. (RLYP)
$31.99 - (-)
Market Cap: -
As of 07/22/19 12:00 AM EDT. Market closed.
. (RLYP)
$31.99
- (-)
Market Cap: -
As of 07/22/19 12:00 AM EDT. Market closed.
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52 week range
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Avg. Volume (30 days)
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Dividend Yield
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Previous Close
$31.99
Days Range
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52 week range
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Volume
0
Avg. Volume (30 days)
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Dividend Yield
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INSIDER TRANSACTIONS FOR
| Owner | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| Torley Helen | Director | Sep 01, 2016 | Option Exercise | $32.00 | 2,250 | 72,000 | 0 | Sep 02, 2016, 12:39 PM |
| Torley Helen | Director | Sep 01, 2016 | Option Exercise | $32.00 | 1,237 | 39,584 | 2,250 | Sep 02, 2016, 12:39 PM |
| SPIEGELMAN DANIEL K | Director | Sep 01, 2016 | Option Exercise | $32.00 | 2,250 | 72,000 | 0 | Sep 02, 2016, 12:38 PM |
| SPIEGELMAN DANIEL K | Director | Sep 01, 2016 | Option Exercise | $32.00 | 1,237 | 39,584 | 2,250 | Sep 02, 2016, 12:38 PM |
| Schuetz Thomas J. | Director | Sep 01, 2016 | Option Exercise | $32.00 | 2,250 | 72,000 | 0 | Sep 02, 2016, 12:37 PM |
| Schuetz Thomas J. | Director | Sep 01, 2016 | Option Exercise | $32.00 | 33,962 | 1,086,784 | 2,250 | Sep 02, 2016, 12:37 PM |
| MCGIRR DAVID W J | Director | Sep 01, 2016 | Option Exercise | $32.00 | 2,250 | 72,000 | 0 | Sep 02, 2016, 12:37 PM |
| MCGIRR DAVID W J | Director | Sep 01, 2016 | Option Exercise | $32.00 | 2,729 | 87,328 | 2,250 | Sep 02, 2016, 12:37 PM |
| Hillan Kenneth J. | Director | Sep 01, 2016 | Option Exercise | $32.00 | 2,250 | 72,000 | 0 | Sep 02, 2016, 12:35 PM |
| Hillan Kenneth J. | Director | Sep 01, 2016 | Option Exercise | $32.00 | 1,237 | 39,584 | 2,250 | Sep 02, 2016, 12:35 PM |
| HASTINGS PAUL J | Director | Sep 01, 2016 | Option Exercise | $32.00 | 2,250 | 72,000 | 0 | Sep 02, 2016, 12:34 PM |
| HASTINGS PAUL J | Director | Sep 01, 2016 | Option Exercise | $32.00 | 2,495 | 79,840 | 2,250 | Sep 02, 2016, 12:34 PM |
| Butler John P. | Director | Sep 01, 2016 | Option Exercise | $32.00 | 2,250 | 72,000 | 0 | Sep 02, 2016, 12:33 PM |
| Butler John P. | Director | Sep 01, 2016 | Option Exercise | $32.00 | 2,849 | 91,168 | 2,250 | Sep 02, 2016, 12:33 PM |
| Stahl Wilhelm | SVP, Chief Technology Officer | Sep 01, 2016 | Option Exercise | $32.00 | 14,167 | 453,344 | 0 | Sep 02, 2016, 12:32 PM |
| Stahl Wilhelm | SVP, Chief Technology Officer | Sep 01, 2016 | Option Exercise | $32.00 | 3,479 | 111,328 | 14,167 | Sep 02, 2016, 12:32 PM |
| Orwin John A | President & CEO | Sep 01, 2016 | Option Exercise | $32.00 | 55,000 | 1,760,000 | 0 | Sep 02, 2016, 12:31 PM |
| Orwin John A | President & CEO | Sep 01, 2016 | Option Exercise | $32.00 | 10,142 | 324,544 | 55,000 | Sep 02, 2016, 12:31 PM |
| Montgomery Monte | Chief Accounting Officer | Sep 01, 2016 | Option Exercise | $32.00 | 13,200 | 422,400 | 0 | Sep 02, 2016, 12:30 PM |
| Montgomery Monte | Chief Accounting Officer | Sep 01, 2016 | Option Exercise | $32.00 | 2,066 | 66,112 | 13,200 | Sep 02, 2016, 12:30 PM |
| Krasnow Ronald A. | See Remarks | Sep 01, 2016 | Option Exercise | $32.00 | 14,167 | 453,344 | 0 | Sep 02, 2016, 12:29 PM |
| Krasnow Ronald A. | See Remarks | Sep 01, 2016 | Option Exercise | $32.00 | 3,479 | 111,328 | 14,167 | Sep 02, 2016, 12:29 PM |
| Harrison Stephen D | SVP & Chief Scientific Officer | Sep 01, 2016 | Option Exercise | $32.00 | 16,042 | 513,344 | 0 | Sep 02, 2016, 12:28 PM |
| Harrison Stephen D | SVP & Chief Scientific Officer | Sep 01, 2016 | Option Exercise | $32.00 | 5,969 | 191,008 | 16,042 | Sep 02, 2016, 12:28 PM |
| Garland J. Scott | SVP & Chief Commercial Officer | Sep 01, 2016 | Option Exercise | $32.00 | 16,042 | 513,344 | 0 | Sep 02, 2016, 12:27 PM |
| Garland J. Scott | SVP & Chief Commercial Officer | Sep 01, 2016 | Option Exercise | $32.00 | 2,470 | 79,040 | 16,042 | Sep 02, 2016, 12:27 PM |
| Corbett Mary | Senior VP, Human Resources | Sep 01, 2016 | Option Exercise | $32.00 | 14,167 | 453,344 | 0 | Sep 02, 2016, 12:26 PM |
| Corbett Mary | Senior VP, Human Resources | Sep 01, 2016 | Option Exercise | $32.00 | 6,080 | 194,560 | 14,167 | Sep 02, 2016, 12:26 PM |
| Berman Lance | Chief Medical Officer and SVP | Sep 01, 2016 | Option Exercise | $32.00 | 20,355 | 651,360 | 0 | Sep 02, 2016, 12:26 PM |
| Berman Lance | Chief Medical Officer and SVP | Sep 01, 2016 | Option Exercise | $32.00 | 4,922 | 157,504 | 20,355 | Sep 02, 2016, 12:26 PM |
| BALL KRISTINE M | Chief Financial Officer & SVP | Sep 01, 2016 | Option Exercise | $32.00 | 20,355 | 651,360 | 0 | Sep 02, 2016, 12:25 PM |
| BALL KRISTINE M | Chief Financial Officer & SVP | Sep 01, 2016 | Option Exercise | $32.00 | 11,922 | 381,504 | 20,355 | Sep 02, 2016, 12:25 PM |
| Montgomery Monte | Chief Accounting Officer | Aug 16, 2016 | Sale | $31.92 | 510 | 16,279 | 12,539 | Aug 18, 2016, 06:47 PM |
| DONDERO JAMES D | 10% Owner | Aug 17, 2016 | Buy | $31.92 | 500 | 15,960 | 128,500 | Aug 18, 2016, 05:23 PM |
| Krasnow Ronald A. | See Remarks | Aug 15, 2016 | Option Exercise | $31.89 | 1,034 | 32,974 | 14,729 | Aug 17, 2016, 04:26 PM |
| Harrison Stephen D | SVP & Chief Scientific Officer | Aug 15, 2016 | Option Exercise | $31.89 | 705 | 22,482 | 17,844 | Aug 17, 2016, 04:25 PM |
| Garland J. Scott | SVP & Chief Commercial Officer | Aug 15, 2016 | Option Exercise | $31.89 | 705 | 22,482 | 14,345 | Aug 17, 2016, 04:24 PM |
| Corbett Mary | Senior VP, Human Resources | Aug 15, 2016 | Option Exercise | $31.89 | 1,034 | 32,974 | 17,330 | Aug 17, 2016, 04:23 PM |
| Berman Lance | Chief Medical Officer and SVP | Aug 15, 2016 | Option Exercise | $31.89 | 1,480 | 47,197 | 21,110 | Aug 17, 2016, 04:22 PM |
| BALL KRISTINE M | Chief Financial Officer & SVP | Aug 15, 2016 | Option Exercise | $31.89 | 1,480 | 47,197 | 28,110 | Aug 17, 2016, 04:21 PM |
| Stahl Wilhelm | SVP, Chief Technology Officer | Aug 15, 2016 | Option Exercise | $31.89 | 1,034 | 32,974 | 14,729 | Aug 17, 2016, 04:20 PM |
| Orwin John A | President & CEO | Aug 15, 2016 | Option Exercise | $31.89 | 3,994 | 127,369 | 53,892 | Aug 17, 2016, 04:20 PM |
| DONDERO JAMES D | 10% Owner | Aug 11, 2016 | Sale | $31.96 | 37,000 | 1,182,520 | 128,000 | Aug 15, 2016, 06:21 PM |
| ORBIMED ADVISORS LLC | 10% Owner | Jul 25, 2016 | Sale | $31.98 | 343,600 | 10,988,328 | 3,356,400 | Jul 26, 2016, 06:04 PM |
| ORBIMED ADVISORS LLC | 10% Owner | Jul 22, 2016 | Sale | $32.00 | 3,700,000 | 118,400,000 | 3,700,000 | Jul 26, 2016, 06:04 PM |
| Torley Helen | Director | Jun 07, 2016 | Sale | $19.32 | 1,013 | 19,570 | 1,237 | Jun 08, 2016, 05:23 PM |
| SPIEGELMAN DANIEL K | Director | Jun 07, 2016 | Sale | $19.31 | 1,013 | 19,562 | 1,237 | Jun 08, 2016, 05:22 PM |
| Hillan Kenneth J. | Director | Jun 07, 2016 | Sale | $19.31 | 1,013 | 19,563 | 1,237 | Jun 08, 2016, 05:21 PM |
| Butler John P. | Director | Jun 07, 2016 | Sale | $19.32 | 1,013 | 19,570 | 2,849 | Jun 08, 2016, 05:19 PM |
| HASTINGS PAUL J | Director | Jun 07, 2016 | Sale | $19.32 | 1,013 | 19,573 | 2,495 | Jun 08, 2016, 05:18 PM |
| MCGIRR DAVID W J | Director | Jun 07, 2016 | Sale | $19.34 | 1,013 | 19,588 | 2,729 | Jun 08, 2016, 05:17 PM |
| Krasnow Ronald A. | See Remarks | Jun 03, 2016 | Option Exercise | $19.96 | 548 | 10,938 | 15,763 | Jun 07, 2016, 06:53 PM |
| Stahl Wilhelm | SVP, Chief Technology Officer | Jun 03, 2016 | Option Exercise | $19.96 | 548 | 10,938 | 15,763 | Jun 07, 2016, 06:51 PM |
| Garland J. Scott | SVP & Chief Commercial Officer | Jun 03, 2016 | Option Exercise | $19.96 | 783 | 15,629 | 15,050 | Jun 07, 2016, 06:50 PM |
| Harrison Stephen D | SVP & Chief Scientific Officer | Jun 03, 2016 | Option Exercise | $19.96 | 783 | 15,629 | 18,549 | Jun 07, 2016, 06:49 PM |
| Berman Lance | Chief Medical Officer and SVP | Jun 03, 2016 | Option Exercise | $19.96 | 783 | 15,629 | 22,590 | Jun 07, 2016, 06:48 PM |
| Corbett Mary | Senior VP, Human Resources | Jun 03, 2016 | Option Exercise | $19.96 | 548 | 10,938 | 18,364 | Jun 07, 2016, 06:48 PM |
| Orwin John A | President & CEO | Jun 03, 2016 | Option Exercise | $19.96 | 2,114 | 42,195 | 57,886 | Jun 07, 2016, 06:47 PM |
| BALL KRISTINE M | Chief Financial Officer & SVP | Jun 03, 2016 | Option Exercise | $19.96 | 783 | 15,629 | 29,590 | Jun 07, 2016, 06:46 PM |
| Harrison Stephen D | SVP & Chief Scientific Officer | Feb 29, 2016 | Option Exercise | $11.27 | 2,218 | 24,999 | 17,249 | Mar 16, 2016, 07:29 PM |
| Corbett Mary | Senior VP, Human Resources | Feb 29, 2016 | Option Exercise | $11.27 | 1,274 | 14,359 | 17,454 | Mar 16, 2016, 07:28 PM |
| BALL KRISTINE M | Chief Financial Officer & SVP | Mar 16, 2016 | Buy | $12.15 | 7,000 | 85,050 | 28,290 | Mar 16, 2016, 07:27 PM |
| Schuetz Thomas J. | Director | Mar 15, 2016 | Buy | $13.39 | 30,000 | 401,832 | 33,962 | Mar 16, 2016, 07:26 PM |
| Stahl Wilhelm | SVP, Chief Technology Officer | Dec 31, 2015 | Option Exercise | $3.96 | 20,000 | 79,200 | 34,853 | Jan 04, 2016, 05:27 PM |
| Stahl Wilhelm | SVP, Chief Technology Officer | Dec 31, 2015 | Sale | $28.53 | 20,000 | 570,558 | 14,853 | Jan 04, 2016, 05:27 PM |
| ORBIMED ADVISORS LLC | 10% Owner | Dec 23, 2015 | Sale | $27.18 | 100,000 | 2,717,564 | 7,452,058 | Dec 23, 2015, 05:06 PM |
| ORBIMED ADVISORS LLC | 10% Owner | Dec 22, 2015 | Sale | $26.55 | 150,000 | 3,982,837 | 7,538,630 | Dec 23, 2015, 05:06 PM |
| ORBIMED ADVISORS LLC | 10% Owner | Dec 21, 2015 | Sale | $27.55 | 250,000 | 6,887,612 | 7,664,171 | Dec 23, 2015, 05:06 PM |
| Orwin John A | President & CEO | Dec 07, 2015 | Option Exercise | $7.40 | 10,000 | 74,000 | 69,375 | Dec 09, 2015, 08:24 PM |
| Orwin John A | President & CEO | Dec 07, 2015 | Sale | $28.28 | 15,000 | 424,132 | 62,554 | Dec 09, 2015, 08:24 PM |
| Berman Lance | Chief Medical Officer and SVP | Dec 09, 2015 | Option Exercise | $7.40 | 750 | 5,550 | 22,040 | Dec 09, 2015, 08:23 PM |
| Berman Lance | Chief Medical Officer and SVP | Dec 07, 2015 | Option Exercise | $4.51 | 30,000 | 135,157 | 51,290 | Dec 09, 2015, 08:23 PM |
| Berman Lance | Chief Medical Officer and SVP | Dec 07, 2015 | Sale | $29.78 | 30,000 | 893,400 | 21,290 | Dec 09, 2015, 08:23 PM |
| Berman Lance | Chief Medical Officer and SVP | Dec 09, 2015 | Sale | $29.50 | 750 | 22,125 | 21,290 | Dec 09, 2015, 08:23 PM |
| Orwin John A | President & CEO | Dec 02, 2015 | Option Exercise | $7.40 | 20,000 | 148,000 | 79,375 | Dec 04, 2015, 05:50 PM |
| Orwin John A | President & CEO | Dec 04, 2015 | Option Exercise | $7.40 | 20,000 | 148,000 | 79,375 | Dec 04, 2015, 05:50 PM |
| Orwin John A | President & CEO | Dec 04, 2015 | Sale | $25.00 | 20,000 | 500,000 | 59,375 | Dec 04, 2015, 05:50 PM |
| Orwin John A | President & CEO | Dec 02, 2015 | Sale | $25.00 | 20,000 | 500,000 | 59,375 | Dec 04, 2015, 05:50 PM |
| ORBIMED ADVISORS LLC | 10% Owner | Oct 22, 2015 | Buy | $12.56 | 500,000 | 6,280,165 | 7,900,000 | Oct 22, 2015, 06:00 PM |
| BALL KRISTINE M | Chief Financial Officer & SVP | Sep 02, 2015 | Sale | $22.96 | 646 | 14,832 | 15,040 | Sep 03, 2015, 06:21 PM |
| Krasnow Ronald A. | See Remarks | Aug 17, 2015 | Sale | $24.75 | 522 | 12,922 | 10,478 | Aug 19, 2015, 07:42 PM |
| Corbett Mary | Senior VP, Human Resources | Aug 17, 2015 | Sale | $24.72 | 522 | 12,906 | 10,479 | Aug 19, 2015, 07:41 PM |
| Berman Lance | Chief Medical Officer and SVP | Aug 17, 2015 | Sale | $24.77 | 710 | 17,586 | 15,040 | Aug 19, 2015, 07:41 PM |
| BALL KRISTINE M | Chief Financial Officer & SVP | Aug 17, 2015 | Sale | $24.78 | 710 | 17,597 | 15,040 | Aug 19, 2015, 07:40 PM |
| Orwin John A | President & CEO | Aug 17, 2015 | Sale | $24.84 | 5,000 | 124,183 | 44,866 | Aug 19, 2015, 07:40 PM |
| Stahl Wilhelm | SVP, Chief Technology Officer | Aug 17, 2015 | Sale | $24.70 | 522 | 12,894 | 10,478 | Aug 19, 2015, 07:39 PM |
| Lockey Claire | See Remarks | Aug 17, 2015 | Sale | $24.69 | 522 | 12,888 | 10,478 | Aug 19, 2015, 07:39 PM |
| Orwin John A | President & CEO | Jul 31, 2015 | Option Exercise | $7.40 | 5,000 | 37,000 | 35,000 | Aug 03, 2015, 08:43 PM |
| Orwin John A | President & CEO | Jul 30, 2015 | Option Exercise | $7.40 | 20,000 | 148,000 | 50,000 | Aug 03, 2015, 08:43 PM |
| Orwin John A | President & CEO | Jul 31, 2015 | Sale | $33.52 | 10,000 | 335,225 | 25,200 | Aug 03, 2015, 08:43 PM |
| Orwin John A | President & CEO | Jul 30, 2015 | Sale | $33.58 | 20,000 | 671,573 | 30,200 | Aug 03, 2015, 08:43 PM |
| MCGIRR DAVID W J | Director | Jun 11, 2015 | Sale | $34.67 | 1,220 | 42,300 | 3,742 | Jun 15, 2015, 06:42 PM |
| HASTINGS PAUL J | Director | Jun 11, 2015 | Sale | $34.63 | 1,454 | 50,359 | 3,508 | Jun 15, 2015, 06:41 PM |
| Butler John P. | Director | Jun 11, 2015 | Sale | $34.62 | 1,100 | 38,087 | 3,862 | Jun 15, 2015, 06:40 PM |
| Schuetz Thomas J. | Director | Jun 11, 2015 | Sale | $34.57 | 1,000 | 34,571 | 3,962 | Jun 15, 2015, 06:39 PM |
| Orwin John A | President & CEO | May 29, 2015 | Option Exercise | $7.40 | 20,000 | 148,000 | 55,000 | Jun 02, 2015, 08:24 PM |
| Orwin John A | President & CEO | Jun 01, 2015 | Option Exercise | $7.40 | 8,555 | 63,307 | 43,555 | Jun 02, 2015, 08:24 PM |
| Orwin John A | President & CEO | Jun 01, 2015 | Sale | $36.23 | 13,555 | 491,148 | 35,204 | Jun 02, 2015, 08:24 PM |
| Orwin John A | President & CEO | May 29, 2015 | Sale | $36.55 | 20,000 | 731,001 | 40,306 | Jun 02, 2015, 08:24 PM |
| ORBIMED ADVISORS LLC | 10% Owner | May 18, 2015 | Sale | $34.13 | 1,457,551 | 49,746,217 | 7,400,000 | May 20, 2015, 08:30 PM |
| VEITINGER KLAUS R DR | Director | May 11, 2015 | Option Exercise | $3.96 | 5,834 | 23,103 | 8,546 | May 13, 2015, 07:00 PM |
| VEITINGER KLAUS R DR | Director | May 11, 2015 | Sale | $36.06 | 5,834 | 210,387 | 2,712 | May 13, 2015, 07:00 PM |
| VEITINGER KLAUS R DR | Director | Apr 10, 2015 | Option Exercise | $3.96 | 5,832 | 23,095 | 8,544 | Apr 13, 2015, 06:09 PM |
| VEITINGER KLAUS R DR | Director | Apr 10, 2015 | Sale | $35.35 | 5,832 | 206,179 | 2,712 | Apr 13, 2015, 06:09 PM |
| VEITINGER KLAUS R DR | Director | Mar 10, 2015 | Option Exercise | $4.35 | 5,834 | 25,401 | 8,546 | Mar 12, 2015, 06:21 PM |
| VEITINGER KLAUS R DR | Director | Mar 10, 2015 | Sale | $38.67 | 5,834 | 225,594 | 2,712 | Mar 12, 2015, 06:21 PM |
| Lockey Claire | See Remarks | Mar 04, 2015 | Option Exercise | $4.57 | 10,000 | 45,685 | 15,500 | Mar 06, 2015, 07:19 PM |
| Lockey Claire | See Remarks | Mar 04, 2015 | Sale | $40.00 | 10,000 | 400,000 | 5,500 | Mar 06, 2015, 07:19 PM |
| BALL KRISTINE M | Chief Financial Officer & SVP | Mar 05, 2015 | Option Exercise | $3.96 | 3,000 | 11,880 | 10,500 | Mar 05, 2015, 08:24 PM |
| BALL KRISTINE M | Chief Financial Officer & SVP | Mar 03, 2015 | Sale | $38.80 | 519 | 20,137 | 7,500 | Mar 05, 2015, 08:24 PM |
| BALL KRISTINE M | Chief Financial Officer & SVP | Mar 05, 2015 | Sale | $41.00 | 3,000 | 123,000 | 7,500 | Mar 05, 2015, 08:24 PM |
| Krasnow Ronald A. | See Remarks | Feb 27, 2015 | Sale | $39.00 | 348 | 13,572 | 5,500 | Feb 27, 2015, 08:55 PM |
| Krasnow Ronald A. | See Remarks | Feb 26, 2015 | Sale | $39.00 | 5,000 | 195,000 | 5,848 | Feb 27, 2015, 08:55 PM |
| Krasnow Ronald A. | See Remarks | Feb 25, 2015 | Sale | $39.00 | 5,000 | 195,000 | 10,848 | Feb 27, 2015, 08:55 PM |
| Berman Lance | Chief Medical Officer and SVP | Feb 24, 2015 | Option Exercise | $5.23 | 5,000 | 26,130 | 12,500 | Feb 25, 2015, 06:33 PM |
| Berman Lance | Chief Medical Officer and SVP | Feb 24, 2015 | Sale | $38.19 | 5,000 | 190,949 | 9,800 | Feb 25, 2015, 06:33 PM |
| Krasnow Ronald A. | See Remarks | Feb 24, 2015 | Sale | $39.00 | 5,000 | 195,000 | 15,848 | Feb 25, 2015, 11:44 AM |
| Krasnow Ronald A. | See Remarks | Feb 23, 2015 | Sale | $39.00 | 5,000 | 195,000 | 20,848 | Feb 25, 2015, 11:44 AM |
| VEITINGER KLAUS R DR | Director | Feb 10, 2015 | Option Exercise | $4.65 | 5,834 | 27,128 | 8,546 | Feb 10, 2015, 09:06 PM |
| VEITINGER KLAUS R DR | Director | Feb 10, 2015 | Sale | $32.12 | 5,834 | 187,359 | 2,812 | Feb 10, 2015, 09:06 PM |
| Krasnow Ronald A. | See Remarks | Jan 21, 2015 | Option Exercise | $3.78 | 55,000 | 208,103 | 80,848 | Jan 23, 2015, 09:45 PM |
| Krasnow Ronald A. | See Remarks | Jan 21, 2015 | Sale | $35.00 | 55,000 | 1,925,000 | 25,848 | Jan 23, 2015, 09:45 PM |
| BALL KRISTINE M | Chief Financial Officer & SVP | Jan 21, 2015 | Option Exercise | $3.96 | 3,000 | 11,880 | 10,500 | Jan 23, 2015, 09:44 PM |
| BALL KRISTINE M | Chief Financial Officer & SVP | Jan 21, 2015 | Sale | $36.00 | 3,000 | 108,000 | 7,500 | Jan 23, 2015, 09:44 PM |
| Lockey Claire | See Remarks | Jan 21, 2015 | Option Exercise | $4.65 | 5,000 | 23,250 | 10,500 | Jan 23, 2015, 09:43 PM |
| Lockey Claire | See Remarks | Jan 21, 2015 | Sale | $35.00 | 5,000 | 175,000 | 5,500 | Jan 23, 2015, 09:43 PM |
| Krasnow Ronald A. | See Remarks | Jan 14, 2015 | Option Exercise | $2.76 | 5,000 | 13,800 | 30,848 | Jan 16, 2015, 07:43 PM |
| Krasnow Ronald A. | See Remarks | Jan 14, 2015 | Sale | $33.58 | 5,000 | 167,895 | 26,928 | Jan 16, 2015, 07:43 PM |
| VEITINGER KLAUS R DR | Director | Jan 12, 2015 | Option Exercise | $4.65 | 5,834 | 27,128 | 8,546 | Jan 14, 2015, 11:15 AM |
| VEITINGER KLAUS R DR | Director | Jan 12, 2015 | Sale | $32.33 | 5,834 | 188,589 | 4,160 | Jan 14, 2015, 11:15 AM |
| VEITINGER KLAUS R DR | Director | Dec 10, 2014 | Option Exercise | $4.65 | 4,167 | 19,377 | 6,879 | Dec 12, 2014, 07:11 PM |
| VEITINGER KLAUS R DR | Director | Dec 12, 2014 | Option Exercise | $4.65 | 9,852 | 45,812 | 12,564 | Dec 12, 2014, 07:11 PM |
| VEITINGER KLAUS R DR | Director | Dec 11, 2014 | Option Exercise | $4.65 | 150 | 698 | 2,862 | Dec 12, 2014, 07:11 PM |
| VEITINGER KLAUS R DR | Director | Dec 10, 2014 | Sale | $31.35 | 4,167 | 130,617 | 6,079 | Dec 12, 2014, 07:11 PM |
| VEITINGER KLAUS R DR | Director | Dec 12, 2014 | Sale | $32.50 | 9,852 | 320,190 | 2,712 | Dec 12, 2014, 07:11 PM |
| VEITINGER KLAUS R DR | Director | Dec 11, 2014 | Sale | $32.50 | 150 | 4,875 | 2,712 | Dec 12, 2014, 07:11 PM |
| 5AM Partners III, LLC | 10% Owner | Dec 09, 2014 | Sale | $30.04 | 589,637 | 17,712,696 | 1,843,243 | Dec 11, 2014, 04:55 PM |
| Lockey Claire | See Remarks | Dec 09, 2014 | Option Exercise | $4.65 | 8,000 | 37,200 | 13,500 | Dec 10, 2014, 08:29 PM |
| Lockey Claire | See Remarks | Dec 09, 2014 | Sale | $30.00 | 8,000 | 240,000 | 5,500 | Dec 10, 2014, 08:29 PM |
| Berman Lance | Chief Medical Officer and SVP | Nov 28, 2014 | Option Exercise | $4.50 | 5,000 | 22,504 | 12,500 | Dec 02, 2014, 07:02 PM |
| Berman Lance | Chief Medical Officer and SVP | Nov 28, 2014 | Sale | $25.00 | 5,000 | 125,000 | 7,500 | Dec 02, 2014, 07:02 PM |
| Berman Lance | Chief Medical Officer and SVP | Nov 25, 2014 | Option Exercise | $4.56 | 15,000 | 68,399 | 22,500 | Nov 26, 2014, 04:33 PM |
| Berman Lance | Chief Medical Officer and SVP | Nov 24, 2014 | Option Exercise | $3.96 | 15,000 | 59,400 | 22,500 | Nov 26, 2014, 04:33 PM |
| Berman Lance | Chief Medical Officer and SVP | Nov 24, 2014 | Sale | $25.00 | 15,000 | 375,000 | 7,500 | Nov 26, 2014, 04:33 PM |
| Berman Lance | Chief Medical Officer and SVP | Nov 25, 2014 | Sale | $25.00 | 15,000 | 375,000 | 7,500 | Nov 26, 2014, 04:33 PM |
| VEITINGER KLAUS R DR | Director | Nov 20, 2014 | Option Exercise | $4.65 | 3,334 | 15,503 | 6,046 | Nov 24, 2014, 05:48 PM |
| VEITINGER KLAUS R DR | Director | Nov 20, 2014 | Sale | $22.50 | 3,334 | 75,015 | 2,712 | Nov 24, 2014, 05:48 PM |
| VEITINGER KLAUS R DR | Director | Nov 10, 2014 | Option Exercise | $4.65 | 2,500 | 11,625 | 5,212 | Nov 12, 2014, 04:29 PM |
| VEITINGER KLAUS R DR | Director | Nov 10, 2014 | Sale | $20.06 | 2,500 | 50,144 | 2,712 | Nov 12, 2014, 04:29 PM |
| VEITINGER KLAUS R DR | Director | Oct 10, 2014 | Option Exercise | $4.65 | 2,500 | 11,625 | 5,212 | Oct 15, 2014, 04:19 PM |
| VEITINGER KLAUS R DR | Director | Oct 10, 2014 | Sale | $19.34 | 2,500 | 48,343 | 2,812 | Oct 15, 2014, 04:19 PM |
| Berman Lance | Chief Medical Officer and SVP | Sep 24, 2014 | Option Exercise | $4.41 | 5,000 | 22,033 | 12,500 | Sep 25, 2014, 08:01 PM |
| Berman Lance | Chief Medical Officer and SVP | Sep 24, 2014 | Sale | $22.00 | 5,000 | 110,000 | 7,500 | Sep 25, 2014, 08:01 PM |
| ORBIMED ADVISORS LLC | 10% Owner | Sep 17, 2014 | Sale | $25.07 | 49,000 | 1,228,430 | 8,857,551 | Sep 18, 2014, 05:20 PM |
| ORBIMED ADVISORS LLC | 10% Owner | Sep 16, 2014 | Sale | $25.49 | 45,000 | 1,146,836 | 8,909,151 | Sep 18, 2014, 05:20 PM |
| 5AM Partners II, LLC | 10% Owner | Sep 16, 2014 | Sale | $26.03 | 612,540 | 15,944,417 | 1,269,398 | Sep 17, 2014, 02:48 PM |
| VEITINGER KLAUS R DR | Director | Sep 10, 2014 | Option Exercise | $4.65 | 4,167 | 19,377 | 6,879 | Sep 11, 2014, 07:38 PM |
| VEITINGER KLAUS R DR | Director | Sep 10, 2014 | Sale | $23.00 | 4,167 | 95,851 | 2,712 | Sep 11, 2014, 07:38 PM |
| Stahl Wilhelm | SVP, Pharmaceutical Operations | Aug 29, 2014 | Option Exercise | $4.21 | 15,785 | 66,520 | 21,285 | Sep 03, 2014, 05:56 PM |
| Stahl Wilhelm | SVP, Pharmaceutical Operations | Aug 29, 2014 | Sale | $25.29 | 15,785 | 399,253 | 5,500 | Sep 03, 2014, 05:56 PM |
| 5AM Partners II, LLC | 10% Owner | Aug 26, 2014 | Sale | $26.53 | 96,310 | 2,555,104 | 1,858,686 | Aug 27, 2014, 04:49 PM |
| 5AM Partners II, LLC | 10% Owner | Aug 25, 2014 | Sale | $26.50 | 336,690 | 8,922,285 | 1,951,340 | Aug 27, 2014, 04:49 PM |
| Berman Lance | Chief Medical Officer and SVP | Aug 25, 2014 | Option Exercise | $7.40 | 5,000 | 37,000 | 12,500 | Aug 26, 2014, 07:52 PM |
| Berman Lance | Chief Medical Officer and SVP | Aug 22, 2014 | Option Exercise | $4.37 | 15,000 | 65,568 | 22,500 | Aug 26, 2014, 07:52 PM |
| Berman Lance | Chief Medical Officer and SVP | Aug 25, 2014 | Sale | $26.48 | 5,000 | 132,379 | 7,500 | Aug 26, 2014, 07:52 PM |
| Berman Lance | Chief Medical Officer and SVP | Aug 22, 2014 | Sale | $25.69 | 15,000 | 385,343 | 7,500 | Aug 26, 2014, 07:52 PM |
| ORBIMED ADVISORS LLC | 10% Owner | Aug 15, 2014 | Sale | $26.35 | 990,000 | 26,086,500 | 8,951,551 | Aug 19, 2014, 08:22 PM |
| VEITINGER KLAUS R DR | Director | Aug 11, 2014 | Option Exercise | $4.65 | 4,167 | 19,377 | 6,879 | Aug 12, 2014, 07:17 PM |
| VEITINGER KLAUS R DR | Director | Aug 11, 2014 | Sale | $27.73 | 4,167 | 115,563 | 2,712 | Aug 12, 2014, 07:17 PM |
| Stahl Wilhelm | SVP, Pharmaceutical Operations | Aug 08, 2014 | Option Exercise | $3.96 | 49,300 | 195,228 | 49,300 | Aug 12, 2014, 07:16 PM |
| Stahl Wilhelm | SVP, Pharmaceutical Operations | Aug 08, 2014 | Sale | $25.09 | 49,300 | 1,237,085 | 0 | Aug 12, 2014, 07:16 PM |
| Lockey Claire | See Remarks | Aug 08, 2014 | Option Exercise | $4.65 | 10,000 | 46,500 | 10,000 | Aug 12, 2014, 07:16 PM |
| Lockey Claire | See Remarks | Aug 08, 2014 | Sale | $26.50 | 10,000 | 265,000 | 6,000 | Aug 12, 2014, 07:16 PM |
| Berman Lance | Chief Medical Officer and SVP | Jul 22, 2014 | Option Exercise | $3.96 | 15,000 | 59,400 | 15,000 | Jul 24, 2014, 07:12 PM |
| Berman Lance | Chief Medical Officer and SVP | Jul 24, 2014 | Option Exercise | $3.96 | 15,000 | 59,400 | 15,000 | Jul 24, 2014, 07:12 PM |
| Berman Lance | Chief Medical Officer and SVP | Jul 23, 2014 | Option Exercise | $3.96 | 15,000 | 59,400 | 15,000 | Jul 24, 2014, 07:12 PM |
| Berman Lance | Chief Medical Officer and SVP | Jul 22, 2014 | Sale | $23.67 | 15,000 | 354,993 | 0 | Jul 24, 2014, 07:12 PM |
| Berman Lance | Chief Medical Officer and SVP | Jul 24, 2014 | Sale | $23.86 | 15,000 | 357,896 | 1,472 | Jul 24, 2014, 07:12 PM |
| Berman Lance | Chief Medical Officer and SVP | Jul 23, 2014 | Sale | $24.24 | 15,000 | 363,622 | 400 | Jul 24, 2014, 07:12 PM |
| VEITINGER KLAUS R DR | Director | Jul 10, 2014 | Option Exercise | $4.65 | 4,167 | 19,377 | 6,879 | Jul 11, 2014, 06:23 PM |
| VEITINGER KLAUS R DR | Director | Jul 10, 2014 | Sale | $23.12 | 4,167 | 96,354 | 2,712 | Jul 11, 2014, 06:23 PM |
| New Leaf Ventures I, L.P. | Director | Nov 20, 2013 | Option Exercise | $11.00 | 21,691 | 238,601 | 1,928,912 | Nov 20, 2013, 09:51 PM |
| New Leaf Ventures I, L.P. | Director | Nov 20, 2013 | Option Exercise | $9.18 | 25,977 | 238,594 | 1,950,603 | Nov 20, 2013, 09:51 PM |
| New Leaf Ventures I, L.P. | Director | Nov 20, 2013 | Buy | $11.00 | 185,978 | 2,045,758 | 2,114,890 | Nov 20, 2013, 09:51 PM |
| HUNT RONALD | Director | Nov 20, 2013 | Option Exercise | $11.00 | 21,691 | 238,601 | 1,928,912 | Nov 20, 2013, 09:50 PM |
| HUNT RONALD | Director | Nov 20, 2013 | Option Exercise | $9.18 | 25,977 | 238,594 | 1,950,603 | Nov 20, 2013, 09:50 PM |
| HUNT RONALD | Director | Nov 20, 2013 | Buy | $11.00 | 185,978 | 2,045,758 | 2,114,890 | Nov 20, 2013, 09:50 PM |
| SILVERSTEIN JONATHAN | Director | Nov 20, 2013 | Option Exercise | $11.00 | 27,282 | 300,102 | 9,229,359 | Nov 20, 2013, 07:31 PM |
| SILVERSTEIN JONATHAN | Director | Nov 20, 2013 | Option Exercise | $0.17 | 1,744,711 | 296,601 | 9,234,475 | Nov 20, 2013, 07:31 PM |
| SILVERSTEIN JONATHAN | Director | Nov 20, 2013 | Buy | $11.00 | 712,192 | 7,834,112 | 9,941,551 | Nov 20, 2013, 07:31 PM |
| ORBIMED ADVISORS LLC | 10% Owner | Nov 20, 2013 | Option Exercise | $11.00 | 27,282 | 300,102 | 9,229,359 | Nov 20, 2013, 07:23 PM |
| ORBIMED ADVISORS LLC | 10% Owner | Nov 20, 2013 | Option Exercise | $0.17 | 1,744,711 | 296,601 | 9,234,475 | Nov 20, 2013, 07:23 PM |
| ORBIMED ADVISORS LLC | 10% Owner | Nov 20, 2013 | Buy | $11.00 | 712,192 | 7,834,112 | 9,941,551 | Nov 20, 2013, 07:23 PM |
| ROCKLAGE SCOTT M | Director | Nov 20, 2013 | Option Exercise | $11.00 | 221 | 2,431 | 52,952 | Nov 20, 2013, 07:18 PM |
| ROCKLAGE SCOTT M | Director | Nov 20, 2013 | Option Exercise | $0.17 | 14,024 | 2,384 | 52,994 | Nov 20, 2013, 07:18 PM |
| ROCKLAGE SCOTT M | Director | Nov 20, 2013 | Buy | $11.00 | 9,364 | 103,004 | 62,316 | Nov 20, 2013, 07:18 PM |
| ROCKLAGE SCOTT M | Director | Nov 20, 2013 | Option Exercise | $11.00 | 42,160 | 463,760 | 2,275,248 | Nov 20, 2013, 07:13 PM |
| ROCKLAGE SCOTT M | Director | Nov 20, 2013 | Option Exercise | $0.68 | 677,742 | 462,439 | 2,275,517 | Nov 20, 2013, 07:13 PM |
| ROCKLAGE SCOTT M | Director | Nov 20, 2013 | Buy | $11.00 | 363,328 | 3,996,608 | 2,418,066 | Nov 20, 2013, 07:13 PM |
| 5AM Partners III, LLC | 10% Owner | Nov 20, 2013 | Option Exercise | $11.00 | 8,731 | 96,041 | 2,054,738 | Nov 20, 2013, 07:13 PM |
| 5AM Partners III, LLC | 10% Owner | Nov 20, 2013 | Option Exercise | $0.17 | 558,220 | 94,897 | 2,056,334 | Nov 20, 2013, 07:13 PM |
| 5AM Partners III, LLC | 10% Owner | Nov 20, 2013 | Buy | $11.00 | 372,692 | 4,099,612 | 2,418,066 | Nov 20, 2013, 07:13 PM |
| Orwin John A | President & CEO | Nov 20, 2013 | Buy | $11.00 | 15,000 | 165,000 | 15,000 | Nov 20, 2013, 07:10 PM |
| 5AM Partners II, LLC | 10% Owner | Nov 20, 2013 | Option Exercise | $11.00 | 33,650 | 370,150 | 2,275,248 | Nov 20, 2013, 05:45 PM |
| 5AM Partners II, LLC | 10% Owner | Nov 20, 2013 | Option Exercise | $2.77 | 133,546 | 369,926 | 2,275,517 | Nov 20, 2013, 05:45 PM |
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Buy
Sale
Option Exercise
| Owner | Relationship | Date | Value($) |
| Torley Helen | Director | 09/01/2016 | 72,000 |
| Torley Helen | Director | 09/01/2016 | 39,584 |
| SPIEGELMAN DANIEL K | Director | 09/01/2016 | 72,000 |
| SPIEGELMAN DANIEL K | Director | 09/01/2016 | 39,584 |
| Schuetz Thomas J. | Director | 09/01/2016 | 72,000 |
| Schuetz Thomas J. | Director | 09/01/2016 | 1,086,784 |
| MCGIRR DAVID W J | Director | 09/01/2016 | 72,000 |
| MCGIRR DAVID W J | Director | 09/01/2016 | 87,328 |
| Hillan Kenneth J. | Director | 09/01/2016 | 72,000 |
| Hillan Kenneth J. | Director | 09/01/2016 | 39,584 |
| HASTINGS PAUL J | Director | 09/01/2016 | 72,000 |
| HASTINGS PAUL J | Director | 09/01/2016 | 79,840 |
| Butler John P. | Director | 09/01/2016 | 72,000 |
| Butler John P. | Director | 09/01/2016 | 91,168 |
| Stahl Wilhelm | SVP, Chief Technology Officer | 09/01/2016 | 453,344 |
| Stahl Wilhelm | SVP, Chief Technology Officer | 09/01/2016 | 111,328 |
| Orwin John A | President & CEO | 09/01/2016 | 1,760,000 |
| Orwin John A | President & CEO | 09/01/2016 | 324,544 |
| Montgomery Monte | Chief Accounting Officer | 09/01/2016 | 422,400 |
| Montgomery Monte | Chief Accounting Officer | 09/01/2016 | 66,112 |
| Krasnow Ronald A. | See Remarks | 09/01/2016 | 453,344 |
| Krasnow Ronald A. | See Remarks | 09/01/2016 | 111,328 |
| Harrison Stephen D | SVP & Chief Scientific Officer | 09/01/2016 | 513,344 |
| Harrison Stephen D | SVP & Chief Scientific Officer | 09/01/2016 | 191,008 |
| Garland J. Scott | SVP & Chief Commercial Officer | 09/01/2016 | 513,344 |
| Garland J. Scott | SVP & Chief Commercial Officer | 09/01/2016 | 79,040 |
| Corbett Mary | Senior VP, Human Resources | 09/01/2016 | 453,344 |
| Corbett Mary | Senior VP, Human Resources | 09/01/2016 | 194,560 |
| Berman Lance | Chief Medical Officer and SVP | 09/01/2016 | 651,360 |
| Berman Lance | Chief Medical Officer and SVP | 09/01/2016 | 157,504 |
| BALL KRISTINE M | Chief Financial Officer & SVP | 09/01/2016 | 651,360 |
| BALL KRISTINE M | Chief Financial Officer & SVP | 09/01/2016 | 381,504 |
| Montgomery Monte | Chief Accounting Officer | 08/16/2016 | 16,279 |
| DONDERO JAMES D | 10% Owner | 08/17/2016 | 15,960 |
| Krasnow Ronald A. | See Remarks | 08/15/2016 | 32,974 |
| Harrison Stephen D | SVP & Chief Scientific Officer | 08/15/2016 | 22,482 |
| Garland J. Scott | SVP & Chief Commercial Officer | 08/15/2016 | 22,482 |
| Corbett Mary | Senior VP, Human Resources | 08/15/2016 | 32,974 |
| Berman Lance | Chief Medical Officer and SVP | 08/15/2016 | 47,197 |
| BALL KRISTINE M | Chief Financial Officer & SVP | 08/15/2016 | 47,197 |
| Stahl Wilhelm | SVP, Chief Technology Officer | 08/15/2016 | 32,974 |
| Orwin John A | President & CEO | 08/15/2016 | 127,369 |
| DONDERO JAMES D | 10% Owner | 08/11/2016 | 1,182,520 |
| ORBIMED ADVISORS LLC | 10% Owner | 07/25/2016 | 10,988,328 |
| ORBIMED ADVISORS LLC | 10% Owner | 07/22/2016 | 118,400,000 |
| Torley Helen | Director | 06/07/2016 | 19,570 |
| SPIEGELMAN DANIEL K | Director | 06/07/2016 | 19,562 |
| Hillan Kenneth J. | Director | 06/07/2016 | 19,563 |
| Butler John P. | Director | 06/07/2016 | 19,570 |
| HASTINGS PAUL J | Director | 06/07/2016 | 19,573 |
| MCGIRR DAVID W J | Director | 06/07/2016 | 19,588 |
| Krasnow Ronald A. | See Remarks | 06/03/2016 | 10,938 |
| Stahl Wilhelm | SVP, Chief Technology Officer | 06/03/2016 | 10,938 |
| Garland J. Scott | SVP & Chief Commercial Officer | 06/03/2016 | 15,629 |
| Harrison Stephen D | SVP & Chief Scientific Officer | 06/03/2016 | 15,629 |
| Berman Lance | Chief Medical Officer and SVP | 06/03/2016 | 15,629 |
| Corbett Mary | Senior VP, Human Resources | 06/03/2016 | 10,938 |
| Orwin John A | President & CEO | 06/03/2016 | 42,195 |
| BALL KRISTINE M | Chief Financial Officer & SVP | 06/03/2016 | 15,629 |
| Harrison Stephen D | SVP & Chief Scientific Officer | 02/29/2016 | 24,999 |
| Corbett Mary | Senior VP, Human Resources | 02/29/2016 | 14,359 |
| BALL KRISTINE M | Chief Financial Officer & SVP | 03/16/2016 | 85,050 |
| Schuetz Thomas J. | Director | 03/15/2016 | 401,832 |
| Stahl Wilhelm | SVP, Chief Technology Officer | 12/31/2015 | 79,200 |
| Stahl Wilhelm | SVP, Chief Technology Officer | 12/31/2015 | 570,558 |
| ORBIMED ADVISORS LLC | 10% Owner | 12/23/2015 | 2,717,564 |
| ORBIMED ADVISORS LLC | 10% Owner | 12/22/2015 | 3,982,837 |
| ORBIMED ADVISORS LLC | 10% Owner | 12/21/2015 | 6,887,612 |
| Orwin John A | President & CEO | 12/07/2015 | 74,000 |
| Orwin John A | President & CEO | 12/07/2015 | 424,132 |
| Berman Lance | Chief Medical Officer and SVP | 12/09/2015 | 5,550 |
| Berman Lance | Chief Medical Officer and SVP | 12/07/2015 | 135,157 |
| Berman Lance | Chief Medical Officer and SVP | 12/07/2015 | 893,400 |
| Berman Lance | Chief Medical Officer and SVP | 12/09/2015 | 22,125 |
| Orwin John A | President & CEO | 12/02/2015 | 148,000 |
| Orwin John A | President & CEO | 12/04/2015 | 148,000 |
| Orwin John A | President & CEO | 12/04/2015 | 500,000 |
| Orwin John A | President & CEO | 12/02/2015 | 500,000 |
| ORBIMED ADVISORS LLC | 10% Owner | 10/22/2015 | 6,280,165 |
| BALL KRISTINE M | Chief Financial Officer & SVP | 09/02/2015 | 14,832 |
| Krasnow Ronald A. | See Remarks | 08/17/2015 | 12,922 |
| Corbett Mary | Senior VP, Human Resources | 08/17/2015 | 12,906 |
| Berman Lance | Chief Medical Officer and SVP | 08/17/2015 | 17,586 |
| BALL KRISTINE M | Chief Financial Officer & SVP | 08/17/2015 | 17,597 |
| Orwin John A | President & CEO | 08/17/2015 | 124,183 |
| Stahl Wilhelm | SVP, Chief Technology Officer | 08/17/2015 | 12,894 |
| Lockey Claire | See Remarks | 08/17/2015 | 12,888 |
| Orwin John A | President & CEO | 07/31/2015 | 37,000 |
| Orwin John A | President & CEO | 07/30/2015 | 148,000 |
| Orwin John A | President & CEO | 07/31/2015 | 335,225 |
| Orwin John A | President & CEO | 07/30/2015 | 671,573 |
| MCGIRR DAVID W J | Director | 06/11/2015 | 42,300 |
| HASTINGS PAUL J | Director | 06/11/2015 | 50,359 |
| Butler John P. | Director | 06/11/2015 | 38,087 |
| Schuetz Thomas J. | Director | 06/11/2015 | 34,571 |
| Orwin John A | President & CEO | 05/29/2015 | 148,000 |
| Orwin John A | President & CEO | 06/01/2015 | 63,307 |
| Orwin John A | President & CEO | 06/01/2015 | 491,148 |
| Orwin John A | President & CEO | 05/29/2015 | 731,001 |
| ORBIMED ADVISORS LLC | 10% Owner | 05/18/2015 | 49,746,217 |
| VEITINGER KLAUS R DR | Director | 05/11/2015 | 23,103 |
| VEITINGER KLAUS R DR | Director | 05/11/2015 | 210,387 |
| VEITINGER KLAUS R DR | Director | 04/10/2015 | 23,095 |
| VEITINGER KLAUS R DR | Director | 04/10/2015 | 206,179 |
| VEITINGER KLAUS R DR | Director | 03/10/2015 | 25,401 |
| VEITINGER KLAUS R DR | Director | 03/10/2015 | 225,594 |
| Lockey Claire | See Remarks | 03/04/2015 | 45,685 |
| Lockey Claire | See Remarks | 03/04/2015 | 400,000 |
| BALL KRISTINE M | Chief Financial Officer & SVP | 03/05/2015 | 11,880 |
| BALL KRISTINE M | Chief Financial Officer & SVP | 03/03/2015 | 20,137 |
| BALL KRISTINE M | Chief Financial Officer & SVP | 03/05/2015 | 123,000 |
| Krasnow Ronald A. | See Remarks | 02/27/2015 | 13,572 |
| Krasnow Ronald A. | See Remarks | 02/26/2015 | 195,000 |
| Krasnow Ronald A. | See Remarks | 02/25/2015 | 195,000 |
| Berman Lance | Chief Medical Officer and SVP | 02/24/2015 | 26,130 |
| Berman Lance | Chief Medical Officer and SVP | 02/24/2015 | 190,949 |
| Krasnow Ronald A. | See Remarks | 02/24/2015 | 195,000 |
| Krasnow Ronald A. | See Remarks | 02/23/2015 | 195,000 |
| VEITINGER KLAUS R DR | Director | 02/10/2015 | 27,128 |
| VEITINGER KLAUS R DR | Director | 02/10/2015 | 187,359 |
| Krasnow Ronald A. | See Remarks | 01/21/2015 | 208,103 |
| Krasnow Ronald A. | See Remarks | 01/21/2015 | 1,925,000 |
| BALL KRISTINE M | Chief Financial Officer & SVP | 01/21/2015 | 11,880 |
| BALL KRISTINE M | Chief Financial Officer & SVP | 01/21/2015 | 108,000 |
| Lockey Claire | See Remarks | 01/21/2015 | 23,250 |
| Lockey Claire | See Remarks | 01/21/2015 | 175,000 |
| Krasnow Ronald A. | See Remarks | 01/14/2015 | 13,800 |
| Krasnow Ronald A. | See Remarks | 01/14/2015 | 167,895 |
| VEITINGER KLAUS R DR | Director | 01/12/2015 | 27,128 |
| VEITINGER KLAUS R DR | Director | 01/12/2015 | 188,589 |
| VEITINGER KLAUS R DR | Director | 12/10/2014 | 19,377 |
| VEITINGER KLAUS R DR | Director | 12/12/2014 | 45,812 |
| VEITINGER KLAUS R DR | Director | 12/11/2014 | 698 |
| VEITINGER KLAUS R DR | Director | 12/10/2014 | 130,617 |
| VEITINGER KLAUS R DR | Director | 12/12/2014 | 320,190 |
| VEITINGER KLAUS R DR | Director | 12/11/2014 | 4,875 |
| 5AM Partners III, LLC | 10% Owner | 12/09/2014 | 17,712,696 |
| Lockey Claire | See Remarks | 12/09/2014 | 37,200 |
| Lockey Claire | See Remarks | 12/09/2014 | 240,000 |
| Berman Lance | Chief Medical Officer and SVP | 11/28/2014 | 22,504 |
| Berman Lance | Chief Medical Officer and SVP | 11/28/2014 | 125,000 |
| Berman Lance | Chief Medical Officer and SVP | 11/25/2014 | 68,399 |
| Berman Lance | Chief Medical Officer and SVP | 11/24/2014 | 59,400 |
| Berman Lance | Chief Medical Officer and SVP | 11/24/2014 | 375,000 |
| Berman Lance | Chief Medical Officer and SVP | 11/25/2014 | 375,000 |
| VEITINGER KLAUS R DR | Director | 11/20/2014 | 15,503 |
| VEITINGER KLAUS R DR | Director | 11/20/2014 | 75,015 |
| VEITINGER KLAUS R DR | Director | 11/10/2014 | 11,625 |
| VEITINGER KLAUS R DR | Director | 11/10/2014 | 50,144 |
| VEITINGER KLAUS R DR | Director | 10/10/2014 | 11,625 |
| VEITINGER KLAUS R DR | Director | 10/10/2014 | 48,343 |
| Berman Lance | Chief Medical Officer and SVP | 09/24/2014 | 22,033 |
| Berman Lance | Chief Medical Officer and SVP | 09/24/2014 | 110,000 |
| ORBIMED ADVISORS LLC | 10% Owner | 09/17/2014 | 1,228,430 |
| ORBIMED ADVISORS LLC | 10% Owner | 09/16/2014 | 1,146,836 |
| 5AM Partners II, LLC | 10% Owner | 09/16/2014 | 15,944,417 |
| VEITINGER KLAUS R DR | Director | 09/10/2014 | 19,377 |
| VEITINGER KLAUS R DR | Director | 09/10/2014 | 95,851 |
| Stahl Wilhelm | SVP, Pharmaceutical Operations | 08/29/2014 | 66,520 |
| Stahl Wilhelm | SVP, Pharmaceutical Operations | 08/29/2014 | 399,253 |
| 5AM Partners II, LLC | 10% Owner | 08/26/2014 | 2,555,104 |
| 5AM Partners II, LLC | 10% Owner | 08/25/2014 | 8,922,285 |
| Berman Lance | Chief Medical Officer and SVP | 08/25/2014 | 37,000 |
| Berman Lance | Chief Medical Officer and SVP | 08/22/2014 | 65,568 |
| Berman Lance | Chief Medical Officer and SVP | 08/25/2014 | 132,379 |
| Berman Lance | Chief Medical Officer and SVP | 08/22/2014 | 385,343 |
| ORBIMED ADVISORS LLC | 10% Owner | 08/15/2014 | 26,086,500 |
| VEITINGER KLAUS R DR | Director | 08/11/2014 | 19,377 |
| VEITINGER KLAUS R DR | Director | 08/11/2014 | 115,563 |
| Stahl Wilhelm | SVP, Pharmaceutical Operations | 08/08/2014 | 195,228 |
| Stahl Wilhelm | SVP, Pharmaceutical Operations | 08/08/2014 | 1,237,085 |
| Lockey Claire | See Remarks | 08/08/2014 | 46,500 |
| Lockey Claire | See Remarks | 08/08/2014 | 265,000 |
| Berman Lance | Chief Medical Officer and SVP | 07/22/2014 | 59,400 |
| Berman Lance | Chief Medical Officer and SVP | 07/24/2014 | 59,400 |
| Berman Lance | Chief Medical Officer and SVP | 07/23/2014 | 59,400 |
| Berman Lance | Chief Medical Officer and SVP | 07/22/2014 | 354,993 |
| Berman Lance | Chief Medical Officer and SVP | 07/24/2014 | 357,896 |
| Berman Lance | Chief Medical Officer and SVP | 07/23/2014 | 363,622 |
| VEITINGER KLAUS R DR | Director | 07/10/2014 | 19,377 |
| VEITINGER KLAUS R DR | Director | 07/10/2014 | 96,354 |
| New Leaf Ventures I, L.P. | Director | 11/20/2013 | 238,601 |
| New Leaf Ventures I, L.P. | Director | 11/20/2013 | 238,594 |
| New Leaf Ventures I, L.P. | Director | 11/20/2013 | 2,045,758 |
| HUNT RONALD | Director | 11/20/2013 | 238,601 |
| HUNT RONALD | Director | 11/20/2013 | 238,594 |
| HUNT RONALD | Director | 11/20/2013 | 2,045,758 |
| SILVERSTEIN JONATHAN | Director | 11/20/2013 | 300,102 |
| SILVERSTEIN JONATHAN | Director | 11/20/2013 | 296,601 |
| SILVERSTEIN JONATHAN | Director | 11/20/2013 | 7,834,112 |
| ORBIMED ADVISORS LLC | 10% Owner | 11/20/2013 | 300,102 |
| ORBIMED ADVISORS LLC | 10% Owner | 11/20/2013 | 296,601 |
| ORBIMED ADVISORS LLC | 10% Owner | 11/20/2013 | 7,834,112 |
| ROCKLAGE SCOTT M | Director | 11/20/2013 | 2,431 |
| ROCKLAGE SCOTT M | Director | 11/20/2013 | 2,384 |
| ROCKLAGE SCOTT M | Director | 11/20/2013 | 103,004 |
| ROCKLAGE SCOTT M | Director | 11/20/2013 | 463,760 |
| ROCKLAGE SCOTT M | Director | 11/20/2013 | 462,439 |
| ROCKLAGE SCOTT M | Director | 11/20/2013 | 3,996,608 |
| 5AM Partners III, LLC | 10% Owner | 11/20/2013 | 96,041 |
| 5AM Partners III, LLC | 10% Owner | 11/20/2013 | 94,897 |
| 5AM Partners III, LLC | 10% Owner | 11/20/2013 | 4,099,612 |
| Orwin John A | President & CEO | 11/20/2013 | 165,000 |
| 5AM Partners II, LLC | 10% Owner | 11/20/2013 | 370,150 |
| 5AM Partners II, LLC | 10% Owner | 11/20/2013 | 369,926 |
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