| TARA | | Protara Therapeutics, Inc. | Opaleye Management . Inc | 10% Owner | Dec 17, 2021 | Buy | $6.60 | 490 | 3,234 | 104,200 | Dec 20, 2021, 04:00 PM |
| TARA | | Protara Therapeutics, Inc. | Opaleye Management . Inc | 10% Owner | Nov 18, 2021 | Buy | $6.98 | 1,000 | 6,979 | 102,647 | Nov 19, 2021, 04:10 PM |
| TARA | | Protara Therapeutics, Inc. | Opaleye Management . Inc | 10% Owner | Nov 18, 2021 | Buy | $6.98 | 14,206 | 99,151 | 2,486,706 | Nov 19, 2021, 04:10 PM |
| TARA | | Protara Therapeutics, Inc. | Opaleye Management . Inc | 10% Owner | Nov 17, 2021 | Buy | $6.98 | 1,090 | 7,608 | 101,647 | Nov 19, 2021, 04:10 PM |
| TARA | | Protara Therapeutics, Inc. | Opaleye Management . Inc | 10% Owner | Nov 17, 2021 | Buy | $6.98 | 8,028 | 56,035 | 2,472,500 | Nov 19, 2021, 04:10 PM |
| ETON | | Eton Pharmaceuticals, Inc. | Opaleye Management . Inc | 10% Owner | Nov 17, 2021 | Sale | $4.67 | 25,000 | 116,712 | 2,375,000 | Nov 19, 2021, 04:09 PM |
| ETON | | Eton Pharmaceuticals, Inc. | Opaleye Management . Inc | 10% Owner | Nov 16, 2021 | Sale | $4.86 | 938 | 4,560 | 85,000 | Nov 17, 2021, 04:33 PM |
| ETON | | Eton Pharmaceuticals, Inc. | Opaleye Management . Inc | 10% Owner | Nov 16, 2021 | Sale | $4.86 | 11,500 | 55,912 | 2,400,000 | Nov 17, 2021, 04:33 PM |
| ETON | | Eton Pharmaceuticals, Inc. | Opaleye Management . Inc | 10% Owner | Nov 15, 2021 | Sale | $4.80 | 500 | 2,401 | 85,938 | Nov 17, 2021, 04:33 PM |
| ETON | | Eton Pharmaceuticals, Inc. | Opaleye Management . Inc | 10% Owner | Nov 15, 2021 | Sale | $4.80 | 2,500 | 12,004 | 2,411,500 | Nov 17, 2021, 04:33 PM |
| ETON | | Eton Pharmaceuticals, Inc. | Opaleye Management . Inc | 10% Owner | Nov 05, 2021 | Sale | $6.30 | 8,401 | 52,936 | 89,099 | Nov 09, 2021, 04:46 PM |
| ETON | | Eton Pharmaceuticals, Inc. | Opaleye Management . Inc | 10% Owner | Nov 05, 2021 | Sale | $6.30 | 159,300 | 1,003,765 | 2,464,000 | Nov 09, 2021, 04:46 PM |
| ETON | | Eton Pharmaceuticals, Inc. | Opaleye Management . Inc | 10% Owner | Nov 08, 2021 | Sale | $6.10 | 2,661 | 16,235 | 86,438 | Nov 09, 2021, 04:46 PM |
| ETON | | Eton Pharmaceuticals, Inc. | Opaleye Management . Inc | 10% Owner | Nov 08, 2021 | Sale | $6.10 | 50,000 | 305,050 | 2,414,000 | Nov 09, 2021, 04:46 PM |
| TARA | | Protara Therapeutics, Inc. | Opaleye Management . Inc | 10% Owner | Nov 04, 2021 | Buy | $6.50 | 557 | 3,621 | 100,557 | Nov 08, 2021, 02:30 PM |
| TARA | | Protara Therapeutics, Inc. | Opaleye Management . Inc | 10% Owner | Nov 04, 2021 | Buy | $6.50 | 6,000 | 39,000 | 2,464,472 | Nov 08, 2021, 02:30 PM |
| ETON | | Eton Pharmaceuticals, Inc. | Opaleye Management . Inc | 10% Owner | Nov 03, 2021 | Sale | $6.53 | 110,000 | 718,399 | 2,705,000 | Nov 05, 2021, 04:13 PM |
| ETON | | Eton Pharmaceuticals, Inc. | Opaleye Management . Inc | 10% Owner | Nov 04, 2021 | Sale | $6.44 | 4,000 | 25,748 | 97,500 | Nov 05, 2021, 04:13 PM |
| ETON | | Eton Pharmaceuticals, Inc. | Opaleye Management . Inc | 10% Owner | Nov 04, 2021 | Sale | $6.44 | 81,700 | 525,903 | 2,623,300 | Nov 05, 2021, 04:13 PM |
| ETON | | Eton Pharmaceuticals, Inc. | Opaleye Management . Inc | 10% Owner | Nov 03, 2021 | Sale | $6.53 | 6,500 | 42,451 | 101,500 | Nov 05, 2021, 04:13 PM |
| ETON | | Eton Pharmaceuticals, Inc. | Opaleye Management . Inc | 10% Owner | Oct 11, 2021 | Sale | $5.01 | 1,601 | 8,015 | 112,807 | Oct 13, 2021, 07:57 AM |
| ETON | | Eton Pharmaceuticals, Inc. | Opaleye Management . Inc | 10% Owner | Oct 11, 2021 | Sale | $5.01 | 32,500 | 162,701 | 2,897,500 | Oct 13, 2021, 07:57 AM |
| ETON | | Eton Pharmaceuticals, Inc. | Opaleye Management . Inc | 10% Owner | Oct 12, 2021 | Sale | $5.06 | 4,807 | 24,308 | 117,100 | Oct 13, 2021, 07:57 AM |
| ETON | | Eton Pharmaceuticals, Inc. | Opaleye Management . Inc | 10% Owner | Oct 12, 2021 | Sale | $5.06 | 82,500 | 417,178 | 2,815,000 | Oct 13, 2021, 07:57 AM |
| ETON | | Eton Pharmaceuticals, Inc. | Opaleye Management . Inc | 10% Owner | Oct 08, 2021 | Sale | $5.00 | 2,692 | 13,461 | 114,408 | Oct 13, 2021, 07:57 AM |
| ETON | | Eton Pharmaceuticals, Inc. | Opaleye Management . Inc | 10% Owner | Oct 08, 2021 | Sale | $5.00 | 41,000 | 205,008 | 2,930,000 | Oct 13, 2021, 07:57 AM |
| HROW | | HARROW HEALTH, INC. | Opaleye Management . Inc | 10% Owner | Aug 19, 2021 | Buy | $8.44 | 2,500 | 21,112 | 150,000 | Aug 23, 2021, 05:59 PM |
| HROW | | HARROW HEALTH, INC. | Opaleye Management . Inc | 10% Owner | Aug 19, 2021 | Buy | $8.44 | 50,000 | 422,250 | 3,135,000 | Aug 23, 2021, 05:59 PM |
| HROW | | HARROW HEALTH, INC. | Opaleye Management . Inc | 10% Owner | Aug 18, 2021 | Buy | $8.64 | 1,500 | 12,967 | 147,500 | Aug 19, 2021, 07:10 PM |
| HROW | | HARROW HEALTH, INC. | Opaleye Management . Inc | 10% Owner | Aug 18, 2021 | Buy | $8.64 | 45,000 | 389,012 | 3,085,000 | Aug 19, 2021, 07:10 PM |
| HROW | | HARROW HEALTH, INC. | Opaleye Management . Inc | 10% Owner | Aug 17, 2021 | Buy | $8.57 | 1,000 | 8,566 | 146,000 | Aug 19, 2021, 07:10 PM |
| HROW | | HARROW HEALTH, INC. | Opaleye Management . Inc | 10% Owner | Aug 17, 2021 | Buy | $8.57 | 25,000 | 214,153 | 3,040,000 | Aug 19, 2021, 07:10 PM |
| ETON | | Eton Pharmaceuticals, Inc. | Opaleye Management . Inc | 10% Owner | Aug 05, 2021 | Sale | $5.85 | 150,000 | 877,980 | 3,301,100 | Aug 06, 2021, 09:53 PM |
| ETON | | Eton Pharmaceuticals, Inc. | Opaleye Management . Inc | 10% Owner | Aug 06, 2021 | Sale | $5.84 | 15,000 | 87,603 | 117,100 | Aug 06, 2021, 09:53 PM |
| ETON | | Eton Pharmaceuticals, Inc. | Opaleye Management . Inc | 10% Owner | Aug 06, 2021 | Sale | $5.84 | 330,000 | 1,927,266 | 2,971,100 | Aug 06, 2021, 09:53 PM |
| ETON | | Eton Pharmaceuticals, Inc. | Opaleye Management . Inc | 10% Owner | Aug 04, 2021 | Sale | $5.75 | 4,000 | 23,006 | 137,600 | Aug 06, 2021, 09:53 PM |
| ETON | | Eton Pharmaceuticals, Inc. | Opaleye Management . Inc | 10% Owner | Aug 04, 2021 | Sale | $5.75 | 100,000 | 575,140 | 3,451,100 | Aug 06, 2021, 09:53 PM |
| ETON | | Eton Pharmaceuticals, Inc. | Opaleye Management . Inc | 10% Owner | Aug 05, 2021 | Sale | $5.85 | 5,500 | 32,193 | 132,100 | Aug 06, 2021, 09:53 PM |
| HROW | | HARROW HEALTH, INC. | Opaleye Management . Inc | 10% Owner | Jul 21, 2021 | Buy | $7.60 | 4,706 | 35,749 | 145,000 | Jul 22, 2021, 09:19 AM |
| HROW | | HARROW HEALTH, INC. | Opaleye Management . Inc | 10% Owner | Jul 21, 2021 | Buy | $7.60 | 4,500 | 34,184 | 3,015,000 | Jul 22, 2021, 09:19 AM |
| HROW | | HARROW HEALTH, INC. | Opaleye Management . Inc | 10% Owner | Jul 19, 2021 | Buy | $6.97 | 169 | 1,178 | 140,169 | Jul 22, 2021, 09:19 AM |
| HROW | | HARROW HEALTH, INC. | Opaleye Management . Inc | 10% Owner | Jul 19, 2021 | Buy | $6.97 | 5,700 | 39,719 | 3,005,700 | Jul 22, 2021, 09:19 AM |
| HROW | | HARROW HEALTH, INC. | Opaleye Management . Inc | 10% Owner | Jul 20, 2021 | Buy | $7.20 | 125 | 900 | 140,294 | Jul 22, 2021, 09:19 AM |
| HROW | | HARROW HEALTH, INC. | Opaleye Management . Inc | 10% Owner | Jul 20, 2021 | Buy | $7.20 | 4,800 | 34,560 | 3,010,500 | Jul 22, 2021, 09:19 AM |
| HROW | | HARROW HEALTH, INC. | Opaleye Management . Inc | 10% Owner | Jun 18, 2021 | Buy | $8.35 | 59,800 | 499,282 | 3,000,000 | Jun 22, 2021, 11:44 AM |
| HROW | | HARROW HEALTH, INC. | Opaleye Management . Inc | 10% Owner | Jun 17, 2021 | Buy | $8.32 | 462 | 3,844 | 136,478 | Jun 22, 2021, 11:44 AM |
| HROW | | HARROW HEALTH, INC. | Opaleye Management . Inc | 10% Owner | Jun 17, 2021 | Buy | $8.32 | 10,800 | 89,857 | 2,940,200 | Jun 22, 2021, 11:44 AM |
| HROW | | HARROW HEALTH, INC. | Opaleye Management . Inc | 10% Owner | Jun 18, 2021 | Buy | $8.35 | 3,522 | 29,406 | 140,000 | Jun 22, 2021, 11:44 AM |
| ETON | | Eton Pharmaceuticals, Inc. | Opaleye Management . Inc | 10% Owner | Jun 15, 2021 | Sale | $8.07 | 4,000 | 32,280 | 141,600 | Jun 21, 2021, 06:05 AM |
| ETON | | Eton Pharmaceuticals, Inc. | Opaleye Management . Inc | 10% Owner | Jun 15, 2021 | Sale | $8.07 | 101,000 | 815,070 | 3,551,100 | Jun 21, 2021, 06:05 AM |
| ETON | | Eton Pharmaceuticals, Inc. | Opaleye Management . Inc | 10% Owner | May 25, 2021 | Sale | $8.53 | 2,000 | 17,060 | 153,000 | May 27, 2021, 07:34 PM |
| ETON | | Eton Pharmaceuticals, Inc. | Opaleye Management . Inc | 10% Owner | May 25, 2021 | Sale | $8.53 | 46,000 | 392,380 | 3,839,000 | May 27, 2021, 07:34 PM |
| ETON | | Eton Pharmaceuticals, Inc. | Opaleye Management . Inc | 10% Owner | May 26, 2021 | Sale | $8.57 | 2,800 | 23,996 | 150,200 | May 27, 2021, 07:34 PM |
| ETON | | Eton Pharmaceuticals, Inc. | Opaleye Management . Inc | 10% Owner | May 26, 2021 | Sale | $8.57 | 65,500 | 561,335 | 3,773,500 | May 27, 2021, 07:34 PM |
| ETON | | Eton Pharmaceuticals, Inc. | Opaleye Management . Inc | 10% Owner | May 27, 2021 | Sale | $8.49 | 4,600 | 39,054 | 145,600 | May 27, 2021, 07:34 PM |
| ETON | | Eton Pharmaceuticals, Inc. | Opaleye Management . Inc | 10% Owner | May 27, 2021 | Sale | $8.49 | 121,400 | 1,030,686 | 3,652,100 | May 27, 2021, 07:34 PM |
| HROW | | HARROW HEALTH, INC. | Opaleye Management . Inc | 10% Owner | Dec 18, 2020 | Buy | $5.31 | 35,000 | 185,941 | 2,862,100 | Dec 22, 2020, 06:09 PM |
| HROW | | HARROW HEALTH, INC. | Opaleye Management . Inc | 10% Owner | Dec 21, 2020 | Buy | $5.24 | 2,059 | 10,788 | 135,359 | Dec 22, 2020, 06:09 PM |
| HROW | | HARROW HEALTH, INC. | Opaleye Management . Inc | 10% Owner | Dec 21, 2020 | Buy | $5.24 | 51,400 | 269,305 | 2,913,500 | Dec 22, 2020, 06:09 PM |
| HROW | | HARROW HEALTH, INC. | Opaleye Management . Inc | 10% Owner | Dec 22, 2020 | Buy | $5.19 | 657 | 3,413 | 136,016 | Dec 22, 2020, 06:09 PM |
| HROW | | HARROW HEALTH, INC. | Opaleye Management . Inc | 10% Owner | Dec 22, 2020 | Buy | $5.19 | 15,900 | 82,597 | 2,929,400 | Dec 22, 2020, 06:09 PM |
| HROW | | HARROW HEALTH, INC. | Opaleye Management . Inc | 10% Owner | Dec 18, 2020 | Buy | $5.31 | 1,400 | 7,438 | 133,300 | Dec 22, 2020, 06:09 PM |
| ETON | | Eton Pharmaceuticals, Inc. | Opaleye Management . Inc | 10% Owner | Oct 16, 2020 | Buy | $7.00 | 15,000 | 105,000 | 155,000 | Oct 16, 2020, 09:30 PM |
| ETON | | Eton Pharmaceuticals, Inc. | Opaleye Management . Inc | 10% Owner | Oct 16, 2020 | Buy | $7.00 | 385,000 | 2,695,000 | 3,885,000 | Oct 16, 2020, 09:30 PM |
| TARA | | Protara Therapeutics, Inc. | Opaleye Management . Inc | 10% Owner | Sep 30, 2020 | Buy | $16.00 | 50,000 | 800,000 | 2,458,472 | Oct 02, 2020, 06:05 AM |
| "TARA" | | Protara Therapeutics, Inc. | Opaleye Management . Inc | 10% Owner | Sep 24, 2020 | Buy | $16.87 | 200,000 | 3,374,000 | 2,408,472 | Sep 25, 2020, 12:00 AM |
| "TARA" | | Protara Therapeutics, Inc. | Opaleye Management . Inc | 10% Owner | Sep 24, 2020 | Buy | $16.87 | 100,000 | 1,687,000 | 100,000 | Sep 25, 2020, 12:00 AM |
| HROW | | HARROW HEALTH, INC. | Opaleye Management . Inc | 10% Owner | Jul 10, 2020 | Buy | $4.98 | 45,000 | 223,965 | 2,761,300 | Jul 14, 2020, 09:45 PM |
| HROW | | HARROW HEALTH, INC. | Opaleye Management . Inc | 10% Owner | Jul 11, 2020 | Buy | $4.96 | 46,800 | 231,922 | 2,808,100 | Jul 14, 2020, 09:45 PM |
| HROW | | HARROW HEALTH, INC. | Opaleye Management . Inc | 10% Owner | Jul 12, 2020 | Buy | $4.98 | 1,900 | 9,462 | 131,900 | Jul 14, 2020, 09:45 PM |
| HROW | | HARROW HEALTH, INC. | Opaleye Management . Inc | 10% Owner | Jul 12, 2020 | Buy | $4.99 | 19,000 | 94,783 | 2,827,100 | Jul 14, 2020, 09:45 PM |
| HROW | | HARROW HEALTH, INC. | Opaleye Management . Inc | 10% Owner | Jul 09, 2020 | Buy | $4.84 | 25,000 | 121,000 | 2,716,300 | Jul 09, 2020, 09:30 PM |
| HROW | | HARROW HEALTH, INC. | Opaleye Management . Inc | 10% Owner | Jul 07, 2020 | Buy | $5.18 | 41,300 | 213,996 | 2,626,300 | Jul 09, 2020, 09:30 PM |
| HROW | | HARROW HEALTH, INC. | Opaleye Management . Inc | 10% Owner | Jul 08, 2020 | Buy | $4.99 | 65,000 | 324,629 | 2,691,300 | Jul 09, 2020, 09:30 PM |
| HROW | | HARROW HEALTH, INC. | Opaleye Management . Inc | 10% Owner | Jul 09, 2020 | Buy | $4.82 | 5,000 | 24,079 | 130,000 | Jul 09, 2020, 09:30 PM |
| HROW | | HARROW HEALTH, INC. | Opaleye Management . Inc | 10% Owner | Jun 19, 2020 | Buy | $5.58 | 35,000 | 195,402 | 2,585,000 | Jun 23, 2020, 09:45 PM |
| HROW | | HARROW HEALTH, INC. | Opaleye Management . Inc | 10% Owner | Jun 04, 2020 | Buy | $5.79 | 10,000 | 57,861 | 2,550,000 | Jun 04, 2020, 06:06 PM |
| HROW | | HARROW HEALTH, INC. | Opaleye Management . Inc | 10% Owner | Jun 02, 2020 | Buy | $5.69 | 19,400 | 110,339 | 2,519,400 | Jun 04, 2020, 06:06 PM |
| HROW | | HARROW HEALTH, INC. | Opaleye Management . Inc | 10% Owner | Jun 03, 2020 | Buy | $5.74 | 20,600 | 118,308 | 2,540,000 | Jun 04, 2020, 06:06 PM |
| HROW | | HARROW HEALTH, INC. | Opaleye Management . Inc | 10% Owner | May 21, 2020 | Buy | $4.66 | 10,396 | 48,399 | 2,491,196 | May 22, 2020, 07:22 PM |
| HROW | | HARROW HEALTH, INC. | Opaleye Management . Inc | 10% Owner | May 22, 2020 | Buy | $5.02 | 5,000 | 25,105 | 125,000 | May 22, 2020, 07:22 PM |
| HROW | | HARROW HEALTH, INC. | Opaleye Management . Inc | 10% Owner | May 22, 2020 | Buy | $5.05 | 8,804 | 44,484 | 2,500,000 | May 22, 2020, 07:22 PM |
| HROW | | HARROW HEALTH, INC. | Opaleye Management . Inc | 10% Owner | May 20, 2020 | Buy | $4.50 | 1,200 | 5,398 | 119,800 | May 22, 2020, 07:22 PM |
| HROW | | HARROW HEALTH, INC. | Opaleye Management . Inc | 10% Owner | May 20, 2020 | Buy | $4.47 | 300 | 1,341 | 2,480,800 | May 22, 2020, 07:22 PM |
| HROW | | HARROW HEALTH, INC. | Opaleye Management . Inc | 10% Owner | May 21, 2020 | Buy | $4.70 | 200 | 940 | 120,000 | May 22, 2020, 07:22 PM |
| OCUL | | OCULAR THERAPEUTIX, INC | Opaleye Management . Inc | 10% Owner | Jan 02, 2020 | Buy | $3.90 | 15,000 | 58,508 | 4,918,500 | Jan 03, 2020, 07:45 PM |
| OCUL | | OCULAR THERAPEUTIX, INC | Opaleye Management . Inc | 10% Owner | Dec 30, 2019 | Buy | $3.97 | 5,000 | 19,852 | 207,500 | Jan 02, 2020, 05:15 PM |
| OCUL | | OCULAR THERAPEUTIX, INC | Opaleye Management . Inc | 10% Owner | Dec 30, 2019 | Buy | $3.97 | 15,000 | 59,557 | 4,903,500 | Jan 02, 2020, 05:15 PM |
| IMMY | | Imprimis Pharmaceuticals, Inc. | Opaleye Management . Inc | 10% Owner | Mar 11, 2016 | Buy | $3.60 | 45,000 | 162,000 | 1,250,000 | Mar 14, 2016, 03:33 PM |
| IMMY | | Imprimis Pharmaceuticals, Inc. | Opaleye Management . Inc | 10% Owner | Mar 11, 2016 | Buy | $3.65 | 45,000 | 164,250 | 1,250,000 | Mar 14, 2016, 11:06 AM |
| IMMY | | Imprimis Pharmaceuticals, Inc. | Opaleye Management . Inc | 10% Owner | Mar 11, 2016 | Buy | $3.65 | 45,000 | 164,250 | 1,250,000 | Mar 14, 2016, 08:37 AM |
| IMMY | | Imprimis Pharmaceuticals, Inc. | Opaleye Management . Inc | 10% Owner | Jun 30, 2015 | Buy | $7.90 | 35,000 | 276,500 | 1,205,000 | Jun 30, 2015, 03:23 PM |
| IMMY | | Imprimis Pharmaceuticals, Inc. | Opaleye Management . Inc | 10% Owner | May 19, 2015 | Buy | $8.00 | 2,801 | 22,408 | 1,170,000 | May 20, 2015, 11:59 AM |
