. (IDRA)
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As of 12/31/69 07:00 PM EST. Market closed.
. (IDRA)
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As of 12/31/69 07:00 PM EST. Market closed.
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INSIDER TRANSACTIONS FOR
| Owner | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| GOWEN MAXINE | Director | Aug 10, 2023 | Sale | $0.51 | 51 | 26 | 0 | Aug 11, 2023, 04:48 PM |
| MILANO VINCENT | Director | Aug 10, 2023 | Sale | $0.53 | 3,283 | 1,750 | 8,987 | Aug 11, 2023, 04:30 PM |
| Pillar Invest Corp | 10% Owner | May 17, 2023 | Buy | $1.42 | 26,965 | 38,290 | 170,712 | Jul 19, 2023, 04:05 PM |
| Pillar Invest Corp | 10% Owner | May 17, 2023 | Buy | $1.42 | 26,965 | 38,290 | 170,712 | Jul 19, 2023, 04:05 PM |
| Pillar Invest Corp | 10% Owner | Jul 12, 2023 | Sale | $1.58 | 3,605 | 5,696 | 167,107 | Jul 19, 2023, 04:05 PM |
| Pillar Invest Corp | 10% Owner | Jul 13, 2023 | Sale | $1.54 | 2,213 | 3,408 | 164,894 | Jul 19, 2023, 04:05 PM |
| Chopra Atul | 10% Owner | May 17, 2023 | Sale | $1.33 | 24,800 | 33,104 | 1,229,701 | May 18, 2023, 02:38 PM |
| Chopra Atul | 10% Owner | May 16, 2023 | Sale | $1.42 | 32,436 | 45,972 | 1,258,658 | May 18, 2023, 02:38 PM |
| Chopra Atul | 10% Owner | May 15, 2023 | Sale | $1.48 | 78,436 | 116,371 | 1,333,943 | May 18, 2023, 02:38 PM |
| Chopra Atul | 10% Owner | May 12, 2023 | Sale | $1.56 | 81,486 | 126,947 | 1,398,426 | May 18, 2023, 02:35 PM |
| Chopra Atul | 10% Owner | May 11, 2023 | Sale | $1.84 | 47,166 | 86,924 | 1,465,748 | May 18, 2023, 02:34 PM |
| DOUGHERTY MICHAEL R | Director | Jan 11, 2023 | Option Exercise | $0.44 | 33,523 | 14,750 | 375,155 | Jan 12, 2023, 08:00 PM |
| JORDAN ANDREW R | CHIEF STRATEGY OFFICER | Jan 06, 2023 | Option Exercise | $0.71 | 73,940 | 52,490 | 839,142 | Jan 10, 2023, 09:19 PM |
| Lim Bryant David | SVP AND GENERAL COUNSEL | Jan 06, 2023 | Option Exercise | $0.71 | 119,957 | 85,157 | 309,695 | Jan 10, 2023, 09:17 PM |
| Kirby John J. | CHIEF FINANCIAL OFFICER | Jan 06, 2023 | Option Exercise | $0.71 | 119,957 | 85,157 | 316,893 | Jan 10, 2023, 09:15 PM |
| DOUGHERTY MICHAEL R | Director | Oct 03, 2022 | Option Exercise | $0.37 | 58,516 | 21,938 | 341,632 | Oct 05, 2022, 09:26 PM |
| Pillar Invest Corp | 10% Owner | Sep 22, 2022 | Option Exercise | $0.01 | 1,533,159 | 15,332 | 7,266,954 | Sep 26, 2022, 04:32 PM |
| DOUGHERTY MICHAEL R | Director | Jul 01, 2022 | Option Exercise | $0.44 | 50,086 | 21,938 | 283,116 | Jul 06, 2022, 04:30 PM |
| DOUGHERTY MICHAEL R | Director | Apr 01, 2022 | Option Exercise | $0.54 | 41,155 | 22,018 | 233,030 | Apr 05, 2022, 05:04 PM |
| Kirby John J. | CHIEF FINANCIAL OFFICER | Dec 17, 2021 | Buy | $0.62 | 10,000 | 6,150 | 37,632 | Dec 21, 2021, 04:16 PM |
| DOUGHERTY MICHAEL R | Director | Oct 04, 2021 | Option Exercise | $1.03 | 21,229 | 21,866 | 154,813 | Oct 04, 2021, 08:43 PM |
| SOLAND DANIEL B | CHIEF OPERATING OFFICER | Jun 18, 2021 | Buy | $1.19 | 50,000 | 59,500 | 78,843 | Jun 21, 2021, 04:10 PM |
| Pillar Invest Corp | 10% Owner | Apr 01, 2021 | Option Exercise | $0.01 | 1,612,196 | 16,122 | 5,733,795 | Apr 29, 2021, 09:54 PM |
| Pillar Invest Corp | 10% Owner | Apr 01, 2021 | Option Exercise | $0.01 | 883,613 | 8,836 | 2,304,180 | Apr 29, 2021, 09:54 PM |
| Pillar Invest Corp | 10% Owner | Mar 18, 2021 | Sale | $1.80 | 323,726 | 582,221 | 1,608,167 | Mar 31, 2021, 09:51 PM |
| Pillar Invest Corp | 10% Owner | Mar 18, 2021 | Sale | $1.80 | 1,376,039 | 2,474,806 | 4,121,599 | Mar 31, 2021, 09:51 PM |
| Pillar Invest Corp | 10% Owner | Mar 26, 2021 | Option Exercise | $0.01 | 884,175 | 8,842 | 2,492,342 | Mar 31, 2021, 09:51 PM |
| Pillar Invest Corp | 10% Owner | Mar 26, 2021 | Option Exercise | $0.01 | 1,611,634 | 16,116 | 5,733,233 | Mar 31, 2021, 09:51 PM |
| Pillar Invest Corp | 10% Owner | Jan 20, 2021 | Option Exercise | $0.01 | 643,525 | 6,435 | 1,931,893 | Mar 31, 2021, 09:51 PM |
| Tarka Elizabeth Ann | CHIEF MEDICAL OFFICER | Mar 25, 2021 | Sale | $1.35 | 5,018 | 6,778 | 13,237 | Mar 29, 2021, 04:14 PM |
| Lim Bryant David | SVP AND GENERAL COUNSEL | Mar 25, 2021 | Sale | $1.36 | 7,630 | 10,378 | 30,434 | Mar 29, 2021, 04:09 PM |
| Kirby John J. | CHIEF FINANCIAL OFFICER | Mar 25, 2021 | Sale | $1.42 | 6,250 | 8,876 | 27,632 | Mar 29, 2021, 04:05 PM |
| SOLAND DANIEL B | CHIEF OPERATING OFFICER | Mar 05, 2021 | Buy | $3.89 | 10,000 | 38,950 | 28,843 | Mar 05, 2021, 05:55 PM |
| Kirby John J. | Chief Financial Officer | Jan 12, 2021 | Sale | $4.22 | 1,693 | 7,152 | 33,882 | Jan 12, 2021, 07:12 PM |
| Tarka Elizabeth Ann | Chief Medical Officer | Jan 12, 2021 | Sale | $4.19 | 1,745 | 7,310 | 18,255 | Jan 12, 2021, 07:10 PM |
| Lim Bryant David | SVP and General Counsel | Jan 12, 2021 | Sale | $4.21 | 1,711 | 7,202 | 38,064 | Jan 12, 2021, 07:08 PM |
| MILANO VINCENT | President & CEO | Jan 12, 2021 | Sale | $4.20 | 3,210 | 13,474 | 208,611 | Jan 12, 2021, 07:00 PM |
| Lim Bryant David | SVP and General Counsel | Jan 05, 2021 | Sale | $3.91 | 1,465 | 5,722 | 39,775 | Jan 11, 2021, 08:15 PM |
| MILANO VINCENT | President & CEO | Jan 05, 2021 | Sale | $3.91 | 2,740 | 10,700 | 211,821 | Jan 11, 2021, 08:09 PM |
| Kirby John J. | Chief Financial Officer | Jan 05, 2021 | Sale | $3.90 | 862 | 3,362 | 35,575 | Jan 06, 2021, 05:04 PM |
| SCHAFER CAROL | Director | Jan 04, 2021 | Option Exercise | $4.02 | 3,620 | 14,552 | 48,488 | Jan 06, 2021, 12:00 AM |
| DOUGHERTY MICHAEL R | Director | Jan 04, 2021 | Option Exercise | $4.02 | 3,515 | 14,130 | 37,645 | Jan 06, 2021, 12:00 AM |
| Goldberg Mark Alan | Director | Jan 04, 2021 | Option Exercise | $4.02 | 3,452 | 13,877 | 38,099 | Jan 06, 2021, 12:00 AM |
| GERAGHTY JAMES A | Director | Jan 04, 2021 | Option Exercise | $4.02 | 4,851 | 19,501 | 104,770 | Jan 06, 2021, 12:00 AM |
| MILANO VINCENT | President & CEO | Dec 22, 2020 | Sale | $4.32 | 37,169 | 160,525 | 214,561 | Dec 22, 2020, 06:45 PM |
| Pillar Invest Corp | 10% Owner | Dec 11, 2020 | Buy | $1.82 | 69,941 | 127,293 | 5,497,638 | Dec 15, 2020, 06:00 PM |
| SCHAFER CAROL | Director | Oct 01, 2020 | Option Exercise | $2.25 | 6,111 | 13,750 | 44,868 | Oct 05, 2020, 04:07 PM |
| PIEN HOWARD H | Director | Oct 01, 2020 | Option Exercise | $2.25 | 5,583 | 12,562 | 45,457 | Oct 05, 2020, 04:07 PM |
| Goldberg Mark Alan | Director | Oct 01, 2020 | Option Exercise | $2.25 | 6,166 | 13,874 | 34,647 | Oct 05, 2020, 04:06 PM |
| GERAGHTY JAMES A | Director | Oct 01, 2020 | Option Exercise | $2.25 | 8,666 | 19,499 | 99,919 | Oct 05, 2020, 04:06 PM |
| DOUGHERTY MICHAEL R | Director | Oct 01, 2020 | Option Exercise | $2.25 | 5,722 | 12,875 | 34,130 | Oct 05, 2020, 04:05 PM |
| Pillar Invest Corp | 10% Owner | Jul 13, 2020 | Buy | $1.72 | 749,993 | 1,289,988 | 5,427,697 | Jul 15, 2020, 06:16 PM |
| SCHAFER CAROL | Director | Jul 01, 2020 | Option Exercise | $1.79 | 7,681 | 13,749 | 38,757 | Jul 02, 2020, 08:59 PM |
| PIEN HOWARD H | Director | Jul 01, 2020 | Option Exercise | $1.79 | 7,018 | 12,562 | 39,874 | Jul 02, 2020, 08:58 PM |
| Goldberg Mark Alan | Director | Jul 01, 2020 | Option Exercise | $1.79 | 7,751 | 13,874 | 28,481 | Jul 02, 2020, 08:58 PM |
| GERAGHTY JAMES A | Director | Jul 01, 2020 | Option Exercise | $1.79 | 10,894 | 19,500 | 91,253 | Jul 02, 2020, 08:57 PM |
| DOUGHERTY MICHAEL R | Director | Jul 01, 2020 | Option Exercise | $1.79 | 7,193 | 12,875 | 28,408 | Jul 02, 2020, 08:55 PM |
| Pillar Invest Corp | 10% Owner | Apr 07, 2020 | Buy | $1.52 | 3,039,514 | 4,620,061 | 6,260,832 | Apr 09, 2020, 06:44 PM |
| SCHAFER CAROL | Director | Apr 01, 2020 | Option Exercise | $1.28 | 10,633 | 13,610 | 31,076 | Apr 03, 2020, 05:21 PM |
| PIEN HOWARD H | Director | Apr 01, 2020 | Option Exercise | $1.28 | 9,666 | 12,372 | 32,856 | Apr 03, 2020, 05:20 PM |
| Goldberg Mark Alan | Director | Apr 01, 2020 | Option Exercise | $1.28 | 10,730 | 13,734 | 20,730 | Apr 03, 2020, 05:19 PM |
| GERAGHTY JAMES A | Director | Apr 01, 2020 | Option Exercise | $1.28 | 14,926 | 19,105 | 80,359 | Apr 03, 2020, 05:18 PM |
| DOUGHERTY MICHAEL R | Director | Apr 01, 2020 | Option Exercise | $1.28 | 10,059 | 12,876 | 21,215 | Apr 03, 2020, 05:16 PM |
| Pillar Invest Corp | 10% Owner | Jan 29, 2020 | Sale | $1.76 | 17,250 | 30,438 | 3,254,442 | Feb 26, 2020, 05:12 PM |
| Pillar Invest Corp | 10% Owner | Jan 28, 2020 | Sale | $1.76 | 12,532 | 22,081 | 3,271,692 | Feb 26, 2020, 05:12 PM |
| Pillar Invest Corp | 10% Owner | Jan 27, 2020 | Sale | $1.77 | 15,000 | 26,550 | 3,284,224 | Feb 26, 2020, 05:12 PM |
| YINGLING JONATHAN MICHAEL | Chief Scientific Officer | Jan 07, 2020 | Sale | $1.78 | 1,742 | 3,101 | 16,358 | Jan 14, 2020, 06:11 PM |
| Lim Bryant David | SVP and General Counsel | Jan 07, 2020 | Sale | $1.78 | 1,603 | 2,854 | 21,240 | Jan 14, 2020, 06:10 PM |
| Fletcher Robert C. | Sr. VP, Bus. Dev. & Strategy | Jan 07, 2020 | Sale | $1.78 | 1,615 | 2,875 | 16,485 | Jan 14, 2020, 06:09 PM |
| Kirby John J. | Chief Financial Officer | Jan 07, 2020 | Sale | $1.78 | 911 | 1,622 | 16,437 | Jan 14, 2020, 06:07 PM |
| MILANO VINCENT | President & CEO | Jan 07, 2020 | Sale | $1.78 | 3,006 | 5,352 | 86,560 | Jan 14, 2020, 06:05 PM |
| YINGLING JONATHAN MICHAEL | Chief Scientific Officer | Jan 07, 2020 | Sale | $1.78 | 1,742 | 3,101 | 16,358 | Jan 10, 2020, 08:16 AM |
| MILANO VINCENT | President & CEO | Jan 07, 2020 | Sale | $1.78 | 3,006 | 5,352 | 86,560 | Jan 10, 2020, 08:14 AM |
| Kirby John J. | Chief Financial Officer | Jan 07, 2020 | Sale | $1.78 | 911 | 1,622 | 16,437 | Jan 10, 2020, 08:11 AM |
| Fletcher Robert C. | Sr. VP, Bus. Dev. & Strategy | Jan 07, 2020 | Sale | $1.78 | 1,615 | 2,875 | 16,485 | Jan 10, 2020, 08:09 AM |
| Lim Bryant David | SVP and General Counsel | Jan 07, 2020 | Sale | $1.78 | 1,603 | 2,854 | 21,240 | Jan 10, 2020, 08:07 AM |
| DOUGHERTY MICHAEL R | Director | Jan 02, 2020 | Option Exercise | $1.85 | 7,037 | 13,018 | 11,156 | Jan 06, 2020, 04:09 PM |
| PIEN HOWARD H | Director | Jan 02, 2020 | Option Exercise | $1.85 | 6,790 | 12,562 | 23,190 | Jan 06, 2020, 04:08 PM |
| Pillar Invest Corp | 10% Owner | Nov 06, 2019 | Sale | $2.50 | 100,000 | 249,560 | 3,318,224 | Nov 08, 2019, 06:56 PM |
| Pillar Invest Corp | 10% Owner | Nov 08, 2019 | Sale | $2.44 | 9,000 | 21,960 | 3,299,224 | Nov 08, 2019, 06:56 PM |
| Pillar Invest Corp | 10% Owner | Nov 07, 2019 | Sale | $2.45 | 10,000 | 24,500 | 3,308,224 | Nov 08, 2019, 06:56 PM |
| PIEN HOWARD H | Director | Oct 01, 2019 | Option Exercise | $2.67 | 4,610 | 12,309 | 16,400 | Oct 02, 2019, 08:56 PM |
| DOUGHERTY MICHAEL R | Director | Oct 01, 2019 | Option Exercise | $2.67 | 4,119 | 10,998 | 4,119 | Oct 02, 2019, 08:56 PM |
| SCHAFER CAROL | Director | Oct 01, 2019 | Option Exercise | $2.67 | 5,098 | 13,612 | 20,443 | Oct 02, 2019, 08:55 PM |
| BAKER BROS. ADVISORS LP | 10% Owner | Jul 01, 2019 | Option Exercise | $2.61 | 5,928 | 15,472 | 4,290,995 | Jul 03, 2019, 01:15 PM |
| PIEN HOWARD H | Director | Jul 01, 2019 | Option Exercise | $2.61 | 4,469 | 11,664 | 11,790 | Jul 02, 2019, 04:39 PM |
| SCHAFER CAROL | Director | Jul 01, 2019 | Option Exercise | $2.61 | 5,179 | 13,517 | 15,345 | Jul 02, 2019, 04:38 PM |
| BAKER BROS. ADVISORS LP | Director | Apr 01, 2019 | Option Exercise | $2.59 | 12,483 | 32,331 | 4,288,031 | Apr 03, 2019, 05:36 PM |
| PIEN HOWARD H | Director | Apr 01, 2019 | Option Exercise | $2.59 | 4,392 | 11,375 | 7,321 | Apr 02, 2019, 05:17 PM |
| SCHAFER CAROL | Director | Apr 01, 2019 | Option Exercise | $2.59 | 5,166 | 13,380 | 10,166 | Apr 02, 2019, 05:17 PM |
| BAKER BROS. ADVISORS LP | Director | Jan 02, 2019 | Option Exercise | $3.52 | 10,974 | 38,628 | 4,283,870 | Jan 04, 2019, 04:52 PM |
| PIEN HOWARD H | Director | Jan 02, 2019 | Option Exercise | $3.52 | 2,929 | 10,310 | 2,929 | Jan 03, 2019, 04:41 PM |
| MILANO VINCENT | President & CEO | Dec 24, 2018 | Buy | $2.93 | 15,000 | 43,923 | 55,816 | Dec 26, 2018, 09:21 AM |
| Lim Bryant David | SVP and General Counsel | Dec 21, 2018 | Buy | $3.05 | 4,000 | 12,200 | 4,743 | Dec 26, 2018, 09:17 AM |
| Horobin Joanna | Chief Medical Officer | Dec 20, 2018 | Buy | $3.45 | 300 | 1,035 | 2,044 | Dec 20, 2018, 05:27 PM |
| Goldberg Mark Alan | Director | Dec 19, 2018 | Buy | $3.19 | 10,000 | 31,897 | 10,000 | Dec 20, 2018, 05:26 PM |
| SCHAFER CAROL | Director | Dec 19, 2018 | Buy | $3.33 | 5,000 | 16,671 | 5,000 | Dec 20, 2018, 05:25 PM |
| BAKER BROS. ADVISORS LP | Director | Oct 01, 2018 | Option Exercise | $8.71 | 7,020 | 61,144 | 4,280,212 | Oct 03, 2018, 08:37 PM |
| Pillar Invest Corp | 10% Owner | Aug 08, 2018 | Sale | $5.91 | 78,107 | 461,449 | 0 | Aug 17, 2018, 05:44 PM |
| Pillar Invest Corp | 10% Owner | Aug 07, 2018 | Sale | $5.58 | 166,893 | 931,816 | 0 | Aug 17, 2018, 05:44 PM |
| Pillar Invest Corp | 10% Owner | Aug 09, 2018 | Sale | $6.30 | 55,000 | 346,443 | 0 | Aug 17, 2018, 05:44 PM |
| MILANO VINCENT | President & CEO | Aug 07, 2018 | Buy | $5.51 | 10,000 | 55,100 | 40,816 | Aug 08, 2018, 07:35 PM |
| GERAGHTY JAMES A | Director | Aug 07, 2018 | Buy | $5.58 | 10,000 | 55,800 | 65,433 | Aug 08, 2018, 07:35 PM |
| Pillar Invest Corp | 10% Owner | Jul 18, 2018 | Sale | $0.85 | 1,725,000 | 1,470,390 | 0 | Jul 24, 2018, 05:52 PM |
| Pillar Invest Corp | 10% Owner | Jul 20, 2018 | Sale | $0.86 | 492,567 | 422,672 | 0 | Jul 24, 2018, 05:52 PM |
| Pillar Invest Corp | 10% Owner | Jul 19, 2018 | Sale | $0.88 | 556,000 | 489,502 | 0 | Jul 24, 2018, 05:52 PM |
| Pillar Invest Corp | 10% Owner | Jul 17, 2018 | Sale | $0.99 | 874,505 | 862,524 | 0 | Jul 19, 2018, 06:13 PM |
| Pillar Invest Corp | 10% Owner | Jul 16, 2018 | Sale | $1.01 | 735,771 | 743,644 | 0 | Jul 19, 2018, 06:13 PM |
| Pillar Invest Corp | 10% Owner | Jul 13, 2018 | Sale | $1.05 | 250,500 | 264,052 | 0 | Jul 19, 2018, 06:13 PM |
| BAKER BROS. ADVISORS LP | Director | Jul 02, 2018 | Option Exercise | $1.32 | 49,149 | 64,877 | 34,222,983 | Jul 05, 2018, 05:52 PM |
| GERAGHTY JAMES A | Director | Jul 02, 2018 | Option Exercise | $1.32 | 8,096 | 10,687 | 443,465 | Jul 05, 2018, 02:53 PM |
| BAKER BROS. ADVISORS LP | Director | Apr 02, 2018 | Option Exercise | $1.62 | 40,047 | 64,876 | 34,206,600 | Apr 04, 2018, 04:55 PM |
| BAKER BROS. ADVISORS LP | Director | Mar 15, 2018 | Option Exercise | $0.47 | 20,316,327 | 9,548,674 | 34,193,251 | Mar 15, 2018, 04:10 PM |
| Pillar Invest Corp | 10% Owner | Jan 17, 2018 | Sale | $2.40 | 200,000 | 480,000 | 0 | Jan 19, 2018, 04:51 PM |
| BAKER BROS. ADVISORS LP | Director | Jan 02, 2018 | Option Exercise | $2.21 | 27,999 | 61,878 | 16,566,806 | Jan 04, 2018, 04:04 PM |
| Pillar Invest Corp | 10% Owner | Dec 15, 2017 | Sale | $1.91 | 33,830 | 64,527 | 0 | Dec 15, 2017, 05:50 PM |
| Pillar Invest Corp | 10% Owner | Dec 14, 2017 | Sale | $2.00 | 1,166,170 | 2,332,601 | 0 | Dec 15, 2017, 05:50 PM |
| Pillar Invest Corp | 10% Owner | Dec 13, 2017 | Sale | $1.93 | 1,100,000 | 2,118,170 | 0 | Dec 15, 2017, 05:50 PM |
| BAKER BROS. ADVISORS LP | Director | Oct 26, 2017 | Buy | $1.50 | 8,000,000 | 12,000,000 | 16,557,473 | Oct 30, 2017, 05:12 PM |
| ZEIN YOUSSEF EL | Director | Oct 02, 2017 | Option Exercise | $2.28 | 4,721 | 10,764 | 539,410 | Oct 05, 2017, 04:18 PM |
| BAKER BROS. ADVISORS LP | Director | Oct 02, 2017 | Option Exercise | $2.28 | 27,135 | 61,868 | 9,352,821 | Oct 04, 2017, 07:22 PM |
| ZEIN YOUSSEF EL | Director | Oct 02, 2017 | Option Exercise | $2.28 | 4,721 | 10,764 | 534,980 | Oct 04, 2017, 04:30 PM |
| ZEIN YOUSSEF EL | Director | Jul 03, 2017 | Option Exercise | $1.75 | 6,151 | 10,764 | 530,259 | Jul 07, 2017, 01:09 PM |
| REARDON WILLIAM S | Director | Jul 03, 2017 | Option Exercise | $1.75 | 7,714 | 13,500 | 32,973 | Jul 07, 2017, 11:01 AM |
| BAKER BROS. ADVISORS LP | Director | Jul 03, 2017 | Option Exercise | $1.75 | 35,361 | 61,882 | 9,343,776 | Jul 06, 2017, 04:06 PM |
| Pillar Invest Corp | Director | May 01, 2017 | Sale | $2.26 | 450,815 | 1,018,436 | 0 | May 03, 2017, 07:38 PM |
| Pillar Invest Corp | Director | Apr 25, 2017 | Sale | $2.29 | 890,593 | 2,037,944 | 0 | Apr 26, 2017, 05:59 PM |
| Pillar Invest Corp | Director | Apr 24, 2017 | Sale | $2.29 | 437,829 | 1,002,059 | 0 | Apr 26, 2017, 05:59 PM |
| ZEIN YOUSSEF EL | Director | Apr 03, 2017 | Option Exercise | $2.43 | 4,430 | 10,765 | 528,538 | Apr 06, 2017, 04:05 PM |
| BAKER BROS. ADVISORS LP | Director | Apr 03, 2017 | Option Exercise | $2.43 | 25,461 | 61,870 | 9,331,989 | Apr 05, 2017, 04:59 PM |
| BAKER JULIAN | Director | Jan 03, 2017 | Option Exercise | $1.50 | 42,507 | 63,761 | 9,323,502 | Jan 05, 2017, 07:00 PM |
| ZEIN YOUSSEF EL | Director | Jan 04, 2017 | Option Exercise | $1.50 | 7,216 | 10,824 | 524,108 | Jan 05, 2017, 04:29 PM |
| GOWEN MAXINE | Director | Jan 04, 2017 | Option Exercise | $1.50 | 7,000 | 10,500 | 17,543 | Jan 05, 2017, 04:29 PM |
| BAKER JULIAN | Director | Oct 07, 2016 | Buy | $2.00 | 3,250,000 | 6,500,000 | 9,309,333 | Oct 11, 2016, 05:45 PM |
| ZEIN YOUSSEF EL | Director | Oct 03, 2016 | Buy | $2.56 | 4,228 | 10,824 | 516,892 | Oct 05, 2016, 04:53 PM |
| GOWEN MAXINE | Director | Oct 03, 2016 | Buy | $2.56 | 4,102 | 10,501 | 10,543 | Oct 05, 2016, 04:52 PM |
| BAKER JULIAN | Director | Oct 03, 2016 | Option Exercise | $2.56 | 24,897 | 63,736 | 6,380,737 | Oct 05, 2016, 04:30 PM |
| BAKER JULIAN | Director | Jul 01, 2016 | Option Exercise | $1.63 | 39,114 | 63,756 | 6,372,438 | Jul 06, 2016, 06:21 PM |
| GERAGHTY JAMES A | Director | Jul 01, 2016 | Option Exercise | $1.63 | 9,720 | 15,844 | 435,369 | Jul 06, 2016, 05:16 PM |
| ZEIN YOUSSEF EL | Director | Jul 01, 2016 | Option Exercise | $1.63 | 6,641 | 10,825 | 512,664 | Jul 06, 2016, 05:16 PM |
| GOWEN MAXINE | Director | Jul 01, 2016 | Option Exercise | $1.63 | 6,441 | 10,499 | 6,441 | Jul 06, 2016, 05:16 PM |
| REARDON WILLIAM S | Director | Jul 01, 2016 | Option Exercise | $1.63 | 4,102 | 6,686 | 25,259 | Jul 06, 2016, 05:15 PM |
| GERAGHTY JAMES A | Director | May 13, 2016 | Buy | $1.34 | 10,000 | 13,400 | 425,649 | May 16, 2016, 06:07 AM |
| Casey Mark J | Senior VP & General Counsel | May 12, 2016 | Buy | $1.44 | 34,450 | 49,608 | 34,450 | May 13, 2016, 09:00 AM |
| BAKER JULIAN | Director | Apr 01, 2016 | Option Exercise | $1.97 | 32,364 | 63,757 | 6,359,400 | Apr 05, 2016, 06:00 PM |
| ZEIN YOUSSEF EL | Director | Apr 01, 2016 | Option Exercise | $1.97 | 5,495 | 10,825 | 506,023 | Apr 05, 2016, 09:52 AM |
| MILANO VINCENT | President & CEO | Mar 15, 2016 | Buy | $1.97 | 40,000 | 78,800 | 246,527 | Mar 17, 2016, 08:23 PM |
| BAKER JULIAN | Director | Jan 04, 2016 | Option Exercise | $3.00 | 21,246 | 63,738 | 6,348,612 | Jan 06, 2016, 06:02 PM |
| ZEIN YOUSSEF EL | Director | Jan 04, 2016 | Option Exercise | $3.00 | 3,608 | 10,824 | 500,528 | Jan 06, 2016, 04:02 PM |
| BAKER JULIAN | Director | Oct 01, 2015 | Option Exercise | $3.06 | 20,835 | 63,755 | 6,341,530 | Oct 05, 2015, 06:59 PM |
| ZEIN YOUSSEF EL | Director | Oct 01, 2015 | Option Exercise | $3.06 | 3,537 | 10,823 | 496,920 | Oct 05, 2015, 04:35 PM |
| ZEIN YOUSSEF EL | Director | Jul 01, 2015 | Option Exercise | $3.66 | 2,957 | 10,823 | 493,383 | Jul 06, 2015, 06:45 PM |
| BAKER JULIAN | Director | Jul 01, 2015 | Option Exercise | $3.66 | 15,780 | 57,755 | 6,334,585 | Jul 06, 2015, 06:25 PM |
| GERAGHTY JAMES A | Director | Apr 01, 2015 | Option Exercise | $3.52 | 3,000 | 10,560 | 415,649 | Apr 06, 2015, 04:18 PM |
| ZEIN YOUSSEF EL | Director | Apr 01, 2015 | Option Exercise | $3.52 | 3,075 | 10,824 | 490,426 | Apr 03, 2015, 05:57 PM |
| BAKER JULIAN | Director | Apr 01, 2015 | Option Exercise | $3.52 | 16,410 | 57,763 | 6,329,325 | Apr 02, 2015, 07:09 PM |
| ZEIN YOUSSEF EL | Director | Mar 17, 2015 | Option Exercise | $4.80 | 1,250 | 6,000 | 487,351 | Mar 19, 2015, 04:28 PM |
| BAKER JULIAN | Director | Feb 13, 2015 | Buy | $3.75 | 5,333,333 | 19,999,999 | 6,323,855 | Feb 17, 2015, 07:39 AM |
| BAKER JULIAN | Director | Jan 02, 2015 | Option Exercise | $4.90 | 11,781 | 57,727 | 1,425,446 | Jan 06, 2015, 08:32 PM |
| ZEIN YOUSSEF EL | Director | Dec 16, 2014 | Sale | $3.68 | 100,000 | 368,220 | 486,101 | Dec 16, 2014, 06:54 PM |
| MILANO VINCENT | President and CEO | Dec 12, 2014 | Buy | $4.00 | 200,000 | 799,100 | 200,000 | Dec 15, 2014, 05:01 PM |
| BAKER JULIAN | Director | Oct 01, 2014 | Option Exercise | $2.16 | 26,742 | 57,763 | 1,421,519 | Oct 03, 2014, 05:55 PM |
| REARDON WILLIAM S | Director | Jul 01, 2014 | Option Exercise | $2.83 | 2,363 | 6,687 | 21,157 | Jul 03, 2014, 04:44 PM |
| MacCoss Malcolm | Director | Jul 01, 2014 | Option Exercise | $2.83 | 662 | 1,873 | 3,753 | Jul 03, 2014, 04:25 PM |
| BAKER JULIAN | Director | Jul 01, 2014 | Option Exercise | $2.83 | 18,546 | 52,485 | 1,412,605 | Jul 03, 2014, 02:32 PM |
| GERAGHTY JAMES A | Director | May 27, 2014 | Buy | $2.65 | 10,000 | 26,500 | 412,649 | May 29, 2014, 04:27 PM |
| Sullivan Timothy M | VP Development Programs | May 27, 2014 | Option Exercise | $0.90 | 160,599 | 145,137 | 185,513 | May 29, 2014, 04:26 PM |
| Sullivan Timothy M | VP Development Programs | May 27, 2014 | Sale | $2.73 | 160,599 | 438,500 | 24,914 | May 29, 2014, 04:26 PM |
| Abdul-Wahab Umari | Director | Apr 01, 2014 | Option Exercise | $4.41 | 1,984 | 8,749 | 67,304 | Apr 03, 2014, 04:15 PM |
| GERAGHTY JAMES A | Director | Apr 01, 2014 | Option Exercise | $4.41 | 1,636 | 7,215 | 402,649 | Apr 03, 2014, 04:14 PM |
| Abdul-Wahab Umari | Director | Jan 02, 2014 | Option Exercise | $4.75 | 1,842 | 8,750 | 65,320 | Jan 06, 2014, 04:15 PM |
| GERAGHTY JAMES A | Director | Jan 02, 2014 | Option Exercise | $4.75 | 1,013 | 4,812 | 401,013 | Jan 06, 2014, 04:13 PM |
| GERAGHTY JAMES A | Director | Dec 06, 2013 | Buy | $2.72 | 40,000 | 108,800 | 400,000 | Dec 09, 2013, 05:52 PM |
| Abdul-Wahab Umari | Director | Oct 01, 2013 | Option Exercise | $1.80 | 4,861 | 8,750 | 63,478 | Oct 03, 2013, 04:22 PM |
| KARR ROBERT W | Director | Sep 16, 2013 | Buy | $1.76 | 5,750 | 10,114 | 6,299 | Sep 18, 2013, 04:23 PM |
| REARDON WILLIAM S | Director | Sep 16, 2013 | Buy | $1.82 | 13,561 | 24,643 | 18,794 | Sep 17, 2013, 05:21 PM |
| GERAGHTY JAMES A | Director | Sep 16, 2013 | Buy | $1.90 | 60,000 | 114,000 | 360,000 | Sep 16, 2013, 05:21 PM |
| GERAGHTY JAMES A | Director | Aug 19, 2013 | Buy | $1.75 | 300,000 | 525,000 | 300,000 | Aug 20, 2013, 04:29 PM |
| Abdul-Wahab Umari | Director | Jul 01, 2013 | Option Exercise | $0.70 | 12,500 | 8,750 | 58,617 | Jul 03, 2013, 02:13 PM |
| HARTLEY C KEITH | Director | May 07, 2013 | Buy | $0.49 | 90,000 | 44,100 | 92,434 | May 09, 2013, 04:21 PM |
| Abdul-Wahab Umari | Director | Apr 01, 2013 | Option Exercise | $0.47 | 18,617 | 8,750 | 18,617 | Apr 03, 2013, 09:00 PM |
| MacCoss Malcolm | Director | Jul 02, 2012 | Option Exercise | $1.17 | 1,216 | 1,424 | 3,091 | Jul 02, 2012, 05:24 PM |
| Senator Investment Group LP | 10% Owner | Apr 23, 2012 | Sale | $1.88 | 91,000 | 171,080 | 2,724,700 | Apr 25, 2012, 04:27 PM |
| Senator Investment Group LP | 10% Owner | Apr 20, 2012 | Sale | $2.00 | 27,300 | 54,600 | 2,815,700 | Apr 23, 2012, 03:10 PM |
| Senator Investment Group LP | 10% Owner | Apr 19, 2012 | Sale | $2.01 | 37,000 | 74,370 | 2,843,000 | Apr 23, 2012, 03:10 PM |
| Senator Investment Group LP | 10% Owner | Apr 18, 2012 | Sale | $2.09 | 42,000 | 87,780 | 2,880,000 | Apr 19, 2012, 03:00 PM |
| Senator Investment Group LP | 10% Owner | Apr 17, 2012 | Sale | $2.15 | 78,000 | 167,700 | 2,996,000 | Apr 19, 2012, 03:00 PM |
| Senator Investment Group LP | 10% Owner | Apr 11, 2012 | Sale | $1.85 | 26,300 | 48,655 | 3,000,000 | Apr 13, 2012, 12:35 PM |
| Senator Investment Group LP | 10% Owner | Apr 09, 2012 | Sale | $1.91 | 15,200 | 29,032 | 3,108,300 | Apr 11, 2012, 04:27 PM |
| Senator Investment Group LP | 10% Owner | Apr 10, 2012 | Sale | $1.87 | 82,000 | 153,340 | 3,026,300 | Apr 11, 2012, 04:27 PM |
| Senator Investment Group LP | 10% Owner | Mar 30, 2012 | Sale | $1.88 | 61,624 | 115,586 | 3,173,500 | Apr 04, 2012, 05:17 PM |
| Senator Investment Group LP | 10% Owner | Mar 29, 2012 | Sale | $1.92 | 49,381 | 94,812 | 3,185,124 | Apr 04, 2012, 05:17 PM |
| ZEIN YOUSSEF EL | Director | Jul 01, 2011 | Option Exercise | $2.23 | 5,707 | 12,727 | 586,101 | Jul 01, 2011, 05:39 PM |
| ZEIN YOUSSEF EL | Director | Apr 01, 2011 | Option Exercise | $2.64 | 4,821 | 12,727 | 580,394 | Apr 01, 2011, 08:02 PM |
| ZEIN YOUSSEF EL | Director | Jan 03, 2011 | Option Exercise | $2.89 | 4,404 | 12,728 | 575,573 | Jan 05, 2011, 07:43 PM |
| ZEIN YOUSSEF EL | Director | Dec 01, 2010 | Buy | $2.52 | 7,000 | 17,645 | 571,169 | Dec 03, 2010, 09:39 AM |
| ZEIN YOUSSEF EL | Director | Nov 12, 2010 | Buy | $2.82 | 25,029 | 70,582 | 564,169 | Nov 15, 2010, 09:56 AM |
| Sullivan Timothy M | VP Development Programs | Nov 10, 2010 | Sale | $2.72 | 3,837 | 10,437 | 24,914 | Nov 12, 2010, 04:53 PM |
| ZEIN YOUSSEF EL | Director | Nov 10, 2010 | Buy | $2.75 | 13,000 | 35,750 | 539,140 | Nov 12, 2010, 08:32 AM |
| HARTLEY C KEITH | Director | Nov 10, 2010 | Buy | $2.79 | 10,000 | 27,930 | 54,184 | Nov 10, 2010, 06:42 PM |
| ZEIN YOUSSEF EL | Director | Nov 09, 2010 | Buy | $2.79 | 10,000 | 27,900 | 526,140 | Nov 10, 2010, 11:24 AM |
| ZEIN YOUSSEF EL | Director | Nov 08, 2010 | Buy | $2.76 | 19,000 | 52,440 | 516,140 | Nov 10, 2010, 11:24 AM |
| MacCoss Malcolm | Director | Oct 01, 2010 | Option Exercise | $3.30 | 1,875 | 6,187 | 1,875 | Oct 04, 2010, 04:22 PM |
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