. (LPTN)
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As of 12/31/69 07:00 PM EST. Market closed.
. (LPTN)
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INSIDER TRANSACTIONS FOR
| Owner | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| McGaughy R Kent Jr | Director | Dec 28, 2022 | Option Exercise | $3.25 | 1,465,770 | 4,763,753 | 3,687,781 | Dec 30, 2022, 05:25 PM |
| McGaughy R Kent Jr | Director | Dec 28, 2022 | Option Exercise | $3.25 | 586,308 | 1,905,501 | 1,310,701 | Dec 30, 2022, 05:25 PM |
| McGaughy R Kent Jr | Director | Dec 28, 2022 | Option Exercise | $3.25 | 146,577 | 476,375 | 675,181 | Dec 30, 2022, 05:25 PM |
| CPMG Inc | 10% Owner | Dec 28, 2022 | Option Exercise | $3.25 | 1,465,770 | 4,763,753 | 3,687,781 | Dec 30, 2022, 05:22 PM |
| CPMG Inc | 10% Owner | Dec 28, 2022 | Option Exercise | $3.25 | 586,308 | 1,905,501 | 1,310,701 | Dec 30, 2022, 05:22 PM |
| CPMG Inc | 10% Owner | Dec 28, 2022 | Option Exercise | $3.25 | 146,577 | 476,375 | 675,181 | Dec 30, 2022, 05:22 PM |
| Black Jeffrey G. | Chief Financial Officer | Nov 04, 2022 | Option Exercise | $6.46 | 15,060 | 97,288 | 332,650 | Nov 04, 2022, 06:22 PM |
| Black Jeffrey G. | Chief Financial Officer | Aug 05, 2022 | Option Exercise | $6.46 | 6,190 | 39,987 | 347,710 | Aug 05, 2022, 06:06 PM |
| McKhann Chas | President and CEO | May 05, 2022 | Option Exercise | $5.42 | 66,553 | 360,717 | 577,273 | May 09, 2022, 04:31 PM |
| Black Jeffrey G. | Chief Financial Officer | Mar 01, 2022 | Buy | $6.20 | 10,000 | 62,000 | 265,000 | Mar 01, 2022, 06:22 PM |
| Black Jeffrey G. | Chief Financial Officer | Feb 28, 2022 | Buy | $5.66 | 15,000 | 84,900 | 255,000 | Mar 01, 2022, 06:22 PM |
| Black Jeffrey G. | Chief Financial Officer | Feb 25, 2022 | Buy | $5.48 | 15,000 | 82,200 | 240,000 | Mar 01, 2022, 06:22 PM |
| CPMG Inc | 10% Owner | Oct 15, 2021 | Buy | $7.75 | 258,064 | 1,999,996 | 696,071 | Oct 19, 2021, 06:43 PM |
| CPMG Inc | 10% Owner | Oct 15, 2021 | Buy | $7.75 | 38,710 | 300,003 | 521,522 | Oct 19, 2021, 06:43 PM |
| CPMG Inc | 10% Owner | Oct 15, 2021 | Buy | $7.75 | 387,097 | 3,000,002 | 2,151,209 | Oct 19, 2021, 06:43 PM |
| McGaughy R Kent Jr | Director | Oct 15, 2021 | Buy | $7.75 | 387,097 | 3,000,002 | 2,151,209 | Oct 19, 2021, 06:41 PM |
| McGaughy R Kent Jr | Director | Oct 15, 2021 | Buy | $7.75 | 258,064 | 1,999,996 | 696,071 | Oct 19, 2021, 06:41 PM |
| McGaughy R Kent Jr | Director | Oct 15, 2021 | Buy | $7.75 | 38,710 | 300,003 | 521,522 | Oct 19, 2021, 06:41 PM |
| McKhann Chas | President and CEO | Aug 19, 2021 | Sale | $7.89 | 21,148 | 166,858 | 664,974 | Aug 20, 2021, 08:55 PM |
| McKhann Chas | President and CEO | Aug 18, 2021 | Sale | $8.21 | 21,156 | 173,691 | 686,122 | Aug 20, 2021, 08:55 PM |
| McKhann Chas | President and CEO | Aug 20, 2021 | Sale | $7.74 | 21,148 | 163,686 | 643,826 | Aug 20, 2021, 08:55 PM |
| McKhann Chas | President and CEO | Aug 20, 2021 | Sale | $7.74 | 21,148 | 163,686 | 643,826 | Aug 20, 2021, 05:42 PM |
| McKhann Chas | President and CEO | Aug 19, 2021 | Sale | $7.89 | 21,148 | 166,858 | 664,974 | Aug 20, 2021, 05:42 PM |
| McKhann Chas | President and CEO | Aug 18, 2021 | Sale | $8.21 | 21,156 | 173,691 | 686,122 | Aug 20, 2021, 05:42 PM |
| Black Jeffrey G. | Chief Financial Officer | Aug 11, 2021 | Buy | $8.75 | 25,000 | 218,750 | 25,000 | Aug 11, 2021, 08:25 PM |
| Pacitti David | Director | May 19, 2021 | Sale | $6.87 | 18,742 | 128,839 | 18,142 | May 20, 2021, 05:50 PM |
| Gagnon Neil | 10% Owner | Apr 05, 2021 | Buy | $5.48 | 303 | 1,661 | 402,580 | Apr 13, 2021, 04:05 PM |
| BARR JOHN R | Director | Mar 10, 2021 | Buy | $5.89 | 10,000 | 58,929 | 25,970 | Mar 12, 2021, 05:44 PM |
| Gagnon Neil | 10% Owner | Feb 23, 2021 | Buy | $4.62 | 4,166 | 19,230 | 26,446 | Feb 24, 2021, 04:06 PM |
| Gagnon Neil | 10% Owner | Feb 23, 2021 | Buy | $4.62 | 8,055 | 37,182 | 402,277 | Feb 24, 2021, 04:06 PM |
| Gagnon Neil | 10% Owner | Feb 22, 2021 | Buy | $4.80 | 10,103 | 48,524 | 394,222 | Feb 24, 2021, 04:06 PM |
| Gagnon Neil | 10% Owner | Feb 18, 2021 | Buy | $4.75 | 378 | 1,795 | 22,280 | Feb 22, 2021, 04:06 PM |
| Gagnon Neil | 10% Owner | Feb 18, 2021 | Buy | $4.75 | 1,649 | 7,830 | 384,119 | Feb 22, 2021, 04:06 PM |
| Gagnon Neil | 10% Owner | Feb 05, 2021 | Buy | $5.14 | 15,488 | 79,630 | 116,360 | Feb 08, 2021, 05:13 PM |
| Gagnon Neil | 10% Owner | Feb 05, 2021 | Buy | $4.71 | 30,954 | 145,861 | 382,470 | Feb 08, 2021, 05:13 PM |
| Gagnon Neil | 10% Owner | Feb 05, 2021 | Buy | $4.84 | 7,101 | 34,344 | 21,902 | Feb 08, 2021, 05:13 PM |
| Gagnon Neil | 10% Owner | Feb 03, 2021 | Buy | $4.49 | 145 | 651 | 14,801 | Feb 05, 2021, 04:31 PM |
| Gagnon Neil | 10% Owner | Feb 04, 2021 | Buy | $4.71 | 9,729 | 45,845 | 100,872 | Feb 05, 2021, 04:31 PM |
| Gagnon Neil | 10% Owner | Feb 03, 2021 | Buy | $4.46 | 28,243 | 125,927 | 91,143 | Feb 05, 2021, 04:31 PM |
| Gagnon Neil | 10% Owner | Feb 02, 2021 | Buy | $4.42 | 10,873 | 48,058 | 62,900 | Feb 03, 2021, 04:05 PM |
| Gagnon Neil | 10% Owner | Feb 01, 2021 | Buy | $4.20 | 473 | 1,988 | 351,516 | Feb 03, 2021, 04:05 PM |
| Gagnon Neil | 10% Owner | Dec 16, 2020 | Sale | $4.16 | 8,314 | 34,613 | 351,043 | Dec 17, 2020, 06:49 PM |
| Gagnon Neil | 10% Owner | Dec 16, 2020 | Sale | $4.16 | 2,488 | 10,358 | 14,656 | Dec 17, 2020, 06:49 PM |
| Gagnon Neil | 10% Owner | Oct 28, 2020 | Sale | $1.65 | 9,663 | 15,944 | 1,200,769 | Dec 17, 2020, 06:49 PM |
| Gagnon Neil | 10% Owner | Oct 28, 2020 | Sale | $1.65 | 693 | 1,143 | 52,027 | Dec 17, 2020, 06:49 PM |
| McGaughy R Kent Jr | Director | Jul 17, 2020 | Buy | $1.25 | 1,200,000 | 1,500,000 | 1,707,208 | Jul 21, 2020, 06:40 PM |
| McGaughy R Kent Jr | Director | Jul 17, 2020 | Buy | $1.25 | 400,000 | 500,000 | 415,244 | Jul 21, 2020, 06:40 PM |
| McGaughy R Kent Jr | Director | Jul 17, 2020 | Buy | $1.25 | 180,000 | 225,000 | 477,120 | Jul 21, 2020, 06:40 PM |
| CPMG Inc | 10% Owner | Jul 17, 2020 | Buy | $1.25 | 1,200,000 | 1,500,000 | 1,707,208 | Jul 21, 2020, 06:39 PM |
| CPMG Inc | 10% Owner | Jul 17, 2020 | Buy | $1.25 | 400,000 | 500,000 | 415,244 | Jul 21, 2020, 06:39 PM |
| CPMG Inc | 10% Owner | Jul 17, 2020 | Buy | $1.25 | 180,000 | 225,000 | 477,120 | Jul 21, 2020, 06:39 PM |
| Pacitti David | Director | Aug 16, 2019 | Option Exercise | $3.27 | 5,399 | 17,655 | 8,736 | Aug 20, 2019, 04:33 PM |
| Newton Todd | Chief Executive Officer | May 14, 2019 | Option Exercise | $3.54 | 3,600 | 12,750 | 321,268 | May 14, 2019, 05:28 PM |
| Newton Todd | Chief Executive Officer | May 10, 2019 | Buy | $3.53 | 25,000 | 88,350 | 317,668 | May 14, 2019, 05:28 PM |
| STONEPINE CAPITAL, L.P. | 10% Owner | Dec 27, 2018 | Sale | $3.00 | 250,000 | 750,000 | 2,185,426 | Dec 31, 2018, 07:44 PM |
| STONEPINE CAPITAL, L.P. | 10% Owner | Dec 26, 2018 | Sale | $3.00 | 500,000 | 1,500,000 | 2,435,426 | Dec 28, 2018, 08:55 PM |
| STONEPINE CAPITAL, L.P. | 10% Owner | Nov 19, 2018 | Buy | $3.40 | 54,200 | 184,280 | 2,932,196 | Nov 21, 2018, 05:32 PM |
| STONEPINE CAPITAL, L.P. | 10% Owner | Nov 21, 2018 | Buy | $3.61 | 3,230 | 11,644 | 2,935,426 | Nov 21, 2018, 05:32 PM |
| STONEPINE CAPITAL, L.P. | 10% Owner | Nov 02, 2018 | Buy | $5.00 | 300,000 | 1,500,000 | 2,877,996 | Nov 06, 2018, 04:22 PM |
| Crawford Matthew S | Director | Jun 20, 2018 | Buy | $5.50 | 363,500 | 1,999,250 | 417,215 | Jun 22, 2018, 04:37 PM |
| Cavanaugh Stefanie L. | CFO, Treasurer, Secretary | Jun 20, 2018 | Buy | $5.50 | 4,545 | 24,998 | 19,569 | Jun 22, 2018, 04:35 PM |
| Newton Todd | Chief Executive Officer | Jun 20, 2018 | Buy | $5.50 | 72,727 | 399,999 | 268,606 | Jun 22, 2018, 04:34 PM |
| Crawford Matthew S | Director | Mar 09, 2018 | Buy | $6.20 | 4,038 | 25,036 | 53,715 | Mar 13, 2018, 06:15 PM |
| STONEPINE CAPITAL, L.P. | 10% Owner | Jan 03, 2018 | Buy | $5.78 | 6,339 | 36,656 | 2,577,996 | Jan 03, 2018, 05:33 PM |
| STONEPINE CAPITAL, L.P. | 10% Owner | Jan 02, 2018 | Buy | $5.73 | 11,343 | 64,960 | 2,571,657 | Jan 03, 2018, 05:33 PM |
| STONEPINE CAPITAL, L.P. | 10% Owner | Dec 29, 2017 | Buy | $5.56 | 5,163 | 28,717 | 2,560,314 | Jan 03, 2018, 05:33 PM |
| STONEPINE CAPITAL, L.P. | 10% Owner | Dec 26, 2017 | Buy | $5.00 | 5,287 | 26,435 | 2,555,151 | Dec 28, 2017, 05:03 PM |
| STONEPINE CAPITAL, L.P. | 10% Owner | Dec 22, 2017 | Buy | $5.00 | 41,399 | 206,863 | 2,549,864 | Dec 22, 2017, 05:26 PM |
| STONEPINE CAPITAL, L.P. | 10% Owner | Dec 21, 2017 | Buy | $4.94 | 98,324 | 485,947 | 2,508,465 | Dec 22, 2017, 05:26 PM |
| STONEPINE CAPITAL, L.P. | 10% Owner | Dec 20, 2017 | Buy | $4.50 | 45,434 | 204,312 | 2,410,141 | Dec 22, 2017, 05:26 PM |
| Schwartzhoff Bret | V.P. U.S. Sales and Marketing | Nov 07, 2017 | Buy | $4.24 | 9,500 | 40,280 | 15,631 | Nov 09, 2017, 07:10 PM |
| PTV SCIENCES II L P | 10% Owner | Sep 12, 2017 | Buy | $3.85 | 135,000 | 519,750 | 1,266,909 | Sep 25, 2017, 03:50 PM |
| PTV SCIENCES II L P | 10% Owner | Sep 05, 2017 | Buy | $4.04 | 41,000 | 165,640 | 1,131,909 | Sep 25, 2017, 03:50 PM |
| Crawford Matthew S | Director | Sep 12, 2017 | Buy | $3.85 | 135,000 | 519,750 | 1,266,909 | Sep 25, 2017, 03:23 PM |
| Crawford Matthew S | Director | Sep 05, 2017 | Buy | $4.04 | 41,000 | 165,640 | 1,131,909 | Sep 25, 2017, 03:23 PM |
| Anderson Rick D | Director | Sep 12, 2017 | Buy | $3.85 | 135,000 | 519,750 | 1,266,909 | Sep 25, 2017, 03:15 PM |
| Anderson Rick D | Director | Sep 05, 2017 | Buy | $4.04 | 41,000 | 165,640 | 1,131,909 | Sep 25, 2017, 03:15 PM |
| McWilliams Dennis L. | President, CCO | Sep 15, 2017 | Option Exercise | $1.76 | 28,757 | 50,612 | 62,404 | Sep 19, 2017, 08:54 PM |
| PTV SCIENCES II L P | 10% Owner | Jul 25, 2017 | Buy | $5.50 | 1,090,909 | 6,000,000 | 5,243,372 | Jul 26, 2017, 07:27 PM |
| Novo Holdings A/S | 10% Owner | Jul 26, 2017 | Sale | $6.84 | 8,426 | 57,643 | 1,301,842 | Jul 26, 2017, 07:22 PM |
| Novo Holdings A/S | 10% Owner | Jul 25, 2017 | Sale | $6.96 | 24,504 | 170,585 | 1,310,268 | Jul 26, 2017, 07:22 PM |
| Novo Holdings A/S | 10% Owner | Jul 24, 2017 | Sale | $6.83 | 17,200 | 117,538 | 1,334,772 | Jul 26, 2017, 07:22 PM |
| Anderson Rick D | Director | Jul 25, 2017 | Buy | $5.50 | 1,090,909 | 6,000,000 | 1,090,909 | Jul 26, 2017, 06:39 PM |
| Anderson Rick D | Director | Jul 25, 2017 | Buy | $5.50 | 45,454 | 249,997 | 45,454 | Jul 26, 2017, 06:39 PM |
| Crawford Matthew S | Director | Jul 25, 2017 | Buy | $5.50 | 1,090,909 | 6,000,000 | 1,090,909 | Jul 26, 2017, 06:38 PM |
| Crawford Matthew S | Director | Jul 25, 2017 | Buy | $5.50 | 45,454 | 249,997 | 45,454 | Jul 26, 2017, 06:38 PM |
| MEELIA RICHARD J | Director | Jul 25, 2017 | Buy | $5.50 | 45,454 | 249,997 | 45,454 | Jul 26, 2017, 06:20 PM |
| McGaughy R Kent Jr | Director | Jul 25, 2017 | Buy | $5.50 | 8,986 | 49,423 | 45,594 | Jul 26, 2017, 06:02 PM |
| McGaughy R Kent Jr | Director | Jul 25, 2017 | Buy | $5.50 | 273,770 | 1,505,735 | 469,100 | Jul 26, 2017, 06:02 PM |
| McGaughy R Kent Jr | Director | Jul 25, 2017 | Buy | $5.50 | 78,965 | 434,308 | 400,675 | Jul 26, 2017, 06:02 PM |
| McGaughy R Kent Jr | Director | Jul 25, 2017 | Buy | $5.50 | 12,548 | 69,014 | 63,671 | Jul 26, 2017, 06:02 PM |
| McGaughy R Kent Jr | Director | Jul 25, 2017 | Buy | $5.50 | 80,276 | 441,518 | 293,309 | Jul 26, 2017, 06:02 PM |
| Cavanaugh Stefanie L. | CFO, Treasurer, Secretary | Jul 25, 2017 | Buy | $5.50 | 4,545 | 24,998 | 9,166 | Jul 26, 2017, 05:59 PM |
| Newton Todd | Chief Executive Officer | Jul 25, 2017 | Buy | $5.50 | 136,363 | 749,997 | 167,129 | Jul 26, 2017, 05:54 PM |
| McClellan William D. Jr. | Director | May 17, 2017 | Buy | $6.35 | 1,700 | 10,795 | 2,000 | May 30, 2017, 07:46 PM |
| McClellan William D. Jr. | Director | May 16, 2017 | Buy | $6.19 | 300 | 1,857 | 300 | May 30, 2017, 07:46 PM |
| MEELIA RICHARD J | Director | Dec 29, 2016 | Option Exercise | $1.36 | 17,501 | 23,801 | 17,501 | May 30, 2017, 05:56 PM |
| McClellan William D. Jr. | Director | May 16, 2017 | Buy | $6.19 | 300 | 1,857 | 300 | May 18, 2017, 08:48 PM |
| McClellan William D. Jr. | Director | May 17, 2017 | Buy | $6.35 | 1,700 | 10,794 | 2,000 | May 18, 2017, 08:48 PM |
| Newton Todd | Chief Executive Officer | May 18, 2017 | Buy | $6.35 | 822 | 5,220 | 30,766 | May 18, 2017, 08:44 PM |
| Newton Todd | Chief Executive Officer | May 17, 2017 | Buy | $6.19 | 400 | 2,476 | 29,944 | May 18, 2017, 08:44 PM |
| Newton Todd | Chief Executive Officer | May 16, 2017 | Buy | $6.12 | 899 | 5,502 | 29,544 | May 18, 2017, 08:44 PM |
| Novo A/S | 10% Owner | May 11, 2017 | Sale | $5.62 | 103,500 | 582,094 | 1,351,972 | May 11, 2017, 06:00 PM |
| Novo A/S | 10% Owner | May 10, 2017 | Sale | $5.74 | 1,500 | 8,608 | 1,455,472 | May 11, 2017, 06:00 PM |
| Atkinson Gary J G | CEO and CFO | Mar 09, 2016 | Option Exercise | $0.19 | 3,325 | 632 | 32,116 | Mar 16, 2016, 04:06 PM |
| Atkinson Gary J G | Senior Vice President and CFO | Feb 10, 2015 | Option Exercise | $2.87 | 2,500 | 7,175 | 25,941 | Feb 11, 2015, 05:37 PM |
| Petree Daniel H | Director | Dec 12, 2014 | Buy | $2.79 | 10,000 | 27,901 | 13,286 | Dec 12, 2014, 04:58 PM |
| Atkinson Gary J G | Senior Vice President. & CFO | Aug 20, 2014 | Buy | $3.10 | 5,000 | 15,500 | 21,298 | Aug 21, 2014, 12:29 PM |
| PANCOAST SCOTT R | President & CEO | Aug 19, 2014 | Buy | $3.00 | 10,000 | 30,000 | 116,435 | Aug 19, 2014, 05:15 PM |
| PANCOAST SCOTT R | President & CEO | Feb 19, 2014 | Option Exercise | $4.66 | 6,000 | 27,960 | 96,435 | Aug 18, 2014, 06:37 PM |
| PANCOAST SCOTT R | President & CEO | Aug 18, 2014 | Buy | $3.22 | 10,000 | 32,234 | 106,435 | Aug 18, 2014, 06:37 PM |
| Atkinson Gary J G | Senior Vice President and CFO | Feb 10, 2014 | Option Exercise | $4.45 | 1,900 | 8,455 | 16,298 | Feb 12, 2014, 07:02 PM |
| PANCOAST SCOTT R | President & CEO | Feb 10, 2014 | Option Exercise | $4.45 | 7,500 | 33,375 | 102,435 | Feb 12, 2014, 07:01 PM |
| PANCOAST SCOTT R | President and CEO | Oct 09, 2013 | Option Exercise | $0.47 | 26,430 | 12,551 | 88,506 | Oct 11, 2013, 07:06 PM |
| MATHEWS CHARLES | Director | Dec 19, 2012 | Buy | $4.98 | 5,000 | 24,900 | 7,858 | Dec 20, 2012, 01:56 PM |
| PANCOAST SCOTT R | President and CEO | Dec 18, 2012 | Buy | $4.95 | 5,000 | 24,750 | 67,076 | Dec 19, 2012, 12:02 PM |
| PANCOAST SCOTT R | President and CEO | Nov 20, 2012 | Option Exercise | $5.99 | 27,775 | 166,372 | 62,076 | Nov 21, 2012, 06:07 PM |
| Atkinson Gary J G | Sr. Vice President & CFO | Nov 20, 2012 | Option Exercise | $5.99 | 6,875 | 41,181 | 12,769 | Nov 21, 2012, 06:06 PM |
| Swortwood Donald | Director | Oct 25, 2012 | Option Exercise | $1.12 | 32,355 | 36,238 | 683,957 | Oct 29, 2012, 04:43 PM |
| BARCLAYS PLC | 10% Owner | Jan 04, 2011 | Sale | $0.80 | 13,800 | 11,040 | 5,307,300 | Jan 05, 2011, 11:23 AM |
| BARCLAYS PLC | 10% Owner | Jan 03, 2011 | Sale | $0.72 | 1,100,000 | 792,000 | 5,321,100 | Jan 05, 2011, 11:23 AM |
| BARCLAYS PLC | 10% Owner | Dec 17, 2010 | Sale | $0.70 | 2,000,000 | 1,400,000 | 6,421,100 | Dec 21, 2010, 11:23 AM |
| Sabbadini Roger Allen | VP & Chief Scientific Officer | Sep 28, 2010 | Option Exercise | $0.11 | 200,000 | 22,000 | 1,035,800 | Sep 30, 2010, 01:08 PM |
Load More Insider Transactions
Buy
Sale
Option Exercise
| Owner | Relationship | Date | Value($) |
| McGaughy R Kent Jr | Director | 12/28/2022 | 4,763,753 |
| McGaughy R Kent Jr | Director | 12/28/2022 | 1,905,501 |
| McGaughy R Kent Jr | Director | 12/28/2022 | 476,375 |
| CPMG Inc | 10% Owner | 12/28/2022 | 4,763,753 |
| CPMG Inc | 10% Owner | 12/28/2022 | 1,905,501 |
| CPMG Inc | 10% Owner | 12/28/2022 | 476,375 |
| Black Jeffrey G. | Chief Financial Officer | 11/04/2022 | 97,288 |
| Black Jeffrey G. | Chief Financial Officer | 08/05/2022 | 39,987 |
| McKhann Chas | President and CEO | 05/05/2022 | 360,717 |
| Black Jeffrey G. | Chief Financial Officer | 03/01/2022 | 62,000 |
| Black Jeffrey G. | Chief Financial Officer | 02/28/2022 | 84,900 |
| Black Jeffrey G. | Chief Financial Officer | 02/25/2022 | 82,200 |
| CPMG Inc | 10% Owner | 10/15/2021 | 1,999,996 |
| CPMG Inc | 10% Owner | 10/15/2021 | 300,003 |
| CPMG Inc | 10% Owner | 10/15/2021 | 3,000,002 |
| McGaughy R Kent Jr | Director | 10/15/2021 | 3,000,002 |
| McGaughy R Kent Jr | Director | 10/15/2021 | 1,999,996 |
| McGaughy R Kent Jr | Director | 10/15/2021 | 300,003 |
| McKhann Chas | President and CEO | 08/19/2021 | 166,858 |
| McKhann Chas | President and CEO | 08/18/2021 | 173,691 |
| McKhann Chas | President and CEO | 08/20/2021 | 163,686 |
| McKhann Chas | President and CEO | 08/20/2021 | 163,686 |
| McKhann Chas | President and CEO | 08/19/2021 | 166,858 |
| McKhann Chas | President and CEO | 08/18/2021 | 173,691 |
| Black Jeffrey G. | Chief Financial Officer | 08/11/2021 | 218,750 |
| Pacitti David | Director | 05/19/2021 | 128,839 |
| Gagnon Neil | 10% Owner | 04/05/2021 | 1,661 |
| BARR JOHN R | Director | 03/10/2021 | 58,929 |
| Gagnon Neil | 10% Owner | 02/23/2021 | 19,230 |
| Gagnon Neil | 10% Owner | 02/23/2021 | 37,182 |
| Gagnon Neil | 10% Owner | 02/22/2021 | 48,524 |
| Gagnon Neil | 10% Owner | 02/18/2021 | 1,795 |
| Gagnon Neil | 10% Owner | 02/18/2021 | 7,830 |
| Gagnon Neil | 10% Owner | 02/05/2021 | 79,630 |
| Gagnon Neil | 10% Owner | 02/05/2021 | 145,861 |
| Gagnon Neil | 10% Owner | 02/05/2021 | 34,344 |
| Gagnon Neil | 10% Owner | 02/03/2021 | 651 |
| Gagnon Neil | 10% Owner | 02/04/2021 | 45,845 |
| Gagnon Neil | 10% Owner | 02/03/2021 | 125,927 |
| Gagnon Neil | 10% Owner | 02/02/2021 | 48,058 |
| Gagnon Neil | 10% Owner | 02/01/2021 | 1,988 |
| Gagnon Neil | 10% Owner | 12/16/2020 | 34,613 |
| Gagnon Neil | 10% Owner | 12/16/2020 | 10,358 |
| Gagnon Neil | 10% Owner | 10/28/2020 | 15,944 |
| Gagnon Neil | 10% Owner | 10/28/2020 | 1,143 |
| McGaughy R Kent Jr | Director | 07/17/2020 | 1,500,000 |
| McGaughy R Kent Jr | Director | 07/17/2020 | 500,000 |
| McGaughy R Kent Jr | Director | 07/17/2020 | 225,000 |
| CPMG Inc | 10% Owner | 07/17/2020 | 1,500,000 |
| CPMG Inc | 10% Owner | 07/17/2020 | 500,000 |
| CPMG Inc | 10% Owner | 07/17/2020 | 225,000 |
| Pacitti David | Director | 08/16/2019 | 17,655 |
| Newton Todd | Chief Executive Officer | 05/14/2019 | 12,750 |
| Newton Todd | Chief Executive Officer | 05/10/2019 | 88,350 |
| STONEPINE CAPITAL, L.P. | 10% Owner | 12/27/2018 | 750,000 |
| STONEPINE CAPITAL, L.P. | 10% Owner | 12/26/2018 | 1,500,000 |
| STONEPINE CAPITAL, L.P. | 10% Owner | 11/19/2018 | 184,280 |
| STONEPINE CAPITAL, L.P. | 10% Owner | 11/21/2018 | 11,644 |
| STONEPINE CAPITAL, L.P. | 10% Owner | 11/02/2018 | 1,500,000 |
| Crawford Matthew S | Director | 06/20/2018 | 1,999,250 |
| Cavanaugh Stefanie L. | CFO, Treasurer, Secretary | 06/20/2018 | 24,998 |
| Newton Todd | Chief Executive Officer | 06/20/2018 | 399,999 |
| Crawford Matthew S | Director | 03/09/2018 | 25,036 |
| STONEPINE CAPITAL, L.P. | 10% Owner | 01/03/2018 | 36,656 |
| STONEPINE CAPITAL, L.P. | 10% Owner | 01/02/2018 | 64,960 |
| STONEPINE CAPITAL, L.P. | 10% Owner | 12/29/2017 | 28,717 |
| STONEPINE CAPITAL, L.P. | 10% Owner | 12/26/2017 | 26,435 |
| STONEPINE CAPITAL, L.P. | 10% Owner | 12/22/2017 | 206,863 |
| STONEPINE CAPITAL, L.P. | 10% Owner | 12/21/2017 | 485,947 |
| STONEPINE CAPITAL, L.P. | 10% Owner | 12/20/2017 | 204,312 |
| Schwartzhoff Bret | V.P. U.S. Sales and Marketing | 11/07/2017 | 40,280 |
| PTV SCIENCES II L P | 10% Owner | 09/12/2017 | 519,750 |
| PTV SCIENCES II L P | 10% Owner | 09/05/2017 | 165,640 |
| Crawford Matthew S | Director | 09/12/2017 | 519,750 |
| Crawford Matthew S | Director | 09/05/2017 | 165,640 |
| Anderson Rick D | Director | 09/12/2017 | 519,750 |
| Anderson Rick D | Director | 09/05/2017 | 165,640 |
| McWilliams Dennis L. | President, CCO | 09/15/2017 | 50,612 |
| PTV SCIENCES II L P | 10% Owner | 07/25/2017 | 6,000,000 |
| Novo Holdings A/S | 10% Owner | 07/26/2017 | 57,643 |
| Novo Holdings A/S | 10% Owner | 07/25/2017 | 170,585 |
| Novo Holdings A/S | 10% Owner | 07/24/2017 | 117,538 |
| Anderson Rick D | Director | 07/25/2017 | 6,000,000 |
| Anderson Rick D | Director | 07/25/2017 | 249,997 |
| Crawford Matthew S | Director | 07/25/2017 | 6,000,000 |
| Crawford Matthew S | Director | 07/25/2017 | 249,997 |
| MEELIA RICHARD J | Director | 07/25/2017 | 249,997 |
| McGaughy R Kent Jr | Director | 07/25/2017 | 49,423 |
| McGaughy R Kent Jr | Director | 07/25/2017 | 1,505,735 |
| McGaughy R Kent Jr | Director | 07/25/2017 | 434,308 |
| McGaughy R Kent Jr | Director | 07/25/2017 | 69,014 |
| McGaughy R Kent Jr | Director | 07/25/2017 | 441,518 |
| Cavanaugh Stefanie L. | CFO, Treasurer, Secretary | 07/25/2017 | 24,998 |
| Newton Todd | Chief Executive Officer | 07/25/2017 | 749,997 |
| McClellan William D. Jr. | Director | 05/17/2017 | 10,795 |
| McClellan William D. Jr. | Director | 05/16/2017 | 1,857 |
| MEELIA RICHARD J | Director | 12/29/2016 | 23,801 |
| McClellan William D. Jr. | Director | 05/16/2017 | 1,857 |
| McClellan William D. Jr. | Director | 05/17/2017 | 10,794 |
| Newton Todd | Chief Executive Officer | 05/18/2017 | 5,220 |
| Newton Todd | Chief Executive Officer | 05/17/2017 | 2,476 |
| Newton Todd | Chief Executive Officer | 05/16/2017 | 5,502 |
| Novo A/S | 10% Owner | 05/11/2017 | 582,094 |
| Novo A/S | 10% Owner | 05/10/2017 | 8,608 |
| Atkinson Gary J G | CEO and CFO | 03/09/2016 | 632 |
| Atkinson Gary J G | Senior Vice President and CFO | 02/10/2015 | 7,175 |
| Petree Daniel H | Director | 12/12/2014 | 27,901 |
| Atkinson Gary J G | Senior Vice President. & CFO | 08/20/2014 | 15,500 |
| PANCOAST SCOTT R | President & CEO | 08/19/2014 | 30,000 |
| PANCOAST SCOTT R | President & CEO | 02/19/2014 | 27,960 |
| PANCOAST SCOTT R | President & CEO | 08/18/2014 | 32,234 |
| Atkinson Gary J G | Senior Vice President and CFO | 02/10/2014 | 8,455 |
| PANCOAST SCOTT R | President & CEO | 02/10/2014 | 33,375 |
| PANCOAST SCOTT R | President and CEO | 10/09/2013 | 12,551 |
| MATHEWS CHARLES | Director | 12/19/2012 | 24,900 |
| PANCOAST SCOTT R | President and CEO | 12/18/2012 | 24,750 |
| PANCOAST SCOTT R | President and CEO | 11/20/2012 | 166,372 |
| Atkinson Gary J G | Sr. Vice President & CFO | 11/20/2012 | 41,181 |
| Swortwood Donald | Director | 10/25/2012 | 36,238 |
| BARCLAYS PLC | 10% Owner | 01/04/2011 | 11,040 |
| BARCLAYS PLC | 10% Owner | 01/03/2011 | 792,000 |
| BARCLAYS PLC | 10% Owner | 12/17/2010 | 1,400,000 |
| Sabbadini Roger Allen | VP & Chief Scientific Officer | 09/28/2010 | 22,000 |
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