Genomic Health, Inc.. (GHDX) NASDAQ
$63.44 - (-)
Market Cap: -
As of 11/07/19 04:00 PM EST. Market closed.
Genomic Health, Inc.. (GHDX)
NASDAQ
$63.44
- (-)
Market Cap: -
As of 11/07/19 04:00 PM EST. Market closed.
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Genomic Health, Inc. engages in the provision of genomic-based diagnostic tests. Its tests analyze the underlying biology of cancers, allowing physicians and patients to make individualized treatment decisions. The firm uses a platform which translates a massive amount of clinical and genomic data into clinically actionable results for treatment planning. Genomic Health was founded by Patrick F. ... read more
Genomic Health, Inc. engages in the provision of genomic-based diagnostic tests. Its tests analyze the underlying biology of cancers, allowing physicians and patients to make individualized treatment decisions. The firm uses a platform which translates a massive amount of clinical and genomic data into clinically actionable results for treatment planning. Genomic Health was founded by Patrick F. Terry, Joffre B. Baker, Randal W. Scott, and Steven Shak in August 2000 and is headquartered in Redwood City, CA. read less
COMPANY PROFILE
Sector
Health Technology
Industry
Biotechnology
CEO Compensation (Base)
$720,400
CEO Compensation (Total)
$4.76M
Sector
Health Technology
Industry
Biotechnology
CEO Compensation (Base)
$720,400
CEO Compensation (Total)
$4.76M
Address
301 Penobscot Drive, CA, Redwood City, 94063.
PRICE CHART FOR GENOMIC HEALTH, INC.
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NEWS
INSIDEARBITRAGE ARTICLES
KEY STATS
Open
-
Previous Close
-
Days Range
- - -
52 week range
$50.77 - $86.70
Volume
0
Avg. Volume (30 days)
806,758
Market Cap
-
Dividend Yield
-
P/E
-
Shares Outstanding
0
Open
-
Previous Close
-
Days Range
- - -
52 week range
$50.77 - $86.70
Volume
0
Avg. Volume (30 days)
806,758
Market Cap
-
Dividend Yield
-
P/E
-
Shares Outstanding
0
FINANCIAL STATEMENTS FOR GENOMIC HEALTH, INC.
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INSIDER TRANSACTIONS FOR GENOMIC HEALTH, INC.
| Owner | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| Leber Laura | Chief Communication Officer | Oct 17, 2019 | Option Exercise | $22.98 | 13,183 | 302,945 | 26,919 | Oct 21, 2019, 07:31 PM |
| Leber Laura | Chief Communication Officer | Oct 17, 2019 | Sale | $70.94 | 13,183 | 935,228 | 13,736 | Oct 21, 2019, 07:31 PM |
| Vaughn James J | Chief Commercial Officer | Oct 08, 2019 | Option Exercise | $33.21 | 4,500 | 149,445 | 20,917 | Oct 09, 2019, 05:12 PM |
| Vaughn James J | Chief Commercial Officer | Oct 08, 2019 | Sale | $67.75 | 4,500 | 304,875 | 16,417 | Oct 09, 2019, 05:12 PM |
| Popovits Kimberly J | President and CEO | Oct 08, 2019 | Sale | $67.74 | 10,000 | 677,364 | 68,268 | Oct 09, 2019, 05:11 PM |
| Cole G Bradley | CFO | Oct 07, 2019 | Option Exercise | $30.84 | 22,560 | 695,750 | 61,530 | Oct 09, 2019, 05:10 PM |
| Cole G Bradley | CFO | Oct 07, 2019 | Sale | $69.01 | 22,560 | 1,556,886 | 38,970 | Oct 09, 2019, 05:10 PM |
| FUCHS HENRY J | Director | Oct 01, 2019 | Option Exercise | $67.28 | 185 | 12,447 | 7,833 | Oct 03, 2019, 08:05 PM |
| Flannelly Barry P | Director | Oct 01, 2019 | Option Exercise | $67.28 | 185 | 12,447 | 397 | Oct 03, 2019, 08:01 PM |
| Cohen Fred E | Director | Oct 01, 2019 | Option Exercise | $67.28 | 185 | 12,447 | 69,120 | Oct 03, 2019, 08:00 PM |
| GRAHAM GINGER L | Director | Oct 01, 2019 | Option Exercise | $67.28 | 185 | 12,447 | 53,304 | Oct 03, 2019, 07:59 PM |
| BAKER BROS. ADVISORS LP | Director | Oct 01, 2019 | Option Exercise | $67.28 | 1,850 | 124,468 | 7,642,042 | Oct 03, 2019, 06:08 PM |
| Shak Steven | Chief Scientific Officer | Sep 17, 2019 | Sale | $71.47 | 25,000 | 1,786,692 | 58,795 | Sep 19, 2019, 04:58 PM |
| Popovits Kimberly J | President and CEO | Sep 09, 2019 | Sale | $72.53 | 10,000 | 725,285 | 81,351 | Sep 11, 2019, 04:16 PM |
| Cole G Bradley | CFO | Sep 09, 2019 | Option Exercise | $28.05 | 25,000 | 701,250 | 63,970 | Sep 11, 2019, 04:16 PM |
| Cole G Bradley | CFO | Sep 10, 2019 | Option Exercise | $28.05 | 18,112 | 508,042 | 57,082 | Sep 11, 2019, 04:16 PM |
| Cole G Bradley | CFO | Sep 10, 2019 | Sale | $71.79 | 18,112 | 1,300,277 | 43,779 | Sep 11, 2019, 04:16 PM |
| Cole G Bradley | CFO | Sep 09, 2019 | Sale | $72.52 | 25,000 | 1,813,071 | 46,439 | Sep 11, 2019, 04:16 PM |
| Vaughn James J | Chief Commercial Officer | Sep 09, 2019 | Option Exercise | $31.82 | 4,500 | 143,175 | 20,917 | Sep 11, 2019, 04:15 PM |
| Vaughn James J | Chief Commercial Officer | Sep 09, 2019 | Sale | $72.50 | 4,500 | 326,269 | 17,917 | Sep 11, 2019, 04:15 PM |
| Pla Frederic | COO | Aug 19, 2019 | Option Exercise | $27.48 | 1,251 | 34,377 | 33,142 | Aug 21, 2019, 07:40 PM |
| Pla Frederic | COO | Aug 19, 2019 | Sale | $75.00 | 1,251 | 93,825 | 31,891 | Aug 21, 2019, 07:40 PM |
| Radford Jason W. | Chief Legal Officer | Aug 15, 2019 | Sale | $74.13 | 2,181 | 161,669 | 29,395 | Aug 19, 2019, 07:57 PM |
| Radford Jason W. | Chief Legal Officer | Feb 19, 2019 | Sale | $83.16 | 3,508 | 291,709 | 31,787 | Aug 19, 2019, 07:55 PM |
| Cole G Bradley | CFO | Aug 12, 2019 | Option Exercise | $29.34 | 60,000 | 1,760,400 | 98,970 | Aug 14, 2019, 04:22 PM |
| Cole G Bradley | CFO | Aug 12, 2019 | Sale | $73.31 | 60,000 | 4,398,588 | 40,195 | Aug 14, 2019, 04:22 PM |
| Popovits Kimberly J | President and CEO | Aug 13, 2019 | Option Exercise | $29.34 | 15,000 | 440,100 | 123,468 | Aug 14, 2019, 04:21 PM |
| Popovits Kimberly J | President and CEO | Aug 12, 2019 | Option Exercise | $29.34 | 25,000 | 733,500 | 133,468 | Aug 14, 2019, 04:21 PM |
| Popovits Kimberly J | President and CEO | Aug 13, 2019 | Sale | $74.21 | 25,000 | 1,855,199 | 116,075 | Aug 14, 2019, 04:21 PM |
| Popovits Kimberly J | President and CEO | Aug 12, 2019 | Sale | $73.31 | 25,000 | 1,832,653 | 108,915 | Aug 14, 2019, 04:21 PM |
| Popovits Kimberly J | President and CEO | Aug 09, 2019 | Option Exercise | $29.34 | 25,000 | 733,500 | 133,468 | Aug 12, 2019, 07:08 PM |
| Popovits Kimberly J | President and CEO | Aug 08, 2019 | Option Exercise | $29.34 | 25,000 | 733,500 | 133,468 | Aug 12, 2019, 07:08 PM |
| Popovits Kimberly J | President and CEO | Aug 09, 2019 | Sale | $73.66 | 25,000 | 1,841,542 | 109,468 | Aug 12, 2019, 07:08 PM |
| Popovits Kimberly J | President and CEO | Aug 08, 2019 | Sale | $73.85 | 25,000 | 1,846,266 | 117,703 | Aug 12, 2019, 07:08 PM |
| Vaughn James J | Chief Commercial Officer | Aug 08, 2019 | Option Exercise | $31.63 | 4,500 | 142,345 | 20,917 | Aug 12, 2019, 07:08 PM |
| Vaughn James J | Chief Commercial Officer | Aug 08, 2019 | Sale | $73.74 | 4,500 | 331,825 | 20,520 | Aug 12, 2019, 07:08 PM |
| McEachron Kim | Chief People Officer | Aug 05, 2019 | Option Exercise | $30.16 | 12,103 | 365,005 | 48,575 | Aug 07, 2019, 04:54 PM |
| McEachron Kim | Chief People Officer | Aug 05, 2019 | Sale | $71.53 | 12,103 | 865,723 | 36,472 | Aug 07, 2019, 04:54 PM |
| Shak Steven | Chief Scientific Officer | Aug 06, 2019 | Sale | $72.37 | 25,000 | 1,809,331 | 91,935 | Aug 07, 2019, 04:53 PM |
| Shak Steven | Chief Scientific Officer | Aug 05, 2019 | Sale | $71.29 | 25,000 | 1,782,129 | 111,266 | Aug 07, 2019, 04:53 PM |
| Shak Steven | Chief Scientific Officer | Aug 02, 2019 | Sale | $72.43 | 25,000 | 1,810,858 | 133,795 | Aug 05, 2019, 04:35 PM |
| Shak Steven | Chief Scientific Officer | Aug 01, 2019 | Sale | $72.87 | 25,000 | 1,821,784 | 166,167 | Aug 05, 2019, 04:35 PM |
| Cole G Bradley | CFO | Jul 09, 2019 | Option Exercise | $17.18 | 6,471 | 111,172 | 50,441 | Jul 11, 2019, 06:13 PM |
| Cole G Bradley | CFO | Jul 09, 2019 | Sale | $57.08 | 6,471 | 369,386 | 49,003 | Jul 11, 2019, 06:13 PM |
| Shak Steven | Chief Scientific Officer | Jul 09, 2019 | Sale | $56.52 | 25,000 | 1,412,943 | 191,595 | Jul 10, 2019, 07:23 PM |
| Shak Steven | Chief Scientific Officer | Jul 08, 2019 | Sale | $57.10 | 25,000 | 1,427,384 | 212,843 | Jul 10, 2019, 07:23 PM |
| Vaughn James J | Chief Commercial Officer | Jul 08, 2019 | Option Exercise | $31.12 | 4,500 | 140,040 | 20,917 | Jul 09, 2019, 04:15 PM |
| Vaughn James J | Chief Commercial Officer | Jul 08, 2019 | Sale | $57.09 | 4,500 | 256,886 | 18,418 | Jul 09, 2019, 04:15 PM |
| McEachron Kim | Chief People Officer | Jul 05, 2019 | Option Exercise | $30.69 | 5,335 | 163,731 | 41,807 | Jul 09, 2019, 04:13 PM |
| McEachron Kim | Chief People Officer | Jul 05, 2019 | Sale | $60.01 | 5,335 | 320,151 | 36,472 | Jul 09, 2019, 04:13 PM |
| Cohen Fred E | Director | Jul 01, 2019 | Option Exercise | $58.86 | 212 | 12,478 | 68,935 | Jul 03, 2019, 05:50 PM |
| Flannelly Barry P | Director | Jul 01, 2019 | Option Exercise | $58.86 | 212 | 12,478 | 212 | Jul 03, 2019, 05:50 PM |
| FUCHS HENRY J | Director | Jul 01, 2019 | Option Exercise | $58.86 | 212 | 12,478 | 7,648 | Jul 03, 2019, 05:49 PM |
| GRAHAM GINGER L | Director | Jul 01, 2019 | Option Exercise | $58.86 | 212 | 12,478 | 53,119 | Jul 03, 2019, 05:48 PM |
| BAKER BROS. ADVISORS LP | Director | Jul 01, 2019 | Option Exercise | $58.86 | 2,544 | 149,740 | 7,641,672 | Jul 03, 2019, 01:16 PM |
| Shak Steven | Chief Scientific Officer | Jun 14, 2019 | Option Exercise | $31.12 | 10,550 | 328,316 | 244,345 | Jun 17, 2019, 06:26 PM |
| Shak Steven | Chief Scientific Officer | Jun 13, 2019 | Option Exercise | $31.12 | 25,000 | 778,000 | 258,795 | Jun 17, 2019, 06:26 PM |
| Shak Steven | Chief Scientific Officer | Jun 14, 2019 | Sale | $51.66 | 10,550 | 545,003 | 235,459 | Jun 17, 2019, 06:26 PM |
| Shak Steven | Chief Scientific Officer | Jun 13, 2019 | Sale | $51.94 | 25,000 | 1,298,572 | 234,604 | Jun 17, 2019, 06:26 PM |
| Shak Steven | Chief Scientific Officer | Jun 12, 2019 | Option Exercise | $30.95 | 25,000 | 773,768 | 258,479 | Jun 13, 2019, 07:33 PM |
| Shak Steven | Chief Scientific Officer | Jun 11, 2019 | Option Exercise | $30.89 | 25,000 | 772,278 | 258,479 | Jun 13, 2019, 07:33 PM |
| Shak Steven | Chief Scientific Officer | Jun 12, 2019 | Sale | $51.34 | 25,000 | 1,283,477 | 233,479 | Jun 13, 2019, 07:33 PM |
| Shak Steven | Chief Scientific Officer | Jun 11, 2019 | Sale | $51.43 | 25,000 | 1,285,702 | 237,181 | Jun 13, 2019, 07:33 PM |
| Cole G Bradley | CFO | Jun 11, 2019 | Option Exercise | $17.18 | 5,000 | 85,900 | 48,722 | Jun 13, 2019, 07:31 PM |
| Cole G Bradley | CFO | Jun 11, 2019 | Sale | $51.46 | 5,000 | 257,281 | 44,492 | Jun 13, 2019, 07:31 PM |
| Vaughn James J | Chief Commercial Officer | Jun 06, 2019 | Option Exercise | $31.12 | 4,500 | 140,040 | 24,920 | Jun 10, 2019, 07:37 PM |
| Vaughn James J | Chief Commercial Officer | Jun 06, 2019 | Sale | $52.47 | 8,745 | 458,829 | 22,320 | Jun 10, 2019, 07:37 PM |
| Cole G Bradley | CFO | May 14, 2019 | Option Exercise | $20.44 | 11,424 | 233,524 | 50,146 | May 15, 2019, 04:55 PM |
| Cole G Bradley | CFO | May 14, 2019 | Sale | $57.17 | 11,424 | 653,152 | 48,396 | May 15, 2019, 04:55 PM |
| Vaughn James J | Chief Commercial Officer | May 08, 2019 | Option Exercise | $31.12 | 4,500 | 140,040 | 27,664 | May 10, 2019, 08:10 PM |
| Vaughn James J | Chief Commercial Officer | May 08, 2019 | Sale | $58.08 | 7,244 | 420,730 | 27,064 | May 10, 2019, 08:10 PM |
| Shak Steven | Chief Scientific Officer | May 08, 2019 | Sale | $57.90 | 25,000 | 1,447,616 | 255,379 | May 10, 2019, 08:07 PM |
| BAKER BROS. ADVISORS LP | Director | Apr 12, 2019 | Sale | $65.32 | 11,204 | 731,889 | 7,639,338 | Apr 12, 2019, 05:02 PM |
| BAKER BROS. ADVISORS LP | Director | Apr 12, 2019 | Sale | $65.30 | 287,465 | 18,770,152 | 7,712,345 | Apr 12, 2019, 05:01 PM |
| BAKER BROS. ADVISORS LP | Director | Apr 11, 2019 | Sale | $66.90 | 202,281 | 13,533,252 | 7,991,484 | Apr 12, 2019, 05:01 PM |
| Cole G Bradley | CFO | Apr 09, 2019 | Option Exercise | $21.05 | 15,000 | 315,700 | 58,722 | Apr 11, 2019, 06:11 PM |
| Cole G Bradley | CFO | Apr 09, 2019 | Sale | $67.61 | 15,000 | 1,014,120 | 53,826 | Apr 11, 2019, 06:11 PM |
| Vaughn James J | Chief Commercial Officer | Apr 08, 2019 | Option Exercise | $31.12 | 3,000 | 93,360 | 26,164 | Apr 10, 2019, 07:48 PM |
| Vaughn James J | Chief Commercial Officer | Apr 08, 2019 | Sale | $67.73 | 3,000 | 203,179 | 25,202 | Apr 10, 2019, 07:48 PM |
| Popovits Kimberly J | President and CEO | Apr 08, 2019 | Sale | $66.93 | 10,000 | 669,321 | 111,416 | Apr 10, 2019, 07:45 PM |
| BAKER BROS. ADVISORS LP | Director | Apr 10, 2019 | Sale | $69.12 | 13,146 | 908,684 | 8,052,102 | Apr 10, 2019, 05:24 PM |
| BAKER BROS. ADVISORS LP | Director | Apr 09, 2019 | Sale | $67.70 | 21,063 | 1,425,885 | 8,181,095 | Apr 10, 2019, 05:24 PM |
| BAKER BROS. ADVISORS LP | Director | Apr 08, 2019 | Sale | $67.90 | 22,648 | 1,537,720 | 8,182,908 | Apr 10, 2019, 05:24 PM |
| BAKER BROS. ADVISORS LP | Director | Apr 10, 2019 | Sale | $68.70 | 124,542 | 8,556,110 | 8,062,934 | Apr 10, 2019, 05:24 PM |
| BAKER BROS. ADVISORS LP | Director | Apr 05, 2019 | Sale | $68.69 | 77,648 | 5,333,397 | 8,244,432 | Apr 05, 2019, 05:51 PM |
| BAKER BROS. ADVISORS LP | Director | Apr 04, 2019 | Sale | $66.64 | 81,053 | 5,401,340 | 8,265,548 | Apr 05, 2019, 05:51 PM |
| BAKER BROS. ADVISORS LP | Director | Apr 03, 2019 | Sale | $68.90 | 97,269 | 6,701,718 | 8,332,332 | Apr 05, 2019, 05:51 PM |
| FUCHS HENRY J | Director | Apr 01, 2019 | Option Exercise | $66.84 | 149 | 9,959 | 6,481 | Apr 03, 2019, 06:01 PM |
| Cohen Fred E | Director | Apr 01, 2019 | Option Exercise | $66.84 | 149 | 9,959 | 67,768 | Apr 03, 2019, 06:00 PM |
| GRAHAM GINGER L | Director | Apr 01, 2019 | Option Exercise | $66.84 | 149 | 9,959 | 51,952 | Apr 03, 2019, 06:00 PM |
| BAKER BROS. ADVISORS LP | Director | Apr 01, 2019 | Option Exercise | $66.84 | 1,788 | 119,510 | 8,412,478 | Apr 03, 2019, 05:35 PM |
| Shak Steven | Chief Scientific Officer | Apr 01, 2019 | Sale | $67.76 | 25,000 | 1,694,059 | 272,958 | Apr 01, 2019, 06:58 PM |
| Shak Steven | Chief Scientific Officer | Mar 29, 2019 | Sale | $69.38 | 25,000 | 1,734,470 | 294,107 | Apr 01, 2019, 06:58 PM |
| Shak Steven | Chief Scientific Officer | Mar 28, 2019 | Sale | $68.53 | 25,000 | 1,713,259 | 318,859 | Apr 01, 2019, 06:58 PM |
| BAKER BROS. ADVISORS LP | Director | Mar 21, 2019 | Sale | $74.71 | 56,651 | 4,232,164 | 8,412,180 | Mar 25, 2019, 05:05 PM |
| Pla Frederic | COO | Mar 19, 2019 | Option Exercise | $28.77 | 4,700 | 135,234 | 36,275 | Mar 19, 2019, 06:42 PM |
| Pla Frederic | COO | Mar 18, 2019 | Option Exercise | $27.48 | 1,000 | 27,480 | 32,575 | Mar 19, 2019, 06:42 PM |
| Pla Frederic | COO | Mar 19, 2019 | Sale | $75.00 | 4,700 | 352,500 | 31,575 | Mar 19, 2019, 06:42 PM |
| Pla Frederic | COO | Mar 18, 2019 | Sale | $75.12 | 1,000 | 75,122 | 31,575 | Mar 19, 2019, 06:42 PM |
| BAKER BROS. ADVISORS LP | Director | Mar 19, 2019 | Sale | $74.34 | 50,100 | 3,724,594 | 8,458,858 | Mar 19, 2019, 05:48 PM |
| BAKER BROS. ADVISORS LP | Director | Mar 19, 2019 | Sale | $74.34 | 50,100 | 3,724,594 | 8,458,858 | Mar 19, 2019, 05:37 PM |
| BAKER BROS. ADVISORS LP | Director | Mar 19, 2019 | Sale | $74.63 | 105,126 | 7,845,648 | 8,500,139 | Mar 19, 2019, 05:31 PM |
| BAKER BROS. ADVISORS LP | Director | Mar 18, 2019 | Sale | $74.19 | 109,533 | 8,125,969 | 8,586,759 | Mar 19, 2019, 05:31 PM |
| BAKER BROS. ADVISORS LP | Director | Mar 15, 2019 | Sale | $74.64 | 55,347 | 4,131,088 | 8,719,547 | Mar 19, 2019, 05:31 PM |
| BAKER BROS. ADVISORS LP | Director | Mar 14, 2019 | Sale | $76.49 | 65,094 | 4,978,787 | 8,724,263 | Mar 14, 2019, 05:03 PM |
| BAKER BROS. ADVISORS LP | Director | Mar 13, 2019 | Sale | $75.92 | 80,253 | 6,092,923 | 8,839,544 | Mar 14, 2019, 05:03 PM |
| BAKER BROS. ADVISORS LP | Director | Mar 12, 2019 | Sale | $75.63 | 74,180 | 5,610,248 | 8,842,376 | Mar 14, 2019, 05:03 PM |
| Cole G Bradley | CFO | Mar 12, 2019 | Option Exercise | $21.05 | 15,000 | 315,700 | 58,722 | Mar 14, 2019, 04:06 PM |
| Cole G Bradley | CFO | Mar 12, 2019 | Sale | $75.15 | 15,000 | 1,127,273 | 54,722 | Mar 14, 2019, 04:06 PM |
| Popovits Kimberly J | President and CEO | Mar 08, 2019 | Sale | $73.22 | 10,000 | 732,237 | 126,799 | Mar 12, 2019, 09:47 PM |
| Vaughn James J | Chief Commercial Officer | Mar 07, 2019 | Option Exercise | $31.12 | 3,000 | 93,360 | 25,790 | Mar 11, 2019, 06:42 PM |
| Vaughn James J | Chief Commercial Officer | Mar 07, 2019 | Sale | $73.87 | 3,000 | 221,596 | 25,190 | Mar 11, 2019, 06:42 PM |
| BAKER BROS. ADVISORS LP | Director | Mar 07, 2019 | Sale | $73.72 | 2,000 | 147,445 | 8,962,604 | Mar 11, 2019, 04:59 PM |
| BAKER BROS. ADVISORS LP | Director | Mar 11, 2019 | Sale | $75.00 | 49,035 | 3,677,484 | 8,906,794 | Mar 11, 2019, 04:59 PM |
| BAKER BROS. ADVISORS LP | Director | Mar 08, 2019 | Sale | $73.55 | 22,700 | 1,669,519 | 8,943,901 | Mar 11, 2019, 04:59 PM |
| BAKER BROS. ADVISORS LP | Director | Mar 04, 2019 | Sale | $76.49 | 27,811 | 2,127,250 | 8,972,737 | Mar 05, 2019, 06:30 PM |
| BAKER BROS. ADVISORS LP | Director | Mar 01, 2019 | Sale | $77.20 | 79,276 | 6,120,387 | 9,054,063 | Mar 05, 2019, 06:30 PM |
| BAKER BROS. ADVISORS LP | Director | Mar 05, 2019 | Sale | $77.04 | 10,300 | 793,504 | 8,964,251 | Mar 05, 2019, 06:30 PM |
| Shak Steven | Chief Scientific Officer | Mar 04, 2019 | Option Exercise | $28.05 | 7,500 | 210,375 | 342,979 | Mar 05, 2019, 12:00 AM |
| Shak Steven | Chief Scientific Officer | Mar 01, 2019 | Option Exercise | $28.05 | 25,000 | 701,250 | 360,479 | Mar 05, 2019, 12:00 AM |
| Shak Steven | Chief Scientific Officer | Mar 04, 2019 | Sale | $75.89 | 7,500 | 569,202 | 341,061 | Mar 05, 2019, 12:00 AM |
| Shak Steven | Chief Scientific Officer | Mar 01, 2019 | Sale | $77.22 | 25,000 | 1,930,424 | 342,901 | Mar 05, 2019, 12:00 AM |
| Shak Steven | Chief Scientific Officer | Feb 28, 2019 | Option Exercise | $19.35 | 25,000 | 483,850 | 360,479 | Mar 01, 2019, 07:05 PM |
| Shak Steven | Chief Scientific Officer | Feb 27, 2019 | Option Exercise | $17.18 | 25,000 | 429,500 | 360,479 | Mar 01, 2019, 07:05 PM |
| Shak Steven | Chief Scientific Officer | Feb 27, 2019 | Sale | $76.59 | 25,000 | 1,914,824 | 337,672 | Mar 01, 2019, 07:05 PM |
| Shak Steven | Chief Scientific Officer | Feb 28, 2019 | Sale | $76.40 | 25,000 | 1,909,972 | 355,177 | Mar 01, 2019, 07:05 PM |
| BAKER BROS. ADVISORS LP | Director | Feb 28, 2019 | Sale | $76.20 | 600 | 45,719 | 9,060,972 | Feb 28, 2019, 06:22 PM |
| BAKER BROS. ADVISORS LP | Director | Feb 26, 2019 | Option Exercise | $17.59 | 16,500 | 290,235 | 9,100,815 | Feb 28, 2019, 06:21 PM |
| BAKER BROS. ADVISORS LP | Director | Feb 27, 2019 | Sale | $76.65 | 39,109 | 2,997,792 | 9,062,207 | Feb 28, 2019, 06:21 PM |
| BAKER BROS. ADVISORS LP | Director | Feb 26, 2019 | Sale | $78.11 | 8,650 | 675,614 | 9,094,309 | Feb 28, 2019, 06:21 PM |
| FUCHS HENRY J | Director | Feb 25, 2019 | Option Exercise | $27.75 | 3,521 | 97,708 | 9,853 | Feb 26, 2019, 04:51 PM |
| FUCHS HENRY J | Director | Feb 22, 2019 | Option Exercise | $32.22 | 26,479 | 853,192 | 32,811 | Feb 26, 2019, 04:51 PM |
| FUCHS HENRY J | Director | Feb 25, 2019 | Sale | $79.02 | 3,521 | 278,226 | 6,853 | Feb 26, 2019, 04:51 PM |
| FUCHS HENRY J | Director | Feb 22, 2019 | Sale | $81.89 | 26,479 | 2,168,403 | 21,332 | Feb 26, 2019, 04:51 PM |
| Cohen Fred E | Director | Feb 22, 2019 | Option Exercise | $26.01 | 10,000 | 260,100 | 77,619 | Feb 26, 2019, 04:49 PM |
| Cohen Fred E | Director | Feb 22, 2019 | Sale | $78.86 | 10,000 | 788,559 | 68,312 | Feb 26, 2019, 04:49 PM |
| Pla Frederic | COO | Feb 21, 2019 | Sale | $86.51 | 783 | 67,736 | 31,575 | Feb 25, 2019, 08:19 PM |
| Vaughn James J | Chief Commercial Officer | Feb 15, 2019 | Option Exercise | $83.34 | 2,904 | 242,019 | 21,595 | Feb 25, 2019, 08:15 PM |
| Shak Steven | Chief Scientific Officer | Feb 15, 2019 | Option Exercise | $83.34 | 3,492 | 291,023 | 335,479 | Feb 25, 2019, 08:15 PM |
| Radford Jason W. | Chief Legal Officer | Feb 15, 2019 | Option Exercise | $83.34 | 3,720 | 310,025 | 34,676 | Feb 25, 2019, 08:13 PM |
| Popovits Kimberly J | President and CEO | Feb 15, 2019 | Option Exercise | $83.34 | 12,890 | 1,074,253 | 55,138 | Feb 25, 2019, 08:12 PM |
| Pla Frederic | COO | Feb 15, 2019 | Option Exercise | $83.34 | 3,320 | 276,689 | 36,358 | Feb 25, 2019, 08:03 PM |
| McEachron Kim | Chief People Officer | Feb 15, 2019 | Option Exercise | $83.34 | 2,489 | 207,433 | 36,077 | Feb 25, 2019, 07:58 PM |
| Leber Laura | Chief Communication Officer | Feb 15, 2019 | Option Exercise | $83.34 | 2,106 | 175,514 | 17,512 | Feb 25, 2019, 07:57 PM |
| Cole G Bradley | CFO | Feb 15, 2019 | Option Exercise | $83.34 | 4,345 | 362,112 | 43,722 | Feb 25, 2019, 07:56 PM |
| Leber Laura | Chief Communication Officer | Feb 21, 2019 | Option Exercise | $22.98 | 1,817 | 41,755 | 22,666 | Feb 22, 2019, 08:45 PM |
| Leber Laura | Chief Communication Officer | Feb 20, 2019 | Option Exercise | $17.18 | 18,750 | 322,125 | 39,599 | Feb 22, 2019, 08:45 PM |
| Leber Laura | Chief Communication Officer | Feb 21, 2019 | Sale | $80.24 | 5,634 | 452,076 | 21,599 | Feb 22, 2019, 08:45 PM |
| Leber Laura | Chief Communication Officer | Feb 20, 2019 | Sale | $82.87 | 18,750 | 1,553,824 | 24,120 | Feb 22, 2019, 08:45 PM |
| Radford Jason W. | Chief Legal Officer | Feb 19, 2019 | Sale | $83.16 | 3,508 | 291,709 | 35,507 | Feb 21, 2019, 07:25 PM |
| Vaughn James J | Chief Commercial Officer | Feb 19, 2019 | Option Exercise | $30.23 | 1,195 | 36,130 | 25,320 | Feb 21, 2019, 07:24 PM |
| Pla Frederic | COO | Feb 19, 2019 | Option Exercise | $28.55 | 5,700 | 162,714 | 45,378 | Feb 21, 2019, 07:24 PM |
| Pla Frederic | COO | Feb 19, 2019 | Sale | $83.16 | 9,700 | 806,661 | 39,294 | Feb 21, 2019, 07:24 PM |
| Popovits Kimberly J | President and CEO | Feb 14, 2019 | Option Exercise | $17.18 | 47,900 | 822,922 | 164,882 | Feb 19, 2019, 07:38 PM |
| Popovits Kimberly J | President and CEO | Feb 14, 2019 | Sale | $81.70 | 47,900 | 3,913,615 | 130,882 | Feb 19, 2019, 07:38 PM |
| Cole G Bradley | CFO | Feb 12, 2019 | Option Exercise | $21.05 | 15,000 | 315,700 | 58,067 | Feb 14, 2019, 05:50 PM |
| Cole G Bradley | CFO | Feb 12, 2019 | Sale | $80.87 | 15,000 | 1,213,024 | 52,132 | Feb 14, 2019, 05:50 PM |
| Vaughn James J | Chief Commercial Officer | Feb 07, 2019 | Option Exercise | $31.12 | 3,000 | 93,360 | 27,125 | Feb 11, 2019, 07:53 PM |
| Vaughn James J | Chief Commercial Officer | Feb 07, 2019 | Sale | $77.42 | 3,000 | 232,272 | 25,075 | Feb 11, 2019, 07:53 PM |
| Shak Steven | Chief Scientific Officer | Feb 01, 2019 | Option Exercise | $22.98 | 25,000 | 574,500 | 364,671 | Feb 05, 2019, 05:55 PM |
| Shak Steven | Chief Scientific Officer | Feb 04, 2019 | Option Exercise | $20.66 | 25,000 | 516,500 | 364,671 | Feb 05, 2019, 05:55 PM |
| Shak Steven | Chief Scientific Officer | Feb 04, 2019 | Sale | $76.73 | 25,000 | 1,918,308 | 362,479 | Feb 05, 2019, 05:55 PM |
| Shak Steven | Chief Scientific Officer | Feb 01, 2019 | Sale | $75.86 | 25,000 | 1,896,384 | 359,331 | Feb 05, 2019, 05:55 PM |
| Shak Steven | Chief Scientific Officer | Jan 31, 2019 | Option Exercise | $29.34 | 25,000 | 733,500 | 364,671 | Feb 01, 2019, 07:08 PM |
| Shak Steven | Chief Scientific Officer | Jan 30, 2019 | Option Exercise | $29.34 | 25,000 | 733,500 | 364,671 | Feb 01, 2019, 07:08 PM |
| Shak Steven | Chief Scientific Officer | Jan 31, 2019 | Sale | $74.98 | 25,000 | 1,874,571 | 362,863 | Feb 01, 2019, 07:08 PM |
| Shak Steven | Chief Scientific Officer | Jan 30, 2019 | Sale | $73.49 | 25,000 | 1,837,229 | 361,570 | Feb 01, 2019, 07:08 PM |
| BAKER BROS. ADVISORS LP | Director | Jan 28, 2019 | Sale | $71.07 | 46,477 | 3,302,980 | 9,106,199 | Jan 30, 2019, 04:00 PM |
| BAKER BROS. ADVISORS LP | Director | Jan 25, 2019 | Sale | $72.20 | 91,916 | 6,636,648 | 9,130,859 | Jan 25, 2019, 05:19 PM |
| BAKER BROS. ADVISORS LP | Director | Jan 24, 2019 | Sale | $72.02 | 79,403 | 5,718,588 | 9,206,595 | Jan 25, 2019, 05:19 PM |
| BAKER BROS. ADVISORS LP | Director | Jan 23, 2019 | Sale | $70.67 | 37,512 | 2,651,092 | 9,273,669 | Jan 25, 2019, 05:19 PM |
| Radford Jason W. | Chief Legal Officer | Jan 22, 2019 | Sale | $71.44 | 2,963 | 211,683 | 32,751 | Jan 24, 2019, 06:30 PM |
| Vaughn James J | Chief Commercial Officer | Jan 17, 2019 | Option Exercise | $28.74 | 2,222 | 63,854 | 19,985 | Jan 22, 2019, 07:33 PM |
| BAKER BROS. ADVISORS LP | Director | Jan 22, 2019 | Sale | $71.00 | 51,606 | 3,664,031 | 9,302,929 | Jan 22, 2019, 05:27 PM |
| BAKER BROS. ADVISORS LP | Director | Jan 18, 2019 | Sale | $72.73 | 177,142 | 12,884,344 | 9,369,592 | Jan 22, 2019, 05:26 PM |
| BAKER BROS. ADVISORS LP | Director | Jan 17, 2019 | Sale | $70.79 | 181,747 | 12,866,124 | 9,501,955 | Jan 22, 2019, 05:26 PM |
| BAKER BROS. ADVISORS LP | Director | Jan 22, 2019 | Sale | $71.61 | 12,800 | 916,641 | 9,345,450 | Jan 22, 2019, 05:26 PM |
| BAKER BROS. ADVISORS LP | Director | Jan 14, 2019 | Sale | $70.07 | 600 | 42,043 | 9,651,709 | Jan 14, 2019, 05:11 PM |
| BAKER BROS. ADVISORS LP | Director | Jan 11, 2019 | Sale | $70.22 | 28,474 | 1,999,533 | 9,652,202 | Jan 14, 2019, 05:11 PM |
| BAKER BROS. ADVISORS LP | Director | Jan 10, 2019 | Sale | $70.28 | 10,185 | 715,780 | 9,675,664 | Jan 14, 2019, 05:11 PM |
| Cole G Bradley | CFO | Jan 08, 2019 | Option Exercise | $21.05 | 15,000 | 315,700 | 54,047 | Jan 09, 2019, 07:43 PM |
| Cole G Bradley | CFO | Jan 08, 2019 | Sale | $67.03 | 15,000 | 1,005,401 | 51,947 | Jan 09, 2019, 07:43 PM |
| Vaughn James J | Chief Commercial Officer | Jan 08, 2019 | Option Exercise | $31.12 | 3,000 | 93,360 | 20,763 | Jan 09, 2019, 07:42 PM |
| Vaughn James J | Chief Commercial Officer | Jan 08, 2019 | Sale | $67.06 | 3,000 | 201,181 | 19,963 | Jan 09, 2019, 07:42 PM |
| Cohen Fred E | Director | Jan 01, 2019 | Option Exercise | $64.41 | 155 | 9,984 | 67,619 | Jan 03, 2019, 07:13 PM |
| FUCHS HENRY J | Director | Jan 01, 2019 | Option Exercise | $64.41 | 155 | 9,984 | 6,332 | Jan 03, 2019, 07:13 PM |
| GRAHAM GINGER L | Director | Jan 01, 2019 | Option Exercise | $64.41 | 155 | 9,984 | 51,803 | Jan 03, 2019, 07:12 PM |
| BAKER BROS. ADVISORS LP | Director | Jan 01, 2019 | Option Exercise | $64.41 | 1,860 | 119,803 | 9,684,056 | Jan 03, 2019, 12:00 AM |
| Popovits Kimberly J | President and CEO | Dec 18, 2018 | Sale | $66.69 | 25,000 | 1,667,285 | 137,912 | Dec 19, 2018, 05:59 PM |
| Popovits Kimberly J | President and CEO | Dec 17, 2018 | Sale | $66.89 | 25,000 | 1,672,242 | 159,275 | Dec 19, 2018, 05:59 PM |
| GRAHAM GINGER L | Director | Dec 11, 2018 | Option Exercise | $19.25 | 24,750 | 476,438 | 51,648 | Dec 13, 2018, 06:25 PM |
| Cole G Bradley | CFO | Dec 11, 2018 | Option Exercise | $21.05 | 15,000 | 315,700 | 59,047 | Dec 13, 2018, 06:24 PM |
| Cole G Bradley | CFO | Dec 11, 2018 | Sale | $71.95 | 15,000 | 1,079,219 | 56,518 | Dec 13, 2018, 06:24 PM |
| BAKER BROS. ADVISORS LP | Director | Dec 10, 2018 | Sale | $73.83 | 9,366 | 691,483 | 9,746,410 | Dec 12, 2018, 05:57 PM |
| BAKER BROS. ADVISORS LP | Director | Dec 12, 2018 | Sale | $73.09 | 18,500 | 1,352,087 | 9,683,746 | Dec 12, 2018, 05:57 PM |
| BAKER BROS. ADVISORS LP | Director | Dec 11, 2018 | Sale | $74.07 | 57,554 | 4,262,823 | 9,711,616 | Dec 12, 2018, 05:57 PM |
| BAKER BROS. ADVISORS LP | Director | Dec 07, 2018 | Sale | $76.15 | 102,455 | 7,802,358 | 9,754,128 | Dec 07, 2018, 05:16 PM |
| BAKER BROS. ADVISORS LP | Director | Dec 06, 2018 | Sale | $75.46 | 92,679 | 6,993,622 | 9,838,546 | Dec 07, 2018, 05:16 PM |
| BAKER BROS. ADVISORS LP | Director | Dec 04, 2018 | Sale | $75.62 | 32,776 | 2,478,447 | 9,941,545 | Dec 07, 2018, 05:15 PM |
| Vaughn James J | Chief Commercial Officer | Dec 06, 2018 | Option Exercise | $31.12 | 3,000 | 93,360 | 20,763 | Dec 07, 2018, 05:03 PM |
| Vaughn James J | Chief Commercial Officer | Dec 06, 2018 | Sale | $75.30 | 3,000 | 225,888 | 20,463 | Dec 07, 2018, 05:03 PM |
| Shak Steven | Chief Scientific Officer | Dec 03, 2018 | Option Exercise | $17.33 | 1,500 | 25,995 | 338,241 | Dec 06, 2018, 07:47 PM |
| Shak Steven | Chief Scientific Officer | Dec 03, 2018 | Sale | $78.18 | 1,500 | 117,273 | 338,128 | Dec 06, 2018, 07:47 PM |
| BAKER BROS. ADVISORS LP | Director | Dec 03, 2018 | Sale | $78.49 | 202,134 | 15,865,833 | 10,063,808 | Dec 03, 2018, 05:40 PM |
| BAKER BROS. ADVISORS LP | Director | Nov 30, 2018 | Sale | $79.20 | 204,757 | 16,217,023 | 10,237,588 | Dec 03, 2018, 05:39 PM |
| BAKER BROS. ADVISORS LP | Director | Nov 29, 2018 | Sale | $77.95 | 51,278 | 3,997,192 | 10,307,436 | Dec 03, 2018, 05:39 PM |
| BAKER BROS. ADVISORS LP | Director | Nov 28, 2018 | Sale | $75.61 | 250,392 | 18,932,284 | 10,468,980 | Nov 28, 2018, 05:44 PM |
| BAKER BROS. ADVISORS LP | Director | Nov 26, 2018 | Sale | $74.28 | 39,675 | 2,947,113 | 10,648,158 | Nov 28, 2018, 05:42 PM |
| BAKER BROS. ADVISORS LP | Director | Nov 27, 2018 | Sale | $74.09 | 138,610 | 10,269,089 | 10,562,396 | Nov 28, 2018, 05:42 PM |
| BAKER BROS. ADVISORS LP | Director | Nov 16, 2018 | Sale | $76.65 | 87,395 | 6,699,000 | 10,728,010 | Nov 20, 2018, 05:06 PM |
| Popovits Kimberly J | President and CEO | Nov 16, 2018 | Sale | $76.72 | 10,000 | 767,171 | 171,127 | Nov 20, 2018, 04:45 PM |
| Popovits Kimberly J | President and CEO | Nov 15, 2018 | Option Exercise | $22.98 | 25,000 | 574,500 | 201,982 | Nov 19, 2018, 09:27 PM |
| Popovits Kimberly J | President and CEO | Nov 16, 2018 | Option Exercise | $22.98 | 15,000 | 344,700 | 191,982 | Nov 19, 2018, 09:27 PM |
| Popovits Kimberly J | President and CEO | Nov 16, 2018 | Sale | $76.72 | 15,000 | 1,150,793 | 183,321 | Nov 19, 2018, 09:27 PM |
| Popovits Kimberly J | President and CEO | Nov 15, 2018 | Sale | $77.18 | 25,000 | 1,929,560 | 196,982 | Nov 19, 2018, 09:27 PM |
| Cole G Bradley | CFO | Nov 13, 2018 | Option Exercise | $19.60 | 8,576 | 168,076 | 53,948 | Nov 15, 2018, 04:04 PM |
| Cole G Bradley | CFO | Nov 13, 2018 | Sale | $79.18 | 8,576 | 679,027 | 51,131 | Nov 15, 2018, 04:04 PM |
| Shak Steven | Chief Scientific Officer | Nov 09, 2018 | Option Exercise | $17.33 | 5,500 | 95,315 | 342,241 | Nov 14, 2018, 08:13 PM |
| Shak Steven | Chief Scientific Officer | Nov 09, 2018 | Sale | $83.21 | 5,500 | 457,646 | 339,484 | Nov 14, 2018, 08:13 PM |
| BAKER BROS. ADVISORS LP | Director | Nov 13, 2018 | Sale | $79.69 | 114,858 | 9,153,058 | 10,786,282 | Nov 13, 2018, 06:35 PM |
| BAKER BROS. ADVISORS LP | Director | Nov 13, 2018 | Sale | $78.50 | 138,712 | 10,889,359 | 10,938,575 | Nov 13, 2018, 06:33 PM |
| BAKER BROS. ADVISORS LP | Director | Nov 12, 2018 | Sale | $81.07 | 65,588 | 5,317,265 | 11,000,100 | Nov 13, 2018, 06:33 PM |
| BAKER BROS. ADVISORS LP | Director | Nov 12, 2018 | Sale | $80.38 | 14,415 | 1,158,724 | 11,007,633 | Nov 13, 2018, 06:32 PM |
| BAKER BROS. ADVISORS LP | Director | Nov 09, 2018 | Sale | $82.51 | 169,344 | 13,972,201 | 11,150,887 | Nov 13, 2018, 06:32 PM |
| BAKER BROS. ADVISORS LP | Director | Nov 09, 2018 | Sale | $83.71 | 107,738 | 9,018,337 | 11,243,695 | Nov 13, 2018, 06:29 PM |
| Vaughn James J | Chief Commercial Officer | Nov 08, 2018 | Option Exercise | $31.12 | 3,000 | 93,360 | 20,542 | Nov 13, 2018, 06:29 PM |
| Vaughn James J | Chief Commercial Officer | Nov 08, 2018 | Sale | $85.18 | 3,000 | 255,545 | 19,442 | Nov 13, 2018, 06:29 PM |
| Cohen Fred E | Director | Nov 08, 2018 | Option Exercise | $27.75 | 10,000 | 277,500 | 77,464 | Nov 13, 2018, 06:27 PM |
| Cohen Fred E | Director | Nov 08, 2018 | Sale | $87.93 | 10,000 | 879,262 | 76,628 | Nov 13, 2018, 06:27 PM |
| BAKER BROS. ADVISORS LP | Director | Nov 08, 2018 | Sale | $86.50 | 76,273 | 6,597,504 | 11,280,104 | Nov 13, 2018, 06:26 PM |
| BAKER BROS. ADVISORS LP | Director | Nov 08, 2018 | Sale | $85.58 | 72,745 | 6,225,158 | 11,354,802 | Nov 13, 2018, 06:22 PM |
| Pla Frederic | COO | Nov 07, 2018 | Option Exercise | $27.08 | 43,500 | 1,177,796 | 79,038 | Nov 09, 2018, 04:02 PM |
| Pla Frederic | COO | Nov 07, 2018 | Sale | $84.91 | 43,500 | 3,693,589 | 76,938 | Nov 09, 2018, 04:02 PM |
| Popovits Kimberly J | President and CEO | Oct 16, 2018 | Option Exercise | $22.98 | 25,000 | 574,500 | 201,982 | Oct 17, 2018, 05:52 PM |
| Popovits Kimberly J | President and CEO | Oct 15, 2018 | Option Exercise | $22.98 | 25,000 | 574,500 | 201,982 | Oct 17, 2018, 05:52 PM |
| Popovits Kimberly J | President and CEO | Oct 16, 2018 | Sale | $66.26 | 25,000 | 1,656,524 | 199,187 | Oct 17, 2018, 05:52 PM |
| Popovits Kimberly J | President and CEO | Oct 15, 2018 | Sale | $64.31 | 25,000 | 1,607,641 | 178,262 | Oct 17, 2018, 05:52 PM |
| Shak Steven | Chief Scientific Officer | Oct 09, 2018 | Option Exercise | $17.33 | 5,500 | 95,315 | 342,241 | Oct 11, 2018, 07:59 PM |
| Shak Steven | Chief Scientific Officer | Oct 09, 2018 | Sale | $64.35 | 5,500 | 353,950 | 337,841 | Oct 11, 2018, 07:59 PM |
| Cole G Bradley | CFO | Oct 10, 2018 | Option Exercise | $17.18 | 5,000 | 85,900 | 50,372 | Oct 11, 2018, 07:58 PM |
| Cole G Bradley | CFO | Oct 10, 2018 | Sale | $63.19 | 5,000 | 315,955 | 48,021 | Oct 11, 2018, 07:58 PM |
| Pla Frederic | COO | Oct 08, 2018 | Option Exercise | $27.00 | 1,500 | 40,500 | 37,038 | Oct 10, 2018, 06:04 PM |
| Pla Frederic | COO | Oct 08, 2018 | Sale | $65.43 | 1,500 | 98,148 | 35,938 | Oct 10, 2018, 06:04 PM |
| Vaughn James J | Chief Commercial Officer | Oct 08, 2018 | Option Exercise | $30.41 | 25,000 | 760,154 | 42,542 | Oct 10, 2018, 06:02 PM |
| Vaughn James J | Chief Commercial Officer | Oct 09, 2018 | Option Exercise | $27.50 | 25,000 | 687,560 | 42,542 | Oct 10, 2018, 06:02 PM |
| Vaughn James J | Chief Commercial Officer | Oct 09, 2018 | Sale | $64.37 | 25,000 | 1,609,325 | 23,272 | Oct 10, 2018, 06:02 PM |
| Vaughn James J | Chief Commercial Officer | Oct 08, 2018 | Sale | $65.34 | 25,000 | 1,633,518 | 26,327 | Oct 10, 2018, 06:02 PM |
| FUCHS HENRY J | Director | Oct 01, 2018 | Option Exercise | $70.18 | 142 | 9,966 | 6,177 | Oct 03, 2018, 08:32 PM |
| Cohen Fred E | Director | Oct 01, 2018 | Option Exercise | $70.18 | 142 | 9,966 | 67,464 | Oct 03, 2018, 08:13 PM |
| GRAHAM GINGER L | Director | Oct 01, 2018 | Option Exercise | $70.18 | 142 | 9,966 | 26,898 | Oct 03, 2018, 08:12 PM |
| BAKER BROS. ADVISORS LP | Director | Oct 01, 2018 | Option Exercise | $70.18 | 1,704 | 119,587 | 11,370,600 | Oct 03, 2018, 07:43 PM |
| Cole G Bradley | COO | Sep 11, 2018 | Option Exercise | $17.18 | 5,000 | 85,900 | 50,372 | Sep 13, 2018, 06:48 PM |
| Cole G Bradley | COO | Sep 11, 2018 | Sale | $64.01 | 5,000 | 320,074 | 46,972 | Sep 13, 2018, 06:48 PM |
| Pla Frederic | Chief Bus & Prod Dev Officer | Sep 10, 2018 | Option Exercise | $27.00 | 1,500 | 40,500 | 37,038 | Sep 11, 2018, 07:40 PM |
| Pla Frederic | Chief Bus & Prod Dev Officer | Sep 10, 2018 | Sale | $62.98 | 1,500 | 94,467 | 35,938 | Sep 11, 2018, 07:40 PM |
| Shak Steven | Chief Scientific Officer | Sep 10, 2018 | Option Exercise | $27.33 | 5,500 | 150,315 | 342,241 | Sep 11, 2018, 07:38 PM |
| Shak Steven | Chief Scientific Officer | Sep 10, 2018 | Sale | $63.05 | 5,500 | 346,794 | 338,604 | Sep 11, 2018, 07:38 PM |
| Cohen Fred E | Director | Sep 06, 2018 | Option Exercise | $34.44 | 8,250 | 284,130 | 75,572 | Sep 10, 2018, 05:02 PM |
| Cohen Fred E | Director | Sep 06, 2018 | Sale | $61.51 | 8,250 | 507,453 | 67,322 | Sep 10, 2018, 05:02 PM |
| Popovits Kimberly J | President and CEO | Aug 14, 2018 | Sale | $52.60 | 60,000 | 3,156,203 | 228,532 | Aug 16, 2018, 04:23 PM |
| Shak Steven | Chief Scientific Officer | Aug 09, 2018 | Option Exercise | $17.33 | 5,500 | 95,315 | 342,241 | Aug 10, 2018, 06:47 PM |
| Shak Steven | Chief Scientific Officer | Aug 09, 2018 | Sale | $55.92 | 5,500 | 307,576 | 339,241 | Aug 10, 2018, 06:47 PM |
| Pla Frederic | Chief Bus & Prod Dev Officer | Aug 09, 2018 | Option Exercise | $27.00 | 1,500 | 40,500 | 41,038 | Aug 10, 2018, 06:45 PM |
| Pla Frederic | Chief Bus & Prod Dev Officer | Aug 09, 2018 | Sale | $55.93 | 5,500 | 307,625 | 40,238 | Aug 10, 2018, 06:45 PM |
| Cole G Bradley | COO | Aug 09, 2018 | Option Exercise | $17.18 | 8,529 | 146,528 | 53,901 | Aug 10, 2018, 06:41 PM |
| Cole G Bradley | COO | Aug 09, 2018 | Sale | $55.94 | 8,529 | 477,105 | 49,390 | Aug 10, 2018, 06:41 PM |
| Cole G Bradley | COO | Mar 08, 2017 | Option Exercise | $23.31 | 100 | 2,331 | 39,828 | Aug 10, 2018, 06:39 PM |
| Radford Jason W. | Chief Legal Officer | Aug 08, 2018 | Sale | $56.39 | 4,126 | 232,681 | 34,750 | Aug 10, 2018, 06:36 PM |
| Cohen Fred E | Director | Aug 07, 2018 | Option Exercise | $25.79 | 8,250 | 212,768 | 75,572 | Aug 09, 2018, 07:47 PM |
| Cohen Fred E | Director | Aug 07, 2018 | Sale | $56.22 | 8,250 | 463,800 | 68,722 | Aug 09, 2018, 07:47 PM |
| GRAHAM GINGER L | Director | Aug 06, 2018 | Option Exercise | $17.33 | 16,500 | 285,945 | 26,756 | Aug 08, 2018, 04:28 PM |
| Popovits Kimberly J | President and CEO | Jul 16, 2018 | Option Exercise | $17.18 | 10,000 | 171,800 | 246,157 | Jul 18, 2018, 04:40 PM |
| Popovits Kimberly J | President and CEO | Jul 16, 2018 | Sale | $53.27 | 10,000 | 532,685 | 243,158 | Jul 18, 2018, 04:40 PM |
| Shak Steven | Chief Scientific Officer | Jul 09, 2018 | Option Exercise | $17.33 | 5,500 | 95,315 | 341,416 | Jul 10, 2018, 05:18 PM |
| Shak Steven | Chief Scientific Officer | Jul 09, 2018 | Sale | $49.56 | 5,500 | 272,554 | 335,916 | Jul 10, 2018, 05:18 PM |
| Cohen Fred E | Director | Jul 01, 2018 | Option Exercise | $50.40 | 198 | 9,979 | 67,322 | Jul 03, 2018, 04:03 PM |
| GRAHAM GINGER L | Director | Jul 01, 2018 | Option Exercise | $50.40 | 198 | 9,979 | 10,256 | Jul 03, 2018, 04:02 PM |
| FUCHS HENRY J | Director | Jul 01, 2018 | Option Exercise | $50.40 | 198 | 9,979 | 6,035 | Jul 03, 2018, 04:01 PM |
| BAKER BROS. ADVISORS LP | Director | Jul 01, 2018 | Option Exercise | $50.40 | 2,376 | 119,750 | 11,370,316 | Jul 03, 2018, 12:00 AM |
| Popovits Kimberly J | President and CEO | Jun 14, 2018 | Option Exercise | $17.18 | 10,000 | 171,800 | 246,157 | Jun 18, 2018, 07:16 PM |
| Popovits Kimberly J | President and CEO | Jun 14, 2018 | Sale | $48.89 | 10,000 | 488,916 | 236,557 | Jun 18, 2018, 07:16 PM |
| Shak Steven | Chief Scientific Officer | Jun 11, 2018 | Option Exercise | $17.33 | 5,500 | 95,315 | 341,416 | Jun 13, 2018, 06:59 PM |
| Shak Steven | Chief Scientific Officer | Jun 11, 2018 | Sale | $50.22 | 5,500 | 276,200 | 336,425 | Jun 13, 2018, 06:59 PM |
| Vaughn James J | Chief Commercial Officer | Jun 04, 2018 | Option Exercise | $25.98 | 80,768 | 2,097,997 | 49,655 | Jun 06, 2018, 07:57 PM |
| Vaughn James J | Chief Commercial Officer | Jun 04, 2018 | Sale | $45.78 | 93,414 | 4,276,165 | 42,103 | Jun 06, 2018, 07:57 PM |
| Radford Jason W. | Chief Legal Officer | May 15, 2018 | Option Exercise | $38.00 | 1,153 | 43,814 | 37,667 | May 16, 2018, 08:23 PM |
| Popovits Kimberly J | President and CEO | May 14, 2018 | Option Exercise | $17.18 | 10,000 | 171,800 | 246,157 | May 16, 2018, 06:41 PM |
| Popovits Kimberly J | President and CEO | May 14, 2018 | Sale | $38.09 | 10,000 | 380,877 | 241,157 | May 16, 2018, 06:41 PM |
| Shak Steven | Chief Scientific Officer | May 09, 2018 | Option Exercise | $17.33 | 5,500 | 95,315 | 341,416 | May 11, 2018, 03:10 PM |
| Shak Steven | Chief Scientific Officer | May 09, 2018 | Sale | $36.64 | 5,500 | 201,543 | 338,491 | May 11, 2018, 03:10 PM |
| Vaughn James J | Chief Commercial Officer | May 02, 2018 | Sale | $32.50 | 1,497 | 48,653 | 29,655 | May 04, 2018, 08:59 PM |
| Popovits Kimberly J | President and CEO | Apr 16, 2018 | Option Exercise | $17.18 | 15,000 | 257,700 | 251,157 | Apr 18, 2018, 04:33 PM |
| Popovits Kimberly J | President and CEO | Apr 16, 2018 | Sale | $33.19 | 15,000 | 497,880 | 236,157 | Apr 18, 2018, 04:33 PM |
| FUCHS HENRY J | Director | Apr 01, 2018 | Option Exercise | $31.29 | 319 | 9,982 | 5,837 | Apr 03, 2018, 08:32 PM |
| Cohen Fred E | Director | Apr 01, 2018 | Option Exercise | $31.29 | 319 | 9,982 | 67,124 | Apr 03, 2018, 08:32 PM |
| GRAHAM GINGER L | Director | Apr 01, 2018 | Option Exercise | $31.29 | 319 | 9,982 | 10,058 | Apr 03, 2018, 08:31 PM |
| BAKER BROS. ADVISORS LP | Director | Apr 01, 2018 | Option Exercise | $31.29 | 3,828 | 119,778 | 11,369,920 | Apr 03, 2018, 06:01 PM |
| Popovits Kimberly J | President and CEO | Mar 14, 2018 | Option Exercise | $17.18 | 5,000 | 85,900 | 241,157 | Mar 16, 2018, 06:54 PM |
| Popovits Kimberly J | President and CEO | Mar 14, 2018 | Sale | $32.01 | 5,000 | 160,048 | 236,157 | Mar 16, 2018, 06:54 PM |
| Cole G Bradley | COO | Mar 13, 2018 | Option Exercise | $17.33 | 5,000 | 86,650 | 49,754 | Mar 15, 2018, 04:31 PM |
| Cole G Bradley | COO | Mar 13, 2018 | Sale | $32.80 | 5,000 | 164,014 | 45,054 | Mar 15, 2018, 04:31 PM |
| BAKER BROS. ADVISORS LP | Director | Mar 09, 2018 | Option Exercise | $18.50 | 49,500 | 915,750 | 11,369,282 | Mar 12, 2018, 06:04 PM |
| Leber Laura | Chief Communication Officer | Feb 20, 2018 | Sale | $32.92 | 3,374 | 111,080 | 16,731 | Feb 22, 2018, 04:24 PM |
| Febbo Phillip G. | Chief Medical Officer | Feb 20, 2018 | Sale | $32.84 | 4,942 | 162,290 | 21,687 | Feb 22, 2018, 04:19 PM |
| Cole G Bradley | COO | Feb 20, 2018 | Option Exercise | $17.33 | 5,000 | 86,650 | 49,754 | Feb 22, 2018, 04:19 PM |
| Cole G Bradley | COO | Feb 20, 2018 | Sale | $32.89 | 5,000 | 164,474 | 44,954 | Feb 22, 2018, 04:19 PM |
| Pla Frederic | Chief Bus & Prod Dev Officer | Feb 15, 2018 | Option Exercise | $32.66 | 3,600 | 117,576 | 38,712 | Feb 20, 2018, 06:40 PM |
| Radford Jason W. | Chief Legal Officer | Feb 15, 2018 | Option Exercise | $32.66 | 2,065 | 67,443 | 38,820 | Feb 20, 2018, 05:59 PM |
| McEachron Kim | Chief People Officer | Feb 15, 2018 | Option Exercise | $32.66 | 2,221 | 72,538 | 33,727 | Feb 20, 2018, 05:59 PM |
| Leber Laura | Chief Communication Officer | Feb 15, 2018 | Option Exercise | $32.66 | 1,999 | 65,287 | 19,905 | Feb 20, 2018, 05:58 PM |
| Febbo Phillip G. | Chief Medical Officer | Feb 15, 2018 | Option Exercise | $32.66 | 2,801 | 91,481 | 26,329 | Feb 20, 2018, 05:57 PM |
| Vaughn James J | Chief Commercial Officer | Feb 15, 2018 | Option Exercise | $32.66 | 3,115 | 101,736 | 31,152 | Feb 20, 2018, 05:56 PM |
| Pla Frederic | Chief Bus & Prod Dev Officer | Feb 15, 2018 | Option Exercise | $32.66 | 3,600 | 117,576 | 38,712 | Feb 20, 2018, 05:55 PM |
| Shak Steven | Chief Scientific Officer | Feb 15, 2018 | Option Exercise | $32.66 | 2,825 | 92,264 | 335,916 | Feb 20, 2018, 05:55 PM |
| Cole G Bradley | COO | Feb 15, 2018 | Option Exercise | $32.66 | 3,182 | 103,924 | 44,754 | Feb 20, 2018, 05:54 PM |
| Popovits Kimberly J | President and CEO | Feb 15, 2018 | Option Exercise | $32.66 | 6,232 | 203,537 | 59,617 | Feb 20, 2018, 05:53 PM |
| Popovits Kimberly J | President and CEO | Feb 14, 2018 | Option Exercise | $17.18 | 10,000 | 171,800 | 75,849 | Feb 15, 2018, 04:02 PM |
| Popovits Kimberly J | President and CEO | Feb 14, 2018 | Sale | $32.93 | 10,000 | 329,336 | 65,849 | Feb 15, 2018, 04:02 PM |
| Popovits Kimberly J | President and CEO | Jan 16, 2018 | Option Exercise | $17.18 | 10,000 | 171,800 | 51,719 | Jan 18, 2018, 09:30 PM |
| Popovits Kimberly J | President and CEO | Jan 16, 2018 | Sale | $34.99 | 10,000 | 349,885 | 41,919 | Jan 18, 2018, 09:30 PM |
| Cole G Bradley | COO | Jan 09, 2018 | Option Exercise | $17.33 | 5,000 | 86,650 | 45,346 | Jan 10, 2018, 09:17 PM |
| Cole G Bradley | COO | Jan 09, 2018 | Sale | $35.51 | 5,000 | 177,565 | 40,346 | Jan 10, 2018, 09:17 PM |
| Vaughn James J | Chief Commercial Officer | Jan 02, 2018 | Option Exercise | $17.33 | 2,169 | 37,589 | 30,481 | Jan 04, 2018, 07:54 PM |
| Vaughn James J | Chief Commercial Officer | Jan 02, 2018 | Sale | $34.09 | 3,004 | 102,406 | 28,312 | Jan 04, 2018, 07:54 PM |
| Cohen Fred E | Director | Jan 01, 2018 | Option Exercise | $34.20 | 292 | 9,986 | 66,805 | Jan 03, 2018, 06:22 PM |
| FUCHS HENRY J | Director | Jan 01, 2018 | Option Exercise | $34.20 | 292 | 9,986 | 5,518 | Jan 03, 2018, 06:22 PM |
| GRAHAM GINGER L | Director | Jan 01, 2018 | Option Exercise | $34.20 | 292 | 9,986 | 9,739 | Jan 03, 2018, 06:21 PM |
| BAKER BROS. ADVISORS LP | Director | Jan 01, 2018 | Option Exercise | $34.20 | 3,504 | 119,837 | 11,361,032 | Jan 03, 2018, 12:00 AM |
| Febbo Phillip G. | Chief Medical Officer | Dec 19, 2017 | Option Exercise | $27.00 | 5,000 | 135,000 | 23,134 | Dec 20, 2017, 04:35 PM |
| Febbo Phillip G. | Chief Medical Officer | Dec 19, 2017 | Sale | $36.99 | 5,334 | 197,298 | 18,134 | Dec 20, 2017, 04:35 PM |
| Leber Laura | Chief Communication Officer | Dec 15, 2017 | Option Exercise | $17.33 | 9,000 | 155,970 | 24,754 | Dec 18, 2017, 07:52 PM |
| Leber Laura | Chief Communication Officer | Dec 14, 2017 | Option Exercise | $21.52 | 12,000 | 258,240 | 27,754 | Dec 18, 2017, 07:52 PM |
| Leber Laura | Chief Communication Officer | Dec 14, 2017 | Sale | $32.00 | 12,000 | 384,000 | 15,754 | Dec 18, 2017, 07:52 PM |
| Leber Laura | Chief Communication Officer | Dec 15, 2017 | Sale | $35.00 | 9,000 | 315,000 | 15,754 | Dec 18, 2017, 07:52 PM |
| Popovits Kimberly J | President and CEO | Dec 14, 2017 | Option Exercise | $17.28 | 20,000 | 345,535 | 61,919 | Dec 18, 2017, 07:51 PM |
| Popovits Kimberly J | President and CEO | Dec 14, 2017 | Sale | $31.50 | 20,000 | 630,000 | 51,919 | Dec 18, 2017, 07:51 PM |
| Cole G Bradley | COO | Dec 12, 2017 | Option Exercise | $17.33 | 5,000 | 86,650 | 45,346 | Dec 14, 2017, 07:03 PM |
| Cole G Bradley | COO | Dec 12, 2017 | Sale | $29.94 | 5,000 | 149,708 | 40,346 | Dec 14, 2017, 07:03 PM |
| Cole G Bradley | COO | Dec 12, 2017 | Option Exercise | $17.33 | 5,000 | 86,650 | 44,935 | Dec 13, 2017, 04:14 PM |
| Cole G Bradley | COO | Dec 12, 2017 | Sale | $29.94 | 5,000 | 149,708 | 39,935 | Dec 13, 2017, 04:14 PM |
| Cole G Bradley | COO | Nov 07, 2017 | Option Exercise | $17.33 | 5,000 | 86,650 | 44,935 | Nov 09, 2017, 04:59 PM |
| Cole G Bradley | COO | Nov 07, 2017 | Sale | $31.47 | 5,000 | 157,330 | 39,935 | Nov 09, 2017, 04:59 PM |
| Vaughn James J | Chief Commercial Officer | Nov 02, 2017 | Option Exercise | $17.33 | 924 | 16,013 | 28,999 | Nov 08, 2017, 05:29 PM |
| Vaughn James J | Chief Commercial Officer | Nov 01, 2017 | Option Exercise | $17.33 | 3,907 | 67,708 | 33,692 | Nov 08, 2017, 05:29 PM |
| Vaughn James J | Chief Commercial Officer | Nov 01, 2017 | Sale | $32.58 | 5,617 | 183,001 | 31,282 | Nov 08, 2017, 05:29 PM |
| Vaughn James J | Chief Commercial Officer | Nov 02, 2017 | Sale | $32.51 | 1,379 | 44,827 | 28,175 | Nov 08, 2017, 05:29 PM |
| Cole G Bradley | COO | Oct 10, 2017 | Option Exercise | $17.33 | 5,000 | 86,650 | 44,935 | Oct 11, 2017, 05:55 PM |
| Cole G Bradley | COO | Oct 10, 2017 | Sale | $31.93 | 5,000 | 159,636 | 39,935 | Oct 11, 2017, 05:55 PM |
| FUCHS HENRY J | Director | Oct 01, 2017 | Option Exercise | $32.09 | 311 | 9,980 | 5,226 | Oct 03, 2017, 06:17 PM |
| Cohen Fred E | Director | Oct 01, 2017 | Option Exercise | $32.09 | 311 | 9,980 | 66,513 | Oct 03, 2017, 06:16 PM |
| GRAHAM GINGER L | Director | Oct 01, 2017 | Option Exercise | $32.09 | 311 | 9,980 | 9,447 | Oct 03, 2017, 06:15 PM |
| BAKER BROS. ADVISORS LP | Director | Oct 01, 2017 | Option Exercise | $32.09 | 3,732 | 119,760 | 11,360,448 | Oct 03, 2017, 05:39 PM |
| Popovits Kimberly J | President and CEO | Sep 14, 2017 | Option Exercise | $17.33 | 5,000 | 86,650 | 46,132 | Sep 18, 2017, 04:02 PM |
| Popovits Kimberly J | President and CEO | Sep 14, 2017 | Sale | $31.00 | 5,000 | 154,989 | 41,132 | Sep 18, 2017, 04:02 PM |
| Cole G Bradley | COO | Sep 12, 2017 | Option Exercise | $17.33 | 5,000 | 86,650 | 44,935 | Sep 14, 2017, 05:12 PM |
| Cole G Bradley | COO | Sep 12, 2017 | Sale | $31.86 | 5,000 | 159,288 | 39,935 | Sep 14, 2017, 05:12 PM |
| Popovits Kimberly J | President and CEO | Aug 14, 2017 | Option Exercise | $17.33 | 5,000 | 86,650 | 84,057 | Aug 16, 2017, 08:02 PM |
| Popovits Kimberly J | President and CEO | Aug 14, 2017 | Sale | $30.22 | 5,000 | 151,111 | 79,057 | Aug 16, 2017, 08:02 PM |
| Vaughn James J | Chief Commercial Officer | Aug 08, 2017 | Option Exercise | $23.31 | 6,500 | 151,515 | 37,785 | Aug 09, 2017, 07:52 PM |
| Vaughn James J | Chief Commercial Officer | Aug 08, 2017 | Sale | $30.59 | 8,000 | 244,724 | 29,785 | Aug 09, 2017, 07:52 PM |
| Cole G Bradley | COO | Aug 08, 2017 | Option Exercise | $17.33 | 5,000 | 86,650 | 44,935 | Aug 09, 2017, 07:51 PM |
| Cole G Bradley | COO | Aug 08, 2017 | Sale | $30.57 | 5,000 | 152,845 | 39,935 | Aug 09, 2017, 07:51 PM |
| Febbo Phillip G. | Chief Medical Officer | Jul 19, 2017 | Sale | $33.57 | 3,174 | 106,538 | 18,130 | Jul 21, 2017, 04:20 PM |
| Cole G Bradley | COO | Jul 11, 2017 | Option Exercise | $17.33 | 5,000 | 86,650 | 44,935 | Jul 13, 2017, 05:23 PM |
| Cole G Bradley | COO | Jul 11, 2017 | Sale | $32.53 | 5,000 | 162,667 | 40,008 | Jul 13, 2017, 05:23 PM |
| Popovits Kimberly J | President and CEO | Jul 05, 2017 | Option Exercise | $17.33 | 1,468 | 25,440 | 80,525 | Jul 06, 2017, 07:28 PM |
| Popovits Kimberly J | President and CEO | Jul 03, 2017 | Option Exercise | $17.33 | 3,532 | 61,210 | 82,589 | Jul 06, 2017, 07:28 PM |
| Popovits Kimberly J | President and CEO | Jul 05, 2017 | Sale | $32.67 | 1,468 | 47,952 | 79,057 | Jul 06, 2017, 07:28 PM |
| Popovits Kimberly J | President and CEO | Jul 03, 2017 | Sale | $32.56 | 3,532 | 114,988 | 79,057 | Jul 06, 2017, 07:28 PM |
| FUCHS HENRY J | Director | Jul 01, 2017 | Option Exercise | $32.55 | 307 | 9,993 | 4,915 | Jul 05, 2017, 07:04 PM |
| Cohen Fred E | Director | Jul 01, 2017 | Option Exercise | $32.55 | 307 | 9,993 | 66,202 | Jul 05, 2017, 07:03 PM |
| GRAHAM GINGER L | Director | Jul 01, 2017 | Option Exercise | $32.55 | 307 | 9,993 | 9,136 | Jul 05, 2017, 07:03 PM |
| BAKER BROS. ADVISORS LP | Director | Jul 01, 2017 | Option Exercise | $32.55 | 3,684 | 119,914 | 11,359,826 | Jul 05, 2017, 06:19 PM |
| Shak Steven | Chief Scientific Officer | Jun 23, 2017 | Option Exercise | $23.31 | 5,000 | 116,550 | 336,924 | Jun 27, 2017, 06:11 PM |
| Shak Steven | Chief Scientific Officer | Jun 23, 2017 | Sale | $33.27 | 5,000 | 166,371 | 331,924 | Jun 27, 2017, 06:11 PM |
| Cole G Bradley | COO | Jun 13, 2017 | Option Exercise | $17.33 | 5,000 | 86,650 | 44,935 | Jun 15, 2017, 04:40 PM |
| Cole G Bradley | COO | Jun 13, 2017 | Sale | $31.67 | 5,000 | 158,342 | 39,935 | Jun 15, 2017, 04:40 PM |
| Popovits Kimberly J | President and CEO | Jun 05, 2017 | Option Exercise | $17.33 | 5,000 | 86,650 | 84,057 | Jun 07, 2017, 07:07 PM |
| Popovits Kimberly J | President and CEO | Jun 05, 2017 | Sale | $32.32 | 5,000 | 161,582 | 79,057 | Jun 07, 2017, 07:07 PM |
| BAKER BROS. ADVISORS LP | Director | May 31, 2017 | Option Exercise | $18.13 | 49,500 | 897,435 | 11,359,212 | Jun 01, 2017, 05:19 PM |
| Shak Steven | Chief Scientific Officer | May 23, 2017 | Option Exercise | $23.31 | 5,000 | 116,550 | 336,103 | May 25, 2017, 04:39 PM |
| Shak Steven | Chief Scientific Officer | May 23, 2017 | Sale | $29.40 | 5,000 | 146,981 | 331,103 | May 25, 2017, 04:39 PM |
| Cohen Fred E | Director | May 19, 2017 | Option Exercise | $14.37 | 8,250 | 118,552 | 74,145 | May 23, 2017, 08:16 PM |
| Cohen Fred E | Director | May 19, 2017 | Sale | $29.54 | 8,250 | 243,745 | 65,895 | May 23, 2017, 08:16 PM |
| Cohen Fred E | Director | May 18, 2017 | Option Exercise | $18.05 | 16,500 | 297,743 | 82,395 | May 22, 2017, 06:59 PM |
| Cohen Fred E | Director | May 18, 2017 | Sale | $29.88 | 16,500 | 493,040 | 65,895 | May 22, 2017, 06:59 PM |
| Cohen Fred E | Director | May 16, 2017 | Option Exercise | $18.13 | 8,250 | 149,572 | 74,145 | May 18, 2017, 07:52 PM |
| Cohen Fred E | Director | May 16, 2017 | Sale | $30.68 | 8,250 | 253,102 | 65,895 | May 18, 2017, 07:52 PM |
| Radford Jason W. | Chief Legal Officer | May 15, 2017 | Option Exercise | $30.81 | 1,253 | 38,605 | 24,902 | May 17, 2017, 07:42 PM |
| Popovits Kimberly J | President and CEO | May 03, 2017 | Option Exercise | $17.33 | 5,000 | 86,650 | 83,236 | May 04, 2017, 05:12 PM |
| Popovits Kimberly J | President and CEO | May 03, 2017 | Sale | $31.77 | 5,000 | 158,849 | 80,529 | May 04, 2017, 05:12 PM |
| Shak Steven | Chief Scientific Officer | Apr 24, 2017 | Option Exercise | $23.31 | 5,000 | 116,550 | 336,103 | Apr 26, 2017, 05:09 PM |
| Shak Steven | Chief Scientific Officer | Apr 24, 2017 | Sale | $31.46 | 5,000 | 157,323 | 331,103 | Apr 26, 2017, 05:09 PM |
| Popovits Kimberly J | President and CEO | Apr 03, 2017 | Option Exercise | $20.80 | 5,000 | 103,992 | 83,236 | Apr 05, 2017, 05:25 PM |
| Popovits Kimberly J | President and CEO | Apr 03, 2017 | Sale | $31.30 | 5,000 | 156,507 | 78,236 | Apr 05, 2017, 05:25 PM |
| BAKER BROS. ADVISORS LP | Director | Apr 01, 2017 | Option Exercise | $31.49 | 3,804 | 119,788 | 11,350,962 | Apr 04, 2017, 07:32 PM |
| FUCHS HENRY J | Director | Apr 01, 2017 | Option Exercise | $31.49 | 317 | 9,982 | 4,608 | Apr 04, 2017, 05:28 PM |
| Cohen Fred E | Director | Apr 01, 2017 | Option Exercise | $31.49 | 317 | 9,982 | 65,895 | Apr 04, 2017, 05:27 PM |
| GRAHAM GINGER L | Director | Apr 01, 2017 | Option Exercise | $31.49 | 317 | 9,982 | 8,829 | Apr 04, 2017, 05:26 PM |
| Shak Steven | Chief Scientific Officer | Mar 23, 2017 | Option Exercise | $23.31 | 5,000 | 116,550 | 336,103 | Mar 24, 2017, 07:05 PM |
| Shak Steven | Chief Scientific Officer | Mar 23, 2017 | Sale | $31.26 | 5,000 | 156,294 | 331,103 | Mar 24, 2017, 07:05 PM |
| Leber Laura | Chief Communication Officer | Mar 20, 2017 | Sale | $31.88 | 3,072 | 97,941 | 14,627 | Mar 22, 2017, 04:03 PM |
| Cole G Bradley | COO | Mar 08, 2017 | Option Exercise | $23.31 | 5,710 | 133,100 | 45,338 | Mar 10, 2017, 06:21 PM |
| Cole G Bradley | COO | Mar 08, 2017 | Sale | $31.55 | 5,710 | 180,134 | 39,728 | Mar 10, 2017, 06:21 PM |
| Popovits Kimberly J | President and CEO | Mar 06, 2017 | Option Exercise | $23.31 | 290 | 6,760 | 78,526 | Mar 07, 2017, 08:34 PM |
| Popovits Kimberly J | President and CEO | Mar 03, 2017 | Option Exercise | $23.31 | 4,710 | 109,790 | 82,946 | Mar 07, 2017, 08:34 PM |
| Popovits Kimberly J | President and CEO | Mar 03, 2017 | Sale | $31.09 | 4,710 | 146,440 | 78,236 | Mar 07, 2017, 08:34 PM |
| Popovits Kimberly J | President and CEO | Mar 06, 2017 | Sale | $31.08 | 290 | 9,014 | 78,236 | Mar 07, 2017, 08:34 PM |
| Shak Steven | Chief Scientific Officer | Feb 23, 2017 | Option Exercise | $23.31 | 5,000 | 116,550 | 336,103 | Feb 27, 2017, 09:56 PM |
| Shak Steven | Chief Scientific Officer | Feb 23, 2017 | Sale | $29.36 | 5,000 | 146,815 | 331,103 | Feb 27, 2017, 09:56 PM |
| Vaughn James J | Chief Commercial Officer | Feb 15, 2017 | Option Exercise | $31.12 | 3,417 | 106,337 | 30,502 | Feb 17, 2017, 06:51 PM |
| Shak Steven | Chief Scientific Officer | Feb 15, 2017 | Option Exercise | $31.12 | 2,884 | 89,750 | 331,103 | Feb 17, 2017, 06:50 PM |
| Radford Jason W. | Chief Legal Officer | Feb 15, 2017 | Option Exercise | $31.12 | 771 | 23,994 | 26,155 | Feb 17, 2017, 06:49 PM |
| Popovits Kimberly J | President and CEO | Feb 15, 2017 | Option Exercise | $31.12 | 4,982 | 155,040 | 78,236 | Feb 17, 2017, 06:48 PM |
| Pla Frederic | Chief Bus & Prod Dev Officer | Feb 15, 2017 | Option Exercise | $31.12 | 2,882 | 89,688 | 31,700 | Feb 17, 2017, 06:47 PM |
| McEachron Kim | Chief People Officer | Feb 15, 2017 | Option Exercise | $31.12 | 2,197 | 68,371 | 27,620 | Feb 17, 2017, 06:46 PM |
| Leber Laura | Chief Communication Officer | Feb 15, 2017 | Option Exercise | $31.12 | 2,078 | 64,667 | 17,699 | Feb 17, 2017, 06:45 PM |
| Febbo Phillip G. | Chief Medical Officer | Feb 15, 2017 | Option Exercise | $31.12 | 1,910 | 59,439 | 23,139 | Feb 17, 2017, 06:44 PM |
| Febbo Phillip G. | Chief Medical Officer | Feb 16, 2017 | Sale | $30.09 | 2,495 | 75,064 | 21,870 | Feb 17, 2017, 06:44 PM |
| Cole G Bradley | COO | Feb 15, 2017 | Option Exercise | $31.12 | 3,294 | 102,509 | 39,728 | Feb 17, 2017, 06:43 PM |
| Cole G Bradley | COO | Feb 15, 2017 | Option Exercise | $23.31 | 5,000 | 116,550 | 48,022 | Feb 17, 2017, 06:43 PM |
| Cole G Bradley | COO | Feb 15, 2017 | Sale | $29.00 | 5,000 | 145,000 | 43,022 | Feb 17, 2017, 06:43 PM |
| Shak Steven | Chief Scientific Officer | Jan 23, 2017 | Option Exercise | $23.31 | 5,000 | 116,550 | 332,207 | Jan 25, 2017, 08:01 PM |
| Shak Steven | Chief Scientific Officer | Jan 23, 2017 | Sale | $27.28 | 5,000 | 136,387 | 327,207 | Jan 25, 2017, 08:01 PM |
| Cole G Bradley | COO | Jan 10, 2017 | Option Exercise | $23.31 | 5,000 | 116,550 | 40,882 | Jan 12, 2017, 05:39 PM |
| Cole G Bradley | COO | Jan 10, 2017 | Sale | $29.22 | 5,000 | 146,087 | 35,882 | Jan 12, 2017, 05:39 PM |
| GRAHAM GINGER L | Director | Jan 01, 2017 | Option Exercise | $29.39 | 340 | 9,993 | 8,512 | Jan 04, 2017, 07:19 PM |
| FUCHS HENRY J | Director | Jan 01, 2017 | Option Exercise | $29.39 | 340 | 9,993 | 4,291 | Jan 04, 2017, 07:18 PM |
| Cohen Fred E | Director | Jan 01, 2017 | Option Exercise | $29.39 | 340 | 9,993 | 65,578 | Jan 04, 2017, 07:17 PM |
| BAKER FELIX | Director | Jan 01, 2017 | Option Exercise | $29.39 | 4,080 | 119,911 | 11,350,328 | Jan 04, 2017, 06:30 PM |
| Radford Jason W. | Chief Legal Officer | May 15, 2016 | Option Exercise | $27.28 | 1,420 | 38,738 | 14,554 | Dec 20, 2016, 05:15 PM |
| Febbo Phillip G. | Chief Medical Officer | Aug 15, 2016 | Option Exercise | $27.00 | 1,066 | 28,782 | 13,241 | Dec 20, 2016, 05:14 PM |
| Febbo Phillip G. | Chief Medical Officer | Aug 15, 2015 | Option Exercise | $24.85 | 1,065 | 26,465 | 14,307 | Dec 20, 2016, 05:14 PM |
| Cole G Bradley | COO | Dec 06, 2016 | Option Exercise | $23.31 | 5,000 | 116,550 | 40,882 | Dec 08, 2016, 08:12 PM |
| Cole G Bradley | COO | Dec 06, 2016 | Sale | $30.61 | 5,000 | 153,029 | 35,882 | Dec 08, 2016, 08:12 PM |
| Popovits Kimberly J | President and CEO | Dec 05, 2016 | Option Exercise | $23.31 | 5,000 | 116,550 | 64,620 | Dec 06, 2016, 07:17 PM |
| Popovits Kimberly J | President and CEO | Dec 05, 2016 | Sale | $30.02 | 5,000 | 150,100 | 59,620 | Dec 06, 2016, 07:17 PM |
| Leber Laura | Chief Communication Officer | Nov 21, 2016 | Option Exercise | $17.41 | 3,600 | 62,676 | 21,399 | Nov 23, 2016, 02:43 PM |
| Leber Laura | Chief Communication Officer | Nov 21, 2016 | Sale | $31.73 | 7,068 | 224,266 | 17,799 | Nov 23, 2016, 02:43 PM |
| Shak Steven | Chief Scientific Officer | Nov 10, 2016 | Option Exercise | $18.89 | 5,000 | 94,450 | 330,534 | Nov 15, 2016, 04:56 PM |
| Shak Steven | Chief Scientific Officer | Nov 10, 2016 | Sale | $31.71 | 5,000 | 158,569 | 327,207 | Nov 15, 2016, 04:56 PM |
| Cole G Bradley | COO | Nov 08, 2016 | Option Exercise | $23.31 | 5,000 | 116,550 | 40,426 | Nov 10, 2016, 07:37 PM |
| Cole G Bradley | COO | Nov 08, 2016 | Sale | $29.68 | 5,000 | 148,422 | 35,426 | Nov 10, 2016, 07:37 PM |
| Popovits Kimberly J | President and CEO | Nov 03, 2016 | Option Exercise | $18.89 | 5,313 | 100,363 | 64,933 | Nov 07, 2016, 06:53 PM |
| Popovits Kimberly J | President and CEO | Nov 03, 2016 | Sale | $28.88 | 5,313 | 153,423 | 59,620 | Nov 07, 2016, 06:53 PM |
| Shak Steven | Chief Scientific Officer | Oct 11, 2016 | Option Exercise | $18.89 | 5,000 | 94,450 | 332,207 | Oct 12, 2016, 07:24 PM |
| Shak Steven | Chief Scientific Officer | Oct 11, 2016 | Sale | $30.39 | 5,000 | 151,925 | 327,207 | Oct 12, 2016, 07:24 PM |
| Cole G Bradley | COO | Oct 10, 2016 | Option Exercise | $21.18 | 8,290 | 175,560 | 39,716 | Oct 12, 2016, 06:07 PM |
| Cole G Bradley | COO | Oct 10, 2016 | Sale | $30.59 | 8,290 | 253,572 | 35,426 | Oct 12, 2016, 06:07 PM |
| Vaughn James J | Chief Commercial Officer | Oct 06, 2016 | Sale | $29.68 | 3,000 | 89,042 | 26,079 | Oct 11, 2016, 08:07 PM |
| GRAHAM GINGER L | Director | Oct 01, 2016 | Option Exercise | $28.92 | 345 | 9,977 | 8,172 | Oct 04, 2016, 07:46 PM |
| FUCHS HENRY J | Director | Oct 01, 2016 | Option Exercise | $28.92 | 345 | 9,977 | 3,951 | Oct 04, 2016, 07:44 PM |
| Cohen Fred E | Director | Oct 01, 2016 | Option Exercise | $28.92 | 345 | 9,977 | 65,238 | Oct 04, 2016, 07:43 PM |
| BAKER FELIX | Director | Sep 30, 2016 | Option Exercise | $28.92 | 4,140 | 119,729 | 11,349,648 | Oct 04, 2016, 06:35 PM |
| Shak Steven | Chief Scientific Officer | Sep 13, 2016 | Option Exercise | $18.89 | 5,000 | 94,450 | 332,207 | Sep 15, 2016, 06:25 PM |
| Shak Steven | Chief Scientific Officer | Sep 13, 2016 | Sale | $26.83 | 5,000 | 134,156 | 327,207 | Sep 15, 2016, 06:25 PM |
| Cole G Bradley | COO | Sep 06, 2016 | Option Exercise | $18.89 | 4,000 | 75,560 | 39,426 | Sep 08, 2016, 06:36 PM |
| Cole G Bradley | COO | Sep 06, 2016 | Sale | $27.41 | 4,000 | 109,637 | 35,426 | Sep 08, 2016, 06:36 PM |
| Shak Steven | Chief Scientific Officer | Aug 23, 2016 | Option Exercise | $18.89 | 5,000 | 94,450 | 332,207 | Aug 25, 2016, 06:49 PM |
| Shak Steven | Chief Scientific Officer | Aug 23, 2016 | Sale | $27.24 | 5,000 | 136,215 | 327,207 | Aug 25, 2016, 06:49 PM |
| Cole G Bradley | COO | Aug 11, 2016 | Option Exercise | $18.89 | 5,000 | 94,450 | 40,426 | Aug 15, 2016, 06:03 PM |
| Cole G Bradley | COO | Aug 11, 2016 | Sale | $28.87 | 5,000 | 144,374 | 35,426 | Aug 15, 2016, 06:03 PM |
| BAKER FELIX | Director | Aug 15, 2016 | Buy | $27.02 | 100,000 | 2,701,590 | 11,348,958 | Aug 15, 2016, 06:02 PM |
| Vaughn James J | Chief Commercial Officer | Aug 08, 2016 | Sale | $28.74 | 3,000 | 86,221 | 29,079 | Aug 10, 2016, 07:09 PM |
| Shak Steven | Chief Scientific Officer | Jul 19, 2016 | Option Exercise | $18.89 | 5,000 | 94,450 | 332,207 | Jul 22, 2016, 04:13 PM |
| Shak Steven | Chief Scientific Officer | Jul 19, 2016 | Sale | $27.42 | 5,000 | 137,111 | 327,207 | Jul 22, 2016, 04:13 PM |
| Cole G Bradley | COO | Jul 06, 2016 | Option Exercise | $18.89 | 5,000 | 94,450 | 40,426 | Jul 08, 2016, 05:05 PM |
| Cole G Bradley | COO | Jul 06, 2016 | Sale | $26.64 | 5,000 | 133,223 | 35,426 | Jul 08, 2016, 05:05 PM |
| GRAHAM GINGER L | Director | Jul 01, 2016 | Option Exercise | $26.74 | 373 | 9,974 | 7,827 | Jul 06, 2016, 06:44 PM |
| FUCHS HENRY J | Director | Jul 01, 2016 | Option Exercise | $26.74 | 373 | 9,974 | 3,606 | Jul 06, 2016, 06:43 PM |
| Cohen Fred E | Director | Jul 01, 2016 | Option Exercise | $26.74 | 373 | 9,974 | 64,893 | Jul 06, 2016, 06:42 PM |
| BAKER FELIX | Director | Jul 01, 2016 | Option Exercise | $26.74 | 4,476 | 119,688 | 11,259,062 | Jul 06, 2016, 06:22 PM |
| Shak Steven | Chief Scientific Officer | Jun 21, 2016 | Option Exercise | $18.89 | 5,000 | 94,450 | 332,207 | Jun 23, 2016, 04:14 PM |
| Shak Steven | Chief Scientific Officer | Jun 21, 2016 | Sale | $25.77 | 5,000 | 128,859 | 327,307 | Jun 23, 2016, 04:14 PM |
| Cole G Bradley | COO | Jun 09, 2016 | Option Exercise | $18.89 | 5,000 | 94,450 | 40,426 | Jun 13, 2016, 04:13 PM |
| Cole G Bradley | COO | Jun 09, 2016 | Sale | $26.62 | 5,000 | 133,118 | 35,626 | Jun 13, 2016, 04:13 PM |
| Vaughn James J | Chief Commercial Officer | Jun 06, 2016 | Option Exercise | $18.89 | 1,997 | 37,723 | 34,076 | Jun 08, 2016, 04:49 PM |
| Vaughn James J | Chief Commercial Officer | Jun 06, 2016 | Sale | $28.00 | 1,997 | 55,916 | 32,079 | Jun 08, 2016, 04:49 PM |
| BAKER FELIX | Director | May 17, 2016 | Option Exercise | $10.73 | 49,500 | 531,135 | 11,258,316 | May 19, 2016, 06:23 PM |
| Cole G Bradley | COO | May 16, 2016 | Option Exercise | $18.89 | 5,000 | 94,450 | 39,970 | May 18, 2016, 07:34 PM |
| Cole G Bradley | COO | May 16, 2016 | Sale | $27.60 | 5,000 | 137,994 | 34,970 | May 18, 2016, 07:34 PM |
| Febbo Phillip G. | Chief Medical Officer | May 10, 2016 | Sale | $27.20 | 6,324 | 172,034 | 15,113 | May 12, 2016, 04:57 PM |
| Vaughn James J | Chief Commercial Officer | May 09, 2016 | Option Exercise | $18.89 | 2,000 | 37,780 | 33,255 | May 11, 2016, 04:42 PM |
| Vaughn James J | Chief Commercial Officer | May 09, 2016 | Sale | $28.00 | 2,000 | 56,000 | 31,255 | May 11, 2016, 04:42 PM |
| Shak Steven | Chief Scientific Officer | May 04, 2016 | Option Exercise | $18.89 | 10,000 | 188,900 | 336,383 | May 06, 2016, 06:13 PM |
| Shak Steven | Chief Scientific Officer | May 04, 2016 | Sale | $25.43 | 10,000 | 254,296 | 326,383 | May 06, 2016, 06:13 PM |
| BAKER FELIX | Director | Apr 01, 2016 | Option Exercise | $25.48 | 4,704 | 119,858 | 11,250,066 | Apr 05, 2016, 05:58 PM |
| GRAHAM GINGER L | Director | Apr 01, 2016 | Option Exercise | $25.48 | 392 | 9,988 | 7,454 | Apr 04, 2016, 09:00 PM |
| FUCHS HENRY J | Director | Apr 01, 2016 | Option Exercise | $25.48 | 392 | 9,988 | 3,233 | Apr 04, 2016, 08:59 PM |
| Cohen Fred E | Director | Apr 01, 2016 | Option Exercise | $25.48 | 392 | 9,988 | 64,520 | Apr 04, 2016, 08:58 PM |
| Vaughn James J | Chief Commercial Officer | Feb 15, 2016 | Option Exercise | $26.53 | 3,371 | 89,433 | 20,705 | Feb 17, 2016, 08:51 PM |
| Shak Steven | EVP of R&D | Feb 15, 2016 | Option Exercise | $26.53 | 2,795 | 74,151 | 318,073 | Feb 17, 2016, 08:50 PM |
| Pla Frederic | Chief Bus & Prod Dev Officer | Feb 15, 2016 | Option Exercise | $26.53 | 1,580 | 41,917 | 15,068 | Feb 17, 2016, 08:46 PM |
| McEachron Kim | Chief People Officer | Feb 15, 2016 | Option Exercise | $26.53 | 1,961 | 52,025 | 15,473 | Feb 17, 2016, 08:45 PM |
| Leber Laura | Chief Communication Officer | Feb 15, 2016 | Option Exercise | $26.53 | 2,093 | 55,527 | 10,866 | Feb 17, 2016, 08:44 PM |
| Febbo Phillip G. | Chief Medical Officer | Feb 15, 2016 | Option Exercise | $26.53 | 1,255 | 33,295 | 14,047 | Feb 17, 2016, 08:43 PM |
| Popovits Kimberly J | President and CEO | Feb 15, 2016 | Option Exercise | $26.53 | 3,195 | 84,763 | 32,496 | Feb 17, 2016, 08:20 PM |
| Cole G Bradley | COO | Feb 15, 2016 | Option Exercise | $26.53 | 3,008 | 79,802 | 24,420 | Feb 17, 2016, 08:07 PM |
| Vaughn James J | Chief Commercial Officer | Feb 09, 2016 | Option Exercise | $18.89 | 3 | 57 | 24,079 | Feb 11, 2016, 04:24 PM |
| Vaughn James J | Chief Commercial Officer | Feb 09, 2016 | Sale | $28.00 | 3 | 84 | 24,076 | Feb 11, 2016, 04:24 PM |
| LIVINGSTON RANDALL S | Director | Jan 13, 2016 | Option Exercise | $10.73 | 1,250 | 13,412 | 7,399 | Jan 15, 2016, 05:17 PM |
| LIVINGSTON RANDALL S | Director | Jan 13, 2016 | Sale | $32.14 | 1,250 | 40,175 | 6,149 | Jan 15, 2016, 05:17 PM |
| Popovits Kimberly J | President and CEO | Jan 12, 2016 | Option Exercise | $18.89 | 5,000 | 94,450 | 40,691 | Jan 14, 2016, 04:58 PM |
| Popovits Kimberly J | President and CEO | Jan 12, 2016 | Sale | $30.34 | 5,000 | 151,679 | 35,691 | Jan 14, 2016, 04:58 PM |
| Cole G Bradley | COO | Jan 12, 2016 | Option Exercise | $18.89 | 4,000 | 75,560 | 31,428 | Jan 14, 2016, 04:56 PM |
| Cole G Bradley | COO | Jan 12, 2016 | Sale | $31.69 | 4,000 | 126,771 | 30,886 | Jan 14, 2016, 04:56 PM |
| Vaughn James J | Chief Commercial Officer | Jan 07, 2016 | Option Exercise | $18.89 | 2,000 | 37,780 | 26,076 | Jan 08, 2016, 04:13 PM |
| Vaughn James J | Chief Commercial Officer | Jan 07, 2016 | Sale | $33.63 | 2,000 | 67,265 | 24,076 | Jan 08, 2016, 04:13 PM |
| BAKER FELIX | Director | Jan 01, 2016 | Option Exercise | $35.20 | 3,408 | 119,962 | 11,249,282 | Jan 05, 2016, 06:47 PM |
| FUCHS HENRY J | Director | Jan 01, 2016 | Option Exercise | $35.20 | 284 | 9,997 | 2,841 | Jan 05, 2016, 04:20 PM |
| GRAHAM GINGER L | Director | Jan 01, 2016 | Option Exercise | $35.20 | 284 | 9,997 | 7,062 | Jan 05, 2016, 04:18 PM |
| Cohen Fred E | Director | Jan 01, 2016 | Option Exercise | $35.20 | 284 | 9,997 | 64,128 | Jan 05, 2016, 04:17 PM |
| Popovits Kimberly J | President and CEO | Dec 15, 2015 | Option Exercise | $18.89 | 5,000 | 94,450 | 40,691 | Dec 17, 2015, 04:47 PM |
| Popovits Kimberly J | President and CEO | Dec 15, 2015 | Sale | $30.00 | 5,000 | 150,000 | 35,691 | Dec 17, 2015, 04:47 PM |
| Cole G Bradley | COO | Dec 08, 2015 | Option Exercise | $18.89 | 4,000 | 75,560 | 34,428 | Dec 10, 2015, 04:47 PM |
| Cole G Bradley | COO | Dec 08, 2015 | Sale | $29.26 | 4,000 | 117,030 | 30,428 | Dec 10, 2015, 04:47 PM |
| Leber Laura | Chief Communication Officer | Dec 07, 2015 | Option Exercise | $10.15 | 4,200 | 42,630 | 17,159 | Dec 09, 2015, 03:03 PM |
| Leber Laura | Chief Communication Officer | Dec 07, 2015 | Sale | $29.33 | 4,200 | 123,202 | 12,959 | Dec 09, 2015, 03:03 PM |
| Vaughn James J | Chief Commercial Officer | Dec 07, 2015 | Option Exercise | $18.89 | 2,000 | 37,780 | 26,076 | Dec 09, 2015, 03:02 PM |
| Vaughn James J | Chief Commercial Officer | Dec 07, 2015 | Sale | $29.33 | 2,000 | 58,668 | 24,076 | Dec 09, 2015, 03:02 PM |
| Cole G Bradley | COO | Nov 10, 2015 | Option Exercise | $18.89 | 4,000 | 75,560 | 34,326 | Nov 12, 2015, 04:08 PM |
| Cole G Bradley | COO | Nov 10, 2015 | Sale | $26.03 | 4,000 | 104,128 | 30,326 | Nov 12, 2015, 04:08 PM |
| BAKER FELIX | Director | Oct 01, 2015 | Option Exercise | $21.34 | 5,616 | 119,845 | 11,248,714 | Oct 05, 2015, 07:17 PM |
| GRAHAM GINGER L | Director | Oct 01, 2015 | Option Exercise | $21.34 | 468 | 9,987 | 6,778 | Oct 05, 2015, 05:04 PM |
| FUCHS HENRY J | Director | Oct 01, 2015 | Option Exercise | $21.34 | 468 | 9,987 | 2,557 | Oct 05, 2015, 05:02 PM |
| Cohen Fred E | Director | Oct 01, 2015 | Option Exercise | $21.34 | 468 | 9,987 | 63,844 | Oct 05, 2015, 05:01 PM |
| Cole G Bradley | COO | Sep 08, 2015 | Option Exercise | $9.39 | 6,000 | 56,340 | 36,326 | Sep 10, 2015, 04:38 PM |
| Cole G Bradley | COO | Sep 09, 2015 | Option Exercise | $9.39 | 3,664 | 34,405 | 33,990 | Sep 10, 2015, 04:38 PM |
| Cole G Bradley | COO | Sep 09, 2015 | Sale | $25.40 | 3,664 | 93,056 | 30,326 | Sep 10, 2015, 04:38 PM |
| Cole G Bradley | COO | Sep 08, 2015 | Sale | $25.32 | 6,000 | 151,929 | 30,326 | Sep 10, 2015, 04:38 PM |
| Cole G Bradley | COO | Jul 07, 2015 | Option Exercise | $9.39 | 4,000 | 37,560 | 34,326 | Jul 09, 2015, 07:25 PM |
| Cole G Bradley | COO | Jul 07, 2015 | Sale | $27.53 | 4,000 | 110,112 | 30,326 | Jul 09, 2015, 07:25 PM |
| BAKER FELIX | Director | Jul 01, 2015 | Option Exercise | $27.34 | 4,380 | 119,749 | 11,247,778 | Jul 06, 2015, 05:42 PM |
| GRAHAM GINGER L | Director | Jul 01, 2015 | Option Exercise | $27.34 | 365 | 9,979 | 6,310 | Jul 06, 2015, 05:06 PM |
| FUCHS HENRY J | Director | Jul 01, 2015 | Option Exercise | $27.34 | 365 | 9,979 | 2,089 | Jul 06, 2015, 05:04 PM |
| Cohen Fred E | Director | Jul 01, 2015 | Option Exercise | $27.34 | 365 | 9,979 | 63,376 | Jul 06, 2015, 05:03 PM |
| Cole G Bradley | COO | Jun 09, 2015 | Option Exercise | $9.39 | 4,000 | 37,560 | 34,326 | Jun 11, 2015, 05:34 PM |
| Cole G Bradley | COO | Jun 09, 2015 | Sale | $26.24 | 4,000 | 104,965 | 30,326 | Jun 11, 2015, 05:34 PM |
| Cole G Bradley | COO | May 12, 2015 | Option Exercise | $9.39 | 4,000 | 37,560 | 33,658 | May 14, 2015, 04:51 PM |
| Cole G Bradley | COO | May 12, 2015 | Sale | $27.54 | 4,000 | 110,157 | 31,558 | May 14, 2015, 04:51 PM |
| Popovits Kimberly J | President and CEO | Apr 13, 2015 | Option Exercise | $18.89 | 3,000 | 56,670 | 37,939 | Apr 15, 2015, 04:57 PM |
| Popovits Kimberly J | President and CEO | Apr 13, 2015 | Sale | $31.28 | 3,000 | 93,840 | 34,939 | Apr 15, 2015, 04:57 PM |
| Cole G Bradley | COO | Apr 07, 2015 | Option Exercise | $9.39 | 4,000 | 37,560 | 33,658 | Apr 09, 2015, 04:16 PM |
| Cole G Bradley | COO | Apr 07, 2015 | Sale | $30.44 | 4,000 | 121,747 | 29,658 | Apr 09, 2015, 04:16 PM |
| GRAHAM GINGER L | Director | Apr 01, 2015 | Option Exercise | $30.43 | 328 | 9,981 | 5,945 | Apr 03, 2015, 04:23 PM |
| FUCHS HENRY J | Director | Apr 01, 2015 | Option Exercise | $30.43 | 328 | 9,981 | 1,724 | Apr 03, 2015, 04:22 PM |
| Cohen Fred E | Director | Apr 01, 2015 | Option Exercise | $30.43 | 328 | 9,981 | 63,011 | Apr 03, 2015, 04:21 PM |
| BAKER FELIX | Director | Apr 01, 2015 | Option Exercise | $30.43 | 3,936 | 119,772 | 11,247,048 | Apr 02, 2015, 06:37 PM |
| Popovits Kimberly J | President and CEO | Mar 12, 2015 | Option Exercise | $18.89 | 3,000 | 56,670 | 37,939 | Mar 17, 2015, 05:50 PM |
| Popovits Kimberly J | President and CEO | Mar 12, 2015 | Sale | $31.91 | 3,000 | 95,717 | 34,939 | Mar 17, 2015, 05:50 PM |
| Cole G Bradley | COO | Mar 10, 2015 | Option Exercise | $9.39 | 4,000 | 37,560 | 33,658 | Mar 12, 2015, 04:05 PM |
| Cole G Bradley | COO | Mar 10, 2015 | Sale | $31.84 | 4,000 | 127,376 | 30,058 | Mar 12, 2015, 04:05 PM |
| Cole G Bradley | COO | Feb 15, 2015 | Option Exercise | $31.12 | 2,827 | 87,976 | 29,658 | Feb 18, 2015, 09:48 PM |
| Popovits Kimberly J | President and CEO | Feb 12, 2015 | Option Exercise | $18.89 | 3,000 | 56,670 | 39,965 | Feb 17, 2015, 07:12 PM |
| Popovits Kimberly J | President and CEO | Feb 12, 2015 | Sale | $29.86 | 3,000 | 89,566 | 36,965 | Feb 17, 2015, 07:12 PM |
| Cole G Bradley | COO | Feb 10, 2015 | Option Exercise | $9.39 | 4,000 | 37,560 | 25,645 | Feb 12, 2015, 05:30 PM |
| Cole G Bradley | COO | Feb 10, 2015 | Sale | $31.37 | 4,000 | 125,468 | 21,645 | Feb 12, 2015, 05:30 PM |
| LIVINGSTON RANDALL S | Director | Feb 02, 2015 | Option Exercise | $10.73 | 1,000 | 10,730 | 7,149 | Feb 04, 2015, 04:58 PM |
| LIVINGSTON RANDALL S | Director | Feb 02, 2015 | Sale | $31.93 | 1,000 | 31,931 | 6,149 | Feb 04, 2015, 04:58 PM |
| Popovits Kimberly J | President and CEO | Jan 12, 2015 | Option Exercise | $18.89 | 3,000 | 56,670 | 39,965 | Jan 14, 2015, 04:34 PM |
| Popovits Kimberly J | President and CEO | Jan 12, 2015 | Sale | $33.46 | 3,000 | 100,386 | 36,965 | Jan 14, 2015, 04:34 PM |
| BAKER FELIX | Director | Jan 01, 2015 | Option Exercise | $31.97 | 3,744 | 119,696 | 11,246,392 | Jan 05, 2015, 05:45 PM |
| GRAHAM GINGER L | Director | Jan 01, 2015 | Option Exercise | $31.97 | 312 | 9,975 | 5,617 | Jan 05, 2015, 04:29 PM |
| Cohen Fred E | Director | Jan 01, 2015 | Option Exercise | $31.97 | 312 | 9,975 | 62,683 | Jan 05, 2015, 04:27 PM |
| FUCHS HENRY J | Director | Jan 01, 2015 | Option Exercise | $31.97 | 312 | 9,975 | 1,396 | Jan 05, 2015, 04:26 PM |
| Popovits Kimberly J | President and CEO | Dec 11, 2014 | Option Exercise | $18.89 | 3,000 | 56,670 | 39,365 | Dec 15, 2014, 04:13 PM |
| Popovits Kimberly J | President and CEO | Dec 11, 2014 | Sale | $32.99 | 3,000 | 98,967 | 36,965 | Dec 15, 2014, 04:13 PM |
| Cole G Bradley | COO | Dec 08, 2014 | Option Exercise | $9.39 | 4,336 | 40,715 | 25,981 | Dec 09, 2014, 04:25 PM |
| Cole G Bradley | COO | Dec 08, 2014 | Sale | $32.52 | 4,336 | 141,004 | 21,645 | Dec 09, 2014, 04:25 PM |
| Popovits Kimberly J | President and CEO | Nov 12, 2014 | Option Exercise | $18.89 | 4,300 | 81,227 | 39,165 | Nov 14, 2014, 07:07 PM |
| Popovits Kimberly J | President and CEO | Nov 12, 2014 | Sale | $34.82 | 4,300 | 149,709 | 36,965 | Nov 14, 2014, 07:07 PM |
| Cole G Bradley | COO | Nov 10, 2014 | Option Exercise | $9.39 | 4,000 | 37,560 | 26,891 | Nov 12, 2014, 04:32 PM |
| Cole G Bradley | COO | Nov 10, 2014 | Sale | $35.35 | 4,000 | 141,388 | 22,891 | Nov 12, 2014, 04:32 PM |
| LIVINGSTON RANDALL S | Director | Nov 03, 2014 | Option Exercise | $10.73 | 3,000 | 32,190 | 9,149 | Nov 05, 2014, 05:01 PM |
| LIVINGSTON RANDALL S | Director | Nov 03, 2014 | Sale | $36.24 | 3,000 | 108,718 | 6,149 | Nov 05, 2014, 05:01 PM |
| Popovits Kimberly J | President and CEO | Oct 13, 2014 | Option Exercise | $18.89 | 3,000 | 56,670 | 39,965 | Oct 15, 2014, 04:22 PM |
| Popovits Kimberly J | President and CEO | Oct 13, 2014 | Sale | $30.78 | 3,000 | 92,326 | 36,965 | Oct 15, 2014, 04:22 PM |
| Cole G Bradley | COO | Oct 08, 2014 | Option Exercise | $9.39 | 4,000 | 37,560 | 26,891 | Oct 10, 2014, 04:19 PM |
| Cole G Bradley | COO | Oct 08, 2014 | Sale | $28.77 | 4,000 | 115,098 | 22,891 | Oct 10, 2014, 04:19 PM |
| BAKER FELIX | Director | Oct 01, 2014 | Option Exercise | $28.54 | 4,200 | 119,868 | 11,245,768 | Oct 03, 2014, 05:56 PM |
| GRAHAM GINGER L | Director | Oct 01, 2014 | Option Exercise | $28.54 | 350 | 9,989 | 5,305 | Oct 03, 2014, 04:30 PM |
| FUCHS HENRY J | Director | Oct 01, 2014 | Option Exercise | $28.54 | 350 | 9,989 | 1,084 | Oct 03, 2014, 04:28 PM |
| COLELLA SAMUEL D | Director | Oct 01, 2014 | Option Exercise | $28.54 | 350 | 9,989 | 5,305 | Oct 03, 2014, 04:27 PM |
| Cohen Fred E | Director | Oct 01, 2014 | Option Exercise | $28.54 | 350 | 9,989 | 62,371 | Oct 03, 2014, 04:26 PM |
| Popovits Kimberly J | President and CEO | Sep 11, 2014 | Option Exercise | $16.95 | 3,000 | 50,846 | 39,965 | Sep 15, 2014, 04:16 PM |
| Popovits Kimberly J | President and CEO | Sep 11, 2014 | Sale | $29.82 | 3,000 | 89,446 | 36,965 | Sep 15, 2014, 04:16 PM |
| Cole G Bradley | COO | Sep 08, 2014 | Option Exercise | $8.42 | 4,700 | 39,576 | 27,591 | Sep 10, 2014, 06:04 PM |
| Cole G Bradley | COO | Sep 08, 2014 | Sale | $30.09 | 4,700 | 141,429 | 22,891 | Sep 10, 2014, 06:04 PM |
| Shak Steven | EVP of R&D | Aug 14, 2014 | Option Exercise | $2.88 | 6,348 | 18,282 | 318,646 | Aug 15, 2014, 05:21 PM |
| Shak Steven | EVP of R&D | Aug 13, 2014 | Option Exercise | $2.88 | 7,000 | 20,160 | 319,298 | Aug 15, 2014, 05:21 PM |
| Shak Steven | EVP of R&D | Aug 13, 2014 | Sale | $27.25 | 7,000 | 190,726 | 312,298 | Aug 15, 2014, 05:21 PM |
| Shak Steven | EVP of R&D | Aug 14, 2014 | Sale | $27.49 | 6,348 | 174,498 | 312,298 | Aug 15, 2014, 05:21 PM |
| Popovits Kimberly J | President and CEO | Aug 12, 2014 | Option Exercise | $9.39 | 3,000 | 28,170 | 39,965 | Aug 14, 2014, 04:54 PM |
| Popovits Kimberly J | President and CEO | Aug 12, 2014 | Sale | $26.07 | 3,000 | 78,201 | 36,965 | Aug 14, 2014, 04:54 PM |
| Popovits Kimberly J | President and CEO | Jul 14, 2014 | Option Exercise | $9.39 | 3,000 | 28,170 | 39,965 | Jul 16, 2014, 04:17 PM |
| Popovits Kimberly J | President and CEO | Jul 14, 2014 | Sale | $26.59 | 3,000 | 79,777 | 36,965 | Jul 16, 2014, 04:17 PM |
| Cole G Bradley | COO | Jul 08, 2014 | Option Exercise | $2.88 | 2,300 | 6,624 | 25,191 | Jul 10, 2014, 04:19 PM |
| Cole G Bradley | COO | Jul 08, 2014 | Sale | $27.05 | 2,300 | 62,209 | 22,891 | Jul 10, 2014, 04:19 PM |
| Shak Steven | EVP of R&D | Jul 01, 2014 | Option Exercise | $2.88 | 7,000 | 20,160 | 319,298 | Jul 03, 2014, 06:04 PM |
| Shak Steven | EVP of R&D | Jul 01, 2014 | Sale | $27.00 | 7,000 | 188,970 | 312,298 | Jul 03, 2014, 06:04 PM |
| GRAHAM GINGER L | Director | Jul 01, 2014 | Option Exercise | $27.86 | 358 | 9,974 | 4,955 | Jul 03, 2014, 04:35 PM |
| FUCHS HENRY J | Director | Jul 01, 2014 | Option Exercise | $27.86 | 358 | 9,974 | 734 | Jul 03, 2014, 04:33 PM |
| COLELLA SAMUEL D | Director | Jul 01, 2014 | Option Exercise | $27.86 | 358 | 9,974 | 4,955 | Jul 03, 2014, 04:32 PM |
| Cohen Fred E | Director | Jul 01, 2014 | Option Exercise | $27.86 | 358 | 9,974 | 62,021 | Jul 03, 2014, 04:31 PM |
| BAKER FELIX | Director | Jul 01, 2014 | Option Exercise | $27.86 | 4,296 | 119,687 | 11,245,068 | Jul 03, 2014, 02:33 PM |
| Shak Steven | EVP of R&D | Jun 12, 2014 | Option Exercise | $2.88 | 7,000 | 20,160 | 319,298 | Jun 16, 2014, 06:08 PM |
| Shak Steven | EVP of R&D | Jun 12, 2014 | Sale | $26.73 | 7,000 | 187,107 | 316,398 | Jun 16, 2014, 06:08 PM |
| Popovits Kimberly J | President and CEO | Jun 12, 2014 | Option Exercise | $9.39 | 3,000 | 28,170 | 39,965 | Jun 16, 2014, 06:03 PM |
| Popovits Kimberly J | President and CEO | Jun 12, 2014 | Sale | $26.10 | 3,000 | 78,295 | 36,965 | Jun 16, 2014, 06:03 PM |
| Schorno Dean L | CFO | Jun 10, 2014 | Option Exercise | $18.03 | 4,000 | 72,140 | 28,524 | Jun 13, 2014, 08:07 PM |
| Schorno Dean L | CFO | Jun 10, 2014 | Sale | $27.62 | 4,000 | 110,487 | 24,524 | Jun 13, 2014, 08:07 PM |
| Cole G Bradley | COO | Jun 09, 2014 | Option Exercise | $2.88 | 2,337 | 6,731 | 25,228 | Jun 11, 2014, 05:48 PM |
| Cole G Bradley | COO | Jun 09, 2014 | Sale | $27.29 | 2,337 | 63,767 | 22,891 | Jun 11, 2014, 05:48 PM |
| Popovits Kimberly J | President and CEO | May 12, 2014 | Option Exercise | $9.39 | 3,000 | 28,170 | 39,255 | May 14, 2014, 04:04 PM |
| Popovits Kimberly J | President and CEO | May 12, 2014 | Sale | $26.54 | 3,000 | 79,617 | 36,646 | May 14, 2014, 04:04 PM |
| Schorno Dean L | CFO | May 09, 2014 | Option Exercise | $18.03 | 4,000 | 72,140 | 27,814 | May 13, 2014, 04:05 PM |
| Schorno Dean L | CFO | May 09, 2014 | Sale | $25.09 | 4,000 | 100,359 | 23,814 | May 13, 2014, 04:05 PM |
| Shak Steven | EVP of R&D | Apr 14, 2014 | Option Exercise | $2.88 | 7,000 | 20,160 | 318,547 | Apr 16, 2014, 04:19 PM |
| Shak Steven | EVP of R&D | Apr 14, 2014 | Sale | $26.25 | 7,000 | 183,734 | 311,588 | Apr 16, 2014, 04:19 PM |
| Cole G Bradley | COO | Apr 08, 2014 | Option Exercise | $2.88 | 3,000 | 8,640 | 25,226 | Apr 10, 2014, 04:20 PM |
| Cole G Bradley | COO | Apr 08, 2014 | Sale | $27.00 | 3,000 | 81,000 | 22,226 | Apr 10, 2014, 04:20 PM |
| BAKER FELIX | Director | Apr 01, 2014 | Option Exercise | $26.57 | 4,512 | 119,884 | 11,244,352 | Apr 03, 2014, 07:22 PM |
| FUCHS HENRY J | Director | Apr 01, 2014 | Option Exercise | $26.57 | 376 | 9,990 | 376 | Apr 03, 2014, 05:54 PM |
| GRAHAM GINGER L | Director | Apr 01, 2014 | Option Exercise | $26.57 | 376 | 9,990 | 4,597 | Apr 03, 2014, 04:00 PM |
| COLELLA SAMUEL D | Director | Apr 01, 2014 | Option Exercise | $26.57 | 376 | 9,990 | 4,597 | Apr 03, 2014, 03:59 PM |
| Cohen Fred E | Director | Apr 01, 2014 | Option Exercise | $26.57 | 376 | 9,990 | 61,663 | Apr 03, 2014, 03:57 PM |
| Shak Steven | EVP of R&D | Mar 14, 2014 | Option Exercise | $2.88 | 7,000 | 20,160 | 318,588 | Mar 18, 2014, 05:39 PM |
| Shak Steven | EVP of R&D | Mar 14, 2014 | Sale | $28.36 | 7,000 | 198,493 | 311,588 | Mar 18, 2014, 05:39 PM |
| Cole G Bradley | COO | Mar 10, 2014 | Option Exercise | $2.88 | 3,000 | 8,640 | 25,226 | Mar 12, 2014, 04:59 PM |
| Cole G Bradley | COO | Mar 10, 2014 | Sale | $27.76 | 3,000 | 83,290 | 22,226 | Mar 12, 2014, 04:59 PM |
| HIBBS KATHY L | SVP & General Counsel | Feb 15, 2014 | Option Exercise | $27.62 | 2,602 | 71,867 | 18,679 | Feb 19, 2014, 07:16 PM |
| HIBBS KATHY L | SVP & General Counsel | Feb 18, 2014 | Sale | $27.88 | 1,312 | 36,584 | 15,787 | Feb 19, 2014, 07:16 PM |
| Popovits Kimberly J | President and CEO | Feb 15, 2014 | Option Exercise | $27.62 | 3,611 | 99,736 | 38,636 | Feb 19, 2014, 07:15 PM |
| Cole G Bradley | COO | Feb 15, 2014 | Option Exercise | $27.62 | 2,563 | 70,790 | 23,817 | Feb 19, 2014, 07:14 PM |
| Schorno Dean L | CFO | Feb 15, 2014 | Option Exercise | $27.62 | 1,593 | 43,999 | 24,836 | Feb 19, 2014, 07:13 PM |
| Shak Steven | EVP of R&D | Feb 15, 2014 | Option Exercise | $27.62 | 2,055 | 56,759 | 312,971 | Feb 19, 2014, 07:11 PM |
| Shak Steven | EVP of R&D | Feb 14, 2014 | Option Exercise | $2.88 | 7,000 | 20,160 | 320,643 | Feb 19, 2014, 07:11 PM |
| Shak Steven | EVP of R&D | Feb 14, 2014 | Sale | $27.38 | 7,000 | 191,630 | 313,643 | Feb 19, 2014, 07:11 PM |
| Cole G Bradley | COO | Feb 10, 2014 | Option Exercise | $2.88 | 3,000 | 8,640 | 27,789 | Feb 12, 2014, 04:51 PM |
| Cole G Bradley | COO | Feb 10, 2014 | Sale | $27.00 | 3,000 | 81,000 | 24,789 | Feb 12, 2014, 04:51 PM |
| Shak Steven | EVP of R&D | Jan 15, 2014 | Option Exercise | $2.88 | 7,000 | 20,160 | 315,283 | Jan 17, 2014, 01:39 PM |
| Shak Steven | EVP of R&D | Jan 15, 2014 | Sale | $31.51 | 7,000 | 220,601 | 308,283 | Jan 17, 2014, 01:39 PM |
| Popovits Kimberly J | President and CEO | Jan 13, 2014 | Option Exercise | $9.39 | 2,500 | 23,475 | 29,366 | Jan 15, 2014, 10:26 AM |
| Popovits Kimberly J | President and CEO | Jan 13, 2014 | Sale | $30.00 | 2,500 | 75,000 | 26,866 | Jan 15, 2014, 10:26 AM |
| Cole G Bradley | COO | Jan 08, 2014 | Option Exercise | $2.88 | 3,000 | 8,640 | 21,369 | Jan 10, 2014, 03:50 PM |
| Cole G Bradley | COO | Jan 08, 2014 | Sale | $28.17 | 3,000 | 84,501 | 18,369 | Jan 10, 2014, 03:50 PM |
| GRAHAM GINGER L | Director | Jan 01, 2014 | Option Exercise | $29.27 | 341 | 9,981 | 4,221 | Jan 03, 2014, 07:05 PM |
| COLELLA SAMUEL D | Director | Jan 01, 2014 | Option Exercise | $29.27 | 341 | 9,981 | 4,221 | Jan 03, 2014, 07:04 PM |
| Cohen Fred E | Director | Jan 01, 2014 | Option Exercise | $29.27 | 341 | 9,981 | 61,287 | Jan 03, 2014, 07:03 PM |
| BAKER FELIX | Director | Jan 01, 2014 | Option Exercise | $29.27 | 4,092 | 119,773 | 11,243,600 | Jan 03, 2014, 05:29 PM |
| Shak Steven | EVP of R&D & CMO | Dec 17, 2013 | Option Exercise | $2.88 | 7,000 | 20,160 | 315,283 | Dec 18, 2013, 01:45 PM |
| Shak Steven | EVP of R&D & CMO | Dec 16, 2013 | Option Exercise | $2.88 | 7,000 | 20,160 | 315,283 | Dec 18, 2013, 01:45 PM |
| Shak Steven | EVP of R&D & CMO | Dec 17, 2013 | Sale | $29.24 | 7,000 | 204,671 | 308,283 | Dec 18, 2013, 01:45 PM |
| Shak Steven | EVP of R&D & CMO | Dec 16, 2013 | Sale | $29.91 | 7,000 | 209,350 | 308,283 | Dec 18, 2013, 01:45 PM |
| Popovits Kimberly J | President and CEO | Dec 12, 2013 | Option Exercise | $9.39 | 2,500 | 23,475 | 29,366 | Dec 16, 2013, 02:34 PM |
| Popovits Kimberly J | President and CEO | Dec 12, 2013 | Sale | $30.68 | 2,500 | 76,705 | 26,866 | Dec 16, 2013, 02:34 PM |
| Schorno Dean L | CFO | Dec 09, 2013 | Option Exercise | $17.23 | 3,000 | 51,690 | 24,557 | Dec 10, 2013, 04:40 PM |
| Schorno Dean L | CFO | Dec 09, 2013 | Sale | $33.25 | 3,000 | 99,761 | 23,557 | Dec 10, 2013, 04:40 PM |
| LIVINGSTON RANDALL S | Director | Dec 02, 2013 | Option Exercise | $10.73 | 1,000 | 10,730 | 7,149 | Dec 04, 2013, 05:52 PM |
| LIVINGSTON RANDALL S | Director | Dec 02, 2013 | Sale | $34.92 | 1,000 | 34,920 | 6,149 | Dec 04, 2013, 05:52 PM |
| Popovits Kimberly J | President and CEO | Nov 12, 2013 | Option Exercise | $9.39 | 2,500 | 23,475 | 29,366 | Nov 14, 2013, 05:59 PM |
| Popovits Kimberly J | President and CEO | Nov 13, 2013 | Option Exercise | $9.39 | 2,500 | 23,475 | 29,366 | Nov 14, 2013, 05:59 PM |
| Popovits Kimberly J | President and CEO | Nov 13, 2013 | Sale | $35.00 | 2,500 | 87,500 | 26,866 | Nov 14, 2013, 05:59 PM |
| Popovits Kimberly J | President and CEO | Nov 12, 2013 | Sale | $34.17 | 2,500 | 85,423 | 26,866 | Nov 14, 2013, 05:59 PM |
| Schorno Dean L | CFO | Nov 08, 2013 | Option Exercise | $17.33 | 3,000 | 51,990 | 24,436 | Nov 13, 2013, 07:45 PM |
| Schorno Dean L | CFO | Nov 08, 2013 | Sale | $33.36 | 3,000 | 100,090 | 21,436 | Nov 13, 2013, 07:45 PM |
| Cole G Bradley | COO | Nov 06, 2013 | Option Exercise | $1.33 | 2,868 | 3,814 | 21,003 | Nov 08, 2013, 08:37 PM |
| Cole G Bradley | COO | Nov 06, 2013 | Sale | $31.38 | 2,868 | 89,987 | 20,903 | Nov 08, 2013, 08:37 PM |
| Shak Steven | EVP of R&D & CMO | Oct 15, 2013 | Sale | $29.67 | 5,000 | 148,341 | 308,283 | Oct 17, 2013, 05:05 PM |
| Popovits Kimberly J | President and CEO | Oct 10, 2013 | Option Exercise | $4.79 | 2,500 | 11,978 | 29,366 | Oct 15, 2013, 06:23 PM |
| Popovits Kimberly J | President and CEO | Oct 10, 2013 | Sale | $30.00 | 2,500 | 75,000 | 26,866 | Oct 15, 2013, 06:23 PM |
| Cole G Bradley | COO | Oct 09, 2013 | Option Exercise | $1.33 | 2,500 | 3,325 | 20,635 | Oct 11, 2013, 04:50 PM |
| Cole G Bradley | COO | Oct 09, 2013 | Sale | $29.95 | 2,500 | 74,885 | 18,135 | Oct 11, 2013, 04:50 PM |
| MYERS WOODROW A JR | Director | Oct 01, 2013 | Option Exercise | $30.33 | 329 | 9,979 | 3,880 | Oct 03, 2013, 08:12 PM |
| GRAHAM GINGER L | Director | Oct 01, 2013 | Option Exercise | $30.33 | 329 | 9,979 | 3,880 | Oct 03, 2013, 08:11 PM |
| COLELLA SAMUEL D | Director | Oct 01, 2013 | Option Exercise | $30.33 | 329 | 9,979 | 3,880 | Oct 03, 2013, 08:09 PM |
| Cohen Fred E | Director | Oct 01, 2013 | Option Exercise | $30.33 | 329 | 9,979 | 60,946 | Oct 03, 2013, 08:07 PM |
| BAKER FELIX | Director | Oct 01, 2013 | Option Exercise | $30.33 | 3,948 | 119,743 | 11,242,918 | Oct 02, 2013, 05:27 PM |
| Shak Steven | EVP of R&D & CMO | Sep 18, 2013 | Sale | $33.73 | 5,000 | 168,629 | 313,283 | Sep 20, 2013, 05:38 PM |
| Popovits Kimberly J | President and CEO | Sep 12, 2013 | Option Exercise | $2.88 | 2,500 | 7,200 | 29,366 | Sep 16, 2013, 05:05 PM |
| Popovits Kimberly J | President and CEO | Sep 12, 2013 | Sale | $34.31 | 2,500 | 85,787 | 26,866 | Sep 16, 2013, 05:05 PM |
| Cole G Bradley | COO | Sep 09, 2013 | Option Exercise | $1.33 | 2,500 | 3,325 | 21,635 | Sep 11, 2013, 04:05 PM |
| Cole G Bradley | COO | Sep 09, 2013 | Sale | $32.53 | 2,500 | 81,329 | 19,135 | Sep 11, 2013, 04:05 PM |
| Schorno Dean L | CFO | Sep 06, 2013 | Option Exercise | $17.29 | 4,000 | 69,178 | 24,486 | Sep 10, 2013, 08:20 PM |
| Schorno Dean L | CFO | Sep 06, 2013 | Sale | $32.90 | 4,000 | 131,600 | 21,436 | Sep 10, 2013, 08:20 PM |
| LIVINGSTON RANDALL S | Director | Sep 03, 2013 | Option Exercise | $10.73 | 1,000 | 10,730 | 7,149 | Sep 04, 2013, 05:51 PM |
| LIVINGSTON RANDALL S | Director | Sep 03, 2013 | Sale | $31.49 | 1,000 | 31,492 | 6,149 | Sep 04, 2013, 05:51 PM |
| Shak Steven | EVP of R&D & CMO | Aug 14, 2013 | Sale | $32.98 | 5,000 | 164,905 | 318,283 | Aug 16, 2013, 07:24 PM |
| Schorno Dean L | CFO | Aug 09, 2013 | Option Exercise | $17.18 | 4,000 | 68,720 | 25,436 | Aug 15, 2013, 08:19 PM |
| Schorno Dean L | CFO | Aug 09, 2013 | Sale | $33.15 | 4,000 | 132,581 | 21,436 | Aug 15, 2013, 08:19 PM |
| Schorno Dean L | CFO | Jul 09, 2013 | Option Exercise | $17.22 | 4,000 | 68,885 | 20,734 | Aug 15, 2013, 08:17 PM |
| Schorno Dean L | CFO | Jul 09, 2013 | Sale | $33.81 | 4,000 | 135,237 | 17,836 | Aug 15, 2013, 08:17 PM |
| Popovits Kimberly J | President and CEO | Aug 12, 2013 | Option Exercise | $2.88 | 2,500 | 7,200 | 29,366 | Aug 14, 2013, 05:29 PM |
| Popovits Kimberly J | President and CEO | Aug 12, 2013 | Sale | $33.03 | 2,500 | 82,572 | 26,866 | Aug 14, 2013, 05:29 PM |
| Schorno Dean L | CFO | Aug 09, 2013 | Option Exercise | $17.18 | 4,000 | 68,720 | 25,436 | Aug 12, 2013, 08:48 PM |
| Schorno Dean L | CFO | Aug 09, 2013 | Sale | $33.15 | 4,000 | 132,581 | 21,436 | Aug 12, 2013, 08:48 PM |
| Cole G Bradley | COO | Aug 07, 2013 | Option Exercise | $1.33 | 2,500 | 3,325 | 21,635 | Aug 09, 2013, 05:16 PM |
| Cole G Bradley | COO | Aug 07, 2013 | Sale | $33.66 | 2,500 | 84,140 | 19,135 | Aug 09, 2013, 05:16 PM |
| Shak Steven | EVP of R&D & CMO | Jul 23, 2013 | Sale | $35.33 | 5,000 | 176,670 | 318,283 | Jul 26, 2013, 02:05 PM |
| Popovits Kimberly J | President and CEO | Jul 12, 2013 | Option Exercise | $2.88 | 2,100 | 6,048 | 19,966 | Jul 15, 2013, 07:57 PM |
| Popovits Kimberly J | President and CEO | Jul 11, 2013 | Option Exercise | $2.88 | 2,900 | 8,352 | 20,766 | Jul 15, 2013, 07:57 PM |
| Popovits Kimberly J | President and CEO | Jul 11, 2013 | Sale | $34.32 | 2,900 | 99,528 | 17,866 | Jul 15, 2013, 07:57 PM |
| Popovits Kimberly J | President and CEO | Jul 12, 2013 | Sale | $35.00 | 2,100 | 73,500 | 17,866 | Jul 15, 2013, 07:57 PM |
| Schorno Dean L | CFO | Jul 09, 2013 | Option Exercise | $17.33 | 4,000 | 69,320 | 21,836 | Jul 10, 2013, 07:47 PM |
| Schorno Dean L | CFO | Jul 09, 2013 | Sale | $33.81 | 4,000 | 135,237 | 17,836 | Jul 10, 2013, 07:47 PM |
| Cole G Bradley | COO | Jul 08, 2013 | Option Exercise | $1.33 | 2,500 | 3,325 | 15,635 | Jul 10, 2013, 07:45 PM |
| Cole G Bradley | COO | Jul 08, 2013 | Sale | $33.33 | 2,500 | 83,327 | 13,135 | Jul 10, 2013, 07:45 PM |
| BAKER FELIX | Director | Jul 01, 2013 | Option Exercise | $32.85 | 3,636 | 119,443 | 11,242,260 | Jul 03, 2013, 05:25 PM |
| MYERS WOODROW A JR | Director | Jul 01, 2013 | Option Exercise | $32.85 | 303 | 9,954 | 3,551 | Jul 03, 2013, 05:17 PM |
| GRAHAM GINGER L | Director | Jul 01, 2013 | Option Exercise | $32.85 | 303 | 9,954 | 3,551 | Jul 03, 2013, 05:16 PM |
| COLELLA SAMUEL D | Director | Jul 01, 2013 | Option Exercise | $32.85 | 303 | 9,954 | 3,551 | Jul 03, 2013, 05:15 PM |
| Cohen Fred E | Director | Jul 01, 2013 | Option Exercise | $32.85 | 303 | 9,954 | 60,617 | Jul 03, 2013, 05:14 PM |
| Shak Steven | EVP of R&D & CMO | Jun 18, 2013 | Sale | $33.52 | 5,000 | 167,605 | 326,783 | Jun 19, 2013, 05:32 PM |
| Popovits Kimberly J | President and CEO | Jun 12, 2013 | Option Exercise | $2.88 | 5,000 | 14,400 | 20,366 | Jun 14, 2013, 04:39 PM |
| Popovits Kimberly J | President and CEO | Jun 12, 2013 | Sale | $35.68 | 5,000 | 178,399 | 17,866 | Jun 14, 2013, 04:39 PM |
| Schorno Dean L | CFO | Jun 10, 2013 | Option Exercise | $17.33 | 4,000 | 69,320 | 21,836 | Jun 12, 2013, 08:28 PM |
| Schorno Dean L | CFO | Jun 10, 2013 | Sale | $35.88 | 4,000 | 143,525 | 17,836 | Jun 12, 2013, 08:28 PM |
| Cole G Bradley | COO | Jun 05, 2013 | Option Exercise | $1.33 | 2,500 | 3,325 | 15,635 | Jun 07, 2013, 05:34 PM |
| Cole G Bradley | COO | Jun 05, 2013 | Sale | $36.47 | 2,500 | 91,172 | 13,135 | Jun 07, 2013, 05:34 PM |
| BAKER FELIX | Director | Jun 05, 2013 | Buy | $35.81 | 194,621 | 6,970,351 | 11,241,654 | Jun 05, 2013, 05:23 PM |
| BAKER FELIX | Director | Jun 05, 2013 | Buy | $35.81 | 23,152 | 829,189 | 1,730,777 | Jun 05, 2013, 05:23 PM |
| BAKER FELIX | Director | Jun 04, 2013 | Buy | $36.62 | 163,659 | 5,993,192 | 11,051,768 | Jun 05, 2013, 05:23 PM |
| LIVINGSTON RANDALL S | Director | Jun 03, 2013 | Option Exercise | $10.73 | 1,000 | 10,730 | 7,149 | Jun 04, 2013, 07:03 PM |
| LIVINGSTON RANDALL S | Director | Jun 03, 2013 | Sale | $36.40 | 1,000 | 36,400 | 6,149 | Jun 04, 2013, 07:03 PM |
| BAKER FELIX | Director | Jun 03, 2013 | Buy | $36.69 | 114,697 | 4,207,877 | 10,909,066 | Jun 03, 2013, 05:40 PM |
| BAKER FELIX | Director | Jun 03, 2013 | Buy | $36.69 | 13,644 | 500,556 | 1,690,226 | Jun 03, 2013, 05:40 PM |
| BAKER FELIX | Director | May 31, 2013 | Buy | $36.75 | 51,242 | 1,883,256 | 10,797,159 | Jun 03, 2013, 05:40 PM |
| BAKER FELIX | Director | May 29, 2013 | Buy | $36.82 | 41,954 | 1,544,813 | 10,752,532 | May 29, 2013, 06:06 PM |
| BAKER FELIX | Director | May 29, 2013 | Buy | $36.82 | 5,046 | 185,802 | 1,671,081 | May 29, 2013, 06:06 PM |
| BAKER FELIX | Director | May 28, 2013 | Buy | $36.93 | 74,266 | 2,742,933 | 10,711,599 | May 29, 2013, 06:06 PM |
| BAKER FELIX | Director | May 24, 2013 | Buy | $36.93 | 62,517 | 2,308,909 | 10,646,920 | May 24, 2013, 05:04 PM |
| BAKER FELIX | Director | May 23, 2013 | Buy | $36.99 | 13,645 | 504,693 | 10,592,521 | May 24, 2013, 05:04 PM |
| BAKER FELIX | Director | May 23, 2013 | Buy | $36.59 | 3,255 | 119,106 | 10,579,208 | May 24, 2013, 05:04 PM |
| HIBBS KATHY L | SVP & General Counsel | May 22, 2013 | Option Exercise | $21.07 | 1,000 | 21,070 | 8,087 | May 23, 2013, 05:24 PM |
| HIBBS KATHY L | SVP & General Counsel | May 22, 2013 | Sale | $37.48 | 1,000 | 37,480 | 7,087 | May 23, 2013, 05:24 PM |
| Shak Steven | EVP of R&D & CMO | May 21, 2013 | Sale | $37.19 | 5,000 | 185,957 | 327,380 | May 22, 2013, 07:54 PM |
| LIVINGSTON RANDALL S | Director | May 15, 2013 | Option Exercise | $1.33 | 1,337 | 1,774 | 7,486 | May 17, 2013, 05:33 PM |
| LIVINGSTON RANDALL S | Director | May 15, 2013 | Sale | $35.83 | 1,337 | 47,904 | 6,149 | May 17, 2013, 05:33 PM |
| BAKER FELIX | Director | May 15, 2013 | Buy | $36.41 | 52,133 | 1,898,361 | 10,561,048 | May 16, 2013, 06:03 PM |
| BAKER FELIX | Director | May 16, 2013 | Buy | $36.54 | 17,186 | 627,963 | 10,577,816 | May 16, 2013, 06:03 PM |
| BAKER FELIX | Director | May 16, 2013 | Buy | $36.54 | 2,120 | 77,463 | 1,649,473 | May 16, 2013, 06:03 PM |
| HIBBS KATHY L | SVP & General Counsel | May 13, 2013 | Option Exercise | $21.07 | 1,250 | 26,337 | 8,337 | May 15, 2013, 06:10 PM |
| HIBBS KATHY L | SVP & General Counsel | May 13, 2013 | Sale | $34.42 | 1,250 | 43,031 | 7,087 | May 15, 2013, 06:10 PM |
| Popovits Kimberly J | President and CEO | May 13, 2013 | Option Exercise | $2.88 | 5,000 | 14,400 | 19,463 | May 15, 2013, 06:08 PM |
| Popovits Kimberly J | President and CEO | May 13, 2013 | Sale | $34.70 | 5,000 | 173,506 | 16,963 | May 15, 2013, 06:08 PM |
| BAKER FELIX | Director | May 13, 2013 | Buy | $34.02 | 144,478 | 4,914,910 | 10,492,159 | May 14, 2013, 06:40 PM |
| BAKER FELIX | Director | May 13, 2013 | Buy | $34.56 | 68,764 | 2,376,256 | 10,351,197 | May 14, 2013, 06:40 PM |
| BAKER FELIX | Director | May 14, 2013 | Buy | $35.53 | 27,184 | 965,899 | 10,515,769 | May 14, 2013, 06:40 PM |
| Schorno Dean L | CFO | May 09, 2013 | Option Exercise | $17.18 | 4,000 | 68,720 | 21,092 | May 13, 2013, 05:33 PM |
| Schorno Dean L | CFO | May 09, 2013 | Sale | $36.02 | 4,000 | 144,088 | 17,092 | May 13, 2013, 05:33 PM |
| Cole G Bradley | COO | May 08, 2013 | Option Exercise | $1.33 | 2,500 | 3,325 | 15,040 | May 09, 2013, 03:16 PM |
| Cole G Bradley | COO | May 08, 2013 | Sale | $35.99 | 2,500 | 89,964 | 12,540 | May 09, 2013, 03:16 PM |
| Popovits Kimberly J | President and CEO | Apr 23, 2013 | Option Exercise | $2.88 | 2,500 | 7,200 | 19,463 | Apr 25, 2013, 05:55 PM |
| Popovits Kimberly J | President and CEO | Apr 23, 2013 | Sale | $30.00 | 2,500 | 75,000 | 16,963 | Apr 25, 2013, 05:55 PM |
| Cole G Bradley | COO | Apr 03, 2013 | Option Exercise | $1.33 | 2,500 | 3,325 | 15,040 | Apr 05, 2013, 05:50 PM |
| Cole G Bradley | COO | Apr 03, 2013 | Sale | $27.79 | 2,500 | 69,483 | 12,540 | Apr 05, 2013, 05:50 PM |
| BAKER FELIX | Director | Apr 01, 2013 | Option Exercise | $27.99 | 4,284 | 119,909 | 10,306,953 | Apr 03, 2013, 05:50 PM |
| GRAHAM GINGER L | Director | Apr 01, 2013 | Option Exercise | $27.99 | 357 | 9,992 | 3,248 | Apr 03, 2013, 04:56 PM |
| Cohen Fred E | Director | Apr 01, 2013 | Option Exercise | $27.99 | 357 | 9,992 | 60,314 | Apr 03, 2013, 04:55 PM |
| COLELLA SAMUEL D | Director | Apr 01, 2013 | Option Exercise | $27.99 | 357 | 9,992 | 3,248 | Apr 03, 2013, 04:54 PM |
| MYERS WOODROW A JR | Director | Apr 01, 2013 | Option Exercise | $27.99 | 357 | 9,992 | 3,248 | Apr 03, 2013, 04:53 PM |
| Cole G Bradley | COO | Mar 06, 2013 | Option Exercise | $1.33 | 2,500 | 3,325 | 15,040 | Mar 08, 2013, 04:14 PM |
| Cole G Bradley | COO | Mar 06, 2013 | Sale | $28.57 | 2,500 | 71,435 | 12,540 | Mar 08, 2013, 04:14 PM |
| HIBBS KATHY L | SVP & General Counsel | Feb 20, 2013 | Sale | $28.13 | 2,716 | 76,399 | 7,087 | Feb 22, 2013, 07:50 PM |
| BAKER FELIX | Director | Feb 21, 2013 | Buy | $27.64 | 3,080 | 85,122 | 1,614,513 | Feb 21, 2013, 06:11 PM |
| BAKER FELIX | Director | Feb 20, 2013 | Buy | $27.97 | 20,885 | 584,220 | 10,281,731 | Feb 21, 2013, 06:11 PM |
| BAKER FELIX | Director | Feb 21, 2013 | Buy | $27.64 | 25,120 | 694,237 | 10,306,239 | Feb 21, 2013, 06:11 PM |
| Popovits Kimberly J | President and CEO | Feb 15, 2013 | Option Exercise | $28.77 | 2,560 | 73,651 | 18,207 | Feb 20, 2013, 07:45 PM |
| Cole G Bradley | COO | Feb 15, 2013 | Option Exercise | $28.77 | 1,819 | 52,333 | 13,239 | Feb 20, 2013, 07:33 PM |
| Shak Steven | EVP of R&D & CMO | Feb 15, 2013 | Option Exercise | $28.77 | 1,388 | 39,933 | 333,211 | Feb 20, 2013, 07:27 PM |
| Schorno Dean L | CFO | Feb 15, 2013 | Option Exercise | $28.77 | 1,141 | 32,827 | 16,799 | Feb 20, 2013, 07:22 PM |
| HIBBS KATHY L | SVP & General Counsel | Feb 15, 2013 | Option Exercise | $28.77 | 1,850 | 53,225 | 10,495 | Feb 20, 2013, 07:19 PM |
| MYERS WOODROW A JR | Director | Feb 14, 2013 | Option Exercise | $18.88 | 41,250 | 778,635 | 44,141 | Feb 15, 2013, 07:32 PM |
| MYERS WOODROW A JR | Director | Feb 14, 2013 | Sale | $28.40 | 41,250 | 1,171,529 | 2,891 | Feb 15, 2013, 07:32 PM |
| BAKER FELIX | Director | Feb 14, 2013 | Buy | $28.43 | 30,860 | 877,384 | 10,263,580 | Feb 14, 2013, 05:51 PM |
| BAKER FELIX | Director | Feb 14, 2013 | Buy | $28.43 | 3,940 | 112,019 | 1,609,152 | Feb 14, 2013, 05:51 PM |
| BAKER FELIX | Director | Feb 13, 2013 | Buy | $28.58 | 17,200 | 491,585 | 10,233,478 | Feb 14, 2013, 05:51 PM |
| BAKER FELIX | Director | Feb 11, 2013 | Buy | $28.23 | 9,055 | 255,638 | 1,603,265 | Feb 11, 2013, 06:43 PM |
| BAKER FELIX | Director | Feb 08, 2013 | Buy | $27.96 | 36,376 | 1,017,106 | 10,149,413 | Feb 11, 2013, 06:43 PM |
| BAKER FELIX | Director | Feb 11, 2013 | Buy | $28.23 | 70,929 | 2,002,446 | 10,218,600 | Feb 11, 2013, 06:43 PM |
| Cole G Bradley | COO | Feb 06, 2013 | Option Exercise | $1.33 | 2,500 | 3,325 | 16,585 | Feb 07, 2013, 05:02 PM |
| Cole G Bradley | COO | Feb 06, 2013 | Sale | $28.03 | 2,500 | 70,076 | 14,085 | Feb 07, 2013, 05:02 PM |
| LIVINGSTON RANDALL S | Director | Jan 28, 2013 | Option Exercise | $1.33 | 2,000 | 2,653 | 8,149 | Jan 29, 2013, 05:22 PM |
| LIVINGSTON RANDALL S | Director | Jan 28, 2013 | Sale | $28.77 | 2,000 | 57,543 | 6,149 | Jan 29, 2013, 05:22 PM |
| Schorno Dean L | CFO | Jan 09, 2013 | Option Exercise | $9.39 | 2,625 | 24,649 | 19,980 | Jan 11, 2013, 07:31 PM |
| Schorno Dean L | CFO | Jan 09, 2013 | Sale | $28.00 | 2,625 | 73,500 | 17,355 | Jan 11, 2013, 07:31 PM |
| Cole G Bradley | COO | Jan 09, 2013 | Option Exercise | $1.33 | 2,500 | 3,325 | 16,585 | Jan 11, 2013, 07:29 PM |
| Cole G Bradley | COO | Jan 09, 2013 | Sale | $27.88 | 2,500 | 69,694 | 14,085 | Jan 11, 2013, 07:29 PM |
| BAKER FELIX | Director | Jan 01, 2013 | Option Exercise | $27.24 | 2,202 | 59,982 | 10,117,829 | Jan 03, 2013, 08:14 PM |
| MYERS WOODROW A JR | Director | Jan 01, 2013 | Option Exercise | $27.24 | 367 | 9,997 | 2,891 | Jan 03, 2013, 05:10 PM |
| GRAHAM GINGER L | Director | Jan 01, 2013 | Option Exercise | $27.24 | 367 | 9,997 | 2,891 | Jan 03, 2013, 05:09 PM |
| COLELLA SAMUEL D | Director | Jan 01, 2013 | Option Exercise | $27.24 | 367 | 9,997 | 2,891 | Jan 03, 2013, 05:08 PM |
| Cohen Fred E | Director | Jan 01, 2013 | Option Exercise | $27.24 | 367 | 9,997 | 59,957 | Jan 03, 2013, 05:06 PM |
| Shak Steven | EVP of R&D & CMO | Dec 18, 2012 | Sale | $27.74 | 5,000 | 138,721 | 333,768 | Dec 19, 2012, 07:02 PM |
| Popovits Kimberly J | President and CEO | Dec 13, 2012 | Sale | $27.79 | 5,000 | 138,955 | 208,806 | Dec 14, 2012, 05:26 PM |
| Schorno Dean L | CFO | Dec 11, 2012 | Option Exercise | $9.39 | 3,000 | 28,170 | 20,355 | Dec 12, 2012, 05:37 PM |
| Schorno Dean L | CFO | Dec 11, 2012 | Sale | $28.00 | 3,000 | 84,000 | 17,355 | Dec 12, 2012, 05:37 PM |
| Cole G Bradley | COO | Dec 06, 2012 | Option Exercise | $1.33 | 2,500 | 3,325 | 16,585 | Dec 07, 2012, 06:50 PM |
| Cole G Bradley | COO | Dec 06, 2012 | Sale | $27.18 | 2,500 | 67,947 | 14,085 | Dec 07, 2012, 06:50 PM |
| LIVINGSTON RANDALL S | Director | Nov 26, 2012 | Option Exercise | $1.33 | 2,000 | 2,653 | 8,149 | Nov 27, 2012, 05:05 PM |
| LIVINGSTON RANDALL S | Director | Nov 26, 2012 | Sale | $27.84 | 2,000 | 55,683 | 6,149 | Nov 27, 2012, 05:05 PM |
| BAKER FELIX | Director | Nov 21, 2012 | Buy | $27.54 | 300 | 8,262 | 10,117,174 | Nov 23, 2012, 01:24 PM |
| BAKER FELIX | Director | Nov 20, 2012 | Buy | $26.83 | 229,000 | 6,143,360 | 10,116,906 | Nov 23, 2012, 01:24 PM |
| Shak Steven | EVP of R&D & CMO | Nov 20, 2012 | Sale | $26.94 | 5,000 | 134,710 | 339,067 | Nov 21, 2012, 05:36 PM |
| COLELLA SAMUEL D | Director | Nov 20, 2012 | Sale | $26.52 | 3,629 | 96,232 | 0 | Nov 20, 2012, 07:51 PM |
| COLELLA SAMUEL D | Director | Nov 20, 2012 | Sale | $26.52 | 1,871 | 49,614 | 0 | Nov 20, 2012, 07:51 PM |
| COLELLA SAMUEL D | Director | Nov 19, 2012 | Sale | $26.97 | 16,573 | 447,043 | 3,629 | Nov 20, 2012, 07:51 PM |
| COLELLA SAMUEL D | Director | Nov 19, 2012 | Sale | $26.97 | 8,543 | 230,441 | 1,871 | Nov 20, 2012, 07:51 PM |
| Popovits Kimberly J | President and CEO | Nov 14, 2012 | Sale | $27.24 | 5,000 | 136,217 | 213,406 | Nov 16, 2012, 06:20 PM |
| BAKER FELIX | Director | Nov 14, 2012 | Buy | $27.32 | 103,167 | 2,818,161 | 9,914,595 | Nov 14, 2012, 09:16 PM |
| BAKER FELIX | Director | Nov 13, 2012 | Buy | $27.99 | 103,839 | 2,906,651 | 9,822,003 | Nov 14, 2012, 09:05 PM |
| BAKER FELIX | Director | Nov 12, 2012 | Buy | $27.94 | 200,000 | 5,587,480 | 9,729,086 | Nov 14, 2012, 09:05 PM |
| BAKER FELIX | Director | Nov 09, 2012 | Buy | $27.72 | 519,933 | 14,414,195 | 9,550,108 | Nov 14, 2012, 09:05 PM |
| Schorno Dean L | CFO | Nov 12, 2012 | Option Exercise | $9.39 | 2,800 | 26,292 | 20,155 | Nov 14, 2012, 03:38 PM |
| Schorno Dean L | CFO | Nov 09, 2012 | Option Exercise | $9.39 | 200 | 1,878 | 17,555 | Nov 14, 2012, 03:38 PM |
| Schorno Dean L | CFO | Nov 12, 2012 | Sale | $28.00 | 2,800 | 78,400 | 17,355 | Nov 14, 2012, 03:38 PM |
| Schorno Dean L | CFO | Nov 09, 2012 | Sale | $28.00 | 200 | 5,600 | 17,355 | Nov 14, 2012, 03:38 PM |
| Cole G Bradley | COO | Nov 08, 2012 | Option Exercise | $1.33 | 2,500 | 3,325 | 16,585 | Nov 13, 2012, 06:43 PM |
| Cole G Bradley | COO | Nov 08, 2012 | Sale | $28.62 | 2,500 | 71,542 | 14,085 | Nov 13, 2012, 06:43 PM |
| Shak Steven | EVP of R&D & CMO | Oct 16, 2012 | Sale | $35.25 | 5,000 | 176,254 | 348,434 | Oct 18, 2012, 06:38 PM |
| Popovits Kimberly J | President and CEO | Oct 16, 2012 | Option Exercise | $23.31 | 5,000 | 116,550 | 24,523 | Oct 17, 2012, 05:59 PM |
| Popovits Kimberly J | President and CEO | Oct 16, 2012 | Sale | $35.00 | 5,000 | 175,000 | 19,523 | Oct 17, 2012, 05:59 PM |
| Popovits Kimberly J | President and CEO | Oct 15, 2012 | Sale | $31.17 | 5,000 | 155,838 | 218,406 | Oct 17, 2012, 05:59 PM |
| Schorno Dean L | CFO | Oct 12, 2012 | Option Exercise | $9.39 | 3,000 | 28,170 | 20,355 | Oct 16, 2012, 05:44 PM |
| Schorno Dean L | CFO | Oct 12, 2012 | Sale | $33.79 | 3,000 | 101,358 | 17,355 | Oct 16, 2012, 05:44 PM |
| HIBBS KATHY L | SVP & General Counsel | Oct 11, 2012 | Option Exercise | $21.07 | 1,250 | 26,337 | 12,617 | Oct 15, 2012, 05:48 PM |
| HIBBS KATHY L | SVP & General Counsel | Oct 11, 2012 | Sale | $33.78 | 1,250 | 42,224 | 11,367 | Oct 15, 2012, 05:48 PM |
| Cole G Bradley | COO | Oct 09, 2012 | Option Exercise | $1.33 | 2,500 | 3,325 | 16,585 | Oct 11, 2012, 05:51 PM |
| Cole G Bradley | COO | Oct 09, 2012 | Sale | $34.80 | 2,500 | 86,990 | 14,085 | Oct 11, 2012, 05:51 PM |
| MYERS WOODROW A JR | Director | Oct 01, 2012 | Option Exercise | $35.89 | 288 | 10,336 | 2,524 | Oct 03, 2012, 06:58 PM |
| GRAHAM GINGER L | Director | Oct 01, 2012 | Option Exercise | $35.89 | 288 | 10,336 | 2,524 | Oct 03, 2012, 06:47 PM |
| Cohen Fred E | Director | Oct 01, 2012 | Option Exercise | $35.89 | 288 | 10,336 | 59,590 | Oct 03, 2012, 06:44 PM |
| COLELLA SAMUEL D | Director | Oct 01, 2012 | Option Exercise | $35.89 | 288 | 10,336 | 2,524 | Oct 03, 2012, 06:43 PM |
| BAKER FELIX | Director | Oct 01, 2012 | Option Exercise | $35.89 | 288 | 10,336 | 288 | Oct 03, 2012, 05:59 PM |
| Shak Steven | EVP of R&D & CMO | Sep 18, 2012 | Sale | $33.76 | 5,000 | 168,800 | 348,768 | Sep 19, 2012, 05:44 PM |
| Popovits Kimberly J | President and CEO | Sep 13, 2012 | Sale | $31.69 | 5,000 | 158,450 | 223,406 | Sep 17, 2012, 07:32 PM |
| Cole G Bradley | COO | Sep 06, 2012 | Option Exercise | $1.33 | 2,500 | 3,325 | 16,585 | Sep 10, 2012, 05:43 PM |
| Cole G Bradley | COO | Sep 06, 2012 | Sale | $35.01 | 2,500 | 87,514 | 14,085 | Sep 10, 2012, 05:43 PM |
| Cohen Fred E | Director | Aug 01, 2012 | Option Exercise | $10.73 | 8,250 | 88,522 | 59,302 | Aug 31, 2012, 05:38 PM |
| MYERS WOODROW A JR | Director | Aug 20, 2012 | Option Exercise | $9.95 | 5,507 | 54,795 | 7,743 | Aug 22, 2012, 06:31 PM |
| MYERS WOODROW A JR | Director | Aug 21, 2012 | Option Exercise | $9.95 | 10,993 | 109,380 | 13,229 | Aug 22, 2012, 06:31 PM |
| MYERS WOODROW A JR | Director | Aug 20, 2012 | Sale | $35.06 | 5,507 | 193,061 | 2,236 | Aug 22, 2012, 06:31 PM |
| MYERS WOODROW A JR | Director | Aug 21, 2012 | Sale | $35.28 | 10,993 | 387,803 | 2,236 | Aug 22, 2012, 06:31 PM |
| Shak Steven | EVP of R&D & CMO | Aug 20, 2012 | Sale | $34.99 | 5,000 | 174,939 | 353,768 | Aug 22, 2012, 06:29 PM |
| Popovits Kimberly J | President and CEO | Aug 13, 2012 | Option Exercise | $23.31 | 1,897 | 44,219 | 21,420 | Aug 15, 2012, 03:12 PM |
| Popovits Kimberly J | President and CEO | Aug 14, 2012 | Option Exercise | $23.31 | 3,103 | 72,331 | 22,626 | Aug 15, 2012, 03:12 PM |
| Popovits Kimberly J | President and CEO | Aug 13, 2012 | Sale | $35.01 | 1,897 | 66,412 | 19,523 | Aug 15, 2012, 03:12 PM |
| Popovits Kimberly J | President and CEO | Aug 13, 2012 | Sale | $34.39 | 5,000 | 171,936 | 228,406 | Aug 15, 2012, 03:12 PM |
| Popovits Kimberly J | President and CEO | Aug 14, 2012 | Sale | $35.07 | 3,103 | 108,814 | 19,523 | Aug 15, 2012, 03:12 PM |
| Cole G Bradley | COO | Aug 08, 2012 | Option Exercise | $1.33 | 2,500 | 3,325 | 16,585 | Aug 09, 2012, 04:38 PM |
| Cole G Bradley | COO | Aug 08, 2012 | Sale | $30.49 | 2,500 | 76,236 | 14,085 | Aug 09, 2012, 04:38 PM |
| LIVINGSTON RANDALL S | Director | Jul 26, 2012 | Option Exercise | $1.33 | 2,000 | 2,653 | 8,149 | Jul 27, 2012, 05:51 PM |
| LIVINGSTON RANDALL S | Director | Jul 26, 2012 | Sale | $35.90 | 2,000 | 71,800 | 6,149 | Jul 27, 2012, 05:51 PM |
| Shak Steven | Chief Medical Officer | Jul 24, 2012 | Sale | $34.24 | 5,000 | 171,196 | 358,768 | Jul 25, 2012, 11:10 AM |
| Popovits Kimberly J | President and CEO | Jul 13, 2012 | Option Exercise | $23.31 | 2,100 | 48,951 | 21,623 | Jul 17, 2012, 05:57 PM |
| Popovits Kimberly J | President and CEO | Jul 13, 2012 | Sale | $34.64 | 5,000 | 173,207 | 233,406 | Jul 17, 2012, 05:57 PM |
| Popovits Kimberly J | President and CEO | Jul 13, 2012 | Sale | $35.03 | 2,100 | 73,570 | 19,523 | Jul 17, 2012, 05:57 PM |
| Scott Randal W | CEO, InVitae Corporation* | Jul 11, 2012 | Sale | $34.81 | 15,000 | 522,134 | 1,185,417 | Jul 12, 2012, 02:42 PM |
| Scott Randal W | CEO, InVitae Corporation* | Jul 10, 2012 | Sale | $35.97 | 15,000 | 539,537 | 1,200,317 | Jul 12, 2012, 02:42 PM |
| Cole G Bradley | COO | Jul 05, 2012 | Option Exercise | $1.33 | 2,500 | 3,325 | 16,585 | Jul 06, 2012, 02:16 PM |
| Cole G Bradley | COO | Jul 05, 2012 | Sale | $35.95 | 2,500 | 89,864 | 14,085 | Jul 06, 2012, 02:16 PM |
| COLELLA SAMUEL D | Director | Jul 01, 2012 | Option Exercise | $33.40 | 299 | 9,987 | 2,236 | Jul 03, 2012, 07:27 PM |
| Cohen Fred E | Director | Jul 01, 2012 | Option Exercise | $33.40 | 299 | 9,987 | 51,052 | Jul 03, 2012, 07:23 PM |
| GRAHAM GINGER L | Director | Jul 01, 2012 | Option Exercise | $33.40 | 299 | 9,987 | 2,236 | Jul 03, 2012, 07:21 PM |
| MYERS WOODROW A JR | Director | Jul 01, 2012 | Option Exercise | $33.40 | 299 | 9,987 | 2,236 | Jul 03, 2012, 07:01 PM |
| Shak Steven | Chief Medical Officer | Jun 25, 2012 | Sale | $33.25 | 5,000 | 166,252 | 363,768 | Jun 27, 2012, 07:05 PM |
| Popovits Kimberly J | President and CEO | Jun 13, 2012 | Sale | $33.36 | 5,000 | 166,805 | 238,406 | Jun 19, 2012, 07:50 PM |
| Popovits Kimberly J | President and CEO | May 31, 2012 | Buy | $23.11 | 919 | 21,239 | 19,523 | Jun 15, 2012, 05:27 PM |
| Popovits Kimberly J | President and CEO | Jun 13, 2012 | Sale | $33.36 | 5,000 | 166,805 | 238,406 | Jun 15, 2012, 05:27 PM |
| Scott Randal W | CEO, InVitae Corporation* | Jun 12, 2012 | Sale | $33.31 | 15,000 | 499,654 | 1,215,117 | Jun 13, 2012, 02:46 PM |
| Scott Randal W | CEO, InVitae Corporation* | Jun 11, 2012 | Sale | $33.77 | 15,000 | 506,562 | 1,230,717 | Jun 13, 2012, 02:46 PM |
| Cole G Bradley | COO | Jun 06, 2012 | Option Exercise | $1.33 | 2,500 | 3,325 | 16,007 | Jun 08, 2012, 02:39 PM |
| Cole G Bradley | COO | Jun 06, 2012 | Sale | $33.97 | 2,500 | 84,919 | 13,507 | Jun 08, 2012, 02:39 PM |
| Shak Steven | Chief Medical Officer | May 24, 2012 | Sale | $33.80 | 5,000 | 168,979 | 367,849 | May 29, 2012, 05:44 PM |
| BAKER JULIAN | Director | May 22, 2012 | Buy | $32.94 | 17,406 | 573,401 | 9,086,690 | May 23, 2012, 05:03 PM |
| BAKER JULIAN | Director | May 21, 2012 | Buy | $32.18 | 150,000 | 4,826,972 | 9,069,664 | May 23, 2012, 05:03 PM |
| COLELLA SAMUEL D | Director | May 18, 2012 | Sale | $32.13 | 6,137 | 197,168 | 20,202 | May 18, 2012, 06:21 PM |
| COLELLA SAMUEL D | Director | May 18, 2012 | Sale | $32.13 | 3,163 | 101,620 | 10,414 | May 18, 2012, 06:21 PM |
| COLELLA SAMUEL D | Director | May 17, 2012 | Sale | $33.52 | 11,213 | 375,888 | 26,339 | May 18, 2012, 06:21 PM |
| COLELLA SAMUEL D | Director | May 17, 2012 | Sale | $33.52 | 5,781 | 193,794 | 13,577 | May 18, 2012, 06:21 PM |
| Popovits Kimberly J | President and CEO | May 16, 2012 | Option Exercise | $23.31 | 5,000 | 116,550 | 250,656 | May 17, 2012, 05:39 PM |
| Popovits Kimberly J | President and CEO | May 15, 2012 | Sale | $33.46 | 5,000 | 167,292 | 245,656 | May 17, 2012, 05:39 PM |
| Popovits Kimberly J | President and CEO | May 16, 2012 | Sale | $35.00 | 5,000 | 175,000 | 245,656 | May 17, 2012, 05:39 PM |
| Schorno Dean L | CFO | May 15, 2012 | Sale | $33.69 | 1,000 | 33,686 | 17,355 | May 17, 2012, 05:35 PM |
| BAKER JULIAN | Director | May 16, 2012 | Buy | $34.46 | 23,621 | 813,925 | 8,922,942 | May 16, 2012, 08:18 PM |
| BAKER JULIAN | Director | May 15, 2012 | Buy | $34.09 | 140,000 | 4,772,474 | 8,899,838 | May 16, 2012, 08:18 PM |
| BAKER JULIAN | Director | May 14, 2012 | Buy | $33.68 | 212,438 | 7,153,896 | 8,762,905 | May 16, 2012, 08:18 PM |
| Scott Randal W | CEO, InVitae Corporation* | May 11, 2012 | Sale | $30.52 | 15,000 | 457,742 | 1,252,917 | May 14, 2012, 05:39 PM |
| Scott Randal W | CEO, InVitae Corporation* | May 10, 2012 | Sale | $29.93 | 15,000 | 448,981 | 1,260,517 | May 14, 2012, 05:39 PM |
| BAKER JULIAN | Director | May 11, 2012 | Buy | $30.22 | 26,660 | 805,567 | 8,555,121 | May 11, 2012, 06:01 PM |
| BAKER JULIAN | Director | May 10, 2012 | Buy | $29.87 | 68,681 | 2,051,783 | 8,529,088 | May 11, 2012, 06:01 PM |
| BAKER JULIAN | Director | May 09, 2012 | Buy | $29.90 | 19,547 | 584,367 | 8,462,023 | May 11, 2012, 06:01 PM |
| Cole G Bradley | COO | May 09, 2012 | Option Exercise | $1.33 | 2,500 | 3,325 | 16,007 | May 11, 2012, 12:53 PM |
| Cole G Bradley | COO | May 09, 2012 | Sale | $28.87 | 2,500 | 72,174 | 13,507 | May 11, 2012, 12:53 PM |
| BAKER JULIAN | Director | May 07, 2012 | Buy | $28.26 | 56,540 | 1,597,965 | 8,358,928 | May 08, 2012, 07:00 PM |
| BAKER JULIAN | Director | May 04, 2012 | Buy | $28.02 | 53,128 | 1,488,643 | 8,305,414 | May 08, 2012, 07:00 PM |
| BAKER JULIAN | Director | May 08, 2012 | Buy | $28.83 | 86,033 | 2,480,619 | 8,442,936 | May 08, 2012, 07:00 PM |
| LIVINGSTON RANDALL S | Director | Apr 26, 2012 | Option Exercise | $1.33 | 2,000 | 2,653 | 8,149 | Apr 27, 2012, 04:30 PM |
| LIVINGSTON RANDALL S | Director | Apr 26, 2012 | Sale | $28.21 | 2,000 | 56,429 | 6,149 | Apr 27, 2012, 04:30 PM |
| Shak Steven | Chief Medical Officer | Apr 24, 2012 | Sale | $27.93 | 5,000 | 139,630 | 372,849 | Apr 26, 2012, 09:49 AM |
| Popovits Kimberly J | President and CEO | Apr 23, 2012 | Sale | $27.79 | 5,000 | 138,964 | 250,656 | Apr 24, 2012, 05:06 PM |
| Schorno Dean L | CFO | Apr 16, 2012 | Sale | $27.98 | 1,000 | 27,980 | 18,355 | Apr 17, 2012, 04:12 PM |
| Scott Randal W | CEO, InVitae Corporation* | Apr 11, 2012 | Sale | $28.38 | 10,000 | 283,790 | 1,275,117 | Apr 12, 2012, 05:36 PM |
| Scott Randal W | CEO, InVitae Corporation* | Apr 10, 2012 | Sale | $28.81 | 10,000 | 288,081 | 1,285,948 | Apr 12, 2012, 05:36 PM |
| Cole G Bradley | COO | Apr 04, 2012 | Option Exercise | $1.33 | 2,500 | 3,325 | 16,007 | Apr 06, 2012, 01:06 PM |
| Cole G Bradley | COO | Apr 04, 2012 | Sale | $30.28 | 2,500 | 75,691 | 13,507 | Apr 06, 2012, 01:06 PM |
| MYERS WOODROW A JR | Director | Apr 01, 2012 | Option Exercise | $30.61 | 326 | 9,979 | 1,937 | Apr 03, 2012, 02:17 PM |
| GRAHAM GINGER L | Director | Apr 01, 2012 | Option Exercise | $30.61 | 326 | 9,979 | 1,937 | Apr 03, 2012, 02:16 PM |
| COLELLA SAMUEL D | Director | Apr 01, 2012 | Option Exercise | $30.61 | 326 | 9,979 | 1,937 | Apr 03, 2012, 02:14 PM |
| Cohen Fred E | Director | Apr 01, 2012 | Option Exercise | $30.61 | 326 | 9,979 | 50,753 | Apr 03, 2012, 02:13 PM |
| Popovits Kimberly J | President and CEO | Mar 22, 2012 | Sale | $30.07 | 5,000 | 150,337 | 255,656 | Mar 26, 2012, 09:09 AM |
| Shak Steven | Chief Medical Officer | Mar 22, 2012 | Sale | $30.08 | 5,000 | 150,415 | 377,849 | Mar 26, 2012, 09:08 AM |
| Shak Steven | Chief Medical Officer | Mar 22, 2012 | Sale | $30.08 | 5,000 | 150,415 | 377,849 | Mar 23, 2012, 06:45 PM |
| Popovits Kimberly J | President and CEO | Mar 22, 2012 | Sale | $30.07 | 5,000 | 150,337 | 255,656 | Mar 23, 2012, 06:41 PM |
| Schorno Dean L | CFO | Mar 15, 2012 | Sale | $31.08 | 1,000 | 31,080 | 19,355 | Mar 19, 2012, 09:08 AM |
| Scott Randal W | CEO, InVitae Corporation | Mar 13, 2012 | Sale | $31.12 | 15,000 | 466,764 | 1,295,117 | Mar 14, 2012, 01:21 PM |
| Scott Randal W | CEO, InVitae Corporation | Mar 12, 2012 | Sale | $30.98 | 15,000 | 464,681 | 1,310,117 | Mar 14, 2012, 01:21 PM |
| Baker Biotech Capital (GP), LLC | Director | Mar 07, 2012 | Buy | $29.88 | 2,346 | 70,097 | 1,482,815 | Mar 09, 2012, 06:28 PM |
| Baker Biotech Capital (GP), LLC | Director | Mar 08, 2012 | Buy | $30.36 | 2,162 | 65,647 | 1,484,977 | Mar 09, 2012, 06:28 PM |
| 14159 capital (GP), LLC | Director | Mar 08, 2012 | Buy | $30.36 | 516 | 15,668 | 227,840 | Mar 09, 2012, 06:28 PM |
| 14159 capital (GP), LLC | Director | Mar 07, 2012 | Buy | $29.88 | 583 | 17,420 | 227,324 | Mar 09, 2012, 06:28 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Mar 08, 2012 | Buy | $30.36 | 19,513 | 592,489 | 8,255,421 | Mar 09, 2012, 06:27 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Mar 07, 2012 | Buy | $29.88 | 22,071 | 659,464 | 8,235,908 | Mar 09, 2012, 06:27 PM |
| Cole G Bradley | COO | Mar 08, 2012 | Option Exercise | $1.33 | 2,500 | 3,325 | 16,007 | Mar 09, 2012, 05:28 PM |
| Cole G Bradley | COO | Mar 08, 2012 | Sale | $29.94 | 2,500 | 74,850 | 13,507 | Mar 09, 2012, 05:28 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Mar 05, 2012 | Buy | $30.01 | 155,014 | 4,651,479 | 8,213,837 | Mar 05, 2012, 06:28 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Mar 02, 2012 | Buy | $29.52 | 91,459 | 2,699,915 | 8,058,823 | Mar 05, 2012, 06:28 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Mar 01, 2012 | Buy | $29.47 | 15,288 | 450,543 | 7,967,364 | Mar 05, 2012, 06:28 PM |
| 14159 capital (GP), LLC | Director | Mar 05, 2012 | Buy | $30.01 | 4,099 | 122,998 | 226,741 | Mar 05, 2012, 06:27 PM |
| 14159 capital (GP), LLC | Director | Mar 02, 2012 | Buy | $29.52 | 2,419 | 71,410 | 222,642 | Mar 05, 2012, 06:27 PM |
| 14159 capital (GP), LLC | Director | Mar 01, 2012 | Buy | $29.47 | 405 | 11,936 | 220,223 | Mar 05, 2012, 06:27 PM |
| Baker Biotech Capital (GP), LLC | Director | Mar 05, 2012 | Buy | $30.01 | 18,597 | 558,037 | 1,480,469 | Mar 05, 2012, 06:26 PM |
| Baker Biotech Capital (GP), LLC | Director | Mar 02, 2012 | Buy | $29.52 | 10,972 | 323,899 | 1,461,872 | Mar 05, 2012, 06:26 PM |
| Baker Biotech Capital (GP), LLC | Director | Mar 01, 2012 | Buy | $29.47 | 1,763 | 51,956 | 1,450,900 | Mar 05, 2012, 06:26 PM |
| 14159 capital (GP), LLC | Director | Feb 29, 2012 | Buy | $29.06 | 4,149 | 120,562 | 219,818 | Feb 29, 2012, 05:42 PM |
| 14159 capital (GP), LLC | Director | Feb 28, 2012 | Buy | $29.11 | 1,353 | 39,384 | 215,669 | Feb 29, 2012, 05:42 PM |
| 14159 capital (GP), LLC | Director | Feb 27, 2012 | Buy | $29.03 | 974 | 28,276 | 214,316 | Feb 29, 2012, 05:42 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Feb 28, 2012 | Buy | $29.11 | 51,248 | 1,491,752 | 7,795,174 | Feb 29, 2012, 05:41 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Feb 27, 2012 | Buy | $29.03 | 36,881 | 1,070,678 | 7,743,926 | Feb 29, 2012, 05:41 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Feb 29, 2012 | Buy | $29.06 | 156,902 | 4,559,274 | 7,952,076 | Feb 29, 2012, 05:41 PM |
| Baker Biotech Capital (GP), LLC | Director | Feb 29, 2012 | Buy | $29.06 | 19,552 | 568,144 | 1,449,137 | Feb 29, 2012, 05:39 PM |
| Baker Biotech Capital (GP), LLC | Director | Feb 28, 2012 | Buy | $29.11 | 5,934 | 172,730 | 1,429,585 | Feb 29, 2012, 05:39 PM |
| Baker Biotech Capital (GP), LLC | Director | Feb 27, 2012 | Buy | $29.03 | 4,270 | 123,961 | 1,423,651 | Feb 29, 2012, 05:39 PM |
| Popovits Kimberly J | President and CEO | Feb 23, 2012 | Sale | $28.15 | 5,000 | 140,740 | 265,656 | Feb 27, 2012, 04:34 PM |
| Popovits Kimberly J | President and CEO | Feb 24, 2012 | Sale | $28.85 | 5,000 | 144,255 | 260,656 | Feb 27, 2012, 04:34 PM |
| Shak Steven | Chief Medical Officer | Feb 23, 2012 | Sale | $28.14 | 5,000 | 140,723 | 382,849 | Feb 27, 2012, 04:33 PM |
| Schorno Dean L | CFO | Feb 15, 2012 | Option Exercise | $28.97 | 545 | 15,789 | 20,355 | Feb 24, 2012, 06:05 PM |
| Schorno Dean L | CFO | Feb 15, 2012 | Sale | $28.76 | 1,000 | 28,760 | 20,900 | Feb 24, 2012, 06:05 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Feb 22, 2012 | Buy | $27.98 | 5,511 | 154,204 | 7,644,947 | Feb 23, 2012, 06:11 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Feb 21, 2012 | Buy | $27.98 | 46,909 | 1,312,368 | 7,639,436 | Feb 23, 2012, 06:11 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Feb 23, 2012 | Buy | $28.12 | 62,098 | 1,746,432 | 7,707,045 | Feb 23, 2012, 06:11 PM |
| 14159 capital (GP), LLC | Director | Feb 23, 2012 | Buy | $28.12 | 1,639 | 46,095 | 213,342 | Feb 23, 2012, 06:08 PM |
| 14159 capital (GP), LLC | Director | Feb 22, 2012 | Buy | $27.98 | 145 | 4,057 | 211,703 | Feb 23, 2012, 06:08 PM |
| 14159 capital (GP), LLC | Director | Feb 21, 2012 | Buy | $27.98 | 1,238 | 34,635 | 211,558 | Feb 23, 2012, 06:08 PM |
| Baker Biotech Capital (GP), LLC | Director | Feb 23, 2012 | Buy | $28.12 | 7,477 | 210,282 | 1,419,381 | Feb 23, 2012, 06:08 PM |
| Baker Biotech Capital (GP), LLC | Director | Feb 22, 2012 | Buy | $27.98 | 638 | 17,852 | 1,411,904 | Feb 23, 2012, 06:08 PM |
| Baker Biotech Capital (GP), LLC | Director | Feb 21, 2012 | Buy | $27.98 | 5,217 | 145,955 | 1,411,266 | Feb 23, 2012, 06:08 PM |
| Shak Steven | Chief Medical Officer | Feb 15, 2012 | Option Exercise | $28.97 | 629 | 18,222 | 387,849 | Feb 17, 2012, 08:08 PM |
| Scott Randal W | Executive Chairman | Feb 15, 2012 | Option Exercise | $28.97 | 629 | 18,222 | 1,325,117 | Feb 17, 2012, 08:05 PM |
| Schorno Dean L | CFO | Feb 15, 2012 | Option Exercise | $28.97 | 545 | 15,789 | 20,600 | Feb 17, 2012, 08:01 PM |
| Schorno Dean L | CFO | Feb 15, 2012 | Sale | $28.76 | 755 | 21,714 | 21,145 | Feb 17, 2012, 08:01 PM |
| Popovits Kimberly J | President and CEO | Feb 15, 2012 | Option Exercise | $28.97 | 1,396 | 40,442 | 18,604 | Feb 17, 2012, 07:56 PM |
| Cole G Bradley | COO | Feb 15, 2012 | Option Exercise | $28.97 | 943 | 27,319 | 13,507 | Feb 17, 2012, 07:41 PM |
| Baker Joffre | Chief Scientific Officer | Feb 15, 2012 | Option Exercise | $28.97 | 629 | 18,222 | 132,846 | Feb 17, 2012, 07:37 PM |
| Baker Biotech Capital (GP), LLC | Director | Feb 16, 2012 | Buy | $29.73 | 21,900 | 651,092 | 1,406,049 | Feb 16, 2012, 06:58 PM |
| Baker Biotech Capital (GP), LLC | Director | Feb 15, 2012 | Buy | $28.88 | 3,944 | 113,892 | 1,384,149 | Feb 16, 2012, 06:58 PM |
| Baker Biotech Capital (GP), LLC | Director | Feb 14, 2012 | Buy | $28.44 | 7,341 | 208,756 | 1,380,205 | Feb 16, 2012, 06:58 PM |
| 14159 capital (GP), LLC | Director | Feb 15, 2012 | Buy | $28.88 | 849 | 24,517 | 205,431 | Feb 16, 2012, 06:58 PM |
| 14159 capital (GP), LLC | Director | Feb 14, 2012 | Buy | $28.44 | 1,475 | 41,945 | 204,582 | Feb 16, 2012, 06:58 PM |
| 14159 capital (GP), LLC | Director | Feb 16, 2012 | Buy | $29.73 | 4,889 | 145,350 | 210,320 | Feb 16, 2012, 06:58 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Feb 16, 2012 | Buy | $29.73 | 184,980 | 5,499,497 | 7,592,527 | Feb 16, 2012, 06:57 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Feb 15, 2012 | Buy | $28.88 | 32,125 | 927,680 | 7,407,547 | Feb 16, 2012, 06:57 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Feb 14, 2012 | Buy | $28.44 | 55,804 | 1,586,898 | 7,375,422 | Feb 16, 2012, 06:57 PM |
| Scott Randal W | Executive Chairman | Feb 10, 2012 | Sale | $26.25 | 10,000 | 262,495 | 1,325,746 | Feb 14, 2012, 07:04 PM |
| Scott Randal W | Executive Chairman | Feb 09, 2012 | Sale | $26.10 | 10,000 | 261,029 | 1,335,746 | Feb 14, 2012, 07:04 PM |
| Scott Randal W | Executive Chairman | Feb 10, 2012 | Sale | $26.25 | 10,000 | 262,495 | 1,325,746 | Feb 13, 2012, 09:25 AM |
| Scott Randal W | Executive Chairman | Feb 09, 2012 | Sale | $26.10 | 10,000 | 261,029 | 1,335,746 | Feb 13, 2012, 09:25 AM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Feb 10, 2012 | Buy | $26.59 | 159,832 | 4,249,931 | 7,319,618 | Feb 10, 2012, 09:34 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Feb 09, 2012 | Buy | $26.32 | 55,994 | 1,473,628 | 7,159,786 | Feb 10, 2012, 09:34 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Feb 08, 2012 | Buy | $26.20 | 202,089 | 5,294,563 | 7,103,792 | Feb 10, 2012, 09:34 PM |
| 14159 capital (GP), LLC | Director | Feb 10, 2012 | Buy | $26.59 | 4,225 | 112,343 | 203,107 | Feb 10, 2012, 09:33 PM |
| 14159 capital (GP), LLC | Director | Feb 09, 2012 | Buy | $26.32 | 1,478 | 38,898 | 198,882 | Feb 10, 2012, 09:33 PM |
| 14159 capital (GP), LLC | Director | Feb 08, 2012 | Buy | $26.20 | 5,340 | 139,904 | 197,404 | Feb 10, 2012, 09:33 PM |
| Baker Biotech Capital (GP), LLC | Director | Feb 10, 2012 | Buy | $26.59 | 24,582 | 653,635 | 1,372,864 | Feb 10, 2012, 09:33 PM |
| Baker Biotech Capital (GP), LLC | Director | Feb 09, 2012 | Buy | $26.32 | 8,860 | 233,174 | 1,348,282 | Feb 10, 2012, 09:33 PM |
| Baker Biotech Capital (GP), LLC | Director | Feb 08, 2012 | Buy | $26.20 | 33,141 | 868,267 | 1,339,422 | Feb 10, 2012, 09:33 PM |
| Cole G Bradley | COO | Feb 08, 2012 | Option Exercise | $1.33 | 2,500 | 3,325 | 16,950 | Feb 09, 2012, 09:16 AM |
| Cole G Bradley | COO | Feb 08, 2012 | Sale | $26.47 | 2,500 | 66,172 | 14,450 | Feb 09, 2012, 09:16 AM |
| LIVINGSTON RANDALL S | Director | Jan 26, 2012 | Option Exercise | $1.33 | 2,000 | 2,653 | 8,149 | Jan 27, 2012, 01:53 PM |
| LIVINGSTON RANDALL S | Director | Jan 26, 2012 | Sale | $27.51 | 2,000 | 55,020 | 6,149 | Jan 27, 2012, 01:53 PM |
| Popovits Kimberly J | President and CEO | Jan 25, 2012 | Sale | $26.42 | 5,000 | 132,085 | 273,292 | Jan 26, 2012, 09:19 AM |
| Popovits Kimberly J | President and CEO | Jan 24, 2012 | Sale | $26.62 | 5,000 | 133,078 | 278,292 | Jan 25, 2012, 05:27 PM |
| Shak Steven | Chief Medical Officer | Jan 24, 2012 | Sale | $26.74 | 5,000 | 133,678 | 382,778 | Jan 25, 2012, 05:24 PM |
| Schorno Dean L | CFO | Jan 17, 2012 | Sale | $28.00 | 1,000 | 27,999 | 17,900 | Jan 18, 2012, 11:44 AM |
| Cole G Bradley | COO | Jan 12, 2012 | Option Exercise | $1.33 | 2,500 | 3,325 | 10,250 | Jan 18, 2012, 11:43 AM |
| Cole G Bradley | COO | Jan 12, 2012 | Sale | $27.54 | 2,500 | 68,844 | 7,750 | Jan 18, 2012, 11:43 AM |
| Scott Randal W | Executive Chairman | Jan 11, 2012 | Sale | $27.56 | 10,000 | 275,612 | 1,341,246 | Jan 12, 2012, 01:47 PM |
| Scott Randal W | Executive Chairman | Jan 10, 2012 | Sale | $27.35 | 10,000 | 273,530 | 1,351,146 | Jan 12, 2012, 01:47 PM |
| Cohen Fred E | Director | Jan 01, 2012 | Option Exercise | $25.39 | 393 | 9,978 | 50,427 | Jan 06, 2012, 06:33 PM |
| GRAHAM GINGER L | Director | Jan 01, 2012 | Option Exercise | $25.39 | 393 | 9,978 | 1,611 | Jan 06, 2012, 06:32 PM |
| MYERS WOODROW A JR | Director | Jan 01, 2012 | Option Exercise | $25.39 | 393 | 9,978 | 1,611 | Jan 06, 2012, 06:31 PM |
| COLELLA SAMUEL D | Director | Jan 01, 2012 | Option Exercise | $25.39 | 393 | 9,978 | 1,611 | Jan 06, 2012, 06:30 PM |
| Shak Steven | Chief Medical Officer | Dec 22, 2011 | Sale | $26.03 | 5,000 | 130,156 | 387,778 | Dec 23, 2011, 10:26 AM |
| Scott Randal W | Executive Chairman | Dec 13, 2011 | Sale | $27.01 | 10,000 | 270,078 | 1,363,256 | Dec 14, 2011, 03:35 PM |
| Scott Randal W | Executive Chairman | Dec 12, 2011 | Sale | $27.57 | 10,000 | 275,652 | 1,371,246 | Dec 14, 2011, 03:35 PM |
| Cole G Bradley | COO | Dec 06, 2011 | Option Exercise | $1.33 | 2,500 | 3,325 | 10,250 | Dec 08, 2011, 12:00 PM |
| Cole G Bradley | COO | Dec 06, 2011 | Sale | $28.59 | 2,500 | 71,464 | 7,750 | Dec 08, 2011, 12:00 PM |
| 14159 capital (GP), LLC | Director | Dec 02, 2011 | Buy | $28.05 | 2,604 | 73,045 | 191,516 | Dec 05, 2011, 06:19 PM |
| 14159 capital (GP), LLC | Director | Dec 05, 2011 | Buy | $28.45 | 548 | 15,593 | 192,064 | Dec 05, 2011, 06:19 PM |
| Baker Biotech Capital (GP), LLC | Director | Dec 05, 2011 | Buy | $28.45 | 3,377 | 96,092 | 1,306,281 | Dec 05, 2011, 06:18 PM |
| Baker Biotech Capital (GP), LLC | Director | Dec 02, 2011 | Buy | $28.05 | 16,063 | 450,585 | 1,302,904 | Dec 05, 2011, 06:18 PM |
| Baker Biotech Capital (GP), LLC | Director | Dec 01, 2011 | Buy | $27.33 | 26,537 | 725,256 | 1,286,841 | Dec 05, 2011, 06:18 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Dec 05, 2011 | Buy | $28.45 | 20,456 | 582,072 | 6,901,703 | Dec 05, 2011, 06:16 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Dec 02, 2011 | Buy | $28.05 | 97,295 | 2,729,234 | 6,881,247 | Dec 05, 2011, 06:16 PM |
| 14159 capital (GP), LLC | Director | Nov 23, 2011 | Buy | $25.83 | 539 | 13,923 | 188,912 | Nov 23, 2011, 05:00 PM |
| 14159 capital (GP), LLC | Director | Nov 22, 2011 | Buy | $26.03 | 2,044 | 53,206 | 188,373 | Nov 23, 2011, 05:00 PM |
| 14159 capital (GP), LLC | Director | Nov 21, 2011 | Buy | $25.91 | 3,167 | 82,041 | 186,329 | Nov 23, 2011, 05:00 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Nov 23, 2011 | Buy | $25.83 | 67,427 | 1,741,720 | 6,783,952 | Nov 23, 2011, 04:59 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Nov 22, 2011 | Buy | $26.03 | 46,328 | 1,205,927 | 6,716,525 | Nov 23, 2011, 04:59 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Nov 21, 2011 | Buy | $25.91 | 79,984 | 2,071,986 | 6,670,197 | Nov 23, 2011, 04:59 PM |
| Baker Biotech Capital (GP), LLC | Director | Nov 22, 2011 | Buy | $26.03 | 1,628 | 42,377 | 1,258,031 | Nov 23, 2011, 04:59 PM |
| Baker Biotech Capital (GP), LLC | Director | Nov 21, 2011 | Buy | $25.91 | 1,630 | 42,225 | 1,256,403 | Nov 23, 2011, 04:59 PM |
| Baker Biotech Capital (GP), LLC | Director | Nov 23, 2011 | Buy | $25.83 | 2,273 | 58,714 | 1,260,304 | Nov 23, 2011, 04:59 PM |
| Shak Steven | Chief Medical Officer | Nov 22, 2011 | Option Exercise | $9.39 | 5,000 | 46,950 | 397,778 | Nov 23, 2011, 11:43 AM |
| Shak Steven | Chief Medical Officer | Nov 22, 2011 | Sale | $26.07 | 5,000 | 130,328 | 392,778 | Nov 23, 2011, 11:43 AM |
| Scott Randal W | Executive Chairman | Oct 11, 2011 | Sale | $22.60 | 10,000 | 225,985 | 1,431,146 | Nov 22, 2011, 07:05 PM |
| Scott Randal W | Executive Chairman | Oct 10, 2011 | Sale | $23.06 | 10,000 | 230,608 | 1,441,146 | Nov 22, 2011, 07:05 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Nov 16, 2011 | Buy | $27.35 | 24,256 | 663,310 | 6,590,213 | Nov 17, 2011, 05:35 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Nov 15, 2011 | Buy | $27.93 | 40,341 | 1,126,870 | 6,565,957 | Nov 17, 2011, 05:35 PM |
| 14159 capital (GP), LLC | Director | Nov 16, 2011 | Buy | $27.35 | 951 | 26,006 | 183,162 | Nov 17, 2011, 05:35 PM |
| 14159 capital (GP), LLC | Director | Nov 15, 2011 | Buy | $27.93 | 1,599 | 44,666 | 182,211 | Nov 17, 2011, 05:35 PM |
| Baker Biotech Capital (GP), LLC | Director | Nov 16, 2011 | Buy | $27.35 | 458 | 12,525 | 1,254,773 | Nov 17, 2011, 05:34 PM |
| 14159 capital (GP), LLC | Director | Nov 14, 2011 | Buy | $27.25 | 1,567 | 42,707 | 180,612 | Nov 14, 2011, 06:13 PM |
| 14159 capital (GP), LLC | Director | Nov 11, 2011 | Buy | $27.66 | 4,052 | 112,088 | 179,045 | Nov 14, 2011, 06:13 PM |
| 14159 capital (GP), LLC | Director | Nov 10, 2011 | Buy | $26.89 | 1,509 | 40,573 | 174,993 | Nov 14, 2011, 06:13 PM |
| 14159 capital (GP), LLC | Director | Nov 09, 2011 | Buy | $26.79 | 2,978 | 79,778 | 173,484 | Nov 14, 2011, 06:13 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Nov 14, 2011 | Buy | $27.25 | 39,117 | 1,066,091 | 6,525,616 | Nov 14, 2011, 06:13 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Nov 11, 2011 | Buy | $27.66 | 100,823 | 2,789,006 | 6,486,499 | Nov 14, 2011, 06:13 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Nov 10, 2011 | Buy | $26.89 | 36,956 | 993,654 | 6,385,676 | Nov 14, 2011, 06:13 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Nov 09, 2011 | Buy | $26.79 | 72,479 | 1,941,654 | 6,348,720 | Nov 14, 2011, 06:13 PM |
| Baker Biotech Capital (GP), LLC | Director | Nov 09, 2011 | Buy | $26.79 | 542 | 14,520 | 1,254,315 | Nov 14, 2011, 05:17 PM |
| Scott Randal W | Executive Chairman | Nov 10, 2011 | Sale | $26.95 | 10,000 | 269,549 | 1,421,146 | Nov 14, 2011, 01:28 PM |
| Scott Randal W | Executive Chairman | Nov 11, 2011 | Sale | $27.53 | 10,000 | 275,280 | 1,411,146 | Nov 14, 2011, 01:28 PM |
| Cole G Bradley | COO | Nov 08, 2011 | Option Exercise | $1.33 | 2,500 | 3,325 | 10,250 | Nov 09, 2011, 03:47 PM |
| Cole G Bradley | COO | Nov 08, 2011 | Sale | $26.60 | 2,500 | 66,506 | 7,750 | Nov 09, 2011, 03:47 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Nov 07, 2011 | Buy | $26.24 | 132,371 | 3,474,033 | 6,276,241 | Nov 07, 2011, 06:10 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Nov 04, 2011 | Buy | $25.78 | 55,920 | 1,441,461 | 6,143,870 | Nov 07, 2011, 06:10 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Nov 03, 2011 | Buy | $24.48 | 21,221 | 519,553 | 6,087,950 | Nov 07, 2011, 06:10 PM |
| 14159 capital (GP), LLC | Director | Nov 07, 2011 | Buy | $26.24 | 5,584 | 146,550 | 170,506 | Nov 07, 2011, 06:10 PM |
| 14159 capital (GP), LLC | Director | Nov 04, 2011 | Buy | $25.78 | 2,365 | 60,963 | 164,922 | Nov 07, 2011, 06:10 PM |
| 14159 capital (GP), LLC | Director | Nov 03, 2011 | Buy | $24.48 | 898 | 21,986 | 162,557 | Nov 07, 2011, 06:10 PM |
| Baker Biotech Capital (GP), LLC | Director | Nov 03, 2011 | Buy | $24.48 | 120 | 2,938 | 1,253,773 | Nov 07, 2011, 06:08 PM |
| LIVINGSTON RANDALL S | Director | Oct 27, 2011 | Option Exercise | $1.33 | 2,000 | 2,653 | 8,149 | Oct 31, 2011, 04:14 PM |
| LIVINGSTON RANDALL S | Director | Oct 27, 2011 | Sale | $22.08 | 2,000 | 44,160 | 6,149 | Oct 31, 2011, 04:14 PM |
| Shak Steven | Chief Medical Officer | Oct 24, 2011 | Option Exercise | $9.39 | 5,000 | 46,950 | 397,778 | Oct 26, 2011, 03:39 PM |
| Shak Steven | Chief Medical Officer | Oct 24, 2011 | Sale | $21.76 | 5,000 | 108,821 | 392,778 | Oct 26, 2011, 03:39 PM |
| Cole G Bradley | COO | Oct 06, 2011 | Option Exercise | $1.33 | 5,000 | 6,650 | 12,750 | Oct 07, 2011, 03:41 PM |
| Cole G Bradley | COO | Oct 06, 2011 | Sale | $22.31 | 5,000 | 111,546 | 7,750 | Oct 07, 2011, 03:41 PM |
| MYERS WOODROW A JR | Director | Oct 01, 2011 | Option Exercise | $21.98 | 454 | 9,979 | 1,218 | Oct 04, 2011, 06:44 PM |
| GRAHAM GINGER L | Director | Oct 01, 2011 | Option Exercise | $21.98 | 454 | 9,979 | 1,218 | Oct 04, 2011, 06:43 PM |
| COLELLA SAMUEL D | Director | Oct 01, 2011 | Option Exercise | $21.98 | 454 | 9,979 | 1,218 | Oct 04, 2011, 06:42 PM |
| Cohen Fred E | Director | Oct 01, 2011 | Option Exercise | $21.98 | 454 | 9,979 | 49,903 | Oct 04, 2011, 06:41 PM |
| Shak Steven | Chief Medical Officer | Sep 27, 2011 | Option Exercise | $9.39 | 5,000 | 46,950 | 397,778 | Sep 29, 2011, 09:40 AM |
| Shak Steven | Chief Medical Officer | Sep 27, 2011 | Sale | $19.65 | 5,000 | 98,230 | 392,778 | Sep 29, 2011, 09:40 AM |
| Scott Randal W | Executive Chairman | Sep 12, 2011 | Sale | $20.72 | 10,000 | 207,237 | 1,461,146 | Sep 14, 2011, 12:54 PM |
| Scott Randal W | Executive Chairman | Sep 13, 2011 | Sale | $20.90 | 10,000 | 209,032 | 1,451,146 | Sep 14, 2011, 12:54 PM |
| Cole G Bradley | COO | Sep 06, 2011 | Option Exercise | $1.33 | 2,500 | 3,325 | 10,250 | Sep 08, 2011, 09:48 AM |
| Cole G Bradley | COO | Sep 06, 2011 | Sale | $22.08 | 2,500 | 55,209 | 7,750 | Sep 08, 2011, 09:48 AM |
| Cole G Bradley | COO | Aug 08, 2011 | Option Exercise | $1.33 | 2,500 | 3,325 | 10,250 | Sep 07, 2011, 05:22 PM |
| Cole G Bradley | COO | Aug 08, 2011 | Sale | $25.26 | 2,500 | 63,142 | 7,750 | Sep 07, 2011, 05:22 PM |
| Shak Steven | Chief Medical Officer | Aug 24, 2011 | Option Exercise | $9.39 | 5,000 | 46,950 | 397,778 | Aug 26, 2011, 09:20 AM |
| Shak Steven | Chief Medical Officer | Aug 24, 2011 | Sale | $23.02 | 5,000 | 115,108 | 392,778 | Aug 26, 2011, 09:20 AM |
| Scott Randal W | Executive Chairman | Aug 11, 2011 | Sale | $24.40 | 10,000 | 243,979 | 1,471,146 | Aug 12, 2011, 08:05 PM |
| Scott Randal W | Executive Chairman | Aug 10, 2011 | Sale | $24.48 | 10,000 | 244,751 | 1,481,146 | Aug 12, 2011, 08:05 PM |
| Cole G Bradley | COO | Aug 08, 2011 | Option Exercise | $1.33 | 2,500 | 3,325 | 10,250 | Aug 10, 2011, 08:11 PM |
| Cole G Bradley | COO | Aug 08, 2011 | Sale | $25.26 | 2,500 | 63,142 | 7,750 | Aug 10, 2011, 08:11 PM |
| LIVINGSTON RANDALL S | Director | Jul 27, 2011 | Option Exercise | $1.33 | 2,000 | 2,653 | 8,149 | Jul 29, 2011, 09:42 AM |
| LIVINGSTON RANDALL S | Director | Jul 27, 2011 | Sale | $26.45 | 2,000 | 52,907 | 6,149 | Jul 29, 2011, 09:42 AM |
| Shak Steven | Chief Medical Officer | Jul 25, 2011 | Option Exercise | $9.39 | 5,000 | 46,950 | 397,778 | Jul 27, 2011, 10:02 AM |
| Shak Steven | Chief Medical Officer | Jul 25, 2011 | Sale | $27.61 | 5,000 | 138,053 | 392,778 | Jul 27, 2011, 10:02 AM |
| Scott Randal W | Executive Chairman | Jul 12, 2011 | Sale | $27.17 | 10,000 | 271,653 | 1,491,146 | Jul 13, 2011, 02:23 PM |
| Scott Randal W | Executive Chairman | Jul 11, 2011 | Sale | $27.56 | 10,000 | 275,558 | 1,501,146 | Jul 13, 2011, 02:23 PM |
| Cole G Bradley | COO | Jul 06, 2011 | Option Exercise | $1.33 | 5,000 | 6,650 | 12,750 | Jul 08, 2011, 09:33 AM |
| Cole G Bradley | COO | Jul 06, 2011 | Sale | $27.74 | 5,000 | 138,686 | 7,750 | Jul 08, 2011, 09:33 AM |
| MYERS WOODROW A JR | Director | Jul 01, 2011 | Option Exercise | $27.91 | 358 | 9,992 | 764 | Jul 06, 2011, 10:14 AM |
| GRAHAM GINGER L | Director | Jul 01, 2011 | Option Exercise | $27.91 | 358 | 9,992 | 764 | Jul 06, 2011, 10:13 AM |
| COLELLA SAMUEL D | Director | Jul 01, 2011 | Option Exercise | $27.91 | 358 | 9,992 | 764 | Jul 06, 2011, 10:12 AM |
| Cohen Fred E | Director | Jul 01, 2011 | Option Exercise | $27.91 | 358 | 9,992 | 49,449 | Jul 06, 2011, 10:10 AM |
| Shak Steven | Chief Medical Officer | Jun 23, 2011 | Option Exercise | $9.39 | 5,000 | 46,950 | 397,778 | Jun 27, 2011, 02:01 PM |
| Shak Steven | Chief Medical Officer | Jun 23, 2011 | Sale | $27.12 | 5,000 | 135,581 | 392,778 | Jun 27, 2011, 02:01 PM |
| Schorno Dean L | CFO | Jun 15, 2011 | Sale | $25.91 | 1,000 | 25,909 | 18,900 | Jun 16, 2011, 06:02 PM |
| Scott Randal W | Executive Chairman | Jun 13, 2011 | Sale | $25.37 | 10,000 | 253,698 | 1,511,146 | Jun 14, 2011, 06:19 PM |
| Scott Randal W | Executive Chairman | Jun 10, 2011 | Sale | $26.01 | 10,000 | 260,140 | 1,521,146 | Jun 14, 2011, 06:19 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Jun 09, 2011 | Buy | $26.26 | 89,891 | 2,360,109 | 6,059,449 | Jun 09, 2011, 05:34 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Jun 08, 2011 | Buy | $26.13 | 44,563 | 1,164,432 | 5,969,558 | Jun 09, 2011, 05:34 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Jun 07, 2011 | Buy | $26.16 | 69,198 | 1,810,136 | 5,924,995 | Jun 09, 2011, 05:34 PM |
| 14159 capital (GP), LLC | Director | Jun 08, 2011 | Buy | $26.13 | 1,065 | 27,828 | 159,988 | Jun 09, 2011, 05:33 PM |
| 14159 capital (GP), LLC | Director | Jun 07, 2011 | Buy | $26.16 | 1,652 | 43,214 | 158,923 | Jun 09, 2011, 05:33 PM |
| 14159 capital (GP), LLC | Director | Jun 09, 2011 | Buy | $26.26 | 1,671 | 43,873 | 161,659 | Jun 09, 2011, 05:33 PM |
| Baker Bros. Capital (GP), LLC | Director | Jun 09, 2011 | Buy | $26.25 | 49 | 1,286 | 194,415 | Jun 09, 2011, 05:32 PM |
| Baker Bros. Capital (GP), LLC | Director | Jun 08, 2011 | Buy | $26.13 | 27 | 706 | 194,366 | Jun 09, 2011, 05:32 PM |
| Baker Bros. Capital (GP), LLC | Director | Jun 07, 2011 | Buy | $26.16 | 43 | 1,125 | 194,339 | Jun 09, 2011, 05:32 PM |
| Cole G Bradley | COO | Jun 06, 2011 | Option Exercise | $1.33 | 2,500 | 3,325 | 10,250 | Jun 08, 2011, 05:14 PM |
| Cole G Bradley | COO | Jun 06, 2011 | Sale | $26.18 | 2,500 | 65,452 | 7,750 | Jun 08, 2011, 05:14 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Jun 01, 2011 | Buy | $27.49 | 71,471 | 1,964,575 | 5,855,797 | Jun 01, 2011, 06:15 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | May 31, 2011 | Buy | $27.48 | 55,039 | 1,512,235 | 5,784,326 | Jun 01, 2011, 06:15 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | May 27, 2011 | Buy | $27.04 | 55,183 | 1,491,922 | 5,729,287 | Jun 01, 2011, 06:15 PM |
| 14159 capital (GP), LLC | Director | Jun 01, 2011 | Buy | $27.49 | 1,706 | 46,894 | 157,271 | Jun 01, 2011, 05:31 PM |
| 14159 capital (GP), LLC | Director | May 31, 2011 | Buy | $27.48 | 1,461 | 40,142 | 155,565 | Jun 01, 2011, 05:31 PM |
| 14159 capital (GP), LLC | Director | May 27, 2011 | Buy | $27.04 | 1,464 | 39,581 | 154,104 | Jun 01, 2011, 05:31 PM |
| Baker Bros. Capital (GP), LLC | Director | Jun 01, 2011 | Buy | $27.49 | 44 | 1,209 | 194,296 | Jun 01, 2011, 05:23 PM |
| Baker Bros. Capital (GP), LLC | Director | May 31, 2011 | Buy | $27.48 | 34 | 934 | 194,252 | Jun 01, 2011, 05:23 PM |
| Baker Bros. Capital (GP), LLC | Director | May 27, 2011 | Buy | $27.04 | 34 | 919 | 194,218 | Jun 01, 2011, 05:23 PM |
| Shak Steven | Chief Medical Officer | May 25, 2011 | Option Exercise | $9.39 | 5,000 | 46,950 | 397,778 | May 26, 2011, 08:03 PM |
| Shak Steven | Chief Medical Officer | May 25, 2011 | Sale | $25.55 | 5,000 | 127,773 | 392,778 | May 26, 2011, 08:03 PM |
| Schorno Dean L | CFO | May 12, 2011 | Sale | $26.48 | 1,000 | 26,479 | 19,900 | May 16, 2011, 07:29 PM |
| Scott Randal W | Executive Chairman | May 10, 2011 | Sale | $26.59 | 10,000 | 265,911 | 1,541,146 | May 11, 2011, 08:33 PM |
| Scott Randal W | Executive Chairman | May 11, 2011 | Sale | $26.72 | 10,000 | 267,202 | 1,531,146 | May 11, 2011, 08:33 PM |
| Cole G Bradley | COO | May 09, 2011 | Option Exercise | $1.33 | 2,500 | 3,325 | 10,250 | May 11, 2011, 08:29 PM |
| Cole G Bradley | COO | May 09, 2011 | Sale | $25.93 | 2,500 | 64,833 | 7,750 | May 11, 2011, 08:29 PM |
| LIVINGSTON RANDALL S | Director | Apr 27, 2011 | Option Exercise | $1.33 | 2,000 | 2,653 | 8,149 | Apr 29, 2011, 07:25 PM |
| LIVINGSTON RANDALL S | Director | Apr 27, 2011 | Sale | $26.04 | 2,000 | 52,073 | 6,149 | Apr 29, 2011, 07:25 PM |
| Shak Steven | Chief Medical Officer | Apr 25, 2011 | Option Exercise | $9.39 | 5,000 | 46,950 | 397,778 | Apr 27, 2011, 08:32 PM |
| Shak Steven | Chief Medical Officer | Apr 25, 2011 | Sale | $25.38 | 5,000 | 126,908 | 392,778 | Apr 27, 2011, 08:32 PM |
| Schorno Dean L | CFO | Apr 14, 2011 | Sale | $25.32 | 1,000 | 25,319 | 20,900 | Apr 18, 2011, 09:50 PM |
| Popovits Kimberly J | President and CEO | Apr 15, 2011 | Option Exercise | $9.39 | 4,000 | 37,560 | 14,000 | Apr 18, 2011, 09:41 PM |
| Popovits Kimberly J | President and CEO | Apr 14, 2011 | Option Exercise | $9.39 | 4,000 | 37,560 | 14,000 | Apr 18, 2011, 09:41 PM |
| Popovits Kimberly J | President and CEO | Apr 15, 2011 | Sale | $25.64 | 4,000 | 102,573 | 10,000 | Apr 18, 2011, 09:41 PM |
| Popovits Kimberly J | President and CEO | Apr 14, 2011 | Sale | $25.33 | 4,000 | 101,317 | 10,000 | Apr 18, 2011, 09:41 PM |
| Popovits Kimberly J | President and CEO | Mar 15, 2011 | Option Exercise | $9.39 | 4,000 | 37,560 | 14,000 | Apr 18, 2011, 09:30 PM |
| Popovits Kimberly J | President and CEO | Mar 14, 2011 | Option Exercise | $9.39 | 4,000 | 37,560 | 14,000 | Apr 18, 2011, 09:30 PM |
| Popovits Kimberly J | President and CEO | Mar 14, 2011 | Sale | $24.77 | 4,000 | 99,098 | 10,000 | Apr 18, 2011, 09:30 PM |
| Popovits Kimberly J | President and CEO | Mar 15, 2011 | Sale | $23.81 | 4,000 | 95,256 | 10,000 | Apr 18, 2011, 09:30 PM |
| Scott Randal W | Executive Chairman | Apr 12, 2011 | Sale | $25.92 | 10,000 | 259,185 | 1,561,146 | Apr 13, 2011, 09:49 PM |
| Scott Randal W | Executive Chairman | Apr 11, 2011 | Sale | $26.01 | 10,000 | 260,053 | 1,571,146 | Apr 13, 2011, 09:49 PM |
| Cole G Bradley | COO | Apr 06, 2011 | Option Exercise | $1.33 | 5,000 | 6,650 | 12,750 | Apr 07, 2011, 04:31 PM |
| Cole G Bradley | COO | Apr 06, 2011 | Sale | $26.91 | 5,000 | 134,572 | 7,750 | Apr 07, 2011, 04:31 PM |
| MYERS WOODROW A JR | Director | Apr 01, 2011 | Option Exercise | $24.60 | 406 | 9,988 | 406 | Apr 05, 2011, 06:18 PM |
| GRAHAM GINGER L | Director | Apr 01, 2011 | Option Exercise | $24.60 | 406 | 9,988 | 406 | Apr 05, 2011, 06:16 PM |
| COLELLA SAMUEL D | Director | Apr 01, 2011 | Option Exercise | $24.60 | 406 | 9,988 | 406 | Apr 05, 2011, 06:10 PM |
| Cohen Fred E | Director | Apr 01, 2011 | Option Exercise | $24.60 | 406 | 9,988 | 49,091 | Apr 05, 2011, 06:07 PM |
| BYERS BROOK H | Director | Apr 04, 2011 | Option Exercise | $24.60 | 406 | 9,988 | 406 | Apr 05, 2011, 06:04 PM |
| Shak Steven | Chief Medical Officer | Mar 24, 2011 | Option Exercise | $9.39 | 5,000 | 46,950 | 397,778 | Mar 28, 2011, 08:23 PM |
| Shak Steven | Chief Medical Officer | Mar 24, 2011 | Sale | $24.45 | 5,000 | 122,254 | 392,778 | Mar 28, 2011, 08:23 PM |
| Schorno Dean L | CFO | Mar 15, 2011 | Sale | $23.79 | 1,000 | 23,787 | 21,900 | Mar 16, 2011, 05:51 PM |
| Popovits Kimberly J | President and CEO | Mar 15, 2011 | Option Exercise | $9.39 | 4,000 | 37,560 | 300,916 | Mar 16, 2011, 05:48 PM |
| Popovits Kimberly J | President and CEO | Mar 14, 2011 | Option Exercise | $9.39 | 4,000 | 37,560 | 300,916 | Mar 16, 2011, 05:48 PM |
| Popovits Kimberly J | President and CEO | Mar 15, 2011 | Sale | $23.81 | 4,000 | 95,256 | 296,916 | Mar 16, 2011, 05:48 PM |
| Popovits Kimberly J | President and CEO | Mar 14, 2011 | Sale | $24.77 | 4,000 | 99,098 | 296,916 | Mar 16, 2011, 05:48 PM |
| Scott Randal W | Executive Chairman | Mar 11, 2011 | Sale | $25.64 | 10,000 | 256,372 | 1,581,146 | Mar 14, 2011, 02:57 PM |
| Scott Randal W | Executive Chairman | Mar 10, 2011 | Sale | $25.61 | 10,000 | 256,123 | 1,591,146 | Mar 14, 2011, 02:57 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Mar 10, 2011 | Buy | $25.56 | 20,000 | 511,150 | 5,674,104 | Mar 11, 2011, 04:33 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Mar 09, 2011 | Buy | $26.22 | 50,856 | 1,333,262 | 5,654,104 | Mar 11, 2011, 04:33 PM |
| Cole G Bradley | COO | Mar 08, 2011 | Option Exercise | $1.33 | 2,500 | 3,325 | 10,250 | Mar 10, 2011, 08:30 PM |
| Cole G Bradley | COO | Mar 08, 2011 | Sale | $25.23 | 2,500 | 63,071 | 7,750 | Mar 10, 2011, 08:30 PM |
| 14159 capital (GP), LLC | Director | Mar 08, 2011 | Buy | $25.13 | 50 | 1,256 | 152,640 | Mar 08, 2011, 05:37 PM |
| 14159 capital (GP), LLC | Director | Mar 07, 2011 | Buy | $24.99 | 8,207 | 205,095 | 152,590 | Mar 08, 2011, 05:37 PM |
| 14159 capital (GP), LLC | Director | Mar 04, 2011 | Buy | $25.45 | 1,391 | 35,405 | 144,383 | Mar 08, 2011, 05:37 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Mar 08, 2011 | Buy | $25.13 | 1,826 | 45,887 | 5,603,248 | Mar 08, 2011, 05:33 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Mar 07, 2011 | Buy | $24.99 | 297,340 | 7,430,585 | 5,601,422 | Mar 08, 2011, 05:33 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Mar 04, 2011 | Buy | $25.45 | 50,400 | 1,282,845 | 5,304,082 | Mar 08, 2011, 05:33 PM |
| COLELLA SAMUEL D | Director | Mar 03, 2011 | Sale | $25.45 | 10,571 | 269,032 | 19,358 | Mar 04, 2011, 08:46 PM |
| COLELLA SAMUEL D | Director | Mar 03, 2011 | Sale | $25.45 | 23,749 | 604,412 | 37,552 | Mar 04, 2011, 08:46 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Mar 02, 2011 | Buy | $26.10 | 74,969 | 1,956,372 | 5,253,682 | Mar 02, 2011, 05:24 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Mar 01, 2011 | Buy | $25.56 | 43,212 | 1,104,574 | 5,178,713 | Mar 02, 2011, 05:24 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Feb 28, 2011 | Buy | $25.10 | 42,156 | 1,058,018 | 5,135,501 | Mar 02, 2011, 05:24 PM |
| 14159 capital (GP), LLC | Director | Feb 28, 2011 | Buy | $25.10 | 1,164 | 29,214 | 139,730 | Mar 02, 2011, 05:12 PM |
| 14159 capital (GP), LLC | Director | Mar 02, 2011 | Buy | $26.10 | 2,069 | 53,992 | 142,992 | Mar 02, 2011, 05:12 PM |
| 14159 capital (GP), LLC | Director | Mar 01, 2011 | Buy | $25.56 | 1,193 | 30,495 | 140,923 | Mar 02, 2011, 05:12 PM |
| Shak Steven | Chief Medical Officer | Feb 24, 2011 | Option Exercise | $9.39 | 5,000 | 46,950 | 397,778 | Feb 28, 2011, 02:58 PM |
| Shak Steven | Chief Medical Officer | Feb 24, 2011 | Sale | $23.26 | 5,000 | 116,325 | 392,778 | Feb 28, 2011, 02:58 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Feb 25, 2011 | Buy | $24.04 | 35,078 | 843,196 | 5,093,345 | Feb 25, 2011, 05:20 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Feb 24, 2011 | Buy | $23.44 | 72,542 | 1,700,598 | 5,058,267 | Feb 25, 2011, 05:20 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Feb 23, 2011 | Buy | $22.88 | 50,735 | 1,160,710 | 4,985,725 | Feb 25, 2011, 05:20 PM |
| 14159 capital (GP), LLC | Director | Feb 23, 2011 | Buy | $22.88 | 1,400 | 32,029 | 135,596 | Feb 25, 2011, 05:18 PM |
| 14159 capital (GP), LLC | Director | Feb 25, 2011 | Buy | $24.04 | 968 | 23,269 | 138,566 | Feb 25, 2011, 05:18 PM |
| 14159 capital (GP), LLC | Director | Feb 24, 2011 | Buy | $23.44 | 2,002 | 46,933 | 137,598 | Feb 25, 2011, 05:18 PM |
| Schorno Dean L | CFO | Feb 15, 2011 | Sale | $22.51 | 1,000 | 22,506 | 22,900 | Feb 16, 2011, 04:24 PM |
| Popovits Kimberly J | President and CEO | Feb 15, 2011 | Option Exercise | $9.39 | 4,000 | 37,560 | 300,916 | Feb 16, 2011, 04:22 PM |
| Popovits Kimberly J | President and CEO | Feb 14, 2011 | Option Exercise | $9.39 | 4,000 | 37,560 | 300,916 | Feb 16, 2011, 04:22 PM |
| Popovits Kimberly J | President and CEO | Feb 15, 2011 | Sale | $22.64 | 4,000 | 90,579 | 296,916 | Feb 16, 2011, 04:22 PM |
| Popovits Kimberly J | President and CEO | Feb 14, 2011 | Sale | $22.38 | 4,000 | 89,540 | 296,916 | Feb 16, 2011, 04:22 PM |
| Popovits Kimberly J | President and CEO | Jan 18, 2011 | Option Exercise | $7.20 | 4,000 | 28,791 | 290,916 | Feb 16, 2011, 04:16 PM |
| Popovits Kimberly J | President and CEO | Jan 14, 2011 | Option Exercise | $2.88 | 4,000 | 11,520 | 290,916 | Feb 16, 2011, 04:16 PM |
| Popovits Kimberly J | President and CEO | Jan 18, 2011 | Sale | $21.19 | 4,000 | 84,753 | 286,916 | Feb 16, 2011, 04:16 PM |
| Popovits Kimberly J | President and CEO | Jan 14, 2011 | Sale | $21.11 | 4,000 | 84,446 | 286,916 | Feb 16, 2011, 04:16 PM |
| Scott Randal W | Executive Chairman | Feb 11, 2011 | Sale | $22.28 | 10,000 | 222,820 | 1,601,146 | Feb 14, 2011, 01:54 PM |
| Scott Randal W | Executive Chairman | Feb 10, 2011 | Sale | $22.12 | 10,000 | 221,223 | 1,611,146 | Feb 14, 2011, 01:54 PM |
| Cole G Bradley | COO | Feb 08, 2011 | Option Exercise | $12.28 | 5,000 | 61,423 | 10,250 | Feb 10, 2011, 07:36 PM |
| Popovits Kimberly J | President and CEO | Jan 18, 2011 | Option Exercise | $2.88 | 4,000 | 11,520 | 290,916 | Jan 19, 2011, 05:24 PM |
| Popovits Kimberly J | President and CEO | Jan 14, 2011 | Option Exercise | $2.88 | 4,000 | 11,520 | 290,916 | Jan 19, 2011, 05:24 PM |
| Popovits Kimberly J | President and CEO | Jan 18, 2011 | Sale | $21.19 | 4,000 | 84,753 | 286,916 | Jan 19, 2011, 05:24 PM |
| Popovits Kimberly J | President and CEO | Jan 14, 2011 | Sale | $21.11 | 4,000 | 84,446 | 286,916 | Jan 19, 2011, 05:24 PM |
| Schorno Dean L | CFO | Jan 13, 2011 | Option Exercise | $2.88 | 1,276 | 3,675 | 21,276 | Jan 19, 2011, 04:45 PM |
| Schorno Dean L | CFO | Jan 13, 2011 | Sale | $21.06 | 1,276 | 26,871 | 20,000 | Jan 19, 2011, 04:45 PM |
| Scott Randal W | Executive Chairman | Jan 11, 2011 | Sale | $21.71 | 10,000 | 217,091 | 1,626,646 | Jan 12, 2011, 04:11 PM |
| Scott Randal W | Executive Chairman | Jan 10, 2011 | Sale | $21.75 | 10,000 | 217,502 | 1,636,646 | Jan 12, 2011, 04:11 PM |
| Cole G Bradley | COO | Jan 06, 2011 | Option Exercise | $1.33 | 5,000 | 6,650 | 6,000 | Jan 07, 2011, 08:06 PM |
| Cole G Bradley | COO | Jan 06, 2011 | Sale | $22.13 | 5,000 | 110,652 | 1,000 | Jan 07, 2011, 08:06 PM |
| Popovits Kimberly J | President and CEO | Dec 16, 2010 | Option Exercise | $2.88 | 4,000 | 11,520 | 292,116 | Dec 17, 2010, 05:10 PM |
| Popovits Kimberly J | President and CEO | Dec 15, 2010 | Option Exercise | $2.88 | 4,000 | 11,520 | 292,116 | Dec 17, 2010, 05:10 PM |
| Popovits Kimberly J | President and CEO | Dec 15, 2010 | Sale | $22.68 | 4,000 | 90,726 | 288,116 | Dec 17, 2010, 05:10 PM |
| Popovits Kimberly J | President and CEO | Dec 16, 2010 | Sale | $22.73 | 4,000 | 90,938 | 288,116 | Dec 17, 2010, 05:10 PM |
| Cole G Bradley | COO & CFO | Dec 13, 2010 | Option Exercise | $1.33 | 2,500 | 3,325 | 3,500 | Dec 15, 2010, 05:48 PM |
| Cole G Bradley | COO & CFO | Dec 13, 2010 | Sale | $22.64 | 2,500 | 56,612 | 1,000 | Dec 15, 2010, 05:48 PM |
| Scott Randal W | Executive Chairman | Dec 10, 2010 | Sale | $22.46 | 10,000 | 224,568 | 1,690,646 | Dec 14, 2010, 07:05 PM |
| Scott Randal W | Executive Chairman | Dec 13, 2010 | Sale | $22.47 | 10,000 | 224,669 | 1,680,646 | Dec 14, 2010, 07:05 PM |
| Scott Randal W | Executive Chairman | Nov 19, 2010 | Option Exercise | $10.33 | 50,000 | 516,500 | 1,700,646 | Nov 23, 2010, 03:19 PM |
| Popovits Kimberly J | President and CEO | Nov 15, 2010 | Option Exercise | $2.88 | 4,000 | 11,520 | 292,116 | Nov 17, 2010, 07:21 PM |
| Popovits Kimberly J | President and CEO | Nov 16, 2010 | Option Exercise | $2.88 | 4,000 | 11,520 | 292,116 | Nov 17, 2010, 07:21 PM |
| Popovits Kimberly J | President and CEO | Nov 16, 2010 | Sale | $17.39 | 4,000 | 69,576 | 288,116 | Nov 17, 2010, 07:21 PM |
| Popovits Kimberly J | President and CEO | Nov 15, 2010 | Sale | $17.60 | 4,000 | 70,412 | 288,116 | Nov 17, 2010, 07:21 PM |
| Cole G Bradley | COO & CFO | Nov 11, 2010 | Option Exercise | $1.33 | 2,500 | 3,325 | 3,500 | Nov 12, 2010, 05:10 PM |
| Cole G Bradley | COO & CFO | Nov 11, 2010 | Sale | $18.04 | 2,500 | 45,093 | 1,000 | Nov 12, 2010, 05:10 PM |
| Scott Randal W | Executive Chairman | Nov 11, 2010 | Sale | $18.29 | 10,000 | 182,886 | 1,650,646 | Nov 12, 2010, 05:07 PM |
| Scott Randal W | Executive Chairman | Nov 10, 2010 | Sale | $18.25 | 10,000 | 182,469 | 1,660,646 | Nov 12, 2010, 05:07 PM |
| Scott Randal W | Executive Chairman | Oct 12, 2010 | Sale | $13.85 | 10,000 | 138,545 | 1,670,646 | Oct 13, 2010, 04:28 PM |
| Scott Randal W | Executive Chairman | Oct 11, 2010 | Sale | $14.05 | 10,000 | 140,450 | 1,680,646 | Oct 13, 2010, 04:28 PM |
| Popovits Kimberly J | President and CEO | Sep 15, 2010 | Option Exercise | $2.88 | 3,734 | 10,754 | 291,850 | Sep 16, 2010, 05:13 PM |
| Popovits Kimberly J | President and CEO | Sep 14, 2010 | Option Exercise | $2.88 | 4,000 | 11,520 | 292,116 | Sep 16, 2010, 05:13 PM |
| Popovits Kimberly J | President and CEO | Sep 15, 2010 | Sale | $15.06 | 3,734 | 56,247 | 288,116 | Sep 16, 2010, 05:13 PM |
| Popovits Kimberly J | President and CEO | Sep 14, 2010 | Sale | $15.14 | 4,000 | 60,543 | 288,116 | Sep 16, 2010, 05:13 PM |
| Scott Randal W | Executive Chairman | Sep 13, 2010 | Sale | $15.01 | 10,000 | 150,142 | 1,690,646 | Sep 14, 2010, 05:54 PM |
| Scott Randal W | Executive Chairman | Sep 10, 2010 | Sale | $14.73 | 10,000 | 147,319 | 1,700,646 | Sep 14, 2010, 05:54 PM |
| Cole G Bradley | COO & CFO | Sep 13, 2010 | Option Exercise | $1.33 | 2,500 | 3,325 | 3,500 | Sep 14, 2010, 05:50 PM |
| Cole G Bradley | COO & CFO | Sep 13, 2010 | Sale | $15.01 | 2,500 | 37,513 | 1,000 | Sep 14, 2010, 05:50 PM |
| 14159 capital (GP), LLC | Director | Sep 09, 2010 | Buy | $14.78 | 40 | 591 | 134,196 | Sep 10, 2010, 04:06 PM |
| 14159 capital (GP), LLC | Director | Sep 08, 2010 | Buy | $14.82 | 105 | 1,556 | 134,156 | Sep 10, 2010, 04:06 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Sep 09, 2010 | Buy | $14.78 | 1,460 | 21,585 | 4,934,990 | Sep 10, 2010, 04:04 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Sep 08, 2010 | Buy | $14.82 | 3,801 | 56,337 | 4,933,530 | Sep 10, 2010, 04:04 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Sep 02, 2010 | Buy | $14.54 | 3,969 | 57,699 | 4,929,729 | Sep 02, 2010, 04:33 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Sep 01, 2010 | Buy | $14.44 | 34,578 | 499,331 | 4,925,760 | Sep 02, 2010, 04:33 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Aug 31, 2010 | Buy | $14.47 | 26,919 | 389,584 | 4,891,182 | Sep 02, 2010, 04:33 PM |
| 14159 capital (GP), LLC | Director | Sep 02, 2010 | Buy | $14.54 | 220 | 3,198 | 134,051 | Sep 02, 2010, 04:32 PM |
| 14159 capital (GP), LLC | Director | Sep 01, 2010 | Buy | $14.44 | 1,908 | 27,553 | 133,941 | Sep 02, 2010, 04:32 PM |
| 14159 capital (GP), LLC | Director | Aug 31, 2010 | Buy | $14.47 | 1,486 | 21,506 | 132,987 | Sep 02, 2010, 04:32 PM |
| 14159 capital (GP), LLC | Director | Aug 30, 2010 | Buy | $14.45 | 1,271 | 18,362 | 132,244 | Aug 30, 2010, 05:41 PM |
| 14159 capital (GP), LLC | Director | Aug 27, 2010 | Buy | $14.42 | 1,037 | 14,950 | 130,973 | Aug 30, 2010, 05:41 PM |
| 14159 capital (GP), LLC | Director | Aug 26, 2010 | Buy | $14.24 | 1,107 | 15,766 | 129,936 | Aug 30, 2010, 05:41 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Aug 27, 2010 | Buy | $14.42 | 37,561 | 541,502 | 4,818,216 | Aug 30, 2010, 05:39 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Aug 26, 2010 | Buy | $14.24 | 40,103 | 571,161 | 4,780,655 | Aug 30, 2010, 05:39 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Aug 30, 2010 | Buy | $14.45 | 46,047 | 665,223 | 4,864,263 | Aug 30, 2010, 05:39 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Aug 23, 2010 | Buy | $14.44 | 67,892 | 980,509 | 4,740,552 | Aug 23, 2010, 05:18 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Aug 20, 2010 | Buy | $14.52 | 27,272 | 395,875 | 4,672,660 | Aug 23, 2010, 05:18 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Aug 19, 2010 | Buy | $14.63 | 55,305 | 808,993 | 4,645,388 | Aug 23, 2010, 05:18 PM |
| 14159 capital (GP), LLC | Director | Aug 20, 2010 | Buy | $14.52 | 752 | 10,916 | 126,955 | Aug 23, 2010, 05:17 PM |
| 14159 capital (GP), LLC | Director | Aug 19, 2010 | Buy | $14.63 | 1,527 | 22,337 | 126,203 | Aug 23, 2010, 05:17 PM |
| 14159 capital (GP), LLC | Director | Aug 23, 2010 | Buy | $14.44 | 1,874 | 27,065 | 128,829 | Aug 23, 2010, 05:17 PM |
| Popovits Kimberly J | President and CEO | Aug 17, 2010 | Option Exercise | $2.88 | 4,000 | 11,520 | 292,116 | Aug 19, 2010, 08:34 PM |
| Popovits Kimberly J | President and CEO | Aug 16, 2010 | Option Exercise | $2.88 | 4,000 | 11,520 | 292,116 | Aug 19, 2010, 08:34 PM |
| Popovits Kimberly J | President and CEO | Aug 17, 2010 | Sale | $15.14 | 4,000 | 60,560 | 288,116 | Aug 19, 2010, 08:34 PM |
| Popovits Kimberly J | President and CEO | Aug 16, 2010 | Sale | $15.00 | 4,000 | 60,000 | 288,116 | Aug 19, 2010, 08:34 PM |
| 14159 capital (GP), LLC | Director | Aug 16, 2010 | Buy | $14.99 | 479 | 7,178 | 124,625 | Aug 18, 2010, 04:50 PM |
| 14159 capital (GP), LLC | Director | Aug 18, 2010 | Buy | $15.00 | 51 | 765 | 124,676 | Aug 18, 2010, 04:50 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Aug 18, 2010 | Buy | $15.00 | 1,845 | 27,675 | 4,590,083 | Aug 18, 2010, 04:48 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Aug 16, 2010 | Buy | $14.99 | 17,342 | 259,877 | 4,588,238 | Aug 18, 2010, 04:48 PM |
| Cole G Bradley | COO & CFO | Aug 12, 2010 | Option Exercise | $1.33 | 2,500 | 3,325 | 3,500 | Aug 13, 2010, 06:39 PM |
| Cole G Bradley | COO & CFO | Aug 12, 2010 | Sale | $15.00 | 2,500 | 37,500 | 1,000 | Aug 13, 2010, 06:39 PM |
| 14159 capital (GP), LLC | Director | Aug 12, 2010 | Buy | $14.99 | 836 | 12,529 | 122,837 | Aug 13, 2010, 04:35 PM |
| 14159 capital (GP), LLC | Director | Aug 11, 2010 | Buy | $14.73 | 779 | 11,474 | 122,001 | Aug 13, 2010, 04:35 PM |
| 14159 capital (GP), LLC | Director | Aug 13, 2010 | Buy | $14.84 | 1,309 | 19,425 | 124,146 | Aug 13, 2010, 04:35 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Aug 13, 2010 | Buy | $14.84 | 47,408 | 703,529 | 4,570,896 | Aug 13, 2010, 04:30 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Aug 12, 2010 | Buy | $14.99 | 30,296 | 454,040 | 4,523,488 | Aug 13, 2010, 04:30 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Aug 11, 2010 | Buy | $14.73 | 28,206 | 415,465 | 4,493,192 | Aug 13, 2010, 04:30 PM |
| Scott Randal W | Executive Chairman | Aug 10, 2010 | Sale | $14.73 | 10,000 | 147,319 | 1,720,646 | Aug 12, 2010, 09:54 PM |
| Scott Randal W | Executive Chairman | Aug 11, 2010 | Sale | $14.69 | 10,000 | 146,943 | 1,710,646 | Aug 12, 2010, 09:54 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Aug 10, 2010 | Buy | $14.75 | 56,705 | 836,217 | 4,464,986 | Aug 10, 2010, 05:04 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Aug 09, 2010 | Buy | $14.81 | 62,610 | 927,144 | 4,408,281 | Aug 10, 2010, 05:04 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Aug 06, 2010 | Buy | $14.16 | 44,927 | 636,250 | 4,345,671 | Aug 10, 2010, 05:04 PM |
| 14159 capital (GP), LLC | Director | Aug 10, 2010 | Buy | $14.75 | 1,565 | 23,079 | 121,222 | Aug 10, 2010, 05:00 PM |
| 14159 capital (GP), LLC | Director | Aug 09, 2010 | Buy | $14.81 | 1,728 | 25,589 | 119,657 | Aug 10, 2010, 05:00 PM |
| 14159 capital (GP), LLC | Director | Aug 06, 2010 | Buy | $14.16 | 1,240 | 17,561 | 117,929 | Aug 10, 2010, 05:00 PM |
| Baker Joffre | Chief Scientific Officer | Aug 09, 2010 | Sale | $14.75 | 4,629 | 68,278 | 126,975 | Aug 09, 2010, 07:36 PM |
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