| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | EVP, Chief Reg. & Quality Off. | Feb 24, 2026 | Tax Payment (Shares) | $485.11 | 1,627 | 789,274 | 47,023 | Feb 26, 2026, 06:55 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | EVP, Chief Reg. & Quality Off. | Feb 25, 2026 | Sale | $486.35 | 260 | 126,451 | 46,763 | Feb 26, 2026, 06:55 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | EVP, Chief Reg. & Quality Off. | Feb 17, 2026 | Tax Payment (Shares) | $483.75 | 2,294 | 1,109,723 | 49,627 | Feb 19, 2026, 04:28 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | EVP, Chief Reg. & Quality Off. | Feb 17, 2026 | Sale | $489.46 | 609 | 298,081 | 49,018 | Feb 19, 2026, 04:28 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | EVP, Chief Reg. & Quality Off. | Feb 18, 2026 | Sale | $473.68 | 368 | 174,314 | 48,650 | Feb 19, 2026, 04:28 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | EVP, Chief Reg. & Quality Off. | Feb 13, 2026 | Tax Payment (Shares) | $487.76 | 3,804 | 1,855,439 | 47,632 | Feb 18, 2026, 04:43 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | EVP, Chief Reg. & Quality Off. | Feb 13, 2026 | Sale | $499.99 | 1,500 | 749,985 | 46,132 | Feb 18, 2026, 04:43 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | EVP, Chief Reg. & Quality Off. | Feb 10, 2026 | Tax Payment (Shares) | $468.41 | 2,140 | 1,002,397 | 51,902 | Feb 12, 2026, 05:08 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | EVP, Chief Reg. & Quality Off. | Feb 11, 2026 | Sale | $460.43 | 466 | 214,560 | 51,436 | Feb 12, 2026, 05:08 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | EVP, Chief Reg. & Quality Off. | Jan 07, 2026 | Sale | $474.99 | 4,500 | 2,137,455 | 42,293 | Jan 09, 2026, 04:05 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | EVP, Chief Reg. & Quality Off. | Dec 03, 2025 | Sale | $449.99 | 4,500 | 2,024,955 | 46,793 | Dec 05, 2025, 04:12 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | EVP, Chief Reg. & Quality Off. | Mar 10, 2025 | Sale | $499.99 | 3,242 | 1,620,968 | 51,239 | Mar 12, 2025, 04:10 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | EVP, Chief Reg. & Quality Off. | Mar 04, 2025 | Sale | $485.49 | 4,058 | 1,970,118 | 54,481 | Mar 06, 2025, 04:08 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | EVP, Chief Reg. & Quality Off. | Feb 26, 2025 | Tax Payment (Shares) | $479.61 | 4,962 | 2,379,825 | 59,069 | Feb 28, 2025, 04:48 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | EVP, Chief Reg. & Quality Off. | Feb 27, 2025 | Sale | $475.34 | 530 | 251,930 | 58,539 | Feb 28, 2025, 04:48 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | EVP, Chief Reg. & Quality Off. | Feb 25, 2025 | Sale | $480.95 | 354 | 170,256 | 64,031 | Feb 26, 2025, 04:15 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | EVP, Chief Reg. & Quality Off. | Feb 24, 2025 | Tax Payment (Shares) | $483.28 | 3,310 | 1,599,657 | 64,385 | Feb 26, 2025, 04:15 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | EVP, Chief Reg. & Quality Off. | Feb 10, 2025 | Tax Payment (Shares) | $467.98 | 2,143 | 1,002,881 | 64,331 | Feb 12, 2025, 04:50 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | EVP, Chief Reg. & Quality Off. | Feb 11, 2025 | Sale | $459.83 | 310 | 142,547 | 64,021 | Feb 12, 2025, 04:50 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | EVP, Chief Reg. & Quality Off. | Jun 03, 2024 | Sale | $460.00 | 2,175 | 1,000,500 | 49,098 | Jun 05, 2024, 04:08 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | EVP, Chief Reg. & Quality Off. | May 30, 2024 | Sale | $439.11 | 2,350 | 1,031,908 | 53,523 | Jun 03, 2024, 04:09 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | EVP, Chief Reg. & Quality Off. | May 31, 2024 | Sale | $445.00 | 2,250 | 1,001,250 | 51,273 | Jun 03, 2024, 04:09 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | EVP, Chief Reg. & Quality Off. | Feb 23, 2024 | Tax Payment (Shares) | $431.79 | 3,309 | 1,428,793 | 56,158 | Feb 27, 2024, 05:02 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | EVP, Chief Reg. & Quality Off. | Feb 26, 2024 | Sale | $425.70 | 354 | 150,698 | 55,804 | Feb 27, 2024, 05:02 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | EVP, Chief Reg. & Quality Off. | Feb 21, 2024 | Sale | $421.77 | 360 | 151,837 | 59,467 | Feb 23, 2024, 04:28 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | EVP, Chief Reg. & Quality Off. | Feb 20, 2024 | Sale | $420.79 | 480 | 201,979 | 59,827 | Feb 21, 2024, 04:43 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | EVP, Chief Reg. & Quality Off. | Feb 16, 2024 | Tax Payment (Shares) | $424.01 | 4,499 | 1,907,621 | 63,680 | Feb 21, 2024, 04:43 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | EVP, Chief Reg. & Quality Off. | Feb 20, 2024 | Tax Payment (Shares) | $420.58 | 3,373 | 1,418,616 | 60,307 | Feb 21, 2024, 04:43 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | EVP, Chief Reg. & Quality Off. | Feb 09, 2024 | Tax Payment (Shares) | $422.74 | 2,100 | 887,754 | 68,493 | Feb 13, 2024, 05:23 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | EVP, Chief Reg. & Quality Off. | Feb 12, 2024 | Sale | $420.24 | 314 | 131,955 | 68,179 | Feb 13, 2024, 05:23 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | EVP, Chief Reg. & Quality Off. | Aug 23, 2023 | Sale | $355.00 | 2,500 | 887,500 | 48,637 | Aug 25, 2023, 04:14 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | EVP, Chief Reg. & Quality Off. | Aug 10, 2023 | Sale | $345.79 | 5,750 | 1,988,293 | 51,137 | Aug 14, 2023, 04:08 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | EVP, Chief Reg. & Quality Off. | Feb 24, 2023 | Tax Payment (Shares) | $289.12 | 3,308 | 956,409 | 57,159 | Feb 28, 2023, 05:11 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | EVP, Chief Reg. & Quality Off. | Feb 27, 2023 | Sale | $287.48 | 354 | 101,768 | 56,876 | Feb 28, 2023, 05:11 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | EVP, Chief Reg. & Quality Off. | Feb 17, 2023 | Tax Payment (Shares) | $292.85 | 4,498 | 1,317,239 | 60,947 | Feb 22, 2023, 04:48 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | EVP, Chief Reg. & Quality Off. | Feb 21, 2023 | Sale | $293.75 | 480 | 141,002 | 60,943 | Feb 22, 2023, 04:48 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | EVP, Chief Reg. & Quality Off. | Feb 14, 2023 | Sale | $298.52 | 320 | 95,527 | 65,694 | Feb 16, 2023, 04:18 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | EVP, Chief Reg. & Quality Off. | Feb 10, 2023 | Tax Payment (Shares) | $294.33 | 1,377 | 405,292 | 69,035 | Feb 14, 2023, 05:12 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | EVP, Chief Reg. & Quality Off. | Feb 13, 2023 | Tax Payment (Shares) | $298.26 | 2,995 | 893,289 | 66,040 | Feb 14, 2023, 05:12 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | EVP, Chief Reg. & Quality Off. | Feb 13, 2023 | Sale | $298.99 | 275 | 82,223 | 66,038 | Feb 14, 2023, 05:12 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | EVP, Chief Reg. & Quality Off. | Aug 09, 2022 | Sale | $298.97 | 1,400 | 418,557 | 47,198 | Aug 10, 2022, 04:06 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | EVP, Chief Reg. & Quality Off. | Mar 17, 2022 | Sale | $250.11 | 2,833 | 708,572 | 47,390 | Mar 21, 2022, 04:15 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | EVP, Chief Reg. & Quality Off. | Feb 24, 2022 | Tax Payment (Shares) | $227.86 | 2,590 | 590,157 | 50,514 | Feb 28, 2022, 05:27 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | EVP, Chief Reg. & Quality Off. | Feb 25, 2022 | Sale | $230.95 | 325 | 75,058 | 50,486 | Feb 28, 2022, 05:27 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | EVP, Chief Reg. & Quality Off. | Feb 17, 2022 | Tax Payment (Shares) | $232.51 | 4,114 | 956,546 | 53,623 | Feb 22, 2022, 05:03 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | EVP, Chief Reg. & Quality Off. | Feb 18, 2022 | Sale | $231.00 | 519 | 119,889 | 53,405 | Feb 22, 2022, 05:03 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | EVP, Chief Reg. & Quality Off. | Feb 24, 2021 | Tax Payment (Shares) | $217.57 | 1,036 | 225,403 | 31,432 | Feb 26, 2021, 04:26 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | EVP, Chief Reg. & Quality Off. | Feb 17, 2021 | Tax Payment (Shares) | $211.75 | 2,000 | 423,500 | 32,468 | Feb 19, 2021, 04:24 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | EVP, Chief Reg. & Quality Off. | Feb 10, 2021 | Tax Payment (Shares) | $214.16 | 1,230 | 263,417 | 34,468 | Feb 12, 2021, 04:17 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | EVP, Chief Regulatory Officer | May 15, 2020 | Sale | $284.00 | 120 | 34,080 | 12,848 | May 19, 2020, 04:33 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | EVP, Chief Regulatory Officer | May 06, 2020 | Option/RSU Exercise | $174.06 | 966 | 168,146 | 13,704 | May 08, 2020, 04:28 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | EVP, Chief Regulatory Officer | May 06, 2020 | Sale | $272.70 | 966 | 263,431 | 13,661 | May 08, 2020, 04:28 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | SVP, CRO | Feb 24, 2020 | Tax Payment (Shares) | $239.23 | 1,036 | 247,842 | 14,034 | Feb 26, 2020, 04:39 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | SVP, CRO | Feb 25, 2020 | Sale | $233.17 | 1,296 | 302,187 | 13,618 | Feb 26, 2020, 04:39 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | SVP, CRO | Feb 17, 2020 | Tax Payment (Shares) | $241.50 | 597 | 144,176 | 16,349 | Feb 19, 2020, 04:39 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | SVP, CRO | Feb 18, 2020 | Sale | $243.62 | 1,279 | 311,585 | 16,189 | Feb 19, 2020, 04:39 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | SVP, CRO | Feb 06, 2020 | Option/RSU Exercise | $174.05 | 967 | 168,302 | 17,913 | Feb 07, 2020, 04:28 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | SVP, CRO | Feb 06, 2020 | Sale | $239.43 | 967 | 231,527 | 17,342 | Feb 07, 2020, 04:28 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | SVP, CRO | Jan 08, 2020 | Option/RSU Exercise | $187.53 | 1,675 | 314,113 | 8,927 | Jan 10, 2020, 04:22 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | SVP, CRO | Jan 08, 2020 | Sale | $227.53 | 1,675 | 381,113 | 7,252 | Jan 10, 2020, 04:22 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | SVP, CRO | Nov 15, 2019 | Sale | $205.95 | 5 | 1,030 | 7,252 | Nov 19, 2019, 04:17 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | SVP, CRO | Nov 13, 2019 | Option/RSU Exercise | $155.57 | 2,853 | 443,841 | 10,105 | Nov 15, 2019, 04:07 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | SVP, CRO | Nov 13, 2019 | Sale | $205.59 | 2,853 | 586,548 | 7,252 | Nov 15, 2019, 04:07 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | SVP, CRO | Oct 01, 2019 | Sale | $169.11 | 188 | 31,793 | 7,696 | Oct 03, 2019, 04:25 PM |
| VRTX | | VERTEX PHARMACEUTICALS INC / MA | Ourania Tatsis | SVP, CRO | Oct 02, 2019 | Sale | $167.69 | 444 | 74,454 | 7,252 | Oct 03, 2019, 04:25 PM |