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INSIDER TRANSACTIONS FOR
| Owner | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| COLA MICHAEL F | Chief Executive Officer | Jun 09, 2020 | Buy | $2.50 | 100,000 | 250,000 | 175,746 | Jun 11, 2020, 08:15 PM |
| COLA MICHAEL F | President and CEO | Dec 05, 2019 | Buy | $0.13 | 2,049,376 | 274,616 | 2,267,859 | Dec 09, 2019, 09:15 PM |
| NEIL GARRY ARTHUR | Chief Scientific Officer | Dec 05, 2019 | Buy | $0.13 | 2,049,376 | 274,616 | 2,164,150 | Dec 09, 2019, 09:12 PM |
| BARER SOL J | Director | Dec 05, 2019 | Sale | $0.13 | 4,098,752 | 549,233 | 0 | Dec 09, 2019, 09:10 PM |
| GRANO JOSEPH J JR | Director | Nov 07, 2018 | Buy | $1.15 | 21,000 | 24,150 | 56,780 | Nov 13, 2018, 04:17 PM |
| GRANO JOSEPH J JR | Director | Nov 07, 2018 | Buy | $1.17 | 21,000 | 24,570 | 27,000 | Nov 13, 2018, 04:17 PM |
| GRANO JOSEPH J JR | Director | Nov 07, 2018 | Buy | $1.16 | 26,000 | 30,212 | 75,683 | Nov 13, 2018, 04:17 PM |
| BARER SOL J | Director | Aug 15, 2018 | Buy | $0.96 | 2,551,020 | 2,448,979 | 2,551,020 | Aug 17, 2018, 04:07 PM |
| Children's Hospital of Philadelphia Foundation | 10% Owner | Aug 15, 2018 | Buy | $0.96 | 2,551,020 | 2,448,979 | 18,424,036 | Aug 17, 2018, 04:06 PM |
| COLA MICHAEL F | President and CEO | Oct 17, 2017 | Buy | $1.26 | 119,047 | 149,999 | 218,483 | Oct 18, 2017, 04:17 PM |
| BAUER EUGENE A | Director | Oct 17, 2017 | Buy | $1.26 | 19,841 | 25,000 | 165,715 | Oct 18, 2017, 04:17 PM |
| CLEMOW ALASTAIR J | Director | Oct 17, 2017 | Buy | $1.26 | 19,841 | 25,000 | 57,536 | Oct 18, 2017, 04:17 PM |
| Duncan Barbara Gayle | Director | Oct 17, 2017 | Buy | $1.26 | 59,524 | 75,000 | 59,524 | Oct 18, 2017, 04:16 PM |
| GANTZ WILBUR H | Director | Oct 17, 2017 | Buy | $1.26 | 39,683 | 50,001 | 71,073 | Oct 18, 2017, 04:16 PM |
| NEIL GARRY ARTHUR | Chief Scientific Officer | Oct 17, 2017 | Buy | $1.26 | 75,000 | 94,500 | 114,774 | Oct 18, 2017, 04:16 PM |
| GRANO JOSEPH J JR | Director | Oct 17, 2017 | Buy | $1.26 | 39,683 | 50,001 | 98,463 | Oct 18, 2017, 04:15 PM |
| BARER SOL J | Director | Oct 17, 2017 | Buy | $1.26 | 421,032 | 530,500 | 1,028,032 | Oct 18, 2017, 04:15 PM |
| HARPER PHILIP R | 10% Owner | Sep 01, 2017 | Buy | $1.20 | 83,775 | 100,530 | 4,959,819 | Sep 06, 2017, 11:21 AM |
| HARPER PHILIP R | 10% Owner | Aug 23, 2017 | Buy | $1.20 | 5,700 | 6,840 | 4,876,044 | Aug 24, 2017, 11:19 AM |
| HARPER PHILIP R | 10% Owner | Aug 22, 2017 | Buy | $1.20 | 4,661 | 5,593 | 4,870,344 | Aug 24, 2017, 11:19 AM |
| HARPER PHILIP R | 10% Owner | Aug 10, 2017 | Buy | $1.19 | 20,470 | 24,359 | 4,865,683 | Aug 14, 2017, 11:35 AM |
| BARER SOL J | Director | Apr 28, 2017 | Buy | $1.57 | 100,000 | 156,670 | 607,000 | May 01, 2017, 09:16 AM |
| BARER SOL J | Director | Apr 26, 2017 | Buy | $1.54 | 100,000 | 154,340 | 507,000 | Apr 27, 2017, 08:40 AM |
| HARPER PHILIP R | 10% Owner | Mar 24, 2017 | Buy | $1.60 | 53,826 | 86,122 | 4,845,213 | Mar 27, 2017, 02:52 PM |
| HARPER PHILIP R | 10% Owner | Mar 23, 2017 | Buy | $1.60 | 4,705 | 7,528 | 4,791,387 | Mar 27, 2017, 02:52 PM |
| HARPER PHILIP R | 10% Owner | Mar 22, 2017 | Buy | $1.79 | 1,000,000 | 1,790,000 | 4,786,682 | Mar 27, 2017, 02:52 PM |
| GRANO JOSEPH J JR | Director | Dec 08, 2016 | Buy | $5.27 | 3,000 | 15,798 | 58,780 | Dec 12, 2016, 05:22 PM |
| BARER SOL J | Director | Oct 06, 2015 | Buy | $6.50 | 153,846 | 999,999 | 153,846 | Oct 08, 2015, 04:47 PM |
| COLA MICHAEL F | President and CEO | Oct 06, 2015 | Buy | $6.50 | 38,460 | 249,990 | 99,436 | Oct 08, 2015, 04:46 PM |
| NEIL GARRY ARTHUR | Chief Scientific Officer | Oct 06, 2015 | Buy | $6.50 | 15,384 | 99,996 | 39,774 | Oct 08, 2015, 04:46 PM |
| GRANO JOSEPH J JR | Director | Oct 06, 2015 | Buy | $6.50 | 15,384 | 99,996 | 15,384 | Oct 08, 2015, 04:45 PM |
| BLECH ISAAC | Director | Sep 21, 2015 | Sale | $9.96 | 94,825 | 944,457 | 1,781,003 | Sep 23, 2015, 11:04 AM |
| BLECH ISAAC | Director | Sep 21, 2015 | Option Exercise | $4.10 | 230,357 | 944,464 | 1,875,828 | Sep 23, 2015, 11:04 AM |
| BARER SOL J | Director | Mar 20, 2015 | Buy | $8.45 | 50,000 | 422,500 | 407,000 | Mar 23, 2015, 06:05 AM |
| BAUER EUGENE A | Director | Mar 20, 2015 | Sale | $8.45 | 50,000 | 422,500 | 145,874 | Mar 23, 2015, 06:03 AM |
| BARER SOL J | Director | Feb 20, 2015 | Buy | $7.55 | 50,000 | 377,500 | 357,000 | Feb 23, 2015, 06:00 AM |
| BARER SOL J | Director | Feb 19, 2015 | Buy | $7.38 | 100,000 | 738,000 | 307,000 | Feb 23, 2015, 06:00 AM |
| MCMURRAY STEPHEN D | Director | Dec 01, 2014 | Buy | $4.10 | 2,439 | 10,000 | 96,274 | Dec 02, 2014, 09:03 AM |
| GRANO JOSEPH J JR | Director | Dec 01, 2014 | Buy | $4.10 | 48,780 | 199,998 | 55,780 | Dec 02, 2014, 09:01 AM |
| GANTZ WILBUR H | Director | Dec 01, 2014 | Buy | $4.10 | 24,390 | 99,999 | 31,390 | Dec 02, 2014, 08:58 AM |
| BARER SOL J | Director | Dec 01, 2014 | Buy | $4.10 | 365,854 | 1,500,001 | 365,854 | Dec 02, 2014, 08:54 AM |
| NEIL GARRY ARTHUR | Global Head of R&D | Dec 01, 2014 | Buy | $4.10 | 24,390 | 99,999 | 24,390 | Dec 02, 2014, 08:51 AM |
| CLEMOW ALASTAIR J T | Director | Dec 01, 2014 | Buy | $4.10 | 12,195 | 49,999 | 37,695 | Dec 02, 2014, 08:48 AM |
| Applebaum Scott | Chief Legal Officer | Dec 01, 2014 | Buy | $4.10 | 6,098 | 25,002 | 6,098 | Dec 02, 2014, 08:44 AM |
| COLA MICHAEL F | President and CEO | Dec 01, 2014 | Buy | $4.10 | 60,976 | 250,002 | 60,976 | Dec 02, 2014, 08:40 AM |
| BARER SOL J | Director | Jun 13, 2014 | Buy | $7.96 | 28,000 | 222,936 | 207,000 | Jun 16, 2014, 04:30 PM |
| BARER SOL J | Director | May 12, 2014 | Buy | $6.91 | 60,000 | 414,300 | 179,000 | May 13, 2014, 08:07 AM |
| Pearlman Andrew | Director | Feb 12, 2014 | Option Exercise | $3.14 | 11,168 | 35,068 | 51,730 | Feb 14, 2014, 04:31 PM |
| Pearlman Andrew | Director | Feb 12, 2014 | Sale | $9.00 | 11,168 | 100,512 | 40,562 | Feb 14, 2014, 04:31 PM |
| Pearlman Andrew | Director | Feb 04, 2014 | Option Exercise | $2.59 | 20,000 | 51,880 | 60,562 | Feb 06, 2014, 06:02 PM |
| Pearlman Andrew | Director | Feb 04, 2014 | Sale | $8.00 | 20,000 | 160,000 | 40,562 | Feb 06, 2014, 06:02 PM |
| Pearlman Andrew | Director | Jan 30, 2014 | Option Exercise | $3.14 | 24,500 | 76,930 | 65,062 | Jan 31, 2014, 06:29 PM |
| Pearlman Andrew | Director | Jan 29, 2014 | Option Exercise | $3.14 | 500 | 1,570 | 41,062 | Jan 31, 2014, 06:29 PM |
| Pearlman Andrew | Director | Jan 29, 2014 | Sale | $7.50 | 500 | 3,750 | 40,562 | Jan 31, 2014, 06:29 PM |
| Pearlman Andrew | Director | Jan 30, 2014 | Sale | $7.50 | 24,500 | 183,750 | 40,562 | Jan 31, 2014, 06:29 PM |
| Pearlman Andrew | Director | Jan 09, 2014 | Option Exercise | $2.60 | 34,466 | 89,720 | 75,028 | Jan 10, 2014, 05:30 PM |
| Pearlman Andrew | Director | Jan 08, 2014 | Option Exercise | $2.49 | 45,534 | 113,380 | 86,096 | Jan 10, 2014, 05:30 PM |
| Pearlman Andrew | Director | Jan 09, 2014 | Sale | $6.69 | 34,466 | 230,578 | 40,562 | Jan 10, 2014, 05:30 PM |
| Pearlman Andrew | Director | Jan 08, 2014 | Sale | $6.54 | 45,534 | 297,792 | 40,562 | Jan 10, 2014, 05:30 PM |
| CLEMOW ALASTAIR J T | Director | Dec 16, 2013 | Buy | $5.78 | 4,500 | 26,005 | 18,500 | Dec 18, 2013, 08:31 AM |
| BARER SOL J | Director | Dec 13, 2013 | Buy | $5.37 | 20,000 | 107,422 | 112,000 | Dec 16, 2013, 09:00 AM |
| DELLIO CLARENCE L | Chief Operating Officer | Dec 06, 2013 | Sale | $6.50 | 2,000 | 13,000 | 2,500 | Dec 09, 2013, 05:00 PM |
| BAUER EUGENE A | Director | Dec 03, 2013 | Sale | $6.35 | 5,000 | 31,750 | 195,874 | Dec 04, 2013, 09:29 AM |
| BAUER EUGENE A | Director | Dec 02, 2013 | Sale | $6.28 | 15,000 | 94,161 | 200,874 | Dec 04, 2013, 09:29 AM |
| BARER SOL J | Director | Dec 02, 2013 | Buy | $6.59 | 20,000 | 131,780 | 92,000 | Dec 03, 2013, 11:31 AM |
| BARER SOL J | Director | Nov 11, 2013 | Buy | $6.80 | 25,000 | 170,123 | 72,000 | Nov 12, 2013, 06:00 PM |
| BARER SOL J | Director | Sep 20, 2013 | Buy | $6.50 | 20,000 | 129,996 | 47,000 | Sep 20, 2013, 12:43 PM |
| BARER SOL J | Director | Sep 19, 2013 | Buy | $5.57 | 20,000 | 111,478 | 27,000 | Sep 19, 2013, 03:22 PM |
| DELLIO CLARENCE L | Chief Operating Officer | Jun 04, 2013 | Buy | $4.14 | 712 | 2,948 | 4,500 | Jun 05, 2013, 04:02 PM |
| DELLIO CLARENCE L | Chief Operating Officer | Jun 03, 2013 | Buy | $4.14 | 288 | 1,192 | 3,788 | Jun 05, 2013, 04:02 PM |
| DELLIO CLARENCE L | Chief Operating Officer | Mar 20, 2013 | Option Exercise | $3.64 | 3,500 | 12,740 | 3,500 | Mar 22, 2013, 04:01 PM |
| Bellomo Stephen | See Remarks | Sep 20, 2012 | Sale | $10.99 | 350 | 3,846 | 0 | Sep 27, 2012, 04:04 PM |
| Bellin Phyllis K. | See Remarks | Sep 21, 2012 | Sale | $10.90 | 400 | 4,360 | 10,664 | Sep 27, 2012, 04:02 PM |
| Bellin Phyllis K. | See Remarks | Sep 20, 2012 | Sale | $10.92 | 5,082 | 55,495 | 11,064 | Sep 27, 2012, 04:02 PM |
| Pearlman Andrew | President and CEO | Sep 18, 2012 | Sale | $10.24 | 5,000 | 51,200 | 33,562 | Sep 19, 2012, 04:01 PM |
| Pearlman Andrew | President and CEO | Sep 17, 2012 | Sale | $10.29 | 6,000 | 61,740 | 38,562 | Sep 19, 2012, 04:01 PM |
| DELLIO CLARENCE L | Chief Operating Officer | Sep 14, 2012 | Sale | $10.74 | 3,007 | 32,295 | 0 | Sep 18, 2012, 04:02 PM |
| Pearlman Andrew | President and CEO | Sep 14, 2012 | Sale | $10.73 | 4,000 | 42,920 | 44,562 | Sep 17, 2012, 04:02 PM |
| Pearlman Andrew | President and CEO | Sep 13, 2012 | Sale | $10.66 | 19,623 | 209,181 | 48,562 | Sep 17, 2012, 04:02 PM |
| Bellin Phyllis K. | See Remarks | Sep 11, 2012 | Option Exercise | $12.10 | 8,482 | 102,632 | 16,146 | Sep 13, 2012, 04:04 PM |
| Bellin Phyllis K. | See Remarks | Sep 11, 2012 | Option Exercise | $7.35 | 13,964 | 102,635 | 24,628 | Sep 13, 2012, 04:04 PM |
| Pearlman Andrew | President and CEO | Sep 11, 2012 | Option Exercise | $11.83 | 56,780 | 671,707 | 68,185 | Sep 13, 2012, 04:03 PM |
| Pearlman Andrew | President and CEO | Sep 11, 2012 | Option Exercise | $7.35 | 91,403 | 671,812 | 124,965 | Sep 13, 2012, 04:03 PM |
| DELLIO CLARENCE L | Chief Operating Officer | Sep 11, 2012 | Option Exercise | $12.10 | 1,293 | 15,645 | 3,007 | Sep 13, 2012, 04:01 PM |
| DELLIO CLARENCE L | Chief Operating Officer | Sep 11, 2012 | Option Exercise | $3.64 | 4,300 | 15,652 | 4,300 | Sep 13, 2012, 04:01 PM |
| Bellomo Stephen | See Remarks | Sep 10, 2012 | Option Exercise | $12.10 | 541 | 6,546 | 350 | Sep 12, 2012, 04:05 PM |
| Bellomo Stephen | See Remarks | Sep 10, 2012 | Option Exercise | $7.35 | 891 | 6,549 | 891 | Sep 12, 2012, 04:05 PM |
| KANTER JOEL S | Director | Aug 30, 2012 | Sale | $13.03 | 700 | 9,121 | 105,804 | Sep 04, 2012, 04:02 PM |
| MCMURRAY STEPHEN D | Director | Aug 24, 2012 | Sale | $12.50 | 10,935 | 136,688 | 79,835 | Aug 28, 2012, 04:04 PM |
| BAUER EUGENE A | Director | Aug 22, 2012 | Option Exercise | $10.64 | 56,871 | 605,107 | 215,874 | Aug 24, 2012, 04:01 PM |
| BAUER EUGENE A | Director | Aug 22, 2012 | Option Exercise | $7.35 | 82,327 | 605,103 | 272,745 | Aug 24, 2012, 04:01 PM |
| MCMURRAY STEPHEN D | Director | Aug 17, 2012 | Option Exercise | $10.98 | 22,117 | 242,845 | 90,770 | Aug 21, 2012, 04:02 PM |
| MCMURRAY STEPHEN D | Director | Aug 17, 2012 | Option Exercise | $7.35 | 33,052 | 242,932 | 112,887 | Aug 21, 2012, 04:02 PM |
| KANTER JOEL S | Director | Aug 17, 2012 | Option Exercise | $7.35 | 38,803 | 285,202 | 106,504 | Aug 20, 2012, 04:03 PM |
| KANTER JOEL S | Director | Aug 16, 2012 | Option Exercise | $7.35 | 10,000 | 73,500 | 67,701 | Aug 20, 2012, 04:03 PM |
| KANTER JOEL S | Director | Jun 21, 2012 | Option Exercise | $6.55 | 4,286 | 28,073 | 57,701 | Jun 22, 2012, 12:38 PM |
| BLECH ISAAC | 10% Owner | Apr 13, 2011 | Option Exercise | $3.40 | 645,471 | 2,197,829 | 645,471 | Dec 01, 2011, 10:30 AM |
| BRUKARDT GARY A | Director | Sep 07, 2011 | Option Exercise | $3.86 | 29,504 | 113,797 | 66,077 | Oct 04, 2011, 02:58 PM |
| BRUKARDT GARY A | Director | Sep 07, 2011 | Option Exercise | $2.49 | 45,701 | 113,795 | 95,581 | Oct 04, 2011, 02:58 PM |
| BRUKARDT GARY A | Director | May 24, 2011 | Option Exercise | $3.57 | 42,238 | 150,663 | 49,880 | Jun 01, 2011, 08:27 PM |
| BRUKARDT GARY A | Director | May 24, 2011 | Option Exercise | $2.49 | 60,507 | 150,662 | 92,118 | Jun 01, 2011, 08:27 PM |
| Stern Baruch | Chief Scientific Officer | May 11, 2011 | Option Exercise | $3.98 | 30,598 | 121,780 | 29,726 | May 18, 2011, 05:15 PM |
| Stern Baruch | Chief Scientific Officer | May 11, 2011 | Option Exercise | $2.49 | 48,895 | 121,749 | 60,324 | May 18, 2011, 05:15 PM |
| BLECH ISAAC | 10% Owner | Apr 13, 2011 | Option Exercise | $3.40 | 644,053 | 2,193,000 | 1,644,053 | Apr 15, 2011, 05:27 PM |
| BLECH ISAAC | 10% Owner | Apr 13, 2011 | Buy | $5.00 | 1,000,000 | 5,000,000 | 1,000,000 | Apr 15, 2011, 05:27 PM |
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Buy
Sale
Option Exercise
| Owner | Relationship | Date | Value($) |
| COLA MICHAEL F | Chief Executive Officer | 06/09/2020 | 250,000 |
| COLA MICHAEL F | President and CEO | 12/05/2019 | 274,616 |
| NEIL GARRY ARTHUR | Chief Scientific Officer | 12/05/2019 | 274,616 |
| BARER SOL J | Director | 12/05/2019 | 549,233 |
| GRANO JOSEPH J JR | Director | 11/07/2018 | 24,150 |
| GRANO JOSEPH J JR | Director | 11/07/2018 | 24,570 |
| GRANO JOSEPH J JR | Director | 11/07/2018 | 30,212 |
| BARER SOL J | Director | 08/15/2018 | 2,448,979 |
| Children's Hospital of Philadelphia Foundation | 10% Owner | 08/15/2018 | 2,448,979 |
| COLA MICHAEL F | President and CEO | 10/17/2017 | 149,999 |
| BAUER EUGENE A | Director | 10/17/2017 | 25,000 |
| CLEMOW ALASTAIR J | Director | 10/17/2017 | 25,000 |
| Duncan Barbara Gayle | Director | 10/17/2017 | 75,000 |
| GANTZ WILBUR H | Director | 10/17/2017 | 50,001 |
| NEIL GARRY ARTHUR | Chief Scientific Officer | 10/17/2017 | 94,500 |
| GRANO JOSEPH J JR | Director | 10/17/2017 | 50,001 |
| BARER SOL J | Director | 10/17/2017 | 530,500 |
| HARPER PHILIP R | 10% Owner | 09/01/2017 | 100,530 |
| HARPER PHILIP R | 10% Owner | 08/23/2017 | 6,840 |
| HARPER PHILIP R | 10% Owner | 08/22/2017 | 5,593 |
| HARPER PHILIP R | 10% Owner | 08/10/2017 | 24,359 |
| BARER SOL J | Director | 04/28/2017 | 156,670 |
| BARER SOL J | Director | 04/26/2017 | 154,340 |
| HARPER PHILIP R | 10% Owner | 03/24/2017 | 86,122 |
| HARPER PHILIP R | 10% Owner | 03/23/2017 | 7,528 |
| HARPER PHILIP R | 10% Owner | 03/22/2017 | 1,790,000 |
| GRANO JOSEPH J JR | Director | 12/08/2016 | 15,798 |
| BARER SOL J | Director | 10/06/2015 | 999,999 |
| COLA MICHAEL F | President and CEO | 10/06/2015 | 249,990 |
| NEIL GARRY ARTHUR | Chief Scientific Officer | 10/06/2015 | 99,996 |
| GRANO JOSEPH J JR | Director | 10/06/2015 | 99,996 |
| BLECH ISAAC | Director | 09/21/2015 | 944,457 |
| BLECH ISAAC | Director | 09/21/2015 | 944,464 |
| BARER SOL J | Director | 03/20/2015 | 422,500 |
| BAUER EUGENE A | Director | 03/20/2015 | 422,500 |
| BARER SOL J | Director | 02/20/2015 | 377,500 |
| BARER SOL J | Director | 02/19/2015 | 738,000 |
| MCMURRAY STEPHEN D | Director | 12/01/2014 | 10,000 |
| GRANO JOSEPH J JR | Director | 12/01/2014 | 199,998 |
| GANTZ WILBUR H | Director | 12/01/2014 | 99,999 |
| BARER SOL J | Director | 12/01/2014 | 1,500,001 |
| NEIL GARRY ARTHUR | Global Head of R&D | 12/01/2014 | 99,999 |
| CLEMOW ALASTAIR J T | Director | 12/01/2014 | 49,999 |
| Applebaum Scott | Chief Legal Officer | 12/01/2014 | 25,002 |
| COLA MICHAEL F | President and CEO | 12/01/2014 | 250,002 |
| BARER SOL J | Director | 06/13/2014 | 222,936 |
| BARER SOL J | Director | 05/12/2014 | 414,300 |
| Pearlman Andrew | Director | 02/12/2014 | 35,068 |
| Pearlman Andrew | Director | 02/12/2014 | 100,512 |
| Pearlman Andrew | Director | 02/04/2014 | 51,880 |
| Pearlman Andrew | Director | 02/04/2014 | 160,000 |
| Pearlman Andrew | Director | 01/30/2014 | 76,930 |
| Pearlman Andrew | Director | 01/29/2014 | 1,570 |
| Pearlman Andrew | Director | 01/29/2014 | 3,750 |
| Pearlman Andrew | Director | 01/30/2014 | 183,750 |
| Pearlman Andrew | Director | 01/09/2014 | 89,720 |
| Pearlman Andrew | Director | 01/08/2014 | 113,380 |
| Pearlman Andrew | Director | 01/09/2014 | 230,578 |
| Pearlman Andrew | Director | 01/08/2014 | 297,792 |
| CLEMOW ALASTAIR J T | Director | 12/16/2013 | 26,005 |
| BARER SOL J | Director | 12/13/2013 | 107,422 |
| DELLIO CLARENCE L | Chief Operating Officer | 12/06/2013 | 13,000 |
| BAUER EUGENE A | Director | 12/03/2013 | 31,750 |
| BAUER EUGENE A | Director | 12/02/2013 | 94,161 |
| BARER SOL J | Director | 12/02/2013 | 131,780 |
| BARER SOL J | Director | 11/11/2013 | 170,123 |
| BARER SOL J | Director | 09/20/2013 | 129,996 |
| BARER SOL J | Director | 09/19/2013 | 111,478 |
| DELLIO CLARENCE L | Chief Operating Officer | 06/04/2013 | 2,948 |
| DELLIO CLARENCE L | Chief Operating Officer | 06/03/2013 | 1,192 |
| DELLIO CLARENCE L | Chief Operating Officer | 03/20/2013 | 12,740 |
| Bellomo Stephen | See Remarks | 09/20/2012 | 3,846 |
| Bellin Phyllis K. | See Remarks | 09/21/2012 | 4,360 |
| Bellin Phyllis K. | See Remarks | 09/20/2012 | 55,495 |
| Pearlman Andrew | President and CEO | 09/18/2012 | 51,200 |
| Pearlman Andrew | President and CEO | 09/17/2012 | 61,740 |
| DELLIO CLARENCE L | Chief Operating Officer | 09/14/2012 | 32,295 |
| Pearlman Andrew | President and CEO | 09/14/2012 | 42,920 |
| Pearlman Andrew | President and CEO | 09/13/2012 | 209,181 |
| Bellin Phyllis K. | See Remarks | 09/11/2012 | 102,632 |
| Bellin Phyllis K. | See Remarks | 09/11/2012 | 102,635 |
| Pearlman Andrew | President and CEO | 09/11/2012 | 671,707 |
| Pearlman Andrew | President and CEO | 09/11/2012 | 671,812 |
| DELLIO CLARENCE L | Chief Operating Officer | 09/11/2012 | 15,645 |
| DELLIO CLARENCE L | Chief Operating Officer | 09/11/2012 | 15,652 |
| Bellomo Stephen | See Remarks | 09/10/2012 | 6,546 |
| Bellomo Stephen | See Remarks | 09/10/2012 | 6,549 |
| KANTER JOEL S | Director | 08/30/2012 | 9,121 |
| MCMURRAY STEPHEN D | Director | 08/24/2012 | 136,688 |
| BAUER EUGENE A | Director | 08/22/2012 | 605,107 |
| BAUER EUGENE A | Director | 08/22/2012 | 605,103 |
| MCMURRAY STEPHEN D | Director | 08/17/2012 | 242,845 |
| MCMURRAY STEPHEN D | Director | 08/17/2012 | 242,932 |
| KANTER JOEL S | Director | 08/17/2012 | 285,202 |
| KANTER JOEL S | Director | 08/16/2012 | 73,500 |
| KANTER JOEL S | Director | 06/21/2012 | 28,073 |
| BLECH ISAAC | 10% Owner | 04/13/2011 | 2,197,829 |
| BRUKARDT GARY A | Director | 09/07/2011 | 113,797 |
| BRUKARDT GARY A | Director | 09/07/2011 | 113,795 |
| BRUKARDT GARY A | Director | 05/24/2011 | 150,663 |
| BRUKARDT GARY A | Director | 05/24/2011 | 150,662 |
| Stern Baruch | Chief Scientific Officer | 05/11/2011 | 121,780 |
| Stern Baruch | Chief Scientific Officer | 05/11/2011 | 121,749 |
| BLECH ISAAC | 10% Owner | 04/13/2011 | 2,193,000 |
| BLECH ISAAC | 10% Owner | 04/13/2011 | 5,000,000 |
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