| Stock | Company | % Portfolio | Shares Held | Market Value | Change in Shares | % Change | Quarter End Price | Source |
|---|---|---|---|---|---|---|---|---|
| INSM | INSMED INC | 18.52% | 865,113 | $87,064,972 | -122,040 | -12.36% | $100.64 | 13F |
| ACAD | ACADIA PHARMACEUTICALS INC | 11.76% | 2,563,209 | $55,288,418 | -100,716 | -3.78% | $21.57 | 13F |
| BMRN | BIOMARIN PHARMACEUTICAL INC | 9.83% | 840,470 | $46,200,636 | -150,737 | -15.21% | $54.97 | 13F |
| FOLD | AMICUS THERAPEUTICS INC | 6.84% | 5,610,513 | $32,148,239 | -1,734,489 | -23.61% | $5.73 | 13F |
| UTHR | UNITED THERAPEUTICS CORP | 5.84% | 95,482 | $27,436,753 | -9,746 | -9.26% | $287.35 | 13F |
| BIIB | BIOGEN INC | 5.5% | 205,759 | $25,841,273 | 836 | 0.41% | $125.59 | 13F |
| ALNY | ALNYLAM PHARMACEUTICALS INC | 5.24% | 75,535 | $24,631,208 | -7,953 | -9.53% | $326.09 | 13F |
| PTCT | PTC THERAPEUTICS INC | 4.22% | 406,469 | $19,851,946 | 2,273 | 0.56% | $48.84 | 13F |
| ANAB | ANAPTYSBIO INC | 3.84% | 812,821 | $18,044,626 | -207,892 | -20.37% | $22.2 | 13F |
| NVCR | NOVOCURE LTD | 3.64% | 962,396 | $17,130,649 | -39,665 | -3.96% | $17.8 | 13F |
| STAA | STAAR SURGICAL CO | 2.83% | 791,879 | $13,287,730 | 266,862 | 50.83% | $16.78 | 13F |
| AGIO | AGIOS PHARMACEUTICALS INC | 1.9% | 268,783 | $8,939,723 | -7,795 | -2.82% | $33.26 | 13F |
| PRTA | PROTHENA CORP PLC | 1.65% | 1,274,753 | $7,737,751 | -384,981 | -23.2% | $6.07 | 13F |
| IRON | DISC MEDICINE INC | 1.64% | 145,691 | $7,715,795 | 145,691 | New | $52.96 | 13F |
| ALGN | ALIGN TECHNOLOGY INC | 1.52% | 37,772 | $7,151,373 | No Change | $189.33 | 13F | |
| GOSS | GOSSAMER BIO INC | 1.5% | 5,739,013 | $7,058,986 | -537,880 | -8.57% | $1.23 | 13F |
| EHTH | EHEALTH INC | 1.46% | 1,577,850 | $6,863,648 | -106,486 | -6.32% | $4.35 | 13F |
| ALKS | ALKERMES PLC | 1.35% | 221,021 | $6,323,411 | -492 | -0.22% | $28.61 | 13F |
| IOVA | IOVANCE BIOTHERAPEUTICS INC | 1.25% | 3,429,329 | $5,898,446 | 218,015 | 6.79% | $1.72 | 13F |
| SNDX | SYNDAX PHARMACEUTICALS INC | 0.89% | 444,367 | $4,161,497 | No Change | $9.37 | 13F | |
| RNA | AVIDITY BIOSCIENCES INC | 0.72% | 118,886 | $3,376,362 | 118,886 | New | $28.4 | 13F |
| DNLI | DENALI THERAPEUTICS INC | 0.71% | 239,809 | $3,354,928 | 239,809 | New | $13.99 | 13F |
| MIRM | MIRUM PHARMACEUTICALS INC | 0.7% | 64,700 | $3,292,583 | No Change | $50.89 | 13F | |
| EW | EDWARDS LIFESCIENCES CORP | 0.66% | 39,473 | $3,087,183 | No Change | $78.21 | 13F | |
| TSHA | TAYSHA GENE THERAPIES INC | 0.61% | 1,246,033 | $2,878,336 | -173,435 | -12.22% | $2.31 | 13F |
| BNTX | BIONTECH SE-ADR | 0.57% | 25,206 | $2,683,683 | No Change | $106.47 | 13F | |
| DYN | DYNE THERAPEUTICS INC | 0.54% | 264,976 | $2,522,572 | -68,415 | -20.52% | $9.52 | 13F |
| CRSP | CRISPR THERAPEUTICS AG | 0.46% | 44,625 | $2,170,560 | 44,625 | New | $48.64 | 13F |
| ACRS | ACLARIS THERAPEUTICS INC | 0.42% | 1,390,028 | $1,973,840 | 614,000 | 79.12% | $1.42 | 13F |
| RARE | ULTRAGENYX PHARMACEUTICAL IN | 0.38% | 48,750 | $1,772,550 | 48,750 | New | $36.36 | 13F |
| BCYC | BICYCLE THERAPEUTICS PLC-ADR | 0.37% | 248,934 | $1,730,091 | No Change | $6.95 | 13F | |
| NBIX | NEUROCRINE BIOSCIENCES INC | 0.36% | 13,334 | $1,675,950 | No Change | $125.69 | 13F | |
| TVTX | TRAVERE THERAPEUTICS INC | 0.35% | 110,719 | $1,638,641 | No Change | $14.8 | 13F | |
| NUVB | NUVATION BIO INC | 0.32% | 772,652 | $1,506,671 | No Change | $1.95 | 13F | |
| STOK | STOKE THERAPEUTICS INC | 0.3% | 125,861 | $1,428,522 | No Change | $11.35 | 13F | |
| PYXS | PYXIS ONCOLOGY INC | 0.24% | 1,037,421 | $1,141,163 | No Change | $1.1 | 13F | |
| HUM | HUMANA INC | 0.21% | 3,985 | $974,253 | No Change | $244.48 | 13F | |
| ALDX | ALDEYRA THERAPEUTICS INC | 0.18% | 225,465 | $863,531 | No Change | $3.83 | 13F | |
| KPTI | KARYOPHARM THERAPEUTICS INC | 0.17% | 187,911 | $809,896 | 187,911 | New | $4.31 | 13F |
| VYNE | VYNE THERAPEUTICS INC PIPE | 0.16% | 445,434 | $734,966 | No Change | $1.65 | 13F | |
| ABEO | ABEONA THERAPEUTICS INC | 0.13% | 108,865 | $618,353 | No Change | $5.68 | 13F | |
| ALMS | ALUMIS INC | 0.09% | 143,437 | $430,311 | 143,437 | New | $3 | 13F |
| URGN | UROGEN PHARMA LTD | 0.07% | 24,500 | $335,650 | No Change | $13.7 | 13F | |
| AKTX | AKARI THERAPEUTICS PLC-ADR | 0.04% | 146,024 | $170,834 | No Change | $1.17 | 13F | |
| GBIO | GENERATION BIO CO | 0.01% | 150,475 | $48,167 | No Change | $0.32 | 13F | |
| SLRN | ACELYRIN INC | -1,792,895 | Exited | 13F | ||||
| TIL | INSTIL BIO INC | -11,165 | Exited | 13F | ||||
| KPTI | KARYOPHARM THERAPEUTICS INC | -324,032 | Exited | 13F | ||||
| RLMD | RELMADA THERAPEUTICS INC | -495,146 | Exited | 13F | ||||
| SRPT | SAREPTA THERAPEUTICS INC | -210,258 | Exited | 13F | ||||
| VERV | VERVE THERAPEUTICS INC | -575,817 | Exited | 13F |