. (VPHM)
$49.96 - (-)
Market Cap: -
As of 09/16/16 12:00 AM EDT. Market closed.
. (VPHM)
$49.96
- (-)
Market Cap: -
As of 09/16/16 12:00 AM EDT. Market closed.
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52 week range
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INSIDER TRANSACTIONS FOR
| Owner | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| PIEN HOWARD H | Director | Jan 24, 2014 | Option Exercise | $50.00 | 9,000 | 450,000 | 0 | Jan 28, 2014, 09:23 PM |
| CLAYPOOL WILLIAM D MD | Director | Jan 24, 2014 | Option Exercise | $50.00 | 49,000 | 2,450,000 | 0 | Jan 28, 2014, 09:16 PM |
| McHugh Julie | Director | Jan 24, 2014 | Option Exercise | $50.00 | 8,666 | 433,300 | 0 | Jan 28, 2014, 09:13 PM |
| Leone John R | Director | Jan 24, 2014 | Option Exercise | $50.00 | 11,000 | 550,000 | 0 | Jan 28, 2014, 09:11 PM |
| GLASER ROBERT | Director | Jan 24, 2014 | Option Exercise | $50.00 | 45,860 | 2,293,000 | 0 | Jan 28, 2014, 09:09 PM |
| DOUGHERTY MICHAEL R | Director | Jan 24, 2014 | Option Exercise | $50.00 | 20,812 | 1,040,600 | 0 | Jan 28, 2014, 09:05 PM |
| BROOKE PAUL A | Director | Jan 24, 2014 | Option Exercise | $50.00 | 128,314 | 6,415,700 | 0 | Jan 28, 2014, 09:02 PM |
| Wolf John Peter III | VP, General Counsel | Jan 24, 2014 | Option Exercise | $50.00 | 110,768 | 5,538,400 | 0 | Jan 28, 2014, 08:58 PM |
| SOLAND DANIEL B | VP, Chief Operating Officer | Jan 24, 2014 | Option Exercise | $50.00 | 153,332 | 7,666,600 | 0 | Jan 28, 2014, 08:37 PM |
| Rowland Charles A Jr | VP, Chief Financial Officer | Jan 24, 2014 | Option Exercise | $50.00 | 87,026 | 4,351,300 | 0 | Jan 28, 2014, 08:35 PM |
| Pietrusko Robert | VP, Regulatory & Quality | Jan 24, 2014 | Option Exercise | $50.00 | 70,877 | 3,543,850 | 0 | Jan 28, 2014, 08:32 PM |
| MILANO VINCENT | President and CEO | Jan 24, 2014 | Option Exercise | $50.00 | 482,281 | 24,114,050 | 0 | Jan 28, 2014, 08:29 PM |
| Kirby John J. | V.P., Chief Accounting Officer | Jan 24, 2014 | Option Exercise | $50.00 | 60 | 3,000 | 0 | Jan 28, 2014, 08:26 PM |
| Fletcher Robert C. | V.P., Business Development | Jan 24, 2014 | Option Exercise | $50.00 | 37,227 | 1,861,350 | 0 | Jan 28, 2014, 08:22 PM |
| DOYLE THOMAS F | VP Strategic Initiatives | Jan 24, 2014 | Option Exercise | $50.00 | 112,089 | 5,604,450 | 0 | Jan 28, 2014, 08:18 PM |
| Broom Colin MD | VP & Chief Scientific Officer | Jan 24, 2014 | Option Exercise | $50.00 | 154,058 | 7,702,900 | 0 | Jan 28, 2014, 08:14 PM |
| DOYLE THOMAS F | VP Strategic Initiatives | Jan 21, 2014 | Option Exercise | $10.53 | 59,645 | 627,870 | 112,089 | Jan 22, 2014, 05:04 PM |
| Wolf John Peter III | VP, General Counsel | Jan 17, 2014 | Option Exercise | $11.39 | 69,785 | 794,817 | 110,768 | Jan 21, 2014, 11:44 AM |
| MILANO VINCENT | President and CEO | Jan 17, 2014 | Option Exercise | $8.67 | 79,126 | 686,213 | 482,281 | Jan 21, 2014, 11:41 AM |
| SOLAND DANIEL B | VP, Chief Operating Officer | Jan 08, 2014 | Option Exercise | $49.80 | 4,307 | 214,489 | 153,332 | Jan 10, 2014, 01:35 PM |
| SOLAND DANIEL B | VP, Chief Operating Officer | Jan 08, 2014 | Option Exercise | $9.45 | 19,289 | 182,222 | 153,890 | Jan 10, 2014, 01:35 PM |
| Rowland Charles A Jr | VP, Chief Financial Officer | Jan 08, 2014 | Option Exercise | $49.80 | 6,449 | 321,160 | 87,026 | Jan 10, 2014, 01:34 PM |
| Rowland Charles A Jr | VP, Chief Financial Officer | Jan 08, 2014 | Option Exercise | $9.50 | 28,753 | 273,157 | 88,003 | Jan 10, 2014, 01:34 PM |
| Pietrusko Robert | VP, Regulatory & Quality | Jan 08, 2014 | Option Exercise | $49.80 | 11,488 | 572,102 | 70,877 | Jan 10, 2014, 01:33 PM |
| Pietrusko Robert | VP, Regulatory & Quality | Jan 08, 2014 | Option Exercise | $10.87 | 45,837 | 498,154 | 74,194 | Jan 10, 2014, 01:33 PM |
| Broom Colin MD | VP & Chief Scientific Officer | Jan 08, 2014 | Option Exercise | $49.80 | 20,140 | 1,002,972 | 154,058 | Jan 10, 2014, 01:31 PM |
| Broom Colin MD | VP & Chief Scientific Officer | Jan 08, 2014 | Option Exercise | $5.21 | 142,142 | 740,574 | 156,192 | Jan 10, 2014, 01:31 PM |
| BROOKE PAUL A | Director | Jan 07, 2014 | Option Exercise | $49.89 | 686 | 34,225 | 128,314 | Jan 08, 2014, 11:08 AM |
| BROOKE PAUL A | Director | Jan 07, 2014 | Option Exercise | $3.42 | 10,000 | 34,200 | 129,000 | Jan 08, 2014, 11:08 AM |
| MILANO VINCENT | President and CEO | Jan 06, 2014 | Option Exercise | $3.55 | 40,309 | 143,097 | 403,155 | Jan 07, 2014, 04:08 PM |
| Pietrusko Robert | VP, Regulatory & Quality | Dec 27, 2013 | Option Exercise | $49.86 | 725 | 36,149 | 36,528 | Dec 31, 2013, 04:35 PM |
| Pietrusko Robert | VP, Regulatory & Quality | Dec 27, 2013 | Option Exercise | $5.91 | 4,675 | 27,629 | 37,253 | Dec 31, 2013, 04:35 PM |
| Rowland Charles A Jr | VP, Chief Financial Officer | Dec 27, 2013 | Option Exercise | $49.86 | 704 | 35,101 | 64,722 | Dec 31, 2013, 04:33 PM |
| Rowland Charles A Jr | VP, Chief Financial Officer | Dec 27, 2013 | Option Exercise | $5.91 | 4,540 | 26,831 | 65,426 | Dec 31, 2013, 04:33 PM |
| SOLAND DANIEL B | VP, Chief Operating Officer | Dec 27, 2013 | Option Exercise | $49.86 | 1,809 | 90,197 | 138,350 | Dec 31, 2013, 04:32 PM |
| SOLAND DANIEL B | VP, Chief Operating Officer | Dec 27, 2013 | Option Exercise | $5.91 | 11,500 | 67,965 | 140,159 | Dec 31, 2013, 04:32 PM |
| Pietrusko Robert | VP, Regulatory & Quality | Dec 18, 2013 | Option Exercise | $49.74 | 25,188 | 1,252,851 | 32,578 | Dec 20, 2013, 04:14 PM |
| Pietrusko Robert | VP, Regulatory & Quality | Dec 18, 2013 | Option Exercise | $8.42 | 49,911 | 420,087 | 49,989 | Dec 20, 2013, 04:14 PM |
| Rowland Charles A Jr | VP, Chief Financial Officer | Dec 18, 2013 | Option Exercise | $49.74 | 25,129 | 1,249,917 | 60,886 | Dec 20, 2013, 04:13 PM |
| Rowland Charles A Jr | VP, Chief Financial Officer | Dec 18, 2013 | Option Exercise | $9.26 | 49,006 | 453,673 | 72,721 | Dec 20, 2013, 04:13 PM |
| DOUGHERTY MICHAEL R | Director | Dec 18, 2013 | Option Exercise | $49.74 | 688 | 34,221 | 20,812 | Dec 20, 2013, 04:12 PM |
| DOUGHERTY MICHAEL R | Director | Dec 18, 2013 | Option Exercise | $3.42 | 10,000 | 34,200 | 21,500 | Dec 20, 2013, 04:12 PM |
| SOLAND DANIEL B | VP, Chief Operating Officer | Dec 18, 2013 | Option Exercise | $49.74 | 64,083 | 3,187,489 | 128,659 | Dec 20, 2013, 04:11 PM |
| SOLAND DANIEL B | VP, Chief Operating Officer | Dec 18, 2013 | Option Exercise | $7.94 | 120,784 | 959,521 | 175,213 | Dec 20, 2013, 04:11 PM |
| MILANO VINCENT | President and CEO | Dec 18, 2013 | Option Exercise | $49.74 | 337,810 | 16,802,670 | 362,846 | Dec 20, 2013, 04:08 PM |
| MILANO VINCENT | President and CEO | Dec 18, 2013 | Option Exercise | $10.78 | 586,310 | 6,317,885 | 416,541 | Dec 20, 2013, 04:08 PM |
| Wolf John Peter III | VP, General Counsel | Dec 18, 2013 | Option Exercise | $49.74 | 59,696 | 2,969,279 | 40,983 | Dec 20, 2013, 04:07 PM |
| Wolf John Peter III | VP, General Counsel | Dec 18, 2013 | Option Exercise | $14.65 | 100,227 | 1,468,392 | 48,403 | Dec 20, 2013, 04:07 PM |
| Fletcher Robert C. | V.P., Business Development | Dec 18, 2013 | Option Exercise | $49.74 | 51,974 | 2,585,187 | 37,227 | Dec 20, 2013, 04:06 PM |
| Fletcher Robert C. | V.P., Business Development | Dec 18, 2013 | Option Exercise | $13.79 | 88,972 | 1,226,530 | 46,425 | Dec 20, 2013, 04:06 PM |
| BROOKE PAUL A | Director | Feb 06, 2013 | Option Exercise | $1.77 | 10,000 | 17,700 | 114,500 | Feb 08, 2013, 04:21 PM |
| BROOKE PAUL A | Director | Feb 20, 2013 | Option Exercise | $1.77 | 10,000 | 17,700 | 114,500 | Feb 08, 2013, 04:05 PM |
| Broom Colin MD | VP & Chief Scientific Officer | Dec 24, 2012 | Sale | $22.53 | 17,500 | 394,301 | 20,167 | Dec 28, 2012, 04:03 PM |
| Broom Colin MD | VP & Chief Scientific Officer | Dec 27, 2012 | Option Exercise | $1.84 | 10,000 | 18,400 | 30,167 | Dec 28, 2012, 04:00 PM |
| Broom Colin MD | VP & Chief Scientific Officer | Dec 24, 2012 | Option Exercise | $1.84 | 17,500 | 32,200 | 55,167 | Dec 27, 2012, 04:17 PM |
| Broom Colin MD | VP & Chief Scientific Officer | Dec 24, 2012 | Sale | $22.53 | 17,500 | 394,301 | 37,667 | Dec 27, 2012, 04:17 PM |
| BROOKE PAUL A | Director | Dec 13, 2012 | Sale | $23.87 | 60,000 | 1,431,954 | 104,500 | Dec 17, 2012, 04:06 PM |
| Broom Colin MD | VP & Chief Scientific Officer | Dec 10, 2012 | Option Exercise | $8.69 | 74,999 | 651,490 | 87,667 | Dec 12, 2012, 04:12 PM |
| Broom Colin MD | VP & Chief Scientific Officer | Dec 10, 2012 | Sale | $24.07 | 74,999 | 1,805,016 | 37,667 | Dec 12, 2012, 04:12 PM |
| Wolf John Peter III | VP, General Counsel | Dec 03, 2012 | Option Exercise | $3.14 | 18,000 | 56,520 | 18,000 | Dec 05, 2012, 04:10 PM |
| Wolf John Peter III | VP, General Counsel | Dec 03, 2012 | Sale | $24.85 | 18,000 | 447,257 | 0 | Dec 05, 2012, 04:10 PM |
| DOUGHERTY MICHAEL R | Director | Dec 03, 2012 | Buy | $25.07 | 2,500 | 62,675 | 7,000 | Dec 05, 2012, 04:08 PM |
| CLAYPOOL WILLIAM D MD | Director | Dec 03, 2012 | Sale | $24.80 | 10,000 | 248,000 | 44,500 | Dec 05, 2012, 04:04 PM |
| GLASER ROBERT | Director | Nov 30, 2012 | Option Exercise | $8.72 | 30,000 | 261,500 | 61,360 | Dec 04, 2012, 04:08 PM |
| GLASER ROBERT | Director | Nov 30, 2012 | Sale | $24.78 | 30,000 | 743,385 | 41,360 | Dec 04, 2012, 04:08 PM |
| CLAYPOOL WILLIAM D MD | Director | Nov 28, 2012 | Option Exercise | $10.03 | 17,500 | 175,600 | 69,500 | Nov 30, 2012, 04:22 PM |
| CLAYPOOL WILLIAM D MD | Director | Nov 28, 2012 | Sale | $24.22 | 17,500 | 423,880 | 54,500 | Nov 30, 2012, 04:22 PM |
| MILANO VINCENT | President and CEO | Nov 28, 2012 | Option Exercise | $3.55 | 18,000 | 63,900 | 112,416 | Nov 30, 2012, 04:17 PM |
| CLAYPOOL WILLIAM D MD | Director | Nov 13, 2012 | Option Exercise | $7.22 | 22,500 | 162,500 | 67,000 | Nov 15, 2012, 04:30 PM |
| CLAYPOOL WILLIAM D MD | Director | Nov 13, 2012 | Sale | $24.93 | 22,500 | 561,011 | 54,500 | Nov 15, 2012, 04:30 PM |
| MILANO VINCENT | President and CEO | Nov 08, 2012 | Option Exercise | $4.53 | 83,418 | 378,273 | 136,416 | Nov 13, 2012, 04:06 PM |
| MILANO VINCENT | President and CEO | Nov 08, 2012 | Sale | $24.54 | 83,418 | 2,047,328 | 94,416 | Nov 13, 2012, 04:06 PM |
| CLAYPOOL WILLIAM D MD | Director | Nov 02, 2012 | Sale | $25.37 | 10,000 | 253,703 | 54,500 | Nov 05, 2012, 04:37 PM |
| CLAYPOOL WILLIAM D MD | Director | Jun 11, 2012 | Option Exercise | $3.42 | 10,000 | 34,200 | 74,500 | Jun 13, 2012, 04:03 PM |
| CLAYPOOL WILLIAM D MD | Director | Jun 11, 2012 | Sale | $20.04 | 10,000 | 200,430 | 64,500 | Jun 13, 2012, 04:03 PM |
| Pietrusko Robert | VP, Regulatory & Quality | Mar 23, 2012 | Option Exercise | $8.86 | 20,000 | 177,200 | 24,122 | Mar 27, 2012, 04:23 PM |
| Pietrusko Robert | VP, Regulatory & Quality | Mar 23, 2012 | Sale | $30.00 | 20,000 | 600,000 | 4,122 | Mar 27, 2012, 04:23 PM |
| SOLAND DANIEL B | VP, Chief Operating Officer | Mar 09, 2012 | Option Exercise | $29.65 | 21,071 | 624,755 | 70,103 | Mar 13, 2012, 04:31 PM |
| SOLAND DANIEL B | VP, Chief Operating Officer | Mar 09, 2012 | Option Exercise | $12.94 | 48,293 | 624,780 | 91,174 | Mar 13, 2012, 04:31 PM |
| Fletcher Robert C. | V.P., Business Development | Mar 09, 2012 | Option Exercise | $3.35 | 32,000 | 107,060 | 32,229 | Mar 12, 2012, 05:13 PM |
| Fletcher Robert C. | V.P., Business Development | Mar 09, 2012 | Sale | $29.65 | 32,000 | 948,954 | 229 | Mar 12, 2012, 05:13 PM |
| Morris Richard Steven | Chief Accounting Officer | Mar 09, 2012 | Option Exercise | $7.05 | 1,300 | 9,165 | 2,544 | Mar 12, 2012, 05:10 PM |
| Morris Richard Steven | Chief Accounting Officer | Mar 09, 2012 | Sale | $29.71 | 1,300 | 38,618 | 1,244 | Mar 12, 2012, 05:10 PM |
| Rowland Charles A Jr | VP, Chief Financial Officer | Mar 07, 2012 | Option Exercise | $29.49 | 12,715 | 374,965 | 35,048 | Mar 09, 2012, 04:08 PM |
| Rowland Charles A Jr | VP, Chief Financial Officer | Mar 07, 2012 | Option Exercise | $12.24 | 30,638 | 374,985 | 47,763 | Mar 09, 2012, 04:08 PM |
| Morris Richard Steven | Chief Accounting Officer | Mar 05, 2012 | Option Exercise | $6.62 | 5,300 | 35,085 | 6,544 | Mar 07, 2012, 08:38 AM |
| Morris Richard Steven | Chief Accounting Officer | Mar 05, 2012 | Sale | $33.01 | 5,300 | 174,953 | 1,244 | Mar 07, 2012, 08:38 AM |
| DOYLE THOMAS F | VP Strategic Initiatives | Mar 05, 2012 | Option Exercise | $3.26 | 210,000 | 684,700 | 262,444 | Mar 07, 2012, 08:36 AM |
| DOYLE THOMAS F | VP Strategic Initiatives | Mar 05, 2012 | Sale | $32.48 | 210,000 | 6,820,212 | 52,444 | Mar 07, 2012, 08:36 AM |
| SOLAND DANIEL B | VP, Chief Operating Officer | Mar 01, 2012 | Sale | $32.99 | 30,000 | 989,700 | 42,881 | Mar 06, 2012, 11:41 AM |
| Rowland Charles A Jr | VP, Chief Financial Officer | Mar 01, 2012 | Option Exercise | $9.99 | 70,000 | 699,200 | 99,875 | Mar 05, 2012, 04:01 PM |
| Rowland Charles A Jr | VP, Chief Financial Officer | Mar 01, 2012 | Sale | $32.12 | 82,750 | 2,657,631 | 29,875 | Mar 05, 2012, 04:01 PM |
| MILANO VINCENT | President and CEO | Jan 04, 2012 | Option Exercise | $27.91 | 7,224 | 201,622 | 94,384 | Jan 06, 2012, 04:10 PM |
| MILANO VINCENT | President and CEO | Jan 04, 2012 | Option Exercise | $27.91 | 10,000 | 279,100 | 101,608 | Jan 06, 2012, 04:10 PM |
| Fletcher Robert C. | V.P., Business Development | Dec 29, 2011 | Option Exercise | $27.93 | 1,071 | 29,913 | 229 | Jan 05, 2012, 04:03 PM |
| Fletcher Robert C. | V.P., Business Development | Dec 29, 2011 | Option Exercise | $22.99 | 1,300 | 29,887 | 1,300 | Jan 05, 2012, 04:03 PM |
| Fletcher Robert C. | V.P., Business Development | Dec 29, 2011 | Option Exercise | $27.93 | 1,131 | 31,589 | 169 | Jan 03, 2012, 04:01 PM |
| Fletcher Robert C. | V.P., Business Development | Dec 29, 2011 | Option Exercise | $22.99 | 1,300 | 29,887 | 1,300 | Jan 03, 2012, 04:01 PM |
| Broom Colin MD | VP & Chief Scientific Officer | Dec 23, 2011 | Option Exercise | $1.84 | 17,500 | 32,200 | 36,939 | Dec 27, 2011, 10:30 AM |
| 14159 capital (GP), LLC | 10% Owner | Dec 14, 2011 | Buy | $27.29 | 7,828 | 213,613 | 303,264 | Dec 16, 2011, 04:28 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | 10% Owner | Dec 14, 2011 | Buy | $27.29 | 291,706 | 7,960,161 | 9,840,469 | Dec 16, 2011, 04:27 PM |
| Baker Biotech Capital (GP), LLC | 10% Owner | Dec 14, 2011 | Buy | $27.29 | 50,566 | 1,379,860 | 1,966,090 | Dec 16, 2011, 04:27 PM |
| Broom Colin MD | VP & Chief Scientific Officer | Dec 14, 2011 | Option Exercise | $8.71 | 50,000 | 435,500 | 44,439 | Dec 15, 2011, 04:08 PM |
| Broom Colin MD | VP & Chief Scientific Officer | Dec 14, 2011 | Sale | $25.34 | 50,000 | 1,266,750 | 19,439 | Dec 15, 2011, 04:08 PM |
| Broom Colin MD | VP & Chief Scientific Officer | Dec 12, 2011 | Option Exercise | $7.05 | 17,670 | 124,574 | 37,109 | Dec 14, 2011, 04:10 PM |
| Broom Colin MD | VP & Chief Scientific Officer | Dec 13, 2011 | Option Exercise | $7.05 | 22,330 | 157,427 | 41,769 | Dec 14, 2011, 04:10 PM |
| Broom Colin MD | VP & Chief Scientific Officer | Dec 12, 2011 | Sale | $23.50 | 17,670 | 415,317 | 19,439 | Dec 14, 2011, 04:10 PM |
| Broom Colin MD | VP & Chief Scientific Officer | Dec 13, 2011 | Sale | $23.50 | 22,330 | 524,755 | 19,439 | Dec 14, 2011, 04:10 PM |
| MILANO VINCENT | President and CEO | Dec 05, 2011 | Option Exercise | $2.09 | 15,005 | 31,367 | 91,213 | Dec 06, 2011, 04:13 PM |
| DOYLE THOMAS F | VP Strategic Initiatives | Dec 01, 2011 | Option Exercise | $20.16 | 10,000 | 201,600 | 62,444 | Dec 05, 2011, 04:06 PM |
| DOYLE THOMAS F | VP Strategic Initiatives | Dec 01, 2011 | Sale | $23.82 | 10,000 | 238,159 | 52,444 | Dec 05, 2011, 04:06 PM |
| Pietrusko Robert | VP, Regulatory & Quality | Nov 30, 2011 | Option Exercise | $9.99 | 20,000 | 199,800 | 23,910 | Dec 01, 2011, 04:04 PM |
| Pietrusko Robert | VP, Regulatory & Quality | Nov 30, 2011 | Sale | $24.00 | 20,000 | 480,000 | 3,910 | Dec 01, 2011, 04:04 PM |
| GLASER ROBERT | Director | Nov 28, 2011 | Option Exercise | $3.00 | 5,000 | 15,000 | 41,860 | Nov 29, 2011, 04:33 PM |
| GLASER ROBERT | Director | Nov 28, 2011 | Sale | $23.00 | 5,000 | 115,000 | 36,860 | Nov 29, 2011, 04:33 PM |
| Pietrusko Robert | VP, Regulatory & Quality | Nov 28, 2011 | Option Exercise | $9.99 | 19,000 | 189,810 | 22,910 | Nov 29, 2011, 04:26 PM |
| Pietrusko Robert | VP, Regulatory & Quality | Nov 28, 2011 | Sale | $23.00 | 19,000 | 437,000 | 3,910 | Nov 29, 2011, 04:26 PM |
| Pietrusko Robert | VP, Regulatory & Quality | Nov 23, 2011 | Option Exercise | $9.99 | 1,000 | 9,990 | 3,910 | Nov 28, 2011, 04:53 PM |
| Pietrusko Robert | VP, Regulatory & Quality | Nov 23, 2011 | Sale | $23.00 | 1,000 | 23,000 | 2,910 | Nov 28, 2011, 04:53 PM |
| MILANO VINCENT | President and CEO | Nov 21, 2011 | Option Exercise | $3.36 | 76,687 | 257,937 | 117,899 | Nov 23, 2011, 04:03 PM |
| MILANO VINCENT | President and CEO | Nov 21, 2011 | Sale | $22.53 | 76,687 | 1,727,444 | 76,208 | Nov 23, 2011, 04:03 PM |
| Morris Richard Steven | Chief Accounting Officer | Nov 16, 2011 | Option Exercise | $20.28 | 2,000 | 40,560 | 3,165 | Nov 17, 2011, 04:05 PM |
| Morris Richard Steven | Chief Accounting Officer | Nov 16, 2011 | Sale | $22.59 | 2,000 | 45,181 | 1,165 | Nov 17, 2011, 04:05 PM |
| Pietrusko Robert | VP, Regulatory & Quality | Nov 14, 2011 | Option Exercise | $8.86 | 20,000 | 177,200 | 23,910 | Nov 15, 2011, 04:05 PM |
| Pietrusko Robert | VP, Regulatory & Quality | Nov 14, 2011 | Sale | $22.00 | 20,000 | 440,000 | 3,910 | Nov 15, 2011, 04:05 PM |
| Wolf John Peter III | VP, General Counsel | Nov 07, 2011 | Option Exercise | $2.44 | 12,250 | 29,890 | 12,250 | Nov 09, 2011, 04:13 PM |
| Wolf John Peter III | VP, General Counsel | Nov 07, 2011 | Sale | $21.08 | 12,250 | 258,194 | 0 | Nov 09, 2011, 04:13 PM |
| Broom Colin MD | VP & Chief Scientific Officer | Nov 07, 2011 | Option Exercise | $5.91 | 20,000 | 118,200 | 39,439 | Nov 08, 2011, 04:03 PM |
| Broom Colin MD | VP & Chief Scientific Officer | Nov 07, 2011 | Sale | $21.00 | 20,000 | 420,002 | 19,639 | Nov 08, 2011, 04:03 PM |
| Broom Colin MD | VP & Chief Scientific Officer | Nov 01, 2011 | Option Exercise | $3.14 | 24,121 | 75,740 | 43,560 | Nov 02, 2011, 04:13 PM |
| Broom Colin MD | VP & Chief Scientific Officer | Oct 31, 2011 | Option Exercise | $3.14 | 20,495 | 64,354 | 39,934 | Nov 02, 2011, 04:13 PM |
| Broom Colin MD | VP & Chief Scientific Officer | Nov 01, 2011 | Sale | $20.05 | 24,121 | 483,641 | 19,439 | Nov 02, 2011, 04:13 PM |
| Broom Colin MD | VP & Chief Scientific Officer | Oct 31, 2011 | Sale | $20.42 | 20,495 | 418,555 | 19,439 | Nov 02, 2011, 04:13 PM |
| Baker Biotech Capital (GP), LLC | 10% Owner | Oct 04, 2011 | Buy | $17.48 | 2,511 | 43,883 | 1,899,246 | Oct 06, 2011, 05:36 PM |
| Baker Biotech Capital (GP), LLC | 10% Owner | Oct 05, 2011 | Buy | $18.18 | 16,278 | 295,984 | 1,915,524 | Oct 06, 2011, 05:36 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | 10% Owner | Oct 05, 2011 | Buy | $18.18 | 145,763 | 2,650,423 | 9,548,763 | Oct 06, 2011, 05:35 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | 10% Owner | Oct 04, 2011 | Buy | $17.48 | 45,584 | 796,644 | 9,403,000 | Oct 06, 2011, 05:35 PM |
| 14159 capital (GP), LLC | 10% Owner | Oct 05, 2011 | Buy | $18.18 | 6,017 | 109,408 | 295,436 | Oct 06, 2011, 05:34 PM |
| 14159 capital (GP), LLC | 10% Owner | Oct 04, 2011 | Buy | $17.48 | 1,905 | 33,293 | 289,419 | Oct 06, 2011, 05:34 PM |
| 14159 capital (GP), LLC | 10% Owner | Sep 29, 2011 | Buy | $17.99 | 9,507 | 171,004 | 282,502 | Oct 03, 2011, 06:43 PM |
| 14159 capital (GP), LLC | 10% Owner | Sep 30, 2011 | Buy | $18.12 | 5,012 | 90,801 | 287,514 | Oct 03, 2011, 06:43 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | 10% Owner | Oct 03, 2011 | Buy | $17.70 | 516,203 | 9,134,858 | 9,357,416 | Oct 03, 2011, 06:42 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | 10% Owner | Sep 30, 2011 | Buy | $18.12 | 131,978 | 2,391,014 | 8,841,213 | Oct 03, 2011, 06:42 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | 10% Owner | Sep 29, 2011 | Buy | $17.99 | 249,915 | 4,495,274 | 8,709,235 | Oct 03, 2011, 06:42 PM |
| Baker Biotech Capital (GP), LLC | 10% Owner | Sep 30, 2011 | Buy | $18.12 | 20,210 | 366,140 | 1,896,735 | Oct 03, 2011, 06:42 PM |
| Baker Biotech Capital (GP), LLC | 10% Owner | Sep 29, 2011 | Buy | $17.99 | 32,995 | 593,488 | 1,876,525 | Oct 03, 2011, 06:42 PM |
| Baker Biotech Capital (GP), LLC | 10% Owner | Sep 23, 2011 | Buy | $17.74 | 36,728 | 651,492 | 1,816,749 | Sep 26, 2011, 05:46 PM |
| Baker Biotech Capital (GP), LLC | 10% Owner | Sep 22, 2011 | Buy | $17.43 | 9,340 | 162,759 | 1,780,021 | Sep 26, 2011, 05:46 PM |
| Baker Biotech Capital (GP), LLC | 10% Owner | Sep 26, 2011 | Buy | $18.13 | 26,781 | 485,450 | 1,843,530 | Sep 26, 2011, 05:46 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | 10% Owner | Sep 26, 2011 | Buy | $18.13 | 159,641 | 2,893,756 | 8,459,320 | Sep 26, 2011, 05:40 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | 10% Owner | Sep 23, 2011 | Buy | $17.74 | 224,769 | 3,987,016 | 8,299,679 | Sep 26, 2011, 05:40 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | 10% Owner | Sep 22, 2011 | Buy | $17.43 | 63,151 | 1,100,469 | 8,074,910 | Sep 26, 2011, 05:40 PM |
| 14159 capital (GP), LLC | 10% Owner | Sep 23, 2011 | Buy | $17.74 | 8,933 | 158,456 | 266,708 | Sep 26, 2011, 05:34 PM |
| 14159 capital (GP), LLC | 10% Owner | Sep 22, 2011 | Buy | $17.43 | 2,509 | 43,722 | 257,775 | Sep 26, 2011, 05:34 PM |
| 14159 capital (GP), LLC | 10% Owner | Sep 26, 2011 | Buy | $18.13 | 6,287 | 113,962 | 272,995 | Sep 26, 2011, 05:34 PM |
| Pietrusko Robert | VP, Regulatory & Quality | Aug 31, 2011 | Option Exercise | $20.00 | 20,000 | 400,000 | 23,910 | Sep 01, 2011, 04:23 PM |
| Pietrusko Robert | VP, Regulatory & Quality | Aug 31, 2011 | Sale | $20.00 | 20,000 | 400,000 | 3,910 | Sep 01, 2011, 04:23 PM |
| Baker Biotech Capital (GP), LLC | 10% Owner | Aug 23, 2011 | Buy | $16.97 | 5,468 | 92,814 | 1,770,681 | Aug 25, 2011, 05:19 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | 10% Owner | Aug 23, 2011 | Buy | $16.97 | 32,704 | 555,121 | 8,011,759 | Aug 25, 2011, 05:17 PM |
| 14159 capital (GP), LLC | 10% Owner | Aug 23, 2011 | Buy | $16.97 | 503 | 8,538 | 255,266 | Aug 25, 2011, 05:13 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | 10% Owner | Aug 10, 2011 | Buy | $16.58 | 244,049 | 4,047,028 | 7,979,055 | Aug 12, 2011, 04:08 PM |
| 14159 capital (GP), LLC | 10% Owner | Aug 10, 2011 | Buy | $16.58 | 5,934 | 98,403 | 254,763 | Aug 12, 2011, 04:07 PM |
| Rowland Charles A Jr | VP, Chief Financial Officer | Mar 14, 2011 | Option Exercise | $8.02 | 35,000 | 280,600 | 63,496 | Mar 15, 2011, 04:50 PM |
| Rowland Charles A Jr | VP, Chief Financial Officer | Mar 14, 2011 | Sale | $18.57 | 35,000 | 649,950 | 53,496 | Mar 15, 2011, 04:50 PM |
| CLAYPOOL WILLIAM D MD | Director | Mar 03, 2011 | Option Exercise | $2.98 | 38,641 | 115,105 | 85,000 | Mar 04, 2011, 04:25 PM |
| CLAYPOOL WILLIAM D MD | Director | Mar 03, 2011 | Sale | $18.27 | 38,641 | 706,065 | 81,100 | Mar 04, 2011, 04:25 PM |
| Broom Colin MD | VP & Chief Scientific Officer | Dec 31, 2010 | Option Exercise | $1.84 | 2,500 | 4,600 | 17,440 | Jan 04, 2011, 05:12 PM |
| MILANO VINCENT | President and CEO | Dec 13, 2010 | Option Exercise | $16.89 | 6,272 | 105,934 | 64,390 | Dec 15, 2010, 04:56 PM |
| MILANO VINCENT | President and CEO | Dec 13, 2010 | Option Exercise | $14.13 | 10,000 | 141,250 | 74,390 | Dec 15, 2010, 04:56 PM |
| DOYLE THOMAS F | VP Strategic Initiatives | Dec 13, 2010 | Option Exercise | $16.89 | 8,363 | 141,251 | 58,716 | Dec 15, 2010, 04:54 PM |
| DOYLE THOMAS F | VP Strategic Initiatives | Dec 13, 2010 | Option Exercise | $14.13 | 10,000 | 141,250 | 60,807 | Dec 15, 2010, 04:54 PM |
| GLASER ROBERT | Director | Dec 14, 2010 | Sale | $16.75 | 5,000 | 83,750 | 36,860 | Dec 15, 2010, 04:52 PM |
| Morris Richard Steven | Chief Accounting Officer | Dec 08, 2010 | Option Exercise | $3.55 | 1,200 | 4,260 | 1,769 | Dec 10, 2010, 04:20 PM |
| Morris Richard Steven | Chief Accounting Officer | Dec 09, 2010 | Option Exercise | $3.24 | 13,300 | 43,115 | 13,869 | Dec 10, 2010, 04:20 PM |
| Morris Richard Steven | Chief Accounting Officer | Dec 09, 2010 | Sale | $16.56 | 13,300 | 220,248 | 3,869 | Dec 10, 2010, 04:20 PM |
| Morris Richard Steven | Chief Accounting Officer | Dec 08, 2010 | Sale | $16.55 | 1,200 | 19,860 | 569 | Dec 10, 2010, 04:20 PM |
| CLAYPOOL WILLIAM D MD | Director | Nov 09, 2010 | Option Exercise | $2.94 | 6,359 | 18,695 | 66,359 | Nov 12, 2010, 09:03 AM |
| CLAYPOOL WILLIAM D MD | Director | Nov 09, 2010 | Sale | $17.03 | 6,359 | 108,290 | 64,159 | Nov 12, 2010, 09:03 AM |
| Broom Colin MD | VP & Chief Scientific Officer | Sep 09, 2010 | Option Exercise | $1.84 | 17,040 | 31,354 | 32,153 | Sep 13, 2010, 05:47 PM |
| Broom Colin MD | VP & Chief Scientific Officer | Sep 13, 2010 | Option Exercise | $1.84 | 5,060 | 9,310 | 20,173 | Sep 13, 2010, 05:47 PM |
| Broom Colin MD | VP & Chief Scientific Officer | Sep 10, 2010 | Option Exercise | $1.84 | 7,900 | 14,536 | 23,013 | Sep 13, 2010, 05:47 PM |
| Broom Colin MD | VP & Chief Scientific Officer | Sep 09, 2010 | Sale | $13.26 | 17,040 | 225,867 | 32,053 | Sep 13, 2010, 05:47 PM |
| Broom Colin MD | VP & Chief Scientific Officer | Sep 13, 2010 | Sale | $13.28 | 5,060 | 67,207 | 19,873 | Sep 13, 2010, 05:47 PM |
| Broom Colin MD | VP & Chief Scientific Officer | Sep 10, 2010 | Sale | $13.25 | 7,900 | 104,692 | 22,913 | Sep 13, 2010, 05:47 PM |
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Buy
Sale
Option Exercise
| Owner | Relationship | Date | Value($) |
| PIEN HOWARD H | Director | 01/24/2014 | 450,000 |
| CLAYPOOL WILLIAM D MD | Director | 01/24/2014 | 2,450,000 |
| McHugh Julie | Director | 01/24/2014 | 433,300 |
| Leone John R | Director | 01/24/2014 | 550,000 |
| GLASER ROBERT | Director | 01/24/2014 | 2,293,000 |
| DOUGHERTY MICHAEL R | Director | 01/24/2014 | 1,040,600 |
| BROOKE PAUL A | Director | 01/24/2014 | 6,415,700 |
| Wolf John Peter III | VP, General Counsel | 01/24/2014 | 5,538,400 |
| SOLAND DANIEL B | VP, Chief Operating Officer | 01/24/2014 | 7,666,600 |
| Rowland Charles A Jr | VP, Chief Financial Officer | 01/24/2014 | 4,351,300 |
| Pietrusko Robert | VP, Regulatory & Quality | 01/24/2014 | 3,543,850 |
| MILANO VINCENT | President and CEO | 01/24/2014 | 24,114,050 |
| Kirby John J. | V.P., Chief Accounting Officer | 01/24/2014 | 3,000 |
| Fletcher Robert C. | V.P., Business Development | 01/24/2014 | 1,861,350 |
| DOYLE THOMAS F | VP Strategic Initiatives | 01/24/2014 | 5,604,450 |
| Broom Colin MD | VP & Chief Scientific Officer | 01/24/2014 | 7,702,900 |
| DOYLE THOMAS F | VP Strategic Initiatives | 01/21/2014 | 627,870 |
| Wolf John Peter III | VP, General Counsel | 01/17/2014 | 794,817 |
| MILANO VINCENT | President and CEO | 01/17/2014 | 686,213 |
| SOLAND DANIEL B | VP, Chief Operating Officer | 01/08/2014 | 214,489 |
| SOLAND DANIEL B | VP, Chief Operating Officer | 01/08/2014 | 182,222 |
| Rowland Charles A Jr | VP, Chief Financial Officer | 01/08/2014 | 321,160 |
| Rowland Charles A Jr | VP, Chief Financial Officer | 01/08/2014 | 273,157 |
| Pietrusko Robert | VP, Regulatory & Quality | 01/08/2014 | 572,102 |
| Pietrusko Robert | VP, Regulatory & Quality | 01/08/2014 | 498,154 |
| Broom Colin MD | VP & Chief Scientific Officer | 01/08/2014 | 1,002,972 |
| Broom Colin MD | VP & Chief Scientific Officer | 01/08/2014 | 740,574 |
| BROOKE PAUL A | Director | 01/07/2014 | 34,225 |
| BROOKE PAUL A | Director | 01/07/2014 | 34,200 |
| MILANO VINCENT | President and CEO | 01/06/2014 | 143,097 |
| Pietrusko Robert | VP, Regulatory & Quality | 12/27/2013 | 36,149 |
| Pietrusko Robert | VP, Regulatory & Quality | 12/27/2013 | 27,629 |
| Rowland Charles A Jr | VP, Chief Financial Officer | 12/27/2013 | 35,101 |
| Rowland Charles A Jr | VP, Chief Financial Officer | 12/27/2013 | 26,831 |
| SOLAND DANIEL B | VP, Chief Operating Officer | 12/27/2013 | 90,197 |
| SOLAND DANIEL B | VP, Chief Operating Officer | 12/27/2013 | 67,965 |
| Pietrusko Robert | VP, Regulatory & Quality | 12/18/2013 | 1,252,851 |
| Pietrusko Robert | VP, Regulatory & Quality | 12/18/2013 | 420,087 |
| Rowland Charles A Jr | VP, Chief Financial Officer | 12/18/2013 | 1,249,917 |
| Rowland Charles A Jr | VP, Chief Financial Officer | 12/18/2013 | 453,673 |
| DOUGHERTY MICHAEL R | Director | 12/18/2013 | 34,221 |
| DOUGHERTY MICHAEL R | Director | 12/18/2013 | 34,200 |
| SOLAND DANIEL B | VP, Chief Operating Officer | 12/18/2013 | 3,187,489 |
| SOLAND DANIEL B | VP, Chief Operating Officer | 12/18/2013 | 959,521 |
| MILANO VINCENT | President and CEO | 12/18/2013 | 16,802,670 |
| MILANO VINCENT | President and CEO | 12/18/2013 | 6,317,885 |
| Wolf John Peter III | VP, General Counsel | 12/18/2013 | 2,969,279 |
| Wolf John Peter III | VP, General Counsel | 12/18/2013 | 1,468,392 |
| Fletcher Robert C. | V.P., Business Development | 12/18/2013 | 2,585,187 |
| Fletcher Robert C. | V.P., Business Development | 12/18/2013 | 1,226,530 |
| BROOKE PAUL A | Director | 02/06/2013 | 17,700 |
| BROOKE PAUL A | Director | 02/20/2013 | 17,700 |
| Broom Colin MD | VP & Chief Scientific Officer | 12/24/2012 | 394,301 |
| Broom Colin MD | VP & Chief Scientific Officer | 12/27/2012 | 18,400 |
| Broom Colin MD | VP & Chief Scientific Officer | 12/24/2012 | 32,200 |
| Broom Colin MD | VP & Chief Scientific Officer | 12/24/2012 | 394,301 |
| BROOKE PAUL A | Director | 12/13/2012 | 1,431,954 |
| Broom Colin MD | VP & Chief Scientific Officer | 12/10/2012 | 651,490 |
| Broom Colin MD | VP & Chief Scientific Officer | 12/10/2012 | 1,805,016 |
| Wolf John Peter III | VP, General Counsel | 12/03/2012 | 56,520 |
| Wolf John Peter III | VP, General Counsel | 12/03/2012 | 447,257 |
| DOUGHERTY MICHAEL R | Director | 12/03/2012 | 62,675 |
| CLAYPOOL WILLIAM D MD | Director | 12/03/2012 | 248,000 |
| GLASER ROBERT | Director | 11/30/2012 | 261,500 |
| GLASER ROBERT | Director | 11/30/2012 | 743,385 |
| CLAYPOOL WILLIAM D MD | Director | 11/28/2012 | 175,600 |
| CLAYPOOL WILLIAM D MD | Director | 11/28/2012 | 423,880 |
| MILANO VINCENT | President and CEO | 11/28/2012 | 63,900 |
| CLAYPOOL WILLIAM D MD | Director | 11/13/2012 | 162,500 |
| CLAYPOOL WILLIAM D MD | Director | 11/13/2012 | 561,011 |
| MILANO VINCENT | President and CEO | 11/08/2012 | 378,273 |
| MILANO VINCENT | President and CEO | 11/08/2012 | 2,047,328 |
| CLAYPOOL WILLIAM D MD | Director | 11/02/2012 | 253,703 |
| CLAYPOOL WILLIAM D MD | Director | 06/11/2012 | 34,200 |
| CLAYPOOL WILLIAM D MD | Director | 06/11/2012 | 200,430 |
| Pietrusko Robert | VP, Regulatory & Quality | 03/23/2012 | 177,200 |
| Pietrusko Robert | VP, Regulatory & Quality | 03/23/2012 | 600,000 |
| SOLAND DANIEL B | VP, Chief Operating Officer | 03/09/2012 | 624,755 |
| SOLAND DANIEL B | VP, Chief Operating Officer | 03/09/2012 | 624,780 |
| Fletcher Robert C. | V.P., Business Development | 03/09/2012 | 107,060 |
| Fletcher Robert C. | V.P., Business Development | 03/09/2012 | 948,954 |
| Morris Richard Steven | Chief Accounting Officer | 03/09/2012 | 9,165 |
| Morris Richard Steven | Chief Accounting Officer | 03/09/2012 | 38,618 |
| Rowland Charles A Jr | VP, Chief Financial Officer | 03/07/2012 | 374,965 |
| Rowland Charles A Jr | VP, Chief Financial Officer | 03/07/2012 | 374,985 |
| Morris Richard Steven | Chief Accounting Officer | 03/05/2012 | 35,085 |
| Morris Richard Steven | Chief Accounting Officer | 03/05/2012 | 174,953 |
| DOYLE THOMAS F | VP Strategic Initiatives | 03/05/2012 | 684,700 |
| DOYLE THOMAS F | VP Strategic Initiatives | 03/05/2012 | 6,820,212 |
| SOLAND DANIEL B | VP, Chief Operating Officer | 03/01/2012 | 989,700 |
| Rowland Charles A Jr | VP, Chief Financial Officer | 03/01/2012 | 699,200 |
| Rowland Charles A Jr | VP, Chief Financial Officer | 03/01/2012 | 2,657,631 |
| MILANO VINCENT | President and CEO | 01/04/2012 | 201,622 |
| MILANO VINCENT | President and CEO | 01/04/2012 | 279,100 |
| Fletcher Robert C. | V.P., Business Development | 12/29/2011 | 29,913 |
| Fletcher Robert C. | V.P., Business Development | 12/29/2011 | 29,887 |
| Fletcher Robert C. | V.P., Business Development | 12/29/2011 | 31,589 |
| Fletcher Robert C. | V.P., Business Development | 12/29/2011 | 29,887 |
| Broom Colin MD | VP & Chief Scientific Officer | 12/23/2011 | 32,200 |
| 14159 capital (GP), LLC | 10% Owner | 12/14/2011 | 213,613 |
| Baker Brothers Life Sciences Capital (GP), LLC | 10% Owner | 12/14/2011 | 7,960,161 |
| Baker Biotech Capital (GP), LLC | 10% Owner | 12/14/2011 | 1,379,860 |
| Broom Colin MD | VP & Chief Scientific Officer | 12/14/2011 | 435,500 |
| Broom Colin MD | VP & Chief Scientific Officer | 12/14/2011 | 1,266,750 |
| Broom Colin MD | VP & Chief Scientific Officer | 12/12/2011 | 124,574 |
| Broom Colin MD | VP & Chief Scientific Officer | 12/13/2011 | 157,427 |
| Broom Colin MD | VP & Chief Scientific Officer | 12/12/2011 | 415,317 |
| Broom Colin MD | VP & Chief Scientific Officer | 12/13/2011 | 524,755 |
| MILANO VINCENT | President and CEO | 12/05/2011 | 31,367 |
| DOYLE THOMAS F | VP Strategic Initiatives | 12/01/2011 | 201,600 |
| DOYLE THOMAS F | VP Strategic Initiatives | 12/01/2011 | 238,159 |
| Pietrusko Robert | VP, Regulatory & Quality | 11/30/2011 | 199,800 |
| Pietrusko Robert | VP, Regulatory & Quality | 11/30/2011 | 480,000 |
| GLASER ROBERT | Director | 11/28/2011 | 15,000 |
| GLASER ROBERT | Director | 11/28/2011 | 115,000 |
| Pietrusko Robert | VP, Regulatory & Quality | 11/28/2011 | 189,810 |
| Pietrusko Robert | VP, Regulatory & Quality | 11/28/2011 | 437,000 |
| Pietrusko Robert | VP, Regulatory & Quality | 11/23/2011 | 9,990 |
| Pietrusko Robert | VP, Regulatory & Quality | 11/23/2011 | 23,000 |
| MILANO VINCENT | President and CEO | 11/21/2011 | 257,937 |
| MILANO VINCENT | President and CEO | 11/21/2011 | 1,727,444 |
| Morris Richard Steven | Chief Accounting Officer | 11/16/2011 | 40,560 |
| Morris Richard Steven | Chief Accounting Officer | 11/16/2011 | 45,181 |
| Pietrusko Robert | VP, Regulatory & Quality | 11/14/2011 | 177,200 |
| Pietrusko Robert | VP, Regulatory & Quality | 11/14/2011 | 440,000 |
| Wolf John Peter III | VP, General Counsel | 11/07/2011 | 29,890 |
| Wolf John Peter III | VP, General Counsel | 11/07/2011 | 258,194 |
| Broom Colin MD | VP & Chief Scientific Officer | 11/07/2011 | 118,200 |
| Broom Colin MD | VP & Chief Scientific Officer | 11/07/2011 | 420,002 |
| Broom Colin MD | VP & Chief Scientific Officer | 11/01/2011 | 75,740 |
| Broom Colin MD | VP & Chief Scientific Officer | 10/31/2011 | 64,354 |
| Broom Colin MD | VP & Chief Scientific Officer | 11/01/2011 | 483,641 |
| Broom Colin MD | VP & Chief Scientific Officer | 10/31/2011 | 418,555 |
| Baker Biotech Capital (GP), LLC | 10% Owner | 10/04/2011 | 43,883 |
| Baker Biotech Capital (GP), LLC | 10% Owner | 10/05/2011 | 295,984 |
| Baker Brothers Life Sciences Capital (GP), LLC | 10% Owner | 10/05/2011 | 2,650,423 |
| Baker Brothers Life Sciences Capital (GP), LLC | 10% Owner | 10/04/2011 | 796,644 |
| 14159 capital (GP), LLC | 10% Owner | 10/05/2011 | 109,408 |
| 14159 capital (GP), LLC | 10% Owner | 10/04/2011 | 33,293 |
| 14159 capital (GP), LLC | 10% Owner | 09/29/2011 | 171,004 |
| 14159 capital (GP), LLC | 10% Owner | 09/30/2011 | 90,801 |
| Baker Brothers Life Sciences Capital (GP), LLC | 10% Owner | 10/03/2011 | 9,134,858 |
| Baker Brothers Life Sciences Capital (GP), LLC | 10% Owner | 09/30/2011 | 2,391,014 |
| Baker Brothers Life Sciences Capital (GP), LLC | 10% Owner | 09/29/2011 | 4,495,274 |
| Baker Biotech Capital (GP), LLC | 10% Owner | 09/30/2011 | 366,140 |
| Baker Biotech Capital (GP), LLC | 10% Owner | 09/29/2011 | 593,488 |
| Baker Biotech Capital (GP), LLC | 10% Owner | 09/23/2011 | 651,492 |
| Baker Biotech Capital (GP), LLC | 10% Owner | 09/22/2011 | 162,759 |
| Baker Biotech Capital (GP), LLC | 10% Owner | 09/26/2011 | 485,450 |
| Baker Brothers Life Sciences Capital (GP), LLC | 10% Owner | 09/26/2011 | 2,893,756 |
| Baker Brothers Life Sciences Capital (GP), LLC | 10% Owner | 09/23/2011 | 3,987,016 |
| Baker Brothers Life Sciences Capital (GP), LLC | 10% Owner | 09/22/2011 | 1,100,469 |
| 14159 capital (GP), LLC | 10% Owner | 09/23/2011 | 158,456 |
| 14159 capital (GP), LLC | 10% Owner | 09/22/2011 | 43,722 |
| 14159 capital (GP), LLC | 10% Owner | 09/26/2011 | 113,962 |
| Pietrusko Robert | VP, Regulatory & Quality | 08/31/2011 | 400,000 |
| Pietrusko Robert | VP, Regulatory & Quality | 08/31/2011 | 400,000 |
| Baker Biotech Capital (GP), LLC | 10% Owner | 08/23/2011 | 92,814 |
| Baker Brothers Life Sciences Capital (GP), LLC | 10% Owner | 08/23/2011 | 555,121 |
| 14159 capital (GP), LLC | 10% Owner | 08/23/2011 | 8,538 |
| Baker Brothers Life Sciences Capital (GP), LLC | 10% Owner | 08/10/2011 | 4,047,028 |
| 14159 capital (GP), LLC | 10% Owner | 08/10/2011 | 98,403 |
| Rowland Charles A Jr | VP, Chief Financial Officer | 03/14/2011 | 280,600 |
| Rowland Charles A Jr | VP, Chief Financial Officer | 03/14/2011 | 649,950 |
| CLAYPOOL WILLIAM D MD | Director | 03/03/2011 | 115,105 |
| CLAYPOOL WILLIAM D MD | Director | 03/03/2011 | 706,065 |
| Broom Colin MD | VP & Chief Scientific Officer | 12/31/2010 | 4,600 |
| MILANO VINCENT | President and CEO | 12/13/2010 | 105,934 |
| MILANO VINCENT | President and CEO | 12/13/2010 | 141,250 |
| DOYLE THOMAS F | VP Strategic Initiatives | 12/13/2010 | 141,251 |
| DOYLE THOMAS F | VP Strategic Initiatives | 12/13/2010 | 141,250 |
| GLASER ROBERT | Director | 12/14/2010 | 83,750 |
| Morris Richard Steven | Chief Accounting Officer | 12/08/2010 | 4,260 |
| Morris Richard Steven | Chief Accounting Officer | 12/09/2010 | 43,115 |
| Morris Richard Steven | Chief Accounting Officer | 12/09/2010 | 220,248 |
| Morris Richard Steven | Chief Accounting Officer | 12/08/2010 | 19,860 |
| CLAYPOOL WILLIAM D MD | Director | 11/09/2010 | 18,695 |
| CLAYPOOL WILLIAM D MD | Director | 11/09/2010 | 108,290 |
| Broom Colin MD | VP & Chief Scientific Officer | 09/09/2010 | 31,354 |
| Broom Colin MD | VP & Chief Scientific Officer | 09/13/2010 | 9,310 |
| Broom Colin MD | VP & Chief Scientific Officer | 09/10/2010 | 14,536 |
| Broom Colin MD | VP & Chief Scientific Officer | 09/09/2010 | 225,867 |
| Broom Colin MD | VP & Chief Scientific Officer | 09/13/2010 | 67,207 |
| Broom Colin MD | VP & Chief Scientific Officer | 09/10/2010 | 104,692 |
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