Seagen Inc. (SGEN) NASDAQ
$193.45 -0.05 (-0.02%)
Market Cap: $36.28B
As of 05/30/23 11:20 AM EDT. Market open.
Seagen Inc. (SGEN)
NASDAQ
$193.45
-0.05 (-0.02%)
Market Cap: $36.28B
As of 05/30/23 11:20 AM EDT. Market open.
Seagen Inc. is a global biotechnology company that discovers, develops and commercializes transformative cancer medicines to make a meaningful difference in people’s lives. Seagen is headquartered in the Seattle, Washington area, and has locations in California, Canada, Switzerland and the European ... read more
Seagen Inc. is a global biotechnology company that discovers, develops and commercializes transformative cancer medicines to make a meaningful difference in people’s lives. Seagen is headquartered in the Seattle, Washington area, and has locations in California, Canada, Switzerland and the European Union. read less
COMPANY PROFILE
Sector
Manufacturing
Industry
Biological Product (except Diagnostic) Manufacturing
CEO Compensation (Base)
$918,554
CEO Compensation (Total)
$18.11M
Sector
Manufacturing
Industry
Biological Product (except Diagnostic) Manufacturing
Full Time Employees
3,256
CEO Compensation (Base)
$918,554
CEO Compensation (Total)
$18.11M
URL
Address
.
PRICE CHART FOR SEAGEN INC
From:
To:
NEWS
KEY STATS
Open
$192.90
Previous Close
$193.49
Days Range
$192.50 - $195.74
52 week range
$116.08 - $207.17
Volume
195,815
Avg. Volume (30 days)
1,682,206
Market Cap
$36.28B
Dividend Yield
0.00%
P/E
-55.94
Shares Outstanding
187,503,979
Open
$192.90
Previous Close
$193.49
Days Range
$192.50 - $195.74
52 week range
$116.08 - $207.17
Volume
195,815
Avg. Volume (30 days)
1,682,206
Market Cap
$36.28B
Dividend Yield
0.00%
P/E
-55.94
Shares Outstanding
187,503,979
Open in: 
Open in:
INSIDER TRANSACTIONS FOR SEAGEN INC
| Owner | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| ROMP CHARLES R | EVP, Commercial U.S. | May 16, 2023 | Sale | $189.86 | 349 | 66,261 | 59,777 | May 18, 2023, 07:04 PM |
| WELCH DANIEL G | Director | May 15, 2023 | Option Exercise | $135.63 | 1,864 | 252,814 | 8,117 | May 16, 2023, 07:23 PM |
| WELCH DANIEL G | Director | May 15, 2023 | Sale | $200.02 | 1,864 | 372,837 | 6,253 | May 16, 2023, 07:23 PM |
| WELCH DANIEL G | Director | May 02, 2023 | Option Exercise | $133.86 | 8,521 | 1,140,601 | 10,066 | May 03, 2023, 09:16 PM |
| WELCH DANIEL G | Director | May 01, 2023 | Option Exercise | $62.26 | 7,140 | 444,529 | 12,049 | May 03, 2023, 09:16 PM |
| WELCH DANIEL G | Director | May 02, 2023 | Sale | $200.07 | 8,872 | 1,775,024 | 6,604 | May 03, 2023, 09:16 PM |
| WELCH DANIEL G | Director | May 01, 2023 | Sale | $200.06 | 4,890 | 978,293 | 18,170 | May 03, 2023, 09:16 PM |
| WELCH DANIEL G | Director | May 01, 2023 | Sale | $200.06 | 7,435 | 1,487,462 | 6,899 | May 03, 2023, 09:16 PM |
| WELCH DANIEL G | Director | May 02, 2023 | Sale | $200.07 | 5,835 | 1,167,408 | 12,335 | May 03, 2023, 09:16 PM |
| BAKER BROS. ADVISORS LP | Director | May 01, 2023 | Option Exercise | $36.70 | 17,500 | 642,250 | 42,975,257 | May 03, 2023, 04:04 PM |
| LIU JEAN I | Chief Legal Officer | Apr 17, 2023 | Option Exercise | $39.15 | 5,000 | 195,750 | 91,763 | Apr 19, 2023, 06:16 PM |
| LIU JEAN I | Chief Legal Officer | Apr 17, 2023 | Sale | $205.86 | 5,000 | 1,029,311 | 86,763 | Apr 19, 2023, 06:16 PM |
| DANSEY ROGER D | President, R&D & CMO | Apr 17, 2023 | Option Exercise | $72.64 | 10,000 | 726,400 | 109,389 | Apr 19, 2023, 06:14 PM |
| DANSEY ROGER D | President, R&D & CMO | Apr 17, 2023 | Sale | $205.95 | 10,000 | 2,059,488 | 99,389 | Apr 19, 2023, 06:14 PM |
| SIMPSON TODD E | Chief Financial Officer | Apr 10, 2023 | Option Exercise | $46.37 | 55,344 | 2,566,301 | 159,310 | Apr 12, 2023, 07:50 PM |
| SIMPSON TODD E | Chief Financial Officer | Apr 10, 2023 | Sale | $204.58 | 55,344 | 11,322,143 | 118,946 | Apr 12, 2023, 07:50 PM |
| SIMPSON TODD E | Chief Financial Officer | Apr 06, 2023 | Sale | $205.86 | 243 | 50,023 | 118,946 | Apr 07, 2023, 07:40 PM |
| ROMP CHARLES R | EVP, Commercial U.S. | Apr 06, 2023 | Sale | $205.86 | 133 | 27,379 | 60,126 | Apr 07, 2023, 07:38 PM |
| LIU JEAN I | Chief Legal Officer | Apr 06, 2023 | Sale | $205.86 | 174 | 35,819 | 86,763 | Apr 07, 2023, 07:36 PM |
| HIMES VAUGHN B | Chief Technical Officer | Apr 06, 2023 | Sale | $205.86 | 243 | 50,023 | 68,837 | Apr 07, 2023, 07:29 PM |
| DANSEY ROGER D | President, R&D & CMO | Apr 06, 2023 | Sale | $205.86 | 333 | 68,550 | 99,389 | Apr 07, 2023, 07:28 PM |
| WELCH DANIEL G | Director | Apr 03, 2023 | Option Exercise | $60.94 | 17,525 | 1,068,060 | 14,057 | Apr 05, 2023, 09:07 PM |
| WELCH DANIEL G | Director | Apr 03, 2023 | Sale | $201.61 | 10,725 | 2,162,296 | 19,936 | Apr 05, 2023, 09:07 PM |
| WELCH DANIEL G | Director | Apr 03, 2023 | Sale | $201.61 | 20,275 | 4,087,548 | 6,899 | Apr 05, 2023, 09:07 PM |
| LIU JEAN I | Chief Legal Officer | Mar 16, 2023 | Option Exercise | $39.15 | 5,000 | 195,750 | 90,113 | Mar 17, 2023, 04:57 PM |
| LIU JEAN I | Chief Legal Officer | Mar 16, 2023 | Sale | $199.90 | 5,000 | 999,500 | 85,113 | Mar 17, 2023, 04:57 PM |
| WELCH DANIEL G | Director | Mar 15, 2023 | Option Exercise | $38.82 | 2,037 | 79,076 | 9,256 | Mar 17, 2023, 04:43 PM |
| WELCH DANIEL G | Director | Mar 15, 2023 | Sale | $200.05 | 1,246 | 249,262 | 23,060 | Mar 17, 2023, 04:43 PM |
| WELCH DANIEL G | Director | Mar 15, 2023 | Sale | $200.05 | 2,357 | 471,518 | 7,219 | Mar 17, 2023, 04:43 PM |
| DANSEY ROGER D | President, R&D & CMO | Mar 15, 2023 | Option Exercise | $72.64 | 10,000 | 726,400 | 106,853 | Mar 17, 2023, 04:20 PM |
| DANSEY ROGER D | President, R&D & CMO | Mar 15, 2023 | Sale | $199.81 | 10,000 | 1,998,115 | 96,853 | Mar 17, 2023, 04:20 PM |
| WELCH DANIEL G | Director | Mar 13, 2023 | Option Exercise | $39.51 | 15,018 | 593,370 | 23,036 | Mar 16, 2023, 06:05 AM |
| WELCH DANIEL G | Director | Mar 14, 2023 | Option Exercise | $38.82 | 470 | 18,245 | 13,447 | Mar 16, 2023, 06:05 AM |
| WELCH DANIEL G | Director | Mar 14, 2023 | Sale | $200.00 | 288 | 57,600 | 24,306 | Mar 16, 2023, 06:05 AM |
| WELCH DANIEL G | Director | Mar 13, 2023 | Sale | $200.36 | 9,191 | 1,841,486 | 25,575 | Mar 16, 2023, 06:05 AM |
| WELCH DANIEL G | Director | Mar 14, 2023 | Sale | $200.00 | 544 | 108,800 | 12,977 | Mar 16, 2023, 06:05 AM |
| WELCH DANIEL G | Director | Mar 13, 2023 | Sale | $200.36 | 17,374 | 3,481,015 | 15,407 | Mar 16, 2023, 06:05 AM |
| SIMPSON TODD E | Chief Financial Officer | Mar 09, 2023 | Option Exercise | $45.30 | 42,793 | 1,938,523 | 159,978 | Mar 10, 2023, 04:11 PM |
| SIMPSON TODD E | Chief Financial Officer | Mar 09, 2023 | Sale | $176.61 | 42,793 | 7,557,550 | 149,716 | Mar 10, 2023, 04:11 PM |
| HIMES VAUGHN B | Chief Technical Officer | Mar 02, 2023 | Option Exercise | $41.04 | 16,215 | 665,464 | 80,781 | Mar 03, 2023, 05:36 PM |
| HIMES VAUGHN B | Chief Technical Officer | Mar 02, 2023 | Sale | $177.21 | 16,215 | 2,873,477 | 67,257 | Mar 03, 2023, 05:36 PM |
| SIMPSON TODD E | Chief Financial Officer | Feb 27, 2023 | Sale | $182.53 | 20,000 | 3,650,600 | 117,185 | Feb 28, 2023, 07:24 PM |
| SIMPSON TODD E | Chief Financial Officer | Feb 16, 2023 | Option Exercise | $39.15 | 39,946 | 1,563,886 | 177,131 | Feb 21, 2023, 07:35 PM |
| SIMPSON TODD E | Chief Financial Officer | Feb 16, 2023 | Sale | $160.00 | 39,946 | 6,391,400 | 137,185 | Feb 21, 2023, 07:35 PM |
| LIU JEAN I | Chief Legal Officer | Feb 16, 2023 | Option Exercise | $39.15 | 5,000 | 195,750 | 90,113 | Feb 21, 2023, 07:33 PM |
| LIU JEAN I | Chief Legal Officer | Feb 16, 2023 | Sale | $155.00 | 5,000 | 775,000 | 85,113 | Feb 21, 2023, 07:33 PM |
| DANSEY ROGER D | President, R&D & CMO | Feb 15, 2023 | Option Exercise | $72.64 | 10,000 | 726,400 | 106,853 | Feb 17, 2023, 04:23 PM |
| DANSEY ROGER D | President, R&D & CMO | Feb 15, 2023 | Sale | $140.64 | 10,000 | 1,406,395 | 106,653 | Feb 17, 2023, 04:23 PM |
| GRYSKA DAVID W | Director | Feb 13, 2023 | Option Exercise | $36.70 | 8,750 | 321,125 | 49,003 | Feb 15, 2023, 06:33 PM |
| DANSEY ROGER D | President, R&D & CMO | Feb 02, 2023 | Sale | $138.52 | 783 | 108,461 | 96,853 | Feb 03, 2023, 08:01 PM |
| DANSEY ROGER D | President, R&D & CMO | Jan 24, 2023 | Option Exercise | $72.64 | 10,000 | 726,400 | 107,539 | Jan 26, 2023, 07:41 PM |
| DANSEY ROGER D | President, R&D & CMO | Jan 24, 2023 | Sale | $135.00 | 10,000 | 1,350,000 | 97,539 | Jan 26, 2023, 07:41 PM |
| LIU JEAN I | Chief Legal Officer | Jan 24, 2023 | Option Exercise | $39.15 | 5,000 | 195,750 | 90,113 | Jan 26, 2023, 07:39 PM |
| LIU JEAN I | Chief Legal Officer | Jan 24, 2023 | Sale | $135.03 | 5,000 | 675,134 | 85,113 | Jan 26, 2023, 07:39 PM |
| LIU JEAN I | Chief Legal Officer | Jan 17, 2023 | Sale | $130.71 | 578 | 75,548 | 85,113 | Jan 19, 2023, 07:16 PM |
| DANSEY ROGER D | President R&D & CMO | Jan 05, 2023 | Option Exercise | $72.64 | 7,500 | 544,800 | 105,039 | Jan 06, 2023, 07:10 PM |
| DANSEY ROGER D | President R&D & CMO | Jan 04, 2023 | Option Exercise | $72.64 | 2,500 | 181,600 | 100,039 | Jan 06, 2023, 07:10 PM |
| DANSEY ROGER D | President R&D & CMO | Jan 04, 2023 | Sale | $135.00 | 2,500 | 337,500 | 97,539 | Jan 06, 2023, 07:10 PM |
| DANSEY ROGER D | President R&D & CMO | Jan 05, 2023 | Sale | $135.00 | 7,500 | 1,012,500 | 97,539 | Jan 06, 2023, 07:10 PM |
| LIU JEAN I | Chief Legal Officer | Jan 04, 2023 | Option Exercise | $39.15 | 475 | 18,596 | 86,166 | Jan 06, 2023, 07:08 PM |
| LIU JEAN I | Chief Legal Officer | Jan 05, 2023 | Option Exercise | $39.15 | 4,525 | 177,154 | 90,216 | Jan 06, 2023, 07:08 PM |
| LIU JEAN I | Chief Legal Officer | Jan 05, 2023 | Sale | $135.00 | 4,525 | 610,875 | 85,691 | Jan 06, 2023, 07:08 PM |
| LIU JEAN I | Chief Legal Officer | Jan 04, 2023 | Sale | $135.00 | 475 | 64,125 | 85,691 | Jan 06, 2023, 07:08 PM |
| ROMP CHARLES R | EVP, Commercial U.S. | Dec 20, 2022 | Sale | $127.63 | 1,129 | 144,094 | 58,475 | Dec 21, 2022, 06:48 PM |
| DANSEY ROGER D | President, Research and Develo | Dec 14, 2022 | Option Exercise | $77.16 | 10,000 | 771,628 | 106,942 | Dec 16, 2022, 07:42 PM |
| DANSEY ROGER D | President, Research and Develo | Dec 14, 2022 | Sale | $135.00 | 10,000 | 1,350,000 | 97,539 | Dec 16, 2022, 07:42 PM |
| Simonian Nancy A | Director | Dec 12, 2022 | Option Exercise | $36.70 | 8,750 | 321,125 | 62,753 | Dec 14, 2022, 05:49 PM |
| LIU JEAN I | Chief Legal Officer | Nov 17, 2022 | Option Exercise | $34.20 | 8,333 | 284,989 | 94,024 | Nov 18, 2022, 07:53 PM |
| LIU JEAN I | Chief Legal Officer | Nov 17, 2022 | Sale | $131.05 | 8,333 | 1,092,056 | 85,691 | Nov 18, 2022, 07:53 PM |
| LIU JEAN I | Chief Legal Officer | Nov 14, 2022 | Option Exercise | $76.86 | 1,301 | 99,995 | 85,691 | Nov 16, 2022, 06:22 PM |
| GRYSKA DAVID W | Director | Nov 11, 2022 | Sale | $129.10 | 7,500 | 968,220 | 40,253 | Nov 15, 2022, 05:46 PM |
| DANSEY ROGER D | Interim CEO & CMO | Oct 17, 2022 | Option Exercise | $74.54 | 10,000 | 745,421 | 102,146 | Oct 19, 2022, 07:17 PM |
| DANSEY ROGER D | Interim CEO & CMO | Oct 17, 2022 | Sale | $135.00 | 10,000 | 1,350,000 | 97,539 | Oct 19, 2022, 07:17 PM |
| SIMPSON TODD E | Chief Financial Officer | Aug 31, 2022 | Sale | $154.41 | 4,186 | 646,381 | 139,249 | Sep 01, 2022, 06:09 PM |
| HIMES VAUGHN B | Chief Technical Officer | Aug 31, 2022 | Sale | $154.41 | 3,584 | 553,423 | 68,972 | Sep 01, 2022, 06:07 PM |
| ROMP CHARLES R | EVP, Commercial | Aug 31, 2022 | Sale | $154.41 | 1,133 | 174,952 | 60,159 | Sep 01, 2022, 06:06 PM |
| DANSEY ROGER D | Interim CEO & CMO | Aug 31, 2022 | Sale | $154.41 | 5,019 | 775,009 | 101,752 | Sep 01, 2022, 06:03 PM |
| LIU JEAN I | Chief Legal Officer | Aug 31, 2022 | Sale | $154.41 | 3,648 | 563,306 | 86,283 | Sep 01, 2022, 06:03 PM |
| SIMPSON TODD E | Chief Financial Officer | Aug 16, 2022 | Sale | $170.21 | 1,967 | 334,813 | 142,477 | Aug 17, 2022, 09:19 PM |
| ROMP CHARLES R | EVP, Commercial | Aug 16, 2022 | Sale | $170.21 | 1,765 | 300,429 | 61,725 | Aug 17, 2022, 09:16 PM |
| LIU JEAN I | Chief Legal Officer | Aug 16, 2022 | Sale | $170.21 | 1,639 | 278,982 | 88,755 | Aug 17, 2022, 09:14 PM |
| HIMES VAUGHN B | Chief Technical Officer | Aug 16, 2022 | Sale | $170.21 | 1,527 | 259,918 | 71,636 | Aug 17, 2022, 09:13 PM |
| DANSEY ROGER D | Interim CEO & CMO | Aug 16, 2022 | Sale | $170.21 | 4,254 | 724,095 | 104,406 | Aug 17, 2022, 09:12 PM |
| ROMP CHARLES R | EVP, Commercial | Jul 05, 2022 | Sale | $179.46 | 712 | 127,776 | 48,771 | Jul 07, 2022, 06:50 PM |
| DANSEY ROGER D | Chief Medical Officer | Jun 28, 2022 | Option Exercise | $65.11 | 19,744 | 1,285,532 | 94,336 | Jun 30, 2022, 06:02 PM |
| DANSEY ROGER D | Chief Medical Officer | Jun 28, 2022 | Sale | $180.00 | 34,635 | 6,234,300 | 76,975 | Jun 30, 2022, 06:02 PM |
| HIMES VAUGHN B | Chief Technical Officer | Jun 17, 2022 | Option Exercise | $41.04 | 1,134 | 46,539 | 60,198 | Jun 22, 2022, 07:03 PM |
| HIMES VAUGHN B | Chief Technical Officer | Jun 17, 2022 | Sale | $160.00 | 1,134 | 181,440 | 119,471 | Jun 22, 2022, 07:03 PM |
| HIMES VAUGHN B | Chief Technical Officer | May 24, 2022 | Option Exercise | $26.10 | 10,866 | 283,603 | 67,359 | May 26, 2022, 06:07 PM |
| HIMES VAUGHN B | Chief Technical Officer | May 24, 2022 | Sale | $136.79 | 10,866 | 1,486,376 | 59,064 | May 26, 2022, 06:07 PM |
| ROMP CHARLES R | EVP, Commercial | May 16, 2022 | Sale | $134.21 | 333 | 44,691 | 49,483 | May 18, 2022, 07:34 PM |
| SIEGALL CLAY B | President & CEO | May 12, 2022 | Option Exercise | $26.10 | 17,043 | 444,822 | 676,653 | May 13, 2022, 07:13 PM |
| SIEGALL CLAY B | President & CEO | May 12, 2022 | Sale | $125.69 | 17,043 | 2,142,117 | 666,060 | May 13, 2022, 07:13 PM |
| SIEGALL CLAY B | President & CEO | Apr 20, 2022 | Sale | $144.32 | 1,885 | 272,041 | 666,060 | Apr 22, 2022, 08:34 PM |
| SIMPSON TODD E | Chief Financial Officer | Apr 20, 2022 | Sale | $144.32 | 567 | 81,829 | 127,891 | Apr 22, 2022, 08:32 PM |
| LIU JEAN I | Chief Legal Officer | Apr 20, 2022 | Sale | $144.32 | 401 | 57,872 | 75,946 | Apr 22, 2022, 08:31 PM |
| ROMP CHARLES R | EVP, Commercial | Apr 20, 2022 | Sale | $144.32 | 319 | 46,038 | 49,816 | Apr 22, 2022, 08:30 PM |
| HIMES VAUGHN B | Chief Technical Officer | Apr 20, 2022 | Sale | $144.32 | 574 | 82,839 | 59,064 | Apr 22, 2022, 08:29 PM |
| DANSEY ROGER D | Chief Medical Officer | Apr 21, 2022 | Sale | $144.15 | 652 | 93,986 | 76,975 | Apr 22, 2022, 08:27 PM |
| DANSEY ROGER D | Chief Medical Officer | Apr 20, 2022 | Sale | $144.32 | 787 | 113,579 | 77,627 | Apr 22, 2022, 08:27 PM |
| GRYSKA DAVID W | Director | Apr 19, 2022 | Option Exercise | $20.06 | 4,000 | 80,240 | 48,044 | Apr 21, 2022, 06:37 PM |
| GRYSKA DAVID W | Director | Apr 19, 2022 | Sale | $143.95 | 4,000 | 575,783 | 46,250 | Apr 21, 2022, 06:37 PM |
| SIEGALL CLAY B | President and CEO | Apr 07, 2022 | Option Exercise | $26.10 | 17,043 | 444,822 | 672,637 | Apr 08, 2022, 09:41 PM |
| SIEGALL CLAY B | President and CEO | Apr 07, 2022 | Sale | $154.23 | 17,043 | 2,628,610 | 667,945 | Apr 08, 2022, 09:41 PM |
| BAKER BROS. ADVISORS LP | Director | Mar 08, 2022 | Option Exercise | $20.06 | 35,000 | 702,100 | 42,965,004 | Mar 10, 2022, 04:39 PM |
| SIEGALL CLAY B | President & CEO | Mar 07, 2022 | Option Exercise | $26.10 | 17,043 | 444,822 | 674,588 | Mar 09, 2022, 07:42 PM |
| SIEGALL CLAY B | President & CEO | Mar 07, 2022 | Sale | $134.35 | 17,043 | 2,289,655 | 667,945 | Mar 09, 2022, 07:42 PM |
| HIMES VAUGHN B | Chief Technical Officer | Mar 03, 2022 | Option Exercise | $26.10 | 12,000 | 313,200 | 70,343 | Mar 04, 2022, 07:24 PM |
| HIMES VAUGHN B | Chief Technical Officer | Mar 03, 2022 | Sale | $127.05 | 12,000 | 1,524,558 | 59,500 | Mar 04, 2022, 07:24 PM |
| Simonian Nancy A | Director | Mar 02, 2022 | Option Exercise | $20.04 | 25,000 | 501,000 | 52,500 | Mar 04, 2022, 05:09 PM |
| SIEGALL CLAY B | President & CEO | Feb 07, 2022 | Option Exercise | $26.10 | 17,043 | 444,822 | 676,930 | Feb 09, 2022, 07:02 PM |
| SIEGALL CLAY B | President & CEO | Feb 07, 2022 | Sale | $139.97 | 17,043 | 2,385,566 | 667,945 | Feb 09, 2022, 07:02 PM |
| GRYSKA DAVID W | Director | Feb 07, 2022 | Option Exercise | $20.06 | 4,500 | 90,270 | 48,621 | Feb 09, 2022, 06:58 PM |
| GRYSKA DAVID W | Director | Feb 07, 2022 | Sale | $138.76 | 4,500 | 624,441 | 46,250 | Feb 09, 2022, 06:58 PM |
| DANSEY ROGER D | Chief Medical Officer | Feb 03, 2022 | Sale | $136.14 | 703 | 95,706 | 78,244 | Feb 04, 2022, 05:54 PM |
| DANSEY ROGER D | Chief Medical Officer | Feb 02, 2022 | Sale | $137.58 | 739 | 101,672 | 78,947 | Feb 04, 2022, 05:54 PM |
| GRYSKA DAVID W | Director | Jan 28, 2022 | Option Exercise | $20.06 | 4,500 | 90,270 | 48,803 | Feb 01, 2022, 06:42 PM |
| GRYSKA DAVID W | Director | Jan 28, 2022 | Sale | $122.56 | 4,500 | 551,539 | 46,250 | Feb 01, 2022, 06:42 PM |
| GRYSKA DAVID W | Director | Jan 14, 2022 | Option Exercise | $20.06 | 4,500 | 90,270 | 50,750 | Jan 19, 2022, 06:26 PM |
| GRYSKA DAVID W | Director | Jan 14, 2022 | Sale | $135.24 | 4,500 | 608,580 | 46,250 | Jan 19, 2022, 06:26 PM |
| SIEGALL CLAY B | President & CEO | Jan 07, 2022 | Option Exercise | $26.10 | 17,044 | 444,848 | 676,108 | Jan 11, 2022, 07:14 PM |
| SIEGALL CLAY B | President & CEO | Jan 07, 2022 | Sale | $144.73 | 17,044 | 2,466,743 | 667,945 | Jan 11, 2022, 07:14 PM |
| DANSEY ROGER D | Chief Medical Officer | Jan 03, 2022 | Sale | $152.58 | 8,675 | 1,323,649 | 84,891 | Jan 05, 2022, 05:32 PM |
| ROMP CHARLES R | EVP, Commercial | Dec 20, 2021 | Sale | $149.85 | 1,323 | 198,252 | 51,102 | Dec 22, 2021, 05:34 PM |
| HIMES VAUGHN B | Chief Technical Officer | Dec 20, 2021 | Sale | $149.85 | 345 | 51,698 | 59,500 | Dec 22, 2021, 05:33 PM |
| DANSEY ROGER D | Chief Medical Officer | Dec 20, 2021 | Sale | $149.85 | 280 | 41,958 | 88,641 | Dec 22, 2021, 05:33 PM |
| DANSEY ROGER D | Chief Medical Officer | Dec 21, 2021 | Sale | $155.58 | 280 | 43,562 | 88,361 | Dec 22, 2021, 05:33 PM |
| SIEGALL CLAY B | President & CEO | Dec 20, 2021 | Sale | $149.85 | 1,227 | 183,866 | 667,945 | Dec 22, 2021, 05:32 PM |
| SIMPSON TODD E | Chief Financial Officer | Dec 20, 2021 | Sale | $149.85 | 345 | 51,698 | 128,458 | Dec 22, 2021, 05:31 PM |
| LIU JEAN I | Chief Legal Officer | Dec 20, 2021 | Sale | $149.85 | 276 | 41,359 | 70,432 | Dec 22, 2021, 05:31 PM |
| SIEGALL CLAY B | President & CEO | Dec 07, 2021 | Option Exercise | $26.10 | 45,449 | 1,186,219 | 683,863 | Dec 09, 2021, 06:49 PM |
| SIEGALL CLAY B | President & CEO | Dec 07, 2021 | Sale | $148.66 | 45,449 | 6,756,632 | 669,172 | Dec 09, 2021, 06:49 PM |
| BAKER BROS. ADVISORS LP | Director | Nov 30, 2021 | Sale | $160.33 | 301,444 | 48,331,458 | 43,100,476 | Dec 02, 2021, 06:51 PM |
| BAKER BROS. ADVISORS LP | Director | Dec 01, 2021 | Sale | $161.21 | 93,451 | 15,064,917 | 43,007,235 | Dec 02, 2021, 06:51 PM |
| HIMES VAUGHN B | Chief Technical Officer | Nov 11, 2021 | Option Exercise | $26.10 | 6,000 | 156,600 | 65,845 | Nov 12, 2021, 06:51 PM |
| HIMES VAUGHN B | Chief Technical Officer | Nov 11, 2021 | Sale | $178.63 | 6,000 | 1,071,774 | 63,828 | Nov 12, 2021, 06:51 PM |
| LIU JEAN I | GC/EVP, Leg Affairs | Nov 04, 2021 | Option Exercise | $46.37 | 1,617 | 74,980 | 70,708 | Nov 05, 2021, 05:21 PM |
| SIMPSON TODD E | Chief Financial Officer | Nov 04, 2021 | Option Exercise | $46.37 | 2,156 | 99,974 | 128,803 | Nov 05, 2021, 05:21 PM |
| SIMPSON TODD E | Chief Financial Officer | Nov 03, 2021 | Option Exercise | $44.09 | 40,232 | 1,773,829 | 166,879 | Nov 05, 2021, 05:21 PM |
| SIMPSON TODD E | Chief Financial Officer | Nov 03, 2021 | Sale | $185.00 | 40,232 | 7,442,920 | 126,647 | Nov 05, 2021, 05:21 PM |
| LIU JEAN I | GC/EVP, Leg Afairs | Nov 01, 2021 | Option Exercise | $35.95 | 34,876 | 1,253,792 | 103,967 | Nov 03, 2021, 09:18 PM |
| LIU JEAN I | GC/EVP, Leg Afairs | Nov 01, 2021 | Sale | $177.41 | 34,876 | 6,187,369 | 101,887 | Nov 03, 2021, 09:18 PM |
| HIMES VAUGHN B | Chief Technical Officer | Nov 01, 2021 | Option Exercise | $46.37 | 2,156 | 99,974 | 59,845 | Nov 03, 2021, 07:20 PM |
| SIMPSON TODD E | Chief Financial Officer | Oct 29, 2021 | Option Exercise | $41.04 | 33,564 | 1,377,467 | 160,211 | Nov 02, 2021, 06:46 PM |
| SIMPSON TODD E | Chief Financial Officer | Oct 29, 2021 | Sale | $180.00 | 33,564 | 6,041,520 | 126,647 | Nov 02, 2021, 06:46 PM |
| SIMPSON TODD E | Chief Financial Officer | Sep 23, 2021 | Option Exercise | $166.22 | 201 | 33,410 | 126,647 | Sep 27, 2021, 08:10 PM |
| SIEGALL CLAY B | President & CEO | Sep 23, 2021 | Option Exercise | $166.22 | 714 | 118,681 | 669,172 | Sep 27, 2021, 08:10 PM |
| ROMP CHARLES R | EVP, Commercial | Sep 23, 2021 | Option Exercise | $166.22 | 112 | 18,617 | 51,296 | Sep 27, 2021, 08:10 PM |
| HIMES VAUGHN B | Chief Technical Officer | Sep 23, 2021 | Option Exercise | $166.22 | 201 | 33,410 | 57,689 | Sep 27, 2021, 08:09 PM |
| LIU JEAN I | GC/EVP, Legal Affairs | Sep 23, 2021 | Option Exercise | $166.22 | 160 | 26,595 | 69,091 | Sep 27, 2021, 08:09 PM |
| DANSEY ROGER D | Chief Medical Officer | Sep 23, 2021 | Option Exercise | $166.22 | 3,582 | 595,400 | 88,921 | Sep 27, 2021, 08:08 PM |
| HIMES VAUGHN B | Chief Technical Officer | Sep 08, 2021 | Option Exercise | $26.10 | 6,000 | 156,600 | 63,488 | Sep 10, 2021, 07:22 PM |
| HIMES VAUGHN B | Chief Technical Officer | Sep 08, 2021 | Sale | $150.00 | 6,000 | 900,000 | 57,488 | Sep 10, 2021, 07:22 PM |
| DANSEY ROGER D | Chief Medical Officer | Aug 31, 2021 | Sale | $167.52 | 4,611 | 772,416 | 86,249 | Sep 02, 2021, 08:07 PM |
| SIEGALL CLAY B | President & CEO | Aug 31, 2021 | Sale | $167.52 | 14,351 | 2,404,022 | 673,245 | Sep 02, 2021, 07:59 PM |
| LIU JEAN I | GC/EVP, Legal Affairs | Aug 31, 2021 | Sale | $167.52 | 3,648 | 611,098 | 70,686 | Sep 02, 2021, 07:58 PM |
| SIMPSON TODD E | Chief Financial Officer | Aug 31, 2021 | Sale | $167.52 | 3,987 | 667,886 | 128,568 | Sep 02, 2021, 07:57 PM |
| HIMES VAUGHN B | Chief Technical Officer | Aug 31, 2021 | Sale | $167.52 | 3,584 | 600,377 | 59,283 | Sep 02, 2021, 07:53 PM |
| ROMP CHARLES R | EVP, Commercial | Aug 31, 2021 | Sale | $167.52 | 1,133 | 189,796 | 51,739 | Sep 02, 2021, 07:49 PM |
| SIEGALL CLAY B | President and CEO | Aug 30, 2021 | Sale | $166.86 | 35,706 | 5,957,815 | 696,147 | Aug 31, 2021, 09:28 PM |
| SIEGALL CLAY B | President and CEO | Aug 27, 2021 | Sale | $169.05 | 14,294 | 2,416,390 | 731,028 | Aug 31, 2021, 09:28 PM |
| SIEGALL CLAY B | President and CEO | Aug 31, 2021 | Sale | $169.92 | 10,432 | 1,772,575 | 691,471 | Aug 31, 2021, 09:28 PM |
| ROMP CHARLES R | EVP, Commercial | Aug 16, 2021 | Sale | $154.55 | 777 | 120,088 | 42,410 | Aug 18, 2021, 08:29 PM |
| SIEGALL CLAY B | President & CEO | Aug 16, 2021 | Sale | $154.55 | 2,789 | 431,051 | 712,420 | Aug 18, 2021, 08:29 PM |
| HIMES VAUGHN B | Chief Technical Officer | Aug 16, 2021 | Sale | $154.55 | 658 | 101,697 | 52,354 | Aug 18, 2021, 08:29 PM |
| DANSEY ROGER D | Chief Medical Officer | Aug 16, 2021 | Sale | $154.55 | 1,657 | 256,096 | 72,778 | Aug 18, 2021, 08:28 PM |
| LIU JEAN I | GC/EVP, Leg Affairs | Aug 16, 2021 | Sale | $154.55 | 718 | 110,970 | 63,333 | Aug 18, 2021, 08:28 PM |
| SIMPSON TODD E | Chief Financial Officer | Aug 16, 2021 | Sale | $154.55 | 533 | 82,377 | 119,338 | Aug 18, 2021, 08:28 PM |
| DANSEY ROGER D | Chief Medical Officer | Aug 13, 2021 | Sale | $156.59 | 10,000 | 1,565,867 | 74,535 | Aug 13, 2021, 09:39 PM |
| SIEGALL CLAY B | President & CEO | Aug 05, 2021 | Option Exercise | $15.46 | 23,560 | 364,238 | 724,471 | Aug 06, 2021, 08:28 PM |
| SIEGALL CLAY B | President & CEO | Aug 06, 2021 | Option Exercise | $15.46 | 5,793 | 89,560 | 718,885 | Aug 06, 2021, 08:28 PM |
| SIEGALL CLAY B | President & CEO | Aug 06, 2021 | Sale | $159.70 | 5,793 | 925,134 | 715,209 | Aug 06, 2021, 08:28 PM |
| SIEGALL CLAY B | President & CEO | Aug 05, 2021 | Sale | $163.08 | 23,560 | 3,842,086 | 715,209 | Aug 06, 2021, 08:28 PM |
| SIEGALL CLAY B | President and CEO | Jul 02, 2021 | Option Exercise | $15.46 | 15,268 | 236,043 | 722,621 | Jul 06, 2021, 09:40 PM |
| SIEGALL CLAY B | President and CEO | Jul 01, 2021 | Option Exercise | $15.46 | 14,085 | 217,754 | 721,374 | Jul 06, 2021, 09:40 PM |
| SIEGALL CLAY B | President and CEO | Jul 02, 2021 | Sale | $156.36 | 15,268 | 2,387,233 | 715,209 | Jul 06, 2021, 09:40 PM |
| SIEGALL CLAY B | President and CEO | Jul 01, 2021 | Sale | $157.78 | 14,085 | 2,222,376 | 715,209 | Jul 06, 2021, 09:40 PM |
| ROMP CHARLES R | EVP, Commercial | Jul 02, 2021 | Sale | $158.41 | 703 | 111,362 | 43,187 | Jul 06, 2021, 08:13 PM |
| HIMES VAUGHN B | Chief Technical Officer | Jun 07, 2021 | Option Exercise | $26.10 | 1,303 | 34,008 | 54,315 | Jun 08, 2021, 08:50 PM |
| HIMES VAUGHN B | Chief Technical Officer | Jun 07, 2021 | Sale | $150.00 | 1,303 | 195,450 | 53,012 | Jun 08, 2021, 08:50 PM |
| SIEGALL CLAY B | President and CEO | Jun 03, 2021 | Option Exercise | $15.46 | 29,353 | 453,797 | 723,884 | Jun 04, 2021, 08:22 PM |
| SIEGALL CLAY B | President and CEO | Jun 03, 2021 | Sale | $144.51 | 29,353 | 4,241,801 | 715,209 | Jun 04, 2021, 08:22 PM |
| HIMES VAUGHN B | Chief Technical Officer | Jun 03, 2021 | Option Exercise | $15.46 | 10,697 | 165,376 | 63,709 | Jun 04, 2021, 08:21 PM |
| HIMES VAUGHN B | Chief Technical Officer | Jun 03, 2021 | Sale | $144.91 | 10,697 | 1,550,090 | 61,709 | Jun 04, 2021, 08:21 PM |
| LIU JEAN I | GC/EVP, Leg Affairs | May 11, 2021 | Sale | $140.00 | 1,061 | 148,540 | 64,051 | May 13, 2021, 07:17 PM |
| SIEGALL CLAY B | President and CEO | Apr 09, 2021 | Option Exercise | $15.46 | 12,602 | 194,827 | 721,310 | Apr 09, 2021, 08:13 PM |
| SIEGALL CLAY B | President and CEO | Apr 08, 2021 | Option Exercise | $15.46 | 16,751 | 258,970 | 724,376 | Apr 09, 2021, 08:13 PM |
| SIEGALL CLAY B | President and CEO | Apr 09, 2021 | Sale | $141.96 | 12,602 | 1,788,924 | 715,209 | Apr 09, 2021, 08:13 PM |
| SIEGALL CLAY B | President and CEO | Apr 08, 2021 | Sale | $145.17 | 16,751 | 2,431,816 | 715,209 | Apr 09, 2021, 08:13 PM |
| SIEGALL CLAY B | President and CEO | Mar 04, 2021 | Option Exercise | $15.46 | 29,353 | 453,797 | 726,618 | Mar 05, 2021, 07:56 PM |
| SIEGALL CLAY B | President and CEO | Mar 04, 2021 | Sale | $145.74 | 29,353 | 4,277,763 | 715,209 | Mar 05, 2021, 07:56 PM |
| HIMES VAUGHN B | Chief Technical Officer | Mar 02, 2021 | Option Exercise | $15.46 | 12,000 | 185,520 | 141,889 | Mar 04, 2021, 07:27 PM |
| HIMES VAUGHN B | Chief Technical Officer | Mar 02, 2021 | Sale | $153.22 | 12,000 | 1,838,623 | 138,889 | Mar 04, 2021, 07:27 PM |
| LIU JEAN I | GC/EVP, Leg Affairs | Feb 17, 2021 | Option Exercise | $41.37 | 4,846 | 200,466 | 65,112 | Feb 18, 2021, 08:48 PM |
| SIEGALL CLAY B | President and CEO | Feb 04, 2021 | Option Exercise | $15.46 | 29,353 | 453,797 | 726,706 | Feb 05, 2021, 08:00 PM |
| SIEGALL CLAY B | President and CEO | Feb 04, 2021 | Sale | $165.57 | 29,353 | 4,860,105 | 715,209 | Feb 05, 2021, 08:00 PM |
| DANSEY ROGER D | Chief Medical Officer | Feb 02, 2021 | Option Exercise | $163.97 | 728 | 119,370 | 109,544 | Feb 04, 2021, 08:08 PM |
| LIU JEAN I | GC/EVP, Leg Affairs | Jan 15, 2021 | Option Exercise | $35.95 | 5,000 | 179,750 | 65,266 | Jan 15, 2021, 07:40 PM |
| LIU JEAN I | GC/EVP, Leg Affairs | Jan 15, 2021 | Sale | $180.00 | 5,000 | 900,000 | 60,266 | Jan 15, 2021, 07:40 PM |
| SIEGALL CLAY B | President and CEO | Jan 07, 2021 | Option Exercise | $15.46 | 29,353 | 453,797 | 719,687 | Jan 08, 2021, 07:52 PM |
| SIEGALL CLAY B | President and CEO | Jan 07, 2021 | Sale | $172.44 | 29,353 | 5,061,681 | 715,209 | Jan 08, 2021, 07:52 PM |
| SIMPSON TODD E | Chief Financial Officer | Dec 18, 2020 | Option Exercise | $26.71 | 34,773 | 928,772 | 152,436 | Dec 18, 2020, 08:51 PM |
| SIMPSON TODD E | Chief Financial Officer | Dec 18, 2020 | Sale | $200.00 | 33,669 | 6,733,800 | 118,767 | Dec 18, 2020, 08:51 PM |
| LIU JEAN I | GC/EVP, Leg Affairs | Dec 14, 2020 | Option Exercise | $35.95 | 5,000 | 179,750 | 63,642 | Dec 16, 2020, 07:41 PM |
| LIU JEAN I | GC/EVP, Leg Affairs | Dec 16, 2020 | Option Exercise | $35.95 | 1,624 | 58,383 | 60,266 | Dec 16, 2020, 07:41 PM |
| LIU JEAN I | GC/EVP, Leg Affairs | Dec 14, 2020 | Sale | $195.86 | 5,000 | 979,316 | 62,001 | Dec 16, 2020, 07:41 PM |
| HIMES VAUGHN B | Chief Technical Officer | Dec 07, 2020 | Option Exercise | $25.36 | 12,761 | 323,646 | 199,590 | Dec 09, 2020, 08:08 PM |
| HIMES VAUGHN B | Chief Technical Officer | Dec 07, 2020 | Sale | $181.76 | 8,000 | 1,454,041 | 198,036 | Dec 09, 2020, 08:08 PM |
| SIEGALL CLAY B | President and CEO | Dec 04, 2020 | Option Exercise | $15.46 | 21,732 | 335,977 | 730,117 | Dec 08, 2020, 07:33 PM |
| SIEGALL CLAY B | President and CEO | Dec 07, 2020 | Option Exercise | $15.46 | 15,723 | 243,078 | 720,265 | Dec 08, 2020, 07:33 PM |
| SIEGALL CLAY B | President and CEO | Dec 07, 2020 | Sale | $181.14 | 15,723 | 2,848,122 | 715,209 | Dec 08, 2020, 07:33 PM |
| SIEGALL CLAY B | President and CEO | Dec 04, 2020 | Sale | $179.43 | 21,732 | 3,899,386 | 715,209 | Dec 08, 2020, 07:33 PM |
| SIEGALL CLAY B | President and CEO | Dec 03, 2020 | Option Exercise | $15.46 | 21,253 | 328,571 | 726,145 | Dec 04, 2020, 07:18 PM |
| SIEGALL CLAY B | President and CEO | Dec 03, 2020 | Sale | $179.28 | 21,253 | 3,810,144 | 715,209 | Dec 04, 2020, 07:18 PM |
| ROMP CHARLES R | EVP, Commercial | Dec 03, 2020 | Option Exercise | $39.15 | 7,666 | 300,124 | 51,743 | Dec 03, 2020, 05:45 PM |
| ROMP CHARLES R | EVP, Commercial | Dec 01, 2020 | Option Exercise | $39.15 | 6,000 | 234,900 | 50,077 | Dec 03, 2020, 05:45 PM |
| ROMP CHARLES R | EVP, Commercial | Dec 03, 2020 | Sale | $179.30 | 7,666 | 1,374,514 | 44,077 | Dec 03, 2020, 05:45 PM |
| ROMP CHARLES R | EVP, Commercial | Dec 01, 2020 | Sale | $179.09 | 6,000 | 1,074,540 | 44,077 | Dec 03, 2020, 05:45 PM |
| GRYSKA DAVID W | Director | Nov 19, 2020 | Option Exercise | $19.02 | 15,000 | 285,300 | 52,719 | Nov 23, 2020, 08:11 PM |
| GRYSKA DAVID W | Director | Nov 19, 2020 | Sale | $173.70 | 15,000 | 2,605,523 | 44,848 | Nov 23, 2020, 08:11 PM |
| SIMPSON TODD E | Chief Financial Officer | Nov 05, 2020 | Sale | $180.37 | 7,509 | 1,354,383 | 118,767 | Nov 09, 2020, 07:25 PM |
| GRYSKA DAVID W | Director | Nov 05, 2020 | Sale | $180.60 | 4,500 | 812,700 | 44,848 | Nov 06, 2020, 07:53 PM |
| ROMP CHARLES R | EVP, Commercial | Nov 04, 2020 | Option Exercise | $41.74 | 14,079 | 587,703 | 49,228 | Nov 06, 2020, 07:34 PM |
| ROMP CHARLES R | EVP, Commercial | Nov 04, 2020 | Sale | $180.37 | 14,079 | 2,539,420 | 44,077 | Nov 06, 2020, 07:34 PM |
| DANSEY ROGER D | Chief Medical Officer | Nov 04, 2020 | Sale | $177.00 | 7,661 | 1,356,020 | 110,580 | Nov 05, 2020, 09:38 PM |
| LIPPMAN MARC E | Director | Nov 03, 2020 | Option Exercise | $35.47 | 62,780 | 2,226,870 | 144,432 | Nov 05, 2020, 08:44 PM |
| LIPPMAN MARC E | Director | Nov 03, 2020 | Sale | $168.61 | 142,090 | 23,958,287 | 131,648 | Nov 05, 2020, 08:44 PM |
| WELCH DANIEL G | Director | Nov 02, 2020 | Option Exercise | $25.21 | 49,500 | 1,247,653 | 71,098 | Nov 04, 2020, 08:51 PM |
| WELCH DANIEL G | Director | Nov 02, 2020 | Sale | $166.13 | 58,750 | 9,760,260 | 56,598 | Nov 04, 2020, 08:51 PM |
| ROMP CHARLES R | EVP, Commercial | Nov 03, 2020 | Option Exercise | $19.24 | 5,197 | 99,979 | 47,719 | Nov 04, 2020, 08:23 PM |
| ROMP CHARLES R | EVP, Commercial | Nov 02, 2020 | Sale | $166.77 | 13,001 | 2,168,133 | 52,409 | Nov 04, 2020, 08:23 PM |
| ROMP CHARLES R | EVP, Commercial | Nov 03, 2020 | Sale | $172.07 | 6,061 | 1,042,939 | 44,941 | Nov 04, 2020, 08:23 PM |
| LIU JEAN I | GC/EVP, Leg Affairs | Sep 21, 2020 | Option Exercise | $36.77 | 9,954 | 366,019 | 58,642 | Sep 23, 2020, 07:28 PM |
| LIU JEAN I | GC/EVP, Leg Affairs | Sep 14, 2020 | Sale | $170.00 | 11,610 | 1,973,700 | 48,688 | Sep 16, 2020, 06:53 PM |
| HIMES VAUGHN B | Chief Technical Officer | Sep 09, 2020 | Option Exercise | $15.46 | 8,000 | 123,680 | 194,829 | Sep 11, 2020, 06:25 PM |
| HIMES VAUGHN B | Chief Technical Officer | Sep 09, 2020 | Sale | $147.55 | 8,000 | 1,180,385 | 192,329 | Sep 11, 2020, 06:25 PM |
| DANSEY ROGER D | Chief Medical Officer | Aug 31, 2020 | Sale | $155.69 | 4,611 | 717,905 | 118,792 | Sep 02, 2020, 07:25 PM |
| HIMES VAUGHN B | Chief Technical Officer | Aug 31, 2020 | Sale | $155.69 | 3,585 | 558,163 | 188,625 | Sep 02, 2020, 07:25 PM |
| LIU JEAN I | GC/EVP, Leg Affairs | Aug 31, 2020 | Sale | $155.69 | 3,648 | 567,972 | 62,191 | Sep 02, 2020, 07:25 PM |
| ROMP CHARLES R | EVP, Commercial | Aug 31, 2020 | Sale | $155.69 | 1,133 | 176,401 | 58,497 | Sep 02, 2020, 07:25 PM |
| SIMPSON TODD E | Chief Financial Officer | Sep 01, 2020 | Sale | $155.86 | 12,091 | 1,884,512 | 133,915 | Sep 02, 2020, 07:24 PM |
| SIMPSON TODD E | Chief Financial Officer | Aug 31, 2020 | Sale | $155.69 | 4,187 | 651,891 | 140,489 | Sep 02, 2020, 07:24 PM |
| SIEGALL CLAY B | President and CEO | Aug 31, 2020 | Sale | $155.69 | 14,351 | 2,234,365 | 719,996 | Sep 02, 2020, 07:24 PM |
| SIEGALL CLAY B | President and CEO | Aug 21, 2020 | Option Exercise | $19.42 | 10,299 | 199,984 | 729,560 | Aug 25, 2020, 06:35 PM |
| LIU JEAN I | GC/EVP, Leg Affairs | Aug 18, 2020 | Sale | $158.17 | 6,846 | 1,082,825 | 63,946 | Aug 20, 2020, 06:58 PM |
| SIMPSON TODD E | Chief Financial Officer | Aug 18, 2020 | Sale | $158.17 | 9,262 | 1,464,961 | 142,554 | Aug 20, 2020, 06:27 PM |
| SIEGALL CLAY B | President and CEO | Aug 18, 2020 | Sale | $158.17 | 27,060 | 4,280,053 | 719,261 | Aug 20, 2020, 06:26 PM |
| ROMP CHARLES R | EVP, Commercial | Aug 18, 2020 | Sale | $158.17 | 4,027 | 636,943 | 59,075 | Aug 20, 2020, 06:26 PM |
| HIMES VAUGHN B | Chief Technical Officer | Aug 18, 2020 | Sale | $158.17 | 8,054 | 1,273,893 | 190,414 | Aug 20, 2020, 06:23 PM |
| DANSEY ROGER D | Chief Medical Officer | Aug 17, 2020 | Sale | $157.79 | 450 | 71,006 | 122,493 | Aug 17, 2020, 09:40 PM |
| SIEGALL CLAY B | President and CEO | Aug 10, 2020 | Option Exercise | $12.00 | 28,475 | 341,700 | 729,955 | Aug 13, 2020, 06:04 AM |
| SIEGALL CLAY B | President and CEO | Aug 10, 2020 | Sale | $156.74 | 28,475 | 4,463,263 | 718,339 | Aug 13, 2020, 06:04 AM |
| SIMPSON TODD E | Chief Financial Officer | Aug 03, 2020 | Sale | $165.72 | 20,000 | 3,314,419 | 155,461 | Aug 05, 2020, 07:14 PM |
| HIMES VAUGHN B | Chief Technical Officer | Jul 17, 2020 | Option Exercise | $15.46 | 8,000 | 123,680 | 199,840 | Jul 21, 2020, 07:48 PM |
| HIMES VAUGHN B | Chief Technical Officer | Jul 17, 2020 | Sale | $179.42 | 8,000 | 1,435,363 | 198,640 | Jul 21, 2020, 07:48 PM |
| SIEGALL CLAY B | President and CEO | Jul 08, 2020 | Option Exercise | $12.00 | 28,472 | 341,664 | 734,660 | Jul 10, 2020, 06:07 PM |
| SIEGALL CLAY B | President and CEO | Jul 08, 2020 | Sale | $175.08 | 28,472 | 4,984,808 | 718,339 | Jul 10, 2020, 06:07 PM |
| ROMP CHARLES R | EVP, Commercial | Jul 02, 2020 | Sale | $167.49 | 712 | 119,253 | 55,307 | Jul 07, 2020, 06:34 PM |
| SIMPSON TODD E | Chief Financial Officer | Jul 01, 2020 | Sale | $167.58 | 11,573 | 1,939,352 | 173,454 | Jul 02, 2020, 07:19 PM |
| LIU JEAN I | GC/EVP, Leg Affairs | Jun 19, 2020 | Sale | $165.00 | 9,877 | 1,629,705 | 63,597 | Jun 22, 2020, 07:46 PM |
| DANSEY ROGER D | Chief Medical Officer | Jun 17, 2020 | Sale | $158.89 | 2,162 | 343,523 | 110,870 | Jun 19, 2020, 05:54 PM |
| DANSEY ROGER D | Chief Medical Officer | Jun 16, 2020 | Sale | $157.15 | 838 | 131,692 | 111,770 | Jun 17, 2020, 07:24 PM |
| DANSEY ROGER D | Chief Medical Officer | Jun 15, 2020 | Sale | $157.15 | 4,984 | 783,236 | 112,608 | Jun 17, 2020, 07:24 PM |
| SIEGALL CLAY B | President and CEO | Jun 08, 2020 | Option Exercise | $12.00 | 28,472 | 341,664 | 724,939 | Jun 10, 2020, 06:57 PM |
| SIEGALL CLAY B | President and CEO | Jun 08, 2020 | Sale | $148.77 | 28,472 | 4,235,807 | 718,339 | Jun 10, 2020, 06:57 PM |
| BAKER BROS. ADVISORS LP | Director | May 15, 2020 | Sale | $160.00 | 1,750,000 | 280,000,000 | 43,288,836 | May 19, 2020, 06:03 PM |
| ROMP CHARLES R | EVP, Commercial | May 12, 2020 | Option Exercise | $15.46 | 6,942 | 107,323 | 59,517 | May 14, 2020, 06:54 PM |
| ROMP CHARLES R | EVP, Commercial | May 12, 2020 | Sale | $166.00 | 6,942 | 1,152,372 | 52,575 | May 14, 2020, 06:54 PM |
| SIEGALL CLAY B | President and CEO | May 08, 2020 | Option Exercise | $12.00 | 28,472 | 341,664 | 728,603 | May 12, 2020, 07:51 PM |
| SIEGALL CLAY B | President and CEO | May 08, 2020 | Sale | $161.01 | 28,472 | 4,584,311 | 718,339 | May 12, 2020, 07:51 PM |
| ROMP CHARLES R | EVP, Commercial | May 08, 2020 | Option Exercise | $15.46 | 6,942 | 107,323 | 59,517 | May 08, 2020, 07:54 PM |
| ROMP CHARLES R | EVP, Commercial | May 08, 2020 | Sale | $163.02 | 6,942 | 1,131,671 | 52,575 | May 08, 2020, 07:54 PM |
| DANSEY ROGER D | Chief Medical Officer | May 07, 2020 | Option Exercise | $65.11 | 11,912 | 775,590 | 129,145 | May 08, 2020, 07:42 PM |
| DANSEY ROGER D | Chief Medical Officer | May 07, 2020 | Sale | $164.50 | 11,912 | 1,959,524 | 117,233 | May 08, 2020, 07:42 PM |
| BAKER BROS. ADVISORS LP | Director | May 06, 2020 | Sale | $165.04 | 390,072 | 64,379,426 | 45,814,543 | May 08, 2020, 05:47 PM |
| BAKER BROS. ADVISORS LP | Director | May 08, 2020 | Sale | $158.50 | 500,000 | 79,250,000 | 44,891,148 | May 08, 2020, 05:47 PM |
| BAKER BROS. ADVISORS LP | Director | May 07, 2020 | Sale | $164.41 | 168,244 | 27,660,924 | 45,486,837 | May 08, 2020, 05:47 PM |
| WELCH DANIEL G | Director | May 05, 2020 | Sale | $166.73 | 20,000 | 3,334,641 | 86,958 | May 07, 2020, 07:59 PM |
| WELCH DANIEL G | Director | May 06, 2020 | Sale | $164.79 | 15,000 | 2,471,919 | 62,222 | May 07, 2020, 07:59 PM |
| SIEGALL CLAY B | President and CEO | May 06, 2020 | Sale | $165.23 | 25,402 | 4,197,062 | 739,795 | May 07, 2020, 07:59 PM |
| SIEGALL CLAY B | President and CEO | May 05, 2020 | Sale | $166.08 | 24,598 | 4,085,341 | 761,170 | May 07, 2020, 07:59 PM |
| ROMP CHARLES R | EVP, Commercial | May 05, 2020 | Sale | $166.18 | 5,056 | 840,225 | 54,575 | May 07, 2020, 07:59 PM |
| AKKARAJU SRINIVAS | Director | May 05, 2020 | Option Exercise | $20.06 | 8,500 | 170,510 | 48,668 | May 07, 2020, 07:58 PM |
| AKKARAJU SRINIVAS | Director | May 05, 2020 | Sale | $167.26 | 8,500 | 1,421,710 | 40,168 | May 07, 2020, 07:58 PM |
| SIMPSON TODD E | Chief Financial Officer | May 05, 2020 | Option Exercise | $22.15 | 39,059 | 865,277 | 188,563 | May 06, 2020, 06:32 PM |
| SIMPSON TODD E | Chief Financial Officer | May 04, 2020 | Option Exercise | $12.00 | 14,167 | 170,004 | 175,863 | May 06, 2020, 06:32 PM |
| SIMPSON TODD E | Chief Financial Officer | May 05, 2020 | Sale | $162.94 | 26,867 | 4,377,596 | 175,063 | May 06, 2020, 06:32 PM |
| SIMPSON TODD E | Chief Financial Officer | May 04, 2020 | Sale | $147.00 | 14,167 | 2,082,563 | 161,696 | May 06, 2020, 06:32 PM |
| LIPPMAN MARC E | Director | May 04, 2020 | Sale | $152.03 | 1,000 | 152,030 | 130,313 | May 06, 2020, 06:19 PM |
| BAKER BROS. ADVISORS LP | Director | Apr 23, 2020 | Option Exercise | $12.76 | 35,000 | 446,600 | 45,860,149 | Apr 24, 2020, 04:25 PM |
| ROMP CHARLES R | EVP, Commercial | Apr 19, 2020 | Option Exercise | $139.91 | 326 | 45,612 | 56,809 | Apr 22, 2020, 06:12 AM |
| LIU JEAN I | GC/EVP, Leg Afairs | Apr 19, 2020 | Option Exercise | $139.92 | 645 | 90,246 | 73,474 | Apr 22, 2020, 06:11 AM |
| HIMES VAUGHN B | Chief Technical Officer | Apr 21, 2020 | Option Exercise | $139.92 | 920 | 128,724 | 191,582 | Apr 21, 2020, 09:59 PM |
| DANSEY ROGER D | Chief Medical Officer | Apr 21, 2020 | Option Exercise | $139.92 | 1,159 | 162,164 | 117,233 | Apr 21, 2020, 09:58 PM |
| SIEGALL CLAY B | President and CEO | Apr 21, 2020 | Option Exercise | $139.92 | 3,023 | 422,969 | 768,339 | Apr 21, 2020, 09:57 PM |
| SIMPSON TODD E | Chief Financial Officer | Apr 21, 2020 | Option Exercise | $139.92 | 570 | 79,752 | 161,696 | Apr 21, 2020, 09:57 PM |
| SIEGALL CLAY B | President and CEO | Apr 08, 2020 | Option Exercise | $12.00 | 28,472 | 341,664 | 779,866 | Apr 10, 2020, 07:31 PM |
| SIEGALL CLAY B | President and CEO | Apr 08, 2020 | Sale | $120.01 | 28,472 | 3,416,814 | 758,784 | Apr 10, 2020, 07:31 PM |
| SIEGALL CLAY B | President and CEO | Mar 09, 2020 | Option Exercise | $12.00 | 28,472 | 341,664 | 768,581 | Mar 11, 2020, 06:51 PM |
| SIEGALL CLAY B | President and CEO | Mar 09, 2020 | Sale | $110.09 | 28,472 | 3,134,578 | 758,784 | Mar 11, 2020, 06:51 PM |
| HIMES VAUGHN B | Chief Technical Officer | Mar 06, 2020 | Option Exercise | $13.51 | 8,000 | 108,117 | 193,172 | Mar 10, 2020, 08:12 PM |
| HIMES VAUGHN B | Chief Technical Officer | Mar 06, 2020 | Sale | $114.91 | 8,000 | 919,292 | 188,874 | Mar 10, 2020, 08:12 PM |
| DANSEY ROGER D | Chief Medical Officer | Feb 18, 2020 | Sale | $116.33 | 350 | 40,716 | 107,659 | Feb 20, 2020, 05:33 PM |
| SIEGALL CLAY B | President and CEO | Feb 10, 2020 | Option Exercise | $12.00 | 28,472 | 341,664 | 768,723 | Feb 12, 2020, 05:38 PM |
| SIEGALL CLAY B | President and CEO | Feb 10, 2020 | Sale | $114.61 | 28,472 | 3,263,110 | 758,784 | Feb 12, 2020, 05:38 PM |
| DANSEY ROGER D | Chief Medical Officer | Feb 03, 2020 | Sale | $108.51 | 727 | 78,887 | 108,009 | Feb 05, 2020, 06:08 PM |
| SIEGALL CLAY B | President and CEO | Jan 08, 2020 | Option Exercise | $12.00 | 28,472 | 341,664 | 785,937 | Jan 10, 2020, 07:08 PM |
| SIEGALL CLAY B | President and CEO | Jan 08, 2020 | Sale | $111.32 | 28,472 | 3,169,433 | 758,784 | Jan 10, 2020, 07:08 PM |
| WELCH DANIEL G | Director | Jan 07, 2020 | Option Exercise | $12.76 | 17,500 | 223,300 | 90,263 | Jan 09, 2020, 08:32 PM |
| DANSEY ROGER D | Chief Medical Officer | Dec 16, 2019 | Sale | $114.07 | 2,000 | 228,140 | 101,146 | Dec 17, 2019, 06:48 PM |
| SIEGALL CLAY B | President and CEO | Dec 09, 2019 | Option Exercise | $12.00 | 28,472 | 341,664 | 773,011 | Dec 10, 2019, 07:15 PM |
| SIEGALL CLAY B | President and CEO | Dec 09, 2019 | Sale | $114.56 | 28,472 | 3,261,641 | 755,684 | Dec 10, 2019, 07:15 PM |
| HIMES VAUGHN B | Chief Technical Officer | Dec 06, 2019 | Option Exercise | $12.00 | 8,000 | 96,000 | 195,518 | Dec 10, 2019, 07:14 PM |
| HIMES VAUGHN B | Chief Technical Officer | Dec 06, 2019 | Sale | $117.16 | 8,000 | 937,265 | 188,567 | Dec 10, 2019, 07:14 PM |
| DANSEY ROGER D | Chief Medical Officer | Nov 25, 2019 | Option Exercise | $65.11 | 5,000 | 325,550 | 108,146 | Nov 27, 2019, 05:32 PM |
| DANSEY ROGER D | Chief Medical Officer | Nov 25, 2019 | Sale | $121.48 | 5,000 | 607,390 | 103,146 | Nov 27, 2019, 05:32 PM |
| AKKARAJU SRINIVAS | Director | Nov 21, 2019 | Option Exercise | $19.02 | 17,500 | 332,850 | 52,726 | Nov 22, 2019, 06:35 PM |
| AKKARAJU SRINIVAS | Director | Nov 21, 2019 | Sale | $119.78 | 17,500 | 2,096,120 | 40,168 | Nov 22, 2019, 06:35 PM |
| DANSEY ROGER D | Chief Medical Officer | Nov 18, 2019 | Option Exercise | $65.11 | 5,000 | 325,550 | 108,146 | Nov 20, 2019, 06:45 PM |
| DANSEY ROGER D | Chief Medical Officer | Nov 18, 2019 | Sale | $116.00 | 5,000 | 580,000 | 103,146 | Nov 20, 2019, 06:45 PM |
| LIPPMAN MARC E | Director | Nov 18, 2019 | Option Exercise | $15.89 | 35,000 | 556,150 | 148,813 | Nov 20, 2019, 06:41 PM |
| LIPPMAN MARC E | Director | Nov 18, 2019 | Sale | $115.80 | 35,000 | 4,053,000 | 131,313 | Nov 20, 2019, 06:41 PM |
| SIEGALL CLAY B | President and CEO | Nov 08, 2019 | Option Exercise | $12.00 | 28,472 | 341,664 | 776,483 | Nov 12, 2019, 06:24 PM |
| SIEGALL CLAY B | President and CEO | Nov 08, 2019 | Sale | $107.61 | 28,472 | 3,063,816 | 755,684 | Nov 12, 2019, 06:24 PM |
| SIEGALL CLAY B | President and CEO | Oct 08, 2019 | Option Exercise | $12.00 | 28,472 | 341,664 | 770,104 | Oct 10, 2019, 06:55 PM |
| SIEGALL CLAY B | President and CEO | Oct 08, 2019 | Sale | $82.47 | 28,472 | 2,348,062 | 755,684 | Oct 10, 2019, 06:55 PM |
| GRYSKA DAVID W | Director | Oct 01, 2019 | Option Exercise | $15.89 | 5,000 | 79,450 | 50,513 | Oct 03, 2019, 07:38 PM |
| GRYSKA DAVID W | Director | Oct 01, 2019 | Sale | $85.09 | 5,000 | 425,450 | 48,013 | Oct 03, 2019, 07:38 PM |
| SIMPSON TODD E | Chief Financial Officer | Sep 30, 2019 | Sale | $85.00 | 15,000 | 1,275,000 | 157,567 | Oct 02, 2019, 06:12 PM |
| LIU JEAN I | GC/EVP, Leg Affairs | Sep 30, 2019 | Sale | $86.00 | 7,432 | 639,152 | 74,404 | Oct 02, 2019, 06:10 PM |
| DANSEY ROGER D | Chief Medical Officer | Sep 25, 2019 | Sale | $73.80 | 3,000 | 221,415 | 103,636 | Sep 27, 2019, 06:12 PM |
| SIEGALL CLAY B | President and CEO | Sep 09, 2019 | Option Exercise | $12.00 | 28,472 | 341,664 | 774,374 | Sep 10, 2019, 07:29 PM |
| SIEGALL CLAY B | President and CEO | Sep 09, 2019 | Sale | $68.33 | 28,472 | 1,945,531 | 755,684 | Sep 10, 2019, 07:29 PM |
| SIEGALL CLAY B | See Remarks | Sep 03, 2019 | Sale | $70.80 | 9,693 | 686,257 | 755,684 | Sep 04, 2019, 09:46 PM |
| HIMES VAUGHN B | See Remarks | Aug 30, 2019 | Option Exercise | $12.00 | 8,000 | 96,000 | 201,210 | Sep 04, 2019, 09:45 PM |
| HIMES VAUGHN B | See Remarks | Sep 03, 2019 | Sale | $70.80 | 5,692 | 402,990 | 191,396 | Sep 04, 2019, 09:45 PM |
| HIMES VAUGHN B | See Remarks | Aug 30, 2019 | Sale | $72.86 | 8,000 | 582,859 | 193,923 | Sep 04, 2019, 09:45 PM |
| DANSEY ROGER D | See Remarks | Sep 03, 2019 | Sale | $70.80 | 922 | 65,277 | 106,317 | Sep 04, 2019, 09:43 PM |
| SIMPSON TODD E | See Remarks | Sep 03, 2019 | Sale | $70.80 | 2,092 | 148,112 | 172,567 | Sep 04, 2019, 09:42 PM |
| SIMPSON TODD E | Chief Financial Officer | Aug 28, 2019 | Sale | $73.21 | 5,909 | 432,624 | 153,371 | Aug 30, 2019, 04:36 PM |
| SIEGALL CLAY B | President and CEO | Aug 28, 2019 | Sale | $73.21 | 28,951 | 2,119,636 | 717,343 | Aug 30, 2019, 04:35 PM |
| LIU JEAN I | GC/EVP, Leg Affairs | Aug 28, 2019 | Sale | $73.21 | 6,013 | 440,242 | 60,904 | Aug 30, 2019, 04:35 PM |
| HIMES VAUGHN B | Chief Technical Officer | Aug 28, 2019 | Sale | $73.21 | 6,836 | 500,496 | 175,197 | Aug 30, 2019, 04:35 PM |
| SIMPSON TODD E | Chief Financial Officer | Aug 20, 2019 | Sale | $80.00 | 12,500 | 1,000,000 | 159,280 | Aug 22, 2019, 05:49 PM |
| LIU JEAN I | GC/EVP, Leg Affairs | Aug 20, 2019 | Sale | $80.00 | 3,716 | 297,280 | 66,917 | Aug 22, 2019, 05:47 PM |
| SIEGALL CLAY B | President and CEO | Aug 08, 2019 | Option Exercise | $12.16 | 20,149 | 245,012 | 756,192 | Aug 09, 2019, 05:06 PM |
| SIEGALL CLAY B | President and CEO | Aug 08, 2019 | Sale | $76.52 | 20,149 | 1,541,827 | 746,294 | Aug 09, 2019, 05:06 PM |
| LIU JEAN I | GC/EVP, Leg Affairs | Aug 06, 2019 | Sale | $75.00 | 3,716 | 278,700 | 70,633 | Aug 08, 2019, 05:42 PM |
| GRYSKA DAVID W | Director | Jul 17, 2019 | Option Exercise | $12.76 | 5,000 | 63,800 | 53,013 | Jul 19, 2019, 06:20 PM |
| GRYSKA DAVID W | Director | Jul 17, 2019 | Sale | $75.00 | 5,000 | 375,000 | 48,013 | Jul 19, 2019, 06:20 PM |
| SIEGALL CLAY B | President and CEO | Jul 08, 2019 | Option Exercise | $12.16 | 20,148 | 245,000 | 761,011 | Jul 10, 2019, 06:57 PM |
| SIEGALL CLAY B | President and CEO | Jul 08, 2019 | Sale | $66.89 | 20,148 | 1,347,664 | 746,294 | Jul 10, 2019, 06:57 PM |
| HIMES VAUGHN B | Chief Technical Officer | Jun 24, 2019 | Option Exercise | $42.51 | 4,704 | 199,970 | 182,033 | Jun 26, 2019, 06:26 PM |
| DANSEY ROGER D | Chief Medical Officer | Jun 17, 2019 | Sale | $68.60 | 5,416 | 371,538 | 77,593 | Jun 19, 2019, 06:43 PM |
| SIEGALL CLAY B | President and CEO | Jun 10, 2019 | Option Exercise | $12.16 | 20,148 | 245,000 | 760,119 | Jun 12, 2019, 05:51 PM |
| SIEGALL CLAY B | President and CEO | Jun 10, 2019 | Sale | $69.05 | 20,148 | 1,391,175 | 749,169 | Jun 12, 2019, 05:51 PM |
| HIMES VAUGHN B | Chief Technical Officer | May 31, 2019 | Option Exercise | $12.00 | 8,000 | 96,000 | 185,329 | Jun 04, 2019, 06:28 PM |
| HIMES VAUGHN B | Chief Technical Officer | May 31, 2019 | Sale | $65.94 | 8,000 | 527,485 | 179,889 | Jun 04, 2019, 06:28 PM |
| SIEGALL CLAY B | President and CEO | May 08, 2019 | Option Exercise | $12.16 | 15,324 | 186,340 | 762,600 | May 10, 2019, 04:39 PM |
| SIEGALL CLAY B | President and CEO | May 09, 2019 | Option Exercise | $12.16 | 4,824 | 58,660 | 752,063 | May 10, 2019, 04:39 PM |
| SIEGALL CLAY B | President and CEO | May 08, 2019 | Sale | $68.26 | 15,324 | 1,046,066 | 749,169 | May 10, 2019, 04:39 PM |
| SIEGALL CLAY B | President and CEO | May 09, 2019 | Sale | $67.43 | 4,824 | 325,301 | 749,169 | May 10, 2019, 04:39 PM |
| BAKER BROS. ADVISORS LP | Director | Apr 29, 2019 | Option Exercise | $8.38 | 20,000 | 167,600 | 45,839,686 | May 01, 2019, 04:59 PM |
| SIEGALL CLAY B | President and CEO | Apr 08, 2019 | Option Exercise | $12.16 | 20,148 | 245,000 | 757,976 | Apr 10, 2019, 04:39 PM |
| SIEGALL CLAY B | President and CEO | Apr 08, 2019 | Sale | $79.22 | 20,148 | 1,596,100 | 749,169 | Apr 10, 2019, 04:39 PM |
| SIMPSON TODD E | Chief Financial Officer | Apr 05, 2019 | Sale | $78.00 | 12,500 | 975,000 | 182,217 | Apr 09, 2019, 08:35 PM |
| GRYSKA DAVID W | Director | Apr 01, 2019 | Option Exercise | $12.76 | 5,000 | 63,800 | 50,050 | Apr 03, 2019, 08:57 PM |
| GRYSKA DAVID W | Director | Apr 01, 2019 | Sale | $73.41 | 5,000 | 367,030 | 45,256 | Apr 03, 2019, 08:57 PM |
| SIEGALL CLAY B | President and CEO | Mar 18, 2019 | Option Exercise | $12.08 | 16,556 | 199,988 | 749,169 | Mar 20, 2019, 06:34 PM |
| SIEGALL CLAY B | President and CEO | Mar 08, 2019 | Option Exercise | $12.16 | 20,148 | 245,000 | 745,259 | Mar 12, 2019, 07:34 PM |
| SIEGALL CLAY B | President and CEO | Mar 08, 2019 | Sale | $69.19 | 20,148 | 1,394,094 | 732,613 | Mar 12, 2019, 07:34 PM |
| HIMES VAUGHN B | Chief Technical Officer | Mar 08, 2019 | Option Exercise | $12.00 | 8,000 | 96,000 | 185,329 | Mar 12, 2019, 07:31 PM |
| HIMES VAUGHN B | Chief Technical Officer | Mar 08, 2019 | Sale | $68.72 | 8,000 | 549,746 | 180,672 | Mar 12, 2019, 07:31 PM |
| SIMPSON TODD E | Chief Financial Officer | Mar 04, 2019 | Sale | $75.00 | 10,000 | 750,000 | 184,280 | Mar 06, 2019, 06:58 PM |
| SIEGALL CLAY B | See Remarks | Feb 08, 2019 | Option Exercise | $12.16 | 20,148 | 245,000 | 740,690 | Feb 12, 2019, 06:25 PM |
| SIEGALL CLAY B | See Remarks | Feb 08, 2019 | Sale | $65.17 | 20,148 | 1,313,126 | 732,613 | Feb 12, 2019, 06:25 PM |
| GRYSKA DAVID W | Director | Jan 08, 2019 | Option Exercise | $12.76 | 5,000 | 63,800 | 50,050 | Jan 10, 2019, 09:09 PM |
| GRYSKA DAVID W | Director | Jan 08, 2019 | Sale | $65.04 | 5,000 | 325,200 | 45,050 | Jan 10, 2019, 09:09 PM |
| SIEGALL CLAY B | President and CEO | Jan 08, 2019 | Option Exercise | $12.16 | 20,148 | 245,000 | 739,713 | Jan 10, 2019, 08:27 PM |
| SIEGALL CLAY B | President and CEO | Jan 08, 2019 | Sale | $65.73 | 20,148 | 1,324,237 | 732,613 | Jan 10, 2019, 08:27 PM |
| SIEGALL CLAY B | President and CEO | Dec 10, 2018 | Option Exercise | $12.16 | 20,148 | 245,000 | 745,761 | Dec 12, 2018, 07:31 PM |
| SIEGALL CLAY B | President and CEO | Dec 10, 2018 | Sale | $59.74 | 20,148 | 1,203,545 | 732,613 | Dec 12, 2018, 07:31 PM |
| HIMES VAUGHN B | Chief Technical Officer | Nov 30, 2018 | Option Exercise | $12.00 | 5,000 | 60,000 | 177,329 | Dec 04, 2018, 07:37 PM |
| HIMES VAUGHN B | Chief Technical Officer | Nov 30, 2018 | Sale | $62.14 | 5,000 | 310,718 | 172,729 | Dec 04, 2018, 07:37 PM |
| Cline Darren S | EVP, Commercial | Nov 29, 2018 | Sale | $62.88 | 7,000 | 440,160 | 72,556 | Nov 30, 2018, 06:32 PM |
| Cline Darren S | EVP, Commercial | Nov 21, 2018 | Sale | $56.68 | 4,167 | 236,204 | 79,556 | Nov 21, 2018, 06:42 PM |
| SIEGALL CLAY B | President and CEO | Nov 08, 2018 | Option Exercise | $12.16 | 20,148 | 245,000 | 746,091 | Nov 09, 2018, 05:54 PM |
| SIEGALL CLAY B | President and CEO | Nov 08, 2018 | Sale | $61.54 | 20,148 | 1,239,873 | 732,613 | Nov 09, 2018, 05:54 PM |
| AKKARAJU SRINIVAS | Director | Oct 30, 2018 | Option Exercise | $8.38 | 5,000 | 41,900 | 37,205 | Nov 01, 2018, 05:55 PM |
| SIEGALL CLAY B | President and CEO | Oct 08, 2018 | Option Exercise | $12.16 | 20,148 | 245,000 | 746,550 | Oct 09, 2018, 08:13 PM |
| SIEGALL CLAY B | President and CEO | Oct 08, 2018 | Sale | $77.39 | 20,148 | 1,559,231 | 732,613 | Oct 09, 2018, 08:13 PM |
| SIEGALL CLAY B | President and CEO | Sep 17, 2018 | Option Exercise | $12.16 | 20,148 | 245,000 | 742,544 | Sep 19, 2018, 06:36 PM |
| SIEGALL CLAY B | President and CEO | Sep 17, 2018 | Sale | $76.84 | 20,148 | 1,548,196 | 732,613 | Sep 19, 2018, 06:36 PM |
| HIMES VAUGHN B | Chief Technical Officer | Sep 07, 2018 | Option Exercise | $12.00 | 5,000 | 60,000 | 182,329 | Sep 11, 2018, 07:26 PM |
| HIMES VAUGHN B | Chief Technical Officer | Sep 07, 2018 | Sale | $76.99 | 5,000 | 384,962 | 180,929 | Sep 11, 2018, 07:26 PM |
| SIMPSON TODD E | Chief Financial Officer | Aug 27, 2018 | Sale | $74.23 | 5,427 | 402,856 | 173,565 | Aug 29, 2018, 07:40 PM |
| SIEGALL CLAY B | President and CEO | Aug 27, 2018 | Sale | $74.23 | 25,514 | 1,893,950 | 636,632 | Aug 29, 2018, 07:39 PM |
| LIU JEAN I | GC/EVP, Leg Affairs | Aug 27, 2018 | Sale | $74.23 | 4,123 | 306,058 | 56,741 | Aug 29, 2018, 07:37 PM |
| HIMES VAUGHN B | Chief Technical Officer | Aug 27, 2018 | Sale | $74.23 | 5,530 | 410,502 | 159,376 | Aug 29, 2018, 07:35 PM |
| Cline Darren S | EVP, Commercial | Aug 27, 2018 | Sale | $74.23 | 4,784 | 355,125 | 65,079 | Aug 29, 2018, 07:32 PM |
| SIEGALL CLAY B | President and CEO | Aug 21, 2018 | Sale | $74.95 | 25,000 | 1,873,750 | 662,146 | Aug 23, 2018, 08:01 PM |
| SIEGALL CLAY B | See Remarks | Aug 09, 2018 | Option Exercise | $11.09 | 18,831 | 208,836 | 703,857 | Aug 13, 2018, 04:47 PM |
| SIEGALL CLAY B | See Remarks | Aug 09, 2018 | Sale | $72.71 | 18,831 | 1,369,153 | 687,146 | Aug 13, 2018, 04:47 PM |
| LIPPMAN MARC E | Director | Jul 31, 2018 | Sale | $69.25 | 7,400 | 512,450 | 128,350 | Aug 02, 2018, 08:00 PM |
| SIEGALL CLAY B | President and CEO | Jul 09, 2018 | Option Exercise | $11.09 | 18,832 | 208,847 | 702,356 | Jul 11, 2018, 08:28 PM |
| SIEGALL CLAY B | President and CEO | Jul 09, 2018 | Sale | $69.07 | 18,832 | 1,300,770 | 687,146 | Jul 11, 2018, 08:28 PM |
| Cline Darren S | EVP, Commercial | Jun 12, 2018 | Option Exercise | $29.14 | 10,086 | 293,910 | 79,831 | Jun 14, 2018, 06:31 PM |
| Cline Darren S | EVP, Commercial | Jun 12, 2018 | Sale | $69.00 | 12,054 | 831,688 | 71,831 | Jun 14, 2018, 06:31 PM |
| SIEGALL CLAY B | President and CEO | Jun 08, 2018 | Option Exercise | $11.09 | 18,832 | 208,847 | 705,278 | Jun 12, 2018, 07:34 PM |
| SIEGALL CLAY B | President and CEO | Jun 08, 2018 | Sale | $65.12 | 18,832 | 1,226,341 | 687,146 | Jun 12, 2018, 07:34 PM |
| HIMES VAUGHN B | Chief Technical Officer | May 31, 2018 | Option Exercise | $12.00 | 5,000 | 60,000 | 169,906 | Jun 04, 2018, 07:11 PM |
| HIMES VAUGHN B | Chief Technical Officer | May 31, 2018 | Sale | $58.47 | 5,000 | 292,365 | 168,906 | Jun 04, 2018, 07:11 PM |
| BAKER BROS. ADVISORS LP | Director | May 18, 2018 | Option Exercise | $56.77 | 7,400 | 420,098 | 45,829,686 | May 18, 2018, 04:25 PM |
| SIEGALL CLAY B | President and CEO | May 09, 2018 | Option Exercise | $11.09 | 18,832 | 208,847 | 694,922 | May 11, 2018, 08:01 PM |
| SIEGALL CLAY B | President and CEO | May 09, 2018 | Sale | $54.97 | 18,832 | 1,035,114 | 687,146 | May 11, 2018, 08:01 PM |
| Cline Darren S | EVP, Commercial | May 09, 2018 | Option Exercise | $16.20 | 9,000 | 145,790 | 80,831 | May 11, 2018, 07:59 PM |
| Cline Darren S | EVP, Commercial | May 09, 2018 | Sale | $55.33 | 9,000 | 497,983 | 71,831 | May 11, 2018, 07:59 PM |
| BAKER BROS. ADVISORS LP | Director | May 04, 2018 | Buy | $52.68 | 204,537 | 10,775,582 | 45,569,872 | May 08, 2018, 05:17 PM |
| BAKER BROS. ADVISORS LP | Director | May 08, 2018 | Buy | $54.02 | 126,399 | 6,828,339 | 45,825,986 | May 08, 2018, 05:17 PM |
| BAKER BROS. ADVISORS LP | Director | May 07, 2018 | Buy | $53.70 | 129,715 | 6,966,305 | 45,699,587 | May 08, 2018, 05:17 PM |
| Cline Darren S | EVP, Commercial | May 03, 2018 | Sale | $53.81 | 4,000 | 215,238 | 71,831 | May 07, 2018, 07:08 PM |
| BAKER BROS. ADVISORS LP | Director | May 01, 2018 | Option Exercise | $10.08 | 20,000 | 201,600 | 44,988,471 | May 02, 2018, 06:05 PM |
| BAKER BROS. ADVISORS LP | Director | May 02, 2018 | Buy | $52.57 | 69,947 | 3,676,836 | 45,365,335 | May 02, 2018, 06:05 PM |
| BAKER BROS. ADVISORS LP | Director | May 01, 2018 | Buy | $51.36 | 306,917 | 15,764,736 | 45,295,388 | May 02, 2018, 06:05 PM |
| BAKER BROS. ADVISORS LP | Director | Apr 30, 2018 | Buy | $51.06 | 623,136 | 31,816,925 | 44,978,471 | May 02, 2018, 06:05 PM |
| SIEGALL CLAY B | President and CEO | Apr 09, 2018 | Option Exercise | $11.09 | 18,832 | 208,847 | 705,978 | Apr 11, 2018, 08:38 PM |
| SIEGALL CLAY B | President and CEO | Apr 09, 2018 | Sale | $50.52 | 18,832 | 951,393 | 687,146 | Apr 11, 2018, 08:38 PM |
| DRACHMAN JONATHAN G | CMO & EVP, R & D | Mar 20, 2018 | Option Exercise | $14.15 | 31,039 | 439,134 | 201,973 | Mar 22, 2018, 07:04 PM |
| HIMES VAUGHN B | See Remarks | Mar 15, 2018 | Option Exercise | $12.00 | 5,000 | 60,000 | 169,906 | Mar 19, 2018, 07:35 PM |
| HIMES VAUGHN B | See Remarks | Mar 15, 2018 | Sale | $58.12 | 5,000 | 290,604 | 165,106 | Mar 19, 2018, 07:35 PM |
| SIEGALL CLAY B | President and CEO | Mar 09, 2018 | Option Exercise | $11.09 | 18,832 | 208,847 | 701,214 | Mar 13, 2018, 08:43 PM |
| SIEGALL CLAY B | President and CEO | Mar 09, 2018 | Sale | $57.32 | 18,832 | 1,079,436 | 687,146 | Mar 13, 2018, 08:43 PM |
| DRACHMAN JONATHAN G | CMO & EVP, R & D | Mar 05, 2018 | Option Exercise | $8.96 | 10,457 | 93,695 | 178,134 | Mar 07, 2018, 08:25 PM |
| DRACHMAN JONATHAN G | CMO & EVP, R & D | Mar 05, 2018 | Sale | $52.83 | 10,457 | 552,452 | 170,934 | Mar 07, 2018, 08:25 PM |
| WELCH DANIEL G | Director | Feb 13, 2018 | Option Exercise | $9.39 | 16,881 | 158,463 | 66,100 | Feb 15, 2018, 09:21 PM |
| SIEGALL CLAY B | President and CEO | Feb 09, 2018 | Option Exercise | $11.09 | 18,832 | 208,847 | 697,546 | Feb 13, 2018, 08:19 PM |
| SIEGALL CLAY B | President and CEO | Feb 09, 2018 | Sale | $49.75 | 18,832 | 936,818 | 687,146 | Feb 13, 2018, 08:19 PM |
| Cline Darren S | EVP, Commercial | Feb 05, 2018 | Option Exercise | $55.58 | 1,399 | 77,756 | 75,831 | Feb 07, 2018, 08:17 PM |
| BAKER BROS. ADVISORS LP | Director | Feb 01, 2018 | Buy | $52.00 | 3,456,543 | 179,740,236 | 44,355,335 | Feb 05, 2018, 04:00 PM |
| BAKER BROS. ADVISORS LP | Director | Feb 01, 2018 | Buy | $52.00 | 389,610 | 20,259,720 | 5,278,174 | Feb 05, 2018, 04:00 PM |
| SIEGALL CLAY B | President and CEO | Jan 11, 2018 | Option Exercise | $11.09 | 18,832 | 208,847 | 697,716 | Jan 16, 2018, 08:08 PM |
| SIEGALL CLAY B | President and CEO | Jan 11, 2018 | Sale | $51.71 | 18,832 | 973,873 | 687,146 | Jan 16, 2018, 08:08 PM |
| DRACHMAN JONATHAN G | CMO & EVP, R & D | Jan 11, 2018 | Option Exercise | $11.06 | 19,416 | 214,705 | 170,934 | Jan 16, 2018, 08:04 PM |
| SIEGALL CLAY B | President and CEO | Dec 11, 2017 | Option Exercise | $11.09 | 18,832 | 208,847 | 698,933 | Dec 13, 2017, 08:50 PM |
| SIEGALL CLAY B | President and CEO | Dec 11, 2017 | Sale | $55.40 | 18,832 | 1,043,329 | 687,146 | Dec 13, 2017, 08:50 PM |
| LIU JEAN I | GC/EVP, Leg Affairs | Dec 04, 2017 | Option Exercise | $59.55 | 7,536 | 448,769 | 60,864 | Dec 06, 2017, 08:06 PM |
| DOBMEIER ERIC | Chief Operating Officer | Dec 04, 2017 | Option Exercise | $32.00 | 6,165 | 197,300 | 121,153 | Dec 06, 2017, 08:04 PM |
| DOBMEIER ERIC | Chief Operating Officer | Dec 04, 2017 | Sale | $58.75 | 3,729 | 219,092 | 117,424 | Dec 06, 2017, 08:04 PM |
| HIMES VAUGHN B | Chief Technical Officer | Nov 30, 2017 | Option Exercise | $12.16 | 10,000 | 121,573 | 172,306 | Dec 04, 2017, 07:54 PM |
| HIMES VAUGHN B | Chief Technical Officer | Nov 30, 2017 | Sale | $59.97 | 10,000 | 599,729 | 164,906 | Dec 04, 2017, 07:54 PM |
| LIPPMAN MARC E | Director | Nov 15, 2017 | Sale | $58.07 | 3,000 | 174,224 | 132,050 | Nov 17, 2017, 08:47 PM |
| DOBMEIER ERIC | Chief Operating Officer | Nov 17, 2017 | Option Exercise | $26.10 | 10,000 | 261,000 | 127,424 | Nov 17, 2017, 08:45 PM |
| DOBMEIER ERIC | Chief Operating Officer | Nov 16, 2017 | Option Exercise | $20.23 | 15,400 | 311,617 | 125,913 | Nov 17, 2017, 08:45 PM |
| DOBMEIER ERIC | Chief Operating Officer | Nov 15, 2017 | Option Exercise | $15.46 | 9,600 | 148,416 | 127,024 | Nov 17, 2017, 08:45 PM |
| DOBMEIER ERIC | Chief Operating Officer | Nov 17, 2017 | Sale | $59.13 | 10,000 | 591,250 | 117,424 | Nov 17, 2017, 08:45 PM |
| DOBMEIER ERIC | Chief Operating Officer | Nov 16, 2017 | Sale | $57.96 | 15,400 | 892,637 | 117,424 | Nov 17, 2017, 08:45 PM |
| DOBMEIER ERIC | Chief Operating Officer | Nov 15, 2017 | Sale | $57.80 | 9,600 | 554,837 | 117,424 | Nov 17, 2017, 08:45 PM |
| SIEGALL CLAY B | President and CEO | Nov 10, 2017 | Option Exercise | $11.09 | 18,832 | 208,847 | 704,255 | Nov 14, 2017, 07:40 PM |
| SIEGALL CLAY B | President and CEO | Nov 10, 2017 | Sale | $58.00 | 18,832 | 1,092,193 | 687,146 | Nov 14, 2017, 07:40 PM |
| SIMPSON TODD E | Chief Financial Officer | Nov 01, 2017 | Sale | $60.91 | 39,385 | 2,398,915 | 179,526 | Nov 03, 2017, 05:42 PM |
| SIEGALL CLAY B | President and CEO | Oct 11, 2017 | Option Exercise | $11.09 | 18,832 | 208,847 | 694,045 | Oct 13, 2017, 08:58 PM |
| SIEGALL CLAY B | President and CEO | Oct 11, 2017 | Sale | $61.18 | 18,832 | 1,152,234 | 687,146 | Oct 13, 2017, 08:58 PM |
| DRACHMAN JONATHAN G | CMO & EVP, R & D | Oct 05, 2017 | Option Exercise | $11.52 | 17,816 | 205,253 | 151,518 | Oct 10, 2017, 06:42 PM |
| SIEGALL CLAY B | President and CEO | Sep 26, 2017 | Option Exercise | $11.09 | 9,017 | 99,999 | 687,146 | Sep 28, 2017, 06:15 PM |
| SIEGALL CLAY B | President and CEO | Sep 11, 2017 | Option Exercise | $11.09 | 18,832 | 208,847 | 695,246 | Sep 12, 2017, 07:34 PM |
| SIEGALL CLAY B | President and CEO | Sep 11, 2017 | Sale | $53.49 | 18,832 | 1,007,257 | 678,129 | Sep 12, 2017, 07:34 PM |
| HIMES VAUGHN B | Chief Technical Officer | Sep 08, 2017 | Option Exercise | $11.23 | 10,000 | 112,329 | 171,742 | Sep 12, 2017, 07:32 PM |
| HIMES VAUGHN B | Chief Technical Officer | Sep 08, 2017 | Sale | $53.22 | 10,000 | 532,190 | 164,906 | Sep 12, 2017, 07:32 PM |
| SIMPSON TODD E | Chief Financial Officer | Sep 06, 2017 | Sale | $52.00 | 9,638 | 501,176 | 218,377 | Sep 08, 2017, 07:34 PM |
| Cline Darren S | EVP, Commercial | Sep 06, 2017 | Option Exercise | $15.93 | 10,048 | 160,115 | 82,254 | Sep 08, 2017, 07:32 PM |
| Cline Darren S | EVP, Commercial | Sep 06, 2017 | Sale | $51.94 | 5,024 | 260,967 | 77,230 | Sep 08, 2017, 07:32 PM |
| DOBMEIER ERIC | Chief Operating Officer | Aug 31, 2017 | Option Exercise | $15.46 | 25,000 | 386,500 | 142,424 | Sep 05, 2017, 07:25 PM |
| DOBMEIER ERIC | Chief Operating Officer | Aug 31, 2017 | Sale | $52.24 | 25,000 | 1,305,892 | 117,424 | Sep 05, 2017, 07:25 PM |
| Cline Darren S | EVP, Commercial | Aug 31, 2017 | Option Exercise | $18.46 | 2,907 | 53,663 | 79,775 | Sep 05, 2017, 07:23 PM |
| Cline Darren S | EVP, Commercial | Aug 31, 2017 | Sale | $52.51 | 7,569 | 397,466 | 76,868 | Sep 05, 2017, 07:23 PM |
| SIMPSON TODD E | Chief Financial Officer | Aug 28, 2017 | Sale | $47.89 | 4,937 | 236,455 | 228,015 | Aug 30, 2017, 07:27 PM |
| SIEGALL CLAY B | President and CEO | Aug 28, 2017 | Sale | $47.89 | 25,506 | 1,221,597 | 678,129 | Aug 30, 2017, 07:25 PM |
| HIMES VAUGHN B | Chief Technical Officer | Aug 28, 2017 | Sale | $47.89 | 6,377 | 305,423 | 164,906 | Aug 30, 2017, 07:24 PM |
| DRACHMAN JONATHAN G | CMO & EVP, R & D | Aug 28, 2017 | Sale | $47.89 | 8,502 | 407,199 | 133,702 | Aug 30, 2017, 07:23 PM |
| DOBMEIER ERIC | Chief Operating Officer | Aug 28, 2017 | Sale | $47.89 | 5,343 | 255,900 | 117,424 | Aug 30, 2017, 07:21 PM |
| Cline Darren S | EVP, Commercial | Aug 28, 2017 | Sale | $47.89 | 1,788 | 85,635 | 76,868 | Aug 30, 2017, 07:18 PM |
| DRACHMAN JONATHAN G | CMO & EVP, R & D | Aug 24, 2017 | Option Exercise | $10.29 | 10,000 | 102,900 | 152,204 | Aug 25, 2017, 07:52 PM |
| DRACHMAN JONATHAN G | CMO & EVP, R & D | Aug 24, 2017 | Sale | $47.54 | 10,000 | 475,414 | 142,204 | Aug 25, 2017, 07:52 PM |
| SIEGALL CLAY B | President and CEO | Aug 07, 2017 | Option Exercise | $10.29 | 10,413 | 107,150 | 646,848 | Aug 09, 2017, 06:58 PM |
| SIEGALL CLAY B | President and CEO | Aug 07, 2017 | Sale | $48.91 | 10,413 | 509,300 | 636,435 | Aug 09, 2017, 06:58 PM |
| Cline Darren S | EVP, Commercial | Aug 07, 2017 | Option Exercise | $18.46 | 6,000 | 110,760 | 67,656 | Aug 09, 2017, 06:52 PM |
| Cline Darren S | EVP, Commercial | Aug 07, 2017 | Sale | $49.19 | 6,000 | 295,110 | 61,656 | Aug 09, 2017, 06:52 PM |
| DRACHMAN JONATHAN G | CMO & EVP, R & D | Jul 27, 2017 | Option Exercise | $10.29 | 10,000 | 102,900 | 125,204 | Jul 31, 2017, 07:15 PM |
| DRACHMAN JONATHAN G | CMO & EVP, R & D | Jul 27, 2017 | Sale | $54.54 | 10,000 | 545,361 | 115,204 | Jul 31, 2017, 07:15 PM |
| SIEGALL CLAY B | President and CEO | Jul 05, 2017 | Option Exercise | $10.29 | 10,423 | 107,253 | 644,629 | Jul 07, 2017, 07:20 PM |
| SIEGALL CLAY B | President and CEO | Jul 05, 2017 | Sale | $51.98 | 10,423 | 541,807 | 636,435 | Jul 07, 2017, 07:20 PM |
| DRACHMAN JONATHAN G | CMO & EVP, R & D | Jun 22, 2017 | Option Exercise | $10.29 | 10,000 | 102,900 | 125,204 | Jun 26, 2017, 06:25 PM |
| DRACHMAN JONATHAN G | CMO & EVP, R & D | Jun 22, 2017 | Sale | $64.01 | 10,000 | 640,058 | 115,304 | Jun 26, 2017, 06:25 PM |
| SIEGALL CLAY B | President and CEO | Jun 05, 2017 | Option Exercise | $10.29 | 10,423 | 107,253 | 646,195 | Jun 07, 2017, 07:24 PM |
| SIEGALL CLAY B | President and CEO | Jun 05, 2017 | Sale | $65.21 | 10,423 | 679,698 | 636,435 | Jun 07, 2017, 07:24 PM |
| HIMES VAUGHN B | Chief Technical Officer | May 31, 2017 | Option Exercise | $9.23 | 10,000 | 92,300 | 160,683 | Jun 02, 2017, 07:08 PM |
| HIMES VAUGHN B | Chief Technical Officer | May 31, 2017 | Sale | $62.59 | 10,000 | 625,922 | 151,283 | Jun 02, 2017, 07:08 PM |
| BAKER BROS. ADVISORS LP | Director | May 19, 2017 | Option Exercise | $66.60 | 3,700 | 246,420 | 40,898,792 | May 23, 2017, 05:11 PM |
| BAKER BROS. ADVISORS LP | Director | May 19, 2017 | Option Exercise | $66.60 | 3,700 | 246,420 | 4,888,564 | May 23, 2017, 05:11 PM |
| BAKER BROS. ADVISORS LP | Director | May 15, 2017 | Option Exercise | $10.20 | 20,000 | 204,000 | 40,895,092 | May 17, 2017, 05:26 PM |
| SIEGALL CLAY B | President and CEO | May 05, 2017 | Option Exercise | $10.26 | 14,462 | 148,450 | 645,765 | May 09, 2017, 07:42 PM |
| SIEGALL CLAY B | President and CEO | May 05, 2017 | Sale | $61.74 | 14,462 | 892,897 | 636,435 | May 09, 2017, 07:42 PM |
| SIEGALL CLAY B | President and CEO | Apr 05, 2017 | Option Exercise | $10.26 | 14,465 | 148,481 | 646,858 | Apr 06, 2017, 08:10 PM |
| SIEGALL CLAY B | President and CEO | Apr 05, 2017 | Sale | $62.99 | 14,465 | 911,111 | 636,435 | Apr 06, 2017, 08:10 PM |
| HIMES VAUGHN B | Chief Technical Officer | Mar 31, 2017 | Option Exercise | $9.23 | 10,000 | 92,300 | 161,283 | Apr 04, 2017, 05:48 PM |
| HIMES VAUGHN B | Chief Technical Officer | Mar 31, 2017 | Sale | $62.75 | 10,000 | 627,527 | 151,283 | Apr 04, 2017, 05:48 PM |
| SIEGALL CLAY B | President and CEO | Mar 06, 2017 | Option Exercise | $10.26 | 14,465 | 148,481 | 646,858 | Mar 08, 2017, 07:22 PM |
| SIEGALL CLAY B | President and CEO | Mar 06, 2017 | Sale | $68.04 | 14,465 | 984,259 | 636,435 | Mar 08, 2017, 07:22 PM |
| SIEGALL CLAY B | President and CEO | Feb 06, 2017 | Option Exercise | $10.26 | 14,465 | 148,481 | 646,758 | Feb 08, 2017, 05:29 PM |
| SIEGALL CLAY B | President and CEO | Feb 06, 2017 | Sale | $61.54 | 14,465 | 890,164 | 636,435 | Feb 08, 2017, 05:29 PM |
| DRACHMAN JONATHAN G | CMO & EVP, R & D | Jan 25, 2017 | Option Exercise | $10.29 | 5,000 | 51,450 | 114,837 | Jan 26, 2017, 07:41 PM |
| SIEGALL CLAY B | President and CEO | Jan 06, 2017 | Option Exercise | $10.26 | 14,465 | 148,481 | 646,888 | Jan 10, 2017, 06:11 PM |
| SIEGALL CLAY B | President and CEO | Jan 06, 2017 | Sale | $57.89 | 14,465 | 837,425 | 638,835 | Jan 10, 2017, 06:11 PM |
| Cline Darren S | EVP, Commercial | Dec 16, 2016 | Option Exercise | $16.41 | 3,100 | 50,871 | 61,604 | Dec 20, 2016, 07:48 PM |
| Cline Darren S | EVP, Commercial | Dec 13, 2016 | Option Exercise | $24.45 | 12,761 | 311,968 | 65,743 | Dec 15, 2016, 07:26 PM |
| Cline Darren S | EVP, Commercial | Dec 13, 2016 | Sale | $63.38 | 10,000 | 633,834 | 58,504 | Dec 15, 2016, 07:26 PM |
| HIMES VAUGHN B | Chief Technical Officer | Dec 12, 2016 | Option Exercise | $16.89 | 15,632 | 263,980 | 151,011 | Dec 14, 2016, 05:35 PM |
| DOBMEIER ERIC | Chief Operating Officer | Dec 08, 2016 | Option Exercise | $20.52 | 12,500 | 256,500 | 97,467 | Dec 12, 2016, 07:24 PM |
| DOBMEIER ERIC | Chief Operating Officer | Dec 08, 2016 | Sale | $65.92 | 12,500 | 824,042 | 87,767 | Dec 12, 2016, 07:24 PM |
| HIMES VAUGHN B | Chief Technical Officer | Dec 07, 2016 | Option Exercise | $9.23 | 30,000 | 276,900 | 165,379 | Dec 08, 2016, 08:05 PM |
| HIMES VAUGHN B | Chief Technical Officer | Dec 07, 2016 | Sale | $65.32 | 30,000 | 1,959,744 | 136,806 | Dec 08, 2016, 08:05 PM |
| SIEGALL CLAY B | President and CEO | Dec 06, 2016 | Option Exercise | $10.26 | 14,465 | 148,481 | 649,258 | Dec 08, 2016, 08:03 PM |
| SIEGALL CLAY B | President and CEO | Dec 06, 2016 | Sale | $66.17 | 14,465 | 957,145 | 638,835 | Dec 08, 2016, 08:03 PM |
| DRACHMAN JONATHAN G | CMO & EVP, R & D | Nov 09, 2016 | Option Exercise | $11.09 | 7,751 | 85,959 | 117,588 | Nov 14, 2016, 05:55 PM |
| DRACHMAN JONATHAN G | CMO & EVP, R & D | Nov 09, 2016 | Sale | $66.75 | 7,751 | 517,379 | 109,837 | Nov 14, 2016, 05:55 PM |
| SIEGALL CLAY B | President and CEO | Nov 07, 2016 | Option Exercise | $10.26 | 14,465 | 148,481 | 645,948 | Nov 09, 2016, 07:16 PM |
| SIEGALL CLAY B | President and CEO | Nov 07, 2016 | Sale | $58.43 | 14,465 | 845,144 | 638,835 | Nov 09, 2016, 07:16 PM |
| LIPPMAN MARC E | Director | Nov 07, 2016 | Sale | $57.75 | 1,000 | 57,749 | 131,350 | Nov 09, 2016, 07:13 PM |
| BAKER FELIX | Director | Nov 08, 2016 | Buy | $59.46 | 326,300 | 19,403,299 | 40,885,092 | Nov 09, 2016, 04:37 PM |
| BAKER FELIX | Director | Nov 07, 2016 | Buy | $58.74 | 56,200 | 3,301,345 | 40,590,914 | Nov 09, 2016, 04:37 PM |
| DRACHMAN JONATHAN G | CMO & EVP, R & D | Nov 01, 2016 | Sale | $51.74 | 3,418 | 176,847 | 109,837 | Nov 03, 2016, 08:04 PM |
| BAKER FELIX | Director | Nov 03, 2016 | Buy | $56.43 | 198,433 | 11,196,763 | 40,540,247 | Nov 03, 2016, 06:12 PM |
| BAKER FELIX | Director | Nov 03, 2016 | Buy | $56.91 | 379,336 | 21,586,885 | 40,361,400 | Nov 03, 2016, 06:11 PM |
| BAKER FELIX | Director | Nov 02, 2016 | Buy | $56.15 | 466,619 | 26,200,958 | 40,019,506 | Nov 03, 2016, 06:11 PM |
| BAKER FELIX | Director | Nov 01, 2016 | Buy | $54.46 | 184,674 | 10,057,349 | 39,598,943 | Nov 03, 2016, 06:11 PM |
| SIEGALL CLAY B | President and CEO | Oct 06, 2016 | Option Exercise | $10.27 | 14,465 | 148,553 | 650,058 | Oct 11, 2016, 04:50 PM |
| SIEGALL CLAY B | President and CEO | Oct 06, 2016 | Sale | $54.41 | 14,465 | 787,022 | 638,835 | Oct 11, 2016, 04:50 PM |
| DRACHMAN JONATHAN G | CMO & EVP, R & D | Sep 22, 2016 | Option Exercise | $10.29 | 2,249 | 23,142 | 115,504 | Sep 23, 2016, 07:12 PM |
| DRACHMAN JONATHAN G | CMO & EVP, R & D | Sep 22, 2016 | Sale | $56.75 | 2,249 | 127,631 | 113,255 | Sep 23, 2016, 07:12 PM |
| DOBMEIER ERIC | Chief Operating Officer | Sep 14, 2016 | Option Exercise | $12.00 | 22,918 | 275,016 | 110,385 | Sep 15, 2016, 06:33 PM |
| DOBMEIER ERIC | Chief Operating Officer | Sep 14, 2016 | Sale | $54.04 | 22,918 | 1,238,469 | 87,767 | Sep 15, 2016, 06:33 PM |
| Cline Darren S | EVP, Commercial | Sep 09, 2016 | Option Exercise | $15.46 | 4,167 | 64,422 | 55,743 | Sep 13, 2016, 07:09 PM |
| BAKER FELIX | Director | Sep 13, 2016 | Buy | $51.09 | 141,202 | 7,213,981 | 39,432,496 | Sep 13, 2016, 06:05 PM |
| BAKER FELIX | Director | Sep 12, 2016 | Buy | $51.14 | 49,889 | 2,551,111 | 39,305,533 | Sep 13, 2016, 06:05 PM |
| BAKER FELIX | Director | Sep 09, 2016 | Buy | $50.42 | 256,220 | 12,917,842 | 39,260,675 | Sep 13, 2016, 06:05 PM |
| SIEGALL CLAY B | President and CEO | Sep 08, 2016 | Option Exercise | $10.29 | 31,269 | 321,758 | 648,307 | Sep 12, 2016, 09:52 PM |
| SIEGALL CLAY B | President and CEO | Sep 08, 2016 | Sale | $50.08 | 31,269 | 1,565,977 | 638,835 | Sep 12, 2016, 09:52 PM |
| SIEGALL CLAY B | President and CEO | Sep 06, 2016 | Option Exercise | $8.38 | 23,957 | 200,776 | 622,449 | Sep 08, 2016, 08:02 PM |
| SIEGALL CLAY B | President and CEO | Sep 06, 2016 | Sale | $45.40 | 11,653 | 529,007 | 617,038 | Sep 08, 2016, 08:02 PM |
| GRYSKA DAVID W | Director | Sep 06, 2016 | Option Exercise | $10.20 | 10,000 | 102,000 | 37,650 | Sep 08, 2016, 07:21 PM |
| Cline Darren S | EVP, Commercial | Sep 06, 2016 | Sale | $46.01 | 5,397 | 248,307 | 52,347 | Sep 08, 2016, 07:18 PM |
| BAKER FELIX | Director | Sep 08, 2016 | Buy | $50.12 | 211,093 | 10,579,529 | 39,030,368 | Sep 08, 2016, 05:39 PM |
| BAKER FELIX | Director | Sep 07, 2016 | Buy | $48.52 | 59,560 | 2,889,689 | 38,840,624 | Sep 08, 2016, 05:39 PM |
| BAKER FELIX | Director | Sep 06, 2016 | Buy | $45.90 | 143,363 | 6,580,527 | 4,643,343 | Sep 08, 2016, 05:39 PM |
| DOBMEIER ERIC | Chief Operating Officer | Aug 23, 2016 | Option Exercise | $26.10 | 3,831 | 99,989 | 71,356 | Aug 24, 2016, 06:50 PM |
| DOBMEIER ERIC | Chief Operating Officer | Aug 23, 2016 | Sale | $48.00 | 12,589 | 604,272 | 58,767 | Aug 24, 2016, 06:50 PM |
| Cline Darren S | EVP, Commercial | Aug 22, 2016 | Sale | $46.59 | 1,774 | 82,652 | 40,973 | Aug 22, 2016, 09:38 PM |
| DOBMEIER ERIC | Chief Operating Officer | Aug 22, 2016 | Sale | $46.59 | 5,411 | 252,102 | 67,525 | Aug 22, 2016, 09:36 PM |
| DRACHMAN JONATHAN G | CMO & EVP, R & D | Aug 22, 2016 | Sale | $46.59 | 3,991 | 185,943 | 84,255 | Aug 22, 2016, 09:34 PM |
| HIMES VAUGHN B | EVP, Proc Svcs & Tech Ops | Aug 22, 2016 | Sale | $46.59 | 3,991 | 185,943 | 108,779 | Aug 22, 2016, 09:33 PM |
| SIEGALL CLAY B | President and CEO | Aug 22, 2016 | Sale | $46.59 | 23,381 | 1,089,337 | 532,734 | Aug 22, 2016, 09:31 PM |
| SIMPSON TODD E | Chief Financial Officer | Aug 22, 2016 | Sale | $46.59 | 3,991 | 185,943 | 191,445 | Aug 22, 2016, 09:29 PM |
| DOBMEIER ERIC | Chief Operating Officer | Aug 24, 2015 | Option Exercise | $20.27 | 4,933 | 99,985 | 79,340 | Aug 22, 2016, 09:21 PM |
| DOBMEIER ERIC | Chief Operating Officer | Aug 20, 2015 | Sale | $42.02 | 8,548 | 359,226 | 74,407 | Aug 22, 2016, 09:21 PM |
| Cline Darren S | SVP, Commercial | Aug 20, 2015 | Sale | $42.02 | 2,231 | 93,757 | 31,482 | Aug 22, 2016, 09:19 PM |
| SIEGALL CLAY B | President and CEO | Aug 08, 2016 | Option Exercise | $6.44 | 11,660 | 75,128 | 563,733 | Aug 10, 2016, 07:47 PM |
| SIEGALL CLAY B | President and CEO | Aug 08, 2016 | Sale | $47.19 | 11,660 | 550,212 | 556,115 | Aug 10, 2016, 07:47 PM |
| SIEGALL CLAY B | President and CEO | Jul 27, 2016 | Option Exercise | $10.20 | 4,042 | 41,228 | 560,157 | Jul 29, 2016, 07:40 PM |
| SIEGALL CLAY B | President and CEO | Jul 27, 2016 | Sale | $45.20 | 4,042 | 182,718 | 556,115 | Jul 29, 2016, 07:40 PM |
| SIEGALL CLAY B | President and CEO | Jul 06, 2016 | Option Exercise | $4.45 | 7,618 | 33,900 | 561,287 | Jul 07, 2016, 08:11 PM |
| SIEGALL CLAY B | President and CEO | Jul 06, 2016 | Sale | $40.56 | 7,618 | 308,999 | 556,115 | Jul 07, 2016, 08:11 PM |
| SIEGALL CLAY B | President and CEO | Jun 06, 2016 | Option Exercise | $8.26 | 22,083 | 182,381 | 566,538 | Jun 08, 2016, 07:32 PM |
| SIEGALL CLAY B | President and CEO | Jun 06, 2016 | Sale | $43.59 | 22,083 | 962,668 | 556,115 | Jun 08, 2016, 07:32 PM |
| DRACHMAN JONATHAN G | CMO & EVP, R & D | Jun 02, 2016 | Option Exercise | $10.29 | 5,000 | 51,450 | 88,246 | Jun 06, 2016, 06:54 PM |
| Cline Darren S | EVP, Commercial | Jun 02, 2016 | Sale | $42.07 | 3,366 | 141,617 | 42,747 | Jun 06, 2016, 06:52 PM |
| SIEGALL CLAY B | President and CEO | May 25, 2016 | Option Exercise | $10.27 | 36,738 | 377,335 | 585,085 | May 27, 2016, 07:29 PM |
| SIEGALL CLAY B | President and CEO | May 27, 2016 | Option Exercise | $10.29 | 10,792 | 111,050 | 566,907 | May 27, 2016, 07:29 PM |
| SIEGALL CLAY B | President and CEO | May 26, 2016 | Option Exercise | $10.29 | 1,130 | 11,628 | 557,245 | May 27, 2016, 07:29 PM |
| SIEGALL CLAY B | President and CEO | May 27, 2016 | Sale | $40.10 | 10,792 | 432,810 | 556,115 | May 27, 2016, 07:29 PM |
| SIEGALL CLAY B | President and CEO | May 26, 2016 | Sale | $40.07 | 1,130 | 45,284 | 556,115 | May 27, 2016, 07:29 PM |
| SIEGALL CLAY B | President and CEO | May 25, 2016 | Sale | $40.51 | 36,738 | 1,488,275 | 556,115 | May 27, 2016, 07:29 PM |
| SIEGALL CLAY B | President and CEO | May 24, 2016 | Option Exercise | $10.20 | 1,700 | 17,340 | 557,815 | May 25, 2016, 07:04 PM |
| SIEGALL CLAY B | President and CEO | May 23, 2016 | Option Exercise | $10.20 | 6,700 | 68,340 | 562,815 | May 25, 2016, 07:04 PM |
| SIEGALL CLAY B | President and CEO | May 24, 2016 | Sale | $40.00 | 1,700 | 68,000 | 556,115 | May 25, 2016, 07:04 PM |
| SIEGALL CLAY B | President and CEO | May 23, 2016 | Sale | $40.12 | 6,700 | 268,777 | 556,115 | May 25, 2016, 07:04 PM |
| BAKER FELIX | Director | May 20, 2016 | Option Exercise | $38.82 | 7,400 | 287,268 | 38,787,087 | May 24, 2016, 05:50 PM |
| SIEGALL CLAY B | President and CEO | May 17, 2016 | Option Exercise | $4.45 | 7,618 | 33,900 | 563,733 | May 19, 2016, 03:14 PM |
| SIEGALL CLAY B | President and CEO | May 17, 2016 | Sale | $35.16 | 7,618 | 267,849 | 556,115 | May 19, 2016, 03:14 PM |
| SIEGALL CLAY B | President and CEO | Apr 25, 2016 | Option Exercise | $10.20 | 800 | 8,160 | 556,915 | Apr 26, 2016, 08:17 PM |
| SIEGALL CLAY B | President and CEO | Apr 25, 2016 | Sale | $40.00 | 800 | 32,000 | 556,115 | Apr 26, 2016, 08:17 PM |
| SIEGALL CLAY B | President and CEO | Apr 05, 2016 | Option Exercise | $4.45 | 7,618 | 33,900 | 563,733 | Apr 07, 2016, 04:49 PM |
| SIEGALL CLAY B | President and CEO | Apr 05, 2016 | Sale | $36.12 | 7,618 | 275,162 | 556,115 | Apr 07, 2016, 04:49 PM |
| SIEGALL CLAY B | President and CEO | Mar 22, 2016 | Option Exercise | $4.45 | 10,954 | 48,745 | 567,069 | Mar 23, 2016, 07:44 PM |
| SIEGALL CLAY B | President and CEO | Mar 21, 2016 | Option Exercise | $4.45 | 4,282 | 19,055 | 560,397 | Mar 23, 2016, 07:44 PM |
| SIEGALL CLAY B | President and CEO | Mar 21, 2016 | Sale | $35.01 | 4,282 | 149,913 | 556,115 | Mar 23, 2016, 07:44 PM |
| SIEGALL CLAY B | President and CEO | Mar 22, 2016 | Sale | $35.72 | 10,954 | 391,317 | 557,015 | Mar 23, 2016, 07:44 PM |
| BAKER FELIX | Director | Mar 17, 2016 | Buy | $31.85 | 124,065 | 3,951,304 | 38,783,387 | Mar 21, 2016, 04:32 PM |
| BAKER FELIX | Director | Mar 16, 2016 | Buy | $31.77 | 569,203 | 18,084,599 | 38,671,506 | Mar 16, 2016, 06:57 PM |
| BAKER FELIX | Director | Mar 15, 2016 | Buy | $32.08 | 661,093 | 21,210,834 | 38,158,204 | Mar 16, 2016, 06:57 PM |
| BAKER FELIX | Director | Mar 14, 2016 | Buy | $33.77 | 118,941 | 4,016,519 | 37,562,036 | Mar 16, 2016, 06:57 PM |
| BAKER FELIX | Director | Mar 11, 2016 | Buy | $33.10 | 195,765 | 6,480,738 | 37,454,776 | Mar 11, 2016, 06:13 PM |
| BAKER FELIX | Director | Mar 10, 2016 | Buy | $32.34 | 290,231 | 9,386,567 | 37,278,782 | Mar 11, 2016, 06:13 PM |
| BAKER FELIX | Director | Mar 09, 2016 | Buy | $32.03 | 208,670 | 6,683,985 | 37,017,863 | Mar 11, 2016, 06:13 PM |
| WELCH DANIEL G | Director | Mar 08, 2016 | Option Exercise | $9.82 | 25,000 | 245,500 | 41,819 | Mar 10, 2016, 03:16 PM |
| BAKER FELIX | Director | Mar 08, 2016 | Option Exercise | $4.18 | 20,000 | 83,600 | 36,692,540 | Mar 08, 2016, 05:04 PM |
| BAKER FELIX | Director | Mar 07, 2016 | Buy | $33.69 | 61,265 | 2,063,918 | 36,682,540 | Mar 08, 2016, 05:04 PM |
| BAKER FELIX | Director | Mar 04, 2016 | Buy | $32.36 | 288,058 | 9,322,814 | 36,627,462 | Mar 08, 2016, 05:04 PM |
| BAKER FELIX | Director | Mar 02, 2016 | Buy | $32.67 | 400,000 | 13,068,812 | 36,367,808 | Mar 02, 2016, 06:31 PM |
| BAKER FELIX | Director | Mar 01, 2016 | Buy | $31.24 | 24,200 | 756,112 | 36,007,250 | Mar 02, 2016, 06:31 PM |
| BAKER FELIX | Director | Feb 29, 2016 | Buy | $30.39 | 251,722 | 7,650,310 | 35,985,436 | Mar 02, 2016, 06:31 PM |
| BAKER FELIX | Director | Feb 26, 2016 | Buy | $30.13 | 44,300 | 1,334,945 | 35,758,535 | Feb 26, 2016, 05:42 PM |
| BAKER FELIX | Director | Feb 25, 2016 | Buy | $29.86 | 142,702 | 4,261,553 | 35,718,720 | Feb 26, 2016, 05:42 PM |
| BAKER FELIX | Director | Feb 24, 2016 | Buy | $28.99 | 127,506 | 3,696,568 | 35,590,465 | Feb 26, 2016, 05:42 PM |
| BAKER FELIX | Director | Feb 22, 2016 | Buy | $30.21 | 243,411 | 7,354,639 | 35,475,868 | Feb 22, 2016, 05:34 PM |
| BAKER FELIX | Director | Feb 19, 2016 | Buy | $29.20 | 506,526 | 14,790,560 | 35,257,100 | Feb 22, 2016, 05:34 PM |
| BAKER FELIX | Director | Feb 18, 2016 | Buy | $29.94 | 251,534 | 7,530,350 | 34,800,251 | Feb 22, 2016, 05:34 PM |
| Orwin John A | Director | Feb 12, 2016 | Buy | $28.33 | 2,000 | 56,660 | 10,700 | Feb 17, 2016, 07:50 PM |
| BAKER FELIX | Director | Feb 17, 2016 | Buy | $31.25 | 805,267 | 25,161,937 | 34,573,386 | Feb 17, 2016, 06:05 PM |
| BAKER FELIX | Director | Feb 16, 2016 | Buy | $29.80 | 270,163 | 8,049,663 | 33,847,095 | Feb 17, 2016, 06:05 PM |
| BAKER FELIX | Director | Feb 12, 2016 | Buy | $27.93 | 193,717 | 5,410,745 | 33,588,605 | Feb 17, 2016, 06:05 PM |
| HIMES VAUGHN B | EVP, Proc Svcs & Tech Ops | Dec 18, 2015 | Option Exercise | $9.47 | 35,036 | 331,692 | 111,248 | Dec 21, 2015, 05:01 PM |
| HIMES VAUGHN B | EVP, Proc Svcs & Tech Ops | Dec 15, 2015 | Option Exercise | $9.23 | 40,500 | 373,815 | 116,712 | Dec 16, 2015, 08:29 PM |
| HIMES VAUGHN B | EVP, Proc Svcs & Tech Ops | Dec 15, 2015 | Sale | $39.94 | 40,500 | 1,617,493 | 76,212 | Dec 16, 2015, 08:29 PM |
| SIEGALL CLAY B | President and CEO | Dec 03, 2015 | Option Exercise | $5.63 | 3,720 | 20,944 | 559,835 | Dec 04, 2015, 06:01 PM |
| SIEGALL CLAY B | President and CEO | Dec 03, 2015 | Sale | $39.99 | 3,720 | 148,763 | 556,115 | Dec 04, 2015, 06:01 PM |
| BAKER FELIX | Director | Nov 18, 2015 | Buy | $43.61 | 14,638 | 638,321 | 33,114,132 | Nov 20, 2015, 05:02 PM |
| BAKER FELIX | Director | Nov 20, 2015 | Buy | $43.98 | 181,647 | 7,988,259 | 33,428,852 | Nov 20, 2015, 05:02 PM |
| BAKER FELIX | Director | Nov 19, 2015 | Buy | $43.93 | 133,073 | 5,845,378 | 33,247,205 | Nov 20, 2015, 05:02 PM |
| SIEGALL CLAY B | President and CEO | Nov 17, 2015 | Sale | $45.40 | 87,473 | 3,970,951 | 556,115 | Nov 19, 2015, 05:18 PM |
| Cline Darren S | SVP, Commercial | Nov 11, 2015 | Sale | $45.68 | 5,769 | 263,548 | 37,713 | Nov 13, 2015, 05:49 PM |
| BAKER FELIX | Director | Nov 10, 2015 | Buy | $44.00 | 9,400 | 413,600 | 33,099,494 | Nov 10, 2015, 07:57 PM |
| BAKER FELIX | Director | Nov 09, 2015 | Buy | $43.76 | 507,300 | 22,200,588 | 33,090,094 | Nov 10, 2015, 07:57 PM |
| BAKER FELIX | Director | Nov 06, 2015 | Buy | $41.94 | 417,924 | 17,529,497 | 32,582,794 | Nov 10, 2015, 07:57 PM |
| DOBMEIER ERIC | Chief Operating Officer | Nov 06, 2015 | Sale | $42.50 | 17,452 | 741,710 | 80,888 | Nov 06, 2015, 07:35 PM |
| SIEGALL CLAY B | President and CEO | Nov 04, 2015 | Option Exercise | $5.63 | 3,718 | 20,932 | 647,306 | Nov 05, 2015, 05:46 PM |
| SIEGALL CLAY B | President and CEO | Nov 04, 2015 | Sale | $43.14 | 3,718 | 160,395 | 643,588 | Nov 05, 2015, 05:46 PM |
| GRYSKA DAVID W | Director | Nov 05, 2015 | Sale | $43.57 | 10,000 | 435,737 | 23,950 | Nov 05, 2015, 05:17 PM |
| SIEGALL CLAY B | President and CEO | Oct 28, 2015 | Option Exercise | $5.12 | 32,265 | 165,058 | 643,588 | Oct 29, 2015, 08:30 PM |
| SIEGALL CLAY B | President and CEO | Oct 05, 2015 | Option Exercise | $5.63 | 3,718 | 20,932 | 615,041 | Oct 07, 2015, 04:47 PM |
| SIEGALL CLAY B | President and CEO | Oct 05, 2015 | Sale | $41.30 | 3,718 | 153,541 | 611,323 | Oct 07, 2015, 04:47 PM |
| SIMPSON TODD E | Chief Financial Officer | Sep 29, 2015 | Option Exercise | $13.51 | 14,801 | 199,991 | 194,675 | Oct 01, 2015, 03:10 PM |
| BAKER FELIX | Director | Sep 15, 2015 | Buy | $48.28 | 626,259 | 30,237,807 | 32,164,870 | Sep 15, 2015, 07:04 PM |
| BAKER FELIX | Director | Sep 14, 2015 | Buy | $46.34 | 320,438 | 14,849,199 | 31,538,611 | Sep 15, 2015, 07:04 PM |
| BAKER FELIX | Director | Sep 11, 2015 | Buy | $41.43 | 4,212,787 | 174,517,109 | 31,218,173 | Sep 15, 2015, 07:04 PM |
| SIEGALL CLAY B | President and CEO | Sep 03, 2015 | Option Exercise | $5.63 | 3,718 | 20,932 | 615,041 | Sep 04, 2015, 06:29 PM |
| SIEGALL CLAY B | President and CEO | Sep 03, 2015 | Sale | $40.12 | 3,718 | 149,166 | 611,323 | Sep 04, 2015, 06:29 PM |
| SIEGALL CLAY B | President and CEO | Aug 20, 2015 | Sale | $42.02 | 31,754 | 1,334,440 | 525,268 | Aug 25, 2015, 09:28 PM |
| DOBMEIER ERIC | Chief Operating Officer | Aug 24, 2015 | Option Exercise | $20.27 | 4,933 | 99,985 | 79,340 | Aug 25, 2015, 08:59 PM |
| DOBMEIER ERIC | Chief Operating Officer | Aug 20, 2015 | Sale | $42.02 | 8,548 | 359,226 | 74,407 | Aug 25, 2015, 08:59 PM |
| DRACHMAN JONATHAN G | CMO & EVP, R & D | Aug 20, 2015 | Sale | $42.02 | 4,462 | 187,513 | 62,724 | Aug 25, 2015, 08:48 PM |
| Cline Darren S | SVP, Commercial | Aug 20, 2015 | Sale | $42.02 | 2,231 | 93,757 | 31,482 | Aug 25, 2015, 08:46 PM |
| SIMPSON TODD E | Chief Financial Officer | Aug 20, 2015 | Sale | $42.02 | 5,825 | 244,794 | 162,874 | Aug 25, 2015, 08:32 PM |
| HIMES VAUGHN B | EVP, Proc Svcs & Tech Ops | Aug 20, 2015 | Sale | $42.02 | 5,997 | 252,021 | 61,212 | Aug 25, 2015, 08:30 PM |
| SIEGALL CLAY B | President and CEO | Aug 05, 2015 | Option Exercise | $5.63 | 3,718 | 20,932 | 560,740 | Aug 07, 2015, 05:46 PM |
| SIEGALL CLAY B | President and CEO | Aug 05, 2015 | Sale | $46.91 | 3,718 | 174,411 | 557,022 | Aug 07, 2015, 05:46 PM |
| SIEGALL CLAY B | President and CEO | Jul 06, 2015 | Option Exercise | $5.63 | 3,718 | 20,932 | 560,740 | Jul 08, 2015, 06:07 PM |
| SIEGALL CLAY B | President and CEO | Jul 06, 2015 | Sale | $46.94 | 3,718 | 174,515 | 557,022 | Jul 08, 2015, 06:07 PM |
| SIEGALL CLAY B | President and CEO | Jun 03, 2015 | Option Exercise | $5.63 | 3,718 | 20,932 | 560,740 | Jun 04, 2015, 06:10 PM |
| SIEGALL CLAY B | President and CEO | Jun 03, 2015 | Sale | $45.72 | 3,718 | 169,971 | 557,022 | Jun 04, 2015, 06:10 PM |
| BAKER FELIX | Director | May 21, 2015 | Buy | $43.38 | 362,459 | 15,723,084 | 27,005,386 | May 21, 2015, 07:42 PM |
| BAKER FELIX | Director | May 20, 2015 | Buy | $42.56 | 374,298 | 15,929,272 | 26,652,609 | May 21, 2015, 07:42 PM |
| BAKER FELIX | Director | May 19, 2015 | Buy | $40.87 | 214,129 | 8,751,249 | 26,268,629 | May 21, 2015, 07:42 PM |
| BAKER FELIX | Director | May 15, 2015 | Option Exercise | $39.94 | 7,400 | 295,556 | 26,054,500 | May 18, 2015, 06:45 PM |
| SIEGALL CLAY B | President and CEO | May 08, 2015 | Option Exercise | $5.63 | 52,052 | 293,053 | 609,074 | May 12, 2015, 07:31 PM |
| SIEGALL CLAY B | President and CEO | May 08, 2015 | Sale | $40.65 | 52,052 | 2,116,080 | 557,022 | May 12, 2015, 07:31 PM |
| BAKER FELIX | Director | May 11, 2015 | Option Exercise | $5.11 | 20,000 | 102,200 | 26,050,800 | May 12, 2015, 09:04 AM |
| DOBMEIER ERIC | Chief Operating Officer | May 08, 2015 | Sale | $40.38 | 17,074 | 689,380 | 82,777 | May 08, 2015, 06:50 PM |
| BAKER FELIX | Director | May 07, 2015 | Buy | $37.15 | 47,717 | 1,772,790 | 26,040,800 | May 07, 2015, 09:32 PM |
| BAKER FELIX | Director | May 06, 2015 | Buy | $36.41 | 453,995 | 16,530,995 | 25,993,083 | May 07, 2015, 09:32 PM |
| BAKER FELIX | Director | May 05, 2015 | Buy | $34.69 | 530,952 | 18,419,925 | 25,539,088 | May 07, 2015, 09:32 PM |
| GRYSKA DAVID W | Director | Apr 08, 2015 | Option Exercise | $8.38 | 5,000 | 41,900 | 30,250 | Apr 10, 2015, 06:43 PM |
| Cline Darren S | SVP, Commercial | Mar 13, 2015 | Sale | $38.65 | 7,500 | 289,876 | 33,135 | Mar 17, 2015, 07:10 PM |
| HIMES VAUGHN B | EVP, Proc Svcs & Tech Ops | Mar 12, 2015 | Option Exercise | $9.23 | 20,000 | 184,600 | 87,209 | Mar 16, 2015, 07:23 PM |
| HIMES VAUGHN B | EVP, Proc Svcs & Tech Ops | Mar 12, 2015 | Sale | $36.65 | 20,000 | 732,992 | 67,209 | Mar 16, 2015, 07:23 PM |
| BAKER FELIX | Director | Mar 10, 2015 | Buy | $34.54 | 9,319 | 321,921 | 25,008,136 | Mar 11, 2015, 06:55 PM |
| BAKER FELIX | Director | Mar 09, 2015 | Buy | $34.66 | 275,717 | 9,556,609 | 24,998,817 | Mar 11, 2015, 06:55 PM |
| BAKER FELIX | Director | Mar 04, 2015 | Buy | $34.82 | 23,621 | 822,418 | 24,723,100 | Mar 05, 2015, 06:02 PM |
| BAKER FELIX | Director | Mar 03, 2015 | Buy | $34.84 | 425,220 | 14,814,701 | 24,699,479 | Mar 05, 2015, 06:02 PM |
| BAKER FELIX | Director | Feb 24, 2015 | Buy | $33.76 | 217,465 | 7,341,491 | 24,210,609 | Feb 26, 2015, 07:12 PM |
| BAKER FELIX | Director | Feb 25, 2015 | Buy | $34.48 | 63,650 | 2,194,758 | 24,274,259 | Feb 26, 2015, 07:12 PM |
| SIEGALL CLAY B | President and CEO | Jan 06, 2015 | Option Exercise | $5.92 | 16,804 | 99,480 | 576,514 | Jan 08, 2015, 05:47 PM |
| SIEGALL CLAY B | President and CEO | Jan 06, 2015 | Sale | $31.80 | 16,804 | 534,320 | 559,710 | Jan 08, 2015, 05:47 PM |
| BAKER FELIX | Director | Dec 16, 2014 | Buy | $31.94 | 1,909,979 | 60,997,871 | 23,993,144 | Dec 17, 2014, 05:00 PM |
| BAKER FELIX | Director | Dec 15, 2014 | Buy | $31.70 | 973,399 | 30,861,289 | 22,083,165 | Dec 17, 2014, 05:00 PM |
| BAKER FELIX | Director | Dec 10, 2014 | Buy | $34.40 | 654,150 | 22,501,700 | 21,109,766 | Dec 10, 2014, 08:04 PM |
| BAKER FELIX | Director | Dec 09, 2014 | Buy | $34.16 | 128,430 | 4,387,345 | 20,455,616 | Dec 10, 2014, 08:04 PM |
| BAKER FELIX | Director | Dec 08, 2014 | Buy | $32.93 | 465,316 | 15,320,685 | 20,327,186 | Dec 10, 2014, 08:04 PM |
| HIMES VAUGHN B | EVP, Tech. Ops. & Proc. Sci. | Nov 12, 2014 | Option Exercise | $9.23 | 10,000 | 92,300 | 77,209 | Nov 14, 2014, 05:13 PM |
| HIMES VAUGHN B | EVP, Tech. Ops. & Proc. Sci. | Nov 12, 2014 | Sale | $37.52 | 10,000 | 375,169 | 67,209 | Nov 14, 2014, 05:13 PM |
| BAKER FELIX | Director | Nov 06, 2014 | Buy | $33.98 | 1,200,972 | 40,805,170 | 19,408,917 | Nov 10, 2014, 06:52 PM |
| BAKER FELIX | Director | Nov 10, 2014 | Buy | $36.43 | 241,249 | 8,787,529 | 19,861,870 | Nov 10, 2014, 06:52 PM |
| BAKER FELIX | Director | Nov 07, 2014 | Buy | $35.72 | 211,704 | 7,561,461 | 19,620,621 | Nov 10, 2014, 06:52 PM |
| SIEGALL CLAY B | President and CEO | Sep 04, 2014 | Option Exercise | $5.92 | 5,600 | 33,152 | 565,310 | Sep 05, 2014, 07:19 PM |
| SIEGALL CLAY B | President and CEO | Sep 04, 2014 | Sale | $42.54 | 5,600 | 238,224 | 559,710 | Sep 05, 2014, 07:19 PM |
| DOBMEIER ERIC | Chief Operating Officer | Aug 27, 2014 | Option Exercise | $12.00 | 8,333 | 99,996 | 99,765 | Aug 28, 2014, 04:27 PM |
| SIMPSON TODD E | Chief Financial Officer | Aug 24, 2014 | Sale | $43.55 | 3,696 | 160,957 | 151,699 | Aug 27, 2014, 04:25 PM |
| SIEGALL CLAY B | President and CEO | Aug 24, 2014 | Sale | $43.55 | 25,507 | 1,110,804 | 499,710 | Aug 27, 2014, 04:25 PM |
| HIMES VAUGHN B | EVP, Tech. Ops. & Proc. Sci. | Aug 24, 2014 | Sale | $43.55 | 3,310 | 144,147 | 52,209 | Aug 27, 2014, 04:24 PM |
| DRACHMAN JONATHAN G | CMO & EVP, R & D | Aug 24, 2014 | Sale | $43.55 | 2,772 | 120,718 | 46,481 | Aug 27, 2014, 04:24 PM |
| DOBMEIER ERIC | Chief Operating Officer | Aug 25, 2014 | Sale | $43.55 | 4,818 | 209,819 | 73,432 | Aug 27, 2014, 04:23 PM |
| BOERNER CHRISTOPHER S. | Executive Vice President, Comm | Aug 24, 2014 | Sale | $43.55 | 1,248 | 54,349 | 56,358 | Aug 27, 2014, 04:22 PM |
| SIEGALL CLAY B | President and CEO | Aug 12, 2014 | Option Exercise | $5.92 | 8,500 | 50,320 | 533,717 | Aug 13, 2014, 07:28 PM |
| SIEGALL CLAY B | President and CEO | Aug 11, 2014 | Option Exercise | $5.92 | 2,700 | 15,984 | 527,917 | Aug 13, 2014, 07:28 PM |
| SIEGALL CLAY B | President and CEO | Aug 12, 2014 | Sale | $40.48 | 8,500 | 344,090 | 525,217 | Aug 13, 2014, 07:28 PM |
| SIEGALL CLAY B | President and CEO | Aug 11, 2014 | Sale | $40.05 | 2,700 | 108,130 | 525,217 | Aug 13, 2014, 07:28 PM |
| BAKER FELIX | Director | Jun 12, 2014 | Buy | $39.94 | 128,008 | 5,112,199 | 18,121,499 | Jun 16, 2014, 04:33 PM |
| BAKER FELIX | Director | Jun 13, 2014 | Buy | $39.89 | 88,587 | 3,533,526 | 18,207,945 | Jun 16, 2014, 04:33 PM |
| SIEGALL CLAY B | President and CEO | Jun 10, 2014 | Option Exercise | $5.92 | 11,200 | 66,304 | 536,417 | Jun 12, 2014, 08:33 PM |
| SIEGALL CLAY B | President and CEO | Jun 10, 2014 | Sale | $40.14 | 11,200 | 449,574 | 525,217 | Jun 12, 2014, 08:33 PM |
| BAKER FELIX | Director | Jun 09, 2014 | Buy | $38.92 | 251,093 | 9,772,651 | 17,996,584 | Jun 09, 2014, 05:26 PM |
| BAKER FELIX | Director | Jun 06, 2014 | Buy | $37.41 | 174,987 | 6,546,471 | 17,751,559 | Jun 09, 2014, 05:26 PM |
| BAKER FELIX | Director | Jun 05, 2014 | Buy | $37.67 | 120,172 | 4,526,317 | 17,580,806 | Jun 09, 2014, 05:26 PM |
| BAKER FELIX | Director | Jun 04, 2014 | Buy | $36.13 | 87,042 | 3,145,161 | 17,463,541 | Jun 04, 2014, 07:27 PM |
| BAKER FELIX | Director | Jun 03, 2014 | Buy | $34.47 | 100,304 | 3,457,722 | 17,378,605 | Jun 04, 2014, 07:27 PM |
| BAKER FELIX | Director | Jun 02, 2014 | Buy | $34.09 | 94,617 | 3,225,210 | 17,280,727 | Jun 04, 2014, 07:27 PM |
| BAKER FELIX | Director | May 14, 2014 | Option Exercise | $7.26 | 30,000 | 217,800 | 16,999,872 | May 16, 2014, 07:00 PM |
| BAKER FELIX | Director | May 16, 2014 | Buy | $34.05 | 168,411 | 5,734,196 | 17,188,399 | May 16, 2014, 07:00 PM |
| BAKER FELIX | Director | May 15, 2014 | Buy | $34.26 | 21,200 | 726,356 | 17,020,560 | May 16, 2014, 07:00 PM |
| BAKER FELIX | Director | May 09, 2014 | Buy | $34.16 | 138,073 | 4,715,922 | 16,989,872 | May 16, 2014, 04:52 PM |
| BAKER FELIX | Director | May 08, 2014 | Buy | $34.02 | 233,055 | 7,929,305 | 16,855,137 | May 16, 2014, 04:52 PM |
| BAKER FELIX | Director | May 07, 2014 | Buy | $33.59 | 117,254 | 3,938,140 | 16,627,717 | May 16, 2014, 04:52 PM |
| HIMES VAUGHN B | EVP, Tech. Ops. & Proc. Sci. | May 09, 2014 | Option Exercise | $9.23 | 10,000 | 92,300 | 65,519 | May 13, 2014, 08:42 PM |
| HIMES VAUGHN B | EVP, Tech. Ops. & Proc. Sci. | May 09, 2014 | Sale | $35.00 | 10,000 | 350,000 | 55,519 | May 13, 2014, 08:42 PM |
| BAKER FELIX | Director | May 09, 2013 | Buy | $34.16 | 138,073 | 4,715,922 | 16,989,872 | May 09, 2014, 05:16 PM |
| BAKER FELIX | Director | May 08, 2013 | Buy | $34.02 | 233,055 | 7,929,305 | 16,855,137 | May 09, 2014, 05:16 PM |
| BAKER FELIX | Director | May 07, 2013 | Buy | $33.59 | 117,254 | 3,938,140 | 16,627,717 | May 09, 2014, 05:16 PM |
| SIEGALL CLAY B | President and CEO | Apr 03, 2014 | Option Exercise | $5.92 | 5,600 | 33,152 | 961,296 | Apr 07, 2014, 06:32 PM |
| SIEGALL CLAY B | President and CEO | Apr 03, 2014 | Sale | $43.34 | 5,600 | 242,702 | 955,696 | Apr 07, 2014, 06:32 PM |
| SIEGALL CLAY B | President and CEO | Mar 05, 2014 | Option Exercise | $5.80 | 9,318 | 54,084 | 961,296 | Mar 07, 2014, 08:05 PM |
| SIEGALL CLAY B | President and CEO | Mar 05, 2014 | Sale | $52.89 | 9,318 | 492,796 | 955,696 | Mar 07, 2014, 08:05 PM |
| HIMES VAUGHN B | EVP, Tech. Ops. & Proc. Sci. | Feb 28, 2014 | Option Exercise | $9.23 | 11,300 | 104,299 | 55,519 | Mar 04, 2014, 06:47 PM |
| BERGER FRANKLIN M | Director | Feb 21, 2014 | Option Exercise | $12.76 | 7,500 | 95,700 | 204,720 | Feb 25, 2014, 06:04 PM |
| BOERNER CHRISTOPHER S. | SVP, Commercial | Feb 21, 2014 | Sale | $54.98 | 1,452 | 79,825 | 46,075 | Feb 25, 2014, 03:35 PM |
| DRACHMAN JONATHAN G | CMO & EVP, R & D | Feb 20, 2014 | Sale | $53.25 | 1,241 | 66,083 | 48,670 | Feb 24, 2014, 07:25 PM |
| HIMES VAUGHN B | EVP, Tech, Ops. & Proc. Sci. | Feb 19, 2014 | Option Exercise | $9.23 | 3,000 | 27,690 | 49,307 | Feb 21, 2014, 06:39 PM |
| HIMES VAUGHN B | EVP, Tech, Ops. & Proc. Sci. | Feb 19, 2014 | Sale | $52.01 | 5,088 | 264,627 | 46,307 | Feb 21, 2014, 06:39 PM |
| SIEGALL CLAY B | President and CEO | Feb 13, 2014 | Option Exercise | $10.33 | 12,142 | 125,427 | 1,055,696 | Feb 18, 2014, 07:45 PM |
| SIEGALL CLAY B | President and CEO | Feb 18, 2014 | Sale | $51.97 | 100,000 | 5,197,010 | 955,696 | Feb 18, 2014, 07:45 PM |
| DOBMEIER ERIC | Chief Operating Officer | Jan 21, 2014 | Sale | $47.92 | 56,010 | 2,683,958 | 112,408 | Jan 23, 2014, 08:52 PM |
| DRACHMAN JONATHAN G | CMO & EVP, R & D | Jan 16, 2014 | Sale | $45.75 | 1,201 | 54,946 | 49,911 | Jan 21, 2014, 07:44 PM |
| SIEGALL CLAY B | President and CEO | Jan 02, 2014 | Option Exercise | $10.33 | 1,858 | 19,193 | 1,045,412 | Jan 06, 2014, 06:46 PM |
| SIEGALL CLAY B | President and CEO | Jan 02, 2014 | Sale | $39.27 | 1,858 | 72,957 | 1,043,554 | Jan 06, 2014, 06:46 PM |
| BAKER FELIX | Director | Dec 12, 2013 | Buy | $39.59 | 284,610 | 11,268,201 | 16,393,812 | Dec 16, 2013, 07:42 PM |
| BAKER FELIX | Director | Dec 16, 2013 | Buy | $39.92 | 78,759 | 3,143,952 | 16,513,298 | Dec 16, 2013, 07:42 PM |
| BAKER FELIX | Director | Dec 13, 2013 | Buy | $39.65 | 43,709 | 1,733,276 | 16,436,458 | Dec 16, 2013, 07:42 PM |
| SIEGALL CLAY B | President and CEO | Dec 05, 2013 | Option Exercise | $5.92 | 18,996 | 112,456 | 1,043,554 | Dec 09, 2013, 06:38 PM |
| BAKER FELIX | Director | Dec 05, 2013 | Buy | $44.00 | 365,676 | 16,089,489 | 16,116,121 | Dec 05, 2013, 08:13 PM |
| BAKER FELIX | Director | Dec 04, 2013 | Buy | $43.11 | 270,795 | 11,675,184 | 15,759,353 | Dec 05, 2013, 08:13 PM |
| BAKER FELIX | Director | Dec 03, 2013 | Buy | $42.44 | 369,430 | 15,678,059 | 15,495,154 | Dec 05, 2013, 08:13 PM |
| SIEGALL CLAY B | President and CEO | Dec 02, 2013 | Option Exercise | $10.33 | 2,000 | 20,660 | 1,026,558 | Dec 04, 2013, 05:42 PM |
| SIEGALL CLAY B | President and CEO | Dec 02, 2013 | Sale | $41.25 | 2,000 | 82,492 | 1,024,558 | Dec 04, 2013, 05:42 PM |
| SIEGALL CLAY B | President and CEO | Nov 01, 2013 | Option Exercise | $10.33 | 2,000 | 20,660 | 1,026,558 | Nov 05, 2013, 06:25 PM |
| SIEGALL CLAY B | President and CEO | Nov 01, 2013 | Sale | $38.63 | 2,000 | 77,254 | 1,024,558 | Nov 05, 2013, 06:25 PM |
| SIEGALL CLAY B | President and CEO | Oct 01, 2013 | Option Exercise | $10.33 | 2,000 | 20,660 | 1,026,558 | Oct 03, 2013, 07:36 PM |
| SIEGALL CLAY B | President and CEO | Oct 01, 2013 | Sale | $43.87 | 2,000 | 87,732 | 1,024,558 | Oct 03, 2013, 07:36 PM |
| DOBMEIER ERIC | Chief Operating Officer | Sep 10, 2013 | Option Exercise | $22.24 | 40,000 | 889,599 | 156,155 | Sep 11, 2013, 07:00 PM |
| DOBMEIER ERIC | Chief Operating Officer | Sep 10, 2013 | Sale | $46.40 | 42,000 | 1,948,960 | 135,843 | Sep 11, 2013, 07:00 PM |
| DOBMEIER ERIC | Chief Operating Officer | Sep 05, 2013 | Option Exercise | $15.46 | 15,000 | 231,900 | 150,843 | Sep 05, 2013, 07:17 PM |
| DOBMEIER ERIC | Chief Operating Officer | Sep 03, 2013 | Option Exercise | $13.28 | 68,223 | 905,685 | 165,036 | Sep 05, 2013, 07:17 PM |
| DOBMEIER ERIC | Chief Operating Officer | Sep 05, 2013 | Sale | $44.00 | 15,000 | 660,000 | 135,843 | Sep 05, 2013, 07:17 PM |
| DOBMEIER ERIC | Chief Operating Officer | Sep 03, 2013 | Sale | $42.29 | 60,000 | 2,537,664 | 135,843 | Sep 05, 2013, 07:17 PM |
| SIEGALL CLAY B | President and CEO | Sep 03, 2013 | Option Exercise | $10.33 | 2,000 | 20,660 | 1,079,211 | Sep 05, 2013, 05:55 PM |
| SIEGALL CLAY B | President and CEO | Sep 03, 2013 | Sale | $43.90 | 102,000 | 4,477,802 | 1,077,211 | Sep 05, 2013, 05:55 PM |
| GRYSKA DAVID W | Director | Sep 03, 2013 | Option Exercise | $10.08 | 10,000 | 100,800 | 32,000 | Sep 05, 2013, 05:53 PM |
| GRYSKA DAVID W | Director | Sep 03, 2013 | Sale | $42.48 | 10,000 | 424,800 | 22,000 | Sep 05, 2013, 05:53 PM |
| SIMPSON TODD E | Chief Financial Officer | Aug 28, 2013 | Option Exercise | $11.03 | 30,366 | 335,057 | 155,395 | Aug 30, 2013, 04:30 PM |
| SIMPSON TODD E | Chief Financial Officer | Aug 27, 2013 | Option Exercise | $21.73 | 37,763 | 820,546 | 137,529 | Aug 30, 2013, 04:30 PM |
| SIMPSON TODD E | Chief Financial Officer | Aug 27, 2013 | Sale | $41.45 | 37,763 | 1,565,186 | 125,029 | Aug 30, 2013, 04:30 PM |
| BERGER FRANKLIN M | Director | Aug 28, 2013 | Option Exercise | $12.76 | 10,000 | 127,600 | 197,220 | Aug 30, 2013, 04:30 PM |
| SIEGALL CLAY B | President and CEO | Aug 19, 2013 | Sale | $40.91 | 7,653 | 313,084 | 1,069,558 | Aug 21, 2013, 09:37 PM |
| SIMPSON TODD E | Chief Financial Officer | Aug 19, 2013 | Sale | $40.91 | 3,328 | 136,148 | 110,629 | Aug 21, 2013, 09:29 PM |
| DOBMEIER ERIC | Chief Operating Officer | Aug 19, 2013 | Sale | $40.91 | 3,328 | 136,148 | 109,620 | Aug 21, 2013, 09:26 PM |
| HIMES VAUGHN B | EVP, Tech. Ops. & Proc. Sci. | Aug 19, 2013 | Sale | $40.91 | 1,736 | 71,020 | 31,907 | Aug 21, 2013, 09:21 PM |
| BOERNER CHRISTOPHER S. | SVP, Commercial | Aug 19, 2013 | Sale | $40.91 | 226 | 9,246 | 33,527 | Aug 21, 2013, 09:18 PM |
| SIEGALL CLAY B | President and CEO | Aug 01, 2013 | Option Exercise | $10.33 | 2,000 | 20,660 | 1,079,211 | Aug 02, 2013, 05:49 PM |
| SIEGALL CLAY B | President and CEO | Aug 01, 2013 | Sale | $40.03 | 2,000 | 80,063 | 1,077,211 | Aug 02, 2013, 05:49 PM |
| SIMPSON TODD E | Chief Financial Officer | Jul 12, 2013 | Option Exercise | $14.12 | 47,527 | 671,238 | 143,123 | Jul 15, 2013, 07:58 PM |
| SIMPSON TODD E | Chief Financial Officer | Jul 11, 2013 | Option Exercise | $12.01 | 45,000 | 540,238 | 157,471 | Jul 15, 2013, 07:58 PM |
| SIMPSON TODD E | Chief Financial Officer | Jul 11, 2013 | Sale | $36.94 | 45,000 | 1,662,300 | 113,957 | Jul 15, 2013, 07:58 PM |
| SIMPSON TODD E | Chief Financial Officer | Jul 12, 2013 | Sale | $37.94 | 47,527 | 1,803,174 | 113,957 | Jul 15, 2013, 07:58 PM |
| SIEGALL CLAY B | President and CEO | Jul 01, 2013 | Option Exercise | $10.33 | 2,000 | 20,660 | 1,079,211 | Jul 02, 2013, 04:47 PM |
| SIEGALL CLAY B | President and CEO | Jul 01, 2013 | Sale | $32.59 | 2,000 | 65,186 | 1,077,211 | Jul 02, 2013, 04:47 PM |
| AKKARAJU SRINIVAS | Director | Jun 14, 2013 | Option Exercise | $8.38 | 5,000 | 41,900 | 18,905 | Jun 17, 2013, 07:28 PM |
| AKKARAJU SRINIVAS | Director | Jun 14, 2013 | Sale | $32.75 | 5,000 | 163,750 | 13,905 | Jun 17, 2013, 07:28 PM |
| HIMES VAUGHN B | EVP, Tech. Ops. & Proc. Sci. | Jun 13, 2013 | Option Exercise | $9.23 | 10,000 | 92,300 | 43,643 | Jun 17, 2013, 07:26 PM |
| HIMES VAUGHN B | EVP, Tech. Ops. & Proc. Sci. | Jun 13, 2013 | Sale | $32.11 | 10,000 | 321,100 | 33,643 | Jun 17, 2013, 07:26 PM |
| SIEGALL CLAY B | President and CEO | Jun 03, 2013 | Option Exercise | $10.33 | 2,000 | 20,660 | 1,079,211 | Jun 05, 2013, 04:48 PM |
| SIEGALL CLAY B | President and CEO | Jun 03, 2013 | Sale | $33.88 | 2,000 | 67,762 | 1,077,211 | Jun 05, 2013, 04:48 PM |
| AKKARAJU SRINIVAS | Director | May 10, 2013 | Option Exercise | $12.76 | 17,500 | 223,300 | 27,905 | May 14, 2013, 09:30 AM |
| AKKARAJU SRINIVAS | Director | May 10, 2013 | Sale | $37.17 | 17,500 | 650,430 | 10,405 | May 14, 2013, 09:30 AM |
| SIEGALL CLAY B | President and CEO | May 01, 2013 | Option Exercise | $10.33 | 2,000 | 20,660 | 1,079,211 | May 03, 2013, 06:39 PM |
| SIEGALL CLAY B | President and CEO | May 01, 2013 | Sale | $36.58 | 2,000 | 73,153 | 1,077,211 | May 03, 2013, 06:39 PM |
| SIEGALL CLAY B | President and CEO | Apr 01, 2013 | Option Exercise | $10.33 | 2,000 | 20,660 | 1,079,211 | Apr 03, 2013, 06:31 PM |
| SIEGALL CLAY B | President and CEO | Apr 01, 2013 | Sale | $35.53 | 2,000 | 71,062 | 1,077,211 | Apr 03, 2013, 06:31 PM |
| BOERNER CHRISTOPHER S. | SVP, Commercial | Mar 15, 2013 | Option Exercise | $15.10 | 8,500 | 128,350 | 42,253 | Mar 19, 2013, 07:23 PM |
| BOERNER CHRISTOPHER S. | SVP, Commercial | Mar 15, 2013 | Sale | $33.61 | 8,500 | 285,663 | 33,753 | Mar 19, 2013, 07:23 PM |
| DOBMEIER ERIC | Chief Operating Officer | Mar 11, 2013 | Option Exercise | $12.11 | 50,000 | 605,671 | 158,392 | Mar 12, 2013, 07:10 PM |
| DOBMEIER ERIC | Chief Operating Officer | Mar 11, 2013 | Sale | $31.16 | 60,000 | 1,869,471 | 122,948 | Mar 12, 2013, 07:10 PM |
| SIMPSON TODD E | Chief Financial Officer | Mar 07, 2013 | Option Exercise | $12.12 | 20,176 | 244,610 | 133,451 | Mar 08, 2013, 07:13 PM |
| SIMPSON TODD E | Chief Financial Officer | Mar 07, 2013 | Sale | $30.75 | 49,718 | 1,528,706 | 113,957 | Mar 08, 2013, 07:13 PM |
| DOBMEIER ERIC | Chief Operating Officer | Mar 05, 2013 | Option Exercise | $12.16 | 12,567 | 152,815 | 135,515 | Mar 06, 2013, 07:16 PM |
| DOBMEIER ERIC | Chief Operating Officer | Mar 04, 2013 | Option Exercise | $12.16 | 37,433 | 455,185 | 160,381 | Mar 06, 2013, 07:16 PM |
| DOBMEIER ERIC | Chief Operating Officer | Mar 06, 2013 | Option Exercise | $12.00 | 50,000 | 600,000 | 172,948 | Mar 06, 2013, 07:16 PM |
| DOBMEIER ERIC | Chief Operating Officer | Mar 04, 2013 | Sale | $28.95 | 37,433 | 1,083,685 | 122,948 | Mar 06, 2013, 07:16 PM |
| DOBMEIER ERIC | Chief Operating Officer | Mar 06, 2013 | Sale | $30.42 | 50,000 | 1,520,955 | 122,948 | Mar 06, 2013, 07:16 PM |
| DOBMEIER ERIC | Chief Operating Officer | Mar 05, 2013 | Sale | $28.95 | 12,567 | 363,815 | 122,948 | Mar 06, 2013, 07:16 PM |
| SIEGALL CLAY B | President and CEO | Mar 01, 2013 | Option Exercise | $10.33 | 2,000 | 20,660 | 1,172,961 | Mar 05, 2013, 07:07 PM |
| SIEGALL CLAY B | President and CEO | Mar 05, 2013 | Sale | $28.87 | 68,750 | 1,984,950 | 1,077,211 | Mar 05, 2013, 07:07 PM |
| SIEGALL CLAY B | President and CEO | Mar 01, 2013 | Sale | $28.30 | 27,000 | 764,067 | 1,170,961 | Mar 05, 2013, 07:07 PM |
| GRYSKA DAVID W | Director | Feb 26, 2013 | Option Exercise | $6.69 | 10,000 | 66,900 | 18,500 | Feb 27, 2013, 04:40 PM |
| GRYSKA DAVID W | Director | Feb 25, 2013 | Sale | $27.17 | 10,000 | 271,700 | 8,500 | Feb 27, 2013, 04:40 PM |
| SIEGALL CLAY B | President and CEO | Feb 01, 2013 | Option Exercise | $10.33 | 2,000 | 20,660 | 1,172,961 | Feb 05, 2013, 07:32 PM |
| SIEGALL CLAY B | President and CEO | Feb 01, 2013 | Sale | $29.61 | 2,000 | 59,216 | 1,170,961 | Feb 05, 2013, 07:32 PM |
| Reynolds Thomas C | Chief Medical Officer | Jan 25, 2013 | Option Exercise | $15.46 | 2,083 | 32,203 | 59,684 | Jan 29, 2013, 08:16 PM |
| Reynolds Thomas C | Chief Medical Officer | Jan 28, 2013 | Option Exercise | $12.08 | 5,207 | 62,900 | 60,205 | Jan 29, 2013, 08:16 PM |
| Reynolds Thomas C | Chief Medical Officer | Jan 28, 2013 | Sale | $30.19 | 5,207 | 157,188 | 57,601 | Jan 29, 2013, 08:16 PM |
| Reynolds Thomas C | Chief Medical Officer | Jan 25, 2013 | Sale | $29.84 | 2,083 | 62,155 | 57,601 | Jan 29, 2013, 08:16 PM |
| Reynolds Thomas C | Chief Medical Officer | Jan 15, 2013 | Option Exercise | $11.62 | 125,079 | 1,452,804 | 93,094 | Jan 17, 2013, 08:12 PM |
| Reynolds Thomas C | Chief Medical Officer | Jan 15, 2013 | Sale | $28.00 | 125,079 | 3,502,526 | 57,601 | Jan 17, 2013, 08:12 PM |
| DOBMEIER ERIC | Chief Operating Officer | Jan 04, 2013 | Option Exercise | $11.09 | 60,000 | 665,400 | 173,829 | Jan 04, 2013, 06:49 PM |
| DOBMEIER ERIC | Chief Operating Officer | Jan 04, 2013 | Sale | $24.95 | 50,983 | 1,272,026 | 122,846 | Jan 04, 2013, 06:49 PM |
| SIEGALL CLAY B | President and CEO | Jan 04, 2013 | Option Exercise | $10.33 | 2,000 | 20,660 | 1,172,961 | Jan 04, 2013, 06:46 PM |
| SIEGALL CLAY B | President and CEO | Jan 02, 2013 | Option Exercise | $3.30 | 6,249 | 20,622 | 1,177,210 | Jan 04, 2013, 06:46 PM |
| SIEGALL CLAY B | President and CEO | Jan 02, 2013 | Sale | $23.83 | 6,249 | 148,939 | 1,170,961 | Jan 04, 2013, 06:46 PM |
| SIEGALL CLAY B | President and CEO | Jan 04, 2013 | Sale | $25.05 | 2,000 | 50,104 | 1,170,961 | Jan 04, 2013, 06:46 PM |
| DOBMEIER ERIC | Chief Operating Officer | Dec 17, 2012 | Option Exercise | $10.92 | 62,418 | 681,573 | 163,829 | Dec 19, 2012, 04:50 PM |
| DOBMEIER ERIC | Chief Operating Officer | Dec 17, 2012 | Sale | $23.70 | 50,000 | 1,184,955 | 113,829 | Dec 19, 2012, 04:50 PM |
| Reynolds Thomas C | Chief Medical Officer | Dec 07, 2012 | Option Exercise | $10.29 | 30,000 | 308,700 | 87,601 | Dec 10, 2012, 06:17 PM |
| Reynolds Thomas C | Chief Medical Officer | Dec 06, 2012 | Option Exercise | $12.16 | 30,000 | 364,800 | 87,601 | Dec 10, 2012, 06:17 PM |
| Reynolds Thomas C | Chief Medical Officer | Dec 10, 2012 | Option Exercise | $10.94 | 6,588 | 72,061 | 62,939 | Dec 10, 2012, 06:17 PM |
| Reynolds Thomas C | Chief Medical Officer | Dec 07, 2012 | Sale | $25.77 | 30,000 | 773,082 | 57,601 | Dec 10, 2012, 06:17 PM |
| Reynolds Thomas C | Chief Medical Officer | Dec 06, 2012 | Sale | $25.77 | 30,000 | 772,983 | 57,601 | Dec 10, 2012, 06:17 PM |
| Reynolds Thomas C | Chief Medical Officer | Dec 10, 2012 | Sale | $25.75 | 6,588 | 169,641 | 57,601 | Dec 10, 2012, 06:17 PM |
| LIPPMAN MARC E | Director | Dec 05, 2012 | Option Exercise | $6.83 | 67,500 | 461,325 | 132,950 | Dec 07, 2012, 07:28 PM |
| LIPPMAN MARC E | Director | Dec 05, 2012 | Sale | $25.54 | 67,500 | 1,723,950 | 117,950 | Dec 07, 2012, 07:28 PM |
| Reynolds Thomas C | Chief Medical Officer | Dec 05, 2012 | Option Exercise | $12.16 | 10,000 | 121,600 | 67,601 | Dec 06, 2012, 07:30 PM |
| Reynolds Thomas C | Chief Medical Officer | Dec 04, 2012 | Option Exercise | $12.11 | 30,000 | 363,200 | 67,601 | Dec 06, 2012, 07:30 PM |
| Reynolds Thomas C | Chief Medical Officer | Dec 05, 2012 | Sale | $25.60 | 10,000 | 256,000 | 57,601 | Dec 06, 2012, 07:30 PM |
| Reynolds Thomas C | Chief Medical Officer | Dec 04, 2012 | Sale | $25.58 | 30,000 | 767,500 | 57,601 | Dec 06, 2012, 07:30 PM |
| WELCH DANIEL G | Director | Dec 03, 2012 | Option Exercise | $8.38 | 3,119 | 26,137 | 6,119 | Dec 04, 2012, 07:44 PM |
| SIEGALL CLAY B | President and CEO | Dec 03, 2012 | Option Exercise | $3.30 | 8,250 | 27,225 | 1,179,211 | Dec 04, 2012, 07:40 PM |
| SIEGALL CLAY B | President and CEO | Dec 03, 2012 | Sale | $25.19 | 8,250 | 207,777 | 1,170,961 | Dec 04, 2012, 07:40 PM |
| Reynolds Thomas C | Chief Medical Officer | Dec 03, 2012 | Option Exercise | $12.16 | 10,000 | 121,600 | 67,601 | Dec 03, 2012, 07:48 PM |
| Reynolds Thomas C | Chief Medical Officer | Nov 30, 2012 | Option Exercise | $12.01 | 10,000 | 120,084 | 67,078 | Dec 03, 2012, 07:48 PM |
| Reynolds Thomas C | Chief Medical Officer | Nov 29, 2012 | Option Exercise | $12.00 | 20,000 | 240,000 | 67,601 | Dec 03, 2012, 07:48 PM |
| Reynolds Thomas C | Chief Medical Officer | Dec 03, 2012 | Sale | $25.45 | 10,000 | 254,500 | 57,601 | Dec 03, 2012, 07:48 PM |
| Reynolds Thomas C | Chief Medical Officer | Nov 30, 2012 | Sale | $25.50 | 10,000 | 255,000 | 57,601 | Dec 03, 2012, 07:48 PM |
| Reynolds Thomas C | Chief Medical Officer | Nov 29, 2012 | Sale | $25.35 | 20,000 | 507,085 | 57,601 | Dec 03, 2012, 07:48 PM |
| Reynolds Thomas C | Chief Medical Officer | Nov 26, 2012 | Option Exercise | $12.00 | 3,000 | 36,000 | 60,601 | Nov 26, 2012, 06:58 PM |
| Reynolds Thomas C | Chief Medical Officer | Nov 23, 2012 | Option Exercise | $12.00 | 17,000 | 204,000 | 67,601 | Nov 26, 2012, 06:58 PM |
| Reynolds Thomas C | Chief Medical Officer | Nov 21, 2012 | Option Exercise | $15.46 | 10,000 | 154,600 | 67,601 | Nov 26, 2012, 06:58 PM |
| Reynolds Thomas C | Chief Medical Officer | Nov 23, 2012 | Sale | $25.36 | 17,000 | 431,100 | 57,601 | Nov 26, 2012, 06:58 PM |
| Reynolds Thomas C | Chief Medical Officer | Nov 21, 2012 | Sale | $25.25 | 10,000 | 252,500 | 57,601 | Nov 26, 2012, 06:58 PM |
| Reynolds Thomas C | Chief Medical Officer | Nov 26, 2012 | Sale | $25.50 | 3,000 | 76,500 | 57,601 | Nov 26, 2012, 06:58 PM |
| Reynolds Thomas C | Chief Medical Officer | Nov 20, 2012 | Option Exercise | $15.17 | 10,000 | 151,714 | 66,767 | Nov 20, 2012, 07:23 PM |
| Reynolds Thomas C | Chief Medical Officer | Nov 19, 2012 | Option Exercise | $15.46 | 10,000 | 154,600 | 67,601 | Nov 20, 2012, 07:23 PM |
| Reynolds Thomas C | Chief Medical Officer | Nov 19, 2012 | Sale | $24.90 | 10,000 | 249,002 | 57,601 | Nov 20, 2012, 07:23 PM |
| Reynolds Thomas C | Chief Medical Officer | Nov 20, 2012 | Sale | $25.00 | 10,000 | 250,000 | 57,601 | Nov 20, 2012, 07:23 PM |
| DOBMEIER ERIC | Chief Operating Officer | Nov 13, 2012 | Option Exercise | $10.29 | 24,811 | 255,305 | 126,222 | Nov 15, 2012, 07:16 PM |
| DOBMEIER ERIC | Chief Operating Officer | Nov 13, 2012 | Sale | $23.59 | 27,327 | 644,724 | 101,411 | Nov 15, 2012, 07:16 PM |
| SIMPSON TODD E | Chief Financial Officer | Nov 08, 2012 | Option Exercise | $5.20 | 72,737 | 378,412 | 143,499 | Nov 09, 2012, 06:03 PM |
| DOBMEIER ERIC | Chief Operating Officer | Nov 08, 2012 | Option Exercise | $6.45 | 34,575 | 223,107 | 103,927 | Nov 09, 2012, 06:01 PM |
| SIEGALL CLAY B | President and CEO | Nov 01, 2012 | Option Exercise | $5.00 | 8,250 | 41,285 | 1,177,211 | Nov 02, 2012, 05:23 PM |
| SIEGALL CLAY B | President and CEO | Nov 01, 2012 | Sale | $25.51 | 8,250 | 210,476 | 1,170,961 | Nov 02, 2012, 05:23 PM |
| DOBMEIER ERIC | Chief Operating Officer | Oct 15, 2012 | Option Exercise | $10.29 | 25,000 | 257,250 | 94,352 | Oct 16, 2012, 08:05 PM |
| DOBMEIER ERIC | Chief Operating Officer | Oct 15, 2012 | Sale | $25.01 | 25,000 | 625,295 | 69,352 | Oct 16, 2012, 08:05 PM |
| SIEGALL CLAY B | President and CEO | Oct 01, 2012 | Option Exercise | $5.00 | 8,250 | 41,285 | 1,177,211 | Oct 02, 2012, 08:23 PM |
| SIEGALL CLAY B | President and CEO | Oct 01, 2012 | Sale | $26.59 | 8,250 | 219,344 | 1,170,961 | Oct 02, 2012, 08:23 PM |
| HIMES VAUGHN B | EVP, Tech. Ops. & Proc. Sci. | Sep 10, 2012 | Option Exercise | $9.23 | 10,000 | 92,300 | 43,643 | Sep 12, 2012, 06:26 PM |
| HIMES VAUGHN B | EVP, Tech. Ops. & Proc. Sci. | Sep 10, 2012 | Sale | $28.79 | 10,000 | 287,900 | 33,643 | Sep 12, 2012, 06:26 PM |
| Reynolds Thomas C | Chief Medical Officer | Sep 06, 2012 | Option Exercise | $8.24 | 48,540 | 399,970 | 106,141 | Sep 10, 2012, 08:02 PM |
| Reynolds Thomas C | Chief Medical Officer | Sep 06, 2012 | Sale | $29.75 | 48,540 | 1,444,065 | 57,601 | Sep 10, 2012, 08:02 PM |
| SIMPSON TODD E | Chief Financial Officer | Sep 05, 2012 | Option Exercise | $11.16 | 45,000 | 502,073 | 112,937 | Sep 07, 2012, 07:40 PM |
| SIMPSON TODD E | Chief Financial Officer | Sep 06, 2012 | Option Exercise | $12.16 | 50,000 | 608,000 | 120,762 | Sep 07, 2012, 07:40 PM |
| SIMPSON TODD E | Chief Financial Officer | Sep 05, 2012 | Sale | $27.97 | 45,000 | 1,258,650 | 70,762 | Sep 07, 2012, 07:40 PM |
| SIMPSON TODD E | Chief Financial Officer | Sep 06, 2012 | Sale | $28.97 | 50,000 | 1,448,500 | 70,762 | Sep 07, 2012, 07:40 PM |
| SIEGALL CLAY B | President and CEO | Sep 04, 2012 | Option Exercise | $5.00 | 8,250 | 41,285 | 1,177,211 | Sep 06, 2012, 07:51 PM |
| SIEGALL CLAY B | President and CEO | Sep 04, 2012 | Sale | $26.54 | 8,250 | 218,958 | 1,170,961 | Sep 06, 2012, 07:51 PM |
| SIMPSON TODD E | Chief Financial Officer | Aug 24, 2012 | Option Exercise | $10.29 | 14,000 | 144,060 | 84,762 | Aug 27, 2012, 07:55 PM |
| SIMPSON TODD E | Chief Financial Officer | Aug 27, 2012 | Option Exercise | $10.63 | 31,000 | 329,491 | 88,636 | Aug 27, 2012, 07:55 PM |
| SIMPSON TODD E | Chief Financial Officer | Aug 27, 2012 | Sale | $26.97 | 31,000 | 836,070 | 70,762 | Aug 27, 2012, 07:55 PM |
| SIMPSON TODD E | Chief Financial Officer | Aug 24, 2012 | Sale | $26.97 | 14,000 | 377,580 | 70,762 | Aug 27, 2012, 07:55 PM |
| BERGER FRANKLIN M | Director | Aug 23, 2012 | Option Exercise | $10.14 | 20,000 | 202,800 | 183,720 | Aug 27, 2012, 07:51 PM |
| SIMPSON TODD E | Chief Financial Officer | Aug 16, 2012 | Option Exercise | $10.29 | 40,000 | 411,600 | 90,762 | Aug 20, 2012, 07:28 PM |
| SIMPSON TODD E | Chief Financial Officer | Aug 16, 2012 | Sale | $25.97 | 40,000 | 1,038,800 | 50,762 | Aug 20, 2012, 07:28 PM |
| DOBMEIER ERIC | Chief Operating Officer | Aug 13, 2012 | Sale | $24.01 | 25,000 | 600,290 | 43,352 | Aug 15, 2012, 04:30 PM |
| GRYSKA DAVID W | Director | Aug 10, 2012 | Option Exercise | $5.00 | 7,500 | 37,500 | 19,000 | Aug 14, 2012, 04:31 PM |
| SIEGALL CLAY B | President and CEO | Aug 02, 2012 | Option Exercise | $3.30 | 458 | 1,511 | 1,097,169 | Aug 03, 2012, 05:06 PM |
| SIEGALL CLAY B | President and CEO | Aug 01, 2012 | Option Exercise | $5.10 | 7,792 | 39,774 | 1,102,503 | Aug 03, 2012, 05:06 PM |
| SIEGALL CLAY B | President and CEO | Aug 02, 2012 | Sale | $25.22 | 458 | 11,550 | 1,096,711 | Aug 03, 2012, 05:06 PM |
| SIEGALL CLAY B | President and CEO | Aug 01, 2012 | Sale | $26.04 | 7,792 | 202,911 | 1,096,711 | Aug 03, 2012, 05:06 PM |
| WELCH DANIEL G | Director | Jul 27, 2012 | Option Exercise | $19.02 | 3,000 | 57,060 | 3,000 | Jul 31, 2012, 06:13 PM |
| SIEGALL CLAY B | President & CEO | Jul 02, 2012 | Option Exercise | $5.00 | 8,250 | 41,285 | 1,102,961 | Jul 05, 2012, 04:59 PM |
| SIEGALL CLAY B | President & CEO | Jul 02, 2012 | Sale | $25.36 | 8,250 | 209,201 | 1,096,711 | Jul 05, 2012, 04:59 PM |
| DOBMEIER ERIC | Chief Operating Officer | Jun 18, 2012 | Option Exercise | $10.29 | 25,000 | 257,250 | 93,073 | Jun 20, 2012, 07:26 PM |
| DOBMEIER ERIC | Chief Operating Officer | Jun 18, 2012 | Sale | $25.36 | 25,000 | 634,000 | 68,073 | Jun 20, 2012, 07:26 PM |
| ROSENBERG MORRIS | EVP, Process Sciences | Jun 12, 2012 | Option Exercise | $10.29 | 10,000 | 102,900 | 27,643 | Jun 14, 2012, 07:51 PM |
| ROSENBERG MORRIS | EVP, Process Sciences | Jun 12, 2012 | Sale | $24.00 | 10,000 | 240,000 | 17,643 | Jun 14, 2012, 07:51 PM |
| SIMPSON TODD E | Chief Financial Officer | Jun 14, 2012 | Option Exercise | $5.37 | 50,000 | 268,421 | 81,179 | Jun 14, 2012, 07:49 PM |
| SIMPSON TODD E | Chief Financial Officer | Jun 12, 2012 | Option Exercise | $5.20 | 45,000 | 234,000 | 95,762 | Jun 14, 2012, 07:49 PM |
| SIMPSON TODD E | Chief Financial Officer | Jun 14, 2012 | Sale | $24.97 | 50,000 | 1,248,500 | 50,762 | Jun 14, 2012, 07:49 PM |
| SIMPSON TODD E | Chief Financial Officer | Jun 12, 2012 | Sale | $23.97 | 45,000 | 1,078,785 | 50,762 | Jun 14, 2012, 07:49 PM |
| SIMPSON TODD E | Chief Financial Officer | Jun 08, 2012 | Option Exercise | $5.20 | 35,000 | 182,000 | 85,762 | Jun 08, 2012, 07:45 PM |
| SIMPSON TODD E | Chief Financial Officer | Jun 08, 2012 | Sale | $22.97 | 35,000 | 803,950 | 50,762 | Jun 08, 2012, 07:45 PM |
| ROSENBERG MORRIS | EVP, Process Sciences | Jun 07, 2012 | Option Exercise | $10.29 | 13,566 | 139,594 | 31,209 | Jun 08, 2012, 07:43 PM |
| ROSENBERG MORRIS | EVP, Process Sciences | Jun 07, 2012 | Sale | $22.50 | 13,566 | 305,235 | 17,643 | Jun 08, 2012, 07:43 PM |
| GRYSKA DAVID W | Director | Jun 05, 2012 | Sale | $19.75 | 8,000 | 158,000 | 11,500 | Jun 06, 2012, 05:52 PM |
| ROSENBERG MORRIS | EVP, Process Sciences | May 16, 2012 | Option Exercise | $4.45 | 200 | 890 | 17,843 | May 18, 2012, 07:00 PM |
| ROSENBERG MORRIS | EVP, Process Sciences | May 18, 2012 | Option Exercise | $4.45 | 64,800 | 288,360 | 65,419 | May 18, 2012, 07:00 PM |
| ROSENBERG MORRIS | EVP, Process Sciences | May 16, 2012 | Sale | $20.80 | 200 | 4,160 | 17,643 | May 18, 2012, 07:00 PM |
| ROSENBERG MORRIS | EVP, Process Sciences | May 18, 2012 | Sale | $21.54 | 64,800 | 1,395,616 | 17,643 | May 18, 2012, 07:00 PM |
| Reynolds Thomas C | Chief Medical Officer | May 15, 2012 | Option Exercise | $8.24 | 949 | 7,820 | 32,022 | May 17, 2012, 08:38 PM |
| Reynolds Thomas C | Chief Medical Officer | May 15, 2012 | Sale | $19.75 | 949 | 18,743 | 31,073 | May 17, 2012, 08:38 PM |
| Reynolds Thomas C | Chief Medical Officer | Apr 25, 2012 | Option Exercise | $8.24 | 40,000 | 329,600 | 71,073 | Apr 26, 2012, 07:44 PM |
| Reynolds Thomas C | Chief Medical Officer | Apr 25, 2012 | Sale | $19.75 | 40,000 | 790,000 | 31,073 | Apr 26, 2012, 07:44 PM |
| DOBMEIER ERIC | Chief Operating Officer | Apr 25, 2012 | Option Exercise | $10.24 | 25,000 | 255,957 | 82,438 | Apr 26, 2012, 07:39 PM |
| DOBMEIER ERIC | Chief Operating Officer | Apr 25, 2012 | Sale | $19.95 | 25,000 | 498,750 | 68,073 | Apr 26, 2012, 07:39 PM |
| ROSENBERG MORRIS | EVP, Process Sciences | Apr 20, 2012 | Option Exercise | $5.63 | 38,281 | 215,522 | 55,924 | Apr 24, 2012, 07:30 PM |
| ROSENBERG MORRIS | EVP, Process Sciences | Apr 20, 2012 | Sale | $19.51 | 38,281 | 746,862 | 17,643 | Apr 24, 2012, 07:30 PM |
| ROSENBERG MORRIS | EVP, Process Sciences | Apr 17, 2012 | Option Exercise | $5.83 | 44,219 | 257,653 | 46,080 | Apr 19, 2012, 04:01 PM |
| ROSENBERG MORRIS | EVP, Process Sciences | Apr 17, 2012 | Sale | $18.88 | 44,219 | 834,855 | 17,643 | Apr 19, 2012, 04:01 PM |
| Reynolds Thomas C | Chief Medical Officer | Mar 22, 2012 | Option Exercise | $8.24 | 40,000 | 329,600 | 71,073 | Mar 23, 2012, 05:25 PM |
| Reynolds Thomas C | Chief Medical Officer | Mar 22, 2012 | Sale | $19.78 | 40,000 | 791,100 | 31,073 | Mar 23, 2012, 05:25 PM |
| LIPPMAN MARC E | Director | Mar 19, 2012 | Option Exercise | $4.97 | 7,500 | 37,275 | 117,950 | Mar 20, 2012, 07:21 PM |
| Reynolds Thomas C | Chief Medical Officer | Mar 19, 2012 | Option Exercise | $8.24 | 37,700 | 310,648 | 68,773 | Mar 20, 2012, 07:19 PM |
| Reynolds Thomas C | Chief Medical Officer | Mar 16, 2012 | Option Exercise | $8.24 | 2,300 | 18,952 | 33,373 | Mar 20, 2012, 07:19 PM |
| Reynolds Thomas C | Chief Medical Officer | Mar 16, 2012 | Sale | $19.75 | 2,300 | 45,425 | 31,073 | Mar 20, 2012, 07:19 PM |
| Reynolds Thomas C | Chief Medical Officer | Mar 19, 2012 | Sale | $19.75 | 37,700 | 744,575 | 31,073 | Mar 20, 2012, 07:19 PM |
| ROSENBERG MORRIS | EVP, Process Sciences | Mar 13, 2012 | Option Exercise | $6.72 | 69,626 | 468,168 | 54,204 | Mar 15, 2012, 04:37 PM |
| ROSENBERG MORRIS | EVP, Process Sciences | Mar 13, 2012 | Sale | $18.59 | 69,626 | 1,294,173 | 17,643 | Mar 15, 2012, 04:37 PM |
| DOBMEIER ERIC | Chief Operating Officer | Feb 28, 2012 | Sale | $18.53 | 4,000 | 74,114 | 68,073 | Mar 01, 2012, 05:17 PM |
| DOBMEIER ERIC | Chief Operating Officer | Feb 28, 2012 | Option Exercise | $10.25 | 46,000 | 471,570 | 99,844 | Feb 29, 2012, 06:32 PM |
| DOBMEIER ERIC | Chief Operating Officer | Feb 28, 2012 | Sale | $18.52 | 46,000 | 851,938 | 72,073 | Feb 29, 2012, 06:32 PM |
| Reynolds Thomas C | Chief Medical Officer | Jan 27, 2012 | Option Exercise | $8.24 | 40,000 | 329,600 | 70,169 | Jan 30, 2012, 07:33 PM |
| Reynolds Thomas C | Chief Medical Officer | Jan 27, 2012 | Sale | $19.75 | 40,000 | 790,000 | 30,169 | Jan 30, 2012, 07:33 PM |
| SIEGALL CLAY B | President and CEO | Jan 03, 2012 | Option Exercise | $6.34 | 15,000 | 95,100 | 1,060,055 | Jan 05, 2012, 08:27 PM |
| SIEGALL CLAY B | President and CEO | Jan 03, 2012 | Sale | $16.73 | 15,000 | 250,959 | 1,045,055 | Jan 05, 2012, 08:27 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Dec 30, 2011 | Option Exercise | $6.25 | 355,143 | 2,219,644 | 15,131,223 | Jan 04, 2012, 07:25 PM |
| Baker Bros. Capital (GP), LLC | Director | Dec 30, 2011 | Option Exercise | $6.25 | 68,006 | 425,038 | 539,130 | Jan 04, 2012, 07:24 PM |
| Baker Biotech Capital (GP), LLC | Director | Dec 30, 2011 | Option Exercise | $6.25 | 339,788 | 2,123,675 | 4,966,001 | Jan 04, 2012, 07:24 PM |
| Baker / Tisch Capital (GP), LLC | Director | Dec 30, 2011 | Option Exercise | $6.25 | 49,563 | 309,769 | 450,461 | Jan 04, 2012, 07:23 PM |
| DOBMEIER ERIC | Chief Operating Officer | Dec 22, 2011 | Option Exercise | $4.45 | 10,000 | 44,500 | 71,843 | Dec 22, 2011, 05:29 PM |
| LIPPMAN MARC E | Director | Dec 14, 2011 | Option Exercise | $6.40 | 6,875 | 44,000 | 110,450 | Dec 16, 2011, 08:28 PM |
| GRYSKA DAVID W | Director | Dec 15, 2011 | Option Exercise | $5.00 | 4,500 | 22,500 | 19,500 | Dec 16, 2011, 08:24 PM |
| GRYSKA DAVID W | Director | Dec 09, 2011 | Sale | $18.09 | 10,000 | 180,917 | 15,000 | Dec 13, 2011, 06:53 PM |
| SIEGALL CLAY B | President and CEO | Dec 01, 2011 | Option Exercise | $6.34 | 15,000 | 95,100 | 1,060,055 | Dec 02, 2011, 06:35 PM |
| SIEGALL CLAY B | President and CEO | Dec 01, 2011 | Sale | $15.97 | 15,000 | 239,596 | 1,045,055 | Dec 02, 2011, 06:35 PM |
| DOBMEIER ERIC | Chief Operating Officer | Nov 09, 2011 | Option Exercise | $5.25 | 2,516 | 13,209 | 61,843 | Nov 10, 2011, 07:52 PM |
| SIEGALL CLAY B | President and CEO | Nov 01, 2011 | Option Exercise | $6.34 | 15,000 | 95,100 | 1,060,055 | Nov 03, 2011, 08:08 PM |
| SIEGALL CLAY B | President and CEO | Nov 01, 2011 | Sale | $21.89 | 15,000 | 328,413 | 1,045,055 | Nov 03, 2011, 08:08 PM |
| DOBMEIER ERIC | Chief Operating Officer | Oct 27, 2011 | Option Exercise | $5.87 | 20,918 | 122,725 | 70,162 | Oct 27, 2011, 07:58 PM |
| DOBMEIER ERIC | Chief Operating Officer | Oct 27, 2011 | Sale | $21.95 | 20,918 | 459,150 | 59,327 | Oct 27, 2011, 07:58 PM |
| DOBMEIER ERIC | Chief Operating Officer | Oct 20, 2011 | Option Exercise | $6.74 | 20,461 | 137,907 | 79,788 | Oct 21, 2011, 06:45 PM |
| DOBMEIER ERIC | Chief Operating Officer | Oct 20, 2011 | Sale | $20.58 | 20,461 | 421,024 | 59,327 | Oct 21, 2011, 06:45 PM |
| SIMPSON TODD E | Chief Financial Officer | Oct 07, 2011 | Option Exercise | $5.20 | 24,350 | 126,620 | 73,592 | Oct 07, 2011, 07:14 PM |
| SIMPSON TODD E | Chief Financial Officer | Oct 07, 2011 | Sale | $21.97 | 24,350 | 534,969 | 49,242 | Oct 07, 2011, 07:14 PM |
| SIEGALL CLAY B | President and CEO | Oct 04, 2011 | Option Exercise | $6.34 | 15,000 | 95,100 | 1,060,055 | Oct 06, 2011, 07:19 PM |
| SIEGALL CLAY B | President and CEO | Oct 04, 2011 | Sale | $20.15 | 15,000 | 302,283 | 1,045,055 | Oct 06, 2011, 07:19 PM |
| SIEGALL CLAY B | President and CEO | Sep 21, 2011 | Option Exercise | $6.34 | 24,400 | 154,696 | 1,069,455 | Sep 21, 2011, 08:49 PM |
| SIEGALL CLAY B | President and CEO | Sep 20, 2011 | Option Exercise | $6.34 | 5,600 | 35,504 | 1,050,655 | Sep 21, 2011, 08:49 PM |
| SIEGALL CLAY B | President and CEO | Sep 21, 2011 | Sale | $20.15 | 24,400 | 491,711 | 1,045,055 | Sep 21, 2011, 08:49 PM |
| SIEGALL CLAY B | President and CEO | Sep 20, 2011 | Sale | $20.00 | 5,600 | 112,007 | 1,045,055 | Sep 21, 2011, 08:49 PM |
| MCLAUGHLIN JOHN PETER | Director | Sep 09, 2011 | Option Exercise | $9.82 | 25,000 | 245,500 | 25,000 | Sep 13, 2011, 05:04 PM |
| 14159 capital (GP), LLC | Director | Sep 06, 2011 | Buy | $17.08 | 1,773 | 30,285 | 323,148 | Sep 08, 2011, 05:13 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Sep 06, 2011 | Buy | $17.08 | 129,187 | 2,206,641 | 14,776,080 | Sep 08, 2011, 05:12 PM |
| SIEGALL CLAY B | President and CEO | Sep 02, 2011 | Option Exercise | $3.30 | 16,251 | 53,628 | 1,045,055 | Sep 06, 2011, 08:40 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Aug 25, 2011 | Buy | $15.49 | 984,850 | 15,253,844 | 14,646,893 | Aug 25, 2011, 05:37 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Aug 24, 2011 | Buy | $14.98 | 9,576 | 143,432 | 13,662,043 | Aug 25, 2011, 05:37 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Aug 23, 2011 | Buy | $14.79 | 171,009 | 2,528,388 | 13,652,467 | Aug 25, 2011, 05:37 PM |
| 14159 capital (GP), LLC | Director | Aug 24, 2011 | Buy | $14.98 | 147 | 2,202 | 306,225 | Aug 25, 2011, 05:36 PM |
| 14159 capital (GP), LLC | Director | Aug 23, 2011 | Buy | $14.79 | 2,629 | 38,870 | 306,078 | Aug 25, 2011, 05:36 PM |
| 14159 capital (GP), LLC | Director | Aug 25, 2011 | Buy | $15.49 | 15,150 | 234,651 | 321,375 | Aug 25, 2011, 05:36 PM |
| Reynolds Thomas C | Chief Medical Officer | Aug 01, 2011 | Sale | $17.37 | 1,539 | 26,732 | 1,488 | Aug 03, 2011, 07:27 PM |
| DOBMEIER ERIC | Chief Operating Officer | Aug 01, 2011 | Option Exercise | $5.25 | 25,000 | 131,250 | 33,817 | Aug 03, 2011, 07:21 PM |
| SIMPSON TODD E | Chief Financial Officer | Jul 18, 2011 | Option Exercise | $4.63 | 18,663 | 86,500 | 28,022 | Jul 20, 2011, 07:21 PM |
| SIEGALL CLAY B | President and CEO | Jul 01, 2011 | Option Exercise | $6.34 | 15,000 | 95,100 | 965,667 | Jul 01, 2011, 07:07 PM |
| SIEGALL CLAY B | President and CEO | Jul 01, 2011 | Sale | $20.66 | 15,000 | 309,865 | 950,667 | Jul 01, 2011, 07:07 PM |
| BERGER FRANKLIN M | Director | Jun 22, 2011 | Buy | $20.04 | 7,000 | 140,274 | 163,720 | Jun 23, 2011, 03:38 PM |
| SIEGALL CLAY B | President and CEO | Jun 20, 2011 | Option Exercise | $6.34 | 9,000 | 57,060 | 959,667 | Jun 21, 2011, 06:37 PM |
| SIEGALL CLAY B | President and CEO | Jun 20, 2011 | Sale | $20.01 | 9,000 | 180,071 | 950,667 | Jun 21, 2011, 06:37 PM |
| DOBMEIER ERIC | Chief Operating Officer | Jun 20, 2011 | Sale | $20.00 | 13,385 | 267,700 | 8,817 | Jun 21, 2011, 06:35 PM |
| SIEGALL CLAY B | President and CEO | Jun 09, 2011 | Option Exercise | $6.34 | 1,000 | 6,340 | 951,667 | Jun 13, 2011, 07:42 PM |
| SIEGALL CLAY B | President and CEO | Jun 09, 2011 | Sale | $20.00 | 1,000 | 20,000 | 950,667 | Jun 13, 2011, 07:42 PM |
| DOBMEIER ERIC | Chief Business Officer | Jun 09, 2011 | Sale | $20.00 | 3,600 | 72,000 | 22,202 | Jun 13, 2011, 07:40 PM |
| SIMPSON TODD E | Chief Financial Officer | Jun 07, 2011 | Option Exercise | $5.20 | 10,750 | 55,900 | 20,109 | Jun 09, 2011, 08:31 PM |
| SIMPSON TODD E | Chief Financial Officer | Jun 07, 2011 | Sale | $19.96 | 10,750 | 214,570 | 9,359 | Jun 09, 2011, 08:31 PM |
| ROSENBERG MORRIS | EVP, Process Sciences | Jun 07, 2011 | Option Exercise | $6.34 | 2,503 | 15,869 | 2,503 | Jun 09, 2011, 08:12 PM |
| ROSENBERG MORRIS | EVP, Process Sciences | Jun 07, 2011 | Sale | $19.67 | 2,503 | 49,243 | 0 | Jun 09, 2011, 08:12 PM |
| ROSENBERG MORRIS | EVP, Process Sciences | May 27, 2011 | Option Exercise | $6.34 | 17,497 | 110,931 | 17,497 | Jun 01, 2011, 07:07 PM |
| ROSENBERG MORRIS | EVP, Process Sciences | May 27, 2011 | Sale | $19.50 | 17,497 | 341,192 | 0 | Jun 01, 2011, 07:07 PM |
| Reynolds Thomas C | Chief Medical Officer | May 18, 2011 | Option Exercise | $11.09 | 5,413 | 60,030 | 8,440 | May 20, 2011, 06:39 PM |
| Reynolds Thomas C | Chief Medical Officer | May 19, 2011 | Option Exercise | $11.09 | 14,585 | 161,748 | 9,693 | May 20, 2011, 06:39 PM |
| Reynolds Thomas C | Chief Medical Officer | May 18, 2011 | Sale | $18.70 | 5,413 | 101,223 | 3,027 | May 20, 2011, 06:39 PM |
| Reynolds Thomas C | Chief Medical Officer | May 19, 2011 | Sale | $18.71 | 14,585 | 272,885 | 3,027 | May 20, 2011, 06:39 PM |
| SIEGALL CLAY B | President and CEO | May 18, 2011 | Option Exercise | $6.34 | 5,000 | 31,700 | 950,667 | May 20, 2011, 06:36 PM |
| ROSENBERG MORRIS | EVP, Process Sciences | May 19, 2011 | Option Exercise | $6.34 | 20,000 | 126,800 | 20,000 | May 20, 2011, 06:33 PM |
| ROSENBERG MORRIS | EVP, Process Sciences | May 19, 2011 | Sale | $18.80 | 20,000 | 376,000 | 0 | May 20, 2011, 06:33 PM |
| SIMPSON TODD E | Chief Financial Officer | May 18, 2011 | Option Exercise | $4.95 | 21,250 | 105,110 | 23,422 | May 20, 2011, 06:31 PM |
| SIMPSON TODD E | Chief Financial Officer | May 18, 2011 | Sale | $18.64 | 21,250 | 396,100 | 9,359 | May 20, 2011, 06:31 PM |
| ROSENBERG MORRIS | EVP, Process Sciences | May 13, 2011 | Option Exercise | $6.34 | 20,000 | 126,800 | 20,000 | May 13, 2011, 07:27 PM |
| ROSENBERG MORRIS | EVP, Process Sciences | May 13, 2011 | Sale | $17.80 | 20,000 | 356,000 | 0 | May 13, 2011, 07:27 PM |
| Reynolds Thomas C | Chief Medical Officer | May 13, 2011 | Option Exercise | $8.24 | 20,000 | 164,800 | 8,027 | May 13, 2011, 07:25 PM |
| Reynolds Thomas C | Chief Medical Officer | May 13, 2011 | Sale | $17.80 | 20,000 | 356,000 | 3,027 | May 13, 2011, 07:25 PM |
| DOBMEIER ERIC | Chief Business Officer | May 13, 2011 | Option Exercise | $5.89 | 42,715 | 251,382 | 54,967 | May 13, 2011, 07:22 PM |
| DOBMEIER ERIC | Chief Business Officer | May 13, 2011 | Sale | $18.00 | 42,715 | 768,870 | 25,802 | May 13, 2011, 07:22 PM |
| SIMPSON TODD E | Chief Financial Officer | May 09, 2011 | Option Exercise | $4.45 | 20,000 | 89,000 | 29,359 | May 11, 2011, 05:00 PM |
| SIMPSON TODD E | Chief Financial Officer | May 09, 2011 | Sale | $17.74 | 20,000 | 354,800 | 9,359 | May 11, 2011, 05:00 PM |
| SIEGALL CLAY B | President and CEO | May 09, 2011 | Option Exercise | $8.43 | 50,000 | 421,500 | 995,667 | May 11, 2011, 04:58 PM |
| SIEGALL CLAY B | President and CEO | May 09, 2011 | Sale | $17.35 | 50,000 | 867,705 | 945,667 | May 11, 2011, 04:58 PM |
| SIMPSON TODD E | Chief Financial Officer | Apr 29, 2011 | Option Exercise | $4.45 | 15,000 | 66,750 | 24,359 | May 03, 2011, 06:49 PM |
| SIMPSON TODD E | Chief Financial Officer | Apr 29, 2011 | Sale | $16.94 | 15,000 | 254,100 | 9,359 | May 03, 2011, 06:49 PM |
| Reynolds Thomas C | Chief Medical Officer | Apr 29, 2011 | Option Exercise | $8.24 | 9,999 | 82,392 | 6,360 | May 03, 2011, 06:47 PM |
| Reynolds Thomas C | Chief Medical Officer | Apr 29, 2011 | Sale | $16.95 | 11,915 | 201,959 | 4,114 | May 03, 2011, 06:47 PM |
| SIEGALL CLAY B | President and CEO | May 02, 2011 | Option Exercise | $8.43 | 50,000 | 421,500 | 995,667 | May 03, 2011, 06:44 PM |
| SIEGALL CLAY B | President and CEO | May 02, 2011 | Sale | $17.43 | 50,000 | 871,355 | 945,667 | May 03, 2011, 06:44 PM |
| ROSENBERG MORRIS | EVP, Process Sciences | May 02, 2011 | Option Exercise | $6.72 | 12,500 | 84,000 | 12,500 | May 03, 2011, 06:42 PM |
| ROSENBERG MORRIS | EVP, Process Sciences | Apr 29, 2011 | Option Exercise | $6.72 | 12,500 | 84,000 | 12,500 | May 03, 2011, 06:42 PM |
| ROSENBERG MORRIS | EVP, Process Sciences | May 02, 2011 | Sale | $17.50 | 12,500 | 218,751 | 0 | May 03, 2011, 06:42 PM |
| ROSENBERG MORRIS | EVP, Process Sciences | Apr 29, 2011 | Sale | $16.80 | 12,500 | 210,000 | 0 | May 03, 2011, 06:42 PM |
| SIEGALL CLAY B | President and CEO | Apr 14, 2011 | Option Exercise | $8.43 | 50,000 | 421,500 | 995,667 |