| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Pamela J. Cramer | Chief Human Resources Officer | Feb 01, 2026 | Tax Payment (Shares) | $108.99 | 4,731 | 515,632 | 29,376 | Feb 03, 2026, 04:30 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Pamela J. Cramer | Chief Human Resources Officer | Feb 01, 2026 | Option/RSU Exercise | - | 13,293 | - | 34,107 | Feb 03, 2026, 04:30 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Pamela J. Cramer | Chief Human Resources Officer | Dec 11, 2025 | Sale | $111.00 | 3,350 | 371,850 | 20,814 | Dec 15, 2025, 04:30 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Pamela J. Cramer | Chief Human Resources Officer | Dec 11, 2025 | Option/RSU Exercise | $27.35 | 3,350 | 91,623 | 24,164 | Dec 15, 2025, 04:30 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Pamela J. Cramer | Chief Human Resources Officer | Nov 20, 2025 | Option/RSU Exercise | $27.35 | 3,350 | 91,623 | 24,164 | Nov 24, 2025, 04:15 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Pamela J. Cramer | Chief Human Resources Officer | Nov 20, 2025 | Sale | $105.00 | 3,350 | 351,750 | 20,814 | Nov 24, 2025, 04:15 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Pamela J. Cramer | Chief Human Resources Officer | Nov 07, 2025 | Sale | $98.82 | 19,351 | 1,912,326 | 20,814 | Nov 12, 2025, 04:30 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Pamela J. Cramer | Chief Human Resources Officer | Nov 10, 2025 | Option/RSU Exercise | $6.80 | 3,515 | 23,902 | 24,329 | Nov 12, 2025, 04:30 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Pamela J. Cramer | Chief Human Resources Officer | Nov 10, 2025 | Sale | $100.00 | 3,515 | 351,500 | 20,814 | Nov 12, 2025, 04:30 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Pamela J. Cramer | Chief Human Resources Officer | Nov 07, 2025 | Option/RSU Exercise | $12.36 | 19,351 | 239,184 | 40,165 | Nov 12, 2025, 04:30 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Pamela J. Cramer | Chief Human Resources Officer | Jul 26, 2025 | Option/RSU Exercise | - | 3,125 | - | 22,334 | Jul 29, 2025, 06:56 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Pamela J. Cramer | Chief Human Resources Officer | Jul 29, 2025 | Sale | $85.93 | 1,520 | 130,614 | 20,814 | Jul 29, 2025, 06:56 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Pamela J. Cramer | Chief Human Resources Officer | Jul 09, 2025 | Option/RSU Exercise | $13.43 | 15,572 | 209,153 | 34,781 | Jul 11, 2025, 04:30 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Pamela J. Cramer | Chief Human Resources Officer | Jul 09, 2025 | Sale | $77.13 | 15,572 | 1,201,062 | 30,556 | Jul 11, 2025, 04:30 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Pamela J. Cramer | Chief Human Resources Officer | Jun 06, 2025 | Option/RSU Exercise | $6.80 | 7,031 | 47,811 | 26,240 | Jun 10, 2025, 04:45 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Pamela J. Cramer | Chief Human Resources Officer | Jun 06, 2025 | Sale | $68.05 | 7,031 | 478,435 | 19,209 | Jun 10, 2025, 04:45 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Pamela J. Cramer | Chief Human Resources Officer | Apr 29, 2025 | Option/RSU Exercise | $6.80 | 7,031 | 47,811 | 26,240 | May 01, 2025, 04:53 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Pamela J. Cramer | Chief Human Resources Officer | Apr 29, 2025 | Sale | $65.09 | 7,031 | 457,663 | 19,209 | May 01, 2025, 04:53 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Pamela J. Cramer | Chief Human Resources Officer | Apr 08, 2025 | Sale | $60.14 | 20,760 | 1,248,490 | 33,539 | Apr 10, 2025, 05:17 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Pamela J. Cramer | Chief Human Resources Officer | Apr 08, 2025 | Option/RSU Exercise | $13.43 | 20,760 | 278,853 | 39,969 | Apr 10, 2025, 05:17 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Pamela J. Cramer | Chief Human Resources Officer | Feb 16, 2025 | Option/RSU Exercise | - | 3,300 | - | 20,191 | Feb 19, 2025, 09:43 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Pamela J. Cramer | Chief Human Resources Officer | Feb 19, 2025 | Sale | $57.22 | 982 | 56,190 | 19,209 | Feb 19, 2025, 09:43 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Pamela J. Cramer | Chief Human Resources Officer | Feb 09, 2025 | Option/RSU Exercise | - | 2,344 | - | 17,592 | Feb 11, 2025, 09:45 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Pamela J. Cramer | Chief Human Resources Officer | Feb 11, 2025 | Sale | $57.51 | 701 | 40,315 | 16,894 | Feb 11, 2025, 09:45 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Pamela J. Cramer | Chief Human Resources Officer | Feb 04, 2025 | Sale | $59.43 | 902 | 53,606 | 15,248 | Feb 04, 2025, 09:22 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Pamela J. Cramer | Chief Human Resources Officer | Feb 01, 2025 | Option/RSU Exercise | - | 2,650 | - | 16,150 | Feb 04, 2025, 09:22 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Pamela J. Cramer | Chief Human Resources Officer | Nov 06, 2024 | Option/RSU Exercise | $19.02 | 4,687 | 89,147 | 18,187 | Nov 08, 2024, 04:15 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Pamela J. Cramer | Chief Human Resources Officer | Nov 06, 2024 | Sale | $60.00 | 4,687 | 281,220 | 13,500 | Nov 08, 2024, 04:15 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Pamela J. Cramer | Chief Human Resources Officer | Nov 07, 2024 | Option/RSU Exercise | $19.02 | 4,688 | 89,166 | 18,188 | Nov 08, 2024, 04:15 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Pamela J. Cramer | Chief Human Resources Officer | Nov 07, 2024 | Sale | $65.00 | 4,688 | 304,720 | 13,500 | Nov 08, 2024, 04:15 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Pamela J. Cramer | Chief Human Resources Officer | Sep 09, 2024 | Option/RSU Exercise | $19.02 | 4,099 | 77,963 | 17,599 | Sep 11, 2024, 04:32 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Pamela J. Cramer | Chief Human Resources Officer | Sep 09, 2024 | Sale | $50.03 | 4,099 | 205,062 | 13,500 | Sep 11, 2024, 04:32 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Pamela J. Cramer | Chief Human Resources Officer | Aug 26, 2024 | Option/RSU Exercise | $19.02 | 3,200 | 60,864 | 16,700 | Aug 28, 2024, 04:31 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Pamela J. Cramer | Chief Human Resources Officer | Aug 26, 2024 | Sale | $50.01 | 3,200 | 160,018 | 13,500 | Aug 28, 2024, 04:31 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Pamela J. Cramer | Chief Human Resources Officer | Aug 09, 2024 | Sale | $45.15 | 49,006 | 2,212,498 | 15,604 | Aug 13, 2024, 04:45 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Pamela J. Cramer | Chief Human Resources Officer | Aug 09, 2024 | Option/RSU Exercise | $19.02 | 30,771 | 585,264 | 62,506 | Aug 13, 2024, 04:45 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Pamela J. Cramer | Chief Human Resources Officer | Jul 26, 2024 | Option/RSU Exercise | - | 3,125 | - | 33,130 | Jul 30, 2024, 05:09 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Pamela J. Cramer | Chief Human Resources Officer | Jul 29, 2024 | Sale | $49.06 | 1,395 | 68,439 | 31,735 | Jul 30, 2024, 05:09 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Pamela J. Cramer | Chief Human Resources Officer | Mar 19, 2024 | Sale | $39.22 | 15,515 | 608,498 | 30,005 | Mar 19, 2024, 08:50 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Pamela J. Cramer | Chief Human Resources Officer | Feb 09, 2024 | Option/RSU Exercise | - | 2,344 | - | 12,466 | Feb 13, 2024, 08:45 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Pamela J. Cramer | Chief Human Resources Officer | Feb 12, 2024 | Sale | $51.38 | 696 | 35,760 | 11,770 | Feb 13, 2024, 08:45 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Pamela J. Cramer | Chief Human Resources Officer | Feb 01, 2024 | Option/RSU Exercise | - | 2,650 | - | 11,068 | Feb 05, 2024, 06:53 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Pamela J. Cramer | Chief Human Resources Officer | Feb 01, 2024 | Sale | $45.06 | 946 | 42,627 | 10,122 | Feb 05, 2024, 06:53 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Pamela J. Cramer | Chief Human Resources Officer | Jul 26, 2023 | Option/RSU Exercise | - | 3,125 | - | 9,348 | Jul 28, 2023, 09:01 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Pamela J. Cramer | Chief Human Resources Officer | Jul 26, 2023 | Sale | $17.64 | 930 | 16,405 | 8,418 | Jul 28, 2023, 09:01 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Pamela J. Cramer | Chief Human Resources Officer | Feb 09, 2023 | Sale | $27.51 | 843 | 23,191 | 6,142 | Feb 14, 2023, 07:30 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Pamela J. Cramer | Chief Human Resources Officer | Feb 09, 2023 | Option/RSU Exercise | - | 2,344 | - | 6,985 | Feb 13, 2023, 05:02 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Pamela J. Cramer | Chief Human Resources Officer | Feb 09, 2023 | Sale | $27.66 | 834 | 23,068 | 6,151 | Feb 13, 2023, 05:02 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Pamela J. Cramer | Chief Human Resources Officer | Aug 19, 2022 | Option/RSU Exercise | $19.02 | 13,493 | 256,637 | 15,717 | Aug 23, 2022, 04:30 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Pamela J. Cramer | Chief Human Resources Officer | Aug 19, 2022 | Sale | $24.83 | 13,493 | 335,031 | 2,224 | Aug 23, 2022, 04:30 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Pamela J. Cramer | Chief Human Resources Officer | Jul 27, 2022 | Sale | $11.68 | 901 | 10,524 | 2,224 | Jul 28, 2022, 04:31 PM |
| RYTM | | RHYTHM PHARMACEUTICALS, INC. | Pamela J. Cramer | Chief Human Resources Officer | Jul 26, 2022 | Option/RSU Exercise | - | 3,125 | - | 3,125 | Jul 28, 2022, 04:31 PM |