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INSIDER TRANSACTIONS FOR
| Owner | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| Ashar Bhavesh | Chief Commercial Officer | Apr 01, 2024 | Option Exercise | $47.62 | 1,824 | 86,859 | 56,330 | Apr 03, 2024, 04:01 PM |
| Pichl Daniel | Chief People Officer | Feb 16, 2024 | Option Exercise | $27.64 | 15,000 | 414,600 | 60,212 | Feb 20, 2024, 06:56 PM |
| Pichl Daniel | Chief People Officer | Feb 16, 2024 | Sale | $50.10 | 15,000 | 751,549 | 45,212 | Feb 20, 2024, 06:56 PM |
| Ashar Bhavesh | Chief Commercial Officer | Feb 05, 2024 | Sale | $49.32 | 4,834 | 238,435 | 58,154 | Feb 05, 2024, 09:24 PM |
| Ashar Bhavesh | Chief Commercial Officer | Feb 02, 2024 | Sale | $44.37 | 3,222 | 142,976 | 65,121 | Feb 05, 2024, 09:24 PM |
| Pichl Daniel | Chief People Officer | Feb 02, 2024 | Option Exercise | $27.64 | 16,250 | 449,150 | 71,393 | Feb 05, 2024, 09:23 PM |
| Pichl Daniel | Chief People Officer | Feb 02, 2024 | Sale | $44.32 | 26,181 | 1,160,362 | 62,127 | Feb 05, 2024, 09:23 PM |
| Weinstein Herschel S | General Counsel & Secretary | Jan 05, 2024 | Option Exercise | $37.96 | 2,324 | 88,219 | 54,662 | Jan 08, 2024, 09:13 PM |
| Weinstein Herschel S | General Counsel & Secretary | Jan 08, 2024 | Option Exercise | $41.53 | 2,423 | 100,627 | 52,239 | Jan 08, 2024, 09:13 PM |
| Smith L. Mary | Chief Development Officer | Jan 08, 2024 | Option Exercise | $41.53 | 3,535 | 146,809 | 233,363 | Jan 08, 2024, 09:13 PM |
| Smith L. Mary | Chief Development Officer | Jan 05, 2024 | Option Exercise | $37.96 | 2,197 | 83,398 | 236,898 | Jan 08, 2024, 09:13 PM |
| Islam Saqib | Chief Executive Officer | Jan 08, 2024 | Option Exercise | $41.53 | 17,904 | 743,553 | 256,264 | Jan 08, 2024, 09:12 PM |
| Islam Saqib | Chief Executive Officer | Jan 05, 2024 | Option Exercise | $37.96 | 12,885 | 489,115 | 274,168 | Jan 08, 2024, 09:12 PM |
| Pichl Daniel | Chief People Officer | Jan 08, 2024 | Option Exercise | $41.53 | 1,405 | 58,350 | 55,143 | Jan 08, 2024, 09:12 PM |
| Pichl Daniel | Chief People Officer | Jan 05, 2024 | Option Exercise | $37.96 | 1,574 | 59,749 | 56,548 | Jan 08, 2024, 09:12 PM |
| Perier Francis I Jr | Chief Financial Officer | Jan 08, 2024 | Option Exercise | $41.53 | 3,215 | 133,519 | 59,253 | Jan 08, 2024, 09:11 PM |
| Perier Francis I Jr | Chief Financial Officer | Jan 05, 2024 | Option Exercise | $37.96 | 2,151 | 81,652 | 62,468 | Jan 08, 2024, 09:11 PM |
| Nofi Michael | Chief Accounting Officer | Jan 08, 2024 | Option Exercise | $41.53 | 1,063 | 44,146 | 28,727 | Jan 08, 2024, 09:11 PM |
| Nofi Michael | Chief Accounting Officer | Jan 05, 2024 | Option Exercise | $37.96 | 1,169 | 44,375 | 29,790 | Jan 08, 2024, 09:11 PM |
| Edris Badreddin | Chief Operating Officer | Jan 08, 2024 | Option Exercise | $41.53 | 5,466 | 227,003 | 269,600 | Jan 08, 2024, 09:09 PM |
| Edris Badreddin | Chief Operating Officer | Jan 05, 2024 | Option Exercise | $37.96 | 4,469 | 169,643 | 275,066 | Jan 08, 2024, 09:09 PM |
| Cassidy James | Chief Medical Officer | Jan 08, 2024 | Option Exercise | $41.53 | 1,093 | 45,392 | 76,416 | Jan 08, 2024, 09:07 PM |
| Cassidy James | Chief Medical Officer | Jan 05, 2024 | Option Exercise | $37.96 | 2,357 | 89,472 | 77,509 | Jan 08, 2024, 09:07 PM |
| Ashar Bhavesh | Chief Commercial Officer | Jan 08, 2024 | Option Exercise | $41.53 | 1,449 | 60,177 | 66,210 | Jan 08, 2024, 09:06 PM |
| Ashar Bhavesh | Chief Commercial Officer | Jan 05, 2024 | Option Exercise | $37.96 | 2,507 | 95,166 | 67,659 | Jan 08, 2024, 09:06 PM |
| Cassidy James | Chief Medical Officer | Sep 01, 2023 | Option Exercise | $30.33 | 1,292 | 39,186 | 51,658 | Sep 08, 2023, 04:05 PM |
| Hambleton Julie | Director | Jul 19, 2023 | Sale | $29.31 | 2,418 | 70,876 | 4,648 | Jul 21, 2023, 04:13 PM |
| Hambleton Julie | Director | Jun 20, 2023 | Sale | $26.92 | 2,400 | 64,603 | 7,066 | Jun 22, 2023, 04:06 PM |
| Ashar Bhavesh | Chief Commercial Officer | Apr 03, 2023 | Option Exercise | $25.25 | 1,375 | 34,719 | 43,721 | Apr 05, 2023, 04:46 PM |
| Schwartz Jeffrey Lawrence | Director | Mar 16, 2023 | Sale | $28.50 | 1,750,000 | 49,875,000 | 3,081,307 | Mar 20, 2023, 05:00 PM |
| Hambleton Julie | Director | Mar 15, 2023 | Sale | $31.50 | 1,106 | 34,841 | 4,818 | Mar 16, 2023, 04:31 PM |
| Pichl Daniel | Chief People Officer | Jan 26, 2023 | Sale | $31.00 | 858 | 26,598 | 35,203 | Jan 27, 2023, 04:30 PM |
| Nofi Michael | Chief Accounting Officer | Jan 07, 2023 | Option Exercise | $26.41 | 409 | 10,802 | 16,855 | Jan 10, 2023, 04:08 PM |
| Islam Saqib | Chief Executive Officer | Jan 07, 2023 | Option Exercise | $26.41 | 4,097 | 108,202 | 905,104 | Jan 10, 2023, 04:07 PM |
| Edris Badreddin | Chief Operating Officer | Jan 07, 2023 | Option Exercise | $26.41 | 1,483 | 39,166 | 237,223 | Jan 10, 2023, 04:05 PM |
| Pichl Daniel | Chief People Officer | Jan 07, 2023 | Option Exercise | $26.41 | 546 | 14,420 | 36,061 | Jan 10, 2023, 04:02 PM |
| Perier Francis I Jr | Chief Financial Officer | Jan 07, 2023 | Option Exercise | $26.41 | 1,090 | 28,787 | 43,463 | Jan 10, 2023, 04:02 PM |
| Smith L. Mary | Chief Development Officer | Jan 07, 2023 | Option Exercise | $26.41 | 1,068 | 28,206 | 212,219 | Jan 10, 2023, 04:01 PM |
| Weinstein Herschel S | General Counsel & Secretary | Jan 07, 2023 | Option Exercise | $26.41 | 909 | 24,007 | 35,830 | Jan 10, 2023, 04:01 PM |
| Perier Francis I Jr | Chief Financial Officer | Jan 06, 2023 | Option Exercise | $27.52 | 2,374 | 65,332 | 44,553 | Jan 09, 2023, 05:01 PM |
| Islam Saqib | Chief Executive Officer | Jan 06, 2023 | Option Exercise | $27.52 | 8,400 | 231,168 | 909,201 | Jan 09, 2023, 05:01 PM |
| Edris Badreddin | Chief Operating Officer | Jan 06, 2023 | Option Exercise | $27.52 | 3,326 | 91,532 | 238,706 | Jan 09, 2023, 05:01 PM |
| Cassidy James | Chief Medical Officer | Jan 06, 2023 | Option Exercise | $27.52 | 1,263 | 34,758 | 47,230 | Jan 09, 2023, 05:00 PM |
| Smith L. Mary | Chief Development Officer | Jan 06, 2023 | Option Exercise | $27.52 | 2,452 | 67,479 | 213,287 | Jan 09, 2023, 05:00 PM |
| Nofi Michael | Chief Accounting Officer | Jan 06, 2023 | Option Exercise | $27.52 | 783 | 21,548 | 17,264 | Jan 09, 2023, 05:00 PM |
| Ashar Bhavesh | Chief Commercial Officer | Jan 06, 2023 | Option Exercise | $27.52 | 1,665 | 45,821 | 45,096 | Jan 09, 2023, 05:00 PM |
| Weinstein Herschel S | General Counsel & Secretary | Jan 06, 2023 | Option Exercise | $27.52 | 1,782 | 49,041 | 36,739 | Jan 09, 2023, 04:59 PM |
| Pichl Daniel | Chief People Officer | Jan 06, 2023 | Option Exercise | $27.52 | 1,719 | 47,307 | 36,607 | Jan 09, 2023, 04:59 PM |
| Ashar Bhavesh | Chief Commercial Officer | Apr 01, 2022 | Option Exercise | $56.90 | 1,464 | 83,302 | 24,098 | Oct 13, 2022, 04:03 PM |
| ORBIMED ADVISORS LLC | 10% Owner | Sep 12, 2022 | Sale | $31.96 | 153,897 | 4,919,148 | 5,629,842 | Sep 14, 2022, 04:24 PM |
| ORBIMED ADVISORS LLC | 10% Owner | Aug 09, 2022 | Sale | $37.47 | 69,568 | 2,606,713 | 5,753,739 | Aug 10, 2022, 04:22 PM |
| ORBIMED ADVISORS LLC | 10% Owner | Aug 08, 2022 | Sale | $38.33 | 205,000 | 7,857,650 | 5,823,307 | Aug 10, 2022, 04:22 PM |
| Smith L. Mary | Chief Development Officer | Jul 18, 2022 | Option Exercise | $28.47 | 1,551 | 44,157 | 193,076 | Jul 20, 2022, 06:02 PM |
| Burgess Michael F. | Head of Research & Development | Jul 18, 2022 | Option Exercise | $28.47 | 3,103 | 88,342 | 49,584 | Jul 20, 2022, 06:02 PM |
| Burgess Michael F. | Head of Research & Development | Jun 01, 2022 | Option Exercise | $19.61 | 2,672 | 52,398 | 40,502 | Jul 05, 2022, 05:29 PM |
| Nofi Michael | Chief Accounting Officer | Jan 07, 2022 | Option Exercise | $56.06 | 414 | 23,209 | 8,334 | Jan 14, 2022, 04:59 PM |
| Pichl Daniel | Chief People Officer | Jan 07, 2022 | Option Exercise | $56.06 | 631 | 35,374 | 21,667 | Jan 14, 2022, 04:59 PM |
| Weinstein Herschel S | General Counsel & Secretary | Jan 07, 2022 | Option Exercise | $56.06 | 966 | 54,154 | 19,096 | Jan 14, 2022, 04:58 PM |
| Perier Francis I Jr | Chief Financial Officer | Jan 07, 2022 | Option Exercise | $56.06 | 1,307 | 73,270 | 27,502 | Jan 14, 2022, 04:58 PM |
| Smith L. Mary | Chief Development Officer | Jan 07, 2022 | Option Exercise | $56.06 | 1,181 | 66,207 | 188,535 | Jan 14, 2022, 04:58 PM |
| Edris Badreddin | Chief Operating Officer | Jan 07, 2022 | Option Exercise | $56.06 | 1,852 | 103,823 | 325,813 | Jan 14, 2022, 04:58 PM |
| Islam Saqib | Chief Executive Officer | Jan 07, 2022 | Option Exercise | $56.06 | 3,996 | 224,016 | 853,592 | Jan 14, 2022, 04:57 PM |
| Weinstein Herschel S | General Counsel & Secretary | Jan 07, 2022 | Option Exercise | $56.06 | 1,323 | 74,167 | 18,739 | Jan 11, 2022, 04:04 PM |
| Pichl Daniel | Chief People Officer | Jan 07, 2022 | Option Exercise | $56.06 | 842 | 47,203 | 21,456 | Jan 11, 2022, 04:04 PM |
| Francis Perier I Jr | Chief Financial Officer | Jan 07, 2022 | Option Exercise | $56.06 | 1,846 | 103,487 | 26,963 | Jan 11, 2022, 04:04 PM |
| Nofi Michael | Chief Accounting Officer | Jan 07, 2022 | Option Exercise | $56.06 | 567 | 31,786 | 8,181 | Jan 11, 2022, 04:03 PM |
| Smith L. Mary | Chief Development Officer | Jan 07, 2022 | Option Exercise | $56.06 | 1,772 | 99,338 | 187,944 | Jan 11, 2022, 04:03 PM |
| Islam Saqib | Chief Executive Officer | Jan 07, 2022 | Option Exercise | $56.06 | 5,893 | 330,362 | 851,695 | Jan 11, 2022, 04:02 PM |
| Edris Badreddin | Chief Operating Officer | Jan 07, 2022 | Option Exercise | $56.06 | 2,531 | 141,888 | 325,134 | Jan 11, 2022, 04:02 PM |
| Islam Saqib | Chief Executive Officer | Oct 20, 2021 | Sale | $58.67 | 10,083 | 591,527 | 779,218 | Oct 20, 2021, 07:14 PM |
| Islam Saqib | Chief Executive Officer | Oct 19, 2021 | Sale | $58.81 | 14,077 | 827,873 | 769,135 | Oct 19, 2021, 07:27 PM |
| Islam Saqib | Chief Executive Officer | Oct 18, 2021 | Sale | $58.59 | 38,340 | 2,246,505 | 783,212 | Oct 19, 2021, 07:27 PM |
| Smith L. Mary | Chief Development Officer | Oct 13, 2021 | Option Exercise | $2.30 | 10,000 | 23,000 | 177,511 | Oct 13, 2021, 08:24 PM |
| Smith L. Mary | Chief Development Officer | Oct 13, 2021 | Sale | $55.97 | 10,000 | 559,675 | 167,511 | Oct 13, 2021, 08:24 PM |
| Pichl Daniel | Chief People Officer | Sep 08, 2021 | Option Exercise | $43.10 | 2,320 | 99,992 | 9,236 | Sep 09, 2021, 05:15 PM |
| Bain Capital Life Sciences Investors, LLC | 10% Owner | Aug 10, 2021 | Sale | $70.25 | 1,000,000 | 70,250,000 | 4,831,307 | Aug 12, 2021, 08:38 PM |
| Islam Saqib | Chief Executive Officer | Jul 20, 2021 | Sale | $77.68 | 18,572 | 1,442,751 | 821,552 | Jul 20, 2021, 07:34 PM |
| Islam Saqib | Chief Executive Officer | Jul 19, 2021 | Sale | $76.09 | 43,928 | 3,342,437 | 840,124 | Jul 20, 2021, 07:34 PM |
| Smith L. Mary | Chief Development Officer | Jul 13, 2021 | Option Exercise | $2.30 | 10,000 | 23,000 | 177,511 | Jul 14, 2021, 04:28 PM |
| Smith L. Mary | Chief Development Officer | Jul 13, 2021 | Sale | $80.88 | 10,000 | 808,777 | 167,511 | Jul 14, 2021, 04:28 PM |
| ORBIMED ADVISORS LLC | 10% Owner | Jul 01, 2021 | Sale | $85.01 | 15,959 | 1,356,675 | 6,028,307 | Jul 06, 2021, 04:42 PM |
| Edris Badreddin | Chief Operating Officer | Jul 01, 2021 | Sale | $85.35 | 32,000 | 2,731,088 | 301,541 | Jul 01, 2021, 06:30 PM |
| ORBIMED ADVISORS LLC | 10% Owner | Jun 28, 2021 | Sale | $85.17 | 6,502 | 553,775 | 6,044,266 | Jun 30, 2021, 09:01 PM |
| ORBIMED ADVISORS LLC | 10% Owner | Jun 25, 2021 | Sale | $85.14 | 22,334 | 1,901,517 | 6,050,768 | Jun 25, 2021, 07:11 PM |
| ORBIMED ADVISORS LLC | 10% Owner | Jun 24, 2021 | Sale | $85.22 | 34,200 | 2,914,524 | 6,073,102 | Jun 25, 2021, 07:11 PM |
| ORBIMED ADVISORS LLC | 10% Owner | Jun 23, 2021 | Sale | $85.00 | 100 | 8,500 | 6,107,302 | Jun 25, 2021, 07:11 PM |
| SQUINTO STEPHEN P | Director | Apr 28, 2021 | Sale | $76.20 | 19,231 | 1,465,437 | 125,728 | Apr 28, 2021, 08:18 PM |
| SQUINTO STEPHEN P | Director | Apr 27, 2021 | Sale | $75.05 | 201 | 15,085 | 144,959 | Apr 28, 2021, 08:18 PM |
| Islam Saqib | Chief Executive Officer | Apr 20, 2021 | Sale | $66.39 | 24,075 | 1,598,279 | 884,052 | Apr 20, 2021, 06:51 PM |
| Islam Saqib | Chief Executive Officer | Apr 19, 2021 | Sale | $69.04 | 38,425 | 2,652,827 | 908,127 | Apr 20, 2021, 06:51 PM |
| SQUINTO STEPHEN P | Director | Apr 15, 2021 | Sale | $75.01 | 1,057 | 79,291 | 145,160 | Apr 19, 2021, 06:07 AM |
| SQUINTO STEPHEN P | Director | Apr 14, 2021 | Sale | $75.08 | 511 | 38,365 | 146,217 | Apr 19, 2021, 06:07 AM |
| Smith L. Mary | Chief Development Officer | Apr 13, 2021 | Option Exercise | $2.30 | 10,000 | 23,000 | 177,511 | Apr 13, 2021, 08:21 PM |
| Smith L. Mary | Chief Development Officer | Apr 13, 2021 | Sale | $68.07 | 10,000 | 680,723 | 167,511 | Apr 13, 2021, 08:21 PM |
| Bain Capital Life Sciences Investors, LLC | 10% Owner | Mar 09, 2021 | Sale | $71.50 | 1,450,000 | 103,675,000 | 5,831,307 | Mar 11, 2021, 04:30 PM |
| ORBIMED ADVISORS LLC | 10% Owner | Mar 01, 2021 | Sale | $83.19 | 1,220,000 | 101,491,803 | 6,186,307 | Mar 03, 2021, 06:55 PM |
| Edris Badreddin | Chief Operating Officer | Jan 25, 2021 | Sale | $84.07 | 32,000 | 2,690,281 | 261,542 | Jan 26, 2021, 04:31 PM |
| Smith L. Mary | Chief Development Officer | Jan 20, 2021 | Option Exercise | $2.23 | 10,000 | 22,267 | 177,511 | Jan 21, 2021, 04:31 PM |
| Smith L. Mary | Chief Development Officer | Jan 20, 2021 | Sale | $78.70 | 10,000 | 787,016 | 167,511 | Jan 21, 2021, 04:31 PM |
| Islam Saqib | Chief Executive Officer | Jan 20, 2021 | Sale | $78.75 | 2,199 | 173,180 | 1,222,997 | Jan 21, 2021, 04:30 PM |
| Islam Saqib | Chief Executive Officer | Jan 19, 2021 | Sale | $78.54 | 60,301 | 4,736,209 | 1,225,196 | Jan 21, 2021, 04:30 PM |
| Lewis-Hall Freda C | Director | Sep 17, 2019 | Buy | $18.00 | 50,000 | 900,000 | 4,593,847 | Sep 19, 2019, 07:12 PM |
| ORBIMED ADVISORS LLC | 10% Owner | Sep 17, 2019 | Buy | $18.00 | 275,000 | 4,950,000 | 7,406,307 | Sep 19, 2019, 07:12 PM |
| SQUINTO STEPHEN P | Director | Sep 17, 2019 | Buy | $18.00 | 275,000 | 4,950,000 | 7,406,307 | Sep 19, 2019, 07:12 PM |
| Bain Capital Life Sciences Investors, LLC | 10% Owner | Sep 17, 2019 | Buy | $18.00 | 150,000 | 2,700,000 | 7,281,307 | Sep 19, 2019, 07:05 PM |
| PFIZER INC | 10% Owner | Sep 17, 2019 | Buy | $18.00 | 50,000 | 900,000 | 4,593,847 | Sep 19, 2019, 04:19 PM |
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Sale
Option Exercise
| Owner | Relationship | Date | Value($) |
| Ashar Bhavesh | Chief Commercial Officer | 04/01/2024 | 86,859 |
| Pichl Daniel | Chief People Officer | 02/16/2024 | 414,600 |
| Pichl Daniel | Chief People Officer | 02/16/2024 | 751,549 |
| Ashar Bhavesh | Chief Commercial Officer | 02/05/2024 | 238,435 |
| Ashar Bhavesh | Chief Commercial Officer | 02/02/2024 | 142,976 |
| Pichl Daniel | Chief People Officer | 02/02/2024 | 449,150 |
| Pichl Daniel | Chief People Officer | 02/02/2024 | 1,160,362 |
| Weinstein Herschel S | General Counsel & Secretary | 01/05/2024 | 88,219 |
| Weinstein Herschel S | General Counsel & Secretary | 01/08/2024 | 100,627 |
| Smith L. Mary | Chief Development Officer | 01/08/2024 | 146,809 |
| Smith L. Mary | Chief Development Officer | 01/05/2024 | 83,398 |
| Islam Saqib | Chief Executive Officer | 01/08/2024 | 743,553 |
| Islam Saqib | Chief Executive Officer | 01/05/2024 | 489,115 |
| Pichl Daniel | Chief People Officer | 01/08/2024 | 58,350 |
| Pichl Daniel | Chief People Officer | 01/05/2024 | 59,749 |
| Perier Francis I Jr | Chief Financial Officer | 01/08/2024 | 133,519 |
| Perier Francis I Jr | Chief Financial Officer | 01/05/2024 | 81,652 |
| Nofi Michael | Chief Accounting Officer | 01/08/2024 | 44,146 |
| Nofi Michael | Chief Accounting Officer | 01/05/2024 | 44,375 |
| Edris Badreddin | Chief Operating Officer | 01/08/2024 | 227,003 |
| Edris Badreddin | Chief Operating Officer | 01/05/2024 | 169,643 |
| Cassidy James | Chief Medical Officer | 01/08/2024 | 45,392 |
| Cassidy James | Chief Medical Officer | 01/05/2024 | 89,472 |
| Ashar Bhavesh | Chief Commercial Officer | 01/08/2024 | 60,177 |
| Ashar Bhavesh | Chief Commercial Officer | 01/05/2024 | 95,166 |
| Cassidy James | Chief Medical Officer | 09/01/2023 | 39,186 |
| Hambleton Julie | Director | 07/19/2023 | 70,876 |
| Hambleton Julie | Director | 06/20/2023 | 64,603 |
| Ashar Bhavesh | Chief Commercial Officer | 04/03/2023 | 34,719 |
| Schwartz Jeffrey Lawrence | Director | 03/16/2023 | 49,875,000 |
| Hambleton Julie | Director | 03/15/2023 | 34,841 |
| Pichl Daniel | Chief People Officer | 01/26/2023 | 26,598 |
| Nofi Michael | Chief Accounting Officer | 01/07/2023 | 10,802 |
| Islam Saqib | Chief Executive Officer | 01/07/2023 | 108,202 |
| Edris Badreddin | Chief Operating Officer | 01/07/2023 | 39,166 |
| Pichl Daniel | Chief People Officer | 01/07/2023 | 14,420 |
| Perier Francis I Jr | Chief Financial Officer | 01/07/2023 | 28,787 |
| Smith L. Mary | Chief Development Officer | 01/07/2023 | 28,206 |
| Weinstein Herschel S | General Counsel & Secretary | 01/07/2023 | 24,007 |
| Perier Francis I Jr | Chief Financial Officer | 01/06/2023 | 65,332 |
| Islam Saqib | Chief Executive Officer | 01/06/2023 | 231,168 |
| Edris Badreddin | Chief Operating Officer | 01/06/2023 | 91,532 |
| Cassidy James | Chief Medical Officer | 01/06/2023 | 34,758 |
| Smith L. Mary | Chief Development Officer | 01/06/2023 | 67,479 |
| Nofi Michael | Chief Accounting Officer | 01/06/2023 | 21,548 |
| Ashar Bhavesh | Chief Commercial Officer | 01/06/2023 | 45,821 |
| Weinstein Herschel S | General Counsel & Secretary | 01/06/2023 | 49,041 |
| Pichl Daniel | Chief People Officer | 01/06/2023 | 47,307 |
| Ashar Bhavesh | Chief Commercial Officer | 04/01/2022 | 83,302 |
| ORBIMED ADVISORS LLC | 10% Owner | 09/12/2022 | 4,919,148 |
| ORBIMED ADVISORS LLC | 10% Owner | 08/09/2022 | 2,606,713 |
| ORBIMED ADVISORS LLC | 10% Owner | 08/08/2022 | 7,857,650 |
| Smith L. Mary | Chief Development Officer | 07/18/2022 | 44,157 |
| Burgess Michael F. | Head of Research & Development | 07/18/2022 | 88,342 |
| Burgess Michael F. | Head of Research & Development | 06/01/2022 | 52,398 |
| Nofi Michael | Chief Accounting Officer | 01/07/2022 | 23,209 |
| Pichl Daniel | Chief People Officer | 01/07/2022 | 35,374 |
| Weinstein Herschel S | General Counsel & Secretary | 01/07/2022 | 54,154 |
| Perier Francis I Jr | Chief Financial Officer | 01/07/2022 | 73,270 |
| Smith L. Mary | Chief Development Officer | 01/07/2022 | 66,207 |
| Edris Badreddin | Chief Operating Officer | 01/07/2022 | 103,823 |
| Islam Saqib | Chief Executive Officer | 01/07/2022 | 224,016 |
| Weinstein Herschel S | General Counsel & Secretary | 01/07/2022 | 74,167 |
| Pichl Daniel | Chief People Officer | 01/07/2022 | 47,203 |
| Francis Perier I Jr | Chief Financial Officer | 01/07/2022 | 103,487 |
| Nofi Michael | Chief Accounting Officer | 01/07/2022 | 31,786 |
| Smith L. Mary | Chief Development Officer | 01/07/2022 | 99,338 |
| Islam Saqib | Chief Executive Officer | 01/07/2022 | 330,362 |
| Edris Badreddin | Chief Operating Officer | 01/07/2022 | 141,888 |
| Islam Saqib | Chief Executive Officer | 10/20/2021 | 591,527 |
| Islam Saqib | Chief Executive Officer | 10/19/2021 | 827,873 |
| Islam Saqib | Chief Executive Officer | 10/18/2021 | 2,246,505 |
| Smith L. Mary | Chief Development Officer | 10/13/2021 | 23,000 |
| Smith L. Mary | Chief Development Officer | 10/13/2021 | 559,675 |
| Pichl Daniel | Chief People Officer | 09/08/2021 | 99,992 |
| Bain Capital Life Sciences Investors, LLC | 10% Owner | 08/10/2021 | 70,250,000 |
| Islam Saqib | Chief Executive Officer | 07/20/2021 | 1,442,751 |
| Islam Saqib | Chief Executive Officer | 07/19/2021 | 3,342,437 |
| Smith L. Mary | Chief Development Officer | 07/13/2021 | 23,000 |
| Smith L. Mary | Chief Development Officer | 07/13/2021 | 808,777 |
| ORBIMED ADVISORS LLC | 10% Owner | 07/01/2021 | 1,356,675 |
| Edris Badreddin | Chief Operating Officer | 07/01/2021 | 2,731,088 |
| ORBIMED ADVISORS LLC | 10% Owner | 06/28/2021 | 553,775 |
| ORBIMED ADVISORS LLC | 10% Owner | 06/25/2021 | 1,901,517 |
| ORBIMED ADVISORS LLC | 10% Owner | 06/24/2021 | 2,914,524 |
| ORBIMED ADVISORS LLC | 10% Owner | 06/23/2021 | 8,500 |
| SQUINTO STEPHEN P | Director | 04/28/2021 | 1,465,437 |
| SQUINTO STEPHEN P | Director | 04/27/2021 | 15,085 |
| Islam Saqib | Chief Executive Officer | 04/20/2021 | 1,598,279 |
| Islam Saqib | Chief Executive Officer | 04/19/2021 | 2,652,827 |
| SQUINTO STEPHEN P | Director | 04/15/2021 | 79,291 |
| SQUINTO STEPHEN P | Director | 04/14/2021 | 38,365 |
| Smith L. Mary | Chief Development Officer | 04/13/2021 | 23,000 |
| Smith L. Mary | Chief Development Officer | 04/13/2021 | 680,723 |
| Bain Capital Life Sciences Investors, LLC | 10% Owner | 03/09/2021 | 103,675,000 |
| ORBIMED ADVISORS LLC | 10% Owner | 03/01/2021 | 101,491,803 |
| Edris Badreddin | Chief Operating Officer | 01/25/2021 | 2,690,281 |
| Smith L. Mary | Chief Development Officer | 01/20/2021 | 22,267 |
| Smith L. Mary | Chief Development Officer | 01/20/2021 | 787,016 |
| Islam Saqib | Chief Executive Officer | 01/20/2021 | 173,180 |
| Islam Saqib | Chief Executive Officer | 01/19/2021 | 4,736,209 |
| Lewis-Hall Freda C | Director | 09/17/2019 | 900,000 |
| ORBIMED ADVISORS LLC | 10% Owner | 09/17/2019 | 4,950,000 |
| SQUINTO STEPHEN P | Director | 09/17/2019 | 4,950,000 |
| Bain Capital Life Sciences Investors, LLC | 10% Owner | 09/17/2019 | 2,700,000 |
| PFIZER INC | 10% Owner | 09/17/2019 | 900,000 |
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CHANGE IN SHARES OUTSTANDING FOR
STOCK BUYBACKS FOR
Period of Report
Previous Period
% Change in Shares
10-K/10-Q Filings
Quarter
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Period of Report: 12/31/2023
10-K/10-Q Filings: View
Previous Period
% Change in Shares
Quarter
09/30/2023
4.50%
1Q
06/30/2023
4.60%
2Q
03/31/2023
4.83%
3Q
12/31/2022
4.93%
4Q
09/30/2022
23.51%
5Q
06/30/2022
33.14%
6Q
03/31/2022
33.51%
7Q
12/31/2021
34.05%
8Q
09/30/2021
34.45%
9Q
06/30/2021
34.93%
10Q
03/31/2021
35.47%
11Q
12/31/2020
38.09%
12Q
09/30/2020
55.01%
13Q
06/30/2020
55.77%
14Q
03/31/2020
56.35%
15Q
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BUYBACK ANNOUNCEMENT(S) FOR
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