. (TZYM)
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As of 12/31/69 07:00 PM EST. Market closed.
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As of 12/31/69 07:00 PM EST. Market closed.
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INSIDER TRANSACTIONS FOR
| Owner | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| Grais Linda S | President and CEO | Dec 11, 2017 | Option Exercise | $1.52 | 300,000 | 456,000 | 0 | Dec 11, 2017, 03:25 PM |
| Kjellson Nina S | Director | Dec 11, 2017 | Option Exercise | $1.52 | 12,500 | 19,000 | 0 | Dec 11, 2017, 03:25 PM |
| Bukofzer Stan | Chief Medical Officer | Dec 11, 2017 | Option Exercise | $1.52 | 202,500 | 307,800 | 0 | Dec 11, 2017, 03:24 PM |
| James Steven P | Director | Dec 11, 2017 | Option Exercise | $1.52 | 12,500 | 19,000 | 0 | Dec 11, 2017, 03:24 PM |
| Byrnes Michael | CFO and Treasurer | Dec 11, 2017 | Option Exercise | $1.52 | 163,000 | 247,760 | 0 | Dec 11, 2017, 03:23 PM |
| Dere Willard H | Director | Dec 11, 2017 | Option Exercise | $1.52 | 12,500 | 19,000 | 0 | Dec 11, 2017, 03:19 PM |
| VANLENT ANNE | Director | Dec 11, 2017 | Option Exercise | $1.52 | 12,500 | 19,000 | 0 | Dec 11, 2017, 03:19 PM |
| WEBER ECKARD | Director | Dec 11, 2017 | Option Exercise | $1.52 | 356,688 | 542,166 | 0 | Dec 11, 2017, 03:19 PM |
| WEBER ECKARD | Director | Dec 11, 2017 | Option Exercise | $1.52 | 12,500 | 19,000 | 0 | Dec 11, 2017, 03:19 PM |
| WIERENGA WENDALL | Director | Dec 11, 2017 | Option Exercise | $1.52 | 17,500 | 26,600 | 0 | Dec 11, 2017, 03:18 PM |
| Byrnes Michael | CFO and Treasurer | Mar 28, 2017 | Buy | $1.28 | 3,000 | 3,854 | 13,000 | Mar 28, 2017, 04:06 PM |
| POWELL MICHAEL | Director | Sep 12, 2016 | Sale | $2.29 | 6,512 | 14,926 | 699,996 | Dec 30, 2016, 06:51 PM |
| POWELL MICHAEL | Director | Sep 12, 2016 | Option Exercise | $0.67 | 22,264 | 14,917 | 705,368 | Dec 30, 2016, 06:51 PM |
| Grais Linda S | President and CEO | Dec 07, 2016 | Buy | $2.14 | 7,000 | 14,980 | 70,000 | Dec 08, 2016, 04:18 PM |
| Bukofzer Stan | Chief Medical Officer | Oct 13, 2016 | Buy | $2.64 | 2,500 | 6,597 | 2,500 | Oct 17, 2016, 08:28 AM |
| POWELL MICHAEL | Director | Jul 11, 2016 | Option Exercise | $1.26 | 11,969 | 15,081 | 11,969 | Jul 13, 2016, 08:32 PM |
| Grais Linda S | President and CEO | Mar 04, 2016 | Buy | $3.19 | 3,000 | 9,570 | 63,000 | Mar 07, 2016, 08:08 AM |
| Grais Linda S | President and CEO | Jan 22, 2016 | Buy | $2.38 | 10,000 | 23,800 | 60,000 | Jan 25, 2016, 05:19 PM |
| Grais Linda S | President and CEO | Jan 15, 2016 | Buy | $2.08 | 10,000 | 20,800 | 50,000 | Jan 19, 2016, 08:14 AM |
| Byrnes Michael | CFO and Treasurer | Jan 15, 2016 | Buy | $2.07 | 3,500 | 7,245 | 10,000 | Jan 19, 2016, 08:14 AM |
| Aggarwal Gaurav | Chief Business Officer | Jan 15, 2016 | Buy | $2.15 | 10,000 | 21,500 | 20,000 | Jan 19, 2016, 08:14 AM |
| WEBER ECKARD | Director | Jan 04, 2016 | Option Exercise | $0.92 | 11,969 | 11,011 | 356,688 | Jan 06, 2016, 04:03 PM |
| WIERENGA WENDALL | Director | Jun 23, 2015 | Buy | $3.71 | 5,000 | 18,550 | 5,000 | Jun 24, 2015, 04:44 PM |
| Patni Rajiv | Chief Development Officer | May 07, 2015 | Buy | $3.97 | 5,050 | 20,049 | 5,050 | May 07, 2015, 05:19 PM |
| Grais Linda S | President and CEO | May 06, 2015 | Buy | $3.73 | 30,000 | 111,900 | 40,000 | May 06, 2015, 06:03 PM |
| Byrnes Michael | CFO and Treasurer | May 06, 2015 | Buy | $3.61 | 2,500 | 9,025 | 6,500 | May 06, 2015, 06:03 PM |
| Aggarwal Gaurav | Chief Business Officer | May 06, 2015 | Buy | $3.62 | 7,500 | 27,150 | 10,000 | May 06, 2015, 06:02 PM |
| Byrnes Michael | VP, Finance & Treasurer | Oct 01, 2014 | Buy | $4.81 | 2,000 | 9,620 | 4,000 | Oct 02, 2014, 04:16 PM |
| TETLOW SHARON | Acting CFO & Treasurer | Jul 11, 2014 | Buy | $5.83 | 3,000 | 17,487 | 3,000 | Jul 15, 2014, 04:05 PM |
| Grais Linda S | President and CEO | Jul 11, 2014 | Buy | $5.93 | 10,000 | 59,280 | 10,000 | Jul 15, 2014, 04:05 PM |
| VITULLO NICOLE | 10% Owner | Jul 15, 2013 | Buy | $6.03 | 7,333 | 44,192 | 7,333 | Jul 31, 2013, 05:54 PM |
| VITULLO NICOLE | 10% Owner | Jul 15, 2013 | Buy | $6.03 | 988,285 | 5,955,801 | 988,285 | Jul 31, 2013, 05:54 PM |
| VITULLO NICOLE | 10% Owner | Jul 15, 2013 | Buy | $6.03 | 331,873 | 1,999,999 | 1,857,036 | Jul 31, 2013, 05:54 PM |
| Domain Partners VI, L.P. | 10% Owner | Jul 15, 2013 | Buy | $6.03 | 331,873 | 1,999,999 | 1,857,036 | Jul 31, 2013, 05:47 PM |
| TREU JESSE I | 10% Owner | Jul 15, 2013 | Buy | $6.03 | 331,873 | 1,999,999 | 1,857,036 | Jul 31, 2013, 05:37 PM |
| TREU JESSE I | 10% Owner | Jul 15, 2013 | Buy | $6.03 | 7,333 | 44,192 | 7,333 | Jul 31, 2013, 05:37 PM |
| TREU JESSE I | 10% Owner | Jul 15, 2013 | Buy | $6.03 | 988,285 | 5,955,801 | 988,285 | Jul 31, 2013, 05:37 PM |
| SCHOEMAKER KATHLEEN K | 10% Owner | Jul 15, 2013 | Buy | $6.03 | 7,333 | 44,192 | 7,333 | Jul 31, 2013, 05:26 PM |
| SCHOEMAKER KATHLEEN K | 10% Owner | Jul 15, 2013 | Buy | $6.03 | 988,285 | 5,955,801 | 988,285 | Jul 31, 2013, 05:26 PM |
| SCHOEMAKER KATHLEEN K | 10% Owner | Jul 15, 2013 | Buy | $6.03 | 331,873 | 1,999,999 | 1,857,036 | Jul 31, 2013, 05:26 PM |
| DOVEY BRIAN H | 10% Owner | Jul 15, 2013 | Buy | $6.03 | 331,873 | 1,999,999 | 1,857,036 | Jul 31, 2013, 05:15 PM |
| DOVEY BRIAN H | 10% Owner | Jul 15, 2013 | Buy | $6.03 | 7,333 | 44,192 | 7,333 | Jul 31, 2013, 05:15 PM |
| DOVEY BRIAN H | 10% Owner | Jul 15, 2013 | Buy | $6.03 | 988,285 | 5,955,801 | 988,285 | Jul 31, 2013, 05:15 PM |
| BLAIR JAMES C | 10% Owner | Jul 15, 2013 | Buy | $6.03 | 331,873 | 1,999,999 | 1,857,036 | Jul 31, 2013, 05:00 PM |
| BLAIR JAMES C | 10% Owner | Jul 15, 2013 | Buy | $6.03 | 7,333 | 44,192 | 7,333 | Jul 31, 2013, 05:00 PM |
| BLAIR JAMES C | 10% Owner | Jul 15, 2013 | Buy | $6.03 | 988,285 | 5,955,801 | 988,285 | Jul 31, 2013, 05:00 PM |
| Halak Brian K | 10% Owner | Jul 15, 2013 | Buy | $6.03 | 988,285 | 5,955,801 | 988,285 | Jul 25, 2013, 01:00 PM |
| Halak Brian K | 10% Owner | Jul 15, 2013 | Buy | $6.03 | 7,333 | 44,192 | 7,333 | Jul 25, 2013, 01:00 PM |
| THOMAS MCNERNEY & PARTNERS LP | 10% Owner | Jul 15, 2013 | Option Exercise | $6.00 | 762,892 | 4,577,352 | 762,892 | Jul 17, 2013, 06:44 PM |
| THOMAS MCNERNEY & PARTNERS LP | 10% Owner | Jul 15, 2013 | Option Exercise | $6.00 | 1,675,677 | 10,054,062 | 1,675,677 | Jul 17, 2013, 06:44 PM |
| Thomas, McNerney & Partners II L.P. | 10% Owner | Jul 15, 2013 | Option Exercise | $6.00 | 1,751,393 | 10,508,358 | 1,751,393 | Jul 17, 2013, 06:41 PM |
| Thomas, McNerney & Partners II L.P. | 10% Owner | Jul 15, 2013 | Option Exercise | $6.00 | 687,176 | 4,123,056 | 687,176 | Jul 17, 2013, 06:41 PM |
| Zisson Alex | Formerly a director | Jul 15, 2013 | Option Exercise | $6.00 | 2,500,002 | 15,000,012 | 2,500,002 | Jul 17, 2013, 05:58 PM |
| POWELL MICHAEL | Director | Jul 15, 2013 | Buy | $6.03 | 391,166 | 2,357,323 | 1,025,364 | Jul 17, 2013, 05:49 PM |
| SOFINNOVA VENTURE PARTNERS VI L P | 10% Owner | Jul 15, 2013 | Buy | $6.03 | 391,166 | 2,357,323 | 1,025,364 | Jul 17, 2013, 05:47 PM |
| Kjellson Nina S | Director | Jul 15, 2013 | Buy | $6.03 | 431,435 | 2,600,000 | 825,826 | Jul 17, 2013, 04:12 PM |
| Domain Partners VI, L.P. | 10% Owner | Jul 15, 2013 | Buy | $6.03 | 331,873 | 1,999,999 | 1,897,336 | Jul 16, 2013, 08:41 PM |
| DOVEY BRIAN H | 10% Owner | Jul 15, 2013 | Buy | $6.03 | 7,333 | 44,192 | 7,333 | Jul 16, 2013, 08:34 PM |
| DOVEY BRIAN H | 10% Owner | Jul 15, 2013 | Buy | $6.03 | 331,873 | 1,999,999 | 1,897,336 | Jul 16, 2013, 08:34 PM |
| DOVEY BRIAN H | 10% Owner | Jul 15, 2013 | Buy | $6.03 | 988,285 | 5,955,801 | 988,285 | Jul 16, 2013, 08:34 PM |
| Halak Brian K | 10% Owner | Jul 15, 2013 | Buy | $6.03 | 331,873 | 1,999,999 | 1,897,336 | Jul 16, 2013, 08:30 PM |
| Halak Brian K | 10% Owner | Jul 15, 2013 | Buy | $6.03 | 7,333 | 44,192 | 7,333 | Jul 16, 2013, 08:30 PM |
| Halak Brian K | 10% Owner | Jul 15, 2013 | Buy | $6.03 | 988,285 | 5,955,801 | 988,285 | Jul 16, 2013, 08:30 PM |
| BLAIR JAMES C | 10% Owner | Jul 15, 2013 | Buy | $6.03 | 7,333 | 44,192 | 7,333 | Jul 16, 2013, 08:26 PM |
| BLAIR JAMES C | 10% Owner | Jul 15, 2013 | Buy | $6.03 | 988,285 | 5,955,801 | 988,285 | Jul 16, 2013, 08:26 PM |
| BLAIR JAMES C | 10% Owner | Jul 15, 2013 | Buy | $6.03 | 331,873 | 1,999,999 | 1,897,336 | Jul 16, 2013, 08:26 PM |
| SCHOEMAKER KATHLEEN K | 10% Owner | Jul 15, 2013 | Buy | $6.03 | 331,873 | 1,999,999 | 1,897,336 | Jul 16, 2013, 08:21 PM |
| SCHOEMAKER KATHLEEN K | 10% Owner | Jul 15, 2013 | Buy | $6.03 | 7,333 | 44,192 | 7,333 | Jul 16, 2013, 08:21 PM |
| SCHOEMAKER KATHLEEN K | 10% Owner | Jul 15, 2013 | Buy | $6.03 | 988,285 | 5,955,801 | 988,285 | Jul 16, 2013, 08:21 PM |
| TREU JESSE I | 10% Owner | Jul 15, 2013 | Buy | $6.03 | 7,333 | 44,192 | 7,333 | Jul 16, 2013, 08:16 PM |
| TREU JESSE I | 10% Owner | Jul 15, 2013 | Buy | $6.03 | 988,285 | 5,955,801 | 988,285 | Jul 16, 2013, 08:16 PM |
| TREU JESSE I | 10% Owner | Jul 15, 2013 | Buy | $6.03 | 331,873 | 1,999,999 | 1,897,336 | Jul 16, 2013, 08:16 PM |
| VITULLO NICOLE | 10% Owner | Jul 15, 2013 | Buy | $6.03 | 331,873 | 1,999,999 | 1,897,336 | Jul 16, 2013, 08:12 PM |
| VITULLO NICOLE | 10% Owner | Jul 15, 2013 | Buy | $6.03 | 7,333 | 44,192 | 7,333 | Jul 16, 2013, 08:12 PM |
| VITULLO NICOLE | 10% Owner | Jul 15, 2013 | Buy | $6.03 | 988,285 | 5,955,801 | 988,285 | Jul 16, 2013, 08:12 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | 10% Owner | Mar 12, 2012 | Buy | $2.44 | 961,299 | 2,341,269 | 3,290,162 | Mar 14, 2012, 05:37 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | 10% Owner | Mar 14, 2012 | Buy | $3.00 | 90,838 | 272,090 | 3,540,015 | Mar 14, 2012, 05:37 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | 10% Owner | Mar 13, 2012 | Buy | $2.96 | 159,015 | 470,382 | 3,449,177 | Mar 14, 2012, 05:37 PM |
| Baker Biotech Capital (GP), LLC | 10% Owner | Mar 14, 2012 | Buy | $3.00 | 12,076 | 36,172 | 232,011 | Mar 14, 2012, 05:35 PM |
| Baker Biotech Capital (GP), LLC | 10% Owner | Mar 13, 2012 | Buy | $2.96 | 15,599 | 46,143 | 219,935 | Mar 14, 2012, 05:35 PM |
| Baker Biotech Capital (GP), LLC | 10% Owner | Mar 12, 2012 | Buy | $2.44 | 94,306 | 229,685 | 204,336 | Mar 14, 2012, 05:35 PM |
| 14159 capital (GP), LLC | 10% Owner | Mar 14, 2012 | Buy | $3.00 | 2,392 | 7,165 | 57,704 | Mar 14, 2012, 05:34 PM |
| 14159 capital (GP), LLC | 10% Owner | Mar 13, 2012 | Buy | $2.96 | 4,186 | 12,383 | 55,312 | Mar 14, 2012, 05:34 PM |
| 14159 capital (GP), LLC | 10% Owner | Mar 12, 2012 | Buy | $2.44 | 25,304 | 61,629 | 51,126 | Mar 14, 2012, 05:34 PM |
| Moore David | VP, Commercial Operations | Sep 30, 2011 | Buy | $2.58 | 1,050 | 2,709 | 1,050 | Oct 04, 2011, 04:39 PM |
| QUAKER BIO VENTURES LP | 10% Owner | Apr 06, 2011 | Buy | $4.00 | 375,000 | 1,500,000 | 2,564,791 | Apr 06, 2011, 05:14 PM |
| BDC CAPITAL INC. | 10% Owner | Apr 06, 2011 | Buy | $4.00 | 1,000,000 | 4,000,000 | 2,238,825 | Apr 06, 2011, 05:11 PM |
| H.I.G. Ventures - Tranzyme, LLC | 10% Owner | Apr 06, 2011 | Buy | $4.00 | 812,500 | 3,250,000 | 3,002,291 | Apr 06, 2011, 05:10 PM |
| THOMAS MCNERNEY & PARTNERS LP | 10% Owner | Apr 06, 2011 | Buy | $4.00 | 2,966 | 11,864 | 3,002,286 | Apr 06, 2011, 05:01 PM |
| THOMAS MCNERNEY & PARTNERS LP | 10% Owner | Apr 06, 2011 | Buy | $4.00 | 14,568 | 58,272 | 2,999,320 | Apr 06, 2011, 05:01 PM |
| THOMAS MCNERNEY & PARTNERS LP | 10% Owner | Apr 06, 2011 | Buy | $4.00 | 794,966 | 3,179,864 | 2,984,752 | Apr 06, 2011, 05:01 PM |
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