 67,000 | New | $62.75 | 13F |
| GNTX | GENTEX CORP | 0.02% | 199,000 | $5,028,730 | 199,000 | New | $25.27 | 13F |
| IDXX | IDEXX LABS INC | 0.02% | 9,000 | $4,737,960 | 9,000 | New | $526.44 | 13F |
| PRME | PRIME MEDICINE INC | 0.02% | 1,240,843 | $4,578,711 | | No Change | $3.69 | 13F |
| JATT | JATT II ACQUISITION CORP | 0.02% | 300,000 | $3,408,000 | 300,000 | New | $11.36 | 13F |
| STRK | STRATEGY INC (PRN) | 0.01% | 2,632,000 | $2,318,158 | 2,632,000 | New | $0.88 | 13F |
| SGMT | SAGIMET BIOSCIENCES INC | 0.01% | 415,000 | $3,207,950 | 415,000 | New | $7.73 | 13F |
| SMC | SUMMIT MIDSTREAM CORPORATION | 0.00765% | 58,214 | $1,657,935 | | No Change | $28.48 | 13F |
| TEVA | TEVA PHARMACEUTICAL INDS LTD | 0.00626% | 40,000 | $1,355,200 | -314,000 | -88.7% | $33.88 | 13F |
| RVMDW | REVOLUTION MEDICINES INC | 0.00521% | 120,085 | $1,128,799 | | No Change | $9.4 | 13F |
| COGT | COGENT BIOSCIENCES INC | 0.00304% | 17,000 | $657,900 | | No Change | $38.7 | 13F |
| ANNAW | ALEANNA INC | 0.00137% | 990,000 | $297,000 | | No Change | $0.3 | 13F |
| ANNA | ALEANNA INC | 0.00105% | 78,400 | $227,360 | | No Change | $2.9 | 13F |
| WELL | WELLTOWER INC | 0.00105% | 1,000 | $226,970 | -199,000 | -99.5% | $226.97 | 13F |
| SLDPW | SOLID POWER INC | 0.00019% | 405,316 | $41,423 | | No Change | $0.1 | 13F |
| BGLWW | BLUE GOLD LTD | 0.00014% | 255,800 | $30,696 | -44,200 | -14.73% | $0.12 | 13F |
| PACB | PACIFIC BIOSCIENCES CALIF IN | 0.00011% | 14,200 | $23,856 | -120,800 | -89.48% | $1.68 | 13F |
| GERN | GERON CORP | 0.00009% | 14,400 | $18,432 | -28,600 | -66.51% | $1.28 | 13F |
| CGC | CANOPY GROWTH CORPORATION | 0.00008% | 18,000 | $17,100 | -12,000 | -40% | $0.95 | 13F |
| NVNIW | NVNI GROUP LIMITED | 0.00008% | 375,000 | $17,550 | | No Change | $0.05 | 13F |
| RANI | RANI THERAPEUTICS HLDGS INC | 0.00007% | 20,700 | $15,740 | -57,300 | -73.46% | $0.76 | 13F |
| BYND | BEYOND MEAT INC | 0.00007% | 19,000 | $14,250 | | No Change | $0.75 | 13F |
| AIR | AAR CORP | | | | -46,000 | Exited | | 13F |
| ADPT | ADAPTIVE BIOTECHNOLOGIES COR | | | | -11,000 | Exited | | 13F |
| AFRM | AFFIRM HLDGS INC | | | | -108,000 | Exited | | 13F |
| GOOG | ALPHABET INC | | | | -996,231 | Exited | | 13F |
| ALT | ALTIMMUNE INC | | | | -27,600 | Exited | | 13F |
| ALMS | ALUMIS INC | | | | -11,000 | Exited | | 13F |
| COR | CENCORA INC | | | | -1,000 | Exited | | 13F |
| FOLD | AMICUS THERAPEUTIC | | | | -16,000 | Exited | | 13F |
| AMKR | AMKOR TECHNOLOGY INC | | | | -104,000 | Exited | | 13F |
| APLS | APELLIS PHARMACEUTICALS INC | | | | -6,000 | Exited | | 13F |
| ARDX | ARDELYX INC | | | | -23,000 | Exited | | 13F |
| ARQT | ARCUTIS BIOTHERAPEUTICS INC | | | | -26,000 | Exited | | 13F |
| ARWR | ARROWHEAD PHARMACEUTICALS IN | | | | -15,800 | Exited | | 13F |
| RNA | ATRIUM THERAPEUTICS INC | | | | -349,360 | Exited | | 13F |
| AXSM | AXSOME THERAPEUTICS INC. | | | | -4,000 | Exited | | 13F |
| ONC | BEONE MEDICINES LTD | | | | -1,100 | Exited | | 13F |
| BLTE | BELITE BIO INC | | | | -1,300 | Exited | | 13F |
| BCRX | BIOCRYST PHARMACEUTICALS INC | | | | -24,000 | Exited | | 13F |
| BITW | BITWISE 10 CRYPTO INDEX ETF | | | | -603,000 | Exited | | 13F |
| CECO | CECO ENVIRONMENTAL CORP | | | | -234,000 | Exited | | 13F |
| CCCC | C4 THERAPEUTICS INC | | | | -28,000 | Exited | | 13F |
| CAPR | CAPRICOR THERAPEUTICS INC | | | | -41,000 | Exited | | 13F |
| TVRD | TVARDI THERAPEUTICS INC | | | | -21,438 | Exited | | 13F |
| CAH | CARDINAL HEALTH INC | | | | -368,000 | Exited | | 13F |
| CELC | CELCUITY INC | | | | -4,000 | Exited | | 13F |
| CNTA | CENTESSA PHARMACEUTICALS PLC | | | | -4,809,000 | Exited | | 13F |
| CGON | CG ONCOLOGY INC | | | | -674,000 | Exited | | 13F |
| CGON | CG ONCOLOGY INC (Call) | | | | -200,000 | Exited | | 13F |
| C | CITIGROUP INC | | | | -47,000 | Exited | | 13F |
| CMI | CUMMINS INC | | | | -9,000 | Exited | | 13F |
| DNTH | DIANTHUS THERAPEUTICS INC | | | | -836,000 | Exited | | 13F |
| DIS | DISNEY WALT CO | | | | -2,401,591 | Exited | | 13F |
| DYN | DYNE THERAPEUTICS INC | | | | -10,000 | Exited | | 13F |
| EHC | ENCOMPASS HEALTH CORP | | | | -3,000 | Exited | | 13F |
| ENTG | ENTEGRIS INC | | | | -45,500 | Exited | | 13F |
| ERAS | ERASCA INC | | | | -18,000 | Exited | | 13F |
| EVH | EVOLENT HEALTH INC | | | | -14,000 | Exited | | 13F |
| FI | FISERV INC | | | | -86,000 | Exited | | 13F |
| FORM | FORMFACTOR INC | | | | -56,500 | Exited | | 13F |
| GDS | GDS HLDGS LTD | | | | -292,000 | Exited | | 13F |
| GEHC | GE HEALTHCARE TECHNOLOGIES I | | | | -3,000 | Exited | | 13F |
| GTX | GARRETT MOTION INC | | | | -275,000 | Exited | | 13F |
| GKOS | GLAUKOS CORP | | | | -2,600 | Exited | | 13F |
| GMED | GLOBUS MED INC | | | | -4,000 | Exited | | 13F |
| GRFS | GRIFOLS S A | | | | -28,000 | Exited | | 13F |
| HQY | HEALTHEQUITY INC | | | | -2,800 | Exited | | 13F |
| HR | HEALTHCARE RLTY TR | | | | -12,000 | Exited | | 13F |
| HIMS | HIMS & HERS HEALTH INC | | | | -10,000 | Exited | | 13F |
| H | HYATT HOTELS CORP | | | | -36,000 | Exited | | 13F |
| PBP | INVESCO EXCHANGE TRADED FD T (Put) | | | | -3,600,000 | Exited | | 13F |
| IONS | IONIS PHARMACEUTICALS INC | | | | -4,800 | Exited | | 13F |
| IOVA | IOVANCE BIOTHERAPEUTICS INC | | | | -26,000 | Exited | | 13F |
| IRWD | IRONWOOD PHARMACEUTICALS INC | | | | -13,000 | Exited | | 13F |
| KRYS | KRYSTAL BIOTECH INC | | | | -1,000 | Exited | | 13F |
| LFUS | LITTELFUSE INC | | | | -15,000 | Exited | | 13F |
| MDGL | MADRIGAL PHARMACEUTICALS INC | | | | -3,319 | Exited | | 13F |
| MTZ | MASTEC INC | | | | -17,000 | Exited | | 13F |
| MA | MASTERCARD INCORPORATED | | | | -435,071 | Exited | | 13F |
| MCK | MCKESSON CORP | | | | -234,300 | Exited | | 13F |
| MMSI | MERIT MED SYS INC | | | | -3,000 | Exited | | 13F |
| MIRM | MIRUM PHARMACEUTICALS INC | | | | -3,000 | Exited | | 13F |
| MOH | MOLINA HEALTHCARE INC | | | | -35,000 | Exited | | 13F |
| NKTR | NEKTAR THERAPEUTICS | | | | -4,000 | Exited | | 13F |
| NEO | NEOGENOMICS INC | | | | -19,000 | Exited | | 13F |
| NVAX | NOVAVAX INC | | | | -22,000 | Exited | | 13F |
| NUVL | NUVALENT INC | | | | -3,000 | Exited | | 13F |
| NUVB | NUVATION BIO INC | | | | -29,000 | Exited | | 13F |
| OCUL | OCULAR THERAPEUTIX INC | | | | -18,000 | Exited | | 13F |
| IRD | OPUS GENETICS INC | | | | -1,000,000 | Exited | | 13F |
| OMER | OMEROS CORP | | | | -23,000 | Exited | | 13F |
| OSCR | OSCAR HEALTH INC | | | | -11,000 | Exited | | 13F |
| PIPR | PIPER SANDLER COMPANIES | | | | -66,000 | Exited | | 13F |
| PGEN | PRECIGEN INC | | | | -50,000 | Exited | | 13F |
| ROL | ROLLINS INC | | | | -93,000 | Exited | | 13F |
| PGNY | PROGYNY INC | | | | -18,000 | Exited | | 13F |
| SPGI | S&P GLOBAL INC | | | | -12,000 | Exited | | 13F |
| SPY | STATE STR SPDR S&P 500 ETF T (Put) | | | | -2,300,000 | Exited | | 13F |
| SBRA | SABRA HEALTH CARE REIT INC | | | | -14,000 | Exited | | 13F |
| SRRK | SCHOLAR ROCK HLDG CORP | | | | -7,000 | Exited | | 13F |
| SDGR | SCHRODINGER INC | | | | -17,000 | Exited | | 13F |
| SCHW | SCHWAB CHARLES CORP | | | | -3,955,657 | Exited | | 13F |
| SLS | SELLAS LIFE SCIENCES GROUP I | | | | -40,000 | Exited | | 13F |
| WGS | GENEDX HOLDINGS CORP | | | | -5,000 | Exited | | 13F |
| NOW | SERVICENOW INC | | | | -41,000 | Exited | | 13F |
| STOK | STOKE THERAPEUTICS INC | | | | -9,000 | Exited | | 13F |
| SUPN | SUPERNUS PHARMACEUTICALS | | | | -4,000 | Exited | | 13F |
| SNDX | SYNDAX PHARMACEUTICALS INC | | | | -10,000 | Exited | | 13F |
| TENB | TENABLE HLDGS INC | | | | -265,000 | Exited | | 13F |
| THC | TENET HEALTHCARE CORP | | | | -452,153 | Exited | | 13F |
| TERN | TERNS PHARMACEUTICALS INC | | | | -7,000 | Exited | | 13F |
| TKR | TIMKEN CO | | | | -51,000 | Exited | | 13F |
| TVTX | TRAVERE THERAPEUTICS INC | | | | -12,000 | Exited | | 13F |
| TYRA | TYRA BIOSCIENCES INC | | | | -3,580,818 | Exited | | 13F |
| PCVX | VAXCYTE INC | | | | -1,261,000 | Exited | | 13F |
| VCYT | VERACYTE INC | | | | -7,000 | Exited | | 13F |
| VRT | VERTIV HOLDINGS CO | | | | -19,000 | Exited | | 13F |
| VIR | VIR BIOTECHNOLOGY INC | | | | -22,000 | Exited | | 13F |
| V | VISA INC | | | | -840,710 | Exited | | 13F |
| WAL | WESTERN ALLIANCE BANCORP | | | | -73,000 | Exited | | 13F |
| ALKS | ALKERMES PLC | | | | -20,800 | Exited | | 13F |
| GFS | GLOBALFOUNDRIES INC | | | | -105,000 | Exited | | 13F |
| INTR | INTER & CO INC | | | | -614,500 | Exited | | 13F |
| LIVN | LIVANOVA PLC | | | | -6,000 | Exited | | 13F |
| RPRX | ROYALTY PHARMA PLC | | | | -493,000 | Exited | | 13F |
| URGN | UROGEN PHARMA LTD | | | | -11,000 | Exited | | 13F |
| QURE | UNIQURE NV | | | | -14,000 | Exited | | 13F |
| FLEX | FLEXTRONICS INTL LTD | | | | -78,000 | Exited | | 13F |
