VIVUS, Inc.. (VVUS) NASDAQ
$0.47 - (-)
Market Cap: $8.34M
As of 07/16/20 12:00 AM EDT. Market closed.
VIVUS, Inc.. (VVUS)
NASDAQ
$0.47
- (-)
Market Cap: $8.34M
As of 07/16/20 12:00 AM EDT. Market closed.
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VIVUS, Inc. engages in the development and commercialization of novel therapeutic products. The firm's products are indicated for the treatment of obese and overweight patients, exocrine pancreatic insufficiency, and erectile dysfunction. Its products include PANCREAZE, Qsymia, and STENDRA/SPEDRA. The company was founded by Virgil A. Place in April 16, 1991 and is headquartered in Campbell, ... read more
VIVUS, Inc. engages in the development and commercialization of novel therapeutic products. The firm's products are indicated for the treatment of obese and overweight patients, exocrine pancreatic insufficiency, and erectile dysfunction. Its products include PANCREAZE, Qsymia, and STENDRA/SPEDRA. The company was founded by Virgil A. Place in April 16, 1991 and is headquartered in Campbell, CA. read less
COMPANY PROFILE
Sector
Health Technology
Industry
Pharmaceuticals: Other
CEO
John P. Amos
Full Time Employees
59
Sector
Health Technology
Industry
Pharmaceuticals: Other
CEO
John P. Amos
Full Time Employees
59
CEO Compensation (Base)
$696,600
URL
Address
900 East Hamilton Avenue, CA, Campbell, 95008.
PRICE CHART FOR VIVUS, INC.
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NEWS
INSIDEARBITRAGE ARTICLES
KEY STATS
Open
-
Previous Close
$0.47
Days Range
- - -
52 week range
$0.44 - $4.75
Volume
0
Avg. Volume (30 days)
1,679,610
Market Cap
$8.34M
Dividend Yield
-
P/E
-
Shares Outstanding
17,867,700
Open
-
Previous Close
$0.47
Days Range
- - -
52 week range
$0.44 - $4.75
Volume
0
Avg. Volume (30 days)
1,679,610
Market Cap
$8.34M
Dividend Yield
-
P/E
-
Shares Outstanding
17,867,700
FINANCIAL STATEMENTS FOR VIVUS, INC.
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INSIDER TRANSACTIONS FOR VIVUS, INC.
| Owner | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| Oki Mark K | SVP, CFO, CAO | Nov 14, 2019 | Option Exercise | $2.38 | 700 | 1,666 | 12,100 | Nov 18, 2019, 04:51 PM |
| Varghese Santosh T | Chief Medical Officer | Nov 14, 2019 | Option Exercise | $2.38 | 700 | 1,666 | 9,242 | Nov 18, 2019, 04:51 PM |
| Oki Mark K | SVP, CFO, CAO | May 14, 2019 | Option Exercise | $2.84 | 700 | 1,988 | 11,400 | May 15, 2019, 04:59 PM |
| Varghese Santosh T | Chief Medical Officer | May 14, 2019 | Option Exercise | $2.84 | 700 | 1,988 | 8,542 | May 15, 2019, 04:51 PM |
| Amos John P. | Chief Executive Officer | Mar 01, 2019 | Buy | $4.85 | 11,000 | 53,384 | 181,850 | Apr 10, 2019, 07:06 PM |
| Roberts Eric W | Director | Feb 28, 2019 | Buy | $4.82 | 8,500 | 40,982 | 16,660 | Mar 04, 2019, 04:45 PM |
| Amos John P. | Chief Executive Officer | Mar 01, 2019 | Buy | $4.85 | 11,000 | 53,384 | 1,719,500 | Mar 04, 2019, 12:00 AM |
| Varghese Santosh T | Chief Medical Officer | Nov 14, 2018 | Option Exercise | $2.71 | 700 | 1,897 | 7,842 | Nov 16, 2018, 04:18 PM |
| Oki Mark K | Chief Financial Officer & CAO | Nov 14, 2018 | Option Exercise | $2.71 | 700 | 1,897 | 10,700 | Nov 16, 2018, 04:14 PM |
| Oki Mark K | Chief Financial Officer & CAO | Nov 06, 2018 | Buy | $4.07 | 10,000 | 40,700 | 10,000 | Nov 07, 2018, 04:10 PM |
| Shaw Allan | Director | Oct 01, 2018 | Option Exercise | $5.63 | 43 | 242 | 6,389 | Oct 03, 2018, 06:42 PM |
| Roberts Eric W | Director | Oct 01, 2018 | Option Exercise | $5.63 | 43 | 242 | 8,160 | Oct 03, 2018, 06:39 PM |
| Shaw Allan | Director | Aug 15, 2018 | Option Exercise | $0.63 | 438 | 276 | 62,928 | Aug 16, 2018, 04:37 PM |
| Roberts Eric W | Director | Aug 15, 2018 | Option Exercise | $0.63 | 438 | 276 | 80,632 | Aug 16, 2018, 04:31 PM |
| Roberts Eric W | Director | Jul 15, 2018 | Option Exercise | $0.77 | 439 | 338 | 79,681 | Jul 17, 2018, 04:17 PM |
| Shaw Allan | Director | Jul 15, 2018 | Option Exercise | $0.77 | 439 | 338 | 61,977 | Jul 17, 2018, 04:11 PM |
| ROSENMAN HERM | Director | Jun 29, 2018 | Option Exercise | $0.70 | 25,000 | 17,500 | 311,671 | Jul 03, 2018, 04:10 PM |
| Shaw Allan | Director | Jun 15, 2018 | Option Exercise | $0.84 | 438 | 368 | 61,027 | Jun 19, 2018, 04:21 PM |
| Roberts Eric W | Director | Jun 15, 2018 | Option Exercise | $0.84 | 438 | 368 | 78,731 | Jun 19, 2018, 04:18 PM |
| ROSENMAN HERM | Director | Jun 01, 2018 | Buy | $0.77 | 50,000 | 38,500 | 50,000 | Jun 05, 2018, 09:31 PM |
| ROSENMAN HERM | Director | May 29, 2018 | Buy | $0.79 | 50,000 | 39,500 | 286,671 | May 31, 2018, 04:33 PM |
| ROSENMAN HERM | Director | May 21, 2018 | Option Exercise | $0.70 | 75,000 | 52,500 | 136,671 | May 23, 2018, 05:05 PM |
| ROSENMAN HERM | Director | May 21, 2018 | Buy | $0.81 | 100,000 | 81,000 | 236,671 | May 23, 2018, 05:05 PM |
| Amos John P. | Chief Executive Officer | May 18, 2018 | Buy | $0.77 | 270,000 | 208,089 | 1,710,000 | May 22, 2018, 05:08 PM |
| Amos John P. | Chief Executive Officer | May 18, 2018 | Sale | $0.77 | 1,500 | 1,156 | 1,708,500 | May 22, 2018, 05:08 PM |
| Amos John P. | Chief Executive Officer | May 17, 2018 | Buy | $0.69 | 360,000 | 249,228 | 1,440,000 | May 21, 2018, 07:16 PM |
| Shaw Allan | Director | May 15, 2018 | Option Exercise | $0.52 | 438 | 228 | 60,076 | May 17, 2018, 05:10 PM |
| Roberts Eric W | Director | May 15, 2018 | Option Exercise | $0.52 | 497 | 258 | 77,780 | May 17, 2018, 05:09 PM |
| Amos John P. | Chief Executive Officer | May 16, 2018 | Buy | $0.58 | 270,000 | 156,546 | 1,080,000 | May 17, 2018, 05:00 PM |
| Amos John P. | Chief Executive Officer | May 15, 2018 | Buy | $0.54 | 270,000 | 146,529 | 810,000 | May 17, 2018, 05:00 PM |
| Amos John P. | Chief Executive Officer | May 14, 2018 | Buy | $0.51 | 270,000 | 138,672 | 540,000 | May 15, 2018, 07:39 PM |
| Amos John P. | Chief Executive Officer | May 11, 2018 | Buy | $0.52 | 270,000 | 139,914 | 270,000 | May 15, 2018, 07:39 PM |
| Shaw Allan | Director | Apr 15, 2018 | Option Exercise | $0.42 | 438 | 184 | 59,125 | Apr 17, 2018, 04:18 PM |
| Roberts Eric W | Director | Apr 15, 2018 | Option Exercise | $0.42 | 438 | 184 | 76,888 | Apr 17, 2018, 04:17 PM |
| Varghese Santosh T | Chief Medical Officer | Apr 03, 2018 | Sale | $0.34 | 390 | 132 | 71,415 | Apr 04, 2018, 04:22 PM |
| Slebir John L | SVP, Business Development & GC | Apr 01, 2018 | Option Exercise | $0.36 | 559 | 199 | 134,010 | Apr 03, 2018, 04:18 PM |
| Shaw Allan | Director | Mar 15, 2018 | Option Exercise | $0.48 | 438 | 210 | 58,174 | Mar 19, 2018, 04:21 PM |
| Roberts Eric W | Director | Mar 15, 2018 | Option Exercise | $0.48 | 438 | 210 | 75,937 | Mar 19, 2018, 04:18 PM |
| Shaw Allan | Director | Feb 15, 2018 | Option Exercise | $0.46 | 438 | 201 | 57,223 | Feb 20, 2018, 04:26 PM |
| Roberts Eric W | Director | Feb 15, 2018 | Option Exercise | $0.46 | 497 | 229 | 74,986 | Feb 20, 2018, 12:00 AM |
| Varghese Santosh T | Chief Medical Officer | Jan 31, 2018 | Sale | $0.43 | 491 | 211 | 71,805 | Feb 01, 2018, 04:19 PM |
| Slebir John L | SVP, Business Development & GC | Jan 28, 2018 | Option Exercise | $0.46 | 614 | 282 | 134,569 | Jan 30, 2018, 06:40 PM |
| Shaw Allan | Director | Jan 15, 2018 | Option Exercise | $0.51 | 480 | 245 | 56,272 | Jan 17, 2018, 04:18 PM |
| Roberts Eric W | Director | Jan 15, 2018 | Option Exercise | $0.51 | 539 | 275 | 74,094 | Jan 17, 2018, 04:18 PM |
| Fischer Seth H. Z. | Consultant | Jan 01, 2018 | Option Exercise | $0.50 | 2,102 | 1,051 | 633,978 | Jan 03, 2018, 07:11 PM |
| Varghese Santosh T | Chief Medical Officer | Jan 01, 2018 | Sale | $0.51 | 444 | 226 | 72,296 | Jan 03, 2018, 07:09 PM |
| Slebir John L | SVP, Business Development & GC | Jan 01, 2018 | Option Exercise | $0.50 | 710 | 355 | 135,183 | Jan 03, 2018, 07:07 PM |
| Shaw Allan | Director | Dec 15, 2017 | Option Exercise | $0.53 | 481 | 255 | 55,363 | Dec 19, 2017, 04:23 PM |
| Roberts Eric W | Director | Dec 15, 2017 | Option Exercise | $0.53 | 540 | 286 | 73,244 | Dec 19, 2017, 04:21 PM |
| Shaw Allan | Director | Nov 15, 2017 | Option Exercise | $0.66 | 481 | 315 | 54,455 | Nov 17, 2017, 04:52 PM |
| Roberts Eric W | Director | Nov 15, 2017 | Option Exercise | $0.66 | 540 | 354 | 72,395 | Nov 17, 2017, 04:52 PM |
| Shaw Allan | Director | Oct 27, 2017 | Option Exercise | $0.70 | 4,327 | 3,029 | 53,547 | Oct 31, 2017, 05:50 PM |
| ROSENMAN HERM | Director | Oct 27, 2017 | Option Exercise | $0.70 | 4,403 | 3,082 | 61,671 | Oct 31, 2017, 05:48 PM |
| Roberts Eric W | Director | Oct 27, 2017 | Option Exercise | $0.70 | 4,859 | 3,401 | 71,546 | Oct 31, 2017, 05:46 PM |
| Plutzky Jorge MD | Director | Oct 27, 2017 | Option Exercise | $0.70 | 3,762 | 2,633 | 81,159 | Oct 31, 2017, 05:44 PM |
| Norton David Y | Director | Oct 27, 2017 | Option Exercise | $0.70 | 3,125 | 2,187 | 67,120 | Oct 31, 2017, 05:43 PM |
| Roberts Eric W | Director | Oct 16, 2017 | Option Exercise | $0.86 | 540 | 464 | 63,905 | Oct 17, 2017, 04:44 PM |
| Shaw Allan | Director | Oct 16, 2017 | Option Exercise | $0.86 | 480 | 413 | 45,374 | Oct 17, 2017, 04:43 PM |
| Varghese Santosh T | Chief Medical Officer | Oct 03, 2017 | Sale | $0.97 | 434 | 421 | 72,740 | Oct 04, 2017, 04:42 PM |
| Shaw Allan | Director | Sep 15, 2017 | Option Exercise | $1.00 | 481 | 481 | 44,465 | Sep 19, 2017, 04:25 PM |
| Roberts Eric W | Director | Sep 15, 2017 | Option Exercise | $1.00 | 540 | 540 | 63,056 | Sep 19, 2017, 04:22 PM |
| Shaw Allan | Director | Aug 15, 2017 | Option Exercise | $1.01 | 480 | 485 | 43,557 | Aug 17, 2017, 04:20 PM |
| Roberts Eric W | Director | Aug 15, 2017 | Option Exercise | $1.01 | 539 | 544 | 62,207 | Aug 17, 2017, 04:18 PM |
| Shaw Allan | Director | Aug 08, 2017 | Option Exercise | $1.01 | 4,327 | 4,370 | 42,649 | Aug 10, 2017, 04:21 PM |
| ROSENMAN HERM | Director | Aug 08, 2017 | Option Exercise | $1.01 | 4,403 | 4,447 | 53,574 | Aug 10, 2017, 04:19 PM |
| Roberts Eric W | Director | Aug 08, 2017 | Option Exercise | $1.01 | 4,859 | 4,908 | 61,358 | Aug 10, 2017, 04:18 PM |
| Plutzky Jorge MD | Director | Aug 08, 2017 | Option Exercise | $1.01 | 3,762 | 3,800 | 72,421 | Aug 10, 2017, 04:17 PM |
| Norton David Y | Director | Aug 08, 2017 | Option Exercise | $1.01 | 3,125 | 3,156 | 57,745 | Aug 10, 2017, 04:16 PM |
| Roberts Eric W | Director | Jul 15, 2017 | Option Exercise | $1.27 | 540 | 686 | 53,717 | Jul 18, 2017, 05:37 PM |
| Shaw Allan | Director | Jul 15, 2017 | Option Exercise | $1.27 | 481 | 611 | 34,476 | Jul 18, 2017, 05:35 PM |
| Varghese Santosh T | Chief Medical Officer | Jul 03, 2017 | Sale | $1.23 | 423 | 520 | 73,174 | Jul 05, 2017, 04:35 PM |
| Shaw Allan | Director | Jun 15, 2017 | Option Exercise | $1.17 | 4,807 | 5,624 | 33,568 | Jun 19, 2017, 06:54 PM |
| ROSENMAN HERM | Director | Jun 15, 2017 | Option Exercise | $1.17 | 4,403 | 5,152 | 45,477 | Jun 19, 2017, 06:54 PM |
| Roberts Eric W | Director | Jun 15, 2017 | Option Exercise | $1.17 | 5,398 | 6,316 | 52,868 | Jun 19, 2017, 06:53 PM |
| Plutzky Jorge MD | Director | Jun 15, 2017 | Option Exercise | $1.17 | 3,762 | 4,402 | 63,683 | Jun 19, 2017, 06:52 PM |
| Norton David Y | Director | Jun 15, 2017 | Option Exercise | $1.17 | 3,125 | 3,656 | 48,370 | Jun 19, 2017, 06:52 PM |
| Shaw Allan | Director | Apr 15, 2017 | Option Exercise | $1.03 | 481 | 495 | 24,486 | Apr 18, 2017, 05:47 PM |
| Roberts Eric W | Director | Apr 15, 2017 | Option Exercise | $1.03 | 540 | 556 | 44,377 | Apr 18, 2017, 05:46 PM |
| Varghese Santosh T | Chief Medical Officer | Apr 04, 2017 | Sale | $1.08 | 440 | 475 | 73,597 | Apr 06, 2017, 06:33 PM |
| Roberts Eric W | Director | Mar 15, 2017 | Option Exercise | $1.11 | 539 | 598 | 43,528 | Mar 17, 2017, 11:16 AM |
| Shaw Allan | Director | Mar 15, 2017 | Option Exercise | $1.11 | 480 | 533 | 23,578 | Mar 17, 2017, 11:15 AM |
| NORTH TIDE CAPITAL, LLC | 10% Owner | Mar 10, 2017 | Sale | $1.17 | 77,000 | 90,244 | 10,466,700 | Mar 10, 2017, 05:24 PM |
| NORTH TIDE CAPITAL, LLC | 10% Owner | Mar 09, 2017 | Sale | $1.21 | 722,400 | 873,249 | 11,216,100 | Mar 10, 2017, 05:24 PM |
| NORTH TIDE CAPITAL, LLC | 10% Owner | Mar 08, 2017 | Sale | $1.05 | 350,000 | 368,340 | 11,266,100 | Mar 10, 2017, 05:24 PM |
| NORTH TIDE CAPITAL, LLC | 10% Owner | Mar 03, 2017 | Sale | $1.11 | 32,900 | 36,363 | 11,807,200 | Mar 07, 2017, 05:18 PM |
| NORTH TIDE CAPITAL, LLC | 10% Owner | Mar 07, 2017 | Sale | $1.08 | 145,100 | 156,151 | 11,656,100 | Mar 07, 2017, 05:18 PM |
| NORTH TIDE CAPITAL, LLC | 10% Owner | Mar 06, 2017 | Sale | $1.10 | 14,800 | 16,230 | 11,766,000 | Mar 07, 2017, 05:18 PM |
| NORTH TIDE CAPITAL, LLC | 10% Owner | Mar 02, 2017 | Sale | $1.13 | 20,000 | 22,500 | 11,808,900 | Mar 02, 2017, 05:16 PM |
| NORTH TIDE CAPITAL, LLC | 10% Owner | Mar 01, 2017 | Sale | $1.13 | 114,600 | 130,046 | 11,870,900 | Mar 02, 2017, 05:16 PM |
| NORTH TIDE CAPITAL, LLC | 10% Owner | Feb 28, 2017 | Sale | $1.12 | 25,500 | 28,593 | 11,943,500 | Mar 02, 2017, 05:16 PM |
| NORTH TIDE CAPITAL, LLC | 10% Owner | Feb 27, 2017 | Sale | $1.13 | 150,000 | 168,965 | 12,012,000 | Feb 27, 2017, 05:42 PM |
| NORTH TIDE CAPITAL, LLC | 10% Owner | Feb 24, 2017 | Sale | $1.14 | 33,000 | 37,505 | 12,119,000 | Feb 27, 2017, 05:42 PM |
| NORTH TIDE CAPITAL, LLC | 10% Owner | Feb 23, 2017 | Sale | $1.16 | 150,000 | 174,015 | 12,152,000 | Feb 27, 2017, 05:42 PM |
| NORTH TIDE CAPITAL, LLC | 10% Owner | Feb 22, 2017 | Sale | $1.11 | 109,336 | 121,582 | 12,302,000 | Feb 22, 2017, 04:52 PM |
| NORTH TIDE CAPITAL, LLC | 10% Owner | Feb 21, 2017 | Sale | $1.10 | 52,164 | 57,610 | 12,411,336 | Feb 22, 2017, 04:52 PM |
| NORTH TIDE CAPITAL, LLC | 10% Owner | Feb 17, 2017 | Sale | $1.11 | 300 | 334 | 12,463,500 | Feb 22, 2017, 04:52 PM |
| Shaw Allan | Director | Feb 15, 2017 | Option Exercise | $1.10 | 480 | 528 | 22,669 | Feb 17, 2017, 04:11 PM |
| Roberts Eric W | Director | Feb 15, 2017 | Option Exercise | $1.10 | 539 | 593 | 42,678 | Feb 17, 2017, 04:10 PM |
| NORTH TIDE CAPITAL, LLC | 10% Owner | Feb 15, 2017 | Sale | $1.11 | 40,090 | 44,500 | 12,613,800 | Feb 16, 2017, 05:35 PM |
| NORTH TIDE CAPITAL, LLC | 10% Owner | Feb 14, 2017 | Sale | $1.10 | 115,000 | 126,500 | 12,653,890 | Feb 16, 2017, 05:35 PM |
| NORTH TIDE CAPITAL, LLC | 10% Owner | Feb 16, 2017 | Sale | $1.10 | 150,000 | 165,250 | 12,593,800 | Feb 16, 2017, 05:35 PM |
| NORTH TIDE CAPITAL, LLC | 10% Owner | Feb 13, 2017 | Sale | $1.10 | 67,000 | 74,022 | 12,768,890 | Feb 13, 2017, 05:13 PM |
| NORTH TIDE CAPITAL, LLC | 10% Owner | Feb 10, 2017 | Sale | $1.11 | 46,008 | 50,839 | 12,835,890 | Feb 13, 2017, 05:13 PM |
| NORTH TIDE CAPITAL, LLC | 10% Owner | Feb 09, 2017 | Sale | $1.11 | 63,402 | 70,421 | 12,881,898 | Feb 13, 2017, 05:13 PM |
| Plutzky Jorge MD | Director | Feb 08, 2017 | Option Exercise | $1.08 | 3,762 | 4,063 | 54,945 | Feb 10, 2017, 04:05 PM |
| Roberts Eric W | Director | Feb 08, 2017 | Option Exercise | $1.08 | 4,859 | 5,248 | 41,828 | Feb 10, 2017, 04:04 PM |
| ROSENMAN HERM | Director | Feb 08, 2017 | Option Exercise | $1.08 | 4,403 | 4,755 | 37,380 | Feb 10, 2017, 04:03 PM |
| Shaw Allan | Director | Feb 08, 2017 | Option Exercise | $1.08 | 4,327 | 4,673 | 21,760 | Feb 10, 2017, 04:03 PM |
| Norton David Y | Director | Feb 08, 2017 | Option Exercise | $1.08 | 3,125 | 3,375 | 38,995 | Feb 10, 2017, 04:02 PM |
| NORTH TIDE CAPITAL, LLC | 10% Owner | Feb 08, 2017 | Sale | $1.06 | 529,300 | 561,742 | 12,966,551 | Feb 08, 2017, 05:24 PM |
| NORTH TIDE CAPITAL, LLC | 10% Owner | Feb 07, 2017 | Sale | $1.11 | 6,200 | 6,861 | 13,474,600 | Feb 08, 2017, 05:24 PM |
| NORTH TIDE CAPITAL, LLC | 10% Owner | Feb 06, 2017 | Sale | $1.10 | 28,027 | 30,942 | 13,480,800 | Feb 08, 2017, 05:24 PM |
| NORTH TIDE CAPITAL, LLC | 10% Owner | Feb 02, 2017 | Sale | $1.13 | 3,200 | 3,616 | 13,562,260 | Feb 03, 2017, 04:40 PM |
| NORTH TIDE CAPITAL, LLC | 10% Owner | Feb 01, 2017 | Sale | $1.13 | 22,000 | 24,941 | 13,586,460 | Feb 03, 2017, 04:40 PM |
| NORTH TIDE CAPITAL, LLC | 10% Owner | Feb 03, 2017 | Sale | $1.12 | 53,433 | 59,690 | 13,508,827 | Feb 03, 2017, 04:40 PM |
| Varghese Santosh T | Chief Medical Officer | Jan 28, 2017 | Sale | $1.11 | 429 | 476 | 74,037 | Jan 31, 2017, 06:43 PM |
| Roberts Eric W | Director | Jan 15, 2017 | Option Exercise | $1.20 | 539 | 647 | 34,187 | Jan 18, 2017, 04:07 PM |
| Shaw Allan | Director | Jan 15, 2017 | Option Exercise | $1.20 | 539 | 647 | 13,587 | Jan 18, 2017, 04:06 PM |
| Sris Mayu | Resigned as Director 1/16/2017 | Jan 15, 2017 | Option Exercise | $1.20 | 347 | 416 | 16,668 | Jan 18, 2017, 04:05 PM |
| Sris Mayu | Resigned as Director 1/16/2017 | Jan 16, 2017 | Option Exercise | $1.20 | 2,083 | 2,500 | 22,918 | Jan 18, 2017, 04:05 PM |
| Varghese Santosh T | Chief Medical Officer | Dec 31, 2016 | Sale | $1.12 | 13,790 | 15,478 | 74,830 | Jan 04, 2017, 06:48 PM |
| Shaw Allan | Director | Dec 15, 2016 | Option Exercise | $1.38 | 539 | 744 | 12,737 | Dec 19, 2016, 05:17 PM |
| Sris Mayu | Director | Dec 15, 2016 | Option Exercise | $1.38 | 347 | 479 | 15,626 | Dec 19, 2016, 05:16 PM |
| Roberts Eric W | Director | Dec 15, 2016 | Option Exercise | $1.38 | 539 | 744 | 33,337 | Dec 19, 2016, 05:14 PM |
| Sris Mayu | Director | Nov 15, 2016 | Option Exercise | $1.10 | 347 | 382 | 14,584 | Nov 16, 2016, 04:56 PM |
| Shaw Allan | Director | Nov 15, 2016 | Option Exercise | $1.10 | 539 | 593 | 11,887 | Nov 16, 2016, 04:55 PM |
| Roberts Eric W | Director | Nov 15, 2016 | Option Exercise | $1.10 | 539 | 593 | 32,487 | Nov 16, 2016, 04:52 PM |
| Plutzky Jorge MD | Director | Oct 31, 2016 | Option Exercise | $1.05 | 940 | 987 | 46,207 | Nov 01, 2016, 04:38 PM |
| ROSENMAN HERM | Director | Oct 31, 2016 | Option Exercise | $1.05 | 1,100 | 1,155 | 29,283 | Nov 01, 2016, 04:33 PM |
| Norton David Y | Director | Oct 31, 2016 | Option Exercise | $1.05 | 781 | 820 | 29,620 | Nov 01, 2016, 04:29 PM |
| Sris Mayu | Director | Oct 15, 2016 | Option Exercise | $1.06 | 347 | 368 | 13,542 | Oct 18, 2016, 04:45 PM |
| Roberts Eric W | Director | Oct 15, 2016 | Option Exercise | $1.06 | 540 | 572 | 31,637 | Oct 18, 2016, 04:42 PM |
| Shaw Allan | Director | Oct 15, 2016 | Option Exercise | $1.06 | 540 | 572 | 11,037 | Oct 18, 2016, 04:40 PM |
| Varghese Santosh T | Chief Medical Officer | Oct 01, 2016 | Sale | $1.14 | 710 | 809 | 88,610 | Oct 04, 2016, 07:35 PM |
| Plutzky Jorge MD | Director | Sep 30, 2016 | Option Exercise | $1.14 | 940 | 1,072 | 44,022 | Oct 04, 2016, 07:31 PM |
| ROSENMAN HERM | Director | Sep 30, 2016 | Option Exercise | $1.14 | 1,100 | 1,254 | 27,258 | Oct 04, 2016, 07:29 PM |
| Norton David Y | Director | Sep 30, 2016 | Option Exercise | $1.14 | 781 | 890 | 27,276 | Oct 04, 2016, 07:27 PM |
| Shaw Allan | Director | Sep 15, 2016 | Option Exercise | $1.06 | 540 | 572 | 10,188 | Sep 19, 2016, 05:03 PM |
| Roberts Eric W | Director | Sep 15, 2016 | Option Exercise | $1.06 | 540 | 572 | 30,788 | Sep 19, 2016, 05:02 PM |
| Sris Mayu | Director | Sep 15, 2016 | Option Exercise | $1.06 | 347 | 368 | 12,500 | Sep 19, 2016, 05:02 PM |
| Plutzky Jorge MD | Director | Aug 31, 2016 | Option Exercise | $1.06 | 949 | 1,006 | 41,837 | Sep 02, 2016, 04:39 PM |
| ROSENMAN HERM | Director | Aug 31, 2016 | Option Exercise | $1.06 | 1,111 | 1,178 | 25,233 | Sep 02, 2016, 04:38 PM |
| Norton David Y | Director | Aug 31, 2016 | Option Exercise | $1.06 | 788 | 835 | 24,932 | Sep 02, 2016, 04:38 PM |
| Roberts Eric W | Director | Aug 15, 2016 | Option Exercise | $1.09 | 540 | 589 | 29,939 | Aug 17, 2016, 04:56 PM |
| Shaw Allan | Director | Aug 15, 2016 | Option Exercise | $1.09 | 540 | 589 | 9,339 | Aug 17, 2016, 04:55 PM |
| Sris Mayu | Director | Aug 15, 2016 | Option Exercise | $1.09 | 347 | 378 | 11,458 | Aug 17, 2016, 04:55 PM |
| Varghese Santosh T | Chief Medical Officer | Aug 02, 2016 | Sale | $1.07 | 12,559 | 13,438 | 88,966 | Aug 02, 2016, 07:07 PM |
| ROSENMAN HERM | Director | Jul 31, 2016 | Option Exercise | $1.07 | 1,100 | 1,177 | 23,219 | Aug 02, 2016, 07:07 PM |
| Plutzky Jorge MD | Director | Jul 31, 2016 | Option Exercise | $1.07 | 940 | 1,006 | 39,661 | Aug 02, 2016, 07:06 PM |
| Norton David Y | Director | Jul 31, 2016 | Option Exercise | $1.07 | 781 | 836 | 22,595 | Aug 02, 2016, 07:05 PM |
| Sris Mayu | Director | Jul 15, 2016 | Option Exercise | $1.15 | 347 | 399 | 10,416 | Jul 19, 2016, 05:27 PM |
| Shaw Allan | Director | Jul 15, 2016 | Option Exercise | $1.15 | 540 | 621 | 8,490 | Jul 19, 2016, 05:26 PM |
| Roberts Eric W | Director | Jul 15, 2016 | Option Exercise | $1.15 | 540 | 621 | 29,090 | Jul 19, 2016, 05:25 PM |
| Varghese Santosh T | VP, Medical & Reg Affairs | Jul 01, 2016 | Sale | $1.21 | 366 | 443 | 101,525 | Jul 06, 2016, 05:12 PM |
| ROSENMAN HERM | Director | Jun 30, 2016 | Option Exercise | $1.12 | 1,100 | 1,232 | 21,194 | Jul 05, 2016, 05:16 PM |
| Plutzky Jorge MD | Director | Jun 30, 2016 | Option Exercise | $1.12 | 940 | 1,053 | 37,476 | Jul 05, 2016, 05:15 PM |
| Norton David Y | Director | Jun 30, 2016 | Option Exercise | $1.12 | 781 | 875 | 20,251 | Jul 05, 2016, 05:14 PM |
| Sris Mayu | Director | Jun 15, 2016 | Option Exercise | $1.19 | 347 | 413 | 9,374 | Jun 17, 2016, 04:23 PM |
| ROSENMAN HERM | Director | May 30, 2016 | Option Exercise | $1.23 | 7,706 | 9,478 | 19,169 | Jun 01, 2016, 04:40 PM |
| Plutzky Jorge MD | Director | May 30, 2016 | Option Exercise | $1.23 | 6,584 | 8,098 | 35,291 | Jun 01, 2016, 04:39 PM |
| Norton David Y | Director | May 30, 2016 | Option Exercise | $1.23 | 5,468 | 6,726 | 17,907 | Jun 01, 2016, 04:38 PM |
| Sris Mayu | Director | May 15, 2016 | Option Exercise | $1.16 | 2,777 | 3,221 | 8,333 | May 17, 2016, 04:37 PM |
| Shaw Allan | Director | May 15, 2016 | Option Exercise | $1.16 | 4,318 | 5,009 | 6,792 | May 17, 2016, 04:35 PM |
| Roberts Eric W | Director | May 15, 2016 | Option Exercise | $1.16 | 4,318 | 5,009 | 27,392 | May 17, 2016, 04:33 PM |
| Slebir John L | SVP, Business Development & GC | Jul 01, 2015 | Sale | $2.20 | 9,933 | 21,861 | 59,893 | Apr 20, 2016, 05:04 PM |
| Slebir John L | SVP, Business Development & GC | Jan 01, 2015 | Sale | $3.04 | 2,973 | 9,038 | 44,555 | Apr 20, 2016, 05:02 PM |
| MARSH GUY P | VP, US Operations & GM | Jan 29, 2015 | Sale | $3.04 | 633 | 1,924 | 30,854 | Apr 20, 2016, 04:58 PM |
| Day Wesley | VP, Clinical Development | Jan 01, 2015 | Sale | $3.04 | 2,549 | 7,749 | 46,569 | Apr 20, 2016, 04:44 PM |
| Varghese Santosh T | Chief Medical Officer | Apr 07, 2016 | Sale | $1.65 | 329 | 543 | 101,891 | Apr 11, 2016, 09:33 PM |
| Varghese Santosh T | Chief Medical Officer | Jan 13, 2016 | Sale | $0.95 | 1,553 | 1,475 | 102,220 | Apr 11, 2016, 09:31 PM |
| Varghese Santosh T | VP, Medical & Reg Affairs | Jul 01, 2015 | Sale | $2.20 | 8,514 | 18,738 | 35,373 | Apr 11, 2016, 09:29 PM |
| NORTH TIDE CAPITAL, LLC | 10% Owner | Apr 01, 2016 | Buy | $1.40 | 2,160 | 3,028 | 13,587,460 | Apr 05, 2016, 04:08 PM |
| NORTH TIDE CAPITAL, LLC | 10% Owner | Mar 31, 2016 | Buy | $1.36 | 172,300 | 234,225 | 13,585,300 | Mar 31, 2016, 05:15 PM |
| NORTH TIDE CAPITAL, LLC | 10% Owner | Mar 30, 2016 | Buy | $1.25 | 100,000 | 125,450 | 13,413,000 | Mar 31, 2016, 05:15 PM |
| NORTH TIDE CAPITAL, LLC | 10% Owner | Mar 29, 2016 | Buy | $1.21 | 111,000 | 133,843 | 13,313,000 | Mar 31, 2016, 05:15 PM |
| NORTH TIDE CAPITAL, LLC | 10% Owner | Mar 24, 2016 | Buy | $1.09 | 25,000 | 27,242 | 13,025,000 | Mar 28, 2016, 04:46 PM |
| NORTH TIDE CAPITAL, LLC | 10% Owner | Mar 28, 2016 | Buy | $1.13 | 177,000 | 199,390 | 13,202,000 | Mar 28, 2016, 04:46 PM |
| NORTH TIDE CAPITAL, LLC | 10% Owner | Mar 16, 2016 | Buy | $1.20 | 151,000 | 180,687 | 13,000,000 | Mar 16, 2016, 04:52 PM |
| NORTH TIDE CAPITAL, LLC | 10% Owner | Mar 15, 2016 | Buy | $1.21 | 250,460 | 303,507 | 12,849,000 | Mar 16, 2016, 04:52 PM |
| NORTH TIDE CAPITAL, LLC | 10% Owner | Mar 14, 2016 | Buy | $1.21 | 98,540 | 119,499 | 12,598,540 | Mar 16, 2016, 04:52 PM |
| Varghese Santosh T | VP, Medical & Reg Affairs | Jul 01, 2015 | Sale | $2.32 | 7,899 | 18,326 | 41,234 | Jul 06, 2015, 05:54 PM |
| Slebir John L | SVP, Business Development & GC | Jul 01, 2015 | Sale | $2.32 | 9,215 | 21,379 | 63,584 | Jul 06, 2015, 05:51 PM |
| Day Wesley | VP, Clinical Development | Jul 01, 2015 | Sale | $2.32 | 7,881 | 18,284 | 49,118 | Jul 06, 2015, 05:48 PM |
| Day Wesley | VP, Clinical Development | Jan 29, 2015 | Sale | $2.78 | 472 | 1,312 | 56,999 | Jan 30, 2015, 04:15 PM |
| Slebir John L | SVP, Business Development & GC | Jan 29, 2015 | Sale | $2.78 | 630 | 1,751 | 72,799 | Jan 30, 2015, 04:14 PM |
| MARSH GUY P | VP, US Operations & GM | Jan 29, 2015 | Sale | $2.78 | 238 | 662 | 31,487 | Jan 30, 2015, 04:14 PM |
| Sanford Svai S | CFO & Chief Accounting Officer | Jan 29, 2015 | Sale | $2.78 | 472 | 1,312 | 65,559 | Jan 30, 2015, 04:14 PM |
| NORTH TIDE CAPITAL, LLC | 10% Owner | Jan 07, 2015 | Buy | $3.05 | 218,820 | 666,697 | 12,282,100 | Jan 09, 2015, 04:37 PM |
| NORTH TIDE CAPITAL, LLC | 10% Owner | Jan 08, 2015 | Buy | $3.22 | 217,900 | 701,640 | 12,500,000 | Jan 09, 2015, 04:37 PM |
| NORTH TIDE CAPITAL, LLC | 10% Owner | Jan 07, 2015 | Buy | $3.05 | 63,280 | 193,004 | 12,157,100 | Jan 09, 2015, 04:37 PM |
| NORTH TIDE CAPITAL, LLC | 10% Owner | Jan 06, 2015 | Buy | $3.03 | 147,936 | 448,798 | 12,000,000 | Jan 07, 2015, 04:14 PM |
| NORTH TIDE CAPITAL, LLC | 10% Owner | Jan 05, 2015 | Buy | $3.05 | 328,864 | 1,002,372 | 11,852,064 | Jan 07, 2015, 04:14 PM |
| NORTH TIDE CAPITAL, LLC | 10% Owner | Jan 02, 2015 | Buy | $2.99 | 218,400 | 652,845 | 11,523,200 | Jan 05, 2015, 04:21 PM |
| NORTH TIDE CAPITAL, LLC | 10% Owner | Dec 31, 2014 | Buy | $2.83 | 304,800 | 862,680 | 11,304,800 | Jan 05, 2015, 04:21 PM |
| MARSH GUY P | VP, Operations and General Mgr | Jul 02, 2014 | Option Exercise | $5.31 | 554 | 2,942 | 19,669 | Jul 07, 2014, 04:51 PM |
| Slebir John L | SVP & General Counsel | Jul 02, 2014 | Option Exercise | $5.31 | 2,661 | 14,130 | 47,528 | Jul 07, 2014, 04:51 PM |
| Day Wesley | VP, Clinical Development | Jul 02, 2014 | Option Exercise | $5.31 | 2,281 | 12,112 | 32,971 | Jul 07, 2014, 04:50 PM |
| Fischer Seth H.Z. | Chief Executive Officer | Mar 11, 2014 | Buy | $6.07 | 3,080 | 18,695 | 3,080 | Mar 12, 2014, 06:37 PM |
| DENNER ALEXANDER J | Director | Nov 11, 2013 | Buy | $8.78 | 149,776 | 1,315,033 | 2,573,943 | Nov 12, 2013, 05:08 PM |
| DENNER ALEXANDER J | Director | Nov 08, 2013 | Buy | $8.52 | 417,068 | 3,553,420 | 2,424,167 | Nov 12, 2013, 05:08 PM |
| MORRIS TIMOTHY E | VP, Finance and CFO | Sep 05, 2013 | Option Exercise | $4.23 | 10,654 | 45,066 | 10,654 | Sep 09, 2013, 07:29 PM |
| MORRIS TIMOTHY E | VP, Finance and CFO | Sep 05, 2013 | Sale | $11.95 | 10,654 | 127,283 | 0 | Sep 09, 2013, 07:29 PM |
| ASTRUE MICHAEL J | Director | Sep 04, 2013 | Buy | $11.96 | 10,000 | 119,597 | 10,000 | Sep 06, 2013, 04:09 PM |
| BIRO JON C | 10% Owner | Jun 27, 2013 | Buy | $12.85 | 2,000 | 25,699 | 4,000 | Jul 01, 2013, 06:21 PM |
| MARIO ERNEST | Director | May 29, 2013 | Buy | $14.68 | 15,000 | 220,206 | 81,125 | May 30, 2013, 01:54 PM |
| MARIO ERNEST | Director | Aug 20, 2012 | Buy | $20.75 | 5,000 | 103,750 | 45,000 | Aug 21, 2012, 07:03 PM |
| CASAMENTO CHARLES J | Director | Aug 20, 2012 | Option Exercise | $5.69 | 8,000 | 45,520 | 74,000 | Aug 21, 2012, 07:00 PM |
| CASAMENTO CHARLES J | Director | Aug 20, 2012 | Sale | $20.63 | 8,000 | 165,060 | 66,000 | Aug 21, 2012, 07:00 PM |
| LOGAN MARK B | Director | Aug 14, 2012 | Option Exercise | $5.64 | 49,816 | 280,838 | 75,000 | Aug 15, 2012, 07:54 PM |
| LOGAN MARK B | Director | Aug 14, 2012 | Sale | $23.13 | 49,816 | 1,152,169 | 53,000 | Aug 15, 2012, 07:54 PM |
| SHORTLIFFE LINDA M DAIRIKI | Director | Aug 14, 2012 | Option Exercise | $4.60 | 18,000 | 82,820 | 15,000 | Aug 15, 2012, 07:53 PM |
| SHORTLIFFE LINDA M DAIRIKI | Director | Aug 14, 2012 | Sale | $22.72 | 18,000 | 409,000 | 5,000 | Aug 15, 2012, 07:53 PM |
| LOGAN MARK B | Director | Aug 13, 2012 | Option Exercise | $4.25 | 18,184 | 77,282 | 71,184 | Aug 14, 2012, 06:52 PM |
| LOGAN MARK B | Director | Aug 13, 2012 | Sale | $21.81 | 18,184 | 396,580 | 53,000 | Aug 14, 2012, 06:52 PM |
| SHORTLIFFE LINDA M DAIRIKI | Director | Aug 10, 2012 | Option Exercise | $4.23 | 25,000 | 105,750 | 30,000 | Aug 14, 2012, 06:47 PM |
| SHORTLIFFE LINDA M DAIRIKI | Director | Aug 13, 2012 | Option Exercise | $4.25 | 20,000 | 85,000 | 25,000 | Aug 14, 2012, 06:47 PM |
| SHORTLIFFE LINDA M DAIRIKI | Director | Aug 13, 2012 | Sale | $22.00 | 20,000 | 440,000 | 5,000 | Aug 14, 2012, 06:47 PM |
| SHORTLIFFE LINDA M DAIRIKI | Director | Aug 10, 2012 | Sale | $21.50 | 25,000 | 537,500 | 5,000 | Aug 14, 2012, 06:47 PM |
| MARIO ERNEST | Director | Aug 10, 2012 | Buy | $21.50 | 5,000 | 107,500 | 40,000 | Aug 13, 2012, 06:00 PM |
| MARIO ERNEST | Director | Aug 09, 2012 | Buy | $21.83 | 15,000 | 327,399 | 35,000 | Aug 13, 2012, 06:00 PM |
| Slebir John L | VP, General Counsel | Jul 18, 2012 | Option Exercise | $7.27 | 10,000 | 72,712 | 10,376 | Jul 20, 2012, 07:21 PM |
| Slebir John L | VP, General Counsel | Jul 18, 2012 | Sale | $30.36 | 10,000 | 303,600 | 4,126 | Jul 20, 2012, 07:21 PM |
| TAM PETER Y | President | Jul 18, 2012 | Option Exercise | $4.25 | 25,000 | 106,250 | 62,629 | Jul 20, 2012, 07:17 PM |
| TAM PETER Y | President | Jul 18, 2012 | Sale | $30.95 | 25,000 | 773,750 | 37,629 | Jul 20, 2012, 07:17 PM |
| Day Wesley | VP, Clinical Research | Jul 18, 2012 | Sale | $30.36 | 16,800 | 510,048 | 0 | Jul 20, 2012, 07:15 PM |
| MORRIS TIMOTHY E | VP, Finance and CFO | Jul 18, 2012 | Option Exercise | $4.23 | 25,000 | 105,750 | 25,000 | Jul 20, 2012, 07:14 PM |
| MORRIS TIMOTHY E | VP, Finance and CFO | Jul 18, 2012 | Sale | $30.36 | 25,000 | 759,000 | 0 | Jul 20, 2012, 07:14 PM |
| WILSON LELAND F | CEO | Jul 18, 2012 | Option Exercise | $3.34 | 100,000 | 333,754 | 169,427 | Jul 20, 2012, 07:12 PM |
| WILSON LELAND F | CEO | Jul 18, 2012 | Sale | $30.36 | 100,000 | 3,036,000 | 119,112 | Jul 20, 2012, 07:12 PM |
| MARSH GUY P | VP, Operations and General Mgr | Jul 18, 2012 | Option Exercise | $4.69 | 36,191 | 169,664 | 25,713 | Jul 20, 2012, 07:10 PM |
| MARSH GUY P | VP, Operations and General Mgr | Jul 18, 2012 | Sale | $30.36 | 36,191 | 1,098,759 | 2,074 | Jul 20, 2012, 07:10 PM |
| MILLER MICHAEL PATRICK | Chief Commercial Officer | Jul 18, 2012 | Option Exercise | $10.19 | 25,000 | 254,750 | 32,943 | Jul 20, 2012, 07:07 PM |
| MILLER MICHAEL PATRICK | Chief Commercial Officer | Jul 18, 2012 | Sale | $30.36 | 25,000 | 759,000 | 7,943 | Jul 20, 2012, 07:07 PM |
| WILSON LELAND F | CEO | Jun 27, 2012 | Option Exercise | $4.15 | 50,000 | 207,500 | 169,112 | Jul 02, 2012, 09:49 PM |
| WILSON LELAND F | CEO | Jun 27, 2012 | Sale | $28.00 | 50,000 | 1,400,000 | 119,112 | Jul 02, 2012, 09:49 PM |
| MILLER MICHAEL PATRICK | Chief Commercial Officer | Jun 27, 2012 | Option Exercise | $10.19 | 25,000 | 254,750 | 32,943 | Jun 29, 2012, 05:01 PM |
| MILLER MICHAEL PATRICK | Chief Commercial Officer | Jun 27, 2012 | Sale | $28.08 | 25,000 | 701,900 | 7,943 | Jun 29, 2012, 05:01 PM |
| TAM PETER Y | President | Jun 19, 2012 | Option Exercise | $3.73 | 20,000 | 74,600 | 57,629 | Jun 20, 2012, 07:29 PM |
| TAM PETER Y | President | Jun 19, 2012 | Sale | $27.25 | 20,000 | 545,000 | 37,629 | Jun 20, 2012, 07:29 PM |
| TAM PETER Y | President | Jun 18, 2012 | Option Exercise | $3.73 | 20,000 | 74,600 | 57,629 | Jun 19, 2012, 06:42 PM |
| TAM PETER Y | President | Jun 18, 2012 | Sale | $26.45 | 20,000 | 529,000 | 37,629 | Jun 19, 2012, 06:42 PM |
| TAM PETER Y | President | Jun 14, 2012 | Sale | $25.25 | 60,000 | 1,515,000 | 37,629 | Jun 18, 2012, 09:25 PM |
| TAM PETER Y | President | Jun 14, 2012 | Option Exercise | $3.95 | 236,250 | 932,550 | 123,149 | Jun 18, 2012, 09:24 PM |
| TAM PETER Y | President | Jun 14, 2012 | Sale | $25.28 | 236,250 | 5,973,534 | 97,629 | Jun 18, 2012, 09:24 PM |
| MILLER MICHAEL PATRICK | Chief Commercial Officer | Jun 12, 2012 | Option Exercise | $10.19 | 25,000 | 254,750 | 32,943 | Jun 14, 2012, 05:11 PM |
| MILLER MICHAEL PATRICK | Chief Commercial Officer | Jun 12, 2012 | Sale | $25.00 | 25,000 | 625,000 | 7,943 | Jun 14, 2012, 05:11 PM |
| WILSON LELAND F | CEO | Jun 11, 2012 | Option Exercise | $4.15 | 50,000 | 207,500 | 145,232 | Jun 13, 2012, 01:11 PM |
| WILSON LELAND F | CEO | Jun 11, 2012 | Sale | $25.18 | 50,000 | 1,259,000 | 119,112 | Jun 13, 2012, 01:11 PM |
| LOGAN MARK B | Director | Mar 16, 2012 | Option Exercise | $3.61 | 14,000 | 50,540 | 56,000 | Mar 20, 2012, 02:44 PM |
| LOGAN MARK B | Director | Mar 16, 2012 | Sale | $20.32 | 14,000 | 284,453 | 48,000 | Mar 20, 2012, 02:44 PM |
| MARSH GUY P | VP, Operations & General Mgr. | Mar 15, 2012 | Sale | $20.31 | 6,605 | 134,148 | 1,106 | Mar 19, 2012, 06:28 PM |
| CASAMENTO CHARLES J | Director | Mar 12, 2012 | Option Exercise | $8.88 | 37,000 | 328,460 | 86,000 | Mar 13, 2012, 04:48 PM |
| CASAMENTO CHARLES J | Director | Mar 12, 2012 | Sale | $20.14 | 37,000 | 745,217 | 61,000 | Mar 13, 2012, 04:48 PM |
| SHORTLIFFE LINDA M DAIRIKI | Director | Mar 08, 2012 | Option Exercise | $4.37 | 52,000 | 227,100 | 8,000 | Mar 12, 2012, 05:24 PM |
| SHORTLIFFE LINDA M DAIRIKI | Director | Mar 08, 2012 | Sale | $21.50 | 52,000 | 1,118,000 | 0 | Mar 12, 2012, 05:24 PM |
| Perry Lee | VP & Chief Accounting Officer | Mar 09, 2012 | Option Exercise | $6.40 | 87,623 | 561,142 | 27,848 | Mar 12, 2012, 05:24 PM |
| Perry Lee | VP & Chief Accounting Officer | Mar 09, 2012 | Sale | $20.96 | 87,623 | 1,836,210 | 0 | Mar 12, 2012, 05:24 PM |
| CASAMENTO CHARLES J | Director | Feb 27, 2012 | Option Exercise | $6.00 | 36,000 | 216,040 | 61,000 | Feb 28, 2012, 04:18 PM |
| WILSON LELAND F | CEO | Feb 27, 2012 | Option Exercise | $4.31 | 50,000 | 215,732 | 141,146 | Feb 28, 2012, 02:53 PM |
| WILSON LELAND F | CEO | Feb 27, 2012 | Sale | $25.00 | 50,000 | 1,250,000 | 118,271 | Feb 28, 2012, 02:53 PM |
| MARSH GUY P | VP, Operations and General Mgr | Feb 27, 2012 | Option Exercise | $6.96 | 47,078 | 327,722 | 39,789 | Feb 28, 2012, 02:53 PM |
| MARSH GUY P | VP, Operations and General Mgr | Feb 27, 2012 | Sale | $22.93 | 47,078 | 1,079,499 | 7,711 | Feb 28, 2012, 02:53 PM |
| MORRIS TIMOTHY E | SVP, Finance and CFO | Feb 24, 2012 | Option Exercise | $5.67 | 25,000 | 141,750 | 25,000 | Feb 27, 2012, 09:51 PM |
| MORRIS TIMOTHY E | SVP, Finance and CFO | Feb 23, 2012 | Option Exercise | $5.09 | 254,358 | 1,293,586 | 125,000 | Feb 27, 2012, 09:51 PM |
| MORRIS TIMOTHY E | SVP, Finance and CFO | Feb 27, 2012 | Option Exercise | $4.95 | 50,000 | 247,500 | 25,000 | Feb 27, 2012, 09:51 PM |
| MORRIS TIMOTHY E | SVP, Finance and CFO | Feb 23, 2012 | Sale | $20.71 | 254,358 | 5,267,917 | 0 | Feb 27, 2012, 09:51 PM |
| MORRIS TIMOTHY E | SVP, Finance and CFO | Feb 27, 2012 | Sale | $23.91 | 50,000 | 1,195,750 | 0 | Feb 27, 2012, 09:51 PM |
| MORRIS TIMOTHY E | SVP, Finance and CFO | Feb 24, 2012 | Sale | $21.55 | 25,000 | 538,750 | 0 | Feb 27, 2012, 09:51 PM |
| WILSON LELAND F | Chief Executive Officer | Feb 23, 2012 | Option Exercise | $4.28 | 150,000 | 642,267 | 195,396 | Feb 24, 2012, 08:38 PM |
| WILSON LELAND F | Chief Executive Officer | Feb 23, 2012 | Sale | $20.69 | 150,000 | 3,103,500 | 118,271 | Feb 24, 2012, 08:38 PM |
| MARSH GUY P | VP, Operations & General Mgr. | Feb 23, 2012 | Option Exercise | $4.24 | 86,777 | 367,611 | 57,710 | Feb 24, 2012, 08:36 PM |
| MARSH GUY P | VP, Operations & General Mgr. | Feb 23, 2012 | Sale | $20.70 | 86,777 | 1,796,284 | 7,711 | Feb 24, 2012, 08:36 PM |
| Day Wesley | VP, Clinical Development | Feb 23, 2012 | Option Exercise | $4.13 | 79,958 | 330,162 | 67,062 | Feb 24, 2012, 08:33 PM |
| Day Wesley | VP, Clinical Development | Feb 23, 2012 | Sale | $20.69 | 79,958 | 1,654,331 | 16,800 | Feb 24, 2012, 08:33 PM |
| Perry Lee | VP & Chief Accounting Officer | Feb 23, 2012 | Option Exercise | $4.69 | 171,832 | 805,876 | 40,000 | Feb 24, 2012, 08:30 PM |
| Perry Lee | VP & Chief Accounting Officer | Feb 23, 2012 | Sale | $20.69 | 171,832 | 3,555,204 | 0 | Feb 24, 2012, 08:30 PM |
| TAM PETER Y | President | Jan 11, 2012 | Sale | $12.00 | 27,014 | 324,168 | 96,221 | Jan 13, 2012, 11:33 AM |
| TAM PETER Y | President | Jan 10, 2012 | Sale | $12.00 | 12,386 | 148,632 | 123,235 | Jan 11, 2012, 05:12 PM |
| Perry Lee | VP & Chief Accounting Officer | Jan 09, 2012 | Option Exercise | $3.02 | 39,700 | 119,761 | 25,000 | Jan 11, 2012, 02:37 PM |
| Perry Lee | VP & Chief Accounting Officer | Jan 09, 2012 | Sale | $11.75 | 39,700 | 466,475 | 0 | Jan 11, 2012, 02:37 PM |
| Day Wesley | VP, Clinical Development | Jan 09, 2012 | Option Exercise | $3.28 | 30,000 | 98,400 | 46,800 | Jan 11, 2012, 02:34 PM |
| Day Wesley | VP, Clinical Development | Jan 09, 2012 | Sale | $11.50 | 30,000 | 345,000 | 16,800 | Jan 11, 2012, 02:34 PM |
| CASAMENTO CHARLES J | Director | Dec 06, 2011 | Option Exercise | $4.23 | 25,000 | 105,750 | 25,000 | Dec 08, 2011, 03:13 PM |
| Day Wesley | VP, Clinical Development | Nov 11, 2011 | Option Exercise | $3.26 | 23,442 | 76,380 | 40,242 | Nov 15, 2011, 07:26 PM |
| Day Wesley | VP, Clinical Development | Nov 11, 2011 | Sale | $9.87 | 23,442 | 231,349 | 16,800 | Nov 15, 2011, 07:26 PM |
| TAM PETER Y | President | Jul 11, 2011 | Option Exercise | $3.40 | 5,000 | 17,000 | 135,621 | Jul 12, 2011, 06:43 PM |
| Day Wesley | VP, Clinical Development | Dec 17, 2010 | Sale | $9.54 | 70,600 | 673,446 | 16,800 | Jan 07, 2011, 06:22 PM |
| TAM PETER Y | President | Dec 16, 2010 | Option Exercise | $3.88 | 18,750 | 72,656 | 136,775 | Dec 20, 2010, 05:37 PM |
| TAM PETER Y | President | Dec 16, 2010 | Sale | $9.28 | 10,000 | 92,807 | 126,775 | Dec 20, 2010, 05:37 PM |
| LOGAN MARK B | Director | Dec 15, 2010 | Option Exercise | $5.73 | 18,000 | 103,180 | 66,000 | Dec 17, 2010, 09:49 PM |
| LOGAN MARK B | Director | Dec 17, 2010 | Option Exercise | $3.67 | 20,000 | 73,380 | 68,000 | Dec 17, 2010, 09:49 PM |
| LOGAN MARK B | Director | Dec 15, 2010 | Sale | $9.14 | 18,000 | 164,520 | 48,000 | Dec 17, 2010, 09:49 PM |
| LOGAN MARK B | Director | Dec 17, 2010 | Sale | $9.52 | 20,000 | 190,338 | 48,000 | Dec 17, 2010, 09:49 PM |
| SHORTLIFFE LINDA M DAIRIKI | Director | Dec 15, 2010 | Option Exercise | $3.96 | 8,000 | 31,680 | 8,000 | Dec 17, 2010, 09:39 PM |
| SHORTLIFFE LINDA M DAIRIKI | Director | Dec 15, 2010 | Sale | $9.31 | 8,000 | 74,480 | 0 | Dec 17, 2010, 09:39 PM |
| Day Wesley | VP, Clinical Development | Dec 17, 2010 | Option Exercise | $3.26 | 60,000 | 195,600 | 87,400 | Dec 17, 2010, 09:37 PM |
| Day Wesley | VP, Clinical Development | Dec 17, 2010 | Sale | $9.54 | 66,600 | 635,491 | 20,800 | Dec 17, 2010, 09:37 PM |
| WILSON LELAND F | Chief Executive Officer | Dec 15, 2010 | Option Exercise | $3.88 | 100,000 | 387,500 | 177,966 | Dec 17, 2010, 09:35 PM |
| WILSON LELAND F | Chief Executive Officer | Dec 15, 2010 | Sale | $9.16 | 62,000 | 568,156 | 115,966 | Dec 17, 2010, 09:35 PM |
| LOGAN MARK B | Director | Jul 22, 2010 | Option Exercise | $3.96 | 8,000 | 31,680 | 48,000 | Jul 26, 2010, 07:19 PM |
Load More Insider Transactions
Buy
Sale
Option Exercise
| Owner | Relationship | Date | Value($) |
| Oki Mark K | SVP, CFO, CAO | 11/14/2019 | 1,666 |
| Varghese Santosh T | Chief Medical Officer | 11/14/2019 | 1,666 |
| Oki Mark K | SVP, CFO, CAO | 05/14/2019 | 1,988 |
| Varghese Santosh T | Chief Medical Officer | 05/14/2019 | 1,988 |
| Amos John P. | Chief Executive Officer | 03/01/2019 | 53,384 |
| Roberts Eric W | Director | 02/28/2019 | 40,982 |
| Amos John P. | Chief Executive Officer | 03/01/2019 | 53,384 |
| Varghese Santosh T | Chief Medical Officer | 11/14/2018 | 1,897 |
| Oki Mark K | Chief Financial Officer & CAO | 11/14/2018 | 1,897 |
| Oki Mark K | Chief Financial Officer & CAO | 11/06/2018 | 40,700 |
| Shaw Allan | Director | 10/01/2018 | 242 |
| Roberts Eric W | Director | 10/01/2018 | 242 |
| Shaw Allan | Director | 08/15/2018 | 276 |
| Roberts Eric W | Director | 08/15/2018 | 276 |
| Roberts Eric W | Director | 07/15/2018 | 338 |
| Shaw Allan | Director | 07/15/2018 | 338 |
| ROSENMAN HERM | Director | 06/29/2018 | 17,500 |
| Shaw Allan | Director | 06/15/2018 | 368 |
| Roberts Eric W | Director | 06/15/2018 | 368 |
| ROSENMAN HERM | Director | 06/01/2018 | 38,500 |
| ROSENMAN HERM | Director | 05/29/2018 | 39,500 |
| ROSENMAN HERM | Director | 05/21/2018 | 52,500 |
| ROSENMAN HERM | Director | 05/21/2018 | 81,000 |
| Amos John P. | Chief Executive Officer | 05/18/2018 | 208,089 |
| Amos John P. | Chief Executive Officer | 05/18/2018 | 1,156 |
| Amos John P. | Chief Executive Officer | 05/17/2018 | 249,228 |
| Shaw Allan | Director | 05/15/2018 | 228 |
| Roberts Eric W | Director | 05/15/2018 | 258 |
| Amos John P. | Chief Executive Officer | 05/16/2018 | 156,546 |
| Amos John P. | Chief Executive Officer | 05/15/2018 | 146,529 |
| Amos John P. | Chief Executive Officer | 05/14/2018 | 138,672 |
| Amos John P. | Chief Executive Officer | 05/11/2018 | 139,914 |
| Shaw Allan | Director | 04/15/2018 | 184 |
| Roberts Eric W | Director | 04/15/2018 | 184 |
| Varghese Santosh T | Chief Medical Officer | 04/03/2018 | 132 |
| Slebir John L | SVP, Business Development & GC | 04/01/2018 | 199 |
| Shaw Allan | Director | 03/15/2018 | 210 |
| Roberts Eric W | Director | 03/15/2018 | 210 |
| Shaw Allan | Director | 02/15/2018 | 201 |
| Roberts Eric W | Director | 02/15/2018 | 229 |
| Varghese Santosh T | Chief Medical Officer | 01/31/2018 | 211 |
| Slebir John L | SVP, Business Development & GC | 01/28/2018 | 282 |
| Shaw Allan | Director | 01/15/2018 | 245 |
| Roberts Eric W | Director | 01/15/2018 | 275 |
| Fischer Seth H. Z. | Consultant | 01/01/2018 | 1,051 |
| Varghese Santosh T | Chief Medical Officer | 01/01/2018 | 226 |
| Slebir John L | SVP, Business Development & GC | 01/01/2018 | 355 |
| Shaw Allan | Director | 12/15/2017 | 255 |
| Roberts Eric W | Director | 12/15/2017 | 286 |
| Shaw Allan | Director | 11/15/2017 | 315 |
| Roberts Eric W | Director | 11/15/2017 | 354 |
| Shaw Allan | Director | 10/27/2017 | 3,029 |
| ROSENMAN HERM | Director | 10/27/2017 | 3,082 |
| Roberts Eric W | Director | 10/27/2017 | 3,401 |
| Plutzky Jorge MD | Director | 10/27/2017 | 2,633 |
| Norton David Y | Director | 10/27/2017 | 2,187 |
| Roberts Eric W | Director | 10/16/2017 | 464 |
| Shaw Allan | Director | 10/16/2017 | 413 |
| Varghese Santosh T | Chief Medical Officer | 10/03/2017 | 421 |
| Shaw Allan | Director | 09/15/2017 | 481 |
| Roberts Eric W | Director | 09/15/2017 | 540 |
| Shaw Allan | Director | 08/15/2017 | 485 |
| Roberts Eric W | Director | 08/15/2017 | 544 |
| Shaw Allan | Director | 08/08/2017 | 4,370 |
| ROSENMAN HERM | Director | 08/08/2017 | 4,447 |
| Roberts Eric W | Director | 08/08/2017 | 4,908 |
| Plutzky Jorge MD | Director | 08/08/2017 | 3,800 |
| Norton David Y | Director | 08/08/2017 | 3,156 |
| Roberts Eric W | Director | 07/15/2017 | 686 |
| Shaw Allan | Director | 07/15/2017 | 611 |
| Varghese Santosh T | Chief Medical Officer | 07/03/2017 | 520 |
| Shaw Allan | Director | 06/15/2017 | 5,624 |
| ROSENMAN HERM | Director | 06/15/2017 | 5,152 |
| Roberts Eric W | Director | 06/15/2017 | 6,316 |
| Plutzky Jorge MD | Director | 06/15/2017 | 4,402 |
| Norton David Y | Director | 06/15/2017 | 3,656 |
| Shaw Allan | Director | 04/15/2017 | 495 |
| Roberts Eric W | Director | 04/15/2017 | 556 |
| Varghese Santosh T | Chief Medical Officer | 04/04/2017 | 475 |
| Roberts Eric W | Director | 03/15/2017 | 598 |
| Shaw Allan | Director | 03/15/2017 | 533 |
| NORTH TIDE CAPITAL, LLC | 10% Owner | 03/10/2017 | 90,244 |
| NORTH TIDE CAPITAL, LLC | 10% Owner | 03/09/2017 | 873,249 |
| NORTH TIDE CAPITAL, LLC | 10% Owner | 03/08/2017 | 368,340 |
| NORTH TIDE CAPITAL, LLC | 10% Owner | 03/03/2017 | 36,363 |
| NORTH TIDE CAPITAL, LLC | 10% Owner | 03/07/2017 | 156,151 |
| NORTH TIDE CAPITAL, LLC | 10% Owner | 03/06/2017 | 16,230 |
| NORTH TIDE CAPITAL, LLC | 10% Owner | 03/02/2017 | 22,500 |
| NORTH TIDE CAPITAL, LLC | 10% Owner | 03/01/2017 | 130,046 |
| NORTH TIDE CAPITAL, LLC | 10% Owner | 02/28/2017 | 28,593 |
| NORTH TIDE CAPITAL, LLC | 10% Owner | 02/27/2017 | 168,965 |
| NORTH TIDE CAPITAL, LLC | 10% Owner | 02/24/2017 | 37,505 |
| NORTH TIDE CAPITAL, LLC | 10% Owner | 02/23/2017 | 174,015 |
| NORTH TIDE CAPITAL, LLC | 10% Owner | 02/22/2017 | 121,582 |
| NORTH TIDE CAPITAL, LLC | 10% Owner | 02/21/2017 | 57,610 |
| NORTH TIDE CAPITAL, LLC | 10% Owner | 02/17/2017 | 334 |
| Shaw Allan | Director | 02/15/2017 | 528 |
| Roberts Eric W | Director | 02/15/2017 | 593 |
| NORTH TIDE CAPITAL, LLC | 10% Owner | 02/15/2017 | 44,500 |
| NORTH TIDE CAPITAL, LLC | 10% Owner | 02/14/2017 | 126,500 |
| NORTH TIDE CAPITAL, LLC | 10% Owner | 02/16/2017 | 165,250 |
| NORTH TIDE CAPITAL, LLC | 10% Owner | 02/13/2017 | 74,022 |
| NORTH TIDE CAPITAL, LLC | 10% Owner | 02/10/2017 | 50,839 |
| NORTH TIDE CAPITAL, LLC | 10% Owner | 02/09/2017 | 70,421 |
| Plutzky Jorge MD | Director | 02/08/2017 | 4,063 |
| Roberts Eric W | Director | 02/08/2017 | 5,248 |
| ROSENMAN HERM | Director | 02/08/2017 | 4,755 |
| Shaw Allan | Director | 02/08/2017 | 4,673 |
| Norton David Y | Director | 02/08/2017 | 3,375 |
| NORTH TIDE CAPITAL, LLC | 10% Owner | 02/08/2017 | 561,742 |
| NORTH TIDE CAPITAL, LLC | 10% Owner | 02/07/2017 | 6,861 |
| NORTH TIDE CAPITAL, LLC | 10% Owner | 02/06/2017 | 30,942 |
| NORTH TIDE CAPITAL, LLC | 10% Owner | 02/02/2017 | 3,616 |
| NORTH TIDE CAPITAL, LLC | 10% Owner | 02/01/2017 | 24,941 |
| NORTH TIDE CAPITAL, LLC | 10% Owner | 02/03/2017 | 59,690 |
| Varghese Santosh T | Chief Medical Officer | 01/28/2017 | 476 |
| Roberts Eric W | Director | 01/15/2017 | 647 |
| Shaw Allan | Director | 01/15/2017 | 647 |
| Sris Mayu | Resigned as Director 1/16/2017 | 01/15/2017 | 416 |
| Sris Mayu | Resigned as Director 1/16/2017 | 01/16/2017 | 2,500 |
| Varghese Santosh T | Chief Medical Officer | 12/31/2016 | 15,478 |
| Shaw Allan | Director | 12/15/2016 | 744 |
| Sris Mayu | Director | 12/15/2016 | 479 |
| Roberts Eric W | Director | 12/15/2016 | 744 |
| Sris Mayu | Director | 11/15/2016 | 382 |
| Shaw Allan | Director | 11/15/2016 | 593 |
| Roberts Eric W | Director | 11/15/2016 | 593 |
| Plutzky Jorge MD | Director | 10/31/2016 | 987 |
| ROSENMAN HERM | Director | 10/31/2016 | 1,155 |
| Norton David Y | Director | 10/31/2016 | 820 |
| Sris Mayu | Director | 10/15/2016 | 368 |
| Roberts Eric W | Director | 10/15/2016 | 572 |
| Shaw Allan | Director | 10/15/2016 | 572 |
| Varghese Santosh T | Chief Medical Officer | 10/01/2016 | 809 |
| Plutzky Jorge MD | Director | 09/30/2016 | 1,072 |
| ROSENMAN HERM | Director | 09/30/2016 | 1,254 |
| Norton David Y | Director | 09/30/2016 | 890 |
| Shaw Allan | Director | 09/15/2016 | 572 |
| Roberts Eric W | Director | 09/15/2016 | 572 |
| Sris Mayu | Director | 09/15/2016 | 368 |
| Plutzky Jorge MD | Director | 08/31/2016 | 1,006 |
| ROSENMAN HERM | Director | 08/31/2016 | 1,178 |
| Norton David Y | Director | 08/31/2016 | 835 |
| Roberts Eric W | Director | 08/15/2016 | 589 |
| Shaw Allan | Director | 08/15/2016 | 589 |
| Sris Mayu | Director | 08/15/2016 | 378 |
| Varghese Santosh T | Chief Medical Officer | 08/02/2016 | 13,438 |
| ROSENMAN HERM | Director | 07/31/2016 | 1,177 |
| Plutzky Jorge MD | Director | 07/31/2016 | 1,006 |
| Norton David Y | Director | 07/31/2016 | 836 |
| Sris Mayu | Director | 07/15/2016 | 399 |
| Shaw Allan | Director | 07/15/2016 | 621 |
| Roberts Eric W | Director | 07/15/2016 | 621 |
| Varghese Santosh T | VP, Medical & Reg Affairs | 07/01/2016 | 443 |
| ROSENMAN HERM | Director | 06/30/2016 | 1,232 |
| Plutzky Jorge MD | Director | 06/30/2016 | 1,053 |
| Norton David Y | Director | 06/30/2016 | 875 |
| Sris Mayu | Director | 06/15/2016 | 413 |
| ROSENMAN HERM | Director | 05/30/2016 | 9,478 |
| Plutzky Jorge MD | Director | 05/30/2016 | 8,098 |
| Norton David Y | Director | 05/30/2016 | 6,726 |
| Sris Mayu | Director | 05/15/2016 | 3,221 |
| Shaw Allan | Director | 05/15/2016 | 5,009 |
| Roberts Eric W | Director | 05/15/2016 | 5,009 |
| Slebir John L | SVP, Business Development & GC | 07/01/2015 | 21,861 |
| Slebir John L | SVP, Business Development & GC | 01/01/2015 | 9,038 |
| MARSH GUY P | VP, US Operations & GM | 01/29/2015 | 1,924 |
| Day Wesley | VP, Clinical Development | 01/01/2015 | 7,749 |
| Varghese Santosh T | Chief Medical Officer | 04/07/2016 | 543 |
| Varghese Santosh T | Chief Medical Officer | 01/13/2016 | 1,475 |
| Varghese Santosh T | VP, Medical & Reg Affairs | 07/01/2015 | 18,738 |
| NORTH TIDE CAPITAL, LLC | 10% Owner | 04/01/2016 | 3,028 |
| NORTH TIDE CAPITAL, LLC | 10% Owner | 03/31/2016 | 234,225 |
| NORTH TIDE CAPITAL, LLC | 10% Owner | 03/30/2016 | 125,450 |
| NORTH TIDE CAPITAL, LLC | 10% Owner | 03/29/2016 | 133,843 |
| NORTH TIDE CAPITAL, LLC | 10% Owner | 03/24/2016 | 27,242 |
| NORTH TIDE CAPITAL, LLC | 10% Owner | 03/28/2016 | 199,390 |
| NORTH TIDE CAPITAL, LLC | 10% Owner | 03/16/2016 | 180,687 |
| NORTH TIDE CAPITAL, LLC | 10% Owner | 03/15/2016 | 303,507 |
| NORTH TIDE CAPITAL, LLC | 10% Owner | 03/14/2016 | 119,499 |
| Varghese Santosh T | VP, Medical & Reg Affairs | 07/01/2015 | 18,326 |
| Slebir John L | SVP, Business Development & GC | 07/01/2015 | 21,379 |
| Day Wesley | VP, Clinical Development | 07/01/2015 | 18,284 |
| Day Wesley | VP, Clinical Development | 01/29/2015 | 1,312 |
| Slebir John L | SVP, Business Development & GC | 01/29/2015 | 1,751 |
| MARSH GUY P | VP, US Operations & GM | 01/29/2015 | 662 |
| Sanford Svai S | CFO & Chief Accounting Officer | 01/29/2015 | 1,312 |
| NORTH TIDE CAPITAL, LLC | 10% Owner | 01/07/2015 | 666,697 |
| NORTH TIDE CAPITAL, LLC | 10% Owner | 01/08/2015 | 701,640 |
| NORTH TIDE CAPITAL, LLC | 10% Owner | 01/07/2015 | 193,004 |
| NORTH TIDE CAPITAL, LLC | 10% Owner | 01/06/2015 | 448,798 |
| NORTH TIDE CAPITAL, LLC | 10% Owner | 01/05/2015 | 1,002,372 |
| NORTH TIDE CAPITAL, LLC | 10% Owner | 01/02/2015 | 652,845 |
| NORTH TIDE CAPITAL, LLC | 10% Owner | 12/31/2014 | 862,680 |
| MARSH GUY P | VP, Operations and General Mgr | 07/02/2014 | 2,942 |
| Slebir John L | SVP & General Counsel | 07/02/2014 | 14,130 |
| Day Wesley | VP, Clinical Development | 07/02/2014 | 12,112 |
| Fischer Seth H.Z. | Chief Executive Officer | 03/11/2014 | 18,695 |
| DENNER ALEXANDER J | Director | 11/11/2013 | 1,315,033 |
| DENNER ALEXANDER J | Director | 11/08/2013 | 3,553,420 |
| MORRIS TIMOTHY E | VP, Finance and CFO | 09/05/2013 | 45,066 |
| MORRIS TIMOTHY E | VP, Finance and CFO | 09/05/2013 | 127,283 |
| ASTRUE MICHAEL J | Director | 09/04/2013 | 119,597 |
| BIRO JON C | 10% Owner | 06/27/2013 | 25,699 |
| MARIO ERNEST | Director | 05/29/2013 | 220,206 |
| MARIO ERNEST | Director | 08/20/2012 | 103,750 |
| CASAMENTO CHARLES J | Director | 08/20/2012 | 45,520 |
| CASAMENTO CHARLES J | Director | 08/20/2012 | 165,060 |
| LOGAN MARK B | Director | 08/14/2012 | 280,838 |
| LOGAN MARK B | Director | 08/14/2012 | 1,152,169 |
| SHORTLIFFE LINDA M DAIRIKI | Director | 08/14/2012 | 82,820 |
| SHORTLIFFE LINDA M DAIRIKI | Director | 08/14/2012 | 409,000 |
| LOGAN MARK B | Director | 08/13/2012 | 77,282 |
| LOGAN MARK B | Director | 08/13/2012 | 396,580 |
| SHORTLIFFE LINDA M DAIRIKI | Director | 08/10/2012 | 105,750 |
| SHORTLIFFE LINDA M DAIRIKI | Director | 08/13/2012 | 85,000 |
| SHORTLIFFE LINDA M DAIRIKI | Director | 08/13/2012 | 440,000 |
| SHORTLIFFE LINDA M DAIRIKI | Director | 08/10/2012 | 537,500 |
| MARIO ERNEST | Director | 08/10/2012 | 107,500 |
| MARIO ERNEST | Director | 08/09/2012 | 327,399 |
| Slebir John L | VP, General Counsel | 07/18/2012 | 72,712 |
| Slebir John L | VP, General Counsel | 07/18/2012 | 303,600 |
| TAM PETER Y | President | 07/18/2012 | 106,250 |
| TAM PETER Y | President | 07/18/2012 | 773,750 |
| Day Wesley | VP, Clinical Research | 07/18/2012 | 510,048 |
| MORRIS TIMOTHY E | VP, Finance and CFO | 07/18/2012 | 105,750 |
| MORRIS TIMOTHY E | VP, Finance and CFO | 07/18/2012 | 759,000 |
| WILSON LELAND F | CEO | 07/18/2012 | 333,754 |
| WILSON LELAND F | CEO | 07/18/2012 | 3,036,000 |
| MARSH GUY P | VP, Operations and General Mgr | 07/18/2012 | 169,664 |
| MARSH GUY P | VP, Operations and General Mgr | 07/18/2012 | 1,098,759 |
| MILLER MICHAEL PATRICK | Chief Commercial Officer | 07/18/2012 | 254,750 |
| MILLER MICHAEL PATRICK | Chief Commercial Officer | 07/18/2012 | 759,000 |
| WILSON LELAND F | CEO | 06/27/2012 | 207,500 |
| WILSON LELAND F | CEO | 06/27/2012 | 1,400,000 |
| MILLER MICHAEL PATRICK | Chief Commercial Officer | 06/27/2012 | 254,750 |
| MILLER MICHAEL PATRICK | Chief Commercial Officer | 06/27/2012 | 701,900 |
| TAM PETER Y | President | 06/19/2012 | 74,600 |
| TAM PETER Y | President | 06/19/2012 | 545,000 |
| TAM PETER Y | President | 06/18/2012 | 74,600 |
| TAM PETER Y | President | 06/18/2012 | 529,000 |
| TAM PETER Y | President | 06/14/2012 | 1,515,000 |
| TAM PETER Y | President | 06/14/2012 | 932,550 |
| TAM PETER Y | President | 06/14/2012 | 5,973,534 |
| MILLER MICHAEL PATRICK | Chief Commercial Officer | 06/12/2012 | 254,750 |
| MILLER MICHAEL PATRICK | Chief Commercial Officer | 06/12/2012 | 625,000 |
| WILSON LELAND F | CEO | 06/11/2012 | 207,500 |
| WILSON LELAND F | CEO | 06/11/2012 | 1,259,000 |
| LOGAN MARK B | Director | 03/16/2012 | 50,540 |
| LOGAN MARK B | Director | 03/16/2012 | 284,453 |
| MARSH GUY P | VP, Operations & General Mgr. | 03/15/2012 | 134,148 |
| CASAMENTO CHARLES J | Director | 03/12/2012 | 328,460 |
| CASAMENTO CHARLES J | Director | 03/12/2012 | 745,217 |
| SHORTLIFFE LINDA M DAIRIKI | Director | 03/08/2012 | 227,100 |
| SHORTLIFFE LINDA M DAIRIKI | Director | 03/08/2012 | 1,118,000 |
| Perry Lee | VP & Chief Accounting Officer | 03/09/2012 | 561,142 |
| Perry Lee | VP & Chief Accounting Officer | 03/09/2012 | 1,836,210 |
| CASAMENTO CHARLES J | Director | 02/27/2012 | 216,040 |
| WILSON LELAND F | CEO | 02/27/2012 | 215,732 |
| WILSON LELAND F | CEO | 02/27/2012 | 1,250,000 |
| MARSH GUY P | VP, Operations and General Mgr | 02/27/2012 | 327,722 |
| MARSH GUY P | VP, Operations and General Mgr | 02/27/2012 | 1,079,499 |
| MORRIS TIMOTHY E | SVP, Finance and CFO | 02/24/2012 | 141,750 |
| MORRIS TIMOTHY E | SVP, Finance and CFO | 02/23/2012 | 1,293,586 |
| MORRIS TIMOTHY E | SVP, Finance and CFO | 02/27/2012 | 247,500 |
| MORRIS TIMOTHY E | SVP, Finance and CFO | 02/23/2012 | 5,267,917 |
| MORRIS TIMOTHY E | SVP, Finance and CFO | 02/27/2012 | 1,195,750 |
| MORRIS TIMOTHY E | SVP, Finance and CFO | 02/24/2012 | 538,750 |
| WILSON LELAND F | Chief Executive Officer | 02/23/2012 | 642,267 |
| WILSON LELAND F | Chief Executive Officer | 02/23/2012 | 3,103,500 |
| MARSH GUY P | VP, Operations & General Mgr. | 02/23/2012 | 367,611 |
| MARSH GUY P | VP, Operations & General Mgr. | 02/23/2012 | 1,796,284 |
| Day Wesley | VP, Clinical Development | 02/23/2012 | 330,162 |
| Day Wesley | VP, Clinical Development | 02/23/2012 | 1,654,331 |
| Perry Lee | VP & Chief Accounting Officer | 02/23/2012 | 805,876 |
| Perry Lee | VP & Chief Accounting Officer | 02/23/2012 | 3,555,204 |
| TAM PETER Y | President | 01/11/2012 | 324,168 |
| TAM PETER Y | President | 01/10/2012 | 148,632 |
| Perry Lee | VP & Chief Accounting Officer | 01/09/2012 | 119,761 |
| Perry Lee | VP & Chief Accounting Officer | 01/09/2012 | 466,475 |
| Day Wesley | VP, Clinical Development | 01/09/2012 | 98,400 |
| Day Wesley | VP, Clinical Development | 01/09/2012 | 345,000 |
| CASAMENTO CHARLES J | Director | 12/06/2011 | 105,750 |
| Day Wesley | VP, Clinical Development | 11/11/2011 | 76,380 |
| Day Wesley | VP, Clinical Development | 11/11/2011 | 231,349 |
| TAM PETER Y | President | 07/11/2011 | 17,000 |
| Day Wesley | VP, Clinical Development | 12/17/2010 | 673,446 |
| TAM PETER Y | President | 12/16/2010 | 72,656 |
| TAM PETER Y | President | 12/16/2010 | 92,807 |
| LOGAN MARK B | Director | 12/15/2010 | 103,180 |
| LOGAN MARK B | Director | 12/17/2010 | 73,380 |
| LOGAN MARK B | Director | 12/15/2010 | 164,520 |
| LOGAN MARK B | Director | 12/17/2010 | 190,338 |
| SHORTLIFFE LINDA M DAIRIKI | Director | 12/15/2010 | 31,680 |
| SHORTLIFFE LINDA M DAIRIKI | Director | 12/15/2010 | 74,480 |
| Day Wesley | VP, Clinical Development | 12/17/2010 | 195,600 |
| Day Wesley | VP, Clinical Development | 12/17/2010 | 635,491 |
| WILSON LELAND F | Chief Executive Officer | 12/15/2010 | 387,500 |
| WILSON LELAND F | Chief Executive Officer | 12/15/2010 | 568,156 |
| LOGAN MARK B | Director | 07/22/2010 | 31,680 |
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