La Jolla Pharmaceutical Co.. (LJPC) NASDAQ
$6.22 - (-)
Market Cap: -
As of 08/19/22 04:00 PM EDT. Market closed.
La Jolla Pharmaceutical Co.. (LJPC)
NASDAQ
$6.22
- (-)
Market Cap: -
As of 08/19/22 04:00 PM EDT. Market closed.
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La Jolla Pharmaceutical Company is dedicated to the development and commercialization of innovative therapies that improve outcomes in patients suffering from life-threatening diseases. In December 2017, GIAPREZA™ (angiotensin II) was approved by the U.S. Food and Drug Administration (FDA) as a vasoconstrictor indicated to increase blood pressure in adults with septic or other distributive ... read more
COMPANY PROFILE
Sector
Manufacturing
Industry
Biological Product (except Diagnostic) Manufacturing
CEO Compensation (Base)
$589,000
CEO Compensation (Total)
$1.51M
Sector
Manufacturing
Industry
Biological Product (except Diagnostic) Manufacturing
Full Time Employees
59
CEO Compensation (Base)
$589,000
CEO Compensation (Total)
$1.51M
Address
4550 Towne Centre Ct, California, San Diego, 92121-1900.
PRICE CHART FOR LA JOLLA PHARMACEUTICAL CO.
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NEWS
INSIDEARBITRAGE ARTICLES
KEY STATS
Open
-
Previous Close
$6.22
Days Range
$6.20 - $6.24
52 week range
- - -
Volume
0
Avg. Volume (30 days)
0
Market Cap
-
Dividend Yield
-
P/E
-
Shares Outstanding
24,936,883
Open
-
Previous Close
$6.22
Days Range
$6.20 - $6.24
52 week range
- - -
Volume
0
Avg. Volume (30 days)
0
Market Cap
-
Dividend Yield
-
P/E
-
Shares Outstanding
24,936,883
FINANCIAL STATEMENTS FOR LA JOLLA PHARMACEUTICAL CO.
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INSIDER TRANSACTIONS FOR LA JOLLA PHARMACEUTICAL CO.
| Owner | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| RAMSAY DAVID A | Director | Aug 22, 2022 | Option Exercise | $6.23 | 100,000 | 623,000 | 0 | Aug 24, 2022, 08:22 PM |
| TANG KEVIN C | Director | Aug 22, 2022 | Option Exercise | $6.23 | 9,607,934 | 59,857,429 | 0 | Aug 24, 2022, 08:21 PM |
| Edwards Larry G. | Chief Executive Officer | Aug 22, 2022 | Option Exercise | $6.23 | 11,969 | 74,567 | 0 | Aug 24, 2022, 08:20 PM |
| Johnson Laura L. | Director | Aug 22, 2022 | Option Exercise | $6.23 | 500 | 3,115 | 0 | Aug 24, 2022, 08:18 PM |
| Johnson Craig A | Director | Aug 22, 2022 | Option Exercise | $6.23 | 12,000 | 74,760 | 0 | Aug 24, 2022, 08:17 PM |
| Hearne Michael S | Chief Financial Officer | Aug 22, 2022 | Option Exercise | $6.23 | 10,186 | 63,459 | 0 | Aug 24, 2022, 08:17 PM |
| Hearne Michael S | Chief Financial Officer | Aug 22, 2022 | Option Exercise | $6.23 | 9,607,934 | 59,857,429 | 0 | Aug 24, 2022, 08:17 PM |
| TANG KEVIN C | Director | Aug 22, 2022 | Option Exercise | $6.23 | 9,607,934 | 59,857,429 | 0 | Aug 24, 2022, 04:02 PM |
| Johnson Craig A | Director | Jul 08, 2022 | Option Exercise | $3.93 | 12,000 | 47,160 | 12,000 | Jul 12, 2022, 08:36 PM |
| Hearne Michael S | Chief Financial Officer | Jun 30, 2022 | Option Exercise | $2.71 | 236 | 640 | 10,186 | Jul 05, 2022, 05:51 PM |
| Hearne Michael S | Chief Financial Officer | Jun 15, 2022 | Option Exercise | $2.72 | 236 | 642 | 9,950 | Jun 17, 2022, 05:05 PM |
| Hearne Michael S | Chief Financial Officer | May 31, 2022 | Option Exercise | $3.41 | 189 | 644 | 9,714 | Jun 02, 2022, 05:05 PM |
| Hearne Michael S | Chief Financial Officer | May 13, 2022 | Option Exercise | $3.41 | 188 | 641 | 9,525 | May 17, 2022, 05:07 PM |
| Hearne Michael S | Chief Financial Officer | Apr 29, 2022 | Option Exercise | $3.47 | 185 | 642 | 9,337 | May 03, 2022, 05:00 PM |
| Edwards Larry G. | Chief Executive Officer | Apr 14, 2022 | Option Exercise | $3.71 | 296 | 1,099 | 11,969 | Apr 18, 2022, 06:32 PM |
| Hearne Michael S | Chief Financial Officer | Apr 14, 2022 | Option Exercise | $3.71 | 173 | 643 | 9,152 | Apr 18, 2022, 06:31 PM |
| Edwards Larry G. | Chief Executive Officer | Mar 31, 2022 | Option Exercise | $3.63 | 334 | 1,212 | 11,673 | Apr 04, 2022, 05:39 PM |
| Hearne Michael S | Chief Financial Officer | Mar 31, 2022 | Option Exercise | $3.63 | 177 | 642 | 8,979 | Apr 04, 2022, 05:38 PM |
| Edwards Larry G. | Chief Executive Officer | Mar 15, 2022 | Option Exercise | $3.37 | 361 | 1,215 | 11,339 | Mar 17, 2022, 09:06 PM |
| Hearne Michael S | Chief Financial Officer | Mar 15, 2022 | Option Exercise | $3.37 | 190 | 640 | 8,802 | Mar 17, 2022, 09:04 PM |
| Edwards Larry G. | Chief Executive Officer | Feb 28, 2022 | Option Exercise | $3.48 | 350 | 1,217 | 10,978 | Mar 02, 2022, 05:08 PM |
| Hearne Michael S | Chief Financial Officer | Feb 28, 2022 | Option Exercise | $3.48 | 185 | 643 | 8,612 | Mar 02, 2022, 05:07 PM |
| Edwards Larry G. | Chief Executive Officer | Feb 15, 2022 | Option Exercise | $3.79 | 320 | 1,213 | 10,628 | Feb 17, 2022, 05:10 PM |
| Hearne Michael S | Chief Financial Officer | Feb 15, 2022 | Option Exercise | $3.79 | 169 | 641 | 8,427 | Feb 17, 2022, 05:05 PM |
| Edwards Larry G. | Chief Executive Officer | Jan 31, 2022 | Option Exercise | $3.94 | 4,170 | 16,411 | 10,308 | Feb 02, 2022, 07:21 PM |
| Hearne Michael S | Chief Financial Officer | Jan 31, 2022 | Option Exercise | $3.94 | 1,675 | 6,592 | 8,258 | Feb 02, 2022, 07:19 PM |
| Edwards Larry G. | Chief Executive Officer | Jan 14, 2022 | Option Exercise | $4.18 | 273 | 1,142 | 6,138 | Jan 19, 2022, 08:27 PM |
| Hearne Michael S | Chief Financial Officer | Jan 14, 2022 | Option Exercise | $4.18 | 148 | 619 | 6,583 | Jan 19, 2022, 08:26 PM |
| Edwards Larry G. | Chief Executive Officer | Dec 30, 2021 | Option Exercise | $3.92 | 233 | 913 | 5,865 | Jan 04, 2022, 05:10 PM |
| Edwards Larry G. | Chief Executive Officer | Dec 15, 2021 | Option Exercise | $3.58 | 320 | 1,145 | 5,632 | Dec 17, 2021, 06:01 PM |
| Hearne Michael S | Chief Financial Officer | Dec 15, 2021 | Option Exercise | $3.58 | 173 | 619 | 6,278 | Dec 17, 2021, 05:58 PM |
| RAMSAY DAVID A | Director | Dec 03, 2021 | Buy | $3.66 | 4,399 | 16,082 | 90,000 | Dec 06, 2021, 09:01 PM |
| RAMSAY DAVID A | Director | Dec 02, 2021 | Buy | $3.73 | 10,101 | 37,677 | 85,601 | Dec 06, 2021, 09:01 PM |
| RAMSAY DAVID A | Director | Dec 06, 2021 | Buy | $3.82 | 10,000 | 38,231 | 100,000 | Dec 06, 2021, 09:01 PM |
| Edwards Larry G. | Chief Executive Officer | Nov 30, 2021 | Option Exercise | $3.32 | 346 | 1,147 | 5,312 | Dec 02, 2021, 05:10 PM |
| Hearne Michael S | Chief Financial Officer | Nov 30, 2021 | Option Exercise | $3.32 | 186 | 617 | 6,105 | Dec 02, 2021, 05:05 PM |
| TANG KEVIN C | Director | Dec 01, 2021 | Sale | $3.74 | 177,545 | 663,431 | 9,649,224 | Dec 01, 2021, 07:07 PM |
| TANG KEVIN C | Director | Nov 30, 2021 | Sale | $3.95 | 70,342 | 277,612 | 9,849,224 | Dec 01, 2021, 07:07 PM |
| TANG KEVIN C | Director | Nov 29, 2021 | Sale | $4.10 | 193,403 | 793,107 | 9,855,821 | Dec 01, 2021, 07:07 PM |
| RAMSAY DAVID A | Director | Nov 17, 2021 | Buy | $4.23 | 7,500 | 31,725 | 75,500 | Nov 19, 2021, 05:05 PM |
| Edwards Larry G. | Chief Executive Officer | Nov 15, 2021 | Option Exercise | $3.41 | 336 | 1,145 | 4,966 | Nov 17, 2021, 05:10 PM |
| Hearne Michael S | Chief Financial Officer | Nov 15, 2021 | Option Exercise | $3.41 | 181 | 617 | 5,919 | Nov 17, 2021, 05:05 PM |
| Edwards Larry G. | Chief Executive Officer | Oct 29, 2021 | Option Exercise | $3.42 | 335 | 1,145 | 4,630 | Nov 02, 2021, 05:10 PM |
| Hearne Michael S | Chief Financial Officer | Oct 29, 2021 | Option Exercise | $3.42 | 181 | 618 | 5,738 | Nov 02, 2021, 05:05 PM |
| Edwards Larry G. | Chief Executive Officer | Oct 15, 2021 | Option Exercise | $3.37 | 341 | 1,148 | 4,295 | Oct 19, 2021, 05:10 PM |
| Hearne Michael S | Chief Financial Officer | Oct 15, 2021 | Option Exercise | $3.37 | 183 | 616 | 5,557 | Oct 19, 2021, 05:05 PM |
| Edwards Larry G. | Chief Executive Officer | Sep 30, 2021 | Option Exercise | $3.39 | 338 | 1,146 | 3,954 | Oct 04, 2021, 05:10 PM |
| Hearne Michael S | Chief Financial Officer | Sep 30, 2021 | Option Exercise | $3.39 | 182 | 617 | 5,374 | Oct 04, 2021, 05:05 PM |
| Edwards Larry G. | Chief Executive Officer | Sep 15, 2021 | Option Exercise | $3.39 | 338 | 1,146 | 3,616 | Sep 17, 2021, 05:05 PM |
| Hearne Michael S | Chief Financial Officer | Sep 15, 2021 | Option Exercise | $3.39 | 546 | 1,852 | 5,192 | Sep 17, 2021, 05:05 PM |
| Edwards Larry G. | Chief Executive Officer | Aug 31, 2021 | Option Exercise | $3.58 | 320 | 1,145 | 3,278 | Sep 02, 2021, 05:05 PM |
| Edwards Larry G. | Chief Executive Officer | Aug 13, 2021 | Option Exercise | $3.38 | 338 | 1,143 | 2,958 | Aug 17, 2021, 05:05 PM |
| Edwards Larry G. | Chief Executive Officer | Jul 30, 2021 | Option Exercise | $3.07 | 374 | 1,148 | 2,620 | Aug 03, 2021, 05:10 PM |
| Hearne Michael S | Chief Financial Officer | Jul 30, 2021 | Option Exercise | $3.07 | 201 | 617 | 4,646 | Aug 03, 2021, 05:05 PM |
| Hearne Michael S | Chief Financial Officer | Jul 15, 2021 | Option Exercise | $3.20 | 193 | 617 | 4,445 | Jul 19, 2021, 06:57 PM |
| Edwards Larry G. | Chief Executive Officer | Jul 15, 2021 | Option Exercise | $3.20 | 358 | 1,144 | 2,246 | Jul 19, 2021, 06:50 PM |
| Edwards Larry G. | Chief Executive Officer | Jun 30, 2021 | Option Exercise | $3.64 | 315 | 1,146 | 1,888 | Jul 02, 2021, 08:46 PM |
| Hearne Michael S | Chief Financial Officer | Jun 30, 2021 | Option Exercise | $3.64 | 170 | 618 | 4,252 | Jul 02, 2021, 08:35 PM |
| Edwards Larry G. | Chief Executive Officer | May 28, 2021 | Option Exercise | $3.65 | 314 | 1,148 | 1,298 | Jun 02, 2021, 05:07 PM |
| Edwards Larry G. | Chief Executive Officer | May 14, 2021 | Option Exercise | $3.20 | 358 | 1,144 | 984 | May 18, 2021, 08:29 PM |
| Hearne Michael S | Chief Financial Officer | May 14, 2021 | Option Exercise | $3.20 | 193 | 617 | 3,765 | May 18, 2021, 08:26 PM |
| Edwards Larry G. | Chief Executive Officer | Apr 15, 2021 | Option Exercise | $3.55 | 322 | 1,144 | 322 | Apr 19, 2021, 09:41 PM |
| Hearne Michael S | Chief Financial Officer | Apr 15, 2021 | Option Exercise | $3.55 | 173 | 615 | 3,835 | Apr 19, 2021, 09:38 PM |
| Hearne Michael S | Chief Financial Officer | Mar 15, 2021 | Option Exercise | $4.85 | 127 | 616 | 3,490 | Mar 17, 2021, 04:43 PM |
| Hearne Michael S | Chief Financial Officer | Feb 26, 2021 | Option Exercise | $4.45 | 139 | 619 | 3,363 | Mar 02, 2021, 04:36 PM |
| Hearne Michael S | Chief Financial Officer | Feb 12, 2021 | Option Exercise | $5.70 | 535 | 3,051 | 3,224 | Feb 18, 2021, 04:24 PM |
| Hearne Michael S | Chief Financial Officer | Jan 29, 2021 | Option Exercise | $5.20 | 118 | 614 | 2,689 | Feb 02, 2021, 05:21 PM |
| Hearne Michael S | Chief Financial Officer | Jan 15, 2021 | Option Exercise | $4.55 | 136 | 618 | 2,571 | Feb 02, 2021, 05:20 PM |
| Hearne Michael S | Chief Financial Officer | Dec 31, 2020 | Option Exercise | $3.30 | 1,648 | 5,435 | 2,435 | Feb 02, 2021, 05:18 PM |
| Hearne Michael S | Chief Financial Officer | Jan 15, 2021 | Option Exercise | $4.55 | 136 | 618 | 1,094 | Jan 20, 2021, 04:57 PM |
| Hearne Michael S | Chief Financial Officer | Dec 31, 2020 | Option Exercise | $3.30 | 171 | 564 | 958 | Jan 05, 2021, 04:32 PM |
| Hearne Michael S | Chief Financial Officer | Dec 15, 2020 | Option Exercise | $3.83 | 147 | 562 | 787 | Dec 16, 2020, 04:22 PM |
| Hearne Michael S | Chief Financial Officer | Nov 30, 2020 | Option Exercise | $4.22 | 134 | 566 | 640 | Dec 02, 2020, 04:21 PM |
| Hearne Michael S | Chief Financial Officer | Nov 13, 2020 | Option Exercise | $3.98 | 141 | 561 | 506 | Nov 17, 2020, 04:13 PM |
| Hearne Michael S | Chief Financial Officer | Oct 30, 2020 | Option Exercise | $2.89 | 196 | 566 | 365 | Nov 05, 2020, 04:59 PM |
| Hearne Michael S | Chief Financial Officer | Oct 15, 2020 | Option Exercise | $3.32 | 169 | 561 | 169 | Oct 19, 2020, 09:14 PM |
| Chawla Lakhmir S | Chief Medical Officer | Sep 15, 2020 | Option Exercise | $3.85 | 286 | 1,101 | 13,447 | Sep 17, 2020, 04:57 PM |
| RAMSAY DAVID A | Director | Sep 08, 2020 | Buy | $3.83 | 1,000 | 3,830 | 48,000 | Sep 10, 2020, 04:02 PM |
| TANG KEVIN C | Director | Sep 09, 2020 | Buy | $4.03 | 126,665 | 509,940 | 9,405,490 | Sep 09, 2020, 06:55 PM |
| TANG KEVIN C | Director | Sep 08, 2020 | Buy | $3.90 | 84,152 | 328,529 | 9,278,825 | Sep 09, 2020, 06:55 PM |
| TANG KEVIN C | Director | Sep 04, 2020 | Buy | $3.82 | 67,552 | 258,359 | 9,194,673 | Sep 09, 2020, 06:55 PM |
| Chawla Lakhmir S | Chief Medical Officer | Aug 31, 2020 | Option Exercise | $3.57 | 550 | 1,963 | 13,161 | Sep 02, 2020, 04:17 PM |
| RAMSAY DAVID A | Director | Aug 21, 2020 | Buy | $3.97 | 28,000 | 111,108 | 40,000 | Aug 24, 2020, 04:22 PM |
| RAMSAY DAVID A | Director | Aug 20, 2020 | Buy | $4.17 | 12,000 | 50,060 | 12,000 | Aug 24, 2020, 04:22 PM |
| RAMSAY DAVID A | Director | Aug 24, 2020 | Buy | $3.76 | 7,000 | 26,289 | 47,000 | Aug 24, 2020, 04:22 PM |
| Chawla Lakhmir S | Chief Medical Officer | Aug 14, 2020 | Option Exercise | $3.34 | 589 | 1,967 | 12,611 | Aug 18, 2020, 05:18 PM |
| TANG KEVIN C | Director | Aug 14, 2020 | Buy | $3.88 | 168,669 | 653,694 | 9,127,121 | Aug 14, 2020, 04:49 PM |
| TANG KEVIN C | Director | Aug 13, 2020 | Buy | $3.65 | 219,465 | 800,586 | 8,958,452 | Aug 14, 2020, 04:49 PM |
| TANG KEVIN C | Director | Aug 12, 2020 | Buy | $3.47 | 43,513 | 150,820 | 8,738,987 | Aug 14, 2020, 04:49 PM |
| Chawla Lakhmir S | Chief Medical Officer | Jul 31, 2020 | Option Exercise | $3.38 | 581 | 1,964 | 12,022 | Aug 04, 2020, 05:24 PM |
| Chawla Lakhmir S | Chief Medical Officer | Jul 15, 2020 | Option Exercise | $3.77 | 521 | 1,964 | 11,441 | Jul 17, 2020, 04:05 PM |
| Chawla Lakhmir S | Chief Medical Officer | Jun 30, 2020 | Option Exercise | $3.62 | 543 | 1,966 | 10,920 | Jul 01, 2020, 07:08 PM |
| Chawla Lakhmir S | Chief Medical Officer | Jun 15, 2020 | Option Exercise | $4.51 | 435 | 1,962 | 10,377 | Jun 17, 2020, 06:26 PM |
| TANG KEVIN C | Director | Jun 04, 2020 | Buy | $4.94 | 215,812 | 1,065,636 | 8,695,474 | Jun 04, 2020, 06:26 PM |
| TANG KEVIN C | Director | Jun 03, 2020 | Buy | $4.90 | 145,764 | 714,783 | 8,479,662 | Jun 04, 2020, 06:26 PM |
| TANG KEVIN C | Director | Jun 02, 2020 | Buy | $4.88 | 253,553 | 1,237,060 | 8,333,898 | Jun 04, 2020, 06:26 PM |
| MULROY DENNIS | Chief Financial Officer | May 29, 2020 | Option Exercise | $4.01 | 82 | 329 | 5,067 | Jun 02, 2020, 04:03 PM |
| Chawla Lakhmir S | Chief Medical Officer | May 29, 2020 | Option Exercise | $4.01 | 491 | 1,969 | 9,942 | Jun 02, 2020, 04:02 PM |
| Rolke James | Chief Scientific Officer | May 29, 2020 | Option Exercise | $4.01 | 205 | 822 | 81,771 | Jun 02, 2020, 04:02 PM |
| MULROY DENNIS | Chief Financial Officer | May 15, 2020 | Option Exercise | $5.86 | 56 | 328 | 4,985 | May 19, 2020, 04:05 PM |
| Chawla Lakhmir S | Chief Medical Officer | May 15, 2020 | Option Exercise | $5.86 | 335 | 1,963 | 9,451 | May 19, 2020, 04:05 PM |
| Rolke James | Chief Scientific Officer | May 15, 2020 | Option Exercise | $5.86 | 140 | 820 | 81,566 | May 19, 2020, 04:05 PM |
| Rolke James | Chief Scientific Officer | Apr 30, 2020 | Option Exercise | $6.17 | 133 | 821 | 81,426 | May 04, 2020, 04:09 PM |
| Chawla Lakhmir S | Chief Medical Officer | Apr 30, 2020 | Option Exercise | $6.17 | 319 | 1,968 | 9,116 | May 04, 2020, 04:09 PM |
| MULROY DENNIS | Chief Financial Officer | Apr 30, 2020 | Option Exercise | $6.17 | 53 | 327 | 4,929 | May 04, 2020, 04:08 PM |
| MULROY DENNIS | Chief Financial Officer | Apr 15, 2020 | Option Exercise | $5.61 | 58 | 325 | 4,876 | Apr 17, 2020, 04:03 PM |
| Wellinghoff Darryl | Chief Commercial Officer | Apr 15, 2020 | Option Exercise | $5.61 | 34 | 191 | 9,504 | Apr 17, 2020, 04:03 PM |
| Chawla Lakhmir S | Chief Medical Officer | Apr 15, 2020 | Option Exercise | $5.61 | 350 | 1,964 | 8,797 | Apr 17, 2020, 04:02 PM |
| Rolke James | Chief Scientific Officer | Apr 15, 2020 | Option Exercise | $5.61 | 146 | 819 | 81,293 | Apr 17, 2020, 04:02 PM |
| Chawla Lakhmir S | Chief Medical Officer | Mar 31, 2020 | Option Exercise | $3.57 | 165 | 589 | 8,447 | Apr 02, 2020, 06:08 PM |
| Wellinghoff Darryl | Chief Commercial Officer | Mar 31, 2020 | Option Exercise | $3.57 | 459 | 1,639 | 9,470 | Apr 02, 2020, 06:08 PM |
| Rolke James | Chief Scientific Officer | Mar 31, 2020 | Option Exercise | $3.57 | 229 | 818 | 81,147 | Apr 02, 2020, 06:08 PM |
| Rolke James | Chief Scientific Officer | Mar 13, 2020 | Option Exercise | $3.40 | 241 | 819 | 80,918 | Mar 16, 2020, 04:13 PM |
| Wellinghoff Darryl | Chief Commercial Officer | Mar 13, 2020 | Option Exercise | $3.40 | 483 | 1,642 | 9,011 | Mar 16, 2020, 04:13 PM |
| Chawla Lakhmir S | Chief Medical Officer | Mar 13, 2020 | Option Exercise | $3.40 | 173 | 588 | 8,282 | Mar 16, 2020, 04:12 PM |
| Rolke James | Chief Scientific Officer | Feb 28, 2020 | Option Exercise | $5.78 | 142 | 821 | 80,677 | Mar 03, 2020, 04:14 PM |
| Chawla Lakhmir S | Chief Medical Officer | Feb 28, 2020 | Option Exercise | $5.78 | 102 | 590 | 8,109 | Mar 03, 2020, 04:14 PM |
| Wellinghoff Darryl | Chief Commercial Officer | Feb 28, 2020 | Option Exercise | $5.78 | 284 | 1,642 | 8,528 | Mar 03, 2020, 04:13 PM |
| Wellinghoff Darryl | Chief Commercial Officer | Feb 14, 2020 | Option Exercise | $7.14 | 229 | 1,635 | 8,244 | Feb 19, 2020, 04:48 PM |
| Chawla Lakhmir S | Chief Medical Officer | Feb 14, 2020 | Option Exercise | $7.14 | 83 | 593 | 8,007 | Feb 19, 2020, 04:48 PM |
| Rolke James | Chief Scientific Officer | Feb 14, 2020 | Option Exercise | $7.14 | 115 | 821 | 80,535 | Feb 19, 2020, 04:47 PM |
| Chawla Lakhmir S | Chief Medical Officer | Jan 31, 2020 | Option Exercise | $5.82 | 101 | 588 | 7,924 | Feb 04, 2020, 04:02 PM |
| Rolke James | Chief Scientific Officer | Jan 31, 2020 | Option Exercise | $5.82 | 141 | 821 | 80,420 | Feb 04, 2020, 04:01 PM |
| Wellinghoff Darryl | Chief Commercial Officer | Jan 31, 2020 | Option Exercise | $5.82 | 282 | 1,641 | 8,015 | Feb 04, 2020, 12:00 AM |
| TANG KEVIN C | Director | Feb 03, 2020 | Buy | $6.80 | 75,003 | 509,833 | 8,080,345 | Feb 03, 2020, 05:02 PM |
| TANG KEVIN C | Director | Jan 31, 2020 | Buy | $6.75 | 13,292 | 89,705 | 8,005,342 | Feb 03, 2020, 05:02 PM |
| TANG KEVIN C | Director | Jan 30, 2020 | Buy | $6.72 | 81,475 | 547,431 | 7,992,050 | Feb 03, 2020, 05:02 PM |
| Wellinghoff Darryl | Chief Commercial Officer | Jan 15, 2020 | Option Exercise | $6.70 | 1,188 | 7,960 | 7,733 | Jan 17, 2020, 04:14 PM |
| Chawla Lakhmir S | Chief Medical Officer | Jan 15, 2020 | Option Exercise | $6.70 | 498 | 3,337 | 7,823 | Jan 17, 2020, 04:14 PM |
| Rolke James | Chief Scientific Officer | Jan 15, 2020 | Option Exercise | $6.70 | 692 | 4,636 | 80,279 | Jan 17, 2020, 04:13 PM |
| Wellinghoff Darryl | Chief Commercial Officer | Jan 14, 2020 | Buy | $8.23 | 3,000 | 24,677 | 6,545 | Jan 16, 2020, 04:05 PM |
| TANG KEVIN C | Director | Jan 13, 2020 | Buy | $6.66 | 1,253,878 | 8,351,580 | 7,910,575 | Jan 13, 2020, 05:59 PM |
| TANG KEVIN C | Director | Jan 10, 2020 | Buy | $5.70 | 717,804 | 4,090,909 | 6,656,697 | Jan 13, 2020, 05:59 PM |
| TANG KEVIN C | Director | Jan 09, 2020 | Buy | $4.99 | 1,000,000 | 4,991,980 | 5,938,893 | Jan 13, 2020, 05:59 PM |
| Chawla Lakhmir S | Chief Medical Officer | Dec 31, 2019 | Option Exercise | $3.34 | 172 | 574 | 7,325 | Jan 03, 2020, 04:34 PM |
| MULROY DENNIS | Chief Financial Officer | Dec 31, 2019 | Option Exercise | $3.34 | 16 | 53 | 4,818 | Jan 03, 2020, 12:00 AM |
| MULROY DENNIS | Chief Financial Officer | Dec 13, 2019 | Option Exercise | $2.85 | 112 | 319 | 4,802 | Dec 17, 2019, 04:03 PM |
| Chawla Lakhmir S | Chief Medical Officer | Dec 13, 2019 | Option Exercise | $2.85 | 201 | 573 | 7,153 | Dec 17, 2019, 04:03 PM |
| Chawla Lakhmir S | Chief Medical Officer | Nov 29, 2019 | Option Exercise | $2.33 | 247 | 576 | 6,952 | Dec 03, 2019, 04:28 PM |
| MULROY DENNIS | Chief Financial Officer | Nov 29, 2019 | Option Exercise | $2.33 | 138 | 322 | 4,690 | Dec 03, 2019, 04:27 PM |
| Wellinghoff Darryl | Chief Commercial Officer | Nov 29, 2019 | Option Exercise | $2.33 | 17 | 40 | 3,545 | Dec 03, 2019, 04:27 PM |
| Rolke James | Chief Scientific Officer | Nov 15, 2019 | Option Exercise | $5.12 | 118 | 604 | 79,587 | Nov 19, 2019, 04:12 PM |
| Wellinghoff Darryl | Chief Commercial Officer | Nov 15, 2019 | Option Exercise | $5.12 | 311 | 1,592 | 3,528 | Nov 19, 2019, 04:12 PM |
| MULROY DENNIS | Chief Financial Officer | Nov 15, 2019 | Option Exercise | $5.12 | 62 | 317 | 4,552 | Nov 19, 2019, 04:11 PM |
| Chawla Lakhmir S | Chief Medical Officer | Nov 15, 2019 | Option Exercise | $5.12 | 111 | 568 | 6,705 | Nov 19, 2019, 04:11 PM |
| Rolke James | Chief Scientific Officer | Oct 31, 2019 | Option Exercise | $5.96 | 133 | 793 | 79,469 | Nov 05, 2019, 04:06 PM |
| Wellinghoff Darryl | Chief Commercial Officer | Oct 31, 2019 | Option Exercise | $5.96 | 267 | 1,591 | 3,217 | Nov 05, 2019, 04:05 PM |
| Chawla Lakhmir S | Chief Medical Officer | Oct 31, 2019 | Option Exercise | $5.96 | 96 | 572 | 6,594 | Nov 05, 2019, 04:05 PM |
| MULROY DENNIS | Chief Financial Officer | Oct 31, 2019 | Option Exercise | $5.96 | 267 | 1,591 | 4,490 | Nov 05, 2019, 04:04 PM |
| Wellinghoff Darryl | Chief Commercial Officer | Oct 15, 2019 | Option Exercise | $7.12 | 224 | 1,595 | 2,950 | Oct 17, 2019, 05:42 PM |
| Chawla Lakhmir S | Chief Medical Officer | Oct 15, 2019 | Option Exercise | $7.12 | 81 | 577 | 6,498 | Oct 17, 2019, 05:41 PM |
| MULROY DENNIS | Chief Financial Officer | Oct 15, 2019 | Option Exercise | $7.12 | 224 | 1,595 | 4,223 | Oct 17, 2019, 05:41 PM |
| Rolke James | Chief Scientific Officer | Oct 15, 2019 | Option Exercise | $7.12 | 112 | 797 | 79,336 | Oct 17, 2019, 05:40 PM |
| Rolke James | Chief Scientific Officer | Sep 30, 2019 | Option Exercise | $7.48 | 107 | 800 | 79,224 | Oct 02, 2019, 05:06 PM |
| MULROY DENNIS | Chief Financial Officer | Sep 30, 2019 | Option Exercise | $7.48 | 213 | 1,593 | 3,999 | Oct 02, 2019, 05:05 PM |
| Chawla Lakhmir S | Chief Medical Officer | Sep 30, 2019 | Option Exercise | $7.48 | 76 | 568 | 6,417 | Oct 02, 2019, 05:05 PM |
| Wellinghoff Darryl | Chief Commercial Officer | Sep 30, 2019 | Option Exercise | $7.48 | 213 | 1,593 | 2,726 | Oct 02, 2019, 05:04 PM |
| Rolke James | Chief Scientific Officer | Sep 13, 2019 | Option Exercise | $9.28 | 85 | 789 | 79,117 | Sep 16, 2019, 07:24 PM |
| MULROY DENNIS | Chief Financial Officer | Sep 13, 2019 | Option Exercise | $9.28 | 171 | 1,587 | 3,786 | Sep 16, 2019, 07:24 PM |
| Wellinghoff Darryl | Chief Commercial Officer | Sep 13, 2019 | Option Exercise | $9.28 | 171 | 1,587 | 2,513 | Sep 16, 2019, 07:24 PM |
| Chawla Lakhmir S | Chief Medical Officer | Sep 13, 2019 | Option Exercise | $9.28 | 62 | 575 | 6,341 | Sep 16, 2019, 07:23 PM |
| MULROY DENNIS | Chief Financial Officer | Aug 30, 2019 | Option Exercise | $8.13 | 196 | 1,593 | 3,615 | Sep 03, 2019, 04:13 PM |
| Wellinghoff Darryl | Chief Commercial Officer | Aug 30, 2019 | Option Exercise | $8.13 | 196 | 1,593 | 2,342 | Sep 03, 2019, 04:12 PM |
| Chawla Lakhmir S | Chief Medical Officer | Aug 30, 2019 | Option Exercise | $8.13 | 70 | 569 | 6,279 | Sep 03, 2019, 04:12 PM |
| Rolke James | Chief Scientific Officer | Aug 30, 2019 | Option Exercise | $8.13 | 98 | 797 | 79,032 | Sep 03, 2019, 04:12 PM |
| Rolke James | Chief Scientific Officer | Aug 15, 2019 | Option Exercise | $8.02 | 99 | 794 | 78,934 | Aug 16, 2019, 04:51 PM |
| Chawla Lakhmir S | Chief Medical Officer | Aug 15, 2019 | Option Exercise | $8.02 | 72 | 577 | 6,209 | Aug 16, 2019, 04:51 PM |
| MULROY DENNIS | Chief Financial Officer | Aug 15, 2019 | Option Exercise | $8.02 | 198 | 1,588 | 3,419 | Aug 16, 2019, 04:50 PM |
| Wellinghoff Darryl | Chief Commercial Officer | Aug 15, 2019 | Option Exercise | $8.02 | 198 | 1,588 | 2,146 | Aug 16, 2019, 04:50 PM |
| MULROY DENNIS | Chief Financial Officer | Jul 31, 2019 | Option Exercise | $7.11 | 224 | 1,593 | 3,221 | Aug 02, 2019, 04:59 PM |
| Chawla Lakhmir S | Chief Medical Officer | Jul 31, 2019 | Option Exercise | $7.11 | 80 | 569 | 6,137 | Aug 02, 2019, 04:59 PM |
| Wellinghoff Darryl | Chief Commercial Officer | Jul 31, 2019 | Option Exercise | $7.11 | 224 | 1,593 | 1,948 | Aug 02, 2019, 04:59 PM |
| Rolke James | Chief Scientific Officer | Jul 31, 2019 | Option Exercise | $7.11 | 112 | 796 | 78,835 | Aug 02, 2019, 04:59 PM |
| MULROY DENNIS | Chief Financial Officer | Jul 15, 2019 | Option Exercise | $7.85 | 203 | 1,594 | 2,997 | Jul 17, 2019, 05:11 PM |
| Wellinghoff Darryl | Chief Commercial Officer | Jul 15, 2019 | Option Exercise | $7.85 | 203 | 1,594 | 1,724 | Jul 17, 2019, 05:10 PM |
| Rolke James | Chief Scientific Officer | Jul 15, 2019 | Option Exercise | $7.85 | 102 | 801 | 78,723 | Jul 17, 2019, 05:10 PM |
| Chawla Lakhmir S | Chief Medical Officer | Jul 15, 2019 | Option Exercise | $7.85 | 73 | 573 | 6,057 | Jul 17, 2019, 05:10 PM |
| MULROY DENNIS | Chief Financial Officer | Jun 28, 2019 | Option Exercise | $7.86 | 202 | 1,588 | 2,794 | Jul 01, 2019, 06:12 PM |
| Rolke James | Chief Scientific Officer | Jun 28, 2019 | Option Exercise | $7.86 | 101 | 794 | 78,621 | Jul 01, 2019, 06:11 PM |
| Wellinghoff Darryl | Chief Commercial Officer | Jun 28, 2019 | Option Exercise | $7.86 | 202 | 1,588 | 1,521 | Jul 01, 2019, 06:11 PM |
| Chawla Lakhmir S | Chief Medical Officer | Jun 28, 2019 | Option Exercise | $7.86 | 73 | 574 | 5,984 | Jul 01, 2019, 06:11 PM |
| Wellinghoff Darryl | Chief Commercial Officer | Jun 14, 2019 | Option Exercise | $8.25 | 193 | 1,592 | 1,319 | Jun 18, 2019, 04:45 PM |
| MULROY DENNIS | Chief Financial Officer | Jun 14, 2019 | Option Exercise | $8.25 | 193 | 1,592 | 2,592 | Jun 18, 2019, 04:44 PM |
| Rolke James | Chief Scientific Officer | Jun 14, 2019 | Option Exercise | $8.25 | 96 | 792 | 78,520 | Jun 18, 2019, 04:44 PM |
| Chawla Lakhmir S | Chief Medical Officer | Jun 14, 2019 | Option Exercise | $8.25 | 69 | 569 | 5,911 | Jun 18, 2019, 04:44 PM |
| Chawla Lakhmir S | Chief Medical Officer | May 31, 2019 | Option Exercise | $4.58 | 126 | 577 | 5,842 | Jun 03, 2019, 07:27 PM |
| Rolke James | Chief Scientific Officer | May 31, 2019 | Option Exercise | $4.58 | 174 | 797 | 78,424 | Jun 03, 2019, 07:27 PM |
| Wellinghoff Darryl | Chief Commercial Officer | May 31, 2019 | Option Exercise | $4.58 | 347 | 1,589 | 1,126 | Jun 03, 2019, 07:26 PM |
| MULROY DENNIS | Chief Financial Officer | May 31, 2019 | Option Exercise | $4.58 | 347 | 1,589 | 2,399 | Jun 03, 2019, 07:26 PM |
| Rolke James | Chief Scientific Officer | May 15, 2019 | Option Exercise | $5.58 | 143 | 798 | 78,250 | May 17, 2019, 04:07 PM |
| Wellinghoff Darryl | Chief Commercial Officer | May 15, 2019 | Option Exercise | $5.58 | 285 | 1,590 | 779 | May 17, 2019, 04:07 PM |
| Chawla Lakhmir S | Chief Medical Officer | May 15, 2019 | Option Exercise | $5.58 | 102 | 569 | 5,716 | May 17, 2019, 04:06 PM |
| MULROY DENNIS | Chief Financial Officer | May 15, 2019 | Option Exercise | $5.58 | 285 | 1,590 | 2,052 | May 17, 2019, 04:06 PM |
| MULROY DENNIS | Chief Financial Officer | Apr 30, 2019 | Option Exercise | $6.84 | 233 | 1,594 | 1,767 | May 02, 2019, 05:12 PM |
| Rolke James | Chief Scientific Officer | Apr 30, 2019 | Option Exercise | $6.84 | 116 | 793 | 78,107 | May 02, 2019, 05:11 PM |
| Chawla Lakhmir S | Chief Medical Officer | Apr 30, 2019 | Option Exercise | $6.84 | 84 | 575 | 5,614 | May 02, 2019, 05:11 PM |
| Wellinghoff Darryl | Chief Commercial Officer | Apr 30, 2019 | Option Exercise | $6.84 | 233 | 1,594 | 494 | May 02, 2019, 05:10 PM |
| Chawla Lakhmir S | Chief Medical Officer | Apr 15, 2019 | Option Exercise | $6.09 | 94 | 572 | 5,530 | Apr 17, 2019, 05:05 PM |
| Wellinghoff Darryl | Chief Commercial Officer | Apr 15, 2019 | Option Exercise | $6.09 | 261 | 1,589 | 261 | Apr 17, 2019, 05:05 PM |
| TIDMARSH GEORGE F | President, CEO & Secretary | Apr 15, 2019 | Option Exercise | $6.09 | 2 | 12 | 1,263,895 | Apr 17, 2019, 05:04 PM |
| MULROY DENNIS | Chief Financial Officer | Apr 15, 2019 | Option Exercise | $6.09 | 261 | 1,589 | 1,534 | Apr 17, 2019, 05:02 PM |
| Rolke James | Chief Scientific Officer | Apr 15, 2019 | Option Exercise | $6.09 | 131 | 798 | 77,991 | Apr 17, 2019, 05:01 PM |
| Rolke James | Chief Scientific Officer | Mar 29, 2019 | Option Exercise | $5.47 | 146 | 799 | 77,860 | Apr 02, 2019, 07:08 PM |
| MULROY DENNIS | Chief Financial Officer | Mar 29, 2019 | Option Exercise | $5.47 | 59 | 323 | 1,273 | Apr 02, 2019, 07:07 PM |
| TIDMARSH GEORGE F | President, CEO & Secretary | Mar 29, 2019 | Option Exercise | $5.47 | 94 | 514 | 1,263,893 | Apr 02, 2019, 07:07 PM |
| Chawla Lakhmir S | Chief Medical Officer | Mar 29, 2019 | Option Exercise | $5.47 | 35 | 191 | 5,436 | Apr 02, 2019, 07:06 PM |
| TIDMARSH GEORGE F | President, CEO & Secretary | Mar 15, 2019 | Option Exercise | $6.49 | 195 | 1,266 | 1,263,799 | Mar 19, 2019, 05:08 PM |
| Rolke James | Chief Scientific Officer | Mar 15, 2019 | Option Exercise | $6.49 | 122 | 792 | 77,714 | Mar 19, 2019, 05:07 PM |
| Chawla Lakhmir S | Chief Medical Officer | Mar 15, 2019 | Option Exercise | $6.49 | 29 | 188 | 5,401 | Mar 19, 2019, 05:06 PM |
| MULROY DENNIS | Chief Financial Officer | Mar 15, 2019 | Option Exercise | $6.49 | 49 | 318 | 1,214 | Mar 19, 2019, 04:49 PM |
| TIDMARSH GEORGE F | President, CEO & Secretary | Feb 28, 2019 | Option Exercise | $4.85 | 261 | 1,266 | 1,263,604 | Mar 04, 2019, 05:33 PM |
| Rolke James | Chief Scientific Officer | Feb 28, 2019 | Option Exercise | $4.85 | 164 | 795 | 77,592 | Mar 04, 2019, 05:32 PM |
| MULROY DENNIS | Chief Financial Officer | Feb 28, 2019 | Option Exercise | $4.85 | 65 | 315 | 1,165 | Mar 04, 2019, 05:32 PM |
| Chawla Lakhmir S | Chief Medical Officer | Feb 28, 2019 | Option Exercise | $4.85 | 40 | 194 | 5,372 | Mar 04, 2019, 05:31 PM |
| CARVER JENNIFER | Chief Operating Officer | Feb 28, 2019 | Option Exercise | $4.85 | 230 | 1,115 | 14,049 | Mar 04, 2019, 05:30 PM |
| Chawla Lakhmir S | Chief Medical Officer | Feb 15, 2019 | Option Exercise | $5.30 | 36 | 191 | 5,332 | Feb 19, 2019, 06:12 PM |
| MULROY DENNIS | Chief Financial Officer | Feb 15, 2019 | Option Exercise | $5.30 | 60 | 318 | 1,100 | Feb 19, 2019, 06:11 PM |
| CARVER JENNIFER | Chief Operating Officer | Feb 15, 2019 | Option Exercise | $5.30 | 230 | 1,219 | 13,819 | Feb 19, 2019, 06:11 PM |
| TIDMARSH GEORGE F | President, CEO & Secretary | Feb 15, 2019 | Option Exercise | $5.30 | 239 | 1,267 | 1,263,343 | Feb 19, 2019, 06:10 PM |
| Rolke James | Chief Scientific Officer | Feb 15, 2019 | Option Exercise | $5.30 | 151 | 800 | 77,428 | Feb 19, 2019, 06:10 PM |
| CARVER JENNIFER | Chief Operating Officer | Jan 31, 2019 | Option Exercise | $5.13 | 1,260 | 6,464 | 13,589 | Feb 04, 2019, 06:14 PM |
| TIDMARSH GEORGE F | President, CEO & Secretary | Jan 31, 2019 | Option Exercise | $5.13 | 246 | 1,262 | 1,284,446 | Feb 04, 2019, 06:13 PM |
| MULROY DENNIS | Chief Financial Officer | Jan 31, 2019 | Option Exercise | $5.13 | 63 | 323 | 1,040 | Feb 04, 2019, 06:13 PM |
| Rolke James | Chief Scientific Officer | Jan 31, 2019 | Option Exercise | $5.13 | 155 | 795 | 77,277 | Feb 04, 2019, 06:12 PM |
| Chawla Lakhmir S | Chief Medical Officer | Jan 31, 2019 | Option Exercise | $5.13 | 37 | 190 | 5,296 | Feb 04, 2019, 06:12 PM |
| Chawla Lakhmir S | Chief Medical Officer | Jan 29, 2019 | Buy | $5.56 | 2,000 | 11,124 | 4,259 | Jan 31, 2019, 06:49 PM |
| Chawla Lakhmir S | Chief Medical Officer | Jan 30, 2019 | Buy | $5.57 | 1,000 | 5,570 | 5,259 | Jan 31, 2019, 06:49 PM |
| CARVER JENNIFER | Chief Operating Officer | Jan 15, 2019 | Option Exercise | $5.74 | 213 | 1,223 | 12,329 | Jan 17, 2019, 08:54 PM |
| MULROY DENNIS | Chief Financial Officer | Jan 15, 2019 | Option Exercise | $5.74 | 316 | 1,814 | 977 | Jan 17, 2019, 08:54 PM |
| Chawla Lakhmir S | Chief Medical Officer | Jan 15, 2019 | Option Exercise | $5.74 | 72 | 413 | 2,259 | Jan 17, 2019, 08:53 PM |
| Rolke James | Chief Scientific Officer | Jan 15, 2019 | Option Exercise | $5.74 | 792 | 4,546 | 77,122 | Jan 17, 2019, 08:52 PM |
| TIDMARSH GEORGE F | President, CEO & Secretary | Jan 15, 2019 | Option Exercise | $5.74 | 874 | 5,017 | 1,284,200 | Jan 17, 2019, 08:52 PM |
| TANG KEVIN C | Director | Jan 08, 2019 | Buy | $5.32 | 1,120,786 | 5,962,639 | 4,859,679 | Jan 09, 2019, 09:54 PM |
| TANG KEVIN C | Director | Jan 07, 2019 | Buy | $5.84 | 100,000 | 583,840 | 3,738,893 | Jan 09, 2019, 09:54 PM |
| TANG KEVIN C | Director | Jan 09, 2019 | Buy | $5.54 | 79,214 | 438,806 | 4,938,893 | Jan 09, 2019, 09:54 PM |
| TIDMARSH GEORGE F | President, CEO & Secretary | Jan 07, 2019 | Buy | $5.85 | 2,000 | 11,700 | 1,283,326 | Jan 09, 2019, 09:29 PM |
| CARVER JENNIFER | Chief Operating Officer | Jan 09, 2019 | Buy | $6.17 | 5,000 | 30,825 | 12,116 | Jan 09, 2019, 09:29 PM |
| Rolke James | Chief Scientific Officer | Jan 09, 2019 | Buy | $6.09 | 1,600 | 9,746 | 76,330 | Jan 09, 2019, 09:28 PM |
| PERCEPTIVE ADVISORS LLC | 10% Owner | Jan 07, 2019 | Sale | $6.36 | 810,000 | 5,147,749 | 3,881,967 | Jan 09, 2019, 07:37 PM |
| PERCEPTIVE ADVISORS LLC | 10% Owner | Jan 08, 2019 | Sale | $5.25 | 1,250,235 | 6,568,236 | 2,703,611 | Jan 09, 2019, 07:37 PM |
| Chawla Lakhmir S | Chief Medical Officer | Dec 31, 2018 | Option Exercise | $8.02 | 23 | 184 | 2,187 | Jan 03, 2019, 07:53 PM |
| Rolke James | Chief Scientific Officer | Dec 31, 2018 | Option Exercise | $8.02 | 97 | 778 | 74,730 | Jan 03, 2019, 07:53 PM |
| MULROY DENNIS | Chief Financial Officer | Dec 31, 2018 | Option Exercise | $8.02 | 39 | 313 | 661 | Jan 03, 2019, 07:52 PM |
| TIDMARSH GEORGE F | President, CEO & Secretary | Dec 31, 2018 | Option Exercise | $8.02 | 154 | 1,234 | 1,281,326 | Jan 03, 2019, 07:51 PM |
| CARVER JENNIFER | Chief Operating Officer | Dec 31, 2018 | Option Exercise | $8.02 | 148 | 1,186 | 7,116 | Jan 03, 2019, 07:51 PM |
| Chawla Lakhmir S | Chief Medical Officer | Dec 14, 2018 | Option Exercise | $10.88 | 17 | 185 | 2,164 | Dec 17, 2018, 08:30 PM |
| MULROY DENNIS | Chief Financial Officer | Dec 14, 2018 | Option Exercise | $10.88 | 28 | 305 | 622 | Dec 17, 2018, 08:29 PM |
| TIDMARSH GEORGE F | President, CEO & Secretary | Dec 14, 2018 | Option Exercise | $10.88 | 112 | 1,219 | 1,281,172 | Dec 17, 2018, 08:28 PM |
| Rolke James | Chief Scientific Officer | Dec 14, 2018 | Option Exercise | $10.88 | 70 | 762 | 74,633 | Dec 17, 2018, 08:28 PM |
| CARVER JENNIFER | Chief Operating Officer | Dec 14, 2018 | Option Exercise | $10.88 | 108 | 1,175 | 6,968 | Dec 17, 2018, 08:27 PM |
| MULROY DENNIS | Chief Financial Officer | Nov 30, 2018 | Option Exercise | $12.30 | 26 | 320 | 594 | Dec 03, 2018, 09:57 PM |
| Rolke James | Chief Scientific Officer | Nov 30, 2018 | Option Exercise | $12.30 | 63 | 775 | 74,563 | Dec 03, 2018, 09:56 PM |
| TIDMARSH GEORGE F | President, CEO & Secretary | Nov 30, 2018 | Option Exercise | $12.30 | 100 | 1,230 | 1,281,060 | Dec 03, 2018, 09:56 PM |
| Chawla Lakhmir S | Chief Medical Officer | Nov 30, 2018 | Option Exercise | $12.30 | 16 | 197 | 2,147 | Dec 03, 2018, 09:56 PM |
| CARVER JENNIFER | Chief Operating Officer | Nov 30, 2018 | Option Exercise | $12.30 | 96 | 1,181 | 6,860 | Dec 03, 2018, 09:55 PM |
| TIDMARSH GEORGE F | President, CEO & Secretary | Nov 15, 2018 | Option Exercise | $12.66 | 97 | 1,229 | 1,280,960 | Nov 19, 2018, 05:06 PM |
| Rolke James | Chief Scientific Officer | Nov 15, 2018 | Option Exercise | $12.66 | 61 | 773 | 74,500 | Nov 19, 2018, 05:06 PM |
| MULROY DENNIS | Chief Financial Officer | Nov 15, 2018 | Option Exercise | $12.66 | 24 | 304 | 568 | Nov 19, 2018, 05:05 PM |
| CARVER JENNIFER | Chief Operating Officer | Nov 15, 2018 | Option Exercise | $12.66 | 94 | 1,191 | 6,764 | Nov 19, 2018, 05:05 PM |
| Chawla Lakhmir S | Chief Medical Officer | Nov 15, 2018 | Option Exercise | $12.66 | 16 | 203 | 2,131 | Nov 19, 2018, 05:04 PM |
| Rolke James | Chief Scientific Officer | Oct 31, 2018 | Option Exercise | $13.85 | 56 | 776 | 74,439 | Nov 01, 2018, 08:43 PM |
| CARVER JENNIFER | Chief Operating Officer | Oct 31, 2018 | Option Exercise | $13.85 | 85 | 1,178 | 6,670 | Nov 01, 2018, 08:42 PM |
| Chawla Lakhmir S | Chief Medical Officer | Oct 31, 2018 | Option Exercise | $13.85 | 15 | 208 | 2,115 | Nov 01, 2018, 08:42 PM |
| TIDMARSH GEORGE F | President, CEO & Secretary | Oct 31, 2018 | Option Exercise | $13.85 | 89 | 1,233 | 1,280,863 | Nov 01, 2018, 08:41 PM |
| MULROY DENNIS | Chief Financial Officer | Oct 31, 2018 | Option Exercise | $13.85 | 22 | 305 | 544 | Nov 01, 2018, 08:40 PM |
| MULROY DENNIS | Chief Financial Officer | Oct 15, 2018 | Option Exercise | $13.81 | 22 | 304 | 522 | Oct 15, 2018, 08:53 PM |
| Chawla Lakhmir S | Chief Medical Officer | Oct 15, 2018 | Option Exercise | $13.81 | 15 | 207 | 2,100 | Oct 15, 2018, 08:53 PM |
| Rolke James | Chief Scientific Officer | Oct 15, 2018 | Option Exercise | $13.81 | 55 | 760 | 74,383 | Oct 15, 2018, 08:52 PM |
| TIDMARSH GEORGE F | President, CEO & Secretary | Oct 15, 2018 | Option Exercise | $13.81 | 88 | 1,215 | 1,280,774 | Oct 15, 2018, 08:52 PM |
| CARVER JENNIFER | Chief Operating Officer | Oct 15, 2018 | Option Exercise | $13.81 | 85 | 1,174 | 6,585 | Oct 15, 2018, 08:51 PM |
| Rolke James | Chief Scientific Officer | Aug 16, 2018 | Buy | $22.00 | 1,000 | 21,997 | 74,328 | Aug 20, 2018, 09:06 PM |
| CARVER JENNIFER | Chief Operating Officer | Aug 16, 2018 | Buy | $20.90 | 1,000 | 20,895 | 6,500 | Aug 20, 2018, 09:05 PM |
| Douglass Laura L. | Director | May 30, 2018 | Option Exercise | $6.00 | 500 | 3,000 | 500 | Jun 01, 2018, 09:12 PM |
| PERCEPTIVE ADVISORS LLC | 10% Owner | Mar 15, 2018 | Buy | $29.50 | 700,000 | 20,650,000 | 4,313,611 | Mar 26, 2018, 04:59 PM |
| TANG KEVIN C | Director | Mar 15, 2018 | Buy | $29.50 | 508,474 | 14,999,983 | 4,138,893 | Mar 19, 2018, 08:15 PM |
| TANG KEVIN C | Director | Mar 02, 2018 | Buy | $30.44 | 10,000 | 304,435 | 3,630,419 | Mar 02, 2018, 05:56 PM |
| TANG KEVIN C | Director | Feb 28, 2018 | Buy | $29.94 | 30,000 | 898,092 | 3,620,419 | Mar 02, 2018, 05:56 PM |
| CARVER JENNIFER | Chief Operating Officer | Feb 23, 2018 | Buy | $32.47 | 1,000 | 32,475 | 5,500 | Feb 27, 2018, 09:00 PM |
| TANG KEVIN C | Director | Feb 27, 2018 | Buy | $31.19 | 69,000 | 2,152,164 | 3,590,419 | Feb 27, 2018, 04:50 PM |
| TANG KEVIN C | Director | Feb 26, 2018 | Buy | $32.69 | 21,000 | 686,483 | 3,521,419 | Feb 27, 2018, 04:50 PM |
| TANG KEVIN C | Director | Feb 23, 2018 | Buy | $32.23 | 60,000 | 1,933,687 | 3,500,419 | Feb 27, 2018, 04:50 PM |
| PERCEPTIVE ADVISORS LLC | 10% Owner | Feb 15, 2018 | Buy | $32.42 | 50,000 | 1,621,000 | 3,613,611 | Feb 20, 2018, 04:19 PM |
| PERCEPTIVE ADVISORS LLC | 10% Owner | Feb 14, 2018 | Buy | $32.69 | 100,000 | 3,269,000 | 3,563,611 | Feb 15, 2018, 04:17 PM |
| PERCEPTIVE ADVISORS LLC | 10% Owner | Feb 13, 2018 | Buy | $32.75 | 75,000 | 2,456,250 | 3,463,611 | Feb 15, 2018, 04:17 PM |
| Douglass Laura L. | Director | Dec 29, 2017 | Option Exercise | $8.90 | 10,000 | 89,040 | 10,000 | Jan 03, 2018, 09:55 PM |
| Douglass Laura L. | Director | Dec 29, 2017 | Sale | $32.32 | 10,000 | 323,208 | 0 | Jan 03, 2018, 09:55 PM |
| CARVER JENNIFER | Chief Operating Officer | Dec 27, 2017 | Buy | $33.22 | 1,000 | 33,215 | 4,500 | Dec 29, 2017, 05:07 PM |
| TANG KEVIN C | Director | Mar 23, 2017 | Buy | $33.50 | 149,254 | 5,000,009 | 3,440,419 | Mar 27, 2017, 04:15 PM |
| TIDMARSH GEORGE F | President, CEO & Secretary | Mar 03, 2017 | Buy | $34.15 | 1,000 | 34,150 | 1,354,086 | Mar 06, 2017, 04:02 PM |
| TIDMARSH GEORGE F | President, CEO & Secretary | Mar 02, 2017 | Buy | $34.18 | 2,000 | 68,355 | 1,353,086 | Mar 06, 2017, 04:02 PM |
| CARVER JENNIFER | Chief Operating Officer | Mar 02, 2017 | Buy | $34.46 | 1,000 | 34,460 | 3,500 | Mar 06, 2017, 04:02 PM |
| Chawla Lakhmir S | Chief Medical Officer | Mar 02, 2017 | Buy | $35.33 | 600 | 21,198 | 1,085 | Mar 06, 2017, 04:01 PM |
| Chawla Lakhmir S | Chief Medical Officer | Mar 03, 2017 | Buy | $34.48 | 1,000 | 34,480 | 2,085 | Mar 06, 2017, 04:01 PM |
| TANG KEVIN C | Director | Mar 02, 2017 | Buy | $34.64 | 100,000 | 3,463,840 | 3,291,165 | Mar 06, 2017, 04:01 PM |
| MULROY DENNIS | Chief Financial Officer | Mar 03, 2017 | Buy | $33.95 | 500 | 16,975 | 500 | Mar 06, 2017, 04:01 PM |
| TANG KEVIN C | Director | Sep 09, 2016 | Buy | $19.72 | 100,000 | 1,971,970 | 3,152,130 | Sep 13, 2016, 06:42 PM |
| TANG KEVIN C | Director | Sep 13, 2016 | Buy | $20.28 | 16,448 | 333,514 | 3,191,165 | Sep 13, 2016, 06:42 PM |
| TANG KEVIN C | Director | Sep 12, 2016 | Buy | $19.92 | 22,587 | 449,886 | 3,174,717 | Sep 13, 2016, 06:42 PM |
| TANG KEVIN C | Director | Mar 04, 2016 | Buy | $19.85 | 20,000 | 396,928 | 3,052,130 | Mar 08, 2016, 04:12 PM |
| TIDMARSH GEORGE F | President, CEO & Secretary | Mar 01, 2016 | Buy | $16.57 | 2,000 | 33,140 | 1,425,086 | Mar 03, 2016, 06:22 PM |
| TANG KEVIN C | Director | Mar 03, 2016 | Buy | $18.77 | 73,500 | 1,379,234 | 3,032,130 | Mar 03, 2016, 04:22 PM |
| TANG KEVIN C | Director | Mar 02, 2016 | Buy | $18.19 | 30,528 | 555,439 | 2,958,630 | Mar 03, 2016, 04:22 PM |
| TANG KEVIN C | Director | Mar 01, 2016 | Buy | $16.38 | 55,972 | 916,814 | 2,928,102 | Mar 03, 2016, 04:22 PM |
| Chawla Lakhmir S | Chief Medical Officer | Sep 28, 2015 | Buy | $27.75 | 485 | 13,461 | 485 | Sep 30, 2015, 05:22 PM |
| TANG KEVIN C | Director | Sep 10, 2015 | Buy | $38.00 | 80,000 | 3,040,000 | 2,872,130 | Sep 14, 2015, 04:03 PM |
| TANG KEVIN C | Director | Aug 21, 2015 | Buy | $27.69 | 250,000 | 6,922,575 | 2,792,130 | Aug 21, 2015, 04:14 PM |
| TANG KEVIN C | Director | Aug 20, 2015 | Buy | $26.84 | 250,000 | 6,709,875 | 2,742,130 | Aug 21, 2015, 04:14 PM |
| TANG KEVIN C | Director | Aug 19, 2015 | Buy | $26.90 | 350,000 | 9,413,700 | 2,692,130 | Aug 21, 2015, 04:14 PM |
| TANG KEVIN C | Director | Jun 26, 2015 | Buy | $23.58 | 110,000 | 2,593,470 | 2,622,130 | Jun 30, 2015, 04:01 PM |
| TANG KEVIN C | Director | Jun 24, 2015 | Buy | $22.94 | 88,314 | 2,026,188 | 2,512,130 | Jun 24, 2015, 04:48 PM |
| TANG KEVIN C | Director | Jun 23, 2015 | Buy | $22.27 | 53,836 | 1,198,739 | 2,423,816 | Jun 24, 2015, 04:48 PM |
| TANG KEVIN C | Director | Jun 22, 2015 | Buy | $21.41 | 77,850 | 1,666,597 | 2,369,980 | Jun 24, 2015, 04:48 PM |
| Zarrabian Saiid | Director | May 14, 2015 | Buy | $19.50 | 307 | 5,987 | 688 | May 15, 2015, 04:44 PM |
| TANG KEVIN C | Director | May 13, 2015 | Buy | $18.63 | 47,483 | 884,532 | 2,292,130 | May 13, 2015, 05:02 PM |
| TANG KEVIN C | Director | May 12, 2015 | Buy | $18.25 | 44,400 | 810,362 | 2,244,647 | May 13, 2015, 05:02 PM |
| TANG KEVIN C | Director | May 11, 2015 | Buy | $18.04 | 98,700 | 1,780,548 | 2,200,247 | May 13, 2015, 05:02 PM |
| TIDMARSH GEORGE F | President, CEO & Secretary | May 12, 2015 | Buy | $18.36 | 2,000 | 36,720 | 1,423,086 | May 13, 2015, 04:55 PM |
| TIDMARSH GEORGE F | President, CEO & Secretary | May 12, 2015 | Buy | $18.38 | 2,000 | 36,760 | 22,000 | May 13, 2015, 04:55 PM |
| TANG KEVIN C | Director | Dec 16, 2014 | Buy | $13.95 | 582 | 8,117 | 2,101,547 | Dec 18, 2014, 04:21 PM |
| TANG KEVIN C | Director | Dec 15, 2014 | Buy | $13.93 | 32,343 | 450,574 | 2,100,965 | Dec 15, 2014, 08:23 PM |
| TANG KEVIN C | Director | Dec 12, 2014 | Buy | $13.71 | 77,304 | 1,059,846 | 2,068,622 | Dec 15, 2014, 08:23 PM |
| TANG KEVIN C | Director | Dec 11, 2014 | Buy | $12.01 | 122,696 | 1,473,910 | 1,991,318 | Dec 15, 2014, 08:23 PM |
| TIDMARSH GEORGE F | President, CEO & Secretary | Dec 11, 2014 | Buy | $11.38 | 4,000 | 45,520 | 1,421,086 | Dec 12, 2014, 04:56 PM |
| TIDMARSH GEORGE F | President, CEO & Secretary | Sep 26, 2014 | Buy | $9.35 | 2,000 | 18,700 | 1,417,086 | Sep 30, 2014, 06:40 PM |
| TANG KEVIN C | Director | Sep 26, 2014 | Buy | $9.21 | 44,055 | 405,861 | 1,868,622 | Sep 26, 2014, 07:18 PM |
| TANG KEVIN C | Director | Sep 25, 2014 | Buy | $9.17 | 30,500 | 279,688 | 1,824,567 | Sep 26, 2014, 07:18 PM |
| TANG KEVIN C | Director | Sep 24, 2014 | Buy | $9.10 | 95,000 | 864,443 | 1,794,067 | Sep 26, 2014, 07:18 PM |
| TIDMARSH GEORGE F | President, CEO & Secretary | Sep 18, 2014 | Buy | $9.18 | 5,000 | 45,900 | 1,415,086 | Sep 22, 2014, 08:04 PM |
| Zarrabian Saiid | Director | Jul 31, 2014 | Buy | $9.53 | 381 | 3,631 | 381 | Aug 05, 2014, 05:31 PM |
| TIDMARSH GEORGE F | President, CEO & Secretary | Jul 23, 2014 | Buy | $10.50 | 19,000 | 199,500 | 1,410,086 | Jul 25, 2014, 04:11 PM |
| TIDMARSH GEORGE F | President, CEO & Secretary | May 21, 2014 | Buy | $7.37 | 12,000 | 88,440 | 20,000 | May 22, 2014, 06:28 PM |
| TIDMARSH GEORGE F | President, CEO & Secretary | Apr 14, 2014 | Buy | $9.30 | 4,000 | 37,200 | 4,000 | Apr 14, 2014, 07:47 PM |
| TIDMARSH GEORGE F | President, CEO & Secretary | Apr 11, 2014 | Buy | $9.76 | 4,000 | 39,040 | 2,000 | Apr 14, 2014, 07:47 PM |
| TIDMARSH GEORGE F | President, CEO & Secretary | Feb 07, 2014 | Buy | $7.25 | 3,000 | 21,750 | 1,391,086 | Feb 11, 2014, 01:01 PM |
| TIDMARSH GEORGE F | President, CEO and Sec'y | Sep 24, 2013 | Option Exercise | $0.07 | 1,071,429 | 75,000 | 69,404,300 | Oct 25, 2013, 08:42 PM |
| Reinisch Richard | Individual Investor | Aug 02, 2012 | Buy | $0.10 | 220,695 | 21,341 | 1,000,000 | Mar 22, 2013, 03:39 PM |
| Reinisch Richard | Individual Investor | Aug 01, 2012 | Buy | $0.10 | 279,305 | 26,590 | 779,305 | Mar 22, 2013, 03:39 PM |
| Reinisch Richard | Individual Investor | Jul 25, 2012 | Buy | $0.09 | 121,200 | 10,908 | 500,000 | Mar 22, 2013, 03:39 PM |
| Reinisch Richard | Individual Investor | Jul 24, 2012 | Buy | $0.09 | 144,780 | 12,987 | 378,800 | Mar 22, 2013, 03:39 PM |
| Reinisch Richard | Individual Investor | Jul 23, 2012 | Buy | $0.08 | 234,000 | 18,018 | 234,020 | Mar 22, 2013, 03:39 PM |
| Reinisch Richard | Individual Investor | Mar 12, 2010 | Buy | $936.20 | 20 | 18,724 | 20 | Mar 22, 2013, 03:39 PM |
| Reinisch Richard | Individual Investor | Mar 19, 2013 | Buy | $0.09 | 100,000 | 9,176 | 1,100,000 | Mar 22, 2013, 03:39 PM |
| Gillespie Deirdre | President & CEO | May 09, 2011 | Option Exercise | $0.01 | 99,166 | 595 | 99,166 | May 18, 2011, 07:55 PM |
| Gillespie Deirdre | President & CEO | May 17, 2011 | Sale | $0.02 | 99,166 | 1,587 | 0 | May 18, 2011, 07:55 PM |
| SLOAN GAIL A | Chief Financial Officer | Jun 30, 2010 | Option Exercise | $3.91 | 140 | 547 | 1,080 | Apr 21, 2011, 08:13 PM |
| SLOAN GAIL A | Chief Financial Officer | Apr 20, 2011 | Sale | $1.00 | 100 | 100 | 980 | Apr 21, 2011, 08:13 PM |
| Gillespie Deirdre | President & CEO | Apr 19, 2011 | Sale | $0.70 | 4,376 | 3,063 | 0 | Apr 20, 2011, 05:13 PM |
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| Owner | Relationship | Date | Value($) |
| RAMSAY DAVID A | Director | 08/22/2022 | 623,000 |
| TANG KEVIN C | Director | 08/22/2022 | 59,857,429 |
| Edwards Larry G. | Chief Executive Officer | 08/22/2022 | 74,567 |
| Johnson Laura L. | Director | 08/22/2022 | 3,115 |
| Johnson Craig A | Director | 08/22/2022 | 74,760 |
| Hearne Michael S | Chief Financial Officer | 08/22/2022 | 63,459 |
| Hearne Michael S | Chief Financial Officer | 08/22/2022 | 59,857,429 |
| TANG KEVIN C | Director | 08/22/2022 | 59,857,429 |
| Johnson Craig A | Director | 07/08/2022 | 47,160 |
| Hearne Michael S | Chief Financial Officer | 06/30/2022 | 640 |
| Hearne Michael S | Chief Financial Officer | 06/15/2022 | 642 |
| Hearne Michael S | Chief Financial Officer | 05/31/2022 | 644 |
| Hearne Michael S | Chief Financial Officer | 05/13/2022 | 641 |
| Hearne Michael S | Chief Financial Officer | 04/29/2022 | 642 |
| Edwards Larry G. | Chief Executive Officer | 04/14/2022 | 1,099 |
| Hearne Michael S | Chief Financial Officer | 04/14/2022 | 643 |
| Edwards Larry G. | Chief Executive Officer | 03/31/2022 | 1,212 |
| Hearne Michael S | Chief Financial Officer | 03/31/2022 | 642 |
| Edwards Larry G. | Chief Executive Officer | 03/15/2022 | 1,215 |
| Hearne Michael S | Chief Financial Officer | 03/15/2022 | 640 |
| Edwards Larry G. | Chief Executive Officer | 02/28/2022 | 1,217 |
| Hearne Michael S | Chief Financial Officer | 02/28/2022 | 643 |
| Edwards Larry G. | Chief Executive Officer | 02/15/2022 | 1,213 |
| Hearne Michael S | Chief Financial Officer | 02/15/2022 | 641 |
| Edwards Larry G. | Chief Executive Officer | 01/31/2022 | 16,411 |
| Hearne Michael S | Chief Financial Officer | 01/31/2022 | 6,592 |
| Edwards Larry G. | Chief Executive Officer | 01/14/2022 | 1,142 |
| Hearne Michael S | Chief Financial Officer | 01/14/2022 | 619 |
| Edwards Larry G. | Chief Executive Officer | 12/30/2021 | 913 |
| Edwards Larry G. | Chief Executive Officer | 12/15/2021 | 1,145 |
| Hearne Michael S | Chief Financial Officer | 12/15/2021 | 619 |
| RAMSAY DAVID A | Director | 12/03/2021 | 16,082 |
| RAMSAY DAVID A | Director | 12/02/2021 | 37,677 |
| RAMSAY DAVID A | Director | 12/06/2021 | 38,231 |
| Edwards Larry G. | Chief Executive Officer | 11/30/2021 | 1,147 |
| Hearne Michael S | Chief Financial Officer | 11/30/2021 | 617 |
| TANG KEVIN C | Director | 12/01/2021 | 663,431 |
| TANG KEVIN C | Director | 11/30/2021 | 277,612 |
| TANG KEVIN C | Director | 11/29/2021 | 793,107 |
| RAMSAY DAVID A | Director | 11/17/2021 | 31,725 |
| Edwards Larry G. | Chief Executive Officer | 11/15/2021 | 1,145 |
| Hearne Michael S | Chief Financial Officer | 11/15/2021 | 617 |
| Edwards Larry G. | Chief Executive Officer | 10/29/2021 | 1,145 |
| Hearne Michael S | Chief Financial Officer | 10/29/2021 | 618 |
| Edwards Larry G. | Chief Executive Officer | 10/15/2021 | 1,148 |
| Hearne Michael S | Chief Financial Officer | 10/15/2021 | 616 |
| Edwards Larry G. | Chief Executive Officer | 09/30/2021 | 1,146 |
| Hearne Michael S | Chief Financial Officer | 09/30/2021 | 617 |
| Edwards Larry G. | Chief Executive Officer | 09/15/2021 | 1,146 |
| Hearne Michael S | Chief Financial Officer | 09/15/2021 | 1,852 |
| Edwards Larry G. | Chief Executive Officer | 08/31/2021 | 1,145 |
| Edwards Larry G. | Chief Executive Officer | 08/13/2021 | 1,143 |
| Edwards Larry G. | Chief Executive Officer | 07/30/2021 | 1,148 |
| Hearne Michael S | Chief Financial Officer | 07/30/2021 | 617 |
| Hearne Michael S | Chief Financial Officer | 07/15/2021 | 617 |
| Edwards Larry G. | Chief Executive Officer | 07/15/2021 | 1,144 |
| Edwards Larry G. | Chief Executive Officer | 06/30/2021 | 1,146 |
| Hearne Michael S | Chief Financial Officer | 06/30/2021 | 618 |
| Edwards Larry G. | Chief Executive Officer | 05/28/2021 | 1,148 |
| Edwards Larry G. | Chief Executive Officer | 05/14/2021 | 1,144 |
| Hearne Michael S | Chief Financial Officer | 05/14/2021 | 617 |
| Edwards Larry G. | Chief Executive Officer | 04/15/2021 | 1,144 |
| Hearne Michael S | Chief Financial Officer | 04/15/2021 | 615 |
| Hearne Michael S | Chief Financial Officer | 03/15/2021 | 616 |
| Hearne Michael S | Chief Financial Officer | 02/26/2021 | 619 |
| Hearne Michael S | Chief Financial Officer | 02/12/2021 | 3,051 |
| Hearne Michael S | Chief Financial Officer | 01/29/2021 | 614 |
| Hearne Michael S | Chief Financial Officer | 01/15/2021 | 618 |
| Hearne Michael S | Chief Financial Officer | 12/31/2020 | 5,435 |
| Hearne Michael S | Chief Financial Officer | 01/15/2021 | 618 |
| Hearne Michael S | Chief Financial Officer | 12/31/2020 | 564 |
| Hearne Michael S | Chief Financial Officer | 12/15/2020 | 562 |
| Hearne Michael S | Chief Financial Officer | 11/30/2020 | 566 |
| Hearne Michael S | Chief Financial Officer | 11/13/2020 | 561 |
| Hearne Michael S | Chief Financial Officer | 10/30/2020 | 566 |
| Hearne Michael S | Chief Financial Officer | 10/15/2020 | 561 |
| Chawla Lakhmir S | Chief Medical Officer | 09/15/2020 | 1,101 |
| RAMSAY DAVID A | Director | 09/08/2020 | 3,830 |
| TANG KEVIN C | Director | 09/09/2020 | 509,940 |
| TANG KEVIN C | Director | 09/08/2020 | 328,529 |
| TANG KEVIN C | Director | 09/04/2020 | 258,359 |
| Chawla Lakhmir S | Chief Medical Officer | 08/31/2020 | 1,963 |
| RAMSAY DAVID A | Director | 08/21/2020 | 111,108 |
| RAMSAY DAVID A | Director | 08/20/2020 | 50,060 |
| RAMSAY DAVID A | Director | 08/24/2020 | 26,289 |
| Chawla Lakhmir S | Chief Medical Officer | 08/14/2020 | 1,967 |
| TANG KEVIN C | Director | 08/14/2020 | 653,694 |
| TANG KEVIN C | Director | 08/13/2020 | 800,586 |
| TANG KEVIN C | Director | 08/12/2020 | 150,820 |
| Chawla Lakhmir S | Chief Medical Officer | 07/31/2020 | 1,964 |
| Chawla Lakhmir S | Chief Medical Officer | 07/15/2020 | 1,964 |
| Chawla Lakhmir S | Chief Medical Officer | 06/30/2020 | 1,966 |
| Chawla Lakhmir S | Chief Medical Officer | 06/15/2020 | 1,962 |
| TANG KEVIN C | Director | 06/04/2020 | 1,065,636 |
| TANG KEVIN C | Director | 06/03/2020 | 714,783 |
| TANG KEVIN C | Director | 06/02/2020 | 1,237,060 |
| MULROY DENNIS | Chief Financial Officer | 05/29/2020 | 329 |
| Chawla Lakhmir S | Chief Medical Officer | 05/29/2020 | 1,969 |
| Rolke James | Chief Scientific Officer | 05/29/2020 | 822 |
| MULROY DENNIS | Chief Financial Officer | 05/15/2020 | 328 |
| Chawla Lakhmir S | Chief Medical Officer | 05/15/2020 | 1,963 |
| Rolke James | Chief Scientific Officer | 05/15/2020 | 820 |
| Rolke James | Chief Scientific Officer | 04/30/2020 | 821 |
| Chawla Lakhmir S | Chief Medical Officer | 04/30/2020 | 1,968 |
| MULROY DENNIS | Chief Financial Officer | 04/30/2020 | 327 |
| MULROY DENNIS | Chief Financial Officer | 04/15/2020 | 325 |
| Wellinghoff Darryl | Chief Commercial Officer | 04/15/2020 | 191 |
| Chawla Lakhmir S | Chief Medical Officer | 04/15/2020 | 1,964 |
| Rolke James | Chief Scientific Officer | 04/15/2020 | 819 |
| Chawla Lakhmir S | Chief Medical Officer | 03/31/2020 | 589 |
| Wellinghoff Darryl | Chief Commercial Officer | 03/31/2020 | 1,639 |
| Rolke James | Chief Scientific Officer | 03/31/2020 | 818 |
| Rolke James | Chief Scientific Officer | 03/13/2020 | 819 |
| Wellinghoff Darryl | Chief Commercial Officer | 03/13/2020 | 1,642 |
| Chawla Lakhmir S | Chief Medical Officer | 03/13/2020 | 588 |
| Rolke James | Chief Scientific Officer | 02/28/2020 | 821 |
| Chawla Lakhmir S | Chief Medical Officer | 02/28/2020 | 590 |
| Wellinghoff Darryl | Chief Commercial Officer | 02/28/2020 | 1,642 |
| Wellinghoff Darryl | Chief Commercial Officer | 02/14/2020 | 1,635 |
| Chawla Lakhmir S | Chief Medical Officer | 02/14/2020 | 593 |
| Rolke James | Chief Scientific Officer | 02/14/2020 | 821 |
| Chawla Lakhmir S | Chief Medical Officer | 01/31/2020 | 588 |
| Rolke James | Chief Scientific Officer | 01/31/2020 | 821 |
| Wellinghoff Darryl | Chief Commercial Officer | 01/31/2020 | 1,641 |
| TANG KEVIN C | Director | 02/03/2020 | 509,833 |
| TANG KEVIN C | Director | 01/31/2020 | 89,705 |
| TANG KEVIN C | Director | 01/30/2020 | 547,431 |
| Wellinghoff Darryl | Chief Commercial Officer | 01/15/2020 | 7,960 |
| Chawla Lakhmir S | Chief Medical Officer | 01/15/2020 | 3,337 |
| Rolke James | Chief Scientific Officer | 01/15/2020 | 4,636 |
| Wellinghoff Darryl | Chief Commercial Officer | 01/14/2020 | 24,677 |
| TANG KEVIN C | Director | 01/13/2020 | 8,351,580 |
| TANG KEVIN C | Director | 01/10/2020 | 4,090,909 |
| TANG KEVIN C | Director | 01/09/2020 | 4,991,980 |
| Chawla Lakhmir S | Chief Medical Officer | 12/31/2019 | 574 |
| MULROY DENNIS | Chief Financial Officer | 12/31/2019 | 53 |
| MULROY DENNIS | Chief Financial Officer | 12/13/2019 | 319 |
| Chawla Lakhmir S | Chief Medical Officer | 12/13/2019 | 573 |
| Chawla Lakhmir S | Chief Medical Officer | 11/29/2019 | 576 |
| MULROY DENNIS | Chief Financial Officer | 11/29/2019 | 322 |
| Wellinghoff Darryl | Chief Commercial Officer | 11/29/2019 | 40 |
| Rolke James | Chief Scientific Officer | 11/15/2019 | 604 |
| Wellinghoff Darryl | Chief Commercial Officer | 11/15/2019 | 1,592 |
| MULROY DENNIS | Chief Financial Officer | 11/15/2019 | 317 |
| Chawla Lakhmir S | Chief Medical Officer | 11/15/2019 | 568 |
| Rolke James | Chief Scientific Officer | 10/31/2019 | 793 |
| Wellinghoff Darryl | Chief Commercial Officer | 10/31/2019 | 1,591 |
| Chawla Lakhmir S | Chief Medical Officer | 10/31/2019 | 572 |
| MULROY DENNIS | Chief Financial Officer | 10/31/2019 | 1,591 |
| Wellinghoff Darryl | Chief Commercial Officer | 10/15/2019 | 1,595 |
| Chawla Lakhmir S | Chief Medical Officer | 10/15/2019 | 577 |
| MULROY DENNIS | Chief Financial Officer | 10/15/2019 | 1,595 |
| Rolke James | Chief Scientific Officer | 10/15/2019 | 797 |
| Rolke James | Chief Scientific Officer | 09/30/2019 | 800 |
| MULROY DENNIS | Chief Financial Officer | 09/30/2019 | 1,593 |
| Chawla Lakhmir S | Chief Medical Officer | 09/30/2019 | 568 |
| Wellinghoff Darryl | Chief Commercial Officer | 09/30/2019 | 1,593 |
| Rolke James | Chief Scientific Officer | 09/13/2019 | 789 |
| MULROY DENNIS | Chief Financial Officer | 09/13/2019 | 1,587 |
| Wellinghoff Darryl | Chief Commercial Officer | 09/13/2019 | 1,587 |
| Chawla Lakhmir S | Chief Medical Officer | 09/13/2019 | 575 |
| MULROY DENNIS | Chief Financial Officer | 08/30/2019 | 1,593 |
| Wellinghoff Darryl | Chief Commercial Officer | 08/30/2019 | 1,593 |
| Chawla Lakhmir S | Chief Medical Officer | 08/30/2019 | 569 |
| Rolke James | Chief Scientific Officer | 08/30/2019 | 797 |
| Rolke James | Chief Scientific Officer | 08/15/2019 | 794 |
| Chawla Lakhmir S | Chief Medical Officer | 08/15/2019 | 577 |
| MULROY DENNIS | Chief Financial Officer | 08/15/2019 | 1,588 |
| Wellinghoff Darryl | Chief Commercial Officer | 08/15/2019 | 1,588 |
| MULROY DENNIS | Chief Financial Officer | 07/31/2019 | 1,593 |
| Chawla Lakhmir S | Chief Medical Officer | 07/31/2019 | 569 |
| Wellinghoff Darryl | Chief Commercial Officer | 07/31/2019 | 1,593 |
| Rolke James | Chief Scientific Officer | 07/31/2019 | 796 |
| MULROY DENNIS | Chief Financial Officer | 07/15/2019 | 1,594 |
| Wellinghoff Darryl | Chief Commercial Officer | 07/15/2019 | 1,594 |
| Rolke James | Chief Scientific Officer | 07/15/2019 | 801 |
| Chawla Lakhmir S | Chief Medical Officer | 07/15/2019 | 573 |
| MULROY DENNIS | Chief Financial Officer | 06/28/2019 | 1,588 |
| Rolke James | Chief Scientific Officer | 06/28/2019 | 794 |
| Wellinghoff Darryl | Chief Commercial Officer | 06/28/2019 | 1,588 |
| Chawla Lakhmir S | Chief Medical Officer | 06/28/2019 | 574 |
| Wellinghoff Darryl | Chief Commercial Officer | 06/14/2019 | 1,592 |
| MULROY DENNIS | Chief Financial Officer | 06/14/2019 | 1,592 |
| Rolke James | Chief Scientific Officer | 06/14/2019 | 792 |
| Chawla Lakhmir S | Chief Medical Officer | 06/14/2019 | 569 |
| Chawla Lakhmir S | Chief Medical Officer | 05/31/2019 | 577 |
| Rolke James | Chief Scientific Officer | 05/31/2019 | 797 |
| Wellinghoff Darryl | Chief Commercial Officer | 05/31/2019 | 1,589 |
| MULROY DENNIS | Chief Financial Officer | 05/31/2019 | 1,589 |
| Rolke James | Chief Scientific Officer | 05/15/2019 | 798 |
| Wellinghoff Darryl | Chief Commercial Officer | 05/15/2019 | 1,590 |
| Chawla Lakhmir S | Chief Medical Officer | 05/15/2019 | 569 |
| MULROY DENNIS | Chief Financial Officer | 05/15/2019 | 1,590 |
| MULROY DENNIS | Chief Financial Officer | 04/30/2019 | 1,594 |
| Rolke James | Chief Scientific Officer | 04/30/2019 | 793 |
| Chawla Lakhmir S | Chief Medical Officer | 04/30/2019 | 575 |
| Wellinghoff Darryl | Chief Commercial Officer | 04/30/2019 | 1,594 |
| Chawla Lakhmir S | Chief Medical Officer | 04/15/2019 | 572 |
| Wellinghoff Darryl | Chief Commercial Officer | 04/15/2019 | 1,589 |
| TIDMARSH GEORGE F | President, CEO & Secretary | 04/15/2019 | 12 |
| MULROY DENNIS | Chief Financial Officer | 04/15/2019 | 1,589 |
| Rolke James | Chief Scientific Officer | 04/15/2019 | 798 |
| Rolke James | Chief Scientific Officer | 03/29/2019 | 799 |
| MULROY DENNIS | Chief Financial Officer | 03/29/2019 | 323 |
| TIDMARSH GEORGE F | President, CEO & Secretary | 03/29/2019 | 514 |
| Chawla Lakhmir S | Chief Medical Officer | 03/29/2019 | 191 |
| TIDMARSH GEORGE F | President, CEO & Secretary | 03/15/2019 | 1,266 |
| Rolke James | Chief Scientific Officer | 03/15/2019 | 792 |
| Chawla Lakhmir S | Chief Medical Officer | 03/15/2019 | 188 |
| MULROY DENNIS | Chief Financial Officer | 03/15/2019 | 318 |
| TIDMARSH GEORGE F | President, CEO & Secretary | 02/28/2019 | 1,266 |
| Rolke James | Chief Scientific Officer | 02/28/2019 | 795 |
| MULROY DENNIS | Chief Financial Officer | 02/28/2019 | 315 |
| Chawla Lakhmir S | Chief Medical Officer | 02/28/2019 | 194 |
| CARVER JENNIFER | Chief Operating Officer | 02/28/2019 | 1,115 |
| Chawla Lakhmir S | Chief Medical Officer | 02/15/2019 | 191 |
| MULROY DENNIS | Chief Financial Officer | 02/15/2019 | 318 |
| CARVER JENNIFER | Chief Operating Officer | 02/15/2019 | 1,219 |
| TIDMARSH GEORGE F | President, CEO & Secretary | 02/15/2019 | 1,267 |
| Rolke James | Chief Scientific Officer | 02/15/2019 | 800 |
| CARVER JENNIFER | Chief Operating Officer | 01/31/2019 | 6,464 |
| TIDMARSH GEORGE F | President, CEO & Secretary | 01/31/2019 | 1,262 |
| MULROY DENNIS | Chief Financial Officer | 01/31/2019 | 323 |
| Rolke James | Chief Scientific Officer | 01/31/2019 | 795 |
| Chawla Lakhmir S | Chief Medical Officer | 01/31/2019 | 190 |
| Chawla Lakhmir S | Chief Medical Officer | 01/29/2019 | 11,124 |
| Chawla Lakhmir S | Chief Medical Officer | 01/30/2019 | 5,570 |
| CARVER JENNIFER | Chief Operating Officer | 01/15/2019 | 1,223 |
| MULROY DENNIS | Chief Financial Officer | 01/15/2019 | 1,814 |
| Chawla Lakhmir S | Chief Medical Officer | 01/15/2019 | 413 |
| Rolke James | Chief Scientific Officer | 01/15/2019 | 4,546 |
| TIDMARSH GEORGE F | President, CEO & Secretary | 01/15/2019 | 5,017 |
| TANG KEVIN C | Director | 01/08/2019 | 5,962,639 |
| TANG KEVIN C | Director | 01/07/2019 | 583,840 |
| TANG KEVIN C | Director | 01/09/2019 | 438,806 |
| TIDMARSH GEORGE F | President, CEO & Secretary | 01/07/2019 | 11,700 |
| CARVER JENNIFER | Chief Operating Officer | 01/09/2019 | 30,825 |
| Rolke James | Chief Scientific Officer | 01/09/2019 | 9,746 |
| PERCEPTIVE ADVISORS LLC | 10% Owner | 01/07/2019 | 5,147,749 |
| PERCEPTIVE ADVISORS LLC | 10% Owner | 01/08/2019 | 6,568,236 |
| Chawla Lakhmir S | Chief Medical Officer | 12/31/2018 | 184 |
| Rolke James | Chief Scientific Officer | 12/31/2018 | 778 |
| MULROY DENNIS | Chief Financial Officer | 12/31/2018 | 313 |
| TIDMARSH GEORGE F | President, CEO & Secretary | 12/31/2018 | 1,234 |
| CARVER JENNIFER | Chief Operating Officer | 12/31/2018 | 1,186 |
| Chawla Lakhmir S | Chief Medical Officer | 12/14/2018 | 185 |
| MULROY DENNIS | Chief Financial Officer | 12/14/2018 | 305 |
| TIDMARSH GEORGE F | President, CEO & Secretary | 12/14/2018 | 1,219 |
| Rolke James | Chief Scientific Officer | 12/14/2018 | 762 |
| CARVER JENNIFER | Chief Operating Officer | 12/14/2018 | 1,175 |
| MULROY DENNIS | Chief Financial Officer | 11/30/2018 | 320 |
| Rolke James | Chief Scientific Officer | 11/30/2018 | 775 |
| TIDMARSH GEORGE F | President, CEO & Secretary | 11/30/2018 | 1,230 |
| Chawla Lakhmir S | Chief Medical Officer | 11/30/2018 | 197 |
| CARVER JENNIFER | Chief Operating Officer | 11/30/2018 | 1,181 |
| TIDMARSH GEORGE F | President, CEO & Secretary | 11/15/2018 | 1,229 |
| Rolke James | Chief Scientific Officer | 11/15/2018 | 773 |
| MULROY DENNIS | Chief Financial Officer | 11/15/2018 | 304 |
| CARVER JENNIFER | Chief Operating Officer | 11/15/2018 | 1,191 |
| Chawla Lakhmir S | Chief Medical Officer | 11/15/2018 | 203 |
| Rolke James | Chief Scientific Officer | 10/31/2018 | 776 |
| CARVER JENNIFER | Chief Operating Officer | 10/31/2018 | 1,178 |
| Chawla Lakhmir S | Chief Medical Officer | 10/31/2018 | 208 |
| TIDMARSH GEORGE F | President, CEO & Secretary | 10/31/2018 | 1,233 |
| MULROY DENNIS | Chief Financial Officer | 10/31/2018 | 305 |
| MULROY DENNIS | Chief Financial Officer | 10/15/2018 | 304 |
| Chawla Lakhmir S | Chief Medical Officer | 10/15/2018 | 207 |
| Rolke James | Chief Scientific Officer | 10/15/2018 | 760 |
| TIDMARSH GEORGE F | President, CEO & Secretary | 10/15/2018 | 1,215 |
| CARVER JENNIFER | Chief Operating Officer | 10/15/2018 | 1,174 |
| Rolke James | Chief Scientific Officer | 08/16/2018 | 21,997 |
| CARVER JENNIFER | Chief Operating Officer | 08/16/2018 | 20,895 |
| Douglass Laura L. | Director | 05/30/2018 | 3,000 |
| PERCEPTIVE ADVISORS LLC | 10% Owner | 03/15/2018 | 20,650,000 |
| TANG KEVIN C | Director | 03/15/2018 | 14,999,983 |
| TANG KEVIN C | Director | 03/02/2018 | 304,435 |
| TANG KEVIN C | Director | 02/28/2018 | 898,092 |
| CARVER JENNIFER | Chief Operating Officer | 02/23/2018 | 32,475 |
| TANG KEVIN C | Director | 02/27/2018 | 2,152,164 |
| TANG KEVIN C | Director | 02/26/2018 | 686,483 |
| TANG KEVIN C | Director | 02/23/2018 | 1,933,687 |
| PERCEPTIVE ADVISORS LLC | 10% Owner | 02/15/2018 | 1,621,000 |
| PERCEPTIVE ADVISORS LLC | 10% Owner | 02/14/2018 | 3,269,000 |
| PERCEPTIVE ADVISORS LLC | 10% Owner | 02/13/2018 | 2,456,250 |
| Douglass Laura L. | Director | 12/29/2017 | 89,040 |
| Douglass Laura L. | Director | 12/29/2017 | 323,208 |
| CARVER JENNIFER | Chief Operating Officer | 12/27/2017 | 33,215 |
| TANG KEVIN C | Director | 03/23/2017 | 5,000,009 |
| TIDMARSH GEORGE F | President, CEO & Secretary | 03/03/2017 | 34,150 |
| TIDMARSH GEORGE F | President, CEO & Secretary | 03/02/2017 | 68,355 |
| CARVER JENNIFER | Chief Operating Officer | 03/02/2017 | 34,460 |
| Chawla Lakhmir S | Chief Medical Officer | 03/02/2017 | 21,198 |
| Chawla Lakhmir S | Chief Medical Officer | 03/03/2017 | 34,480 |
| TANG KEVIN C | Director | 03/02/2017 | 3,463,840 |
| MULROY DENNIS | Chief Financial Officer | 03/03/2017 | 16,975 |
| TANG KEVIN C | Director | 09/09/2016 | 1,971,970 |
| TANG KEVIN C | Director | 09/13/2016 | 333,514 |
| TANG KEVIN C | Director | 09/12/2016 | 449,886 |
| TANG KEVIN C | Director | 03/04/2016 | 396,928 |
| TIDMARSH GEORGE F | President, CEO & Secretary | 03/01/2016 | 33,140 |
| TANG KEVIN C | Director | 03/03/2016 | 1,379,234 |
| TANG KEVIN C | Director | 03/02/2016 | 555,439 |
| TANG KEVIN C | Director | 03/01/2016 | 916,814 |
| Chawla Lakhmir S | Chief Medical Officer | 09/28/2015 | 13,461 |
| TANG KEVIN C | Director | 09/10/2015 | 3,040,000 |
| TANG KEVIN C | Director | 08/21/2015 | 6,922,575 |
| TANG KEVIN C | Director | 08/20/2015 | 6,709,875 |
| TANG KEVIN C | Director | 08/19/2015 | 9,413,700 |
| TANG KEVIN C | Director | 06/26/2015 | 2,593,470 |
| TANG KEVIN C | Director | 06/24/2015 | 2,026,188 |
| TANG KEVIN C | Director | 06/23/2015 | 1,198,739 |
| TANG KEVIN C | Director | 06/22/2015 | 1,666,597 |
| Zarrabian Saiid | Director | 05/14/2015 | 5,987 |
| TANG KEVIN C | Director | 05/13/2015 | 884,532 |
| TANG KEVIN C | Director | 05/12/2015 | 810,362 |
| TANG KEVIN C | Director | 05/11/2015 | 1,780,548 |
| TIDMARSH GEORGE F | President, CEO & Secretary | 05/12/2015 | 36,720 |
| TIDMARSH GEORGE F | President, CEO & Secretary | 05/12/2015 | 36,760 |
| TANG KEVIN C | Director | 12/16/2014 | 8,117 |
| TANG KEVIN C | Director | 12/15/2014 | 450,574 |
| TANG KEVIN C | Director | 12/12/2014 | 1,059,846 |
| TANG KEVIN C | Director | 12/11/2014 | 1,473,910 |
| TIDMARSH GEORGE F | President, CEO & Secretary | 12/11/2014 | 45,520 |
| TIDMARSH GEORGE F | President, CEO & Secretary | 09/26/2014 | 18,700 |
| TANG KEVIN C | Director | 09/26/2014 | 405,861 |
| TANG KEVIN C | Director | 09/25/2014 | 279,688 |
| TANG KEVIN C | Director | 09/24/2014 | 864,443 |
| TIDMARSH GEORGE F | President, CEO & Secretary | 09/18/2014 | 45,900 |
| Zarrabian Saiid | Director | 07/31/2014 | 3,631 |
| TIDMARSH GEORGE F | President, CEO & Secretary | 07/23/2014 | 199,500 |
| TIDMARSH GEORGE F | President, CEO & Secretary | 05/21/2014 | 88,440 |
| TIDMARSH GEORGE F | President, CEO & Secretary | 04/14/2014 | 37,200 |
| TIDMARSH GEORGE F | President, CEO & Secretary | 04/11/2014 | 39,040 |
| TIDMARSH GEORGE F | President, CEO & Secretary | 02/07/2014 | 21,750 |
| TIDMARSH GEORGE F | President, CEO and Sec'y | 09/24/2013 | 75,000 |
| Reinisch Richard | Individual Investor | 08/02/2012 | 21,341 |
| Reinisch Richard | Individual Investor | 08/01/2012 | 26,590 |
| Reinisch Richard | Individual Investor | 07/25/2012 | 10,908 |
| Reinisch Richard | Individual Investor | 07/24/2012 | 12,987 |
| Reinisch Richard | Individual Investor | 07/23/2012 | 18,018 |
| Reinisch Richard | Individual Investor | 03/12/2010 | 18,724 |
| Reinisch Richard | Individual Investor | 03/19/2013 | 9,176 |
| Gillespie Deirdre | President & CEO | 05/09/2011 | 595 |
| Gillespie Deirdre | President & CEO | 05/17/2011 | 1,587 |
| SLOAN GAIL A | Chief Financial Officer | 06/30/2010 | 547 |
| SLOAN GAIL A | Chief Financial Officer | 04/20/2011 | 100 |
| Gillespie Deirdre | President & CEO | 04/19/2011 | 3,063 |
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