| IONS | | IONIS PHARMACEUTICALS INC | Brett P. Monia | SVP, Antisense Drug Discovery | Jul 01, 2016 | Other Acquisition or Disposition | $20.76 | 309 | 6,414 | 8,002 | Jul 01, 2016, 08:20 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Brett P. Monia | SVP, Antisense Drug Discovery | Jan 19, 2016 | Sale | $41.46 | 2,208 | 91,541 | 7,693 | Jan 19, 2016, 08:09 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Brett P. Monia | SVP, Antisense Drug Discovery | Jan 15, 2016 | Option/RSU Exercise | - | 5,543 | - | 8,297 | Jan 19, 2016, 08:09 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Brett P. Monia | SVP, Antisense Drug Discovery | Jan 01, 2016 | Other Acquisition or Disposition | $47.71 | 130 | 6,202 | 4,485 | Jan 04, 2016, 09:24 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Brett P. Monia | SVP, Antisense Drug Discovery | Jan 04, 2016 | Sale | $61.00 | 127 | 7,747 | 4,358 | Jan 04, 2016, 09:24 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Brett P. Monia | SVP, Antisense Drug Discovery | Jul 01, 2015 | Other Acquisition or Disposition | $48.59 | 127 | 6,170 | 4,553 | Jul 02, 2015, 06:05 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Brett P. Monia | SVP, Antisense Drug Discovery | Jul 02, 2015 | Sale | $56.30 | 198 | 11,147 | 4,355 | Jul 02, 2015, 06:05 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Brett P. Monia | SVP, Antisense Drug Discovery | Jun 08, 2015 | Option/RSU Exercise | $10.29 | 7,600 | 78,204 | 12,026 | Jun 10, 2015, 06:36 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Brett P. Monia | SVP, Antisense Drug Discovery | Jun 08, 2015 | Sale | $66.22 | 7,600 | 503,280 | 4,426 | Jun 10, 2015, 06:36 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Brett P. Monia | SVP, Antisense Drug Discovery | Jan 16, 2015 | Sale | $67.96 | 1,534 | 104,257 | 4,426 | Jan 20, 2015, 07:57 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Brett P. Monia | SVP, Antisense Drug Discovery | Jan 15, 2015 | Option/RSU Exercise | - | 4,025 | - | 5,140 | Jan 20, 2015, 07:57 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Brett P. Monia | SVP, Antisense Drug Discovery | Jan 01, 2015 | Other Acquisition or Disposition | $30.05 | 198 | 5,949 | 2,011 | Jan 05, 2015, 07:56 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Brett P. Monia | SVP, Antisense Drug Discovery | Jan 02, 2015 | Sale | $62.75 | 76 | 4,769 | 1,935 | Jan 05, 2015, 07:56 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Brett P. Monia | SVP, Antisense Drug Discovery | Aug 26, 2014 | Option/RSU Exercise | $9.26 | 27,344 | 253,267 | 16,813 | Aug 28, 2014, 06:48 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Brett P. Monia | SVP, Antisense Drug Discovery | Aug 26, 2014 | Sale | $38.14 | 27,344 | 1,043,010 | 1,813 | Aug 28, 2014, 06:48 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Brett P. Monia | SVP, Antisense Drug Discovery | Jul 31, 2014 | Sale | $31.50 | 79 | 2,489 | 1,813 | Aug 01, 2014, 07:16 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Brett P. Monia | SVP, Antisense Drug Discovery | Jul 01, 2014 | Other Acquisition or Disposition | $30.20 | 76 | 2,295 | 1,892 | Jul 01, 2014, 08:18 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Brett P. Monia | SVP, Antisense Drug Discovery | Jan 15, 2014 | Option/RSU Exercise | - | 2,151 | - | 2,018 | Jan 17, 2014, 07:39 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Brett P. Monia | SVP, Antisense Drug Discovery | Jan 16, 2014 | Sale | $47.08 | 821 | 38,653 | 1,816 | Jan 17, 2014, 07:39 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Brett P. Monia | SVP, Antisense Drug Discovery | Jan 01, 2014 | Other Acquisition or Disposition | $24.20 | 79 | 1,912 | 848 | Jan 03, 2014, 07:58 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Brett P. Monia | SVP, Antisense Drug Discovery | Jan 02, 2014 | Sale | $39.25 | 362 | 14,210 | 486 | Jan 03, 2014, 07:58 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Brett P. Monia | SVP, Antisense Drug Discovery | Sep 20, 2013 | Sale | $35.89 | 18,281 | 656,105 | 769 | Sep 23, 2013, 07:37 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Brett P. Monia | SVP, Antisense Drug Discovery | Sep 19, 2013 | Option/RSU Exercise | $14.75 | 50,000 | 737,400 | 23,269 | Sep 23, 2013, 07:37 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Brett P. Monia | SVP, Antisense Drug Discovery | Sep 19, 2013 | Sale | $33.59 | 50,000 | 1,679,700 | 769 | Sep 23, 2013, 07:37 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Brett P. Monia | SVP, Antisense Drug Discovery | Sep 20, 2013 | Option/RSU Exercise | $11.27 | 18,281 | 206,027 | 19,050 | Sep 23, 2013, 07:37 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Brett P. Monia | SVP, Antisense Drug Discovery | Aug 26, 2013 | Sale | $25.58 | 2,909 | 74,403 | 769 | Aug 28, 2013, 07:19 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Brett P. Monia | SVP, Antisense Drug Discovery | Jul 01, 2013 | Other Acquisition or Disposition | $9.20 | 362 | 3,329 | 6,057 | Jul 03, 2013, 05:15 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Brett P. Monia | SVP, Antisense Drug Discovery | Jul 02, 2013 | Sale | $28.69 | 215 | 6,169 | 5,842 | Jul 03, 2013, 05:15 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Brett P. Monia | SVP, Antisense Drug Discovery | Jun 11, 2013 | Sale | $23.76 | 9,375 | 222,750 | 5,695 | Jun 13, 2013, 07:58 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Brett P. Monia | SVP, Antisense Drug Discovery | Jun 11, 2013 | Option/RSU Exercise | $15.75 | 9,375 | 147,656 | 15,070 | Jun 13, 2013, 07:58 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Brett P. Monia | SVP, Antisense Drug Discovery | Apr 19, 2013 | Option/RSU Exercise | $11.12 | 2,500 | 27,800 | 8,195 | Apr 23, 2013, 08:47 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Brett P. Monia | SVP, Antisense Drug Discovery | Apr 19, 2013 | Sale | $21.25 | 2,500 | 53,125 | 5,695 | Apr 23, 2013, 08:47 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Brett P. Monia | SVP, Antisense Drug Discovery | Apr 22, 2013 | Option/RSU Exercise | $11.12 | 17,000 | 189,040 | 22,695 | Apr 23, 2013, 08:47 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Brett P. Monia | SVP, Antisense Drug Discovery | Apr 22, 2013 | Sale | $21.26 | 17,000 | 361,420 | 5,695 | Apr 23, 2013, 08:47 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Brett P. Monia | SVP, Antisense Drug Discovery | Mar 05, 2013 | Option/RSU Exercise | $6.81 | 18,240 | 124,214 | 23,935 | Mar 07, 2013, 08:16 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Brett P. Monia | SVP, Antisense Drug Discovery | Mar 05, 2013 | Sale | $16.86 | 18,240 | 307,599 | 5,695 | Mar 07, 2013, 08:16 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Brett P. Monia | SVP, Antisense Drug Discovery | Jan 15, 2013 | Option/RSU Exercise | - | 737 | - | 5,816 | Jan 17, 2013, 08:38 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Brett P. Monia | SVP, Antisense Drug Discovery | Jan 16, 2013 | Sale | $14.00 | 330 | 4,620 | 5,695 | Jan 17, 2013, 08:38 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Brett P. Monia | VP, Antisense Drug Discovery | Jan 01, 2013 | Other Acquisition or Disposition | $8.87 | 215 | 1,908 | 5,599 | Jan 03, 2013, 07:46 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Brett P. Monia | VP, Antisense Drug Discovery | Jan 03, 2013 | Sale | $10.84 | 311 | 3,371 | 5,288 | Jan 03, 2013, 07:46 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Brett P. Monia | VP, Antisense Drug Discovery | Sep 06, 2012 | Option/RSU Exercise | $5.25 | 12,031 | 63,163 | 17,415 | Sep 06, 2012, 09:39 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Brett P. Monia | VP, Antisense Drug Discovery | Sep 06, 2012 | Sale | $15.25 | 12,031 | 183,473 | 5,384 | Sep 06, 2012, 09:39 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Brett P. Monia | SVP, Antisense Drug Discovery | Jul 01, 2012 | Other Acquisition or Disposition | $6.13 | 311 | 1,906 | 5,971 | Jul 03, 2012, 07:06 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Brett P. Monia | SVP, Antisense Drug Discovery | Jul 03, 2012 | Sale | $12.92 | 587 | 7,584 | 5,384 | Jul 03, 2012, 07:06 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Brett P. Monia | Senior Vice President | Jan 01, 2012 | Other Acquisition or Disposition | $6.13 | 587 | 3,597 | 5,660 | Jan 03, 2012, 05:49 PM |