Regeneron Pharmaceuticals, Inc.. (REGN) NASDAQ
$802.16 50.86 (6.77%)
Market Cap: $80.77B
As of 03/23/23 04:00 PM EDT. Market closed.
Regeneron Pharmaceuticals, Inc.. (REGN)
NASDAQ
$802.16
50.86 (6.77%)
Market Cap: $80.77B
As of 03/23/23 04:00 PM EDT. Market closed.
Regeneron is a leading biotechnology company that invents life-transforming medicines for people with serious diseases. Founded and led for over 30 years by physician-scientists, its unique ability to repeatedly and consistently translate science into medicine has led to nine FDA-approved treatments and numerous product candidates in development, almost all of which were homegrown in its ... read more
Regeneron is a leading biotechnology company that invents life-transforming medicines for people with serious diseases. Founded and led for over 30 years by physician-scientists, its unique ability to repeatedly and consistently translate science into medicine has led to nine FDA-approved treatments and numerous product candidates in development, almost all of which were homegrown in its laboratories. Its medicines and pipeline are designed to help patients with eye diseases, allergic and inflammatory diseases, cancer, cardiovascular and metabolic diseases, pain, infectious diseases and rare diseases. read less
COMPANY PROFILE
Sector
Manufacturing
Industry
Pharmaceutical Preparation Manufacturing
CEO
Leonard Schleifer
Full Time Employees
11,851
CEO Compensation (Base)
$1.33M
CEO Compensation (Total)
$26.52M
Sector
Manufacturing
Industry
Pharmaceutical Preparation Manufacturing
CEO
Leonard Schleifer
Full Time Employees
11,851
CEO Compensation (Base)
$1.33M
CEO Compensation (Total)
$26.52M
Address
777 Old Saw Mill River Rd, New York, Tarrytown, 10591-6717.
PRICE CHART FOR REGENERON PHARMACEUTICALS, INC.
From:
To:
NEWS
KEY STATS
Open
$809
Previous Close
$751.30
Days Range
$790.49 - $812.69
52 week range
$538.01 - $800.48
Volume
1,993,986
Avg. Volume (30 days)
573,059
Market Cap
$80.77B
Dividend Yield
0.00%
P/E
18.62
Shares Outstanding
107,507,386
Open
$809
Previous Close
$751.30
Days Range
$790.49 - $812.69
52 week range
$538.01 - $800.48
Volume
1,993,986
Avg. Volume (30 days)
573,059
Market Cap
$80.77B
Dividend Yield
0.00%
P/E
18.62
Shares Outstanding
107,507,386
Open in: 
Open in:
INSIDER TRANSACTIONS FOR REGENERON PHARMACEUTICALS, INC.
| Owner | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| RYAN ARTHUR F | Director | Mar 01, 2023 | Sale | $762.50 | 100 | 76,250 | 19,242 | Mar 03, 2023, 04:03 PM |
| McCourt Marion | EVP Commercial | Mar 01, 2023 | Option Exercise | $372.46 | 1,100 | 409,706 | 21,903 | Mar 03, 2023, 04:03 PM |
| McCourt Marion | EVP Commercial | Mar 01, 2023 | Sale | $759.89 | 1,100 | 835,879 | 20,803 | Mar 03, 2023, 04:03 PM |
| VAGELOS P ROY | Director | Feb 22, 2023 | Option Exercise | $750.16 | 29,005 | 21,758,390 | 337,578 | Feb 24, 2023, 04:07 PM |
| VAGELOS P ROY | Director | Feb 22, 2023 | Option Exercise | $270.43 | 42,500 | 11,493,275 | 366,583 | Feb 24, 2023, 04:07 PM |
| McCourt Marion | EVP Commercial | Feb 12, 2023 | Option Exercise | $751.78 | 1,276 | 959,271 | 20,803 | Feb 14, 2023, 04:24 PM |
| GOLDSTEIN JOSEPH L | Director | Feb 06, 2023 | Option Exercise | $482.68 | 3,613 | 1,743,923 | 9,860 | Feb 08, 2023, 04:16 PM |
| GOLDSTEIN JOSEPH L | Director | Feb 06, 2023 | Sale | $800.00 | 3,613 | 2,890,400 | 6,247 | Feb 08, 2023, 04:16 PM |
| BROWN MICHAEL S | Director | Feb 06, 2023 | Option Exercise | $520.01 | 3,071 | 1,596,951 | 4,318 | Feb 08, 2023, 04:15 PM |
| BROWN MICHAEL S | Director | Feb 06, 2023 | Sale | $797.00 | 500 | 398,500 | 6,162 | Feb 08, 2023, 04:15 PM |
| BROWN MICHAEL S | Director | Feb 06, 2023 | Sale | $798.00 | 3,071 | 2,450,658 | 1,247 | Feb 08, 2023, 04:15 PM |
| YANCOPOULOS GEORGE | President and Chief Scientific | Feb 06, 2023 | Sale | $800.08 | 13,189 | 10,552,255 | 200,504 | Feb 08, 2023, 04:15 PM |
| McCourt Marion | EVP Commercial | Feb 07, 2023 | Option Exercise | $372.46 | 1,000 | 372,460 | 23,079 | Feb 08, 2023, 04:14 PM |
| McCourt Marion | EVP Commercial | Feb 07, 2023 | Sale | $769.04 | 1,000 | 769,040 | 22,079 | Feb 08, 2023, 04:14 PM |
| Fenimore Christopher R. | SVP Controller | Feb 03, 2023 | Option Exercise | $774.29 | 3,286 | 2,544,317 | 20,295 | Feb 07, 2023, 04:10 PM |
| Fenimore Christopher R. | SVP Controller | Feb 03, 2023 | Option Exercise | $270.43 | 5,000 | 1,352,150 | 23,581 | Feb 07, 2023, 04:10 PM |
| Bassler Bonnie L | Director | Feb 03, 2023 | Option Exercise | $380.95 | 1,021 | 388,950 | 2,268 | Feb 07, 2023, 04:09 PM |
| Bassler Bonnie L | Director | Feb 03, 2023 | Sale | $779.00 | 1,021 | 795,359 | 1,247 | Feb 07, 2023, 04:09 PM |
| Landry Robert E | EVP Finance CFO | Feb 03, 2023 | Option Exercise | $774.29 | 2,248 | 1,740,604 | 32,857 | Feb 07, 2023, 04:09 PM |
| Landry Robert E | EVP Finance CFO | Feb 03, 2023 | Option Exercise | $381.92 | 3,000 | 1,145,760 | 35,105 | Feb 07, 2023, 04:09 PM |
| Landry Robert E | EVP Finance CFO | Feb 03, 2023 | Sale | $764.50 | 739 | 564,966 | 32,105 | Feb 07, 2023, 04:09 PM |
| Landry Robert E | EVP Finance CFO | Feb 06, 2023 | Sale | $788.88 | 752 | 593,238 | 32,806 | Feb 07, 2023, 04:09 PM |
| RYAN ARTHUR F | Director | Feb 01, 2023 | Sale | $756.13 | 100 | 75,613 | 19,345 | Feb 03, 2023, 04:15 PM |
| McCourt Marion | EVP Commercial | Feb 01, 2023 | Option Exercise | $372.46 | 1,100 | 409,706 | 23,179 | Feb 03, 2023, 04:13 PM |
| McCourt Marion | EVP Commercial | Feb 01, 2023 | Sale | $752.19 | 1,100 | 827,409 | 22,079 | Feb 03, 2023, 04:13 PM |
| BROWN MICHAEL S | Director | Jan 27, 2023 | Option Exercise | $520.01 | 1 | 520 | 1,248 | Jan 30, 2023, 04:11 PM |
| BROWN MICHAEL S | Director | Jan 27, 2023 | Sale | $747.00 | 1 | 747 | 1,247 | Jan 30, 2023, 04:11 PM |
| BROWN MICHAEL S | Director | Jan 06, 2023 | Option Exercise | $520.01 | 3,070 | 1,596,431 | 4,317 | Jan 10, 2023, 04:03 PM |
| BROWN MICHAEL S | Director | Jan 06, 2023 | Sale | $747.14 | 3,070 | 2,293,720 | 1,247 | Jan 10, 2023, 04:03 PM |
| RYAN ARTHUR F | Director | Jan 03, 2023 | Sale | $726.29 | 100 | 72,629 | 19,268 | Jan 05, 2023, 04:37 PM |
| McCourt Marion | EVP Commercial | Jan 03, 2023 | Option Exercise | $372.46 | 1,100 | 409,706 | 23,179 | Jan 05, 2023, 04:22 PM |
| McCourt Marion | EVP Commercial | Jan 03, 2023 | Sale | $721.86 | 1,100 | 794,046 | 22,079 | Jan 05, 2023, 04:22 PM |
| COLES N ANTHONY | Director | Dec 28, 2022 | Option Exercise | $442.24 | 5,758 | 2,546,410 | 6,851 | Dec 30, 2022, 04:10 PM |
| COLES N ANTHONY | Director | Dec 28, 2022 | Sale | $714.11 | 5,758 | 4,111,822 | 6,670 | Dec 30, 2022, 04:10 PM |
| VAGELOS P ROY | Director | Dec 20, 2022 | Option Exercise | $729.53 | 141 | 102,864 | 2,072 | Dec 21, 2022, 05:45 PM |
| McCourt Marion | EVP Commercial | Dec 09, 2022 | Option Exercise | $753.28 | 274 | 206,399 | 19,370 | Dec 13, 2022, 04:13 PM |
| McCourt Marion | EVP Commercial | Dec 12, 2022 | Sale | $730.17 | 264 | 192,765 | 19,106 | Dec 13, 2022, 04:13 PM |
| LAROSA JOSEPH J | EVP General Counsel and Secret | Dec 09, 2022 | Option Exercise | $753.28 | 492 | 370,614 | 20,358 | Dec 13, 2022, 04:12 PM |
| VAGELOS P ROY | Director | Dec 09, 2022 | Option Exercise | $753.28 | 57 | 42,937 | 322,432 | Dec 13, 2022, 04:12 PM |
| MURPHY ANDREW J | EVP Research | Dec 09, 2022 | Option Exercise | $753.28 | 492 | 370,614 | 56,618 | Dec 13, 2022, 04:12 PM |
| STAHL NEIL | EVP Research and Development | Dec 09, 2022 | Option Exercise | $753.28 | 466 | 351,028 | 51,999 | Dec 13, 2022, 04:11 PM |
| Van Plew Daniel P | EVP & General Mgr, Industrial | Dec 09, 2022 | Option Exercise | $753.28 | 492 | 370,614 | 30,086 | Dec 13, 2022, 04:10 PM |
| Fenimore Christopher R. | SVP Controller | Dec 09, 2022 | Option Exercise | $753.28 | 247 | 186,060 | 16,655 | Dec 13, 2022, 04:09 PM |
| Bassler Bonnie L | Director | Dec 08, 2022 | Option Exercise | $380.95 | 218 | 83,047 | 1,300 | Dec 12, 2022, 04:35 PM |
| Bassler Bonnie L | Director | Dec 08, 2022 | Sale | $779.00 | 218 | 169,822 | 1,082 | Dec 12, 2022, 04:35 PM |
| Landry Robert E | EVP Finance CFO | Dec 09, 2022 | Option Exercise | $753.28 | 492 | 370,614 | 28,991 | Dec 12, 2022, 04:34 PM |
| Landry Robert E | EVP Finance CFO | Dec 08, 2022 | Option Exercise | $768.54 | 2,261 | 1,737,669 | 29,483 | Dec 12, 2022, 04:34 PM |
| Landry Robert E | EVP Finance CFO | Dec 08, 2022 | Option Exercise | $381.92 | 3,000 | 1,145,760 | 31,744 | Dec 12, 2022, 04:34 PM |
| RYAN ARTHUR F | Director | Dec 01, 2022 | Sale | $758.17 | 100 | 75,817 | 19,379 | Dec 02, 2022, 04:07 PM |
| McCourt Marion | EVP Commercial | Dec 01, 2022 | Option Exercise | $372.46 | 1,100 | 409,706 | 20,744 | Dec 02, 2022, 04:06 PM |
| McCourt Marion | EVP Commercial | Dec 01, 2022 | Sale | $756.19 | 1,100 | 831,809 | 19,644 | Dec 02, 2022, 04:06 PM |
| Landry Robert E | EVP Finance CFO | Dec 01, 2022 | Option Exercise | $760.35 | 1,890 | 1,437,061 | 29,354 | Dec 02, 2022, 04:05 PM |
| Landry Robert E | EVP Finance CFO | Dec 01, 2022 | Option Exercise | $381.92 | 2,500 | 954,800 | 31,244 | Dec 02, 2022, 04:05 PM |
| Landry Robert E | EVP Finance CFO | Dec 02, 2022 | Sale | $756.66 | 610 | 461,564 | 28,772 | Dec 02, 2022, 04:05 PM |
| Van Plew Daniel P | EVP & General Mgr, Industrial | Nov 22, 2022 | Option Exercise | $741.81 | 38,028 | 28,209,551 | 42,550 | Nov 25, 2022, 01:07 PM |
| Van Plew Daniel P | EVP & General Mgr, Industrial | Nov 22, 2022 | Option Exercise | $378.98 | 50,000 | 18,949,001 | 80,578 | Nov 25, 2022, 01:07 PM |
| Van Plew Daniel P | EVP & General Mgr, Industrial | Nov 23, 2022 | Sale | $740.75 | 11,972 | 8,868,260 | 41,864 | Nov 25, 2022, 01:07 PM |
| MURPHY ANDREW J | EVP Research | Nov 14, 2022 | Option Exercise | $746.00 | 6,280 | 4,684,880 | 60,830 | Nov 16, 2022, 04:01 PM |
| MURPHY ANDREW J | EVP Research | Nov 14, 2022 | Option Exercise | $179.13 | 10,000 | 1,791,300 | 67,110 | Nov 16, 2022, 04:01 PM |
| MURPHY ANDREW J | EVP Research | Nov 15, 2022 | Sale | $727.81 | 3,720 | 2,707,467 | 60,721 | Nov 16, 2022, 04:01 PM |
| BROWN MICHAEL S | Director | Nov 08, 2022 | Option Exercise | $416.62 | 3,995 | 1,664,397 | 3,513 | Nov 10, 2022, 04:00 PM |
| BROWN MICHAEL S | Director | Nov 08, 2022 | Sale | $748.49 | 500 | 374,245 | 6,662 | Nov 10, 2022, 04:00 PM |
| BROWN MICHAEL S | Director | Nov 08, 2022 | Sale | $755.18 | 3,995 | 3,016,946 | 3,187 | Nov 10, 2022, 04:00 PM |
| Van Plew Daniel P | EVP & General Mgr, Industrial | Nov 04, 2022 | Option Exercise | $725.84 | 26,114 | 18,954,586 | 38,464 | Nov 08, 2022, 04:00 PM |
| Van Plew Daniel P | EVP & General Mgr, Industrial | Nov 04, 2022 | Option Exercise | $381.92 | 34,000 | 12,985,280 | 64,578 | Nov 08, 2022, 04:00 PM |
| Van Plew Daniel P | EVP & General Mgr, Industrial | Nov 07, 2022 | Sale | $745.40 | 7,886 | 5,878,263 | 38,364 | Nov 08, 2022, 04:00 PM |
| McCourt Marion | EVP Commercial | Nov 04, 2022 | Option Exercise | $372.46 | 1,000 | 372,460 | 20,644 | Nov 07, 2022, 04:05 PM |
| McCourt Marion | EVP Commercial | Nov 04, 2022 | Sale | $727.82 | 1,000 | 727,820 | 19,644 | Nov 07, 2022, 04:05 PM |
| RYAN ARTHUR F | Director | Nov 01, 2022 | Sale | $755.89 | 100 | 75,589 | 19,480 | Nov 03, 2022, 04:03 PM |
| Landry Robert E | EVP Finance CFO | Oct 31, 2022 | Option Exercise | $751.24 | 1,518 | 1,140,382 | 29,226 | Nov 02, 2022, 04:04 PM |
| Landry Robert E | EVP Finance CFO | Oct 31, 2022 | Option Exercise | $381.92 | 2,000 | 763,840 | 30,744 | Nov 02, 2022, 04:04 PM |
| Landry Robert E | EVP Finance CFO | Nov 01, 2022 | Sale | $758.06 | 482 | 365,386 | 29,225 | Nov 02, 2022, 04:04 PM |
| McCourt Marion | EVP Commercial | Nov 01, 2022 | Option Exercise | $372.46 | 1,100 | 409,706 | 20,744 | Nov 02, 2022, 04:03 PM |
| McCourt Marion | EVP Commercial | Nov 01, 2022 | Sale | $750.00 | 1,100 | 825,000 | 19,644 | Nov 02, 2022, 04:03 PM |
| Landry Robert E | EVP Finance CFO | Oct 14, 2022 | Option Exercise | $743.78 | 1,142 | 849,397 | 29,102 | Oct 18, 2022, 04:06 PM |
| Landry Robert E | EVP Finance CFO | Oct 14, 2022 | Option Exercise | $381.92 | 1,500 | 572,880 | 30,244 | Oct 18, 2022, 04:06 PM |
| Landry Robert E | EVP Finance CFO | Oct 17, 2022 | Sale | $739.50 | 358 | 264,741 | 28,744 | Oct 18, 2022, 04:06 PM |
| Fenimore Christopher R. | SVP Controller | Oct 05, 2022 | Sale | $749.00 | 1,844 | 1,381,156 | 16,425 | Oct 07, 2022, 04:03 PM |
| McCourt Marion | EVP Commercial | Oct 03, 2022 | Option Exercise | $359.04 | 1,100 | 394,941 | 20,244 | Oct 05, 2022, 04:11 PM |
| McCourt Marion | EVP Commercial | Oct 03, 2022 | Sale | $705.39 | 1,100 | 775,929 | 19,644 | Oct 05, 2022, 04:11 PM |
| Fenimore Christopher R. | SVP Controller | Oct 03, 2022 | Sale | $724.00 | 3,346 | 2,422,504 | 18,269 | Oct 05, 2022, 04:10 PM |
| RYAN ARTHUR F | Director | Oct 03, 2022 | Sale | $726.54 | 100 | 72,654 | 19,580 | Oct 05, 2022, 04:10 PM |
| Tessier-Lavigne Marc | Director | Sep 30, 2022 | Option Exercise | $413.33 | 3,428 | 1,416,895 | 5,697 | Oct 03, 2022, 04:05 PM |
| Tessier-Lavigne Marc | Director | Sep 29, 2022 | Option Exercise | $413.33 | 3,798 | 1,569,827 | 6,067 | Oct 03, 2022, 04:05 PM |
| Tessier-Lavigne Marc | Director | Oct 03, 2022 | Option Exercise | $413.33 | 3,612 | 1,492,948 | 5,881 | Oct 03, 2022, 04:05 PM |
| Tessier-Lavigne Marc | Director | Sep 30, 2022 | Sale | $698.00 | 3,428 | 2,392,744 | 2,269 | Oct 03, 2022, 04:05 PM |
| Tessier-Lavigne Marc | Director | Sep 29, 2022 | Sale | $691.07 | 3,798 | 2,624,684 | 6,051 | Oct 03, 2022, 04:05 PM |
| Tessier-Lavigne Marc | Director | Oct 03, 2022 | Sale | $718.00 | 3,612 | 2,593,416 | 2,269 | Oct 03, 2022, 04:05 PM |
| Van Plew Daniel P | EVP & General Mgr, Industrial | Sep 09, 2022 | Option Exercise | $730.96 | 35,304 | 25,805,813 | 35,274 | Sep 13, 2022, 04:04 PM |
| Van Plew Daniel P | EVP & General Mgr, Industrial | Sep 09, 2022 | Option Exercise | $555.67 | 40,000 | 22,226,799 | 70,578 | Sep 13, 2022, 04:04 PM |
| Van Plew Daniel P | EVP & General Mgr, Industrial | Sep 12, 2022 | Sale | $716.38 | 4,696 | 3,364,111 | 35,187 | Sep 13, 2022, 04:04 PM |
| Bassler Bonnie L | Director | Sep 09, 2022 | Option Exercise | $376.69 | 609 | 229,404 | 1,691 | Sep 12, 2022, 04:31 PM |
| Bassler Bonnie L | Director | Sep 08, 2022 | Option Exercise | $391.92 | 2,558 | 1,002,531 | 2,361 | Sep 12, 2022, 04:31 PM |
| Bassler Bonnie L | Director | Sep 09, 2022 | Sale | $741.00 | 609 | 451,269 | 1,082 | Sep 12, 2022, 04:31 PM |
| Bassler Bonnie L | Director | Sep 08, 2022 | Sale | $695.99 | 2,558 | 1,780,355 | 1,082 | Sep 12, 2022, 04:31 PM |
| LAROSA JOSEPH J | EVP General Counsel and Secret | Sep 09, 2022 | Option Exercise | $730.96 | 20,730 | 15,152,801 | 20,850 | Sep 12, 2022, 04:30 PM |
| LAROSA JOSEPH J | EVP General Counsel and Secret | Sep 09, 2022 | Option Exercise | $270.43 | 30,000 | 8,112,900 | 41,580 | Sep 12, 2022, 04:30 PM |
| RYAN ARTHUR F | Director | Sep 06, 2022 | Sale | $582.37 | 100 | 58,237 | 19,679 | Sep 08, 2022, 04:07 PM |
| COLES N ANTHONY | Director | Sep 06, 2022 | Option Exercise | $372.40 | 6,000 | 2,234,427 | 6,793 | Sep 08, 2022, 04:06 PM |
| COLES N ANTHONY | Director | Sep 06, 2022 | Sale | $581.28 | 6,000 | 3,487,657 | 6,293 | Sep 08, 2022, 04:06 PM |
| McCourt Marion | EVP Commercial | Sep 01, 2022 | Option Exercise | $342.93 | 1,100 | 377,223 | 20,744 | Sep 02, 2022, 04:07 PM |
| McCourt Marion | EVP Commercial | Sep 01, 2022 | Sale | $577.62 | 1,100 | 635,382 | 19,644 | Sep 02, 2022, 04:07 PM |
| MURPHY ANDREW J | EVP Research | Aug 15, 2022 | Option Exercise | $634.25 | 6,487 | 4,114,380 | 61,983 | Aug 17, 2022, 04:04 PM |
| MURPHY ANDREW J | EVP Research | Aug 15, 2022 | Option Exercise | $179.13 | 10,000 | 1,791,300 | 68,470 | Aug 17, 2022, 04:04 PM |
| MURPHY ANDREW J | EVP Research | Aug 16, 2022 | Sale | $645.49 | 3,513 | 2,267,600 | 61,907 | Aug 17, 2022, 04:04 PM |
| POON CHRISTINE A | Director | Aug 09, 2022 | Option Exercise | $177.82 | 15,000 | 2,667,300 | 16,872 | Aug 11, 2022, 04:09 PM |
| POON CHRISTINE A | Director | Aug 09, 2022 | Sale | $620.91 | 15,000 | 9,313,599 | 10,058 | Aug 11, 2022, 04:09 PM |
| RYAN ARTHUR F | Director | Aug 04, 2022 | Option Exercise | $413.26 | 10,453 | 4,319,835 | 23,295 | Aug 08, 2022, 04:12 PM |
| RYAN ARTHUR F | Director | Aug 04, 2022 | Sale | $621.29 | 10,453 | 6,494,319 | 19,682 | Aug 08, 2022, 04:12 PM |
| STAHL NEIL | EVP Research and Development | Aug 04, 2022 | Option Exercise | $613.00 | 71,218 | 43,656,634 | 76,577 | Aug 08, 2022, 04:11 PM |
| STAHL NEIL | EVP Research and Development | Aug 04, 2022 | Option Exercise | $270.43 | 95,000 | 25,690,849 | 147,795 | Aug 08, 2022, 04:11 PM |
| STAHL NEIL | EVP Research and Development | Aug 05, 2022 | Sale | $612.61 | 23,782 | 14,569,134 | 76,401 | Aug 08, 2022, 04:11 PM |
| McCourt Marion | EVP Commercial | Aug 01, 2022 | Option Exercise | $342.93 | 1,100 | 377,223 | 20,744 | Aug 02, 2022, 04:28 PM |
| McCourt Marion | EVP Commercial | Aug 01, 2022 | Sale | $581.53 | 1,100 | 639,683 | 19,644 | Aug 02, 2022, 04:28 PM |
| McCourt Marion | EVP Commercial | Jul 01, 2022 | Option Exercise | $342.93 | 1,100 | 377,223 | 20,744 | Jul 05, 2022, 04:03 PM |
| McCourt Marion | EVP Commercial | Jul 01, 2022 | Sale | $587.76 | 1,100 | 646,536 | 19,644 | Jul 05, 2022, 04:03 PM |
| McCourt Marion | EVP Commercial | Jun 01, 2022 | Option Exercise | $342.93 | 1,100 | 377,223 | 20,744 | Jun 03, 2022, 04:00 PM |
| McCourt Marion | EVP Commercial | Jun 01, 2022 | Sale | $669.51 | 1,100 | 736,461 | 19,644 | Jun 03, 2022, 04:00 PM |
| MURPHY ANDREW J | EVP Research | May 16, 2022 | Option Exercise | $648.31 | 6,457 | 4,186,138 | 62,013 | May 18, 2022, 04:05 PM |
| MURPHY ANDREW J | EVP Research | May 16, 2022 | Option Exercise | $179.13 | 10,000 | 1,791,300 | 68,470 | May 18, 2022, 04:05 PM |
| MURPHY ANDREW J | EVP Research | May 17, 2022 | Sale | $663.68 | 3,543 | 2,351,411 | 61,954 | May 18, 2022, 04:05 PM |
| RYAN ARTHUR F | Director | May 02, 2022 | Sale | $650.78 | 100 | 65,078 | 22,277 | May 03, 2022, 05:10 PM |
| McCourt Marion | EVP Commercial | May 02, 2022 | Option Exercise | $342.93 | 1,100 | 377,223 | 20,744 | May 03, 2022, 05:09 PM |
| McCourt Marion | EVP Commercial | May 02, 2022 | Sale | $656.97 | 1,100 | 722,667 | 19,644 | May 03, 2022, 05:09 PM |
| Landry Robert E | EVP Finance CFO | Apr 08, 2022 | Option Exercise | $736.21 | 6,138 | 4,518,857 | 30,606 | Apr 11, 2022, 06:01 PM |
| Landry Robert E | EVP Finance CFO | Apr 07, 2022 | Option Exercise | $716.09 | 1,175 | 841,406 | 29,069 | Apr 11, 2022, 06:01 PM |
| Landry Robert E | EVP Finance CFO | Apr 07, 2022 | Option Exercise | $399.66 | 1,500 | 599,490 | 30,244 | Apr 11, 2022, 06:01 PM |
| Landry Robert E | EVP Finance CFO | Apr 08, 2022 | Option Exercise | $386.36 | 8,000 | 3,090,840 | 34,744 | Apr 11, 2022, 06:01 PM |
| Landry Robert E | EVP Finance CFO | Apr 11, 2022 | Sale | $734.06 | 1,862 | 1,366,821 | 30,532 | Apr 11, 2022, 06:01 PM |
| Landry Robert E | EVP Finance CFO | Apr 08, 2022 | Sale | $737.79 | 325 | 239,780 | 29,053 | Apr 11, 2022, 06:01 PM |
| LAROSA JOSEPH J | EVP General Counsel and Secret | Apr 07, 2022 | Sale | $721.10 | 5,114 | 3,687,705 | 16,900 | Apr 11, 2022, 04:41 PM |
| Fenimore Christopher R. | SVP Controller | Apr 08, 2022 | Option Exercise | $736.21 | 5,606 | 4,127,193 | 26,615 | Apr 11, 2022, 04:40 PM |
| Fenimore Christopher R. | SVP Controller | Apr 08, 2022 | Option Exercise | $364.23 | 7,450 | 2,713,541 | 30,066 | Apr 11, 2022, 04:40 PM |
| Bassler Bonnie L | Director | Apr 07, 2022 | Option Exercise | $380.95 | 1,240 | 472,378 | 2,322 | Apr 11, 2022, 04:38 PM |
| Bassler Bonnie L | Director | Apr 07, 2022 | Sale | $725.00 | 1,240 | 899,000 | 1,082 | Apr 11, 2022, 04:38 PM |
| SCHLEIFER LEONARD S | President & CEO | Apr 05, 2022 | Sale | $710.05 | 4,461 | 3,167,533 | 13,831 | Apr 07, 2022, 04:04 PM |
| SCHLEIFER LEONARD S | President & CEO | Apr 06, 2022 | Sale | $710.04 | 2,653 | 1,883,736 | 11,178 | Apr 07, 2022, 04:04 PM |
| McCourt Marion | EVP Commercial | Apr 01, 2022 | Option Exercise | $342.93 | 1,000 | 342,930 | 20,644 | Apr 04, 2022, 04:05 PM |
| McCourt Marion | EVP Commercial | Apr 01, 2022 | Sale | $701.82 | 1,000 | 701,820 | 19,644 | Apr 04, 2022, 04:05 PM |
| LAROSA JOSEPH J | EVP General Counsel and Secret | Apr 01, 2022 | Sale | $690.73 | 5,114 | 3,532,373 | 26,759 | Apr 04, 2022, 04:04 PM |
| SCHLEIFER LEONARD S | President & CEO | Mar 31, 2022 | Sale | $710.01 | 2,886 | 2,049,089 | 18,292 | Apr 04, 2022, 04:03 PM |
| RYAN ARTHUR F | Director | Apr 01, 2022 | Sale | $692.81 | 100 | 69,281 | 22,376 | Apr 04, 2022, 04:03 PM |
| GOLDSTEIN JOSEPH L | Director | Mar 30, 2022 | Option Exercise | $374.12 | 2,431 | 909,486 | 8,513 | Apr 01, 2022, 04:08 PM |
| GOLDSTEIN JOSEPH L | Director | Mar 30, 2022 | Sale | $700.00 | 2,431 | 1,701,700 | 6,082 | Apr 01, 2022, 04:08 PM |
| VAGELOS P ROY | Director | Mar 30, 2022 | Sale | $700.00 | 14,286 | 10,000,200 | 23,461 | Apr 01, 2022, 04:08 PM |
| VAGELOS P ROY | Director | Mar 30, 2022 | Sale | $700.02 | 14,286 | 10,000,486 | 127,006 | Apr 01, 2022, 04:08 PM |
| Bassler Bonnie L | Director | Mar 30, 2022 | Option Exercise | $380.95 | 1,240 | 472,378 | 2,322 | Apr 01, 2022, 04:08 PM |
| Bassler Bonnie L | Director | Mar 30, 2022 | Sale | $700.00 | 1,240 | 868,000 | 1,082 | Apr 01, 2022, 04:08 PM |
| Fenimore Christopher R. | SVP Controller | Mar 31, 2022 | Option Exercise | $700.99 | 8,654 | 6,066,367 | 24,771 | Apr 01, 2022, 04:07 PM |
| Fenimore Christopher R. | SVP Controller | Mar 31, 2022 | Option Exercise | $317.97 | 12,000 | 3,815,640 | 31,628 | Apr 01, 2022, 04:07 PM |
| Landry Robert E | EVP Finance CFO | Mar 31, 2022 | Option Exercise | $700.99 | 1,184 | 829,972 | 29,060 | Apr 01, 2022, 04:07 PM |
| Landry Robert E | EVP Finance CFO | Mar 31, 2022 | Option Exercise | $399.66 | 1,500 | 599,490 | 30,244 | Apr 01, 2022, 04:07 PM |
| Landry Robert E | EVP Finance CFO | Apr 01, 2022 | Sale | $695.81 | 316 | 219,875 | 28,759 | Apr 01, 2022, 04:07 PM |
| BROWN MICHAEL S | Director | Mar 29, 2022 | Option Exercise | $374.12 | 1,522 | 569,411 | 2,604 | Mar 31, 2022, 04:04 PM |
| BROWN MICHAEL S | Director | Mar 30, 2022 | Option Exercise | $374.12 | 408 | 152,641 | 1,490 | Mar 31, 2022, 04:04 PM |
| BROWN MICHAEL S | Director | Mar 30, 2022 | Sale | $699.00 | 408 | 285,192 | 1,082 | Mar 31, 2022, 04:04 PM |
| BROWN MICHAEL S | Director | Mar 29, 2022 | Sale | $699.00 | 1,522 | 1,063,878 | 1,082 | Mar 31, 2022, 04:04 PM |
| Landry Robert E | EVP Finance CFO | Mar 28, 2022 | Option Exercise | $685.26 | 11,817 | 8,097,718 | 31,427 | Mar 30, 2022, 04:42 PM |
| Landry Robert E | EVP Finance CFO | Mar 28, 2022 | Option Exercise | $426.56 | 14,500 | 6,185,095 | 34,293 | Mar 30, 2022, 04:42 PM |
| Landry Robert E | EVP Finance CFO | Mar 29, 2022 | Sale | $687.90 | 2,683 | 1,845,630 | 31,373 | Mar 30, 2022, 04:42 PM |
| Landry Robert E | EVP Finance CFO | Mar 21, 2022 | Option Exercise | $691.31 | 312 | 215,689 | 28,744 | Mar 23, 2022, 04:02 PM |
| Landry Robert E | EVP Finance CFO | Mar 21, 2022 | Option Exercise | $381.92 | 400 | 152,768 | 29,056 | Mar 23, 2022, 04:02 PM |
| Landry Robert E | EVP Finance CFO | Mar 21, 2022 | Sale | $693.00 | 300 | 207,900 | 28,656 | Mar 23, 2022, 04:02 PM |
| Tessier-Lavigne Marc | Director | Mar 21, 2022 | Option Exercise | $380.95 | 7,439 | 2,833,887 | 9,708 | Mar 23, 2022, 04:01 PM |
| Tessier-Lavigne Marc | Director | Mar 21, 2022 | Sale | $690.00 | 7,439 | 5,132,910 | 2,269 | Mar 23, 2022, 04:01 PM |
| Zoghbi Huda Y | Director | Mar 16, 2022 | Option Exercise | $391.92 | 2,000 | 783,840 | 3,082 | Mar 18, 2022, 04:14 PM |
| Zoghbi Huda Y | Director | Mar 16, 2022 | Sale | $675.00 | 2,000 | 1,350,000 | 1,082 | Mar 18, 2022, 04:14 PM |
| Landry Robert E | EVP Finance CFO | Mar 17, 2022 | Option Exercise | $682.50 | 286 | 195,195 | 28,956 | Mar 18, 2022, 04:08 PM |
| Landry Robert E | EVP Finance CFO | Mar 17, 2022 | Option Exercise | $381.92 | 365 | 139,401 | 29,242 | Mar 18, 2022, 04:08 PM |
| Landry Robert E | EVP Finance CFO | Mar 17, 2022 | Sale | $686.00 | 83 | 56,938 | 28,877 | Mar 18, 2022, 04:08 PM |
| Landry Robert E | EVP Finance CFO | Mar 16, 2022 | Sale | $677.00 | 300 | 203,100 | 28,960 | Mar 18, 2022, 04:08 PM |
| Tessier-Lavigne Marc | Director | Mar 17, 2022 | Option Exercise | $376.69 | 7,830 | 2,949,483 | 10,099 | Mar 18, 2022, 04:05 PM |
| Tessier-Lavigne Marc | Director | Mar 16, 2022 | Option Exercise | $374.12 | 4,361 | 1,631,537 | 6,630 | Mar 18, 2022, 04:05 PM |
| Tessier-Lavigne Marc | Director | Mar 17, 2022 | Sale | $680.00 | 7,830 | 5,324,400 | 2,269 | Mar 18, 2022, 04:05 PM |
| Tessier-Lavigne Marc | Director | Mar 16, 2022 | Sale | $675.00 | 4,361 | 2,943,675 | 2,269 | Mar 18, 2022, 04:05 PM |
| VAGELOS P ROY | Director | Mar 14, 2022 | Option Exercise | $655.29 | 48,103 | 31,521,414 | 345,566 | Mar 15, 2022, 04:01 PM |
| VAGELOS P ROY | Director | Mar 14, 2022 | Option Exercise | $179.13 | 75,000 | 13,434,750 | 393,669 | Mar 15, 2022, 04:01 PM |
| RYAN ARTHUR F | Director | Mar 01, 2022 | Sale | $618.37 | 100 | 61,837 | 22,479 | Mar 03, 2022, 04:19 PM |
| McCourt Marion | EVP Commercial | Mar 01, 2022 | Option Exercise | $342.93 | 1,000 | 342,930 | 20,644 | Mar 03, 2022, 04:07 PM |
| McCourt Marion | EVP Commercial | Mar 01, 2022 | Sale | $615.39 | 1,000 | 615,390 | 19,644 | Mar 03, 2022, 04:07 PM |
| Van Plew Daniel P | EVP & General Mgr, Industrial | Feb 22, 2022 | Option Exercise | $610.56 | 33,219 | 20,282,193 | 37,359 | Feb 24, 2022, 04:11 PM |
| Van Plew Daniel P | EVP & General Mgr, Industrial | Feb 22, 2022 | Option Exercise | $399.66 | 40,000 | 15,986,400 | 70,578 | Feb 24, 2022, 04:11 PM |
| Van Plew Daniel P | EVP & General Mgr, Industrial | Feb 23, 2022 | Sale | $613.99 | 6,781 | 4,163,489 | 37,203 | Feb 24, 2022, 04:11 PM |
| BROWN MICHAEL S | Director | Feb 23, 2022 | Sale | $608.68 | 500 | 304,340 | 7,162 | Feb 24, 2022, 04:07 PM |
| MURPHY ANDREW J | EVP Research | Feb 14, 2022 | Option Exercise | $626.79 | 6,460 | 4,049,063 | 62,010 | Feb 16, 2022, 04:18 PM |
| MURPHY ANDREW J | EVP Research | Feb 14, 2022 | Option Exercise | $179.13 | 10,000 | 1,791,300 | 68,470 | Feb 16, 2022, 04:18 PM |
| MURPHY ANDREW J | EVP Research | Feb 15, 2022 | Sale | $629.34 | 3,540 | 2,227,850 | 61,911 | Feb 16, 2022, 04:18 PM |
| RYAN ARTHUR F | Director | Feb 01, 2022 | Sale | $607.14 | 100 | 60,714 | 22,580 | Feb 02, 2022, 04:16 PM |
| McCourt Marion | EVP Commercial | Feb 01, 2022 | Option Exercise | $342.93 | 1,000 | 342,930 | 20,644 | Feb 02, 2022, 04:14 PM |
| McCourt Marion | EVP Commercial | Feb 01, 2022 | Sale | $607.46 | 1,000 | 607,460 | 19,644 | Feb 02, 2022, 04:14 PM |
| McCourt Marion | EVP Commercial | Jan 03, 2022 | Option Exercise | $342.93 | 1,000 | 342,930 | 20,644 | Jan 05, 2022, 04:25 PM |
| McCourt Marion | EVP Commercial | Jan 03, 2022 | Sale | $625.00 | 1,000 | 625,000 | 19,644 | Jan 05, 2022, 04:25 PM |
| RYAN ARTHUR F | Director | Jan 03, 2022 | Sale | $624.95 | 100 | 62,495 | 22,490 | Jan 05, 2022, 04:22 PM |
| YANCOPOULOS GEORGE | President and Chief Scientific | Dec 22, 2021 | Option Exercise | $610.04 | 310,097 | 189,171,567 | 1,019,653 | Dec 23, 2021, 04:29 PM |
| YANCOPOULOS GEORGE | President and Chief Scientific | Dec 22, 2021 | Option Exercise | $221.08 | 442,267 | 97,775,813 | 1,169,835 | Dec 23, 2021, 04:29 PM |
| VAGELOS P ROY | Director | Dec 16, 2021 | Option Exercise | $634.98 | 126 | 80,008 | 2,202 | Dec 20, 2021, 04:13 PM |
| Fenimore Christopher R. | SVP Controller | Dec 11, 2021 | Option Exercise | $664.34 | 270 | 179,372 | 21,122 | Dec 14, 2021, 04:10 PM |
| MURPHY ANDREW J | EVP Research | Dec 11, 2021 | Option Exercise | $664.34 | 697 | 463,045 | 58,470 | Dec 14, 2021, 04:09 PM |
| STAHL NEIL | EVP Research and Development | Dec 11, 2021 | Option Exercise | $664.34 | 753 | 500,248 | 53,130 | Dec 14, 2021, 04:08 PM |
| LAROSA JOSEPH J | EVP General Counsel and Secret | Dec 11, 2021 | Option Exercise | $664.34 | 697 | 463,045 | 26,051 | Dec 14, 2021, 04:07 PM |
| McCourt Marion | EVP Commercial | Dec 11, 2021 | Option Exercise | $664.34 | 388 | 257,764 | 19,988 | Dec 14, 2021, 04:05 PM |
| McCourt Marion | EVP Commercial | Dec 13, 2021 | Sale | $653.12 | 344 | 224,673 | 19,644 | Dec 14, 2021, 04:05 PM |
| Van Plew Daniel P | EVP & General Mgr, Industrial | Dec 11, 2021 | Option Exercise | $664.34 | 697 | 463,045 | 30,578 | Dec 14, 2021, 04:04 PM |
| Landry Robert E | EVP Finance CFO | Dec 11, 2021 | Option Exercise | $664.34 | 697 | 463,045 | 29,376 | Dec 14, 2021, 04:03 PM |
| Landry Robert E | EVP Finance CFO | Dec 10, 2021 | Option Exercise | $664.34 | 1,384 | 919,447 | 30,073 | Dec 14, 2021, 04:03 PM |
| Landry Robert E | EVP Finance CFO | Dec 10, 2021 | Option Exercise | $555.67 | 1,500 | 833,505 | 31,457 | Dec 14, 2021, 04:03 PM |
| Landry Robert E | EVP Finance CFO | Dec 13, 2021 | Sale | $662.50 | 116 | 76,850 | 29,260 | Dec 14, 2021, 04:03 PM |
| MURPHY ANDREW J | EVP Research | Dec 09, 2021 | Option Exercise | $657.11 | 9,378 | 6,162,377 | 66,289 | Dec 10, 2021, 06:42 PM |
| MURPHY ANDREW J | EVP Research | Dec 09, 2021 | Option Exercise | $52.03 | 16,500 | 858,495 | 75,667 | Dec 10, 2021, 06:42 PM |
| MURPHY ANDREW J | EVP Research | Dec 10, 2021 | Sale | $666.27 | 7,122 | 4,745,202 | 65,890 | Dec 10, 2021, 06:42 PM |
| Tessier-Lavigne Marc | Director | Dec 09, 2021 | Option Exercise | $371.40 | 3,784 | 1,405,378 | 5,862 | Dec 10, 2021, 05:41 PM |
| Tessier-Lavigne Marc | Director | Dec 09, 2021 | Sale | $665.00 | 3,784 | 2,516,360 | 2,078 | Dec 10, 2021, 05:41 PM |
| Landry Robert E | EVP Finance CFO | Dec 09, 2021 | Option Exercise | $657.11 | 3,469 | 2,279,515 | 30,738 | Dec 10, 2021, 05:37 PM |
| Landry Robert E | EVP Finance CFO | Dec 09, 2021 | Option Exercise | $399.66 | 4,250 | 1,698,555 | 34,207 | Dec 10, 2021, 05:37 PM |
| Landry Robert E | EVP Finance CFO | Dec 10, 2021 | Sale | $666.42 | 781 | 520,477 | 30,736 | Dec 10, 2021, 05:37 PM |
| LAROSA JOSEPH J | EVP General Counsel and Secret | Dec 09, 2021 | Option Exercise | $657.11 | 19,772 | 12,992,379 | 26,748 | Dec 10, 2021, 05:30 PM |
| LAROSA JOSEPH J | EVP General Counsel and Secret | Dec 09, 2021 | Option Exercise | $179.13 | 30,000 | 5,373,900 | 46,520 | Dec 10, 2021, 05:30 PM |
| STAHL NEIL | EVP Research and Development | Dec 03, 2021 | Option Exercise | $632.45 | 50,352 | 31,845,123 | 50,957 | Dec 06, 2021, 04:10 PM |
| STAHL NEIL | EVP Research and Development | Dec 03, 2021 | Option Exercise | $179.13 | 72,500 | 12,986,925 | 101,309 | Dec 06, 2021, 04:10 PM |
| RYAN ARTHUR F | Director | Dec 01, 2021 | Sale | $637.53 | 100 | 63,753 | 22,590 | Dec 02, 2021, 04:07 PM |
| McCourt Marion | EVP Commercial | Dec 01, 2021 | Option Exercise | $342.93 | 1,000 | 342,930 | 18,038 | Dec 02, 2021, 04:04 PM |
| McCourt Marion | EVP Commercial | Dec 01, 2021 | Sale | $639.13 | 1,000 | 639,130 | 17,038 | Dec 02, 2021, 04:04 PM |
| SING GEORGE L | Director | Nov 22, 2021 | Sale | $657.50 | 2,000 | 1,315,000 | 30,858 | Nov 23, 2021, 04:29 PM |
| SING GEORGE L | Director | Nov 19, 2021 | Sale | $655.00 | 1,000 | 655,000 | 31,858 | Nov 23, 2021, 04:29 PM |
| SCHLEIFER LEONARD S | President & CEO | Nov 19, 2021 | Option Exercise | $651.96 | 359,137 | 234,142,966 | 465,922 | Nov 19, 2021, 05:50 PM |
| SCHLEIFER LEONARD S | President & CEO | Nov 19, 2021 | Option Exercise | $221.08 | 520,313 | 115,030,119 | 651,568 | Nov 19, 2021, 05:50 PM |
| Landry Robert E | EVP Finance CFO | Nov 16, 2021 | Option Exercise | $651.97 | 3,069 | 2,000,896 | 26,667 | Nov 18, 2021, 04:23 PM |
| Landry Robert E | EVP Finance CFO | Nov 16, 2021 | Option Exercise | $399.66 | 3,750 | 1,498,725 | 29,736 | Nov 18, 2021, 04:23 PM |
| Landry Robert E | EVP Finance CFO | Nov 17, 2021 | Sale | $645.08 | 681 | 439,299 | 25,986 | Nov 18, 2021, 04:23 PM |
| SING GEORGE L | Director | Nov 16, 2021 | Sale | $650.00 | 750 | 487,500 | 1,000 | Nov 18, 2021, 04:09 PM |
| SING GEORGE L | Director | Nov 18, 2021 | Sale | $650.00 | 4,000 | 2,600,000 | 32,858 | Nov 18, 2021, 04:09 PM |
| SING GEORGE L | Director | Nov 16, 2021 | Sale | $656.26 | 6,000 | 3,937,580 | 40,858 | Nov 18, 2021, 04:09 PM |
| MURPHY ANDREW J | EVP Research | Nov 15, 2021 | Option Exercise | $641.50 | 9,412 | 6,037,798 | 62,872 | Nov 17, 2021, 04:04 PM |
| MURPHY ANDREW J | EVP Research | Nov 15, 2021 | Option Exercise | $52.03 | 16,579 | 862,605 | 72,284 | Nov 17, 2021, 04:04 PM |
| MURPHY ANDREW J | EVP Research | Nov 16, 2021 | Sale | $647.17 | 7,167 | 4,638,263 | 62,407 | Nov 17, 2021, 04:04 PM |
| Van Plew Daniel P | EVP & General Mgr, Industrial | Nov 15, 2021 | Option Exercise | $641.50 | 18,222 | 11,689,413 | 33,709 | Nov 17, 2021, 04:02 PM |
| Van Plew Daniel P | EVP & General Mgr, Industrial | Nov 15, 2021 | Option Exercise | $270.43 | 25,000 | 6,760,750 | 51,931 | Nov 17, 2021, 04:02 PM |
| Van Plew Daniel P | EVP & General Mgr, Industrial | Nov 16, 2021 | Sale | $656.86 | 6,778 | 4,452,194 | 33,181 | Nov 17, 2021, 04:02 PM |
| RYAN ARTHUR F | Director | Nov 01, 2021 | Sale | $642.52 | 100 | 64,252 | 23,185 | Nov 03, 2021, 04:11 PM |
| McCourt Marion | EVP Commercial | Nov 01, 2021 | Option Exercise | $342.93 | 1,000 | 342,930 | 18,038 | Nov 03, 2021, 04:09 PM |
| McCourt Marion | EVP Commercial | Nov 01, 2021 | Sale | $640.00 | 1,000 | 640,000 | 17,038 | Nov 03, 2021, 04:09 PM |
| RYAN ARTHUR F | Director | Oct 01, 2021 | Sale | $569.49 | 100 | 56,949 | 23,290 | Oct 04, 2021, 04:10 PM |
| McCourt Marion | EVP Commercial | Oct 01, 2021 | Option Exercise | $342.93 | 1,000 | 342,930 | 18,038 | Oct 04, 2021, 04:09 PM |
| McCourt Marion | EVP Commercial | Oct 01, 2021 | Sale | $576.75 | 1,000 | 576,750 | 17,038 | Oct 04, 2021, 04:09 PM |
| COLES N ANTHONY | Director | Sep 15, 2021 | Option Exercise | $365.99 | 11,948 | 4,372,807 | 12,850 | Sep 17, 2021, 04:01 PM |
| COLES N ANTHONY | Director | Sep 15, 2021 | Sale | $658.98 | 11,948 | 7,873,484 | 12,550 | Sep 17, 2021, 04:01 PM |
| BROWN MICHAEL S | Director | Sep 13, 2021 | Option Exercise | $405.06 | 9,704 | 3,930,684 | 10,595 | Sep 15, 2021, 04:03 PM |
| BROWN MICHAEL S | Director | Sep 13, 2021 | Sale | $648.16 | 9,704 | 6,289,792 | 10,495 | Sep 15, 2021, 04:03 PM |
| Zoghbi Huda Y | Director | Sep 14, 2021 | Option Exercise | $391.92 | 998 | 391,136 | 1,889 | Sep 15, 2021, 04:03 PM |
| Zoghbi Huda Y | Director | Sep 13, 2021 | Option Exercise | $391.92 | 2 | 784 | 893 | Sep 15, 2021, 04:03 PM |
| Zoghbi Huda Y | Director | Sep 14, 2021 | Sale | $650.00 | 998 | 648,700 | 891 | Sep 15, 2021, 04:03 PM |
| Zoghbi Huda Y | Director | Sep 13, 2021 | Sale | $651.10 | 2 | 1,302 | 891 | Sep 15, 2021, 04:03 PM |
| Tessier-Lavigne Marc | Director | Sep 13, 2021 | Option Exercise | $273.67 | 12,750 | 3,489,293 | 14,828 | Sep 15, 2021, 04:02 PM |
| Tessier-Lavigne Marc | Director | Sep 13, 2021 | Sale | $641.71 | 12,750 | 8,181,827 | 14,012 | Sep 15, 2021, 04:02 PM |
| GOLDSTEIN JOSEPH L | Director | Sep 10, 2021 | Option Exercise | $380.95 | 2,479 | 944,375 | 8,370 | Sep 13, 2021, 04:01 PM |
| GOLDSTEIN JOSEPH L | Director | Sep 10, 2021 | Sale | $650.00 | 2,479 | 1,611,350 | 5,891 | Sep 13, 2021, 04:01 PM |
| RYAN ARTHUR F | Director | Sep 01, 2021 | Sale | $676.28 | 100 | 67,628 | 23,381 | Sep 03, 2021, 04:04 PM |
| McCourt Marion | EVP Commercial | Sep 01, 2021 | Option Exercise | $342.93 | 1,000 | 342,930 | 18,038 | Sep 03, 2021, 04:03 PM |
| McCourt Marion | EVP Commercial | Sep 01, 2021 | Sale | $674.72 | 1,000 | 674,720 | 17,038 | Sep 03, 2021, 04:03 PM |
| Landry Robert E | EVP Finance CFO | Aug 31, 2021 | Option Exercise | $675.03 | 917 | 619,003 | 25,986 | Sep 01, 2021, 04:05 PM |
| Landry Robert E | EVP Finance CFO | Aug 31, 2021 | Option Exercise | $555.67 | 1,000 | 555,670 | 26,903 | Sep 01, 2021, 04:05 PM |
| POON CHRISTINE A | Director | Aug 27, 2021 | Option Exercise | $57.11 | 15,000 | 856,650 | 16,681 | Aug 31, 2021, 04:03 PM |
| POON CHRISTINE A | Director | Aug 27, 2021 | Sale | $668.09 | 15,000 | 10,021,406 | 16,581 | Aug 31, 2021, 04:03 PM |
| SING GEORGE L | Director | Aug 26, 2021 | Sale | $672.00 | 150 | 100,800 | 1,000 | Aug 30, 2021, 04:26 PM |
| SING GEORGE L | Director | Aug 30, 2021 | Sale | $672.50 | 1,000 | 672,500 | 43,358 | Aug 30, 2021, 04:26 PM |
| SING GEORGE L | Director | Aug 30, 2021 | Sale | $672.00 | 300 | 201,600 | 1,750 | Aug 30, 2021, 04:26 PM |
| SING GEORGE L | Director | Aug 30, 2021 | Sale | $670.00 | 250 | 167,500 | 750 | Aug 30, 2021, 04:26 PM |
| VAGELOS P ROY | Director | Aug 25, 2021 | Option Exercise | $667.39 | 49,282 | 32,890,315 | 316,808 | Aug 27, 2021, 04:01 PM |
| VAGELOS P ROY | Director | Aug 25, 2021 | Option Exercise | $179.13 | 75,000 | 13,434,750 | 366,090 | Aug 27, 2021, 04:01 PM |
| Fenimore Christopher R. | SVP Controller | Aug 20, 2021 | Option Exercise | $664.85 | 8,719 | 5,796,827 | 19,020 | Aug 25, 2021, 04:06 PM |
| LAROSA JOSEPH J | EVP General Counsel and Secret | Aug 20, 2021 | Option Exercise | $664.85 | 6,575 | 4,371,389 | 16,607 | Aug 24, 2021, 04:06 PM |
| LAROSA JOSEPH J | EVP General Counsel and Secret | Aug 20, 2021 | Option Exercise | $179.13 | 10,000 | 1,791,300 | 23,182 | Aug 24, 2021, 04:06 PM |
| LAROSA JOSEPH J | EVP General Counsel and Secret | Aug 23, 2021 | Sale | $661.84 | 3,425 | 2,266,817 | 13,224 | Aug 24, 2021, 04:06 PM |
| Fenimore Christopher R. | SVP Controller | Aug 20, 2021 | Option Exercise | $179.13 | 13,500 | 2,418,255 | 32,520 | Aug 24, 2021, 04:04 PM |
| Fenimore Christopher R. | SVP Controller | Aug 23, 2021 | Sale | $655.31 | 4,781 | 3,133,037 | 27,944 | Aug 24, 2021, 04:04 PM |
| SCHLEIFER LEONARD S | President & CEO | Aug 19, 2021 | Sale | $660.03 | 10,000 | 6,600,300 | 21,178 | Aug 20, 2021, 04:02 PM |
| SCHLEIFER LEONARD S | President & CEO | Aug 18, 2021 | Sale | $650.03 | 200,000 | 130,006,006 | 304,746 | Aug 20, 2021, 04:02 PM |
| VAGELOS P ROY | Director | Aug 18, 2021 | Sale | $650.04 | 10,039 | 6,525,751 | 37,747 | Aug 19, 2021, 04:05 PM |
| COLES N ANTHONY | Director | Aug 18, 2021 | Option Exercise | $345.47 | 5,100 | 1,761,897 | 6,002 | Aug 19, 2021, 04:04 PM |
| COLES N ANTHONY | Director | Aug 17, 2021 | Option Exercise | $345.47 | 900 | 310,923 | 1,802 | Aug 19, 2021, 04:04 PM |
| COLES N ANTHONY | Director | Aug 18, 2021 | Sale | $650.00 | 5,100 | 3,315,000 | 902 | Aug 19, 2021, 04:04 PM |
| COLES N ANTHONY | Director | Aug 17, 2021 | Sale | $650.00 | 900 | 585,000 | 902 | Aug 19, 2021, 04:04 PM |
| SCHLEIFER LEONARD S | President & CEO | Aug 16, 2021 | Sale | $624.36 | 10,000 | 6,243,614 | 41,007 | Aug 17, 2021, 04:42 PM |
| SING GEORGE L | Director | Aug 16, 2021 | Sale | $627.50 | 1,000 | 627,500 | 2,050 | Aug 17, 2021, 04:17 PM |
| SING GEORGE L | Director | Aug 16, 2021 | Sale | $630.00 | 705 | 444,150 | 43,858 | Aug 17, 2021, 04:17 PM |
| Bassler Bonnie L | Director | Aug 16, 2021 | Option Exercise | $376.69 | 1,219 | 459,185 | 2,110 | Aug 17, 2021, 04:16 PM |
| Bassler Bonnie L | Director | Aug 16, 2021 | Sale | $630.00 | 1,219 | 767,970 | 891 | Aug 17, 2021, 04:16 PM |
| YANCOPOULOS GEORGE | President and Chief Scientific | Aug 16, 2021 | Sale | $625.29 | 49,227 | 30,781,138 | 889,785 | Aug 17, 2021, 04:13 PM |
| YANCOPOULOS GEORGE | President and Chief Scientific | Aug 13, 2021 | Sale | $625.00 | 773 | 483,125 | 936,710 | Aug 17, 2021, 04:13 PM |
| COLES N ANTHONY | Director | Aug 13, 2021 | Option Exercise | $345.47 | 2,000 | 690,940 | 2,902 | Aug 16, 2021, 04:04 PM |
| COLES N ANTHONY | Director | Aug 13, 2021 | Sale | $625.00 | 2,000 | 1,250,000 | 902 | Aug 16, 2021, 04:04 PM |
| SING GEORGE L | Director | Aug 13, 2021 | Sale | $620.00 | 500 | 310,000 | 44,563 | Aug 13, 2021, 05:19 PM |
| SING GEORGE L | Director | Aug 12, 2021 | Sale | $611.00 | 1,000 | 611,000 | 45,063 | Aug 13, 2021, 05:19 PM |
| SING GEORGE L | Director | Aug 11, 2021 | Sale | $620.50 | 2,000 | 1,241,000 | 47,063 | Aug 13, 2021, 05:19 PM |
| SING GEORGE L | Director | Aug 11, 2021 | Sale | $620.00 | 300 | 186,000 | 3,050 | Aug 13, 2021, 05:19 PM |
| Landry Robert E | EVP Finance CFO | Aug 09, 2021 | Option Exercise | $617.68 | 2,463 | 1,521,346 | 26,440 | Aug 10, 2021, 05:55 PM |
| Landry Robert E | EVP Finance CFO | Aug 06, 2021 | Option Exercise | $607.51 | 1,636 | 993,886 | 26,267 | Aug 10, 2021, 05:55 PM |
| Landry Robert E | EVP Finance CFO | Aug 09, 2021 | Option Exercise | $381.92 | 3,000 | 1,145,760 | 28,903 | Aug 10, 2021, 05:55 PM |
| Landry Robert E | EVP Finance CFO | Aug 06, 2021 | Option Exercise | $381.92 | 2,000 | 763,840 | 27,903 | Aug 10, 2021, 05:55 PM |
| Landry Robert E | EVP Finance CFO | Aug 10, 2021 | Sale | $611.90 | 537 | 328,593 | 26,007 | Aug 10, 2021, 05:55 PM |
| Landry Robert E | EVP Finance CFO | Aug 09, 2021 | Sale | $617.83 | 364 | 224,891 | 26,266 | Aug 10, 2021, 05:55 PM |
| Van Plew Daniel P | EVP & General Mgr, Industrial | Aug 09, 2021 | Option Exercise | $617.68 | 18,397 | 11,363,459 | 33,534 | Aug 10, 2021, 05:54 PM |
| Van Plew Daniel P | EVP & General Mgr, Industrial | Aug 09, 2021 | Option Exercise | $270.43 | 25,000 | 6,760,750 | 51,931 | Aug 10, 2021, 05:54 PM |
| Van Plew Daniel P | EVP & General Mgr, Industrial | Aug 10, 2021 | Sale | $611.86 | 6,603 | 4,040,105 | 33,290 | Aug 10, 2021, 05:54 PM |
| SCHLEIFER LEONARD S | President & CEO | Aug 06, 2021 | Option Exercise | $607.51 | 228,575 | 138,861,600 | 504,746 | Aug 10, 2021, 05:05 PM |
| SCHLEIFER LEONARD S | President & CEO | Aug 06, 2021 | Option Exercise | $52.03 | 400,000 | 20,812,000 | 596,176 | Aug 10, 2021, 05:05 PM |
| BROWN MICHAEL S | Director | Aug 09, 2021 | Sale | $612.38 | 1,687 | 1,033,085 | 7,662 | Aug 10, 2021, 05:00 PM |
| SING GEORGE L | Director | Aug 06, 2021 | Sale | $612.42 | 350 | 214,347 | 3,350 | Aug 10, 2021, 05:00 PM |
| SING GEORGE L | Director | Aug 10, 2021 | Sale | $613.85 | 2,600 | 1,596,010 | 50,063 | Aug 10, 2021, 05:00 PM |
| SING GEORGE L | Director | Aug 06, 2021 | Sale | $611.38 | 4,000 | 2,445,520 | 51,663 | Aug 10, 2021, 05:00 PM |
| YANCOPOULOS GEORGE | President and Chief Scientific | Aug 05, 2021 | Sale | $600.06 | 50,000 | 30,003,000 | 937,483 | Aug 06, 2021, 04:03 PM |
| Bassler Bonnie L | Director | Aug 05, 2021 | Option Exercise | $391.92 | 2,559 | 1,002,923 | 3,450 | Aug 06, 2021, 04:02 PM |
| Bassler Bonnie L | Director | Aug 05, 2021 | Sale | $600.00 | 2,559 | 1,535,400 | 891 | Aug 06, 2021, 04:02 PM |
| RYAN ARTHUR F | Director | Aug 02, 2021 | Sale | $577.95 | 100 | 57,795 | 23,489 | Aug 04, 2021, 04:05 PM |
| McCourt Marion | EVP Commercial | Aug 02, 2021 | Option Exercise | $342.93 | 1,000 | 342,930 | 18,038 | Aug 04, 2021, 04:03 PM |
| McCourt Marion | EVP Commercial | Aug 02, 2021 | Sale | $577.12 | 1,000 | 577,120 | 17,038 | Aug 04, 2021, 04:03 PM |
| LAROSA JOSEPH J | EVP General Counsel and Secret | Jul 02, 2021 | Option Exercise | $582.20 | 6,602 | 3,843,684 | 16,580 | Jul 07, 2021, 04:01 PM |
| LAROSA JOSEPH J | EVP General Counsel and Secret | Jul 02, 2021 | Option Exercise | $179.13 | 10,000 | 1,791,300 | 23,182 | Jul 07, 2021, 04:01 PM |
| LAROSA JOSEPH J | EVP General Counsel and Secret | Jul 06, 2021 | Sale | $580.00 | 3,398 | 1,970,840 | 13,182 | Jul 07, 2021, 04:01 PM |
| McCourt Marion | EVP Commercial | Jul 01, 2021 | Option Exercise | $342.93 | 1,000 | 342,930 | 18,038 | Jul 02, 2021, 04:02 PM |
| McCourt Marion | EVP Commercial | Jul 01, 2021 | Sale | $556.60 | 1,000 | 556,600 | 17,038 | Jul 02, 2021, 04:02 PM |
| RYAN ARTHUR F | Director | Jul 01, 2021 | Sale | $564.50 | 100 | 56,450 | 23,589 | Jul 02, 2021, 04:02 PM |
| BROWN MICHAEL S | Director | Jun 25, 2021 | Option Exercise | $371.40 | 2,084 | 773,998 | 2,975 | Jun 28, 2021, 04:01 PM |
| BROWN MICHAEL S | Director | Jun 25, 2021 | Sale | $549.00 | 2,084 | 1,144,116 | 891 | Jun 28, 2021, 04:01 PM |
| YANCOPOULOS GEORGE | President and Chief Scientific | Jun 21, 2021 | Sale | $538.90 | 80,000 | 43,112,140 | 81,370 | Jun 23, 2021, 04:02 PM |
| GOLDSTEIN JOSEPH L | Director | Jun 07, 2021 | Option Exercise | $374.12 | 1,930 | 722,052 | 7,821 | Jun 08, 2021, 04:03 PM |
| GOLDSTEIN JOSEPH L | Director | Jun 07, 2021 | Sale | $525.00 | 1,930 | 1,013,250 | 5,891 | Jun 08, 2021, 04:03 PM |
| McCourt Marion | EVP Commercial | Jun 07, 2021 | Option Exercise | $342.93 | 1,000 | 342,930 | 18,038 | Jun 08, 2021, 04:02 PM |
| McCourt Marion | EVP Commercial | Jun 07, 2021 | Sale | $511.65 | 1,000 | 511,650 | 17,038 | Jun 08, 2021, 04:02 PM |
| VAGELOS P ROY | Director | Feb 23, 2021 | Option Exercise | $458.48 | 137,998 | 63,269,325 | 349,090 | Feb 24, 2021, 12:00 AM |
| VAGELOS P ROY | Director | Feb 23, 2021 | Option Exercise | $52.03 | 250,000 | 13,007,500 | 487,088 | Feb 24, 2021, 12:00 AM |
| RYAN ARTHUR F | Director | Feb 01, 2021 | Sale | $506.92 | 100 | 50,692 | 23,782 | Feb 02, 2021, 04:06 PM |
| BROWN MICHAEL S | Director | Jan 25, 2021 | Option Exercise | $380.95 | 2,480 | 944,756 | 3,371 | Jan 27, 2021, 04:06 PM |
| BROWN MICHAEL S | Director | Jan 25, 2021 | Sale | $554.32 | 2,480 | 1,374,714 | 891 | Jan 27, 2021, 04:06 PM |
| RYAN ARTHUR F | Director | Jan 04, 2021 | Sale | $483.60 | 100 | 48,360 | 23,639 | Jan 05, 2021, 04:09 PM |
| YANCOPOULOS GEORGE | President and Chief Scientific | Dec 30, 2020 | Option Exercise | $483.25 | 216,810 | 104,773,433 | 822,207 | Dec 31, 2020, 05:30 PM |
| YANCOPOULOS GEORGE | President and Chief Scientific | Dec 30, 2020 | Option Exercise | $52.03 | 398,079 | 20,712,050 | 908,303 | Dec 31, 2020, 05:30 PM |
| RYAN ARTHUR F | Director | Dec 01, 2020 | Sale | $520.48 | 100 | 52,048 | 23,741 | Dec 02, 2020, 04:09 PM |
| MURPHY ANDREW J | EVP Research | Nov 16, 2020 | Option Exercise | $561.39 | 7,108 | 3,990,360 | 53,764 | Nov 18, 2020, 04:02 PM |
| MURPHY ANDREW J | EVP Research | Nov 16, 2020 | Option Exercise | $30.63 | 13,736 | 420,734 | 60,872 | Nov 18, 2020, 04:02 PM |
| MURPHY ANDREW J | EVP Research | Nov 17, 2020 | Sale | $542.73 | 6,628 | 3,597,188 | 53,021 | Nov 18, 2020, 04:02 PM |
| COLES N ANTHONY | Director | Nov 13, 2020 | Option Exercise | $345.47 | 11 | 3,800 | 654 | Nov 13, 2020, 05:57 PM |
| RYAN ARTHUR F | Director | Nov 02, 2020 | Sale | $548.54 | 100 | 54,854 | 23,823 | Nov 03, 2020, 05:22 PM |
| MURPHY ANDREW J | EVP Research | Oct 22, 2020 | Option Exercise | $38.56 | 5,185 | 199,926 | 47,136 | Oct 23, 2020, 04:02 PM |
| GOLDSTEIN JOSEPH L | Director | Oct 05, 2020 | Option Exercise | $520.01 | 9,212 | 4,790,332 | 14,855 | Oct 06, 2020, 04:09 PM |
| GOLDSTEIN JOSEPH L | Director | Oct 05, 2020 | Sale | $600.00 | 9,212 | 5,527,200 | 5,643 | Oct 06, 2020, 04:09 PM |
| McCourt Marion | SVP Commercial | Oct 05, 2020 | Option Exercise | $342.93 | 1,000 | 342,930 | 14,963 | Oct 06, 2020, 04:07 PM |
| McCourt Marion | SVP Commercial | Aug 20, 2020 | Option Exercise | $342.93 | 1,000 | 342,930 | 14,963 | Oct 06, 2020, 04:07 PM |
| McCourt Marion | SVP Commercial | Oct 05, 2020 | Sale | $600.00 | 1,000 | 600,000 | 13,963 | Oct 06, 2020, 04:07 PM |
| McCourt Marion | SVP Commercial | Aug 20, 2020 | Sale | $612.15 | 1,000 | 612,150 | 13,963 | Oct 06, 2020, 04:07 PM |
| RYAN ARTHUR F | Director | Oct 01, 2020 | Sale | $558.13 | 100 | 55,813 | 28,441 | Oct 05, 2020, 04:13 PM |
| BROWN MICHAEL S | Director | Sep 22, 2020 | Option Exercise | $378.77 | 5,090 | 1,927,917 | 5,733 | Sep 23, 2020, 04:01 PM |
| BROWN MICHAEL S | Director | Sep 22, 2020 | Sale | $552.36 | 1,000 | 552,360 | 9,349 | Sep 23, 2020, 04:01 PM |
| BROWN MICHAEL S | Director | Sep 22, 2020 | Sale | $552.36 | 5,090 | 2,811,512 | 643 | Sep 23, 2020, 04:01 PM |
| GOLDSTEIN JOSEPH L | Director | Sep 21, 2020 | Option Exercise | $376.76 | 16,574 | 6,244,372 | 22,217 | Sep 23, 2020, 04:00 PM |
| GOLDSTEIN JOSEPH L | Director | Sep 22, 2020 | Sale | $552.36 | 20 | 11,047 | 5,643 | Sep 23, 2020, 04:00 PM |
| GOLDSTEIN JOSEPH L | Director | Sep 21, 2020 | Sale | $549.86 | 16,554 | 9,102,447 | 21,917 | Sep 23, 2020, 04:00 PM |
| RYAN ARTHUR F | Director | Sep 01, 2020 | Sale | $604.58 | 100 | 60,458 | 28,523 | Sep 03, 2020, 04:18 PM |
| LAROSA JOSEPH J | EVP General Counsel and Secret | Aug 27, 2020 | Option Exercise | $614.87 | 5,328 | 3,276,027 | 19,110 | Aug 31, 2020, 04:37 PM |
| LAROSA JOSEPH J | EVP General Counsel and Secret | Aug 27, 2020 | Option Exercise | $52.03 | 10,000 | 520,300 | 21,241 | Aug 31, 2020, 04:37 PM |
| LAROSA JOSEPH J | EVP General Counsel and Secret | Aug 31, 2020 | Sale | $615.04 | 4,672 | 2,873,467 | 14,438 | Aug 31, 2020, 04:37 PM |
| SING GEORGE L | Director | Aug 31, 2020 | Sale | $612.06 | 10,000 | 6,120,555 | 60,815 | Aug 31, 2020, 04:36 PM |
| POON CHRISTINE A | Director | Aug 28, 2020 | Option Exercise | $28.44 | 40,000 | 1,137,550 | 41,433 | Aug 31, 2020, 04:35 PM |
| POON CHRISTINE A | Director | Aug 28, 2020 | Sale | $601.22 | 40,000 | 24,048,715 | 41,256 | Aug 31, 2020, 04:35 PM |
| SING GEORGE L | Director | Aug 25, 2020 | Option Exercise | $273.67 | 12,750 | 3,489,293 | 97,165 | Aug 27, 2020, 04:23 PM |
| SING GEORGE L | Director | Aug 25, 2020 | Sale | $612.00 | 1,000 | 612,000 | 3,700 | Aug 27, 2020, 04:23 PM |
| SING GEORGE L | Director | Aug 25, 2020 | Sale | $607.28 | 32,750 | 19,888,518 | 95,765 | Aug 27, 2020, 04:23 PM |
| Van Plew Daniel P | EVP & General Mgr Industrial O | Aug 25, 2020 | Sale | $610.89 | 27,109 | 16,560,738 | 36,854 | Aug 27, 2020, 04:21 PM |
| SING GEORGE L | Director | Aug 24, 2020 | Option Exercise | $177.82 | 10,037 | 1,784,779 | 104,452 | Aug 24, 2020, 06:13 PM |
| SING GEORGE L | Director | Aug 21, 2020 | Option Exercise | $117.24 | 9,963 | 1,168,071 | 114,078 | Aug 24, 2020, 06:13 PM |
| SING GEORGE L | Director | Aug 20, 2020 | Option Exercise | $57.11 | 10,000 | 571,100 | 114,415 | Aug 24, 2020, 06:13 PM |
| SING GEORGE L | Director | Aug 21, 2020 | Sale | $605.12 | 19,963 | 12,080,039 | 109,078 | Aug 24, 2020, 06:13 PM |
| SING GEORGE L | Director | Aug 20, 2020 | Sale | $616.91 | 21,000 | 12,955,042 | 111,632 | Aug 24, 2020, 06:13 PM |
| SING GEORGE L | Director | Aug 24, 2020 | Sale | $593.63 | 20,037 | 11,894,577 | 103,251 | Aug 24, 2020, 06:13 PM |
| GOLDSTEIN JOSEPH L | Director | Aug 21, 2020 | Sale | $617.18 | 1,000 | 617,180 | 5,643 | Aug 24, 2020, 05:19 PM |
| Van Plew Daniel P | EVP & General Mgr Industrial O | Aug 20, 2020 | Option Exercise | $614.09 | 47,891 | 29,409,385 | 47,110 | Aug 24, 2020, 04:47 PM |
| Van Plew Daniel P | EVP & General Mgr Industrial O | Aug 20, 2020 | Option Exercise | $179.13 | 75,000 | 13,434,750 | 95,001 | Aug 24, 2020, 04:47 PM |
| VAGELOS P ROY | Director | Aug 11, 2020 | Sale | $602.94 | 33,460 | 20,174,355 | 83,572 | Aug 13, 2020, 04:02 PM |
| RYAN ARTHUR F | Director | Aug 03, 2020 | Sale | $641.93 | 100 | 64,193 | 28,640 | Aug 05, 2020, 05:09 PM |
| Landry Robert E | EVP Finance CFO | Aug 04, 2020 | Sale | $654.46 | 696 | 455,504 | 23,973 | Aug 05, 2020, 05:07 PM |
| Fenimore Christopher R. | VP Controller | Jul 20, 2020 | Option Exercise | $655.57 | 6,291 | 4,124,191 | 18,986 | Jul 22, 2020, 04:31 PM |
| Fenimore Christopher R. | VP Controller | Jul 20, 2020 | Option Exercise | $156.01 | 12,224 | 1,907,015 | 25,277 | Jul 22, 2020, 04:31 PM |
| Fenimore Christopher R. | VP Controller | Jul 21, 2020 | Sale | $642.04 | 3,709 | 2,381,317 | 20,994 | Jul 22, 2020, 04:31 PM |
| Landry Robert E | EVP Finance CFO | Jul 20, 2020 | Option Exercise | $655.57 | 7,413 | 4,859,740 | 25,060 | Jul 22, 2020, 04:30 PM |
| Landry Robert E | EVP Finance CFO | Jul 20, 2020 | Option Exercise | $491.43 | 8,500 | 4,177,160 | 29,671 | Jul 22, 2020, 04:30 PM |
| Landry Robert E | EVP Finance CFO | Jul 21, 2020 | Sale | $647.58 | 391 | 253,204 | 24,672 | Jul 22, 2020, 04:30 PM |
| MURPHY ANDREW J | EVP Research | Jul 14, 2020 | Sale | $633.48 | 2,380 | 1,507,677 | 44,067 | Jul 15, 2020, 04:51 PM |
| MURPHY ANDREW J | EVP Research | Jul 13, 2020 | Option Exercise | $623.98 | 6,691 | 4,175,050 | 48,260 | Jul 15, 2020, 04:51 PM |
| MURPHY ANDREW J | EVP Research | Jul 13, 2020 | Option Exercise | $30.63 | 13,000 | 398,190 | 54,951 | Jul 15, 2020, 04:51 PM |
| MURPHY ANDREW J | EVP Research | Jul 13, 2020 | Sale | $628.50 | 8,000 | 5,028,022 | 49,855 | Jul 15, 2020, 04:51 PM |
| MURPHY ANDREW J | EVP Research | Jul 14, 2020 | Sale | $623.89 | 3,929 | 2,451,277 | 48,082 | Jul 15, 2020, 04:51 PM |
| Landry Robert E | EVP Finance CFO | Jul 14, 2020 | Sale | $640.50 | 579 | 370,850 | 23,973 | Jul 14, 2020, 04:17 PM |
| Landry Robert E | EVP Finance CFO | Jul 09, 2020 | Option Exercise | $642.46 | 2,421 | 1,555,396 | 24,552 | Jul 13, 2020, 04:28 PM |
| Landry Robert E | EVP Finance CFO | Jul 09, 2020 | Option Exercise | $399.66 | 3,000 | 1,198,980 | 26,973 | Jul 13, 2020, 04:28 PM |
| Landry Robert E | EVP Finance CFO | Jul 07, 2020 | Option Exercise | $640.88 | 11,340 | 7,267,579 | 25,133 | Jul 09, 2020, 04:29 PM |
| Landry Robert E | EVP Finance CFO | Jul 07, 2020 | Option Exercise | $524.47 | 12,500 | 6,555,850 | 33,973 | Jul 09, 2020, 04:29 PM |
| Landry Robert E | EVP Finance CFO | Jul 08, 2020 | Sale | $639.66 | 1,160 | 742,011 | 25,109 | Jul 09, 2020, 04:29 PM |
| SING GEORGE L | Director | Jul 07, 2020 | Option Exercise | $33.42 | 7,500 | 250,650 | 122,915 | Jul 08, 2020, 04:16 PM |
| SING GEORGE L | Director | Jul 07, 2020 | Sale | $650.00 | 500 | 325,000 | 1,150 | Jul 08, 2020, 04:16 PM |
| SING GEORGE L | Director | Jul 07, 2020 | Sale | $650.00 | 7,500 | 4,875,000 | 115,415 | Jul 08, 2020, 04:16 PM |
| SING GEORGE L | Director | Jul 07, 2020 | Sale | $650.00 | 1,500 | 975,000 | 4,700 | Jul 08, 2020, 04:16 PM |
| SING GEORGE L | Director | Jul 07, 2020 | Sale | $650.47 | 1,000 | 650,474 | 600 | Jul 08, 2020, 04:16 PM |
| Zoghbi Huda Y | Director | Jul 07, 2020 | Option Exercise | $391.92 | 1,706 | 668,616 | 2,349 | Jul 08, 2020, 04:14 PM |
| Zoghbi Huda Y | Director | Jul 07, 2020 | Sale | $650.00 | 1,706 | 1,108,900 | 643 | Jul 08, 2020, 04:14 PM |
| BROWN MICHAEL S | Director | Jul 01, 2020 | Option Exercise | $413.33 | 3,613 | 1,493,361 | 4,256 | Jul 02, 2020, 04:02 PM |
| BROWN MICHAEL S | Director | Jul 01, 2020 | Sale | $607.62 | 3,613 | 2,195,342 | 4,156 | Jul 02, 2020, 04:02 PM |
| RYAN ARTHUR F | Director | Jul 01, 2020 | Sale | $609.70 | 100 | 60,970 | 28,739 | Jul 02, 2020, 04:01 PM |
| Landry Robert E | EVP Finance CFO | Jun 29, 2020 | Sale | $612.57 | 400 | 245,029 | 24,334 | Jun 30, 2020, 04:02 PM |
| SING GEORGE L | Director | Jun 29, 2020 | Sale | $607.98 | 1,000 | 607,981 | 2,200 | Jun 29, 2020, 04:08 PM |
| SING GEORGE L | Director | Jun 29, 2020 | Sale | $609.37 | 500 | 304,685 | 1,650 | Jun 29, 2020, 04:08 PM |
| SING GEORGE L | Director | Jun 29, 2020 | Sale | $609.37 | 1,500 | 914,055 | 6,200 | Jun 29, 2020, 04:08 PM |
| Landry Robert E | EVP Finance CFO | Jun 22, 2020 | Option Exercise | $626.19 | 8,388 | 5,252,482 | 24,885 | Jun 24, 2020, 04:03 PM |
| Landry Robert E | EVP Finance CFO | Jun 22, 2020 | Option Exercise | $555.67 | 8,900 | 4,945,463 | 33,273 | Jun 24, 2020, 04:03 PM |
| Landry Robert E | EVP Finance CFO | Jun 23, 2020 | Sale | $631.27 | 512 | 323,212 | 24,845 | Jun 24, 2020, 04:03 PM |
| Bassler Bonnie L | Director | Jun 19, 2020 | Option Exercise | $391.92 | 2,559 | 1,002,923 | 3,202 | Jun 22, 2020, 04:18 PM |
| Bassler Bonnie L | Director | Jun 19, 2020 | Sale | $630.02 | 2,559 | 1,612,211 | 654 | Jun 22, 2020, 04:18 PM |
| Fenimore Christopher R. | VP Controller | Jun 15, 2020 | Option Exercise | $587.90 | 3,670 | 2,157,593 | 16,653 | Jun 17, 2020, 04:02 PM |
| Fenimore Christopher R. | VP Controller | Jun 15, 2020 | Option Exercise | $47.07 | 9,406 | 442,742 | 20,323 | Jun 17, 2020, 04:02 PM |
| Fenimore Christopher R. | VP Controller | Jun 16, 2020 | Sale | $590.89 | 3,556 | 2,101,215 | 18,721 | Jun 17, 2020, 04:02 PM |
| Zoghbi Huda Y | Director | Jun 10, 2020 | Option Exercise | $391.92 | 1,706 | 668,616 | 2,349 | Jun 12, 2020, 04:03 PM |
| Zoghbi Huda Y | Director | Jun 11, 2020 | Option Exercise | $391.92 | 1,706 | 668,616 | 2,349 | Jun 12, 2020, 04:03 PM |
| Zoghbi Huda Y | Director | Jun 10, 2020 | Sale | $610.24 | 1,706 | 1,041,068 | 2,200 | Jun 12, 2020, 04:03 PM |
| Zoghbi Huda Y | Director | Jun 11, 2020 | Sale | $625.00 | 1,706 | 1,066,250 | 643 | Jun 12, 2020, 04:03 PM |
| Landry Robert E | EVP Finance CFO | Jun 10, 2020 | Option Exercise | $610.18 | 2,512 | 1,532,772 | 25,361 | Jun 12, 2020, 04:01 PM |
| Landry Robert E | EVP Finance CFO | Jun 10, 2020 | Option Exercise | $272.70 | 3,500 | 954,450 | 27,873 | Jun 12, 2020, 04:01 PM |
| Landry Robert E | EVP Finance CFO | Jun 11, 2020 | Sale | $612.08 | 988 | 604,731 | 24,916 | Jun 12, 2020, 04:01 PM |
| Sanofi | 10% Owner | Jun 09, 2020 | Sale | $597.48 | 120,234 | 71,837,408 | 279,766 | Jun 11, 2020, 06:45 PM |
| Landry Robert E | EVP Finance CFO | Jun 08, 2020 | Option Exercise | $592.43 | 11,229 | 6,652,342 | 28,644 | Jun 10, 2020, 04:04 PM |
| Landry Robert E | EVP Finance CFO | Jun 08, 2020 | Option Exercise | $272.70 | 15,500 | 4,226,850 | 29,860 | Jun 10, 2020, 04:04 PM |
| Landry Robert E | EVP Finance CFO | Jun 09, 2020 | Sale | $608.01 | 4,271 | 2,596,792 | 28,534 | Jun 10, 2020, 04:04 PM |
| GOLDSTEIN JOSEPH L | Director | Jun 08, 2020 | Option Exercise | $413.33 | 10,838 | 4,479,670 | 17,481 | Jun 09, 2020, 04:05 PM |
| GOLDSTEIN JOSEPH L | Director | Jun 08, 2020 | Sale | $592.95 | 10,838 | 6,426,362 | 17,381 | Jun 09, 2020, 04:05 PM |
| Bassler Bonnie L | Director | Jun 05, 2020 | Option Exercise | $391.92 | 2,559 | 1,002,923 | 3,202 | Jun 05, 2020, 04:15 PM |
| Bassler Bonnie L | Director | Jun 05, 2020 | Sale | $600.00 | 2,559 | 1,535,400 | 643 | Jun 05, 2020, 04:15 PM |
| RYAN ARTHUR F | Director | Jun 01, 2020 | Sale | $603.23 | 100 | 60,323 | 28,838 | Jun 02, 2020, 04:04 PM |
| SING GEORGE L | Director | May 29, 2020 | Sale | $595.00 | 500 | 297,500 | 7,700 | Jun 01, 2020, 04:08 PM |
| SING GEORGE L | Director | May 28, 2020 | Sale | $578.00 | 500 | 289,000 | 8,200 | Jun 01, 2020, 04:08 PM |
| SING GEORGE L | Director | May 29, 2020 | Sale | $598.02 | 500 | 299,010 | 2,400 | Jun 01, 2020, 04:08 PM |
| SING GEORGE L | Director | May 28, 2020 | Sale | $580.00 | 500 | 290,000 | 2,900 | Jun 01, 2020, 04:08 PM |
| GOLDSTEIN JOSEPH L | Director | May 28, 2020 | Sale | $578.94 | 1,000 | 578,940 | 6,643 | Jun 01, 2020, 04:02 PM |
| Sanofi | 10% Owner | May 29, 2020 | Sale | $509.85 | 20,421,899 | 10,412,105,330 | 0 | May 29, 2020, 04:16 PM |
| Sanofi | 10% Owner | May 29, 2020 | Sale | $509.85 | 2,399,552 | 1,223,411,602 | 400,000 | May 29, 2020, 04:16 PM |
| VAGELOS P ROY | Chairman of the Board | May 21, 2020 | Sale | $577.49 | 783 | 452,178 | 307,849 | May 22, 2020, 06:21 PM |
| VAGELOS P ROY | Chairman of the Board | May 20, 2020 | Option Exercise | $570.97 | 159,642 | 91,150,788 | 457,343 | May 22, 2020, 06:21 PM |
| VAGELOS P ROY | Chairman of the Board | May 20, 2020 | Option Exercise | $30.63 | 312,500 | 9,571,875 | 497,063 | May 22, 2020, 06:21 PM |
| VAGELOS P ROY | Chairman of the Board | May 21, 2020 | Sale | $564.37 | 148,811 | 83,984,786 | 456,175 | May 22, 2020, 06:21 PM |
| LAROSA JOSEPH J | EVP General Counsel and Secret | May 14, 2020 | Option Exercise | $573.18 | 9,931 | 5,692,251 | 22,818 | May 15, 2020, 04:03 PM |
| LAROSA JOSEPH J | EVP General Counsel and Secret | May 14, 2020 | Option Exercise | $59.20 | 18,311 | 1,084,011 | 32,749 | May 15, 2020, 04:03 PM |
| LAROSA JOSEPH J | EVP General Counsel and Secret | May 15, 2020 | Sale | $572.00 | 8,380 | 4,793,360 | 14,438 | May 15, 2020, 04:03 PM |
| SCHLEIFER LEONARD S | President & CEO | May 11, 2020 | Option Exercise | $571.43 | 161,578 | 92,330,515 | 625,421 | May 13, 2020, 09:01 PM |
| SCHLEIFER LEONARD S | President & CEO | May 11, 2020 | Option Exercise | $30.63 | 312,500 | 9,571,875 | 722,368 | May 13, 2020, 09:01 PM |
| SCHLEIFER LEONARD S | President & CEO | May 12, 2020 | Sale | $569.22 | 150,922 | 85,908,042 | 623,092 | May 13, 2020, 09:01 PM |
| SING GEORGE L | Director | May 13, 2020 | Option Exercise | $33.42 | 5,000 | 167,100 | 120,415 | May 13, 2020, 09:00 PM |
| SING GEORGE L | Director | May 11, 2020 | Sale | $575.00 | 300 | 172,500 | 8,700 | May 13, 2020, 09:00 PM |
| SING GEORGE L | Director | May 11, 2020 | Sale | $575.00 | 300 | 172,500 | 3,400 | May 13, 2020, 09:00 PM |
| SING GEORGE L | Director | May 11, 2020 | Sale | $575.00 | 250 | 143,750 | 2,150 | May 13, 2020, 09:00 PM |
| SING GEORGE L | Director | May 13, 2020 | Sale | $580.00 | 5,000 | 2,900,000 | 115,415 | May 13, 2020, 09:00 PM |
| STAHL NEIL | EVP Research and Development | May 08, 2020 | Option Exercise | $560.67 | 7,195 | 4,034,021 | 16,685 | May 11, 2020, 04:39 PM |
| STAHL NEIL | EVP Research and Development | May 08, 2020 | Option Exercise | $52.03 | 12,500 | 650,375 | 23,880 | May 11, 2020, 04:39 PM |
| STAHL NEIL | EVP Research and Development | May 11, 2020 | Sale | $569.52 | 5,305 | 3,021,289 | 16,373 | May 11, 2020, 04:39 PM |
| Van Plew Daniel P | EVP & General Mgr Industrial O | May 06, 2020 | Option Exercise | $555.77 | 45,996 | 25,563,198 | 67,834 | May 08, 2020, 04:04 PM |
| Van Plew Daniel P | EVP & General Mgr Industrial O | May 06, 2020 | Option Exercise | $52.03 | 85,579 | 4,452,675 | 96,051 | May 08, 2020, 04:04 PM |
| Van Plew Daniel P | EVP & General Mgr Industrial O | May 07, 2020 | Sale | $564.32 | 39,583 | 22,337,306 | 67,734 | May 08, 2020, 04:04 PM |
| Tessier-Lavigne Marc | Director | May 06, 2020 | Option Exercise | $177.82 | 15,000 | 2,667,300 | 16,830 | May 08, 2020, 04:03 PM |
| Tessier-Lavigne Marc | Director | May 06, 2020 | Sale | $563.97 | 15,000 | 8,459,496 | 15,805 | May 08, 2020, 04:03 PM |
| Zoghbi Huda Y | Director | May 07, 2020 | Option Exercise | $391.92 | 5,118 | 2,005,847 | 5,761 | May 08, 2020, 04:03 PM |
| Zoghbi Huda Y | Director | May 07, 2020 | Sale | $566.52 | 5,118 | 2,899,461 | 4,039 | May 08, 2020, 04:03 PM |
| RYAN ARTHUR F | Director | May 06, 2020 | Option Exercise | $373.67 | 50,124 | 18,729,670 | 78,967 | May 07, 2020, 06:22 PM |
| RYAN ARTHUR F | Director | May 06, 2020 | Sale | $550.88 | 50,124 | 27,612,508 | 78,966 | May 07, 2020, 06:22 PM |
| BROWN MICHAEL S | Director | May 06, 2020 | Option Exercise | $555.77 | 3,661 | 2,034,674 | 2,452 | May 07, 2020, 04:14 PM |
| BROWN MICHAEL S | Director | May 06, 2020 | Option Exercise | $371.98 | 5,470 | 2,034,739 | 5,863 | May 07, 2020, 04:14 PM |
| BROWN MICHAEL S | Director | May 07, 2020 | Sale | $562.00 | 1,809 | 1,016,658 | 643 | May 07, 2020, 04:14 PM |
| GOLDSTEIN JOSEPH L | Director | May 06, 2020 | Sale | $560.00 | 2,000 | 1,120,000 | 7,643 | May 06, 2020, 04:19 PM |
| RYAN ARTHUR F | Director | May 01, 2020 | Sale | $520.37 | 100 | 52,037 | 28,931 | May 04, 2020, 04:02 PM |
| Landry Robert E | EVP Finance CFO | Apr 17, 2020 | Option Exercise | $555.82 | 9,250 | 5,141,335 | 27,623 | Apr 20, 2020, 07:29 PM |
| Landry Robert E | EVP Finance CFO | Apr 16, 2020 | Option Exercise | $529.79 | 3,009 | 1,594,138 | 25,364 | Apr 20, 2020, 07:29 PM |
| Landry Robert E | EVP Finance CFO | Apr 17, 2020 | Option Exercise | $272.70 | 12,500 | 3,408,750 | 36,873 | Apr 20, 2020, 07:29 PM |
| Landry Robert E | EVP Finance CFO | Apr 16, 2020 | Option Exercise | $272.70 | 4,000 | 1,090,800 | 28,373 | Apr 20, 2020, 07:29 PM |
| Landry Robert E | EVP Finance CFO | Apr 20, 2020 | Sale | $566.94 | 3,250 | 1,842,539 | 27,588 | Apr 20, 2020, 07:29 PM |
| Landry Robert E | EVP Finance CFO | Apr 17, 2020 | Sale | $557.68 | 991 | 552,661 | 25,331 | Apr 20, 2020, 07:29 PM |
| LAROSA JOSEPH J | EVP General Counsel and Secret | Apr 20, 2020 | Sale | $570.30 | 1,778 | 1,013,985 | 15,547 | Apr 20, 2020, 07:27 PM |
| LAROSA JOSEPH J | EVP General Counsel and Secret | Apr 17, 2020 | Option Exercise | $555.82 | 6,322 | 3,513,894 | 19,738 | Apr 20, 2020, 07:26 PM |
| LAROSA JOSEPH J | EVP General Counsel and Secret | Apr 16, 2020 | Option Exercise | $529.79 | 2,733 | 1,447,916 | 16,705 | Apr 20, 2020, 07:26 PM |
| LAROSA JOSEPH J | EVP General Counsel and Secret | Apr 16, 2020 | Option Exercise | $59.20 | 5,000 | 296,000 | 19,438 | Apr 20, 2020, 07:26 PM |
| LAROSA JOSEPH J | EVP General Counsel and Secret | Apr 17, 2020 | Option Exercise | $59.20 | 11,622 | 688,022 | 22,458 | Apr 20, 2020, 07:26 PM |
| LAROSA JOSEPH J | EVP General Counsel and Secret | Apr 20, 2020 | Sale | $565.48 | 3,522 | 1,991,611 | 19,687 | Apr 20, 2020, 07:26 PM |
| LAROSA JOSEPH J | EVP General Counsel and Secret | Apr 17, 2020 | Sale | $557.38 | 2,267 | 1,263,586 | 16,610 | Apr 20, 2020, 07:26 PM |
| LAROSA JOSEPH J | EVP General Counsel and Secret | Apr 14, 2020 | Option Exercise | $521.45 | 2,738 | 1,427,730 | 16,700 | Apr 16, 2020, 04:04 PM |
| LAROSA JOSEPH J | EVP General Counsel and Secret | Apr 14, 2020 | Option Exercise | $59.20 | 5,000 | 296,000 | 19,438 | Apr 16, 2020, 04:04 PM |
| LAROSA JOSEPH J | EVP General Counsel and Secret | Apr 15, 2020 | Sale | $518.21 | 2,262 | 1,172,187 | 16,608 | Apr 16, 2020, 04:04 PM |
| Landry Robert E | EVP Finance CFO | Apr 14, 2020 | Option Exercise | $521.45 | 2,647 | 1,380,278 | 25,226 | Apr 16, 2020, 04:03 PM |
| Landry Robert E | EVP Finance CFO | Apr 14, 2020 | Option Exercise | $272.70 | 3,500 | 954,450 | 27,873 | Apr 16, 2020, 04:03 PM |
| Landry Robert E | EVP Finance CFO | Apr 15, 2020 | Sale | $518.49 | 853 | 442,276 | 25,172 | Apr 16, 2020, 04:03 PM |
| STAHL NEIL | EVP Research and Development | Apr 13, 2020 | Option Exercise | $511.56 | 7,582 | 3,878,648 | 16,877 | Apr 15, 2020, 04:17 PM |
| STAHL NEIL | EVP Research and Development | Apr 13, 2020 | Option Exercise | $52.03 | 13,079 | 680,500 | 24,459 | Apr 15, 2020, 04:17 PM |
| STAHL NEIL | EVP Research and Development | Apr 14, 2020 | Sale | $521.07 | 5,497 | 2,864,307 | 16,875 | Apr 15, 2020, 04:17 PM |
| Landry Robert E | EVP Finance CFO | Apr 09, 2020 | Option Exercise | $508.25 | 2,672 | 1,358,044 | 25,201 | Apr 13, 2020, 07:23 PM |
| Landry Robert E | EVP Finance CFO | Apr 09, 2020 | Option Exercise | $272.70 | 3,500 | 954,450 | 27,873 | Apr 13, 2020, 07:23 PM |
| Landry Robert E | EVP Finance CFO | Apr 13, 2020 | Sale | $509.79 | 828 | 422,108 | 25,102 | Apr 13, 2020, 07:23 PM |
| Landry Robert E | EVP Finance CFO | Apr 06, 2020 | Option Exercise | $499.95 | 2,304 | 1,151,885 | 25,069 | Apr 08, 2020, 04:02 PM |
| Landry Robert E | EVP Finance CFO | Apr 06, 2020 | Option Exercise | $272.70 | 3,000 | 818,100 | 27,373 | Apr 08, 2020, 04:02 PM |
| Landry Robert E | EVP Finance CFO | Apr 07, 2020 | Sale | $497.52 | 696 | 346,271 | 24,375 | Apr 08, 2020, 04:02 PM |
| Landry Robert E | EVP Finance CFO | Apr 03, 2020 | Sale | $494.28 | 683 | 337,592 | 24,935 | Apr 03, 2020, 04:50 PM |
| Landry Robert E | EVP Finance CFO | Apr 02, 2020 | Sale | $495.88 | 105 | 52,068 | 25,092 | Apr 03, 2020, 04:50 PM |
| Landry Robert E | EVP Finance CFO | Apr 02, 2020 | Option Exercise | $492.05 | 2,317 | 1,140,080 | 26,409 | Apr 03, 2020, 04:49 PM |
| Landry Robert E | EVP Finance CFO | Apr 01, 2020 | Option Exercise | $488.22 | 4,647 | 2,268,735 | 25,726 | Apr 03, 2020, 04:49 PM |
| Landry Robert E | EVP Finance CFO | Apr 02, 2020 | Option Exercise | $272.70 | 3,000 | 818,100 | 28,726 | Apr 03, 2020, 04:49 PM |
| Landry Robert E | EVP Finance CFO | Apr 01, 2020 | Option Exercise | $272.70 | 6,000 | 1,636,200 | 26,937 | Apr 03, 2020, 04:49 PM |
| Landry Robert E | EVP Finance CFO | Apr 01, 2020 | Sale | $488.02 | 600 | 292,811 | 24,950 | Apr 03, 2020, 04:49 PM |
| Landry Robert E | EVP Finance CFO | Apr 02, 2020 | Sale | $489.32 | 1,248 | 610,672 | 26,270 | Apr 03, 2020, 04:49 PM |
| LAROSA JOSEPH J | EVP General Counsel and Secret | Apr 01, 2020 | Option Exercise | $488.22 | 8,203 | 4,004,869 | 21,235 | Apr 03, 2020, 04:08 PM |
| LAROSA JOSEPH J | EVP General Counsel and Secret | Apr 01, 2020 | Option Exercise | $59.20 | 15,000 | 888,000 | 23,924 | Apr 03, 2020, 04:08 PM |
| LAROSA JOSEPH J | EVP General Counsel and Secret | Apr 02, 2020 | Sale | $489.98 | 6,797 | 3,330,406 | 21,043 | Apr 03, 2020, 04:08 PM |
| Fenimore Christopher R. | VP Controller | Apr 01, 2020 | Option Exercise | $30.63 | 1,200 | 36,756 | 14,297 | Apr 03, 2020, 04:05 PM |
| Fenimore Christopher R. | VP Controller | Apr 01, 2020 | Sale | $488.41 | 1,200 | 586,096 | 14,234 | Apr 03, 2020, 04:05 PM |
| RYAN ARTHUR F | Director | Apr 01, 2020 | Sale | $483.85 | 100 | 48,385 | 29,041 | Apr 01, 2020, 06:49 PM |
| RYAN ARTHUR F | Director | Mar 30, 2020 | Sale | $466.69 | 100 | 46,669 | 29,141 | Apr 01, 2020, 06:49 PM |
| Sanofi | 10% Owner | Mar 09, 2020 | Sale | $489.65 | 128,914 | 63,123,129 | 20,421,899 | Mar 11, 2020, 05:00 PM |
| YANCOPOULOS GEORGE | President and Chief Scientific | Mar 09, 2020 | Option Exercise | $476.42 | 128,921 | 61,420,545 | 635,614 | Mar 11, 2020, 04:05 PM |
| YANCOPOULOS GEORGE | President and Chief Scientific | Mar 09, 2020 | Option Exercise | $30.63 | 246,736 | 7,557,523 | 713,990 | Mar 11, 2020, 04:05 PM |
| YANCOPOULOS GEORGE | President and Chief Scientific | Mar 10, 2020 | Sale | $470.47 | 117,815 | 55,428,041 | 634,455 | Mar 11, 2020, 04:05 PM |
| GOLDSTEIN JOSEPH L | Director | Mar 09, 2020 | Option Exercise | $33.42 | 2,000 | 66,840 | 11,643 | Mar 10, 2020, 04:05 PM |
| GOLDSTEIN JOSEPH L | Director | Mar 09, 2020 | Sale | $475.84 | 2,000 | 951,684 | 11,443 | Mar 10, 2020, 04:05 PM |
| STAHL NEIL | EVP Research and Development | Feb 26, 2020 | Option Exercise | $451.89 | 14,651 | 6,620,641 | 21,729 | Feb 28, 2020, 04:40 PM |
| STAHL NEIL | EVP Research and Development | Feb 26, 2020 | Option Exercise | $52.03 | 25,000 | 1,300,750 | 36,380 | Feb 28, 2020, 04:40 PM |
| STAHL NEIL | EVP Research and Development | Feb 27, 2020 | Sale | $452.26 | 10,349 | 4,680,460 | 21,520 | Feb 28, 2020, 04:40 PM |
| SING GEORGE L | Director | Feb 26, 2020 | Option Exercise | $33.42 | 2,500 | 83,550 | 117,915 | Feb 28, 2020, 04:30 PM |
| SING GEORGE L | Director | Feb 26, 2020 | Sale | $452.50 | 1,000 | 452,500 | 9,500 | Feb 28, 2020, 04:30 PM |
| SING GEORGE L | Director | Feb 26, 2020 | Sale | $453.50 | 800 | 362,800 | 4,100 | Feb 28, 2020, 04:30 PM |
| SING GEORGE L | Director | Feb 26, 2020 | Sale | $452.50 | 600 | 271,500 | 2,700 | Feb 28, 2020, 04:30 PM |
| SING GEORGE L | Director | Feb 26, 2020 | Sale | $460.00 | 2,500 | 1,150,000 | 115,415 | Feb 28, 2020, 04:30 PM |
| Van Plew Daniel P | EVP & General Mgr Industrial O | Feb 25, 2020 | Option Exercise | $447.30 | 17,093 | 7,645,699 | 43,893 | Feb 27, 2020, 04:12 PM |
| Van Plew Daniel P | EVP & General Mgr Industrial O | Feb 25, 2020 | Option Exercise | $30.63 | 32,735 | 1,002,673 | 60,986 | Feb 27, 2020, 04:12 PM |
| Van Plew Daniel P | EVP & General Mgr Industrial O | Feb 26, 2020 | Sale | $457.23 | 15,642 | 7,152,016 | 43,693 | Feb 27, 2020, 04:12 PM |
| Landry Robert E | EVP Finance CFO | Feb 24, 2020 | Option Exercise | $406.59 | 786 | 319,580 | 25,187 | Feb 26, 2020, 06:14 PM |
| Landry Robert E | EVP Finance CFO | Feb 25, 2020 | Option Exercise | $447.30 | 800 | 357,840 | 25,387 | Feb 26, 2020, 06:14 PM |
| Landry Robert E | EVP Finance CFO | Feb 24, 2020 | Option Exercise | $272.70 | 1,000 | 272,700 | 25,973 | Feb 26, 2020, 06:14 PM |
| Landry Robert E | EVP Finance CFO | Feb 25, 2020 | Option Exercise | $272.70 | 1,000 | 272,700 | 26,187 | Feb 26, 2020, 06:14 PM |
| Landry Robert E | EVP Finance CFO | Feb 26, 2020 | Sale | $456.21 | 200 | 91,242 | 25,163 | Feb 26, 2020, 06:14 PM |
| Landry Robert E | EVP Finance CFO | Feb 25, 2020 | Sale | $449.01 | 214 | 96,088 | 25,377 | Feb 26, 2020, 06:14 PM |
| YANCOPOULOS GEORGE | President and Chief Scientific | Feb 24, 2020 | Sale | $420.17 | 118,123 | 49,631,742 | 517,799 | Feb 25, 2020, 04:05 PM |
| BROWN MICHAEL S | Director | Feb 24, 2020 | Option Exercise | $273.67 | 2,000 | 547,340 | 2,643 | Feb 25, 2020, 04:03 PM |
| BROWN MICHAEL S | Director | Feb 24, 2020 | Sale | $419.00 | 2,000 | 838,001 | 687 | Feb 25, 2020, 04:03 PM |
| Tessier-Lavigne Marc | Director | Feb 13, 2020 | Option Exercise | $53.08 | 14,279 | 757,944 | 11,109 | Feb 14, 2020, 04:10 PM |
| Tessier-Lavigne Marc | Director | Feb 13, 2020 | Sale | $400.01 | 14,279 | 5,711,711 | 10,472 | Feb 14, 2020, 04:10 PM |
| Landry Robert E | EVP Finance CFO | Feb 12, 2020 | Option Exercise | $402.34 | 393 | 158,120 | 25,080 | Feb 14, 2020, 04:10 PM |
| Landry Robert E | EVP Finance CFO | Feb 12, 2020 | Option Exercise | $272.70 | 500 | 136,350 | 25,473 | Feb 14, 2020, 04:10 PM |
| Landry Robert E | EVP Finance CFO | Feb 13, 2020 | Sale | $400.05 | 107 | 42,806 | 25,033 | Feb 14, 2020, 04:10 PM |
| STAHL NEIL | EVP Research and Development | Feb 12, 2020 | Option Exercise | $402.34 | 14,722 | 5,923,249 | 21,658 | Feb 14, 2020, 04:09 PM |
| STAHL NEIL | EVP Research and Development | Feb 12, 2020 | Option Exercise | $52.03 | 25,000 | 1,300,750 | 36,380 | Feb 14, 2020, 04:09 PM |
| STAHL NEIL | EVP Research and Development | Feb 13, 2020 | Sale | $400.66 | 10,278 | 4,117,958 | 17,356 | Feb 14, 2020, 04:09 PM |
| GOLDSTEIN JOSEPH L | Director | Feb 07, 2020 | Sale | $382.83 | 1,000 | 382,830 | 9,643 | Feb 10, 2020, 04:45 PM |
| MURPHY ANDREW J | EVP Research | Jan 27, 2020 | Sale | $340.91 | 8,000 | 2,727,279 | 57,751 | Jan 28, 2020, 05:06 PM |
| Fenimore Christopher R. | VP Controller | Jan 24, 2020 | Option Exercise | $30.63 | 500 | 15,315 | 13,097 | Jan 27, 2020, 04:04 PM |
| SING GEORGE L | Director | Jan 02, 2020 | Option Exercise | $24.41 | 15,000 | 366,150 | 130,095 | Jan 06, 2020, 04:02 PM |
| SING GEORGE L | Director | Jan 02, 2020 | Sale | $371.98 | 15,000 | 5,579,700 | 115,095 | Jan 06, 2020, 04:02 PM |
| Fenimore Christopher R. | VP Controller | Dec 20, 2019 | Option Exercise | $30.63 | 400 | 12,252 | 12,597 | Dec 23, 2019, 04:02 PM |
| VAGELOS P ROY | Chairman of the Board | Dec 16, 2019 | Option Exercise | $375.31 | 126 | 47,289 | 2,200 | Dec 18, 2019, 04:05 PM |
| Fenimore Christopher R. | VP Controller | Dec 12, 2019 | Option Exercise | $377.16 | 1,418 | 534,813 | 13,879 | Dec 13, 2019, 06:03 PM |
| Fenimore Christopher R. | VP Controller | Dec 12, 2019 | Option Exercise | $52.03 | 3,100 | 161,293 | 15,297 | Dec 13, 2019, 06:03 PM |
| Fenimore Christopher R. | VP Controller | Dec 13, 2019 | Sale | $376.14 | 1,682 | 632,665 | 13,688 | Dec 13, 2019, 06:03 PM |
| VAGELOS P ROY | Chairman of the Board | Dec 12, 2019 | Option Exercise | $377.16 | 55,813 | 21,050,431 | 356,327 | Dec 13, 2019, 05:43 PM |
| VAGELOS P ROY | Chairman of the Board | Dec 12, 2019 | Option Exercise | $21.25 | 107,655 | 2,287,669 | 412,140 | Dec 13, 2019, 05:43 PM |
| VAGELOS P ROY | Chairman of the Board | Dec 13, 2019 | Sale | $376.04 | 51,842 | 19,494,488 | 355,695 | Dec 13, 2019, 05:43 PM |
| YANCOPOULOS GEORGE | President and CSO | Dec 12, 2019 | Option Exercise | $377.16 | 127,172 | 47,964,192 | 444,109 | Dec 13, 2019, 04:44 PM |
| YANCOPOULOS GEORGE | President and CSO | Dec 12, 2019 | Option Exercise | $21.25 | 245,295 | 5,212,519 | 521,876 | Dec 13, 2019, 04:44 PM |
| BROWN MICHAEL S | Director | Dec 13, 2019 | Option Exercise | $273.67 | 4,000 | 1,094,680 | 4,323 | Dec 13, 2019, 04:07 PM |
| BROWN MICHAEL S | Director | Dec 13, 2019 | Sale | $373.99 | 4,000 | 1,495,968 | 3,308 | Dec 13, 2019, 04:07 PM |
| SCHLEIFER LEONARD S | President & CEO | Dec 12, 2019 | Option Exercise | $377.16 | 161,963 | 61,085,966 | 474,499 | Dec 13, 2019, 04:05 PM |
| SCHLEIFER LEONARD S | President & CEO | Dec 12, 2019 | Option Exercise | $21.25 | 312,400 | 6,638,500 | 571,708 | Dec 13, 2019, 04:05 PM |
| GOLDSTEIN JOSEPH L | Director | Nov 27, 2019 | Option Exercise | $33.42 | 1,000 | 33,420 | 11,323 | Dec 02, 2019, 04:03 PM |
| GOLDSTEIN JOSEPH L | Director | Nov 27, 2019 | Sale | $370.00 | 1,000 | 370,000 | 10,323 | Dec 02, 2019, 04:03 PM |
| STAHL NEIL | EVP Research and Development | Nov 25, 2019 | Option Exercise | $362.75 | 5,994 | 2,174,324 | 26,461 | Nov 26, 2019, 04:29 PM |
| STAHL NEIL | EVP Research and Development | Nov 25, 2019 | Option Exercise | $52.03 | 10,000 | 520,300 | 32,455 | Nov 26, 2019, 04:29 PM |
| STAHL NEIL | EVP Research and Development | Nov 26, 2019 | Sale | $364.07 | 4,006 | 1,458,467 | 25,039 | Nov 26, 2019, 04:29 PM |
| VAGELOS P ROY | Chairman of the Board | Nov 22, 2019 | Option Exercise | $358.33 | 23,989 | 8,595,978 | 362,727 | Nov 26, 2019, 04:02 PM |
| VAGELOS P ROY | Chairman of the Board | Nov 22, 2019 | Option Exercise | $21.25 | 46,138 | 980,433 | 386,716 | Nov 26, 2019, 04:02 PM |
| VAGELOS P ROY | Chairman of the Board | Nov 25, 2019 | Sale | $363.87 | 22,149 | 8,059,412 | 326,478 | Nov 26, 2019, 04:02 PM |
| GOLDSTEIN JOSEPH L | Director | Nov 22, 2019 | Option Exercise | $33.42 | 1,000 | 33,420 | 11,323 | Nov 22, 2019, 04:07 PM |
| GOLDSTEIN JOSEPH L | Director | Nov 21, 2019 | Option Exercise | $33.42 | 1,000 | 33,420 | 11,323 | Nov 22, 2019, 04:07 PM |
| GOLDSTEIN JOSEPH L | Director | Nov 22, 2019 | Sale | $360.00 | 1,000 | 360,000 | 10,323 | Nov 22, 2019, 04:07 PM |
| GOLDSTEIN JOSEPH L | Director | Nov 21, 2019 | Sale | $350.00 | 1,000 | 350,000 | 10,323 | Nov 22, 2019, 04:07 PM |
| BROWN MICHAEL S | Director | Nov 12, 2019 | Option Exercise | $273.67 | 4,500 | 1,231,515 | 4,823 | Nov 13, 2019, 04:11 PM |
| BROWN MICHAEL S | Director | Nov 12, 2019 | Sale | $349.00 | 4,500 | 1,570,500 | 323 | Nov 13, 2019, 04:11 PM |
| STAHL NEIL | EVP Research and Development | Nov 08, 2019 | Sale | $338.52 | 7,364 | 2,492,888 | 29,719 | Nov 12, 2019, 04:05 PM |
| GOLDSTEIN JOSEPH L | Director | Nov 08, 2019 | Sale | $340.44 | 1,000 | 340,440 | 10,323 | Nov 08, 2019, 05:02 PM |
| Sanofi | 10% Owner | Sep 10, 2019 | Sale | $281.15 | 172,904 | 48,611,784 | 20,550,813 | Sep 12, 2019, 05:00 PM |
| VAGELOS P ROY | Chairman of the Board | May 24, 2019 | Option Exercise | $313.64 | 80,164 | 25,142,638 | 388,505 | May 29, 2019, 04:16 PM |
| VAGELOS P ROY | Chairman of the Board | May 24, 2019 | Option Exercise | $21.25 | 153,792 | 3,268,080 | 468,669 | May 29, 2019, 04:16 PM |
| GOLDSTEIN JOSEPH L | Director | May 15, 2019 | Sale | $305.93 | 1,000 | 305,930 | 11,323 | May 15, 2019, 08:42 PM |
| STAHL NEIL | EVP Research and Development | May 13, 2019 | Option Exercise | $304.20 | 15,147 | 4,607,718 | 32,303 | May 15, 2019, 04:02 PM |
| STAHL NEIL | EVP Research and Development | May 13, 2019 | Option Exercise | $52.03 | 25,000 | 1,300,750 | 47,450 | May 15, 2019, 04:02 PM |
| STAHL NEIL | EVP Research and Development | May 14, 2019 | Sale | $305.74 | 9,853 | 3,012,483 | 25,728 | May 15, 2019, 04:02 PM |
| Fenimore Christopher R. | VP Controller | Apr 18, 2019 | Option Exercise | $21.25 | 350 | 7,438 | 7,446 | Apr 18, 2019, 07:04 PM |
| SCHLEIFER LEONARD S | President & CEO | Mar 21, 2019 | Option Exercise | $21.25 | 100 | 2,125 | 424,062 | Mar 22, 2019, 04:03 PM |
| Sanofi | 10% Owner | Mar 08, 2019 | Sale | $412.17 | 131,115 | 54,041,275 | 20,723,717 | Mar 12, 2019, 08:19 PM |
| Fenimore Christopher R. | VP Controller | Jan 18, 2019 | Option Exercise | $21.25 | 150 | 3,188 | 7,246 | Jan 18, 2019, 05:01 PM |
| GOLDSTEIN JOSEPH L | Director | Jan 10, 2019 | Option Exercise | $273.67 | 1,791 | 490,143 | 14,114 | Jan 11, 2019, 04:06 PM |
| GOLDSTEIN JOSEPH L | Director | Jan 10, 2019 | Sale | $410.00 | 1,791 | 734,310 | 12,323 | Jan 11, 2019, 04:06 PM |
| Fenimore Christopher R. | VP Controller | Dec 19, 2018 | Option Exercise | $364.42 | 1,602 | 583,801 | 8,269 | Dec 20, 2018, 05:36 PM |
| Fenimore Christopher R. | VP Controller | Dec 20, 2018 | Option Exercise | $21.25 | 675 | 14,344 | 8,944 | Dec 20, 2018, 05:36 PM |
| Fenimore Christopher R. | VP Controller | Dec 19, 2018 | Option Exercise | $52.03 | 3,450 | 179,503 | 9,871 | Dec 20, 2018, 05:36 PM |
| Fenimore Christopher R. | VP Controller | Dec 20, 2018 | Sale | $358.97 | 1,848 | 663,381 | 8,844 | Dec 20, 2018, 05:36 PM |
| YANCOPOULOS GEORGE | President and Chief Scientific | Dec 13, 2018 | Option Exercise | $377.31 | 125,055 | 47,184,502 | 118,993 | Dec 17, 2018, 04:02 PM |
| YANCOPOULOS GEORGE | President and Chief Scientific | Dec 13, 2018 | Option Exercise | $16.80 | 244,048 | 4,100,006 | 167,185 | Dec 17, 2018, 04:02 PM |
| VAGELOS P ROY | Chairman of the Board | Dec 12, 2018 | Sale | $382.32 | 6 | 2,294 | 2,304 | Dec 14, 2018, 04:49 PM |
| SCHLEIFER LEONARD S | President & CEO | Dec 13, 2018 | Option Exercise | $377.31 | 160,131 | 60,419,027 | 423,962 | Dec 14, 2018, 04:19 PM |
| SCHLEIFER LEONARD S | President & CEO | Dec 13, 2018 | Option Exercise | $16.80 | 312,500 | 5,250,000 | 488,014 | Dec 14, 2018, 04:19 PM |
| GOLDSTEIN JOSEPH L | Director | Sep 28, 2018 | Option Exercise | $273.67 | 709 | 194,032 | 12,709 | Oct 01, 2018, 04:06 PM |
| GOLDSTEIN JOSEPH L | Director | Sep 27, 2018 | Option Exercise | $273.67 | 2,000 | 547,340 | 14,000 | Oct 01, 2018, 04:06 PM |
| GOLDSTEIN JOSEPH L | Director | Sep 27, 2018 | Sale | $400.00 | 2,000 | 800,000 | 12,000 | Oct 01, 2018, 04:06 PM |
| GOLDSTEIN JOSEPH L | Director | Sep 28, 2018 | Sale | $410.00 | 709 | 290,690 | 12,000 | Oct 01, 2018, 04:06 PM |
| BROWN MICHAEL S | Director | Sep 27, 2018 | Option Exercise | $273.67 | 2,000 | 547,340 | 2,000 | Sep 28, 2018, 04:35 PM |
| BROWN MICHAEL S | Director | Sep 27, 2018 | Sale | $392.26 | 2,000 | 784,524 | 1,611 | Sep 28, 2018, 04:35 PM |
| GOLDSTEIN JOSEPH L | Director | Sep 24, 2018 | Option Exercise | $273.67 | 2,000 | 547,340 | 13,000 | Sep 25, 2018, 04:05 PM |
| GOLDSTEIN JOSEPH L | Director | Sep 24, 2018 | Sale | $388.65 | 2,000 | 777,290 | 12,000 | Sep 25, 2018, 04:05 PM |
| Sanofi | 10% Owner | Sep 06, 2018 | Sale | $406.68 | 104,552 | 42,519,207 | 23,654,384 | Sep 10, 2018, 05:01 PM |
| Fenimore Christopher R. | VP Controller | Aug 30, 2018 | Option Exercise | $21.25 | 50 | 1,063 | 200 | Aug 31, 2018, 04:02 PM |
| BROWN MICHAEL S | Director | Aug 22, 2018 | Option Exercise | $177.82 | 1,500 | 266,730 | 1,500 | Aug 23, 2018, 04:01 PM |
| BROWN MICHAEL S | Director | Aug 22, 2018 | Sale | $380.49 | 1,500 | 570,735 | 0 | Aug 23, 2018, 04:01 PM |
| VAGELOS P ROY | Chairman of the Board | Aug 20, 2018 | Option Exercise | $374.46 | 108 | 40,442 | 399,949 | Aug 21, 2018, 04:55 PM |
| VAGELOS P ROY | Chairman of the Board | Aug 20, 2018 | Option Exercise | $21.25 | 210 | 4,463 | 400,057 | Aug 21, 2018, 04:55 PM |
| GOLDSTEIN JOSEPH L | Director | Aug 02, 2018 | Option Exercise | $57.11 | 2,000 | 114,220 | 14,000 | Aug 03, 2018, 04:03 PM |
| GOLDSTEIN JOSEPH L | Director | Aug 02, 2018 | Sale | $380.00 | 2,000 | 760,000 | 12,000 | Aug 03, 2018, 04:03 PM |
| VAGELOS P ROY | Chairman of the Board | Jul 09, 2018 | Option Exercise | $370.52 | 78,604 | 29,124,353 | 474,517 | Jul 11, 2018, 04:04 PM |
| VAGELOS P ROY | Chairman of the Board | Jul 09, 2018 | Option Exercise | $16.80 | 153,274 | 2,575,003 | 553,121 | Jul 11, 2018, 04:04 PM |
| VAGELOS P ROY | Chairman of the Board | Jul 10, 2018 | Sale | $367.22 | 74,670 | 27,420,277 | 473,617 | Jul 11, 2018, 04:04 PM |
| GOLDSTEIN JOSEPH L | Director | Jul 05, 2018 | Option Exercise | $57.11 | 2,000 | 114,220 | 14,000 | Jul 09, 2018, 04:04 PM |
| GOLDSTEIN JOSEPH L | Director | Jul 06, 2018 | Option Exercise | $57.11 | 2,000 | 114,220 | 14,000 | Jul 09, 2018, 04:04 PM |
| GOLDSTEIN JOSEPH L | Director | Jul 05, 2018 | Sale | $360.00 | 2,000 | 720,000 | 12,000 | Jul 09, 2018, 04:04 PM |
| GOLDSTEIN JOSEPH L | Director | Jul 06, 2018 | Sale | $370.00 | 2,000 | 740,000 | 12,000 | Jul 09, 2018, 04:04 PM |
| VAGELOS P ROY | Chairman of the Board | Jun 20, 2018 | Option Exercise | $333.07 | 78,564 | 26,167,312 | 474,557 | Jun 22, 2018, 04:03 PM |
| VAGELOS P ROY | Chairman of the Board | Jun 20, 2018 | Option Exercise | $16.80 | 153,274 | 2,575,003 | 553,121 | Jun 22, 2018, 04:03 PM |
| VAGELOS P ROY | Chairman of the Board | Jun 21, 2018 | Sale | $327.87 | 74,710 | 24,495,410 | 474,157 | Jun 22, 2018, 04:03 PM |
| Sanofi | 10% Owner | Jun 08, 2018 | Sale | $309.31 | 121,601 | 37,611,919 | 23,758,936 | Jun 11, 2018, 04:30 PM |
| STAHL NEIL | EVP Research and Development | May 23, 2018 | Option Exercise | $293.68 | 15,329 | 4,501,821 | 43,380 | May 25, 2018, 04:03 PM |
| STAHL NEIL | EVP Research and Development | May 23, 2018 | Option Exercise | $30.63 | 26,736 | 818,924 | 58,709 | May 25, 2018, 04:03 PM |
| STAHL NEIL | EVP Research and Development | May 24, 2018 | Sale | $295.09 | 11,407 | 3,366,092 | 31,973 | May 25, 2018, 04:03 PM |
| SING GEORGE L | Director | May 10, 2018 | Sale | $286.62 | 13,000 | 3,726,000 | 124,772 | May 11, 2018, 04:02 PM |
| SING GEORGE L | Director | May 09, 2018 | Sale | $285.29 | 7,000 | 1,997,030 | 127,772 | May 11, 2018, 04:02 PM |
| GOLDSTEIN JOSEPH L | Director | Mar 19, 2018 | Option Exercise | $57.11 | 2,000 | 114,220 | 14,000 | Mar 19, 2018, 04:47 PM |
| GOLDSTEIN JOSEPH L | Director | Mar 19, 2018 | Sale | $350.02 | 2,000 | 700,040 | 12,000 | Mar 19, 2018, 04:47 PM |
| GOLDSTEIN JOSEPH L | Director | Mar 14, 2018 | Option Exercise | $57.11 | 2,000 | 114,220 | 14,000 | Mar 14, 2018, 04:01 PM |
| GOLDSTEIN JOSEPH L | Director | Mar 14, 2018 | Sale | $340.00 | 2,000 | 680,000 | 12,000 | Mar 14, 2018, 04:01 PM |
| GOLDSTEIN JOSEPH L | Director | Feb 09, 2018 | Sale | $325.60 | 1,000 | 325,600 | 12,000 | Feb 13, 2018, 04:01 PM |
| Fenimore Christopher R. | VP Controller | Jan 16, 2018 | Option Exercise | $21.25 | 150 | 3,188 | 150 | Jan 17, 2018, 04:07 PM |
| SING GEORGE L | Director | Jan 02, 2018 | Option Exercise | $23.84 | 15,000 | 357,600 | 134,772 | Jan 03, 2018, 12:00 AM |
| YANCOPOULOS GEORGE | President & CSO | Dec 18, 2017 | Option Exercise | $386.90 | 257,850 | 99,762,163 | 422,762 | Dec 20, 2017, 04:05 PM |
| SCHLEIFER LEONARD S | President & CEO | Dec 13, 2017 | Option Exercise | $385.08 | 135,816 | 52,300,023 | 393,179 | Dec 13, 2017, 05:17 PM |
| SCHLEIFER LEONARD S | President & CEO | Dec 13, 2017 | Option Exercise | $21.92 | 250,000 | 5,480,000 | 407,409 | Dec 13, 2017, 05:17 PM |
| YANCOPOULOS GEORGE | President & CSO | Dec 13, 2017 | Option Exercise | $385.08 | 106,174 | 40,885,482 | 775,662 | Dec 13, 2017, 05:17 PM |
| YANCOPOULOS GEORGE | President & CSO | Dec 13, 2017 | Option Exercise | $21.92 | 195,438 | 4,284,001 | 786,786 | Dec 13, 2017, 05:17 PM |
| VAGELOS P ROY | Chairman of the Board | Dec 11, 2017 | Option Exercise | $383.29 | 83,665 | 32,067,959 | 474,707 | Dec 13, 2017, 04:53 PM |
| VAGELOS P ROY | Chairman of the Board | Dec 11, 2017 | Option Exercise | $21.92 | 153,969 | 3,375,000 | 483,512 | Dec 13, 2017, 04:53 PM |
| BROWN MICHAEL S | Director | Oct 05, 2017 | Option Exercise | $177.82 | 1,500 | 266,730 | 1,500 | Oct 05, 2017, 04:18 PM |
| BROWN MICHAEL S | Director | Oct 05, 2017 | Sale | $475.00 | 1,500 | 712,500 | 0 | Oct 05, 2017, 04:18 PM |
| BAKER CHARLES A | Director | Sep 29, 2017 | Option Exercise | $18.61 | 2,000 | 37,220 | 11,000 | Oct 03, 2017, 12:00 AM |
| BAKER CHARLES A | Director | Sep 29, 2017 | Sale | $450.00 | 2,000 | 900,000 | 9,000 | Oct 03, 2017, 12:00 AM |
| Landry Robert E | SVP Finance & CFO | Sep 01, 2017 | Option Exercise | $501.29 | 2,337 | 1,171,515 | 8,468 | Sep 06, 2017, 05:06 PM |
| Landry Robert E | SVP Finance & CFO | Sep 01, 2017 | Option Exercise | $272.70 | 3,000 | 818,100 | 10,099 | Sep 06, 2017, 05:06 PM |
| Landry Robert E | SVP Finance & CFO | Sep 06, 2017 | Sale | $497.62 | 474 | 235,873 | 7,473 | Sep 06, 2017, 05:06 PM |
| Landry Robert E | SVP Finance & CFO | Sep 05, 2017 | Sale | $501.06 | 189 | 94,700 | 7,662 | Sep 06, 2017, 05:06 PM |
| Landry Robert E | SVP Finance & CFO | Aug 30, 2017 | Option Exercise | $486.91 | 1,573 | 765,909 | 7,980 | Sep 01, 2017, 04:04 PM |
| Landry Robert E | SVP Finance & CFO | Aug 30, 2017 | Option Exercise | $272.70 | 2,000 | 545,400 | 9,099 | Sep 01, 2017, 04:04 PM |
| Landry Robert E | SVP Finance & CFO | Aug 31, 2017 | Sale | $493.43 | 427 | 210,693 | 7,426 | Sep 01, 2017, 04:04 PM |
| Sanofi | 10% Owner | Aug 25, 2017 | Buy | $481.36 | 72,378 | 34,840,125 | 23,880,537 | Aug 29, 2017, 05:00 PM |
| Sanofi | 10% Owner | Aug 24, 2017 | Buy | $482.04 | 105,820 | 51,009,566 | 23,808,159 | Aug 25, 2017, 05:00 PM |
| Sanofi | 10% Owner | Aug 23, 2017 | Buy | $478.98 | 60,595 | 29,024,042 | 23,702,339 | Aug 25, 2017, 05:00 PM |
| Landry Robert E | SVP Finance & CFO | Aug 22, 2017 | Option Exercise | $476.10 | 1,532 | 729,385 | 7,955 | Aug 24, 2017, 04:47 PM |
| Landry Robert E | SVP Finance & CFO | Aug 22, 2017 | Option Exercise | $272.70 | 2,000 | 545,400 | 9,099 | Aug 24, 2017, 04:47 PM |
| Landry Robert E | SVP Finance & CFO | Aug 23, 2017 | Sale | $476.45 | 468 | 222,981 | 7,467 | Aug 24, 2017, 04:47 PM |
| VAGELOS P ROY | Chairman of the Board | Aug 22, 2017 | Sale | $477.64 | 31,944 | 15,257,816 | 361,087 | Aug 23, 2017, 04:21 PM |
| VAGELOS P ROY | Chairman of the Board | Aug 21, 2017 | Sale | $470.32 | 24,269 | 11,414,076 | 363,638 | Aug 23, 2017, 04:21 PM |
| VAGELOS P ROY | Chairman of the Board | Aug 16, 2017 | Option Exercise | $471.41 | 82,565 | 38,921,967 | 476,353 | Aug 18, 2017, 05:00 PM |
| VAGELOS P ROY | Chairman of the Board | Aug 16, 2017 | Option Exercise | $21.92 | 153,969 | 3,375,000 | 483,512 | Aug 18, 2017, 05:00 PM |
| VAGELOS P ROY | Chairman of the Board | Aug 17, 2017 | Sale | $470.00 | 1,305 | 613,350 | 388,656 | Aug 18, 2017, 05:00 PM |
| VAGELOS P ROY | Chairman of the Board | Aug 16, 2017 | Sale | $470.17 | 10,986 | 5,165,288 | 389,961 | Aug 18, 2017, 05:00 PM |
| VAGELOS P ROY | Chairman of the Board | Aug 18, 2017 | Sale | $470.15 | 2,900 | 1,363,435 | 385,756 | Aug 18, 2017, 05:00 PM |
| Terifay Robert J | EVP Commercial | Aug 10, 2017 | Option Exercise | $52.03 | 1,921 | 99,950 | 25,214 | Aug 11, 2017, 04:02 PM |
| Landry Robert E | SVP Finance & CFO | Aug 07, 2017 | Option Exercise | $466.98 | 1,474 | 688,329 | 7,932 | Aug 09, 2017, 04:03 PM |
| Landry Robert E | SVP Finance & CFO | Aug 07, 2017 | Option Exercise | $272.70 | 2,000 | 545,400 | 9,099 | Aug 09, 2017, 04:03 PM |
| Landry Robert E | SVP Finance & CFO | Aug 08, 2017 | Sale | $472.19 | 526 | 248,372 | 7,525 | Aug 09, 2017, 04:03 PM |
| Aberman Michael S | SVP Strategy Investor Relation | Jun 21, 2017 | Option Exercise | $510.02 | 2,231 | 1,137,855 | 8,923 | Jun 23, 2017, 04:10 PM |
| Aberman Michael S | SVP Strategy Investor Relation | Jun 21, 2017 | Option Exercise | $30.63 | 4,500 | 137,835 | 9,193 | Jun 23, 2017, 04:10 PM |
| Aberman Michael S | SVP Strategy Investor Relation | Jun 22, 2017 | Sale | $532.42 | 2,269 | 1,208,061 | 6,567 | Jun 23, 2017, 04:10 PM |
| STAHL NEIL | EVP Research and Development | Jun 21, 2017 | Option Exercise | $510.02 | 11,694 | 5,964,174 | 42,749 | Jun 23, 2017, 04:09 PM |
| STAHL NEIL | EVP Research and Development | Jun 21, 2017 | Option Exercise | $30.63 | 20,000 | 612,600 | 43,950 | Jun 23, 2017, 04:09 PM |
| STAHL NEIL | EVP Research and Development | Jun 22, 2017 | Sale | $532.55 | 8,306 | 4,423,332 | 32,156 | Jun 23, 2017, 04:09 PM |
| GOLDSTEIN JOSEPH L | Director | Jun 20, 2017 | Option Exercise | $273.67 | 1,000 | 273,670 | 14,000 | Jun 21, 2017, 04:12 PM |
| GOLDSTEIN JOSEPH L | Director | Jun 20, 2017 | Sale | $500.01 | 1,000 | 500,010 | 13,000 | Jun 21, 2017, 04:12 PM |
| BROWN MICHAEL S | Director | Jun 20, 2017 | Option Exercise | $177.82 | 3,000 | 533,460 | 3,000 | Jun 21, 2017, 04:11 PM |
| BROWN MICHAEL S | Director | Jun 20, 2017 | Sale | $500.00 | 3,000 | 1,500,000 | 0 | Jun 21, 2017, 04:11 PM |
| Terifay Robert J | EVP Commercial | Jun 15, 2017 | Option Exercise | $468.69 | 27,603 | 12,937,250 | 66,632 | Jun 19, 2017, 04:44 PM |
| Terifay Robert J | EVP Commercial | Jun 15, 2017 | Option Exercise | $52.03 | 48,750 | 2,536,462 | 72,043 | Jun 19, 2017, 04:44 PM |
| Terifay Robert J | EVP Commercial | Jun 16, 2017 | Sale | $468.19 | 21,147 | 9,900,814 | 23,293 | Jun 19, 2017, 04:44 PM |
| STAHL NEIL | EVP Research and Development | Jun 14, 2017 | Option Exercise | $475.56 | 11,728 | 5,577,368 | 43,339 | Jun 16, 2017, 04:36 PM |
| STAHL NEIL | EVP Research and Development | Jun 14, 2017 | Option Exercise | $21.25 | 20,295 | 431,269 | 44,245 | Jun 16, 2017, 04:36 PM |
| STAHL NEIL | EVP Research and Development | Jun 15, 2017 | Sale | $468.45 | 8,567 | 4,013,177 | 32,017 | Jun 16, 2017, 04:36 PM |
| BROWN MICHAEL S | Director | Jun 12, 2017 | Option Exercise | $177.82 | 2,000 | 355,640 | 2,000 | Jun 14, 2017, 04:36 PM |
| BROWN MICHAEL S | Director | Jun 12, 2017 | Sale | $474.45 | 2,000 | 948,890 | 1,900 | Jun 14, 2017, 04:36 PM |
| GOLDSTEIN JOSEPH L | Director | Jun 09, 2017 | Option Exercise | $273.67 | 1,000 | 273,670 | 14,000 | Jun 13, 2017, 05:06 PM |
| GOLDSTEIN JOSEPH L | Director | Jun 09, 2017 | Sale | $482.55 | 1,000 | 482,550 | 13,000 | Jun 13, 2017, 05:06 PM |
| Sanofi | 10% Owner | Jun 02, 2017 | Buy | $478.17 | 136,050 | 65,055,548 | 23,641,744 | Jun 06, 2017, 05:00 PM |
| STAHL NEIL | EVP Research and Development | Jun 01, 2017 | Option Exercise | $464.98 | 7,732 | 3,595,225 | 28,929 | Jun 05, 2017, 04:52 PM |
| STAHL NEIL | EVP Research and Development | Jun 01, 2017 | Option Exercise | $198.38 | 10,544 | 2,091,724 | 30,814 | Jun 05, 2017, 04:52 PM |
| STAHL NEIL | EVP Research and Development | Jun 02, 2017 | Sale | $479.49 | 2,812 | 1,348,314 | 26,662 | Jun 05, 2017, 04:52 PM |
| VAGELOS P ROY | Chairman of the Board | May 25, 2017 | Sale | $458.14 | 9,295 | 4,258,373 | 89,437 | May 26, 2017, 04:04 PM |
| BROWN MICHAEL S | Director | May 12, 2017 | Option Exercise | $177.82 | 3,000 | 533,460 | 3,000 | May 15, 2017, 04:07 PM |
| BROWN MICHAEL S | Director | May 12, 2017 | Sale | $450.00 | 3,000 | 1,350,000 | 0 | May 15, 2017, 04:07 PM |
| BROWN MICHAEL S | Director | Mar 29, 2017 | Option Exercise | $177.82 | 1,000 | 177,820 | 1,000 | Mar 30, 2017, 04:42 PM |
| BROWN MICHAEL S | Director | Mar 29, 2017 | Sale | $400.00 | 1,000 | 400,000 | 0 | Mar 30, 2017, 04:42 PM |
| Sanofi | 10% Owner | Jan 11, 2017 | Buy | $369.71 | 87,298 | 32,274,865 | 23,505,694 | Jan 13, 2017, 04:15 PM |
| YANCOPOULOS GEORGE | President Regeneron Laboratori | Dec 15, 2016 | Option Exercise | $380.09 | 105,652 | 40,157,268 | 686,571 | Dec 19, 2016, 04:09 PM |
| YANCOPOULOS GEORGE | President Regeneron Laboratori | Dec 15, 2016 | Option Exercise | $20.32 | 195,079 | 3,964,005 | 697,000 | Dec 19, 2016, 04:09 PM |
| SCHLEIFER LEONARD S | President & CEO | Dec 15, 2016 | Option Exercise | $380.09 | 135,397 | 51,463,045 | 279,441 | Dec 19, 2016, 04:07 PM |
| SCHLEIFER LEONARD S | President & CEO | Dec 15, 2016 | Option Exercise | $20.32 | 250,000 | 5,080,000 | 292,806 | Dec 19, 2016, 04:07 PM |
| BAKER CHARLES A | Director | Dec 12, 2016 | Option Exercise | $18.61 | 3,000 | 55,830 | 12,000 | Dec 14, 2016, 05:41 PM |
| BAKER CHARLES A | Director | Dec 12, 2016 | Sale | $392.02 | 3,000 | 1,176,048 | 11,400 | Dec 14, 2016, 05:41 PM |
| RYAN ARTHUR F | Director | Nov 15, 2016 | Sale | $429.34 | 2,000 | 858,680 | 36,500 | Nov 16, 2016, 04:21 PM |
| GOLDSTEIN JOSEPH L | Director | Nov 14, 2016 | Option Exercise | $273.67 | 2,125 | 581,549 | 15,125 | Nov 15, 2016, 04:08 PM |
| GOLDSTEIN JOSEPH L | Director | Nov 14, 2016 | Sale | $450.00 | 2,125 | 956,250 | 13,000 | Nov 15, 2016, 04:08 PM |
| VAGELOS P ROY | Chairman of the Board | Nov 07, 2016 | Option Exercise | $355.52 | 41,782 | 14,854,336 | 511,332 | Nov 09, 2016, 04:10 PM |
| VAGELOS P ROY | Chairman of the Board | Nov 07, 2016 | Option Exercise | $20.32 | 76,895 | 1,562,506 | 515,726 | Nov 09, 2016, 04:10 PM |
| LAROSA JOSEPH J | SVP General Counsel and Secret | Sep 01, 2016 | Option Exercise | $392.63 | 4,943 | 1,940,770 | 11,813 | Sep 02, 2016, 04:02 PM |
| GOLDSTEIN JOSEPH L | Director | Jul 29, 2016 | Option Exercise | $273.67 | 2,125 | 581,549 | 15,125 | Aug 01, 2016, 04:04 PM |
| GOLDSTEIN JOSEPH L | Director | Jul 29, 2016 | Sale | $425.00 | 2,125 | 903,125 | 13,000 | Aug 01, 2016, 04:04 PM |
| Sanofi | 10% Owner | Jun 14, 2016 | Buy | $363.86 | 64,731 | 23,552,850 | 23,418,396 | Jun 16, 2016, 05:47 PM |
| RYAN ARTHUR F | Director | May 24, 2016 | Sale | $396.64 | 1,000 | 396,640 | 39,500 | May 25, 2016, 04:02 PM |
| Van Plew Daniel P | EVP & General Mgr Industrial O | May 17, 2016 | Option Exercise | $388.14 | 5,047 | 1,958,943 | 10,635 | May 19, 2016, 04:26 PM |
| Van Plew Daniel P | EVP & General Mgr Industrial O | May 17, 2016 | Option Exercise | $30.63 | 9,460 | 289,760 | 11,381 | May 19, 2016, 04:26 PM |
| Van Plew Daniel P | EVP & General Mgr Industrial O | May 18, 2016 | Sale | $385.77 | 4,413 | 1,702,403 | 1,921 | May 19, 2016, 04:26 PM |
| VAGELOS P ROY | Chairman of the Board | May 12, 2016 | Option Exercise | $368.70 | 124,733 | 45,989,059 | 550,851 | May 13, 2016, 04:40 PM |
| VAGELOS P ROY | Chairman of the Board | May 12, 2016 | Option Exercise | $20.32 | 230,684 | 4,687,499 | 563,564 | May 13, 2016, 04:40 PM |
| GOLDSTEIN JOSEPH L | Director | Apr 06, 2016 | Option Exercise | $177.82 | 1,000 | 177,820 | 14,000 | Apr 07, 2016, 04:19 PM |
| GOLDSTEIN JOSEPH L | Director | Apr 06, 2016 | Sale | $425.00 | 2,000 | 850,000 | 13,000 | Apr 07, 2016, 04:19 PM |
| GOLDSTEIN JOSEPH L | Director | Apr 01, 2016 | Option Exercise | $177.82 | 2,000 | 355,640 | 16,000 | Apr 04, 2016, 04:16 PM |
| GOLDSTEIN JOSEPH L | Director | Apr 01, 2016 | Sale | $400.00 | 2,000 | 800,000 | 14,000 | Apr 04, 2016, 04:16 PM |
| GOLDSTEIN JOSEPH L | Director | Mar 21, 2016 | Option Exercise | $177.82 | 2,000 | 355,640 | 16,000 | Mar 21, 2016, 04:27 PM |
| GOLDSTEIN JOSEPH L | Director | Mar 21, 2016 | Sale | $375.00 | 2,000 | 750,000 | 14,000 | Mar 21, 2016, 04:27 PM |
| Sanofi | 10% Owner | Feb 17, 2016 | Buy | $393.71 | 80,000 | 31,496,723 | 23,353,665 | Feb 18, 2016, 05:45 PM |
| Sanofi | 10% Owner | Feb 16, 2016 | Buy | $391.23 | 81,157 | 31,751,190 | 23,273,665 | Feb 18, 2016, 05:45 PM |
| Sanofi | 10% Owner | Jan 12, 2016 | Buy | $465.04 | 83,938 | 39,034,662 | 23,192,508 | Jan 14, 2016, 05:46 PM |
| McCorkle Douglas S | VP Controller and Asst Treasur | Dec 29, 2015 | Option Exercise | $52.03 | 3,954 | 205,727 | 10,820 | Dec 29, 2015, 07:44 PM |
| McCorkle Douglas S | VP Controller and Asst Treasur | Dec 29, 2015 | Sale | $552.08 | 3,954 | 2,182,924 | 6,866 | Dec 29, 2015, 07:44 PM |
| Aberman Michael S | SVP Strategy Investor Relation | Dec 17, 2015 | Option Exercise | $24.00 | 4,000 | 96,000 | 16,498 | Dec 18, 2015, 04:28 PM |
| McCorkle Douglas S | VP Controller and Asst Treasur | Dec 16, 2015 | Option Exercise | $52.03 | 1,921 | 99,950 | 6,866 | Dec 18, 2015, 04:28 PM |
| Powchik Peter | SVP Clinical Development & Reg | Dec 16, 2015 | Option Exercise | $52.03 | 1,921 | 99,950 | 17,742 | Dec 18, 2015, 04:27 PM |
| STAHL NEIL | EVP Research and Development | Dec 16, 2015 | Option Exercise | $52.03 | 1,921 | 99,950 | 27,594 | Dec 18, 2015, 04:27 PM |
| Van Plew Daniel P | SVP & General Mgr Industrial O | Dec 16, 2015 | Option Exercise | $52.03 | 1,921 | 99,950 | 1,921 | Dec 18, 2015, 04:27 PM |
| YANCOPOULOS GEORGE | President Regeneron Laboratori | Dec 16, 2015 | Option Exercise | $52.03 | 1,921 | 99,950 | 501,921 | Dec 18, 2015, 04:26 PM |
| BROWN MICHAEL S | Director | Dec 10, 2015 | Option Exercise | $177.82 | 3,000 | 533,460 | 3,000 | Dec 11, 2015, 04:14 PM |
| BROWN MICHAEL S | Director | Dec 10, 2015 | Sale | $546.45 | 3,000 | 1,639,365 | 2,900 | Dec 11, 2015, 04:14 PM |
| YANCOPOULOS GEORGE | President Regeneron Laboratori | Dec 02, 2015 | Sale | $549.03 | 43,348 | 23,799,539 | 542,250 | Dec 04, 2015, 04:13 PM |
| SING GEORGE L | Director | Nov 18, 2015 | Option Exercise | $19.69 | 3,000 | 59,070 | 115,772 | Nov 20, 2015, 04:04 PM |
| SING GEORGE L | Director | Nov 18, 2015 | Sale | $580.00 | 500 | 290,000 | 4,500 | Nov 20, 2015, 04:04 PM |
| SING GEORGE L | Director | Nov 18, 2015 | Sale | $580.00 | 3,000 | 1,740,000 | 112,772 | Nov 20, 2015, 04:04 PM |
| VAGELOS P ROY | Chairman of the Board | Nov 18, 2015 | Sale | $587.90 | 17,240 | 10,135,313 | 341,624 | Nov 19, 2015, 04:20 PM |
| Van Plew Daniel P | SVP & General Mgr Industrial O | Nov 06, 2015 | Option Exercise | $559.49 | 6,063 | 3,392,188 | 7,797 | Nov 10, 2015, 04:06 PM |
| Van Plew Daniel P | SVP & General Mgr Industrial O | Nov 06, 2015 | Option Exercise | $30.63 | 11,186 | 342,627 | 8,097 | Nov 10, 2015, 04:06 PM |
| Van Plew Daniel P | SVP & General Mgr Industrial O | Nov 10, 2015 | Sale | $554.85 | 5,123 | 2,842,520 | 4,273 | Nov 10, 2015, 04:06 PM |
| STAHL NEIL | EVP Research and Development | Nov 05, 2015 | Option Exercise | $567.63 | 57,899 | 32,865,210 | 92,982 | Nov 09, 2015, 05:10 PM |
| STAHL NEIL | EVP Research and Development | Nov 05, 2015 | Option Exercise | $28.28 | 100,000 | 2,828,500 | 97,029 | Nov 09, 2015, 05:10 PM |
| STAHL NEIL | EVP Research and Development | Nov 06, 2015 | Sale | $563.00 | 20,000 | 11,260,068 | 54,575 | Nov 09, 2015, 05:10 PM |
| STAHL NEIL | EVP Research and Development | Nov 09, 2015 | Sale | $560.05 | 22,101 | 12,377,559 | 34,436 | Nov 09, 2015, 05:10 PM |
| VAGELOS P ROY | Chairman of the Board | Nov 03, 2015 | Sale | $580.23 | 3,985 | 2,312,216 | 351,851 | Nov 04, 2015, 04:05 PM |
| VAGELOS P ROY | Chairman of the Board | Nov 02, 2015 | Sale | $580.18 | 13,257 | 7,691,446 | 355,836 | Nov 04, 2015, 04:05 PM |
| YANCOPOULOS GEORGE | President Regeneron Laboratori | Oct 30, 2015 | Option Exercise | $559.08 | 96,122 | 53,739,889 | 679,012 | Nov 03, 2015, 04:20 PM |
| YANCOPOULOS GEORGE | President Regeneron Laboratori | Oct 30, 2015 | Option Exercise | $11.64 | 182,818 | 2,128,002 | 682,818 | Nov 03, 2015, 04:20 PM |
| YANCOPOULOS GEORGE | President Regeneron Laboratori | Nov 02, 2015 | Sale | $571.61 | 43,348 | 24,778,124 | 585,496 | Nov 03, 2015, 04:20 PM |
| Sanofi | 10% Owner | Oct 06, 2015 | Buy | $472.33 | 11,040 | 5,214,519 | 23,108,570 | Oct 08, 2015, 05:50 PM |
| Sanofi | 10% Owner | Oct 06, 2015 | Buy | $459.71 | 80,538 | 37,024,185 | 23,097,530 | Oct 08, 2015, 05:45 PM |
| Sanofi | 10% Owner | Sep 23, 2015 | Buy | $534.67 | 147,209 | 78,708,573 | 23,016,992 | Sep 25, 2015, 05:45 PM |
| BROWN MICHAEL S | Director | Sep 21, 2015 | Option Exercise | $57.11 | 3,000 | 171,330 | 3,000 | Sep 22, 2015, 02:39 PM |
| BROWN MICHAEL S | Director | Sep 21, 2015 | Sale | $551.55 | 3,000 | 1,654,650 | 0 | Sep 22, 2015, 02:39 PM |
| BAKER CHARLES A | Director | Sep 17, 2015 | Option Exercise | $18.61 | 5,000 | 93,050 | 14,000 | Sep 18, 2015, 04:06 PM |
| BAKER CHARLES A | Director | Sep 17, 2015 | Sale | $550.00 | 5,000 | 2,750,000 | 9,000 | Sep 18, 2015, 04:06 PM |
| SCHLEIFER LEONARD S | President & CEO | Sep 02, 2015 | Option Exercise | $506.37 | 6,507 | 3,294,950 | 43,568 | Sep 03, 2015, 04:59 PM |
| SCHLEIFER LEONARD S | President & CEO | Sep 02, 2015 | Option Exercise | $402.69 | 7,226 | 2,909,838 | 49,313 | Sep 03, 2015, 04:59 PM |
| LAROSA JOSEPH J | SVP General Counsel and Secret | Sep 01, 2015 | Option Exercise | $59.20 | 1,689 | 99,989 | 16,756 | Sep 02, 2015, 04:04 PM |
| Powchik Peter | SVP Clinical Development & Reg | Aug 13, 2015 | Option Exercise | $579.35 | 36,876 | 21,364,110 | 44,234 | Aug 17, 2015, 04:01 PM |
| Powchik Peter | SVP Clinical Development & Reg | Aug 13, 2015 | Option Exercise | $117.33 | 60,361 | 7,082,070 | 46,299 | Aug 17, 2015, 04:01 PM |
| Powchik Peter | SVP Clinical Development & Reg | Aug 14, 2015 | Sale | $573.38 | 23,485 | 13,465,866 | 37,901 | Aug 17, 2015, 04:01 PM |
| POON CHRISTINE A | Director | Aug 11, 2015 | Option Exercise | $574.57 | 3,345 | 1,921,937 | 902 | Aug 12, 2015, 04:45 PM |
| POON CHRISTINE A | Director | Aug 11, 2015 | Option Exercise | $273.67 | 7,050 | 1,929,374 | 1,125 | Aug 12, 2015, 04:45 PM |
| POON CHRISTINE A | Director | Aug 12, 2015 | Sale | $564.16 | 1,680 | 947,791 | 802 | Aug 12, 2015, 04:45 PM |
| GILMAN ALFRED G | Director | Aug 06, 2015 | Option Exercise | $57.11 | 5,000 | 285,550 | 13,912 | Aug 07, 2015, 06:15 PM |
| GILMAN ALFRED G | Director | Aug 06, 2015 | Sale | $587.12 | 5,000 | 2,935,601 | 13,612 | Aug 07, 2015, 06:15 PM |
| Terifay Robert J | SVP Commercial | Aug 05, 2015 | Option Exercise | $588.64 | 15,813 | 9,308,165 | 51,008 | Aug 07, 2015, 06:14 PM |
| Terifay Robert J | SVP Commercial | Aug 05, 2015 | Option Exercise | $30.63 | 32,500 | 995,475 | 52,529 | Aug 07, 2015, 06:14 PM |
| Terifay Robert J | SVP Commercial | Aug 06, 2015 | Sale | $588.97 | 13,423 | 7,905,781 | 34,709 | Aug 07, 2015, 06:14 PM |
| Van Plew Daniel P | SVP & General Mgr Industrial O | Aug 05, 2015 | Option Exercise | $588.64 | 4,672 | 2,750,126 | 6,063 | Aug 07, 2015, 06:13 PM |
| Van Plew Daniel P | SVP & General Mgr Industrial O | Aug 05, 2015 | Option Exercise | $26.21 | 8,700 | 228,070 | 6,210 | Aug 07, 2015, 06:13 PM |
| Van Plew Daniel P | SVP & General Mgr Industrial O | Aug 06, 2015 | Sale | $584.36 | 4,028 | 2,353,807 | 3,028 | Aug 07, 2015, 06:13 PM |
| Landry Robert E | SVP Finance & CFO | Aug 05, 2015 | Option Exercise | $272.70 | 4,000 | 1,090,800 | 11,099 | Aug 06, 2015, 09:00 PM |
| Landry Robert E | SVP Finance & CFO | Aug 05, 2015 | Sale | $592.84 | 4,000 | 2,371,350 | 10,699 | Aug 06, 2015, 09:00 PM |
| McCorkle Douglas S | VP Controller and Asst Treasur | Aug 05, 2015 | Option Exercise | $270.43 | 5,000 | 1,352,150 | 9,745 | Aug 05, 2015, 08:58 PM |
| McCorkle Douglas S | VP Controller and Asst Treasur | Aug 05, 2015 | Sale | $585.53 | 5,000 | 2,927,648 | 4,945 | Aug 05, 2015, 08:58 PM |
| Tessier-Lavigne Marc | Director | Aug 05, 2015 | Option Exercise | $57.11 | 5,000 | 285,550 | 6,187 | Aug 05, 2015, 08:55 PM |
| Tessier-Lavigne Marc | Director | Aug 05, 2015 | Sale | $590.26 | 5,000 | 2,951,275 | 4,687 | Aug 05, 2015, 08:55 PM |
| GOLDSTEIN JOSEPH L | Director | Aug 04, 2015 | Sale | $586.00 | 2,000 | 1,172,000 | 14,000 | Aug 05, 2015, 10:03 AM |
| Sanofi | 10% Owner | Jul 27, 2015 | Buy | $537.48 | 10,639 | 5,718,271 | 22,869,783 | Jul 29, 2015, 05:46 PM |
| GOLDSTEIN JOSEPH L | Director | Jul 15, 2015 | Sale | $550.00 | 2,000 | 1,100,000 | 16,000 | Jul 15, 2015, 04:09 PM |
| GOLDSTEIN JOSEPH L | Director | Jun 22, 2015 | Sale | $526.85 | 2,000 | 1,053,700 | 18,000 | Jun 22, 2015, 05:02 PM |
| SING GEORGE L | Director | May 27, 2015 | Option Exercise | $19.69 | 5,000 | 98,450 | 117,772 | May 29, 2015, 04:19 PM |
| SING GEORGE L | Director | May 27, 2015 | Sale | $515.00 | 5,000 | 2,575,000 | 112,772 | May 29, 2015, 04:19 PM |
| INGRAM ROBERT ALEXANDER | Director | May 22, 2015 | Option Exercise | $516.48 | 3,788 | 1,956,426 | 2,879 | May 27, 2015, 04:02 PM |
| INGRAM ROBERT ALEXANDER | Director | May 22, 2015 | Option Exercise | $293.53 | 6,667 | 1,956,965 | 6,667 | May 27, 2015, 04:02 PM |
| INGRAM ROBERT ALEXANDER | Director | May 27, 2015 | Sale | $513.39 | 1,379 | 707,965 | 1,500 | May 27, 2015, 04:02 PM |
| Van Plew Daniel P | SVP & General Mgr Industrial O | May 22, 2015 | Option Exercise | $516.48 | 21,680 | 11,197,286 | 25,193 | May 26, 2015, 04:32 PM |
| Van Plew Daniel P | SVP & General Mgr Industrial O | May 22, 2015 | Option Exercise | $27.40 | 40,050 | 1,097,287 | 26,250 | May 26, 2015, 04:32 PM |
| Van Plew Daniel P | SVP & General Mgr Industrial O | May 26, 2015 | Sale | $508.42 | 18,370 | 9,339,737 | 11,491 | May 26, 2015, 04:32 PM |
| McCorkle Douglas S | VP Controller and Asst Treasur | May 22, 2015 | Option Exercise | $174.01 | 13,464 | 2,342,902 | 17,481 | May 26, 2015, 04:31 PM |
| McCorkle Douglas S | VP Controller and Asst Treasur | May 22, 2015 | Sale | $515.60 | 13,000 | 6,702,800 | 4,481 | May 26, 2015, 04:31 PM |
| GOLDSTEIN JOSEPH L | Director | May 22, 2015 | Sale | $514.27 | 4,000 | 2,057,100 | 22,000 | May 26, 2015, 04:30 PM |
| BROWN MICHAEL S | Director | May 15, 2015 | Option Exercise | $57.11 | 5,000 | 285,550 | 5,000 | May 18, 2015, 04:50 PM |
| BROWN MICHAEL S | Director | May 15, 2015 | Sale | $495.00 | 5,000 | 2,475,000 | 0 | May 18, 2015, 04:50 PM |
| Landry Robert E | SVP Finance & CFO | Apr 08, 2015 | Option Exercise | $449.50 | 7,901 | 3,551,500 | 8,934 | Apr 09, 2015, 04:03 PM |
| Landry Robert E | SVP Finance & CFO | Apr 08, 2015 | Option Exercise | $272.70 | 10,000 | 2,727,000 | 15,000 | Apr 09, 2015, 04:03 PM |
| LAROSA JOSEPH J | SVP General Counsel and Secret | Mar 25, 2015 | Option Exercise | $59.20 | 3,097 | 183,342 | 15,067 | Mar 26, 2015, 04:21 PM |
| BAKER CHARLES A | Director | Mar 25, 2015 | Option Exercise | $18.61 | 5,000 | 93,050 | 14,000 | Mar 26, 2015, 04:20 PM |
| BAKER CHARLES A | Director | Mar 25, 2015 | Sale | $454.96 | 5,000 | 2,274,785 | 13,700 | Mar 26, 2015, 04:20 PM |
| Aberman Michael S | SVP Strategy Investor Relation | Mar 23, 2015 | Option Exercise | $476.50 | 5,157 | 2,457,311 | 17,341 | Mar 25, 2015, 04:07 PM |
| Aberman Michael S | SVP Strategy Investor Relation | Mar 24, 2015 | Sale | $478.99 | 4,843 | 2,319,738 | 17,041 | Mar 25, 2015, 04:07 PM |
| Aberman Michael S | SVP Strategy Investor Relation | Mar 17, 2015 | Option Exercise | $457.91 | 4,058 | 1,858,199 | 29,605 | Mar 19, 2015, 04:05 PM |
| Aberman Michael S | SVP Strategy Investor Relation | Mar 17, 2015 | Option Exercise | $24.00 | 11,398 | 273,552 | 29,998 | Mar 19, 2015, 04:05 PM |
| Aberman Michael S | SVP Strategy Investor Relation | Mar 18, 2015 | Sale | $465.00 | 3,442 | 1,600,542 | 25,540 | Mar 19, 2015, 04:05 PM |
| Terifay Robert J | SVP Commercial | Mar 16, 2015 | Option Exercise | $444.46 | 13,382 | 5,947,764 | 42,725 | Mar 18, 2015, 06:03 PM |
| Terifay Robert J | SVP Commercial | Mar 16, 2015 | Option Exercise | $30.63 | 24,375 | 746,606 | 44,404 | Mar 18, 2015, 06:03 PM |
| Terifay Robert J | SVP Commercial | Mar 17, 2015 | Sale | $451.01 | 10,993 | 4,957,907 | 28,422 | Mar 18, 2015, 06:03 PM |
| LAROSA JOSEPH J | SVP General Counsel and Secret | Mar 16, 2015 | Option Exercise | $59.20 | 20,281 | 1,200,635 | 28,311 | Mar 17, 2015, 04:57 PM |
| LAROSA JOSEPH J | SVP General Counsel and Secret | Mar 16, 2015 | Sale | $450.00 | 18,311 | 8,239,950 | 10,000 | Mar 17, 2015, 04:57 PM |
| Tessier-Lavigne Marc | Director | Feb 26, 2015 | Option Exercise | $50.91 | 3,000 | 152,730 | 4,187 | Feb 27, 2015, 04:32 PM |
| Tessier-Lavigne Marc | Director | Feb 26, 2015 | Sale | $421.95 | 3,000 | 1,265,864 | 2,587 | Feb 27, 2015, 04:32 PM |
| McCorkle Douglas S | VP Controller and Asst Treasur | Feb 27, 2015 | Sale | $416.24 | 3,000 | 1,248,720 | 4,481 | Feb 27, 2015, 04:31 PM |
| Aberman Michael S | SVP Strategy Investor Relation | Feb 23, 2015 | Option Exercise | $427.94 | 4,126 | 1,765,680 | 25,564 | Feb 25, 2015, 04:02 PM |
| Aberman Michael S | SVP Strategy Investor Relation | Feb 23, 2015 | Option Exercise | $30.63 | 7,500 | 229,725 | 26,100 | Feb 25, 2015, 04:02 PM |
| Aberman Michael S | SVP Strategy Investor Relation | Feb 24, 2015 | Sale | $418.48 | 3,374 | 1,411,952 | 21,374 | Feb 25, 2015, 04:02 PM |
| Terifay Robert J | SVP Commercial | Feb 23, 2015 | Option Exercise | $427.94 | 13,202 | 5,649,664 | 42,660 | Feb 25, 2015, 04:01 PM |
| Terifay Robert J | SVP Commercial | Feb 23, 2015 | Option Exercise | $30.63 | 24,375 | 746,606 | 44,404 | Feb 25, 2015, 04:01 PM |
| Terifay Robert J | SVP Commercial | Feb 24, 2015 | Sale | $423.67 | 11,173 | 4,733,665 | 20,029 | Feb 25, 2015, 04:01 PM |
| SING GEORGE L | Director | Feb 20, 2015 | Option Exercise | $18.61 | 15,000 | 279,150 | 127,772 | Feb 24, 2015, 05:08 PM |
| SING GEORGE L | Director | Feb 20, 2015 | Sale | $423.12 | 15,000 | 6,346,800 | 112,772 | Feb 24, 2015, 05:08 PM |
| Van Plew Daniel P | SVP & General Mgr Industrial O | Feb 20, 2015 | Option Exercise | $424.70 | 10,569 | 4,488,654 | 37,705 | Feb 24, 2015, 05:08 PM |
| Van Plew Daniel P | SVP & General Mgr Industrial O | Feb 20, 2015 | Option Exercise | $21.25 | 20,000 | 425,000 | 38,705 | Feb 24, 2015, 05:08 PM |
| Van Plew Daniel P | SVP & General Mgr Industrial O | Feb 23, 2015 | Sale | $427.82 | 9,431 | 4,034,754 | 25,836 | Feb 24, 2015, 05:08 PM |
| BROWN MICHAEL S | Director | Feb 20, 2015 | Option Exercise | $57.11 | 1,000 | 57,110 | 1,000 | Feb 23, 2015, 04:07 PM |
| BROWN MICHAEL S | Director | Feb 20, 2015 | Sale | $422.72 | 1,000 | 422,720 | 0 | Feb 23, 2015, 04:07 PM |
| RYAN ARTHUR F | Director | Feb 20, 2015 | Option Exercise | $125.79 | 29,250 | 3,679,498 | 76,750 | Feb 23, 2015, 04:06 PM |
| RYAN ARTHUR F | Director | Feb 20, 2015 | Sale | $423.01 | 29,250 | 12,372,908 | 74,620 | Feb 23, 2015, 04:06 PM |
| GOLDSTEIN JOSEPH L | Director | Feb 20, 2015 | Option Exercise | $177.82 | 5,000 | 889,100 | 9,000 | Feb 20, 2015, 04:44 PM |
| GOLDSTEIN JOSEPH L | Director | Feb 20, 2015 | Sale | $423.65 | 5,000 | 2,118,262 | 8,600 | Feb 20, 2015, 04:44 PM |
| Aberman Michael S | SVP Strategy Investor Relation | Feb 13, 2015 | Option Exercise | $402.05 | 3,808 | 1,531,006 | 25,653 | Feb 18, 2015, 04:40 PM |
| Aberman Michael S | SVP Strategy Investor Relation | Feb 13, 2015 | Option Exercise | $24.00 | 7,500 | 180,000 | 26,100 | Feb 18, 2015, 04:40 PM |
| Aberman Michael S | SVP Strategy Investor Relation | Feb 17, 2015 | Sale | $404.46 | 3,692 | 1,493,266 | 22,192 | Feb 18, 2015, 04:40 PM |
| SCHLEIFER LEONARD S | President & CEO | Jan 02, 2015 | Sale | $410.58 | 1,500 | 615,867 | 1,103 | Jan 05, 2015, 04:56 PM |
| Powchik Peter | SVP Clinical Development & Reg | Dec 31, 2014 | Option Exercise | $412.78 | 14,178 | 5,852,395 | 32,560 | Jan 05, 2015, 04:28 PM |
| Powchik Peter | SVP Clinical Development & Reg | Dec 31, 2014 | Option Exercise | $52.03 | 25,000 | 1,300,750 | 35,711 | Jan 05, 2015, 04:28 PM |
| Powchik Peter | SVP Clinical Development & Reg | Jan 02, 2015 | Sale | $414.08 | 10,822 | 4,481,214 | 20,133 | Jan 05, 2015, 04:28 PM |
| Sanofi | 10% Owner | Dec 24, 2014 | Buy | $398.79 | 30,002 | 11,964,489 | 22,859,144 | Dec 29, 2014, 05:40 PM |
| Sanofi | 10% Owner | Dec 23, 2014 | Buy | $392.23 | 171,457 | 67,251,122 | 22,829,142 | Dec 29, 2014, 05:40 PM |
| Powchik Peter | SVP Clinical Development & Reg | Dec 19, 2014 | Option Exercise | $30.63 | 3,264 | 99,976 | 10,711 | Dec 22, 2014, 12:09 PM |
| Van Plew Daniel P | SVP & General Mgr Industrial O | Dec 18, 2014 | Option Exercise | $30.63 | 3,264 | 99,976 | 18,705 | Dec 19, 2014, 02:11 PM |
| STAHL NEIL | SVP Research and Development S | Dec 16, 2014 | Option Exercise | $30.63 | 3,264 | 99,976 | 6,541 | Dec 18, 2014, 04:25 PM |
| GOLDBERG MURRAY A | SVP Administration & Asst Secr | Dec 16, 2014 | Option Exercise | $30.63 | 3,264 | 99,976 | 64,436 | Dec 18, 2014, 04:25 PM |
| YANCOPOULOS GEORGE | President Regeneron Laboratori | Dec 16, 2014 | Option Exercise | $30.63 | 3,264 | 99,976 | 503,264 | Dec 18, 2014, 04:23 PM |
| McCorkle Douglas S | VP Controller and Asst Treasur | Dec 17, 2014 | Option Exercise | $30.63 | 2,800 | 85,764 | 7,481 | Dec 18, 2014, 04:22 PM |
| McCorkle Douglas S | VP Controller and Asst Treasur | Dec 15, 2014 | Option Exercise | $30.63 | 1,668 | 51,091 | 6,049 | Dec 17, 2014, 04:51 PM |
| McCorkle Douglas S | VP Controller and Asst Treasur | Dec 16, 2014 | Option Exercise | $49.07 | 6,818 | 334,560 | 10,556 | Dec 17, 2014, 04:51 PM |
| McCorkle Douglas S | VP Controller and Asst Treasur | Dec 16, 2014 | Sale | $410.00 | 6,818 | 2,795,380 | 4,681 | Dec 17, 2014, 04:51 PM |
| McCorkle Douglas S | VP Controller and Asst Treasur | Dec 15, 2014 | Sale | $410.76 | 1,668 | 685,144 | 4,681 | Dec 17, 2014, 04:51 PM |
| POON CHRISTINE A | Director | Nov 25, 2014 | Buy | $410.00 | 400 | 164,000 | 655 | Nov 26, 2014, 01:28 PM |
| GILMAN ALFRED G | Director | Nov 24, 2014 | Option Exercise | $35.96 | 40,000 | 1,438,550 | 40,000 | Nov 25, 2014, 04:16 PM |
| GILMAN ALFRED G | Director | Nov 24, 2014 | Sale | $408.44 | 40,000 | 16,337,584 | 35,400 | Nov 25, 2014, 04:16 PM |
| STAHL NEIL | SVP Research and Development S | Nov 24, 2014 | Sale | $409.78 | 2,200 | 901,523 | 3,690 | Nov 24, 2014, 04:15 PM |
| STAHL NEIL | SVP Research and Development S | Nov 21, 2014 | Sale | $415.16 | 3,107 | 1,289,902 | 5,477 | Nov 24, 2014, 04:15 PM |
| STAHL NEIL | SVP Research and Development S | Nov 18, 2014 | Option Exercise | $406.93 | 11,450 | 4,659,348 | 25,537 | Nov 20, 2014, 04:14 PM |
| STAHL NEIL | SVP Research and Development S | Nov 18, 2014 | Option Exercise | $115.29 | 16,757 | 1,931,915 | 30,284 | Nov 20, 2014, 04:14 PM |
| Terifay Robert J | SVP Commercial | Nov 17, 2014 | Option Exercise | $401.75 | 26,388 | 10,601,379 | 66,201 | Nov 19, 2014, 04:41 PM |
| Terifay Robert J | SVP Commercial | Nov 17, 2014 | Option Exercise | $21.25 | 48,750 | 1,035,938 | 68,779 | Nov 19, 2014, 04:41 PM |
| Terifay Robert J | SVP Commercial | Nov 18, 2014 | Sale | $405.79 | 22,362 | 9,074,200 | 42,329 | Nov 19, 2014, 04:41 PM |
| Van Plew Daniel P | SVP & General Mgr Industrial O | Nov 12, 2014 | Option Exercise | $398.93 | 10,125 | 4,039,166 | 33,145 | Nov 14, 2014, 04:32 PM |
| Van Plew Daniel P | SVP & General Mgr Industrial O | Nov 12, 2014 | Option Exercise | $21.25 | 18,700 | 397,375 | 34,141 | Nov 14, 2014, 04:32 PM |
| Van Plew Daniel P | SVP & General Mgr Industrial O | Nov 13, 2014 | Sale | $399.34 | 8,575 | 3,424,336 | 16,942 | Nov 14, 2014, 04:32 PM |
| GOLDSTEIN JOSEPH L | Director | Nov 12, 2014 | Option Exercise | $177.82 | 5,000 | 889,100 | 9,000 | Nov 12, 2014, 05:15 PM |
| GOLDSTEIN JOSEPH L | Director | Nov 12, 2014 | Sale | $398.31 | 5,000 | 1,991,550 | 4,000 | Nov 12, 2014, 05:15 PM |
| SCHLEIFER LEONARD S | President & CEO | Nov 12, 2014 | Sale | $400.32 | 42,324 | 16,943,285 | 46,947 | Nov 12, 2014, 05:14 PM |
| SCHLEIFER LEONARD S | President & CEO | Nov 11, 2014 | Sale | $400.00 | 3,493 | 1,397,200 | 84,411 | Nov 12, 2014, 05:14 PM |
| SCHLEIFER LEONARD S | President & CEO | Oct 31, 2014 | Sale | $400.11 | 3,453 | 1,381,580 | 87,904 | Nov 04, 2014, 04:06 PM |
| SCHLEIFER LEONARD S | President & CEO | Oct 27, 2014 | Option Exercise | $402.69 | 138,426 | 55,742,766 | 285,667 | Oct 29, 2014, 04:27 PM |
| SCHLEIFER LEONARD S | President & CEO | Oct 27, 2014 | Option Exercise | $19.40 | 256,808 | 4,982,219 | 292,893 | Oct 29, 2014, 04:27 PM |
| SCHLEIFER LEONARD S | President & CEO | Oct 28, 2014 | Sale | $404.01 | 69,112 | 27,921,806 | 148,147 | Oct 29, 2014, 04:27 PM |
| GOLDBERG MURRAY A | SVP Administration & Asst Secr | Oct 23, 2014 | Option Exercise | $391.93 | 33,212 | 13,016,779 | 118,413 | Oct 27, 2014, 04:17 PM |
| GOLDBERG MURRAY A | SVP Administration & Asst Secr | Oct 23, 2014 | Option Exercise | $30.63 | 60,000 | 1,837,800 | 123,102 | Oct 27, 2014, 04:17 PM |
| GOLDBERG MURRAY A | SVP Administration & Asst Secr | Oct 24, 2014 | Sale | $400.70 | 26,788 | 10,734,018 | 89,690 | Oct 27, 2014, 04:17 PM |
| BROWN MICHAEL S | Director | Oct 24, 2014 | Option Exercise | $57.11 | 5,000 | 285,550 | 5,000 | Oct 24, 2014, 04:07 PM |
| BROWN MICHAEL S | Director | Oct 24, 2014 | Sale | $399.00 | 5,000 | 1,995,000 | 0 | Oct 24, 2014, 04:07 PM |
| Sanofi | 10% Owner | Oct 16, 2014 | Buy | $335.35 | 122,127 | 40,955,051 | 22,657,685 | Oct 20, 2014, 05:45 PM |
| Sanofi | 10% Owner | Oct 15, 2014 | Buy | $328.16 | 158,368 | 51,970,275 | 22,535,558 | Oct 17, 2014, 05:05 PM |
| Sanofi | 10% Owner | Sep 16, 2014 | Buy | $349.26 | 31,717 | 11,077,580 | 22,377,190 | Sep 18, 2014, 05:45 PM |
| Sanofi | 10% Owner | Sep 15, 2014 | Buy | $343.98 | 80,824 | 27,802,191 | 22,345,473 | Sep 16, 2014, 05:45 PM |
| Sanofi | 10% Owner | Sep 12, 2014 | Buy | $346.74 | 59,808 | 20,737,539 | 22,264,649 | Sep 16, 2014, 05:45 PM |
| VAGELOS P ROY | Chairman of the Board | Sep 10, 2014 | Sale | $350.07 | 10,326 | 3,614,823 | 92,947 | Sep 10, 2014, 04:00 PM |
| VAGELOS P ROY | Chairman of the Board | Sep 08, 2014 | Sale | $351.00 | 2 | 702 | 103,273 | Sep 10, 2014, 04:00 PM |
| YANCOPOULOS GEORGE | President Regeneron Laboratori | Aug 27, 2014 | Option Exercise | $351.33 | 5,426 | 1,906,317 | 500,604 | Aug 29, 2014, 03:29 PM |
| YANCOPOULOS GEORGE | President Regeneron Laboratori | Aug 27, 2014 | Option Exercise | $314.31 | 5,720 | 1,797,853 | 505,720 | Aug 29, 2014, 03:29 PM |
| McCorkle Douglas S | VP Controller and Asst Treasur | Aug 27, 2014 | Option Exercise | $21.56 | 1,681 | 36,247 | 4,681 | Aug 28, 2014, 02:39 PM |
| VAGELOS P ROY | Chairman of the Board | Aug 26, 2014 | Option Exercise | $351.62 | 161,597 | 56,820,736 | 542,389 | Aug 27, 2014, 05:03 PM |
| VAGELOS P ROY | Chairman of the Board | Aug 26, 2014 | Option Exercise | $11.64 | 303,909 | 3,537,501 | 552,449 | Aug 27, 2014, 05:03 PM |
| Tessier-Lavigne Marc | Director | Aug 26, 2014 | Option Exercise | $351.62 | 200 | 70,324 | 1,187 | Aug 27, 2014, 05:02 PM |
| Tessier-Lavigne Marc | Director | Aug 27, 2014 | Option Exercise | $50.91 | 3,000 | 152,730 | 4,187 | Aug 27, 2014, 05:02 PM |
| Tessier-Lavigne Marc | Director | Aug 26, 2014 | Option Exercise | $50.91 | 1,387 | 70,612 | 1,387 | Aug 27, 2014, 05:02 PM |
| Tessier-Lavigne Marc | Director | Aug 27, 2014 | Sale | $352.20 | 3,000 | 1,056,600 | 1,187 | Aug 27, 2014, 05:02 PM |
| GOLDSTEIN JOSEPH L | Director | Aug 27, 2014 | Sale | $350.31 | 2,000 | 700,620 | 4,000 | Aug 27, 2014, 05:01 PM |
| Aberman Michael S | VP Strategy and Investor Relat | Aug 22, 2014 | Option Exercise | $24.00 | 3,000 | 72,000 | 18,600 | Aug 26, 2014, 09:45 AM |
| Aberman Michael S | VP Strategy and Investor Relat | Aug 18, 2014 | Option Exercise | $351.06 | 5,139 | 1,804,097 | 23,054 | Aug 19, 2014, 04:16 PM |
| Aberman Michael S | VP Strategy and Investor Relat | Aug 18, 2014 | Option Exercise | $52.03 | 8,750 | 455,262 | 24,350 | Aug 19, 2014, 04:16 PM |
| Aberman Michael S | VP Strategy and Investor Relat | Aug 19, 2014 | Sale | $350.00 | 3,611 | 1,263,850 | 15,600 | Aug 19, 2014, 04:16 PM |
| McCorkle Douglas S | VP Controller and Asst Treasur | Aug 18, 2014 | Option Exercise | $52.03 | 5,875 | 305,676 | 8,875 | Aug 18, 2014, 04:04 PM |
| McCorkle Douglas S | VP Controller and Asst Treasur | Aug 18, 2014 | Sale | $353.00 | 5,875 | 2,073,875 | 3,000 | Aug 18, 2014, 04:04 PM |
| BROWN MICHAEL S | Director | Aug 15, 2014 | Option Exercise | $33.42 | 3,000 | 100,260 | 3,000 | Aug 18, 2014, 04:02 PM |
| BROWN MICHAEL S | Director | Aug 15, 2014 | Sale | $349.20 | 3,000 | 1,047,600 | 0 | Aug 18, 2014, 04:02 PM |
| VAGELOS P ROY | Chairman of the Board | Aug 13, 2014 | Sale | $340.01 | 8,028 | 2,729,600 | 248,540 | Aug 14, 2014, 04:15 PM |
| GOLDSTEIN JOSEPH L | Director | Aug 14, 2014 | Sale | $347.65 | 2,000 | 695,300 | 6,000 | Aug 14, 2014, 04:14 PM |
| VAGELOS P ROY | Chairman of the Board | Aug 07, 2014 | Option Exercise | $340.12 | 142,651 | 48,518,457 | 403,648 | Aug 11, 2014, 05:25 PM |
| VAGELOS P ROY | Chairman of the Board | Aug 07, 2014 | Option Exercise | $9.49 | 270,352 | 2,565,640 | 411,191 | Aug 11, 2014, 05:25 PM |
| VAGELOS P ROY | Chairman of the Board | Aug 11, 2014 | Sale | $340.05 | 9,372 | 3,186,967 | 256,868 | Aug 11, 2014, 05:25 PM |
| VAGELOS P ROY | Chairman of the Board | Aug 08, 2014 | Sale | $340.33 | 2,600 | 884,858 | 265,940 | Aug 11, 2014, 05:25 PM |
| STAHL NEIL | SVP Research and Development S | Aug 11, 2014 | Sale | $339.96 | 11,646 | 3,959,204 | 23,556 | Aug 11, 2014, 04:04 PM |
| STAHL NEIL | SVP Research and Development S | Aug 06, 2014 | Option Exercise | $336.11 | 20,513 | 6,894,624 | 46,315 | Aug 08, 2014, 04:49 PM |
| STAHL NEIL | SVP Research and Development S | Aug 06, 2014 | Option Exercise | $21.25 | 35,000 | 743,750 | 48,527 | Aug 08, 2014, 04:49 PM |
| STAHL NEIL | SVP Research and Development S | Aug 08, 2014 | Sale | $340.64 | 2,100 | 715,340 | 25,373 | Aug 08, 2014, 04:49 PM |
| STAHL NEIL | SVP Research and Development S | Aug 07, 2014 | Sale | $340.49 | 741 | 252,304 | 27,390 | Aug 08, 2014, 04:49 PM |
| Van Plew Daniel P | SVP & General Mgr Industrial O | Aug 06, 2014 | Option Exercise | $336.11 | 8,194 | 2,754,085 | 29,493 | Aug 07, 2014, 04:35 PM |
| Van Plew Daniel P | SVP & General Mgr Industrial O | Aug 06, 2014 | Option Exercise | $21.25 | 15,000 | 318,750 | 30,441 | Aug 07, 2014, 04:35 PM |
| Van Plew Daniel P | SVP & General Mgr Industrial O | Aug 07, 2014 | Sale | $338.37 | 6,806 | 2,302,946 | 15,441 | Aug 07, 2014, 04:35 PM |
| GOLDSTEIN JOSEPH L | Director | Aug 06, 2014 | Sale | $331.20 | 2,000 | 662,400 | 8,000 | Aug 06, 2014, 04:11 PM |
| Sanofi | 10% Owner | Jul 15, 2014 | Buy | $314.92 | 129,100 | 40,656,162 | 22,204,841 | Jul 17, 2014, 05:50 PM |
| Sanofi | 10% Owner | Jul 14, 2014 | Buy | $318.18 | 150,000 | 47,726,811 | 22,075,741 | Jul 15, 2014, 05:45 PM |
| Sanofi | 10% Owner | Jul 11, 2014 | Buy | $315.41 | 150,000 | 47,311,806 | 21,925,741 | Jul 15, 2014, 05:45 PM |
| Sanofi | 10% Owner | Jul 10, 2014 | Buy | $311.08 | 175,000 | 54,439,075 | 21,775,741 | Jul 14, 2014, 05:46 PM |
| Sanofi | 10% Owner | Jul 09, 2014 | Buy | $308.27 | 195,000 | 60,112,337 | 21,600,741 | Jul 10, 2014, 05:45 PM |
| Sanofi | 10% Owner | Jul 08, 2014 | Buy | $311.67 | 153,000 | 47,685,740 | 21,405,741 | Jul 10, 2014, 05:45 PM |
| Sanofi | 10% Owner | Jul 07, 2014 | Buy | $312.90 | 256,700 | 80,320,839 | 21,252,741 | Jul 08, 2014, 05:42 PM |
| Sanofi | 10% Owner | Jul 03, 2014 | Buy | $311.02 | 100,000 | 31,101,948 | 20,996,041 | Jul 08, 2014, 05:42 PM |
| Sanofi | 10% Owner | Jul 02, 2014 | Buy | $307.25 | 212,400 | 65,259,554 | 20,896,041 | Jul 03, 2014, 06:00 PM |
| Sanofi | 10% Owner | Jul 01, 2014 | Buy | $300.19 | 212,400 | 63,761,391 | 20,683,641 | Jul 03, 2014, 05:46 PM |
| Sanofi | 10% Owner | Jun 30, 2014 | Buy | $282.54 | 212,400 | 60,010,495 | 20,471,241 | Jul 01, 2014, 05:39 PM |
| Sanofi | 10% Owner | Jun 27, 2014 | Buy | $275.38 | 50,000 | 13,769,092 | 20,258,841 | Jul 01, 2014, 05:39 PM |
| Van Plew Daniel P | SVP & General Mgr Industrial O | May 22, 2014 | Option Exercise | $296.19 | 5,831 | 1,727,084 | 25,838 | May 23, 2014, 03:58 PM |
| Van Plew Daniel P | SVP & General Mgr Industrial O | May 22, 2014 | Option Exercise | $21.25 | 11,200 | 238,000 | 26,641 | May 23, 2014, 03:58 PM |
| Van Plew Daniel P | SVP & General Mgr Industrial O | May 23, 2014 | Sale | $295.93 | 5,369 | 1,588,872 | 17,810 | May 23, 2014, 03:58 PM |
| POON CHRISTINE A | Director | May 21, 2014 | Buy | $291.90 | 255 | 74,434 | 255 | May 23, 2014, 10:43 AM |
| Sanofi | 10% Owner | May 19, 2014 | Buy | $300.04 | 190,751 | 57,233,716 | 20,208,841 | May 21, 2014, 05:02 PM |
| Sanofi | 10% Owner | Mar 28, 2014 | Buy | $306.73 | 306,945 | 94,149,580 | 20,018,090 | Mar 31, 2014, 06:22 PM |
| Sanofi | 10% Owner | Mar 27, 2014 | Buy | $311.01 | 306,945 | 95,463,977 | 19,711,145 | Mar 31, 2014, 06:21 PM |
| BAKER CHARLES A | Director | Mar 24, 2014 | Option Exercise | $23.84 | 15,000 | 357,600 | 24,000 | Mar 25, 2014, 08:03 PM |
| BAKER CHARLES A | Director | Mar 24, 2014 | Sale | $302.67 | 15,000 | 4,540,001 | 13,800 | Mar 25, 2014, 08:03 PM |
| Sanofi | 10% Owner | Mar 24, 2014 | Buy | $307.91 | 306,945 | 94,511,731 | 18,790,310 | Mar 25, 2014, 06:11 PM |
| Sanofi | 10% Owner | Mar 21, 2014 | Buy | $321.22 | 305,115 | 98,008,225 | 18,483,365 | Mar 25, 2014, 06:10 PM |
| Sanofi | 10% Owner | Mar 20, 2014 | Buy | $328.41 | 57,957 | 19,033,495 | 18,178,250 | Mar 21, 2014, 06:21 PM |
| Sanofi | 10% Owner | Mar 19, 2014 | Buy | $327.89 | 9,746 | 3,195,655 | 18,120,293 | Mar 21, 2014, 06:21 PM |
| Sanofi | 10% Owner | Mar 17, 2014 | Buy | $328.55 | 60,128 | 19,755,210 | 18,110,547 | Mar 18, 2014, 06:58 PM |
| Sanofi | 10% Owner | Mar 14, 2014 | Buy | $328.36 | 55,583 | 18,251,213 | 18,050,419 | Mar 18, 2014, 06:58 PM |
| BROWN MICHAEL S | Director | Mar 17, 2014 | Option Exercise | $33.42 | 2,000 | 66,840 | 16,662 | Mar 18, 2014, 05:09 PM |
| BROWN MICHAEL S | Director | Mar 17, 2014 | Sale | $334.29 | 2,000 | 668,573 | 15,562 | Mar 18, 2014, 05:09 PM |
| Sanofi | 10% Owner | Mar 12, 2014 | Buy | $334.69 | 220,995 | 73,964,382 | 17,994,836 | Mar 14, 2014, 05:11 PM |
| Sanofi | 10% Owner | Mar 11, 2014 | Buy | $332.26 | 180,710 | 60,043,318 | 17,773,841 | Mar 12, 2014, 05:36 PM |
| Sanofi | 10% Owner | Mar 10, 2014 | Buy | $328.73 | 199,822 | 65,687,441 | 17,593,131 | Mar 12, 2014, 05:36 PM |
| Sanofi | 10% Owner | Mar 07, 2014 | Buy | $332.51 | 241,818 | 80,405,802 | 17,393,309 | Mar 10, 2014, 09:52 PM |
| Sanofi | 10% Owner | Mar 07, 2014 | Buy | $316.20 | 69,873 | 22,093,659 | 17,151,491 | Mar 10, 2014, 09:51 PM |
| Sanofi | 10% Owner | Mar 06, 2014 | Buy | $339.60 | 80,404 | 27,305,559 | 17,081,618 | Mar 10, 2014, 09:51 PM |
| Sanofi | 10% Owner | Mar 03, 2014 | Buy | $338.12 | 251,594 | 85,070,060 | 17,001,214 | Mar 05, 2014, 08:36 PM |
| VAGELOS P ROY | Chairman of the Board | Feb 27, 2014 | Option Exercise | $12.70 | 70,879 | 899,952 | 140,839 | Mar 03, 2014, 09:10 AM |
| BROWN MICHAEL S | Director | Feb 26, 2014 | Option Exercise | $57.11 | 1,000 | 57,110 | 15,662 | Feb 27, 2014, 04:30 PM |
| BROWN MICHAEL S | Director | Feb 27, 2014 | Sale | $335.00 | 1,000 | 335,000 | 14,662 | Feb 27, 2014, 04:30 PM |
| GOLDBERG MURRAY A | SVP Administration & Asst Secr | Feb 24, 2014 | Option Exercise | $342.63 | 18,356 | 6,289,316 | 82,329 | Feb 26, 2014, 04:57 PM |
| GOLDBERG MURRAY A | SVP Administration & Asst Secr | Feb 24, 2014 | Option Exercise | $64.90 | 30,227 | 1,961,746 | 85,365 | Feb 26, 2014, 04:57 PM |
| GOLDBERG MURRAY A | SVP Administration & Asst Secr | Feb 25, 2014 | Sale | $339.55 | 11,871 | 4,030,823 | 74,698 | Feb 26, 2014, 04:57 PM |
| GOLDSTEIN JOSEPH L | Director | Feb 25, 2014 | Sale | $338.86 | 1,000 | 338,860 | 0 | Feb 25, 2014, 05:48 PM |
| SING GEORGE L | Director | Feb 21, 2014 | Option Exercise | $15.80 | 15,000 | 237,000 | 117,772 | Feb 24, 2014, 04:12 PM |
| SING GEORGE L | Director | Feb 21, 2014 | Sale | $339.00 | 15,000 | 5,085,000 | 112,772 | Feb 24, 2014, 04:12 PM |
| GILMAN ALFRED G | Director | Feb 21, 2014 | Option Exercise | $18.61 | 5,000 | 93,050 | 5,000 | Feb 24, 2014, 04:12 PM |
| GILMAN ALFRED G | Director | Feb 21, 2014 | Sale | $340.00 | 5,000 | 1,700,000 | 0 | Feb 24, 2014, 04:12 PM |
| GOLDBERG MURRAY A | SVP Administration & Asst Secr | Feb 20, 2014 | Option Exercise | $326.05 | 29,394 | 9,583,913 | 90,284 | Feb 24, 2014, 04:11 PM |
| GOLDBERG MURRAY A | SVP Administration & Asst Secr | Feb 20, 2014 | Option Exercise | $47.79 | 50,652 | 2,420,804 | 93,102 | Feb 24, 2014, 04:11 PM |
| GOLDBERG MURRAY A | SVP Administration & Asst Secr | Feb 21, 2014 | Sale | $336.51 | 21,258 | 7,153,608 | 83,960 | Feb 24, 2014, 04:11 PM |
| GOLDSTEIN JOSEPH L | Director | Feb 20, 2014 | Sale | $326.99 | 1,000 | 326,988 | 1,950 | Feb 21, 2014, 04:44 PM |
| McCorkle Douglas S | VP Controller and Asst Treasur | Feb 20, 2014 | Option Exercise | $21.25 | 3,000 | 63,750 | 3,000 | Feb 21, 2014, 04:43 PM |
| Aberman Michael S | VP Strategy and Investor Relat | Feb 14, 2014 | Option Exercise | $323.30 | 3,852 | 1,245,352 | 22,390 | Feb 19, 2014, 04:12 PM |
| Aberman Michael S | VP Strategy and Investor Relat | Feb 14, 2014 | Option Exercise | $30.63 | 7,500 | 229,725 | 23,100 | Feb 19, 2014, 04:12 PM |
| Aberman Michael S | VP Strategy and Investor Relat | Feb 18, 2014 | Sale | $331.42 | 3,648 | 1,209,036 | 19,148 | Feb 19, 2014, 04:12 PM |
| SING GEORGE L | Director | Feb 14, 2014 | Option Exercise | $9.17 | 15,000 | 137,550 | 127,772 | Feb 19, 2014, 04:11 PM |
| SING GEORGE L | Director | Feb 14, 2014 | Sale | $324.00 | 15,000 | 4,860,000 | 112,772 | Feb 19, 2014, 04:11 PM |
| Terifay Robert J | SVP Commercial | Feb 14, 2014 | Option Exercise | $323.30 | 14,930 | 4,826,869 | 45,998 | Feb 19, 2014, 04:10 PM |
| Terifay Robert J | SVP Commercial | Feb 14, 2014 | Option Exercise | $21.25 | 27,795 | 590,644 | 47,824 | Feb 19, 2014, 04:10 PM |
| Terifay Robert J | SVP Commercial | Feb 18, 2014 | Sale | $332.68 | 12,865 | 4,279,893 | 29,397 | Feb 19, 2014, 04:10 PM |
| SHOOTER ERIC M | Director | Feb 12, 2014 | Option Exercise | $89.45 | 15,000 | 1,341,750 | 15,000 | Feb 13, 2014, 07:38 PM |
| SHOOTER ERIC M | Director | Feb 12, 2014 | Sale | $320.52 | 15,000 | 4,807,869 | 2,122 | Feb 13, 2014, 07:38 PM |
| STAHL NEIL | SVP Research and Development S | Feb 12, 2014 | Option Exercise | $324.44 | 31,936 | 10,361,316 | 61,772 | Feb 13, 2014, 06:32 PM |
| STAHL NEIL | SVP Research and Development S | Feb 12, 2014 | Option Exercise | $20.06 | 54,548 | 1,094,406 | 64,391 | Feb 13, 2014, 06:32 PM |
| STAHL NEIL | SVP Research and Development S | Feb 13, 2014 | Sale | $318.82 | 22,612 | 7,209,136 | 45,203 | Feb 13, 2014, 06:32 PM |
| GOLDSTEIN JOSEPH L | Director | Feb 12, 2014 | Sale | $320.62 | 1,000 | 320,620 | 2,000 | Feb 13, 2014, 04:06 PM |
| YANCOPOULOS GEORGE | President Regeneron Laboratori | Feb 11, 2014 | Option Exercise | $314.31 | 100,476 | 31,580,611 | 1,252,086 | Feb 13, 2014, 04:03 PM |
| YANCOPOULOS GEORGE | President Regeneron Laboratori | Feb 11, 2014 | Option Exercise | $9.49 | 189,463 | 1,798,004 | 1,257,806 | Feb 13, 2014, 04:03 PM |
| YANCOPOULOS GEORGE | President Regeneron Laboratori | Feb 12, 2014 | Sale | $320.33 | 88,987 | 28,504,985 | 1,153,008 | Feb 13, 2014, 04:03 PM |
| GILMAN ALFRED G | Director | Feb 11, 2014 | Option Exercise | $18.61 | 5,000 | 93,050 | 5,000 | Feb 12, 2014, 04:17 PM |
| GILMAN ALFRED G | Director | Feb 11, 2014 | Sale | $320.00 | 5,000 | 1,600,000 | 0 | Feb 12, 2014, 04:17 PM |
| McCorkle Douglas S | VP Controller and Asst Treasur | Feb 11, 2014 | Option Exercise | $30.63 | 5,819 | 178,236 | 5,819 | Feb 12, 2014, 04:15 PM |
| McCorkle Douglas S | VP Controller and Asst Treasur | Feb 11, 2014 | Sale | $325.00 | 5,819 | 1,891,175 | 0 | Feb 12, 2014, 04:15 PM |
| VAGELOS P ROY | Chairman of the Board | Feb 11, 2014 | Sale | $325.10 | 11,475 | 3,730,523 | 103,275 | Feb 12, 2014, 04:15 PM |
| Sanofi | 10% Owner | Feb 07, 2014 | Buy | $287.34 | 21,986 | 6,317,456 | 16,749,620 | Feb 10, 2014, 06:46 PM |
| Sanofi | 10% Owner | Feb 06, 2014 | Buy | $286.70 | 146,525 | 42,008,334 | 16,727,634 | Feb 10, 2014, 06:46 PM |
| Sanofi | 10% Owner | Feb 04, 2014 | Buy | $286.44 | 190,286 | 54,504,787 | 16,374,131 | Feb 06, 2014, 07:30 PM |
| Sanofi | 10% Owner | Feb 05, 2014 | Buy | $282.00 | 206,978 | 58,367,122 | 16,581,109 | Feb 06, 2014, 07:30 PM |
| Sanofi | 10% Owner | Feb 03, 2014 | Buy | $283.46 | 198,058 | 56,141,721 | 16,183,845 | Feb 04, 2014, 07:11 PM |
| Sanofi | 10% Owner | Jan 31, 2014 | Buy | $289.66 | 10,914 | 3,161,381 | 15,985,787 | Feb 04, 2014, 07:11 PM |
| Sanofi | 10% Owner | Jan 28, 2014 | Buy | $278.54 | 83,235 | 23,184,314 | 15,974,873 | Jan 29, 2014, 08:20 AM |
| Sanofi | 10% Owner | Jan 27, 2014 | Buy | $272.96 | 74,685 | 20,386,047 | 15,891,638 | Jan 29, 2014, 08:20 AM |
| McCorkle Douglas S | VP Controller and Asst Treasur | Jan 14, 2014 | Sale | $290.00 | 4,000 | 1,160,000 | 0 | Jan 14, 2014, 05:26 PM |
| GILMAN ALFRED G | Director | Jan 14, 2014 | Option Exercise | $18.61 | 5,000 | 93,050 | 5,000 | Jan 14, 2014, 05:25 PM |
| GILMAN ALFRED G | Director | Jan 14, 2014 | Sale | $300.00 | 5,000 | 1,500,000 | 0 | Jan 14, 2014, 05:25 PM |
| Powchik Peter | SVP Clinical Development & Reg | Dec 31, 2013 | Option Exercise | $276.09 | 27,332 | 7,546,092 | 68,122 | Jan 03, 2014, 04:10 PM |
| Powchik Peter | SVP Clinical Development & Reg | Dec 31, 2013 | Option Exercise | $30.63 | 48,000 | 1,470,240 | 73,447 | Jan 03, 2014, 04:10 PM |
| Powchik Peter | SVP Clinical Development & Reg | Jan 02, 2014 | Sale | $274.77 | 20,668 | 5,678,965 | 43,115 | Jan 03, 2014, 04:10 PM |
| Powchik Peter | SVP Clinical Development & Reg | Dec 24, 2013 | Option Exercise | $21.25 | 4,705 | 99,981 | 25,447 | Dec 26, 2013, 01:26 PM |
| YANCOPOULOS GEORGE | President Regeneron Laboratori | Dec 19, 2013 | Option Exercise | $21.25 | 4,705 | 99,981 | 1,068,343 | Dec 20, 2013, 05:54 PM |
| Powchik Peter | SVP Clinical Development & Reg | Dec 18, 2013 | Option Exercise | $264.86 | 162 | 42,907 | 21,014 | Dec 20, 2013, 05:54 PM |
| Powchik Peter | SVP Clinical Development & Reg | Dec 18, 2013 | Option Exercise | $21.25 | 295 | 6,269 | 21,037 | Dec 20, 2013, 05:54 PM |
| Powchik Peter | SVP Clinical Development & Reg | Dec 18, 2013 | Sale | $270.20 | 9,000 | 2,431,800 | 20,742 | Dec 20, 2013, 05:54 PM |
| Powchik Peter | SVP Clinical Development & Reg | Dec 20, 2013 | Sale | $271.09 | 133 | 36,055 | 20,742 | Dec 20, 2013, 05:54 PM |
| GOLDBERG MURRAY A | SVP Administration & Asst Secr | Dec 18, 2013 | Option Exercise | $21.25 | 4,705 | 99,981 | 63,102 | Dec 19, 2013, 09:49 PM |
| STAHL NEIL | SVP Research and Development S | Dec 18, 2013 | Option Exercise | $21.25 | 4,705 | 99,981 | 24,391 | Dec 19, 2013, 09:49 PM |
| Terifay Robert J | SVP Commercial | Dec 18, 2013 | Option Exercise | $21.25 | 4,705 | 99,981 | 20,029 | Dec 19, 2013, 09:48 PM |
| Van Plew Daniel P | SVP & General Mgr Industrial O | Dec 18, 2013 | Option Exercise | $21.25 | 4,705 | 99,981 | 15,441 | Dec 19, 2013, 09:48 PM |
| Powchik Peter | SVP Clinical Development & Reg | Dec 16, 2013 | Option Exercise | $272.73 | 21,617 | 5,895,605 | 33,412 | Dec 17, 2013, 04:16 PM |
| Powchik Peter | SVP Clinical Development & Reg | Dec 16, 2013 | Option Exercise | $107.14 | 30,625 | 3,281,056 | 38,503 | Dec 17, 2013, 04:16 PM |
| Powchik Peter | SVP Clinical Development & Reg | Dec 17, 2013 | Sale | $270.00 | 8 | 2,160 | 29,742 | Dec 17, 2013, 04:16 PM |
| STAHL NEIL | SVP Research and Development S | Dec 16, 2013 | Option Exercise | $272.73 | 9,302 | 2,536,935 | 19,686 | Dec 17, 2013, 04:09 PM |
| YANCOPOULOS GEORGE | Pres Regeneron Labs | Dec 16, 2013 | Option Exercise | $272.73 | 42,974 | 11,720,299 | 1,063,638 | Dec 17, 2013, 04:08 PM |
| GOLDBERG MURRAY A | SVP Administration & Asst Secr | Dec 16, 2013 | Option Exercise | $272.73 | 5,157 | 1,406,469 | 58,397 | Dec 17, 2013, 04:08 PM |
| YANCOPOULOS GEORGE | Pres Regeneron Labs | Dec 12, 2013 | Option Exercise | $273.06 | 9,382 | 2,561,849 | 1,106,840 | Dec 13, 2013, 04:29 PM |
| YANCOPOULOS GEORGE | Pres Regeneron Labs | Dec 12, 2013 | Option Exercise | $260.44 | 9,599 | 2,499,964 | 1,115,994 | Dec 13, 2013, 04:29 PM |
| VAGELOS P ROY | Chairman of the Board | Dec 02, 2013 | Sale | $296.11 | 95 | 28,130 | 2,257 | Dec 04, 2013, 07:34 PM |
| SING GEORGE L | Director | Nov 26, 2013 | Option Exercise | $15.01 | 10,000 | 150,100 | 122,772 | Nov 27, 2013, 04:22 PM |
| SING GEORGE L | Director | Nov 26, 2013 | Sale | $295.00 | 10,000 | 2,950,000 | 112,772 | Nov 27, 2013, 04:22 PM |
| GOLDSTEIN JOSEPH L | Director | Nov 06, 2013 | Sale | $300.74 | 1,000 | 300,740 | 3,000 | Nov 06, 2013, 04:17 PM |
| SCHLEIFER LEONARD S | President & CEO | Oct 01, 2013 | Option Exercise | $313.58 | 20,114 | 6,307,348 | 59,836 | Oct 03, 2013, 04:14 PM |
| SCHLEIFER LEONARD S | President & CEO | Oct 01, 2013 | Option Exercise | $111.01 | 29,276 | 3,249,929 | 69,562 | Oct 03, 2013, 04:14 PM |
| SCHLEIFER LEONARD S | President & CEO | Oct 02, 2013 | Sale | $313.82 | 9,162 | 2,875,253 | 49,875 | Oct 03, 2013, 04:14 PM |
| BAKER CHARLES A | Director | Sep 30, 2013 | Option Exercise | $19.69 | 15,000 | 295,350 | 24,000 | Oct 02, 2013, 04:23 PM |
| BAKER CHARLES A | Director | Sep 30, 2013 | Sale | $314.03 | 15,000 | 4,710,439 | 23,700 | Oct 02, 2013, 04:23 PM |
| BROWN MICHAEL S | Director | Sep 25, 2013 | Option Exercise | $33.42 | 5,000 | 167,100 | 19,662 | Sep 27, 2013, 04:07 PM |
| BROWN MICHAEL S | Director | Sep 26, 2013 | Option Exercise | $33.42 | 5,000 | 167,100 | 19,662 | Sep 27, 2013, 04:07 PM |
| BROWN MICHAEL S | Director | Sep 26, 2013 | Sale | $309.00 | 5,000 | 1,545,000 | 14,662 | Sep 27, 2013, 04:07 PM |
| BROWN MICHAEL S | Director | Sep 25, 2013 | Sale | $293.64 | 5,000 | 1,468,222 | 17,362 | Sep 27, 2013, 04:07 PM |
| VAGELOS P ROY | Chairman of the Board | Sep 18, 2013 | Option Exercise | $304.38 | 167,144 | 50,875,292 | 364,913 | Sep 20, 2013, 04:33 PM |
| VAGELOS P ROY | Chairman of the Board | Sep 18, 2013 | Option Exercise | $13.00 | 312,500 | 4,062,500 | 378,259 | Sep 20, 2013, 04:33 PM |
| VAGELOS P ROY | Chairman of the Board | Sep 19, 2013 | Sale | $302.86 | 145,356 | 44,022,359 | 149,956 | Sep 20, 2013, 04:33 PM |
| SCHLEIFER LEONARD S | President & CEO | Sep 18, 2013 | Option Exercise | $304.38 | 115,440 | 35,137,628 | 253,668 | Sep 20, 2013, 04:25 PM |
| SCHLEIFER LEONARD S | President & CEO | Sep 18, 2013 | Option Exercise | $9.49 | 218,389 | 2,072,512 | 260,476 | Sep 20, 2013, 04:25 PM |
| SCHLEIFER LEONARD S | President & CEO | Sep 19, 2013 | Sale | $302.67 | 102,949 | 31,159,181 | 108,702 | Sep 20, 2013, 04:25 PM |
| ROBERTS WILLIAM | VP Reg Dev & Med Safety | Sep 18, 2013 | Option Exercise | $16.80 | 15,000 | 252,000 | 35,644 | Sep 20, 2013, 04:24 PM |
| ROBERTS WILLIAM | VP Reg Dev & Med Safety | Sep 18, 2013 | Sale | $304.00 | 15,000 | 4,560,000 | 20,644 | Sep 20, 2013, 04:24 PM |
| Van Plew Daniel P | SVP & Gen Mgr IOPS | Sep 17, 2013 | Option Exercise | $294.75 | 28,523 | 8,407,154 | 60,244 | Sep 19, 2013, 05:16 PM |
| Van Plew Daniel P | SVP & Gen Mgr IOPS | Sep 17, 2013 | Option Exercise | $16.80 | 52,500 | 882,000 | 63,236 | Sep 19, 2013, 05:16 PM |
| Van Plew Daniel P | SVP & Gen Mgr IOPS | Sep 18, 2013 | Sale | $303.17 | 23,977 | 7,269,042 | 30,936 | Sep 19, 2013, 05:16 PM |
| SCHLEIFER LEONARD S | CEO & President | Sep 09, 2013 | Sale | $275.47 | 5,000 | 1,377,332 | 1,400 | Sep 11, 2013, 04:05 PM |
| RYAN ARTHUR F | Director | Aug 22, 2013 | Option Exercise | $236.64 | 4,042 | 956,499 | 60,813 | Aug 26, 2013, 10:26 AM |
| RYAN ARTHUR F | Director | Aug 22, 2013 | Option Exercise | $31.90 | 30,000 | 956,900 | 62,019 | Aug 26, 2013, 10:26 AM |
| RYAN ARTHUR F | Director | Aug 23, 2013 | Sale | $238.47 | 10,958 | 2,613,154 | 49,855 | Aug 26, 2013, 10:26 AM |
| GOLDSTEIN JOSEPH L | Director | Aug 23, 2013 | Sale | $238.29 | 1,000 | 238,290 | 4,000 | Aug 23, 2013, 05:32 PM |
| GOLDBERG MURRAY A | SVP Finance and Admin CFO and | Aug 01, 2013 | Option Exercise | $16.80 | 5,000 | 84,000 | 63,554 | Aug 02, 2013, 11:37 AM |
| Aberman Michael S | VP Strategy and Investor Relat | Jun 17, 2013 | Option Exercise | $24.00 | 3,900 | 93,600 | 15,600 | Jun 18, 2013, 09:08 AM |
| BAKER CHARLES A | Director | Jun 10, 2013 | Option Exercise | $15.80 | 15,000 | 237,000 | 24,000 | Jun 12, 2013, 09:15 AM |
| BAKER CHARLES A | Director | Jun 10, 2013 | Sale | $251.84 | 15,000 | 3,777,547 | 19,850 | Jun 12, 2013, 09:15 AM |
| RYAN ARTHUR F | Director | May 31, 2013 | Sale | $249.55 | 2,500 | 623,885 | 35,355 | May 31, 2013, 04:09 PM |
| GOLDSTEIN JOSEPH L | Director | May 28, 2013 | Sale | $252.20 | 4,000 | 1,008,800 | 0 | May 28, 2013, 04:08 PM |
| GOLDBERG MURRAY A | SVP Finance and Admin CFO and | May 21, 2013 | Sale | $259.74 | 66,835 | 17,359,652 | 123,612 |