. (CLDN)
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As of 12/31/69 07:00 PM EST. Market closed.
. (CLDN)
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As of 12/31/69 07:00 PM EST. Market closed.
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INSIDER TRANSACTIONS FOR
| Owner | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| KAYNE RICHARD A | 10% Owner | Oct 31, 2023 | Buy | $0.24 | 154,841 | 37,880 | 5,251,827 | Nov 02, 2023, 09:21 PM |
| KAYNE RICHARD A | 10% Owner | Nov 02, 2023 | Buy | $0.30 | 23,398 | 6,966 | 5,375,225 | Nov 02, 2023, 09:21 PM |
| KAYNE RICHARD A | 10% Owner | Nov 01, 2023 | Buy | $0.28 | 100,000 | 27,970 | 5,351,827 | Nov 02, 2023, 09:21 PM |
| KAWAS LEEN | 10% Owner | Oct 31, 2023 | Buy | $0.26 | 24,332 | 6,375 | 4,391,432 | Nov 02, 2023, 09:14 PM |
| Mayer Eldon C. III | Ex VP & Chief Commerc. Officer | Mar 17, 2023 | Sale | $1.07 | 4,395 | 4,704 | 57,948 | Mar 21, 2023, 09:00 PM |
| Dietz Thomas John | Director | Jan 23, 2023 | Buy | $1.43 | 50,000 | 71,580 | 50,000 | Jan 25, 2023, 08:54 PM |
| Murray Christine | Director | Dec 29, 2022 | Sale | $1.22 | 5,000 | 6,104 | 11,000 | Jan 03, 2023, 08:30 PM |
| Dietz Thomas John | Director | Dec 22, 2022 | Sale | $1.17 | 22,500 | 26,303 | 21,000 | Dec 27, 2022, 05:31 PM |
| Glenn Jeffrey S | Director | Dec 22, 2022 | Buy | $1.28 | 100,000 | 127,950 | 182,355 | Dec 27, 2022, 05:31 PM |
| Apelian David | Director | Aug 16, 2022 | Sale | $9.81 | 5,000 | 49,030 | 11,000 | Aug 18, 2022, 05:36 PM |
| Ryali Sriram | Chief Financial Officer | Mar 14, 2022 | Sale | $5.60 | 2,266 | 12,683 | 41,566 | Mar 14, 2022, 09:22 PM |
| Mayer Eldon C. III | Ex VP & Chief Commerc. Officer | Mar 14, 2022 | Sale | $5.60 | 1,657 | 9,275 | 60,468 | Mar 14, 2022, 09:21 PM |
| Mayer Eldon C. III | Ex VP & Chief Commerc. Officer | Jan 07, 2022 | Sale | $4.95 | 1,560 | 7,722 | 46,125 | Jan 11, 2022, 08:59 PM |
| Dietz Thomas John | Director | Apr 09, 2021 | Buy | $8.49 | 2,500 | 21,220 | 37,500 | Apr 12, 2021, 06:10 PM |
| Loh Evan | Director | Mar 15, 2021 | Sale | $10.14 | 2,000 | 20,280 | 8,000 | Mar 15, 2021, 07:30 PM |
| Mayer Eldon C. III | Ex VP & Chief Commerc. Officer | Jan 08, 2021 | Sale | $11.68 | 1,690 | 19,739 | 35,810 | Jan 11, 2021, 06:10 PM |
| Glenn Jeffrey S | Director | Aug 12, 2020 | Buy | $11.42 | 5,000 | 57,103 | 5,000 | Aug 12, 2020, 06:28 PM |
| Glenn Jeffrey S | Director | Aug 11, 2020 | Buy | $11.49 | 5,000 | 57,463 | 71,355 | Aug 12, 2020, 06:28 PM |
| Dietz Thomas John | Director | Mar 16, 2020 | Buy | $4.95 | 1,000 | 4,950 | 30,000 | Mar 17, 2020, 05:17 PM |
| Glenn Jeffrey S | Director | Mar 16, 2020 | Buy | $5.03 | 30,000 | 150,813 | 66,355 | Mar 17, 2020, 05:16 PM |
| Shaffer James P | Chief Business Officer | Mar 05, 2020 | Option Exercise | $7.31 | 1,500 | 10,965 | 15,921 | Mar 13, 2020, 05:40 PM |
| Ryali Sriram | Chief Financial Officer | Mar 05, 2020 | Option Exercise | $7.31 | 229 | 1,674 | 1,628 | Mar 13, 2020, 05:35 PM |
| Patton Stephana Eilene | See Remarks | Mar 05, 2020 | Option Exercise | $7.31 | 820 | 5,994 | 4,820 | Mar 13, 2020, 05:30 PM |
| Cory David A | President and CEO | Mar 05, 2020 | Option Exercise | $7.31 | 1,500 | 10,965 | 69,346 | Mar 13, 2020, 05:23 PM |
| Mayer Eldon C. III | Ex VP & Chief Commerc. Officer | Jan 24, 2020 | Buy | $13.52 | 5,000 | 67,603 | 30,000 | Jan 30, 2020, 04:44 PM |
| Dietz Thomas John | Director | Jan 10, 2020 | Buy | $13.94 | 4,000 | 55,760 | 24,000 | Jan 13, 2020, 08:17 AM |
| Shaffer James P | Chief Business Officer | Sep 05, 2019 | Option Exercise | $7.95 | 1,500 | 11,921 | 14,421 | Sep 06, 2019, 06:37 PM |
| Ryali Sriram | Chief Financial Officer | Sep 05, 2019 | Option Exercise | $9.37 | 149 | 1,396 | 1,399 | Sep 06, 2019, 05:47 PM |
| Cory David A | President and CEO | Sep 05, 2019 | Option Exercise | $7.95 | 1,500 | 11,921 | 67,846 | Sep 06, 2019, 05:46 PM |
| Cory David A | President and CEO | Feb 04, 2019 | Buy | $11.26 | 343 | 3,862 | 66,346 | Apr 26, 2019, 04:54 PM |
| Dietz Thomas John | Director | Apr 23, 2019 | Buy | $11.10 | 5,000 | 55,495 | 20,000 | Apr 23, 2019, 06:53 PM |
| Ryali Sriram | Chief Financial Officer | Apr 22, 2019 | Buy | $11.08 | 1,250 | 13,853 | 1,250 | Apr 22, 2019, 09:34 PM |
| Dietz Thomas John | Director | Apr 22, 2019 | Buy | $11.05 | 5,000 | 55,250 | 15,000 | Apr 22, 2019, 09:34 PM |
| Patton Stephana Eilene | See Remarks | Apr 22, 2019 | Buy | $11.03 | 1,000 | 11,030 | 4,000 | Apr 22, 2019, 09:31 PM |
| Shaffer James P | Chief Business Officer | Mar 05, 2019 | Option Exercise | $7.95 | 1,500 | 11,921 | 12,921 | Mar 26, 2019, 10:12 AM |
| Shaffer James P | Chief Business Officer | Sep 05, 2018 | Option Exercise | $7.95 | 1,500 | 11,921 | 11,421 | Mar 26, 2019, 10:12 AM |
| Shaffer James P | Chief Business Officer | Mar 05, 2018 | Option Exercise | $8.03 | 1,500 | 12,049 | 9,921 | Mar 26, 2019, 10:12 AM |
| Shaffer James P | Chief Business Officer | Sep 05, 2017 | Option Exercise | $9.90 | 1,500 | 14,854 | 8,421 | Mar 26, 2019, 10:12 AM |
| Shaffer James P | Chief Business Officer | Mar 06, 2017 | Option Exercise | $8.20 | 1,301 | 10,671 | 6,921 | Mar 26, 2019, 10:12 AM |
| Cory David A | President and CEO | Sep 05, 2018 | Option Exercise | $7.95 | 1,500 | 11,921 | 64,503 | Mar 26, 2019, 10:07 AM |
| Cory David A | President and CEO | Mar 05, 2018 | Option Exercise | $8.03 | 1,500 | 12,049 | 63,003 | Mar 26, 2019, 10:07 AM |
| Cory David A | President and CEO | Sep 05, 2017 | Option Exercise | $9.90 | 1,500 | 14,854 | 61,503 | Mar 26, 2019, 10:07 AM |
| Cory David A | President and CEO | Mar 06, 2017 | Option Exercise | $8.20 | 1,325 | 10,868 | 60,003 | Mar 26, 2019, 10:07 AM |
| Cory David A | President and CEO | Mar 05, 2019 | Option Exercise | $7.95 | 1,500 | 11,921 | 66,003 | Mar 26, 2019, 10:07 AM |
| Cory David A | President and CEO | Feb 04, 2019 | Buy | $14.13 | 227 | 3,208 | 58,678 | Feb 06, 2019, 07:23 PM |
| Dietz Thomas John | Director | Dec 20, 2018 | Buy | $9.98 | 5,000 | 49,900 | 10,000 | Dec 20, 2018, 08:29 PM |
| Dietz Thomas John | Director | Dec 06, 2018 | Buy | $11.26 | 5,000 | 56,300 | 5,000 | Dec 10, 2018, 04:05 PM |
| Mayer Eldon C. III | Director | Nov 29, 2018 | Buy | $10.21 | 4,000 | 40,840 | 25,000 | Nov 30, 2018, 02:26 PM |
| Mayer Eldon C. III | Director | Nov 28, 2001 | Buy | $10.07 | 6,000 | 60,447 | 21,000 | Nov 28, 2018, 08:51 PM |
| Mayer Eldon C. III | Director | Nov 27, 2018 | Buy | $9.92 | 7,500 | 74,407 | 15,000 | Nov 28, 2018, 08:51 PM |
| Mayer Eldon C. III | Director | Nov 26, 2018 | Buy | $9.75 | 7,500 | 73,143 | 7,500 | Nov 28, 2018, 08:51 PM |
| INTERWEST PARTNERS X LP | 10% Owner | Oct 18, 2018 | Sale | $12.06 | 237,265 | 2,862,321 | 1,388,792 | Oct 22, 2018, 04:33 PM |
| Quan Joanne | Chief Medical Officer | Apr 02, 2018 | Option Exercise | $2.06 | 4,000 | 8,240 | 4,000 | Apr 04, 2018, 05:18 PM |
| Quan Joanne | Chief Medical Officer | Apr 02, 2018 | Sale | $10.00 | 4,000 | 40,000 | 0 | Apr 04, 2018, 05:18 PM |
| Glenn Jeffrey S | Director | Sep 01, 2017 | Buy | $9.53 | 15,000 | 142,950 | 31,355 | Sep 05, 2017, 06:20 PM |
| Glenn Jeffrey S | Director | Nov 18, 2016 | Buy | $12.90 | 460 | 5,934 | 460 | Nov 21, 2016, 05:11 PM |
| Glenn Jeffrey S | Director | Nov 17, 2016 | Buy | $12.73 | 15,000 | 190,950 | 16,355 | Nov 21, 2016, 05:11 PM |
| Vivo Ventures VI, LLC | 10% Owner | Aug 18, 2016 | Buy | $16.00 | 1,364 | 21,824 | 12,996 | Aug 22, 2016, 01:43 PM |
| Vivo Ventures VI, LLC | 10% Owner | Aug 18, 2016 | Buy | $16.00 | 186,136 | 2,978,176 | 1,774,096 | Aug 22, 2016, 01:43 PM |
| Cory David A | President and CEO | Aug 18, 2016 | Buy | $15.70 | 1,562 | 24,523 | 58,451 | Aug 19, 2016, 07:15 PM |
| Shaffer James P | Chief Business Officer | Aug 18, 2016 | Buy | $15.70 | 3,125 | 49,062 | 5,620 | Aug 19, 2016, 06:52 PM |
| WELCH JAMES H | Chief Financial Officer | Jun 22, 2016 | Buy | $19.79 | 500 | 9,897 | 2,500 | Jun 22, 2016, 02:55 PM |
| WELCH JAMES H | Chief Financial Officer | Jun 20, 2016 | Buy | $19.80 | 2,000 | 39,592 | 2,000 | Jun 22, 2016, 02:55 PM |
| Shaffer James P | Chief Business Officer | Jun 13, 2016 | Buy | $22.17 | 1,250 | 27,718 | 2,495 | Jun 14, 2016, 06:45 PM |
| Shaffer James P | Chief Business Officer | May 23, 2016 | Buy | $19.99 | 745 | 14,893 | 1,245 | May 23, 2016, 06:37 PM |
| Shaffer James P | Chief Business Officer | May 19, 2016 | Buy | $19.52 | 500 | 9,760 | 500 | May 23, 2016, 06:37 PM |
| ZSEBO KRISZTINA M | Chief Executive Officer | Apr 06, 2015 | Option Exercise | $2.07 | 47,931 | 99,290 | 51,056 | Apr 07, 2015, 04:38 PM |
| ZSEBO KRISZTINA M | Chief Executive Officer | Apr 06, 2015 | Sale | $18.20 | 47,931 | 872,283 | 9,754 | Apr 07, 2015, 04:38 PM |
| LABA REBECQUE J | VP, Corporate Operations | Apr 02, 2015 | Option Exercise | $1.75 | 11,012 | 19,296 | 13,907 | Apr 03, 2015, 04:12 PM |
| LABA REBECQUE J | VP, Corporate Operations | Apr 02, 2015 | Sale | $17.30 | 11,012 | 190,453 | 3,907 | Apr 03, 2015, 04:12 PM |
| TAKEYA RYAN K | VP, Manufacturing | Apr 01, 2015 | Option Exercise | $1.12 | 4,444 | 4,977 | 5,876 | Apr 03, 2015, 04:09 PM |
| TAKEYA RYAN K | VP, Manufacturing | Apr 01, 2015 | Sale | $19.13 | 4,444 | 85,014 | 1,432 | Apr 03, 2015, 04:09 PM |
| ZSEBO KRISZTINA M | Chief Executive Officer | Mar 09, 2015 | Option Exercise | $2.07 | 47,931 | 99,290 | 51,056 | Mar 09, 2015, 09:03 PM |
| ZSEBO KRISZTINA M | Chief Executive Officer | Mar 09, 2015 | Sale | $24.80 | 47,931 | 1,188,505 | 9,754 | Mar 09, 2015, 09:03 PM |
| Honig Peter | Director | Mar 05, 2015 | Option Exercise | $11.30 | 4,700 | 53,110 | 4,700 | Mar 09, 2015, 08:58 PM |
| Honig Peter | Director | Mar 06, 2015 | Option Exercise | $9.58 | 5,000 | 47,900 | 5,000 | Mar 09, 2015, 08:58 PM |
| Honig Peter | Director | Mar 05, 2015 | Sale | $22.40 | 4,700 | 105,288 | 2,200 | Mar 09, 2015, 08:58 PM |
| Honig Peter | Director | Mar 06, 2015 | Sale | $25.00 | 5,000 | 125,000 | 0 | Mar 09, 2015, 08:58 PM |
| LABA REBECQUE J | VP, Corporate Operations | Mar 06, 2015 | Option Exercise | $3.09 | 14,000 | 43,200 | 16,895 | Mar 09, 2015, 08:42 PM |
| LABA REBECQUE J | VP, Corporate Operations | Mar 06, 2015 | Sale | $23.06 | 14,000 | 322,820 | 6,895 | Mar 09, 2015, 08:42 PM |
| TAKEYA RYAN K | VP, Manufacturing | Mar 02, 2015 | Option Exercise | $1.12 | 7,777 | 8,710 | 9,209 | Mar 03, 2015, 09:13 PM |
| TAKEYA RYAN K | VP, Manufacturing | Mar 02, 2015 | Sale | $18.48 | 7,777 | 143,719 | 1,432 | Mar 03, 2015, 09:13 PM |
| LABA REBECQUE J | VP, Corporate Operations | Feb 06, 2015 | Option Exercise | $3.09 | 14,000 | 43,200 | 16,895 | Feb 10, 2015, 06:19 PM |
| LABA REBECQUE J | VP, Corporate Operations | Feb 06, 2015 | Sale | $16.08 | 14,000 | 225,120 | 6,895 | Feb 10, 2015, 06:19 PM |
| ZSEBO KRISZTINA M | Chief Executive Officer | Feb 09, 2015 | Option Exercise | $2.07 | 47,931 | 99,290 | 51,056 | Feb 10, 2015, 06:15 PM |
| ZSEBO KRISZTINA M | Chief Executive Officer | Feb 09, 2015 | Sale | $15.86 | 47,931 | 760,303 | 9,754 | Feb 10, 2015, 06:15 PM |
| TAKEYA RYAN K | VP, Manufacturing | Feb 02, 2015 | Option Exercise | $1.12 | 7,777 | 8,710 | 9,209 | Feb 03, 2015, 06:21 PM |
| TAKEYA RYAN K | VP, Manufacturing | Feb 02, 2015 | Sale | $16.35 | 7,777 | 127,154 | 1,432 | Feb 03, 2015, 06:21 PM |
| RUDY JEFFREY J | VP, Clinical Operations | Jan 09, 2015 | Option Exercise | $1.12 | 10,000 | 11,200 | 11,024 | Jan 12, 2015, 06:28 PM |
| RUDY JEFFREY J | VP, Clinical Operations | Jan 09, 2015 | Sale | $18.51 | 10,000 | 185,100 | 1,024 | Jan 12, 2015, 06:28 PM |
| ZSEBO KRISZTINA M | Chief Executive Officer | Jan 06, 2015 | Option Exercise | $1.12 | 41,302 | 46,258 | 44,427 | Jan 08, 2015, 06:43 PM |
| ZSEBO KRISZTINA M | Chief Executive Officer | Jan 06, 2015 | Sale | $17.51 | 41,302 | 723,198 | 3,125 | Jan 08, 2015, 06:43 PM |
| LABA REBECQUE J | VP, Corporate Operations | Jan 07, 2015 | Option Exercise | $1.12 | 20,000 | 22,400 | 22,895 | Jan 08, 2015, 06:42 PM |
| LABA REBECQUE J | VP, Corporate Operations | Jan 07, 2015 | Sale | $17.30 | 20,000 | 346,000 | 2,895 | Jan 08, 2015, 06:42 PM |
| TAKEYA RYAN K | VP, Manufacturing | Jan 02, 2015 | Option Exercise | $1.12 | 7,777 | 8,710 | 9,209 | Jan 05, 2015, 08:44 PM |
| TAKEYA RYAN K | VP, Manufacturing | Jan 02, 2015 | Sale | $19.88 | 7,777 | 154,607 | 1,432 | Jan 05, 2015, 08:44 PM |
| ZSEBO KRISZTINA M | Chief Executive Officer | Dec 09, 2014 | Option Exercise | $1.12 | 41,302 | 46,258 | 42,833 | Dec 10, 2014, 07:07 PM |
| ZSEBO KRISZTINA M | Chief Executive Officer | Dec 09, 2014 | Sale | $15.00 | 41,302 | 619,530 | 1,531 | Dec 10, 2014, 07:07 PM |
| RUDY JEFFREY J | VP, Clinical Operations | Dec 09, 2014 | Option Exercise | $1.12 | 10,000 | 11,200 | 10,414 | Dec 10, 2014, 06:43 PM |
| RUDY JEFFREY J | VP, Clinical Operations | Dec 09, 2014 | Sale | $15.00 | 10,000 | 150,000 | 414 | Dec 10, 2014, 06:43 PM |
| LABA REBECQUE J | VP, Finance and Administration | Dec 05, 2014 | Option Exercise | $1.12 | 20,000 | 22,400 | 20,691 | Dec 08, 2014, 06:42 PM |
| LABA REBECQUE J | VP, Finance and Administration | Dec 05, 2014 | Sale | $12.77 | 20,000 | 255,400 | 691 | Dec 08, 2014, 06:42 PM |
| TAKEYA RYAN K | VP, Manufacturing | Dec 01, 2014 | Option Exercise | $1.12 | 7,777 | 8,710 | 8,354 | Dec 02, 2014, 07:01 PM |
| TAKEYA RYAN K | VP, Manufacturing | Dec 01, 2014 | Sale | $12.01 | 7,777 | 93,402 | 577 | Dec 02, 2014, 07:01 PM |
| RUDY JEFFREY J | VP, Clinical Operations | Nov 14, 2014 | Option Exercise | $1.12 | 18,000 | 20,160 | 18,000 | Nov 18, 2014, 04:05 PM |
| RUDY JEFFREY J | VP, Clinical Operations | Nov 14, 2014 | Sale | $11.67 | 18,000 | 210,060 | 0 | Nov 18, 2014, 04:05 PM |
| Foley Todd | Director | Feb 04, 2014 | Option Exercise | $8.00 | 11,370 | 90,960 | 955,167 | Feb 06, 2014, 04:30 PM |
| Foley Todd | Director | Feb 04, 2014 | Buy | $8.00 | 111,608 | 892,864 | 1,066,775 | Feb 06, 2014, 04:30 PM |
| WIKLUND FREDRIK | VP Corp Dvlpmnt & Invs Rltns | Feb 04, 2014 | Buy | $8.00 | 20,000 | 160,000 | 20,000 | Feb 06, 2014, 03:54 PM |
| PFIZER INC | 10% Owner | Feb 04, 2014 | Option Exercise | $8.00 | 23,145 | 185,160 | 1,567,542 | Feb 06, 2014, 03:53 PM |
| PFIZER INC | 10% Owner | Feb 04, 2014 | Buy | $8.00 | 227,261 | 1,818,088 | 1,794,803 | Feb 06, 2014, 03:53 PM |
| Novartis Bioventures Ltd | 10% Owner | Feb 04, 2014 | Option Exercise | $8.00 | 16,537 | 132,296 | 1,389,335 | Feb 06, 2014, 03:52 PM |
| Novartis Bioventures Ltd | 10% Owner | Feb 04, 2014 | Buy | $8.00 | 162,386 | 1,299,088 | 1,551,721 | Feb 06, 2014, 03:52 PM |
| NARACHI MICHAEL | Director | Feb 04, 2014 | Buy | $8.00 | 62,500 | 500,000 | 62,500 | Feb 06, 2014, 03:50 PM |
| Lundbeckfond Invest A/S | 10% Owner | Feb 04, 2014 | Option Exercise | $8.00 | 18,605 | 148,840 | 1,563,002 | Feb 06, 2014, 03:47 PM |
| Lundbeckfond Invest A/S | 10% Owner | Feb 04, 2014 | Buy | $8.00 | 182,681 | 1,461,448 | 1,745,683 | Feb 06, 2014, 03:47 PM |
| Kordel Johan | Director | Feb 04, 2014 | Option Exercise | $8.00 | 18,605 | 148,840 | 1,563,002 | Feb 06, 2014, 03:44 PM |
| Kordel Johan | Director | Feb 04, 2014 | Buy | $8.00 | 182,681 | 1,461,448 | 1,745,683 | Feb 06, 2014, 03:44 PM |
| Funder Joshua | Director | Feb 04, 2014 | Option Exercise | $8.00 | 23,145 | 185,160 | 966,943 | Feb 06, 2014, 03:43 PM |
| Funder Joshua | Director | Feb 04, 2014 | Buy | $8.00 | 227,261 | 1,818,088 | 1,194,204 | Feb 06, 2014, 03:43 PM |
| Enterprise Partners Management LLC | 10% Owner | Feb 04, 2014 | Option Exercise | $8.00 | 13,553 | 108,424 | 1,817,101 | Feb 06, 2014, 03:41 PM |
| Enterprise Partners Management LLC | 10% Owner | Feb 04, 2014 | Buy | $8.00 | 133,083 | 1,064,664 | 1,950,184 | Feb 06, 2014, 03:41 PM |
Load More Insider Transactions
Buy
Sale
Option Exercise
| Owner | Relationship | Date | Value($) |
| KAYNE RICHARD A | 10% Owner | 10/31/2023 | 37,880 |
| KAYNE RICHARD A | 10% Owner | 11/02/2023 | 6,966 |
| KAYNE RICHARD A | 10% Owner | 11/01/2023 | 27,970 |
| KAWAS LEEN | 10% Owner | 10/31/2023 | 6,375 |
| Mayer Eldon C. III | Ex VP & Chief Commerc. Officer | 03/17/2023 | 4,704 |
| Dietz Thomas John | Director | 01/23/2023 | 71,580 |
| Murray Christine | Director | 12/29/2022 | 6,104 |
| Dietz Thomas John | Director | 12/22/2022 | 26,303 |
| Glenn Jeffrey S | Director | 12/22/2022 | 127,950 |
| Apelian David | Director | 08/16/2022 | 49,030 |
| Ryali Sriram | Chief Financial Officer | 03/14/2022 | 12,683 |
| Mayer Eldon C. III | Ex VP & Chief Commerc. Officer | 03/14/2022 | 9,275 |
| Mayer Eldon C. III | Ex VP & Chief Commerc. Officer | 01/07/2022 | 7,722 |
| Dietz Thomas John | Director | 04/09/2021 | 21,220 |
| Loh Evan | Director | 03/15/2021 | 20,280 |
| Mayer Eldon C. III | Ex VP & Chief Commerc. Officer | 01/08/2021 | 19,739 |
| Glenn Jeffrey S | Director | 08/12/2020 | 57,103 |
| Glenn Jeffrey S | Director | 08/11/2020 | 57,463 |
| Dietz Thomas John | Director | 03/16/2020 | 4,950 |
| Glenn Jeffrey S | Director | 03/16/2020 | 150,813 |
| Shaffer James P | Chief Business Officer | 03/05/2020 | 10,965 |
| Ryali Sriram | Chief Financial Officer | 03/05/2020 | 1,674 |
| Patton Stephana Eilene | See Remarks | 03/05/2020 | 5,994 |
| Cory David A | President and CEO | 03/05/2020 | 10,965 |
| Mayer Eldon C. III | Ex VP & Chief Commerc. Officer | 01/24/2020 | 67,603 |
| Dietz Thomas John | Director | 01/10/2020 | 55,760 |
| Shaffer James P | Chief Business Officer | 09/05/2019 | 11,921 |
| Ryali Sriram | Chief Financial Officer | 09/05/2019 | 1,396 |
| Cory David A | President and CEO | 09/05/2019 | 11,921 |
| Cory David A | President and CEO | 02/04/2019 | 3,862 |
| Dietz Thomas John | Director | 04/23/2019 | 55,495 |
| Ryali Sriram | Chief Financial Officer | 04/22/2019 | 13,853 |
| Dietz Thomas John | Director | 04/22/2019 | 55,250 |
| Patton Stephana Eilene | See Remarks | 04/22/2019 | 11,030 |
| Shaffer James P | Chief Business Officer | 03/05/2019 | 11,921 |
| Shaffer James P | Chief Business Officer | 09/05/2018 | 11,921 |
| Shaffer James P | Chief Business Officer | 03/05/2018 | 12,049 |
| Shaffer James P | Chief Business Officer | 09/05/2017 | 14,854 |
| Shaffer James P | Chief Business Officer | 03/06/2017 | 10,671 |
| Cory David A | President and CEO | 09/05/2018 | 11,921 |
| Cory David A | President and CEO | 03/05/2018 | 12,049 |
| Cory David A | President and CEO | 09/05/2017 | 14,854 |
| Cory David A | President and CEO | 03/06/2017 | 10,868 |
| Cory David A | President and CEO | 03/05/2019 | 11,921 |
| Cory David A | President and CEO | 02/04/2019 | 3,208 |
| Dietz Thomas John | Director | 12/20/2018 | 49,900 |
| Dietz Thomas John | Director | 12/06/2018 | 56,300 |
| Mayer Eldon C. III | Director | 11/29/2018 | 40,840 |
| Mayer Eldon C. III | Director | 11/28/2001 | 60,447 |
| Mayer Eldon C. III | Director | 11/27/2018 | 74,407 |
| Mayer Eldon C. III | Director | 11/26/2018 | 73,143 |
| INTERWEST PARTNERS X LP | 10% Owner | 10/18/2018 | 2,862,321 |
| Quan Joanne | Chief Medical Officer | 04/02/2018 | 8,240 |
| Quan Joanne | Chief Medical Officer | 04/02/2018 | 40,000 |
| Glenn Jeffrey S | Director | 09/01/2017 | 142,950 |
| Glenn Jeffrey S | Director | 11/18/2016 | 5,934 |
| Glenn Jeffrey S | Director | 11/17/2016 | 190,950 |
| Vivo Ventures VI, LLC | 10% Owner | 08/18/2016 | 21,824 |
| Vivo Ventures VI, LLC | 10% Owner | 08/18/2016 | 2,978,176 |
| Cory David A | President and CEO | 08/18/2016 | 24,523 |
| Shaffer James P | Chief Business Officer | 08/18/2016 | 49,062 |
| WELCH JAMES H | Chief Financial Officer | 06/22/2016 | 9,897 |
| WELCH JAMES H | Chief Financial Officer | 06/20/2016 | 39,592 |
| Shaffer James P | Chief Business Officer | 06/13/2016 | 27,718 |
| Shaffer James P | Chief Business Officer | 05/23/2016 | 14,893 |
| Shaffer James P | Chief Business Officer | 05/19/2016 | 9,760 |
| ZSEBO KRISZTINA M | Chief Executive Officer | 04/06/2015 | 99,290 |
| ZSEBO KRISZTINA M | Chief Executive Officer | 04/06/2015 | 872,283 |
| LABA REBECQUE J | VP, Corporate Operations | 04/02/2015 | 19,296 |
| LABA REBECQUE J | VP, Corporate Operations | 04/02/2015 | 190,453 |
| TAKEYA RYAN K | VP, Manufacturing | 04/01/2015 | 4,977 |
| TAKEYA RYAN K | VP, Manufacturing | 04/01/2015 | 85,014 |
| ZSEBO KRISZTINA M | Chief Executive Officer | 03/09/2015 | 99,290 |
| ZSEBO KRISZTINA M | Chief Executive Officer | 03/09/2015 | 1,188,505 |
| Honig Peter | Director | 03/05/2015 | 53,110 |
| Honig Peter | Director | 03/06/2015 | 47,900 |
| Honig Peter | Director | 03/05/2015 | 105,288 |
| Honig Peter | Director | 03/06/2015 | 125,000 |
| LABA REBECQUE J | VP, Corporate Operations | 03/06/2015 | 43,200 |
| LABA REBECQUE J | VP, Corporate Operations | 03/06/2015 | 322,820 |
| TAKEYA RYAN K | VP, Manufacturing | 03/02/2015 | 8,710 |
| TAKEYA RYAN K | VP, Manufacturing | 03/02/2015 | 143,719 |
| LABA REBECQUE J | VP, Corporate Operations | 02/06/2015 | 43,200 |
| LABA REBECQUE J | VP, Corporate Operations | 02/06/2015 | 225,120 |
| ZSEBO KRISZTINA M | Chief Executive Officer | 02/09/2015 | 99,290 |
| ZSEBO KRISZTINA M | Chief Executive Officer | 02/09/2015 | 760,303 |
| TAKEYA RYAN K | VP, Manufacturing | 02/02/2015 | 8,710 |
| TAKEYA RYAN K | VP, Manufacturing | 02/02/2015 | 127,154 |
| RUDY JEFFREY J | VP, Clinical Operations | 01/09/2015 | 11,200 |
| RUDY JEFFREY J | VP, Clinical Operations | 01/09/2015 | 185,100 |
| ZSEBO KRISZTINA M | Chief Executive Officer | 01/06/2015 | 46,258 |
| ZSEBO KRISZTINA M | Chief Executive Officer | 01/06/2015 | 723,198 |
| LABA REBECQUE J | VP, Corporate Operations | 01/07/2015 | 22,400 |
| LABA REBECQUE J | VP, Corporate Operations | 01/07/2015 | 346,000 |
| TAKEYA RYAN K | VP, Manufacturing | 01/02/2015 | 8,710 |
| TAKEYA RYAN K | VP, Manufacturing | 01/02/2015 | 154,607 |
| ZSEBO KRISZTINA M | Chief Executive Officer | 12/09/2014 | 46,258 |
| ZSEBO KRISZTINA M | Chief Executive Officer | 12/09/2014 | 619,530 |
| RUDY JEFFREY J | VP, Clinical Operations | 12/09/2014 | 11,200 |
| RUDY JEFFREY J | VP, Clinical Operations | 12/09/2014 | 150,000 |
| LABA REBECQUE J | VP, Finance and Administration | 12/05/2014 | 22,400 |
| LABA REBECQUE J | VP, Finance and Administration | 12/05/2014 | 255,400 |
| TAKEYA RYAN K | VP, Manufacturing | 12/01/2014 | 8,710 |
| TAKEYA RYAN K | VP, Manufacturing | 12/01/2014 | 93,402 |
| RUDY JEFFREY J | VP, Clinical Operations | 11/14/2014 | 20,160 |
| RUDY JEFFREY J | VP, Clinical Operations | 11/14/2014 | 210,060 |
| Foley Todd | Director | 02/04/2014 | 90,960 |
| Foley Todd | Director | 02/04/2014 | 892,864 |
| WIKLUND FREDRIK | VP Corp Dvlpmnt & Invs Rltns | 02/04/2014 | 160,000 |
| PFIZER INC | 10% Owner | 02/04/2014 | 185,160 |
| PFIZER INC | 10% Owner | 02/04/2014 | 1,818,088 |
| Novartis Bioventures Ltd | 10% Owner | 02/04/2014 | 132,296 |
| Novartis Bioventures Ltd | 10% Owner | 02/04/2014 | 1,299,088 |
| NARACHI MICHAEL | Director | 02/04/2014 | 500,000 |
| Lundbeckfond Invest A/S | 10% Owner | 02/04/2014 | 148,840 |
| Lundbeckfond Invest A/S | 10% Owner | 02/04/2014 | 1,461,448 |
| Kordel Johan | Director | 02/04/2014 | 148,840 |
| Kordel Johan | Director | 02/04/2014 | 1,461,448 |
| Funder Joshua | Director | 02/04/2014 | 185,160 |
| Funder Joshua | Director | 02/04/2014 | 1,818,088 |
| Enterprise Partners Management LLC | 10% Owner | 02/04/2014 | 108,424 |
| Enterprise Partners Management LLC | 10% Owner | 02/04/2014 | 1,064,664 |
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