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INSIDER TRANSACTIONS FOR
| Owner | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| Tanimoto Sarina | CHIEF MEDICAL OFFICER | Apr 16, 2024 | Sale | $9.28 | 50,000 | 464,020 | 1,647,447 | Apr 17, 2024, 06:42 PM |
| Tanimoto Sarina | CHIEF MEDICAL OFFICER | Apr 16, 2024 | Sale | $9.28 | 50,000 | 463,985 | 1,848,499 | Apr 17, 2024, 06:42 PM |
| Lowenthal Richard E | PRESIDENT AND CEO | Apr 16, 2024 | Sale | $9.28 | 50,000 | 463,985 | 1,848,499 | Apr 17, 2024, 06:40 PM |
| Lowenthal Richard E | PRESIDENT AND CEO | Apr 16, 2024 | Sale | $9.28 | 50,000 | 464,020 | 1,647,447 | Apr 17, 2024, 06:40 PM |
| Tanimoto Sarina | CHIEF MEDICAL OFFICER | Apr 09, 2024 | Sale | $9.28 | 50,000 | 463,850 | 1,898,499 | Apr 10, 2024, 05:39 PM |
| Tanimoto Sarina | CHIEF MEDICAL OFFICER | Apr 09, 2024 | Sale | $9.28 | 50,000 | 463,885 | 1,646,494 | Apr 10, 2024, 05:39 PM |
| Lowenthal Richard E | PRESIDENT AND CEO | Apr 09, 2024 | Sale | $9.28 | 50,000 | 463,850 | 1,898,499 | Apr 10, 2024, 05:36 PM |
| Lowenthal Richard E | PRESIDENT AND CEO | Apr 09, 2024 | Sale | $9.28 | 50,000 | 463,885 | 1,646,494 | Apr 10, 2024, 05:36 PM |
| RA CAPITAL MANAGEMENT, L.P. | Director | Mar 27, 2024 | Buy | $9.79 | 505,954 | 4,953,290 | 9,958,073 | Mar 27, 2024, 07:37 PM |
| RA CAPITAL MANAGEMENT, L.P. | Director | Mar 26, 2024 | Buy | $9.55 | 457,745 | 4,371,465 | 9,452,119 | Mar 27, 2024, 07:37 PM |
| RA CAPITAL MANAGEMENT, L.P. | Director | Mar 25, 2024 | Buy | $9.06 | 437,600 | 3,964,656 | 8,994,374 | Mar 27, 2024, 07:37 PM |
| Lowenthal Richard E | PRESIDENT AND CEO | Mar 22, 2024 | Sale | $9.03 | 1,017 | 9,183 | 1,745,082 | Mar 26, 2024, 06:48 PM |
| Lowenthal Richard E | PRESIDENT AND CEO | Mar 25, 2024 | Sale | $9.12 | 47,632 | 434,575 | 1,948,499 | Mar 26, 2024, 06:48 PM |
| Lowenthal Richard E | PRESIDENT AND CEO | Mar 25, 2024 | Sale | $9.12 | 47,635 | 434,612 | 1,697,447 | Mar 26, 2024, 06:48 PM |
| Lowenthal Richard E | PRESIDENT AND CEO | Mar 22, 2024 | Sale | $9.01 | 1,326 | 11,952 | 1,996,131 | Mar 26, 2024, 06:48 PM |
| Tanimoto Sarina | CHIEF MEDICAL OFFICER | Mar 25, 2024 | Sale | $9.12 | 47,632 | 434,575 | 1,948,499 | Mar 26, 2024, 06:47 PM |
| Tanimoto Sarina | CHIEF MEDICAL OFFICER | Mar 25, 2024 | Sale | $9.12 | 47,635 | 434,612 | 1,697,447 | Mar 26, 2024, 06:47 PM |
| Tanimoto Sarina | CHIEF MEDICAL OFFICER | Mar 22, 2024 | Sale | $9.01 | 1,326 | 11,952 | 1,996,131 | Mar 26, 2024, 06:47 PM |
| Tanimoto Sarina | CHIEF MEDICAL OFFICER | Mar 22, 2024 | Sale | $9.03 | 1,017 | 9,183 | 1,745,082 | Mar 26, 2024, 06:47 PM |
| Lowenthal Richard E | PRESIDENT AND CEO | Mar 19, 2024 | Sale | $9.04 | 942 | 8,513 | 1,997,557 | Mar 21, 2024, 09:51 PM |
| Lowenthal Richard E | PRESIDENT AND CEO | Mar 19, 2024 | Sale | $9.03 | 976 | 8,811 | 1,746,471 | Mar 21, 2024, 09:51 PM |
| Lowenthal Richard E | PRESIDENT AND CEO | Mar 21, 2024 | Sale | $9.00 | 100 | 900 | 1,997,457 | Mar 21, 2024, 09:51 PM |
| Lowenthal Richard E | PRESIDENT AND CEO | Mar 21, 2024 | Sale | $9.00 | 372 | 3,348 | 1,746,099 | Mar 21, 2024, 09:51 PM |
| Tanimoto Sarina | CHIEF MEDICAL OFFICER | Mar 21, 2024 | Sale | $9.00 | 100 | 900 | 1,997,457 | Mar 21, 2024, 09:50 PM |
| Tanimoto Sarina | CHIEF MEDICAL OFFICER | Mar 21, 2024 | Sale | $9.00 | 372 | 3,348 | 1,746,099 | Mar 21, 2024, 09:50 PM |
| Tanimoto Sarina | CHIEF MEDICAL OFFICER | Mar 19, 2024 | Sale | $9.04 | 942 | 8,513 | 1,997,557 | Mar 21, 2024, 09:50 PM |
| Tanimoto Sarina | CHIEF MEDICAL OFFICER | Mar 19, 2024 | Sale | $9.03 | 976 | 8,811 | 1,746,471 | Mar 21, 2024, 09:50 PM |
| Lowenthal Richard E | PRESIDENT AND CEO | Mar 15, 2024 | Sale | $9.14 | 48,461 | 442,997 | 1,998,499 | Mar 15, 2024, 07:55 PM |
| Lowenthal Richard E | PRESIDENT AND CEO | Mar 15, 2024 | Sale | $9.14 | 48,295 | 441,489 | 1,696,494 | Mar 15, 2024, 07:55 PM |
| Lowenthal Richard E | PRESIDENT AND CEO | Mar 14, 2024 | Sale | $9.00 | 239 | 2,151 | 2,046,960 | Mar 15, 2024, 07:55 PM |
| Lowenthal Richard E | PRESIDENT AND CEO | Mar 14, 2024 | Sale | $9.00 | 205 | 1,845 | 1,744,789 | Mar 15, 2024, 07:55 PM |
| Lowenthal Richard E | PRESIDENT AND CEO | Mar 13, 2024 | Sale | $9.00 | 1,300 | 11,700 | 2,047,199 | Mar 15, 2024, 07:55 PM |
| Lowenthal Richard E | PRESIDENT AND CEO | Mar 13, 2024 | Sale | $9.00 | 1,500 | 13,500 | 1,744,994 | Mar 15, 2024, 07:55 PM |
| Tanimoto Sarina | CHIEF MEDICAL OFFICER | Mar 15, 2024 | Sale | $9.14 | 48,461 | 442,997 | 1,998,499 | Mar 15, 2024, 07:52 PM |
| Tanimoto Sarina | CHIEF MEDICAL OFFICER | Mar 15, 2024 | Sale | $9.14 | 48,295 | 441,489 | 1,696,494 | Mar 15, 2024, 07:52 PM |
| Tanimoto Sarina | CHIEF MEDICAL OFFICER | Mar 14, 2024 | Sale | $9.00 | 239 | 2,151 | 2,046,960 | Mar 15, 2024, 07:52 PM |
| Tanimoto Sarina | CHIEF MEDICAL OFFICER | Mar 14, 2024 | Sale | $9.00 | 205 | 1,845 | 1,744,789 | Mar 15, 2024, 07:52 PM |
| Tanimoto Sarina | CHIEF MEDICAL OFFICER | Mar 13, 2024 | Sale | $9.00 | 1,300 | 11,700 | 2,047,199 | Mar 15, 2024, 07:52 PM |
| Tanimoto Sarina | CHIEF MEDICAL OFFICER | Mar 13, 2024 | Sale | $9.00 | 1,500 | 13,500 | 1,744,994 | Mar 15, 2024, 07:52 PM |
| Tanimoto Sarina | CHIEF MEDICAL OFFICER | Feb 29, 2024 | Sale | $9.01 | 1,982 | 17,867 | 2,048,499 | Mar 01, 2024, 08:21 PM |
| Tanimoto Sarina | CHIEF MEDICAL OFFICER | Feb 29, 2024 | Sale | $9.02 | 800 | 7,215 | 1,746,494 | Mar 01, 2024, 08:21 PM |
| Tanimoto Sarina | CHIEF MEDICAL OFFICER | Feb 29, 2024 | Sale | $9.02 | 1,000 | 9,019 | 1,747,447 | Mar 01, 2024, 08:21 PM |
| Lowenthal Richard E | PRESIDENT AND CEO | Feb 29, 2024 | Sale | $9.02 | 1,000 | 9,019 | 1,747,447 | Mar 01, 2024, 08:17 PM |
| Lowenthal Richard E | PRESIDENT AND CEO | Feb 29, 2024 | Sale | $9.01 | 1,982 | 17,867 | 2,048,499 | Mar 01, 2024, 08:17 PM |
| Lowenthal Richard E | PRESIDENT AND CEO | Feb 29, 2024 | Sale | $9.02 | 800 | 7,215 | 1,746,494 | Mar 01, 2024, 08:17 PM |
| Tanimoto Sarina | CHIEF MEDICAL OFFICER | Feb 28, 2024 | Sale | $9.02 | 25,456 | 229,626 | 1,747,294 | Feb 28, 2024, 09:08 PM |
| Tanimoto Sarina | CHIEF MEDICAL OFFICER | Feb 26, 2024 | Sale | $9.01 | 100 | 901 | 1,772,750 | Feb 28, 2024, 09:08 PM |
| Tanimoto Sarina | CHIEF MEDICAL OFFICER | Feb 26, 2024 | Sale | $9.01 | 500 | 4,505 | 2,099,500 | Feb 28, 2024, 09:08 PM |
| Tanimoto Sarina | CHIEF MEDICAL OFFICER | Feb 26, 2024 | Sale | $9.01 | 100 | 901 | 1,772,750 | Feb 28, 2024, 09:08 PM |
| Tanimoto Sarina | CHIEF MEDICAL OFFICER | Feb 28, 2024 | Sale | $9.02 | 24,303 | 219,225 | 1,748,447 | Feb 28, 2024, 09:08 PM |
| Tanimoto Sarina | CHIEF MEDICAL OFFICER | Feb 28, 2024 | Sale | $9.02 | 49,019 | 442,210 | 2,050,481 | Feb 28, 2024, 09:08 PM |
| Lowenthal Richard E | PRESIDENT AND CEO | Feb 28, 2024 | Sale | $9.02 | 25,456 | 229,626 | 1,747,294 | Feb 28, 2024, 09:04 PM |
| Lowenthal Richard E | PRESIDENT AND CEO | Feb 26, 2024 | Sale | $9.01 | 100 | 901 | 1,772,750 | Feb 28, 2024, 09:04 PM |
| Lowenthal Richard E | PRESIDENT AND CEO | Feb 26, 2024 | Sale | $9.01 | 500 | 4,505 | 2,099,500 | Feb 28, 2024, 09:04 PM |
| Lowenthal Richard E | PRESIDENT AND CEO | Feb 26, 2024 | Sale | $9.01 | 100 | 901 | 1,772,750 | Feb 28, 2024, 09:04 PM |
| Lowenthal Richard E | PRESIDENT AND CEO | Feb 28, 2024 | Sale | $9.02 | 24,303 | 219,225 | 1,748,447 | Feb 28, 2024, 09:04 PM |
| Lowenthal Richard E | PRESIDENT AND CEO | Feb 28, 2024 | Sale | $9.02 | 49,019 | 442,210 | 2,050,481 | Feb 28, 2024, 09:04 PM |
| Fitzpatrick Alexander A | Chief Legal Officer | Sep 29, 2023 | Buy | $3.78 | 46,258 | 174,994 | 89,227 | Oct 02, 2023, 04:23 PM |
| Fitzpatrick Alexander A | Chief Legal Officer | Sep 28, 2023 | Buy | $3.62 | 40,000 | 144,960 | 42,969 | Oct 02, 2023, 04:23 PM |
| RA CAPITAL MANAGEMENT, L.P. | Director | Sep 21, 2023 | Buy | $3.03 | 2,700,000 | 8,183,526 | 8,556,774 | Sep 25, 2023, 04:30 PM |
| Shawver Laura | Director | Sep 01, 2023 | Option Exercise | $1.27 | 100,000 | 127,000 | 310,346 | Sep 05, 2023, 08:04 PM |
| Shawver Laura | Director | Sep 01, 2023 | Sale | $7.71 | 100,000 | 770,520 | 210,346 | Sep 05, 2023, 08:04 PM |
| RA CAPITAL MANAGEMENT, L.P. | Director | Aug 29, 2023 | Buy | $6.20 | 3,750,000 | 23,249,999 | 5,856,774 | Aug 31, 2023, 05:26 PM |
| ORBIMED ADVISORS LLC | Director | Aug 29, 2023 | Buy | $6.20 | 500,000 | 3,100,000 | 8,019,187 | Aug 31, 2023, 05:26 PM |
| Thompson Peter A. | Director | Aug 29, 2023 | Buy | $6.20 | 500,000 | 3,100,000 | 8,019,187 | Aug 31, 2023, 05:18 PM |
| Shawver Laura | Director | Aug 04, 2023 | Option Exercise | $1.27 | 18,897 | 23,999 | 229,243 | Aug 07, 2023, 05:05 PM |
| Shawver Laura | Director | Aug 03, 2023 | Option Exercise | $1.27 | 26,107 | 33,156 | 236,453 | Aug 07, 2023, 05:05 PM |
| Shawver Laura | Director | Aug 03, 2023 | Sale | $7.01 | 26,107 | 183,018 | 210,346 | Aug 07, 2023, 05:05 PM |
| Shawver Laura | Director | Aug 04, 2023 | Sale | $7.06 | 18,897 | 133,471 | 210,346 | Aug 07, 2023, 05:05 PM |
| Shawver Laura | Director | Aug 02, 2023 | Option Exercise | $1.27 | 36,281 | 46,077 | 246,627 | Aug 03, 2023, 06:03 PM |
| Shawver Laura | Director | Aug 01, 2023 | Option Exercise | $1.27 | 18,715 | 23,768 | 229,061 | Aug 03, 2023, 06:03 PM |
| Shawver Laura | Director | Aug 02, 2023 | Sale | $7.09 | 36,281 | 257,265 | 210,346 | Aug 03, 2023, 06:03 PM |
| Shawver Laura | Director | Aug 01, 2023 | Sale | $7.19 | 18,715 | 134,576 | 210,346 | Aug 03, 2023, 06:03 PM |
| Shawver Laura | Director | Jul 07, 2023 | Option Exercise | $1.27 | 8,858 | 11,250 | 219,204 | Jul 07, 2023, 08:16 PM |
| Shawver Laura | Director | Jul 07, 2023 | Sale | $6.36 | 8,858 | 56,372 | 210,346 | Jul 07, 2023, 08:16 PM |
| Shawver Laura | Director | Jul 03, 2023 | Option Exercise | $1.27 | 26,520 | 33,680 | 236,866 | Jul 06, 2023, 08:55 PM |
| Shawver Laura | Director | Jul 06, 2023 | Option Exercise | $1.27 | 33,510 | 42,558 | 243,856 | Jul 06, 2023, 08:55 PM |
| Shawver Laura | Director | Jul 05, 2023 | Option Exercise | $1.27 | 31,112 | 39,512 | 241,458 | Jul 06, 2023, 08:55 PM |
| Shawver Laura | Director | Jul 03, 2023 | Sale | $6.72 | 26,520 | 178,347 | 210,346 | Jul 06, 2023, 08:55 PM |
| Shawver Laura | Director | Jul 06, 2023 | Sale | $6.34 | 33,510 | 212,554 | 210,346 | Jul 06, 2023, 08:55 PM |
| Shawver Laura | Director | Jul 05, 2023 | Sale | $6.41 | 31,112 | 199,552 | 210,346 | Jul 06, 2023, 08:55 PM |
| Shawver Laura | Director | Jun 02, 2023 | Option Exercise | $1.27 | 26,941 | 34,215 | 237,287 | Jun 02, 2023, 07:48 PM |
| Shawver Laura | Director | Jun 01, 2023 | Option Exercise | $1.27 | 73,059 | 92,785 | 283,405 | Jun 02, 2023, 07:48 PM |
| Shawver Laura | Director | Jun 02, 2023 | Sale | $6.95 | 26,941 | 187,240 | 210,346 | Jun 02, 2023, 07:48 PM |
| Shawver Laura | Director | Jun 01, 2023 | Sale | $6.80 | 73,059 | 496,801 | 210,346 | Jun 02, 2023, 07:48 PM |
| Shawver Laura | Director | May 09, 2023 | Option Exercise | $1.27 | 42,900 | 54,483 | 253,246 | May 10, 2023, 04:53 PM |
| Shawver Laura | Director | May 08, 2023 | Option Exercise | $1.27 | 57,100 | 72,517 | 267,446 | May 10, 2023, 04:53 PM |
| Shawver Laura | Director | May 09, 2023 | Sale | $5.31 | 42,900 | 227,799 | 210,346 | May 10, 2023, 04:53 PM |
| Shawver Laura | Director | May 08, 2023 | Sale | $6.16 | 57,100 | 351,736 | 210,346 | May 10, 2023, 04:53 PM |
| Shawver Laura | Director | Nov 09, 2022 | Sale | $4.58 | 43,896 | 201,044 | 210,346 | May 10, 2023, 04:53 PM |
| Scott Kathleen D. | Chief Financial Officer | Nov 29, 2022 | Buy | $6.24 | 8,250 | 51,506 | 8,250 | Dec 01, 2022, 04:31 PM |
| Shawver Laura | Chief Executive Officer | Aug 05, 2022 | Option Exercise | $1.27 | 78,740 | 100,000 | 254,242 | Aug 09, 2022, 04:38 PM |
| ROOT JONATHAN D | Director | Nov 15, 2021 | Buy | $8.85 | 2,014 | 17,824 | 2,364 | Mar 18, 2022, 05:14 PM |
| ROOT JONATHAN D | Director | Mar 03, 2021 | Buy | $52.07 | 350 | 18,224 | 350 | Mar 18, 2022, 05:14 PM |
| Hawkinson Russ | Sr. Vice President of Finance | Dec 08, 2020 | Buy | $21.00 | 200 | 4,200 | 200 | Feb 24, 2022, 07:55 PM |
| Presidio Management Group XII, L.L.C. | 10% Owner | Dec 08, 2020 | Buy | $21.00 | 47,619 | 999,999 | 47,619 | Dec 08, 2020, 09:04 PM |
| CAPPS VICKIE L | Director | Dec 08, 2020 | Buy | $21.00 | 9,523 | 199,983 | 61,576 | Dec 08, 2020, 08:56 PM |
| Hawkinson Russ | Sr. Vice President of Finance | Dec 08, 2020 | Buy | $21.00 | 238 | 4,998 | 238 | Dec 08, 2020, 08:52 PM |
| Piazza Jonathan | Chief Financial Officer | Dec 08, 2020 | Buy | $21.00 | 11,904 | 249,984 | 11,904 | Dec 08, 2020, 08:50 PM |
| Schroeder Thilo | Director | Dec 08, 2020 | Buy | $21.00 | 238,096 | 5,000,016 | 238,096 | Dec 08, 2020, 08:48 PM |
| ROOT JONATHAN D | Director | Dec 08, 2020 | Buy | $21.00 | 95,238 | 1,999,998 | 95,238 | Dec 08, 2020, 08:46 PM |
| Thompson Peter A. | Director | Dec 08, 2020 | Buy | $21.00 | 952,377 | 19,999,917 | 952,377 | Dec 08, 2020, 08:43 PM |
| Thompson Peter A. | Director | Dec 08, 2020 | Buy | $21.00 | 238,100 | 5,000,100 | 507,423 | Dec 08, 2020, 08:43 PM |
| ORBIMED ADVISORS LLC | Director | Dec 08, 2020 | Buy | $21.00 | 952,377 | 19,999,917 | 952,377 | Dec 08, 2020, 08:41 PM |
| ORBIMED ADVISORS LLC | Director | Dec 08, 2020 | Buy | $21.00 | 238,100 | 5,000,100 | 507,423 | Dec 08, 2020, 08:41 PM |
Load More Insider Transactions
Buy
Sale
Option Exercise
| Owner | Relationship | Date | Value($) |
| Tanimoto Sarina | CHIEF MEDICAL OFFICER | 04/16/2024 | 464,020 |
| Tanimoto Sarina | CHIEF MEDICAL OFFICER | 04/16/2024 | 463,985 |
| Lowenthal Richard E | PRESIDENT AND CEO | 04/16/2024 | 463,985 |
| Lowenthal Richard E | PRESIDENT AND CEO | 04/16/2024 | 464,020 |
| Tanimoto Sarina | CHIEF MEDICAL OFFICER | 04/09/2024 | 463,850 |
| Tanimoto Sarina | CHIEF MEDICAL OFFICER | 04/09/2024 | 463,885 |
| Lowenthal Richard E | PRESIDENT AND CEO | 04/09/2024 | 463,850 |
| Lowenthal Richard E | PRESIDENT AND CEO | 04/09/2024 | 463,885 |
| RA CAPITAL MANAGEMENT, L.P. | Director | 03/27/2024 | 4,953,290 |
| RA CAPITAL MANAGEMENT, L.P. | Director | 03/26/2024 | 4,371,465 |
| RA CAPITAL MANAGEMENT, L.P. | Director | 03/25/2024 | 3,964,656 |
| Lowenthal Richard E | PRESIDENT AND CEO | 03/22/2024 | 9,183 |
| Lowenthal Richard E | PRESIDENT AND CEO | 03/25/2024 | 434,575 |
| Lowenthal Richard E | PRESIDENT AND CEO | 03/25/2024 | 434,612 |
| Lowenthal Richard E | PRESIDENT AND CEO | 03/22/2024 | 11,952 |
| Tanimoto Sarina | CHIEF MEDICAL OFFICER | 03/25/2024 | 434,575 |
| Tanimoto Sarina | CHIEF MEDICAL OFFICER | 03/25/2024 | 434,612 |
| Tanimoto Sarina | CHIEF MEDICAL OFFICER | 03/22/2024 | 11,952 |
| Tanimoto Sarina | CHIEF MEDICAL OFFICER | 03/22/2024 | 9,183 |
| Lowenthal Richard E | PRESIDENT AND CEO | 03/19/2024 | 8,513 |
| Lowenthal Richard E | PRESIDENT AND CEO | 03/19/2024 | 8,811 |
| Lowenthal Richard E | PRESIDENT AND CEO | 03/21/2024 | 900 |
| Lowenthal Richard E | PRESIDENT AND CEO | 03/21/2024 | 3,348 |
| Tanimoto Sarina | CHIEF MEDICAL OFFICER | 03/21/2024 | 900 |
| Tanimoto Sarina | CHIEF MEDICAL OFFICER | 03/21/2024 | 3,348 |
| Tanimoto Sarina | CHIEF MEDICAL OFFICER | 03/19/2024 | 8,513 |
| Tanimoto Sarina | CHIEF MEDICAL OFFICER | 03/19/2024 | 8,811 |
| Lowenthal Richard E | PRESIDENT AND CEO | 03/15/2024 | 442,997 |
| Lowenthal Richard E | PRESIDENT AND CEO | 03/15/2024 | 441,489 |
| Lowenthal Richard E | PRESIDENT AND CEO | 03/14/2024 | 2,151 |
| Lowenthal Richard E | PRESIDENT AND CEO | 03/14/2024 | 1,845 |
| Lowenthal Richard E | PRESIDENT AND CEO | 03/13/2024 | 11,700 |
| Lowenthal Richard E | PRESIDENT AND CEO | 03/13/2024 | 13,500 |
| Tanimoto Sarina | CHIEF MEDICAL OFFICER | 03/15/2024 | 442,997 |
| Tanimoto Sarina | CHIEF MEDICAL OFFICER | 03/15/2024 | 441,489 |
| Tanimoto Sarina | CHIEF MEDICAL OFFICER | 03/14/2024 | 2,151 |
| Tanimoto Sarina | CHIEF MEDICAL OFFICER | 03/14/2024 | 1,845 |
| Tanimoto Sarina | CHIEF MEDICAL OFFICER | 03/13/2024 | 11,700 |
| Tanimoto Sarina | CHIEF MEDICAL OFFICER | 03/13/2024 | 13,500 |
| Tanimoto Sarina | CHIEF MEDICAL OFFICER | 02/29/2024 | 17,867 |
| Tanimoto Sarina | CHIEF MEDICAL OFFICER | 02/29/2024 | 7,215 |
| Tanimoto Sarina | CHIEF MEDICAL OFFICER | 02/29/2024 | 9,019 |
| Lowenthal Richard E | PRESIDENT AND CEO | 02/29/2024 | 9,019 |
| Lowenthal Richard E | PRESIDENT AND CEO | 02/29/2024 | 17,867 |
| Lowenthal Richard E | PRESIDENT AND CEO | 02/29/2024 | 7,215 |
| Tanimoto Sarina | CHIEF MEDICAL OFFICER | 02/28/2024 | 229,626 |
| Tanimoto Sarina | CHIEF MEDICAL OFFICER | 02/26/2024 | 901 |
| Tanimoto Sarina | CHIEF MEDICAL OFFICER | 02/26/2024 | 4,505 |
| Tanimoto Sarina | CHIEF MEDICAL OFFICER | 02/26/2024 | 901 |
| Tanimoto Sarina | CHIEF MEDICAL OFFICER | 02/28/2024 | 219,225 |
| Tanimoto Sarina | CHIEF MEDICAL OFFICER | 02/28/2024 | 442,210 |
| Lowenthal Richard E | PRESIDENT AND CEO | 02/28/2024 | 229,626 |
| Lowenthal Richard E | PRESIDENT AND CEO | 02/26/2024 | 901 |
| Lowenthal Richard E | PRESIDENT AND CEO | 02/26/2024 | 4,505 |
| Lowenthal Richard E | PRESIDENT AND CEO | 02/26/2024 | 901 |
| Lowenthal Richard E | PRESIDENT AND CEO | 02/28/2024 | 219,225 |
| Lowenthal Richard E | PRESIDENT AND CEO | 02/28/2024 | 442,210 |
| Fitzpatrick Alexander A | Chief Legal Officer | 09/29/2023 | 174,994 |
| Fitzpatrick Alexander A | Chief Legal Officer | 09/28/2023 | 144,960 |
| RA CAPITAL MANAGEMENT, L.P. | Director | 09/21/2023 | 8,183,526 |
| Shawver Laura | Director | 09/01/2023 | 127,000 |
| Shawver Laura | Director | 09/01/2023 | 770,520 |
| RA CAPITAL MANAGEMENT, L.P. | Director | 08/29/2023 | 23,249,999 |
| ORBIMED ADVISORS LLC | Director | 08/29/2023 | 3,100,000 |
| Thompson Peter A. | Director | 08/29/2023 | 3,100,000 |
| Shawver Laura | Director | 08/04/2023 | 23,999 |
| Shawver Laura | Director | 08/03/2023 | 33,156 |
| Shawver Laura | Director | 08/03/2023 | 183,018 |
| Shawver Laura | Director | 08/04/2023 | 133,471 |
| Shawver Laura | Director | 08/02/2023 | 46,077 |
| Shawver Laura | Director | 08/01/2023 | 23,768 |
| Shawver Laura | Director | 08/02/2023 | 257,265 |
| Shawver Laura | Director | 08/01/2023 | 134,576 |
| Shawver Laura | Director | 07/07/2023 | 11,250 |
| Shawver Laura | Director | 07/07/2023 | 56,372 |
| Shawver Laura | Director | 07/03/2023 | 33,680 |
| Shawver Laura | Director | 07/06/2023 | 42,558 |
| Shawver Laura | Director | 07/05/2023 | 39,512 |
| Shawver Laura | Director | 07/03/2023 | 178,347 |
| Shawver Laura | Director | 07/06/2023 | 212,554 |
| Shawver Laura | Director | 07/05/2023 | 199,552 |
| Shawver Laura | Director | 06/02/2023 | 34,215 |
| Shawver Laura | Director | 06/01/2023 | 92,785 |
| Shawver Laura | Director | 06/02/2023 | 187,240 |
| Shawver Laura | Director | 06/01/2023 | 496,801 |
| Shawver Laura | Director | 05/09/2023 | 54,483 |
| Shawver Laura | Director | 05/08/2023 | 72,517 |
| Shawver Laura | Director | 05/09/2023 | 227,799 |
| Shawver Laura | Director | 05/08/2023 | 351,736 |
| Shawver Laura | Director | 11/09/2022 | 201,044 |
| Scott Kathleen D. | Chief Financial Officer | 11/29/2022 | 51,506 |
| Shawver Laura | Chief Executive Officer | 08/05/2022 | 100,000 |
| ROOT JONATHAN D | Director | 11/15/2021 | 17,824 |
| ROOT JONATHAN D | Director | 03/03/2021 | 18,224 |
| Hawkinson Russ | Sr. Vice President of Finance | 12/08/2020 | 4,200 |
| Presidio Management Group XII, L.L.C. | 10% Owner | 12/08/2020 | 999,999 |
| CAPPS VICKIE L | Director | 12/08/2020 | 199,983 |
| Hawkinson Russ | Sr. Vice President of Finance | 12/08/2020 | 4,998 |
| Piazza Jonathan | Chief Financial Officer | 12/08/2020 | 249,984 |
| Schroeder Thilo | Director | 12/08/2020 | 5,000,016 |
| ROOT JONATHAN D | Director | 12/08/2020 | 1,999,998 |
| Thompson Peter A. | Director | 12/08/2020 | 19,999,917 |
| Thompson Peter A. | Director | 12/08/2020 | 5,000,100 |
| ORBIMED ADVISORS LLC | Director | 12/08/2020 | 19,999,917 |
| ORBIMED ADVISORS LLC | Director | 12/08/2020 | 5,000,100 |
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CHANGE IN SHARES OUTSTANDING FOR
STOCK BUYBACKS FOR
Period of Report: 12/31/2023
10-K/10-Q Filings: View
Previous Period
% Change in Shares
Quarter
09/30/2023
0.58%
1Q
06/30/2023
1.29%
2Q
03/31/2023
2.02%
3Q
BUYBACK ANNOUNCEMENT(S) FOR
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