. (OPHT)
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As of 12/31/69 07:00 PM EST. Market closed.
. (OPHT)
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Market Cap: -
As of 12/31/69 07:00 PM EST. Market closed.
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INSIDER TRANSACTIONS FOR
| Owner | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| Westby Keith | SVP, Chief Operating Officer | Jul 03, 2023 | Option Exercise | $2.94 | 20,000 | 58,800 | 59,652 | Jul 06, 2023, 06:45 PM |
| Westby Keith | SVP, Chief Operating Officer | Jul 03, 2023 | Sale | $39.45 | 20,000 | 789,000 | 39,652 | Jul 06, 2023, 06:45 PM |
| SBLENDORIO GLENN | Chief Executive Officer | Jun 22, 2023 | Option Exercise | $13.22 | 11,084 | 146,486 | 239,275 | Jun 26, 2023, 04:44 PM |
| Westby Keith | SVP, Chief Operating Officer | Jun 02, 2023 | Option Exercise | $2.94 | 20,000 | 58,800 | 59,652 | Jun 06, 2023, 04:53 PM |
| Westby Keith | SVP, Chief Operating Officer | Jun 02, 2023 | Sale | $37.87 | 20,000 | 757,400 | 39,652 | Jun 06, 2023, 04:53 PM |
| Westby Keith | SVP, Chief Operating Officer | May 02, 2023 | Option Exercise | $2.94 | 20,000 | 58,800 | 59,652 | May 03, 2023, 05:31 PM |
| Westby Keith | SVP, Chief Operating Officer | May 01, 2023 | Option Exercise | $4.91 | 20,000 | 98,250 | 50,866 | May 03, 2023, 05:31 PM |
| Westby Keith | SVP, Chief Operating Officer | May 02, 2023 | Sale | $37.81 | 20,000 | 756,200 | 39,652 | May 03, 2023, 05:31 PM |
| Westby Keith | SVP, Chief Operating Officer | May 01, 2023 | Sale | $37.12 | 20,000 | 742,400 | 39,652 | May 03, 2023, 05:31 PM |
| Carroll David Francis | SVP, Chief Financial Officer | May 01, 2023 | Option Exercise | $2.81 | 63,500 | 178,435 | 131,972 | May 03, 2023, 05:31 PM |
| Carroll David Francis | SVP, Chief Financial Officer | May 01, 2023 | Sale | $37.04 | 63,500 | 2,352,040 | 68,472 | May 03, 2023, 05:31 PM |
| Carroll David Francis | SVP, Chief Financial Officer | Apr 24, 2023 | Option Exercise | $1.45 | 48,171 | 69,848 | 116,643 | Apr 25, 2023, 07:27 PM |
| Carroll David Francis | SVP, Chief Financial Officer | Apr 21, 2023 | Option Exercise | $1.45 | 1,829 | 2,652 | 70,301 | Apr 25, 2023, 07:27 PM |
| Carroll David Francis | SVP, Chief Financial Officer | Apr 24, 2023 | Sale | $30.21 | 48,171 | 1,455,246 | 68,472 | Apr 25, 2023, 07:27 PM |
| Carroll David Francis | SVP, Chief Financial Officer | Apr 21, 2023 | Sale | $30.00 | 1,829 | 54,870 | 68,472 | Apr 25, 2023, 07:27 PM |
| Westby Keith | SVP, Chief Operating Officer | Apr 21, 2023 | Option Exercise | $4.52 | 1,218 | 5,505 | 40,870 | Apr 25, 2023, 07:25 PM |
| Westby Keith | SVP, Chief Operating Officer | Apr 24, 2023 | Option Exercise | $4.52 | 18,782 | 84,895 | 58,434 | Apr 25, 2023, 07:25 PM |
| Westby Keith | SVP, Chief Operating Officer | Apr 21, 2023 | Sale | $30.00 | 1,218 | 36,540 | 39,652 | Apr 25, 2023, 07:25 PM |
| Westby Keith | SVP, Chief Operating Officer | Apr 24, 2023 | Sale | $30.07 | 18,782 | 564,775 | 39,652 | Apr 25, 2023, 07:25 PM |
| Westby Keith | SVP, Chief Operating Officer | Apr 03, 2023 | Option Exercise | $3.22 | 40,000 | 128,659 | 79,652 | Apr 05, 2023, 06:48 PM |
| Westby Keith | SVP, Chief Operating Officer | Apr 03, 2023 | Sale | $26.70 | 40,000 | 1,068,194 | 62,182 | Apr 05, 2023, 06:48 PM |
| Westby Keith | SVP, Chief Operating Officer | Mar 02, 2023 | Option Exercise | $1.45 | 13,298 | 19,282 | 59,652 | Mar 06, 2023, 04:34 PM |
| Westby Keith | SVP, Chief Operating Officer | Mar 02, 2023 | Sale | $23.93 | 20,000 | 478,614 | 40,252 | Mar 06, 2023, 04:34 PM |
| Westby Keith | SVP, Chief Operating Officer | Feb 17, 2023 | Option Exercise | $4.12 | 15,000 | 61,818 | 57,568 | Feb 22, 2023, 05:52 PM |
| Westby Keith | SVP, Chief Operating Officer | Feb 17, 2023 | Sale | $25.05 | 15,000 | 375,750 | 46,354 | Feb 22, 2023, 05:52 PM |
| Westby Keith | SVP, Chief Operating Officer | Feb 02, 2023 | Sale | $23.82 | 20,000 | 476,400 | 46,354 | Feb 03, 2023, 04:26 PM |
| Westby Keith | SVP, Chief Operating Officer | Feb 01, 2023 | Sale | $23.03 | 20,000 | 460,600 | 66,354 | Feb 03, 2023, 04:26 PM |
| Westby Keith | SVP, Chief Operating Officer | Jan 03, 2023 | Sale | $20.06 | 3,480 | 69,809 | 86,354 | Jan 04, 2023, 06:34 PM |
| SBLENDORIO GLENN | Chief Executive Officer | Jan 03, 2023 | Sale | $20.06 | 17,447 | 349,987 | 228,191 | Jan 04, 2023, 06:34 PM |
| Carroll David Francis | SVP, Chief Financial Officer | Jan 03, 2023 | Sale | $20.06 | 3,602 | 72,256 | 68,472 | Jan 04, 2023, 06:33 PM |
| Simms Christopher Paul | SVP, Chief Commercial Officer | Jan 03, 2023 | Sale | $20.06 | 2,368 | 47,502 | 32,429 | Jan 04, 2023, 06:33 PM |
| SBLENDORIO GLENN | CEO | Dec 19, 2022 | Sale | $21.51 | 19,457 | 418,520 | 244,138 | Dec 20, 2022, 07:02 PM |
| Westby Keith | SVP & COO | Dec 19, 2022 | Sale | $21.51 | 6,740 | 144,977 | 81,084 | Dec 20, 2022, 07:02 PM |
| Carroll David Francis | CFO | Dec 19, 2022 | Sale | $21.51 | 5,671 | 121,983 | 63,324 | Dec 20, 2022, 07:01 PM |
| Westby Keith | SVP & COO | Dec 13, 2022 | Sale | $21.73 | 6,741 | 146,482 | 75,324 | Dec 13, 2022, 09:02 PM |
| Westby Keith | SVP & COO | Dec 12, 2022 | Sale | $20.89 | 5,393 | 112,662 | 71,671 | Dec 13, 2022, 09:02 PM |
| Carroll David Francis | CFO | Dec 12, 2022 | Sale | $20.89 | 3,946 | 82,434 | 48,593 | Dec 13, 2022, 09:01 PM |
| Carroll David Francis | CFO | Dec 13, 2022 | Sale | $21.73 | 4,932 | 107,172 | 54,620 | Dec 13, 2022, 09:01 PM |
| Westby Keith | SVP & COO | Dec 02, 2022 | Option Exercise | $10.03 | 5,199 | 52,146 | 64,958 | Dec 05, 2022, 05:37 PM |
| Westby Keith | SVP & COO | Dec 01, 2022 | Sale | $22.96 | 10,030 | 230,289 | 59,759 | Dec 05, 2022, 05:37 PM |
| Dugel Pravin | President | Nov 17, 2022 | Option Exercise | $10.03 | 8,474 | 84,994 | 122,473 | Nov 21, 2022, 07:48 PM |
| SBLENDORIO GLENN | CEO | Nov 02, 2022 | Sale | $23.01 | 50,000 | 1,150,500 | 179,689 | Nov 04, 2022, 05:01 PM |
| Westby Keith | SVP & COO | Nov 01, 2022 | Option Exercise | $1.45 | 42,916 | 62,228 | 142,044 | Nov 03, 2022, 08:00 PM |
| Westby Keith | SVP & COO | Nov 01, 2022 | Sale | $23.92 | 72,916 | 1,744,151 | 69,128 | Nov 03, 2022, 08:00 PM |
| Simms Christopher Paul | SVP, Chief Commercial Officer | Aug 03, 2022 | Sale | $11.25 | 12,272 | 138,060 | 35,365 | Aug 04, 2022, 04:09 PM |
| Gibney Anthony S | EVP, Chief Business Officer | Jul 05, 2022 | Sale | $9.41 | 7,791 | 73,313 | 10,959 | Jul 05, 2022, 06:30 PM |
| Roberts Calvin W. | Director | Jun 13, 2022 | Buy | $9.62 | 25,000 | 240,500 | 32,500 | Jun 14, 2022, 04:55 PM |
| Westby Keith | SVP & COO | Apr 18, 2022 | Sale | $16.63 | 10,000 | 166,300 | 99,128 | Apr 20, 2022, 04:51 PM |
| Westby Keith | SVP & COO | Apr 04, 2022 | Option Exercise | $1.45 | 20,702 | 30,018 | 129,830 | Apr 06, 2022, 06:13 PM |
| Westby Keith | SVP & COO | Apr 05, 2022 | Option Exercise | $1.45 | 9,298 | 13,482 | 118,426 | Apr 06, 2022, 06:13 PM |
| Westby Keith | SVP & COO | Apr 04, 2022 | Sale | $19.00 | 20,702 | 393,346 | 109,128 | Apr 06, 2022, 06:13 PM |
| Westby Keith | SVP & COO | Apr 05, 2022 | Sale | $19.02 | 9,298 | 176,808 | 109,128 | Apr 06, 2022, 06:13 PM |
| SBLENDORIO GLENN | CEO | Apr 04, 2022 | Sale | $18.76 | 50,000 | 937,805 | 229,689 | Apr 06, 2022, 06:11 PM |
| Carroll David Francis | CFO | Apr 04, 2022 | Option Exercise | $1.45 | 20,316 | 29,458 | 81,107 | Apr 05, 2022, 06:25 PM |
| Carroll David Francis | CFO | Apr 05, 2022 | Option Exercise | $1.45 | 4,684 | 6,792 | 44,850 | Apr 05, 2022, 06:25 PM |
| Carroll David Francis | CFO | Apr 01, 2022 | Sale | $17.00 | 2,144 | 36,448 | 60,791 | Apr 05, 2022, 06:25 PM |
| Carroll David Francis | CFO | Apr 05, 2022 | Sale | $19.01 | 4,684 | 89,043 | 40,166 | Apr 05, 2022, 06:25 PM |
| Carroll David Francis | CFO | Apr 04, 2022 | Sale | $18.50 | 40,941 | 757,311 | 40,766 | Apr 05, 2022, 06:25 PM |
| SBLENDORIO GLENN | CEO | Mar 30, 2022 | Option Exercise | $2.94 | 1,213 | 3,566 | 280,902 | Apr 01, 2022, 07:03 PM |
| SBLENDORIO GLENN | CEO | Apr 01, 2022 | Option Exercise | $2.94 | 40,756 | 119,823 | 320,445 | Apr 01, 2022, 07:03 PM |
| SBLENDORIO GLENN | CEO | Mar 31, 2022 | Option Exercise | $2.94 | 1,400 | 4,116 | 281,089 | Apr 01, 2022, 07:03 PM |
| SBLENDORIO GLENN | CEO | Apr 01, 2022 | Sale | $17.50 | 40,756 | 713,230 | 279,689 | Apr 01, 2022, 07:03 PM |
| SBLENDORIO GLENN | CEO | Mar 31, 2022 | Sale | $17.02 | 1,400 | 23,828 | 279,689 | Apr 01, 2022, 07:03 PM |
| SBLENDORIO GLENN | CEO | Mar 30, 2022 | Sale | $17.00 | 1,213 | 20,626 | 279,689 | Apr 01, 2022, 07:03 PM |
| Carroll David Francis | CFO | Mar 25, 2022 | Option Exercise | $1.45 | 16,763 | 24,306 | 79,707 | Mar 29, 2022, 07:45 PM |
| Carroll David Francis | CFO | Mar 25, 2022 | Sale | $17.02 | 16,772 | 285,387 | 62,935 | Mar 29, 2022, 07:45 PM |
| SBLENDORIO GLENN | CEO | Mar 25, 2022 | Option Exercise | $2.94 | 18,775 | 55,199 | 298,464 | Mar 29, 2022, 07:44 PM |
| SBLENDORIO GLENN | CEO | Mar 25, 2022 | Sale | $17.06 | 18,775 | 320,301 | 279,689 | Mar 29, 2022, 07:44 PM |
| Carroll David Francis | CFO | Mar 18, 2022 | Option Exercise | $1.45 | 8,237 | 11,944 | 74,505 | Mar 22, 2022, 04:44 PM |
| Carroll David Francis | CFO | Mar 18, 2022 | Sale | $17.00 | 11,561 | 196,562 | 62,944 | Mar 22, 2022, 04:44 PM |
| SBLENDORIO GLENN | CEO | Mar 18, 2022 | Option Exercise | $2.94 | 3,479 | 10,228 | 283,168 | Mar 22, 2022, 04:43 PM |
| SBLENDORIO GLENN | CEO | Mar 18, 2022 | Sale | $17.00 | 3,479 | 59,145 | 279,689 | Mar 22, 2022, 04:43 PM |
| Westby Keith | SVP & COO | Mar 17, 2022 | Sale | $15.06 | 2,143 | 32,280 | 109,128 | Mar 18, 2022, 04:21 PM |
| Westby Keith | SVP & COO | Mar 16, 2022 | Sale | $15.01 | 7,857 | 117,911 | 111,271 | Mar 18, 2022, 04:21 PM |
| Westby Keith | SVP & COO | Mar 01, 2022 | Option Exercise | $1.65 | 10,169 | 16,799 | 118,449 | Mar 02, 2022, 04:50 PM |
| Westby Keith | SVP & COO | Feb 15, 2022 | Sale | $15.16 | 10,000 | 151,634 | 108,280 | Feb 17, 2022, 04:03 PM |
| Westby Keith | SVP & COO | Feb 07, 2022 | Sale | $15.00 | 10,000 | 150,033 | 118,280 | Feb 08, 2022, 08:13 PM |
| Westby Keith | SVP & COO | Jan 03, 2022 | Sale | $16.39 | 12,278 | 201,265 | 128,280 | Jan 04, 2022, 05:09 PM |
| Carroll David Francis | SVP, CFO and Treasurer | Jan 03, 2022 | Sale | $16.39 | 15,819 | 259,310 | 65,504 | Jan 04, 2022, 05:08 PM |
| SBLENDORIO GLENN | CEO | Dec 30, 2021 | Option Exercise | $2.94 | 100 | 294 | 279,233 | Jan 03, 2022, 05:58 PM |
| SBLENDORIO GLENN | CEO | Dec 31, 2021 | Option Exercise | $2.94 | 801 | 2,355 | 279,934 | Jan 03, 2022, 05:58 PM |
| SBLENDORIO GLENN | CEO | Dec 31, 2021 | Sale | $17.00 | 801 | 13,621 | 279,133 | Jan 03, 2022, 05:58 PM |
| SBLENDORIO GLENN | CEO | Dec 30, 2021 | Sale | $17.01 | 100 | 1,701 | 279,133 | Jan 03, 2022, 05:58 PM |
| SBLENDORIO GLENN | CEO | Dec 22, 2021 | Option Exercise | $1.45 | 22,163 | 32,136 | 361,296 | Dec 27, 2021, 08:58 PM |
| SBLENDORIO GLENN | CEO | Dec 27, 2021 | Option Exercise | $1.45 | 5,229 | 7,582 | 284,362 | Dec 27, 2021, 08:58 PM |
| SBLENDORIO GLENN | CEO | Dec 23, 2021 | Option Exercise | $1.86 | 31,084 | 57,701 | 370,217 | Dec 27, 2021, 08:58 PM |
| SBLENDORIO GLENN | CEO | Dec 27, 2021 | Sale | $16.64 | 5,229 | 86,990 | 279,133 | Dec 27, 2021, 08:58 PM |
| SBLENDORIO GLENN | CEO | Dec 23, 2021 | Sale | $16.96 | 31,084 | 527,135 | 339,133 | Dec 27, 2021, 08:58 PM |
| SBLENDORIO GLENN | CEO | Dec 22, 2021 | Sale | $16.50 | 22,163 | 365,783 | 339,133 | Dec 27, 2021, 08:58 PM |
| Westby Keith | SVP & COO | Dec 21, 2021 | Sale | $15.89 | 20,000 | 317,744 | 108,058 | Dec 23, 2021, 04:02 PM |
| Carroll David Francis | SVP, CFO and Treasurer | Dec 21, 2021 | Sale | $15.98 | 56,207 | 898,334 | 48,823 | Dec 23, 2021, 04:01 PM |
| Westby Keith | SVP & COO | Dec 20, 2021 | Sale | $15.44 | 4,516 | 69,743 | 128,058 | Dec 21, 2021, 06:05 PM |
| Carroll David Francis | SVP, CFO and Treasurer | Dec 20, 2021 | Sale | $15.44 | 6,710 | 103,626 | 105,030 | Dec 21, 2021, 06:03 PM |
| SBLENDORIO GLENN | CEO | Dec 20, 2021 | Sale | $15.44 | 18,524 | 286,075 | 339,133 | Dec 21, 2021, 06:02 PM |
| Westby Keith | SVP & COO | Dec 13, 2021 | Sale | $14.74 | 4,517 | 66,603 | 120,074 | Dec 14, 2021, 06:08 PM |
| Carroll David Francis | SVP, CFO and Treasurer | Dec 13, 2021 | Sale | $14.74 | 5,836 | 86,051 | 97,365 | Dec 14, 2021, 06:08 PM |
| SBLENDORIO GLENN | Chief Executive Officer | Dec 13, 2021 | Sale | $14.74 | 8,293 | 122,279 | 320,999 | Dec 14, 2021, 06:07 PM |
| Westby Keith | SVP & COO | Dec 10, 2021 | Sale | $14.53 | 3,614 | 52,517 | 112,091 | Dec 13, 2021, 07:52 PM |
| Carroll David Francis | SVP, CFO and Treasurer | Dec 10, 2021 | Sale | $14.53 | 3,614 | 52,517 | 90,701 | Dec 13, 2021, 07:49 PM |
| Simms Christopher Paul | SVP, Chief Commercial Officer | Nov 18, 2021 | Buy | $16.30 | 3,069 | 50,025 | 7,069 | Nov 22, 2021, 04:02 PM |
| Dugel Pravin | President | Nov 11, 2021 | Option Exercise | $1.65 | 4,237 | 7,000 | 45,936 | Nov 15, 2021, 04:01 PM |
| Dugel Pravin | EVP, Chief Strategy & Business | Apr 05, 2021 | Sale | $6.34 | 28,301 | 179,428 | 41,699 | Apr 05, 2021, 09:30 PM |
| Westby Keith | SVP & COO | Jan 04, 2021 | Sale | $6.85 | 11,875 | 81,344 | 86,466 | Jan 05, 2021, 04:05 PM |
| Carroll David Francis | SVP, CFO and Treasurer | Jan 04, 2021 | Sale | $6.85 | 11,875 | 81,344 | 80,165 | Jan 05, 2021, 04:02 PM |
| Westby Keith | SVP & COO | Dec 14, 2020 | Sale | $7.16 | 4,527 | 32,413 | 65,841 | Dec 15, 2020, 02:49 PM |
| GUYER DAVID R | Executive Chairman | Dec 14, 2020 | Sale | $7.16 | 9,270 | 66,373 | 70,113 | Dec 15, 2020, 02:48 PM |
| Westby Keith | SVP & COO | Dec 10, 2020 | Sale | $6.96 | 3,676 | 25,585 | 57,868 | Dec 11, 2020, 09:04 PM |
| GUYER DAVID R | Executive Chairman | Dec 10, 2020 | Sale | $6.96 | 9,602 | 66,830 | 62,183 | Dec 11, 2020, 08:59 PM |
| Westby Keith | SVP & COO | Jan 06, 2020 | Sale | $8.07 | 293 | 2,365 | 40,983 | Jan 07, 2020, 07:31 PM |
| GUYER DAVID R | Executive Chairman | Jan 06, 2020 | Sale | $8.07 | 3,367 | 27,172 | 53,972 | Jan 07, 2020, 07:31 PM |
| GUYER DAVID R | Executive Chairman | Dec 13, 2019 | Sale | $6.60 | 9,275 | 61,215 | 51,089 | Dec 16, 2019, 05:25 PM |
| Westby Keith | SVP & COO | Dec 13, 2019 | Sale | $6.60 | 4,530 | 29,898 | 40,576 | Dec 16, 2019, 05:25 PM |
| SBLENDORIO GLENN | President and CEO | Dec 10, 2019 | Buy | $4.00 | 62,500 | 250,000 | 176,854 | Dec 11, 2019, 06:54 PM |
| SBLENDORIO GLENN | President and CEO | Nov 15, 2019 | Buy | $3.12 | 15,000 | 46,851 | 114,354 | Nov 18, 2019, 05:45 PM |
| Carroll David Francis | SVP, CFO and Treasurer | Jul 02, 2019 | Sale | $1.25 | 2,773 | 3,466 | 13,707 | Jul 03, 2019, 04:00 PM |
| SBLENDORIO GLENN | President and CEO | May 10, 2019 | Buy | $1.48 | 25,000 | 37,000 | 93,105 | May 13, 2019, 04:09 PM |
| SBLENDORIO GLENN | President and CEO | Apr 02, 2019 | Sale | $1.43 | 6,914 | 9,887 | 68,105 | Apr 03, 2019, 06:11 PM |
| Versant Venture Capital IV, L.P. | 10% Owner | Jan 14, 2019 | Option Exercise | $2.30 | 130,526 | 300,001 | 5,142,333 | Jan 16, 2019, 02:29 PM |
| Westby Keith | SVP & COO | Jan 07, 2019 | Sale | $1.30 | 299 | 389 | 32,606 | Jan 07, 2019, 08:36 PM |
| GUYER DAVID R | Executive Chairman | Jan 07, 2019 | Sale | $1.30 | 3,859 | 5,017 | 43,164 | Jan 07, 2019, 08:34 PM |
| Westby Keith | SVP & COO | Jan 03, 2019 | Sale | $1.24 | 342 | 424 | 32,205 | Jan 04, 2019, 06:28 PM |
| GUYER DAVID R | Executive Chairman | Jan 03, 2019 | Sale | $1.24 | 3,637 | 4,510 | 40,773 | Jan 04, 2019, 06:26 PM |
| Carroll David Francis | SVP, CFO and Treasurer | Jul 02, 2018 | Sale | $2.68 | 2,736 | 7,332 | 8,980 | Jul 03, 2018, 05:10 PM |
| SBLENDORIO GLENN | President and CEO | Apr 02, 2018 | Sale | $2.69 | 6,838 | 18,394 | 48,407 | Apr 03, 2018, 07:06 PM |
| WOOD BARBARA A | SVP, Gen. Counsel, Secretary | Jan 05, 2018 | Sale | $3.17 | 602 | 1,908 | 16,462 | Jan 05, 2018, 05:22 PM |
| Westby Keith | SVP & COO | Jan 05, 2018 | Sale | $3.17 | 317 | 1,005 | 24,983 | Jan 05, 2018, 05:22 PM |
| GUYER DAVID R | Executive Chairman | Jan 05, 2018 | Sale | $3.17 | 3,798 | 12,040 | 38,660 | Jan 05, 2018, 05:21 PM |
| GUYER DAVID R | Executive Chairman | Jan 03, 2018 | Sale | $3.24 | 3,516 | 11,392 | 36,208 | Jan 04, 2018, 05:13 PM |
| WOOD BARBARA A | SVP, General Counsel,Secretary | Jan 03, 2018 | Sale | $3.24 | 694 | 2,249 | 15,864 | Jan 04, 2018, 05:09 PM |
| Westby Keith | SVP & COO | Jan 03, 2018 | Sale | $3.24 | 356 | 1,153 | 24,600 | Jan 04, 2018, 05:08 PM |
| GUYER DAVID R | Executive Chairman | Jan 02, 2018 | Sale | $3.19 | 16,520 | 52,699 | 33,974 | Jan 03, 2018, 05:00 PM |
| WOOD BARBARA A | SVP,General Counsel,Secretary | Jan 02, 2018 | Sale | $3.19 | 5,289 | 16,872 | 15,183 | Jan 03, 2018, 12:00 AM |
| SBLENDORIO GLENN | President and CEO | Jan 02, 2018 | Sale | $3.19 | 8,089 | 25,804 | 36,495 | Jan 03, 2018, 12:00 AM |
| Carroll David Francis | SVP, CFO and Treasurer | Jul 05, 2017 | Sale | $2.58 | 3,284 | 8,473 | 4,216 | Jul 05, 2017, 06:35 PM |
| GUYER DAVID R | Executive Chairman | Jul 05, 2017 | Sale | $2.58 | 17,678 | 45,609 | 20,014 | Jul 05, 2017, 06:34 PM |
| WOOD BARBARA A | SVP,General Counsel,Secretary | Jul 05, 2017 | Sale | $2.58 | 5,119 | 13,207 | 8,332 | Jul 05, 2017, 06:33 PM |
| SBLENDORIO GLENN | President and CEO | Jul 05, 2017 | Sale | $2.58 | 7,828 | 20,196 | 24,164 | Jul 05, 2017, 06:31 PM |
| Redlick David E | Director | Jun 13, 2017 | Sale | $2.52 | 700 | 1,764 | 1,050 | Jun 14, 2017, 07:17 PM |
| SBLENDORIO GLENN | President, CFO and Treasurer | Apr 03, 2017 | Sale | $3.56 | 7,388 | 26,301 | 11,572 | Apr 04, 2017, 07:10 PM |
| Bolte Axel | Director | Dec 30, 2016 | Sale | $4.83 | 6,000 | 28,980 | 0 | Jan 23, 2017, 05:05 PM |
| WOOD BARBARA A | SVP,General Counsel,Secretary | Jan 05, 2017 | Sale | $4.96 | 589 | 2,921 | 1,311 | Jan 06, 2017, 05:14 PM |
| GUYER DAVID R | Chief Executive Officer | Jan 05, 2017 | Sale | $4.96 | 3,785 | 18,774 | 7,212 | Jan 06, 2017, 05:14 PM |
| PATEL SAMIR CHANDRAKANT | President | Jan 05, 2017 | Sale | $4.96 | 3,844 | 19,066 | 16,628 | Jan 06, 2017, 05:13 PM |
| Bjarke Henric Bjorn | SVP & CCO | Jan 05, 2017 | Sale | $4.96 | 316 | 1,567 | 1,384 | Jan 06, 2017, 05:12 PM |
| PATEL SAMIR CHANDRAKANT | President | Jan 03, 2017 | Sale | $4.90 | 2,999 | 14,695 | 13,407 | Jan 04, 2017, 05:06 PM |
| GUYER DAVID R | Chief Executive Officer | Jan 03, 2017 | Sale | $4.90 | 3,484 | 17,072 | 4,747 | Jan 04, 2017, 05:06 PM |
| WOOD BARBARA A | SVP, General Counsel,Secretary | Jan 03, 2017 | Sale | $4.90 | 675 | 3,308 | 700 | Jan 04, 2017, 05:05 PM |
| WOOD BARBARA A | SVP,General Counsel,Secretary | Dec 23, 2016 | Sale | $4.92 | 746 | 3,670 | 0 | Dec 27, 2016, 05:10 PM |
| SBLENDORIO GLENN | EVP, COO & CFO, Treasurer | Dec 22, 2016 | Sale | $4.85 | 1,079 | 5,236 | 0 | Dec 23, 2016, 05:05 PM |
| Novo A/S | 10% Owner | Dec 15, 2016 | Sale | $4.72 | 1,405,487 | 6,636,007 | 0 | Dec 16, 2016, 06:29 PM |
| Novo A/S | 10% Owner | Dec 14, 2016 | Sale | $4.97 | 2,205,000 | 10,962,378 | 1,405,487 | Dec 16, 2016, 06:29 PM |
| GUYER DAVID R | Chief Executive Officer | Nov 01, 2016 | Option Exercise | $10.03 | 22,060 | 221,262 | 24,541 | Nov 03, 2016, 09:35 PM |
| GUYER DAVID R | Chief Executive Officer | Nov 01, 2016 | Sale | $35.61 | 22,060 | 785,638 | 14,011 | Nov 03, 2016, 09:35 PM |
| GUYER DAVID R | Chief Executive Officer | Oct 03, 2016 | Option Exercise | $10.03 | 16,210 | 162,586 | 24,541 | Oct 05, 2016, 05:16 PM |
| GUYER DAVID R | Chief Executive Officer | Oct 03, 2016 | Sale | $44.37 | 22,060 | 978,899 | 10,713 | Oct 05, 2016, 05:16 PM |
| PATEL SAMIR CHANDRAKANT | President | Sep 29, 2016 | Sale | $55.17 | 20,000 | 1,103,345 | 24,239 | Oct 03, 2016, 05:14 PM |
| GUYER DAVID R | Chief Executive Officer | Sep 01, 2016 | Sale | $52.58 | 24,060 | 1,265,075 | 8,331 | Sep 06, 2016, 05:15 PM |
| PATEL SAMIR CHANDRAKANT | President | Aug 29, 2016 | Sale | $52.80 | 20,000 | 1,056,000 | 31,531 | Aug 31, 2016, 05:16 PM |
| GUYER DAVID R | Chief Executive Officer | Aug 01, 2016 | Option Exercise | $10.03 | 24,060 | 241,322 | 56,451 | Aug 03, 2016, 05:01 PM |
| GUYER DAVID R | Chief Executive Officer | Aug 01, 2016 | Sale | $64.47 | 24,060 | 1,551,103 | 35,196 | Aug 03, 2016, 05:01 PM |
| PATEL SAMIR CHANDRAKANT | President | Jul 29, 2016 | Sale | $64.21 | 20,000 | 1,284,185 | 176,031 | Aug 02, 2016, 05:00 PM |
| GUYER DAVID R | Chief Executive Officer | Jul 01, 2016 | Option Exercise | $10.03 | 24,060 | 241,322 | 56,451 | Jul 06, 2016, 05:15 PM |
| GUYER DAVID R | Chief Executive Officer | Jul 01, 2016 | Sale | $52.12 | 24,060 | 1,253,934 | 51,151 | Jul 06, 2016, 05:15 PM |
| PATEL SAMIR CHANDRAKANT | President | Jun 30, 2016 | Sale | $51.05 | 21,846 | 1,115,319 | 194,231 | Jul 01, 2016, 05:42 PM |
| PATEL SAMIR CHANDRAKANT | President | Jun 29, 2016 | Sale | $51.42 | 20,000 | 1,028,321 | 174,992 | Jul 01, 2016, 05:42 PM |
| Bolte Axel | Director | Jun 03, 2016 | Buy | $56.97 | 3,500 | 199,395 | 6,000 | Jun 07, 2016, 05:06 PM |
| GUYER DAVID R | Chief Executive Officer | Jun 01, 2016 | Option Exercise | $10.03 | 30,060 | 301,502 | 62,451 | Jun 03, 2016, 06:28 PM |
| GUYER DAVID R | Chief Executive Officer | Jun 01, 2016 | Sale | $52.71 | 30,060 | 1,584,505 | 36,685 | Jun 03, 2016, 06:28 PM |
| SBLENDORIO GLENN | EVP, COO & CFO, Treasurer | Jun 02, 2016 | Sale | $57.20 | 671 | 38,381 | 1,079 | Jun 03, 2016, 06:28 PM |
| PATEL SAMIR CHANDRAKANT | President | May 31, 2016 | Option Exercise | $13.22 | 1,185 | 15,661 | 213,377 | Jun 02, 2016, 05:22 PM |
| PATEL SAMIR CHANDRAKANT | President | May 31, 2016 | Sale | $53.32 | 20,000 | 1,066,431 | 211,703 | Jun 02, 2016, 05:22 PM |
| Novo A/S | 10% Owner | May 24, 2016 | Sale | $49.00 | 1,300,000 | 63,700,000 | 3,610,489 | May 25, 2016, 05:17 PM |
| GUYER DAVID R | Chief Executive Officer | May 02, 2016 | Option Exercise | $10.03 | 22,060 | 221,262 | 54,451 | May 04, 2016, 05:36 PM |
| GUYER DAVID R | Chief Executive Officer | May 02, 2016 | Sale | $46.18 | 22,060 | 1,018,738 | 37,030 | May 04, 2016, 05:36 PM |
| PATEL SAMIR CHANDRAKANT | President | Apr 29, 2016 | Option Exercise | $6.92 | 2,597 | 17,982 | 232,192 | May 03, 2016, 06:30 PM |
| PATEL SAMIR CHANDRAKANT | President | Apr 29, 2016 | Sale | $46.79 | 20,000 | 935,875 | 213,757 | May 03, 2016, 06:30 PM |
| GUYER DAVID R | Chief Executive Officer | Apr 01, 2016 | Option Exercise | $10.03 | 22,060 | 221,262 | 54,451 | Apr 05, 2016, 05:05 PM |
| GUYER DAVID R | Chief Executive Officer | Apr 01, 2016 | Sale | $44.11 | 22,060 | 972,984 | 52,341 | Apr 05, 2016, 05:05 PM |
| PATEL SAMIR CHANDRAKANT | President | Mar 29, 2016 | Option Exercise | $6.93 | 2,597 | 17,994 | 249,595 | Mar 31, 2016, 05:05 PM |
| PATEL SAMIR CHANDRAKANT | President | Mar 29, 2016 | Sale | $41.85 | 20,000 | 836,909 | 240,992 | Mar 31, 2016, 05:05 PM |
| GUYER DAVID R | Chief Executive Officer | Mar 01, 2016 | Option Exercise | $10.03 | 22,060 | 221,262 | 54,451 | Mar 03, 2016, 07:42 PM |
| GUYER DAVID R | Chief Executive Officer | Mar 01, 2016 | Sale | $45.48 | 22,060 | 1,003,310 | 51,451 | Mar 03, 2016, 07:42 PM |
| PATEL SAMIR CHANDRAKANT | President | Feb 29, 2016 | Option Exercise | $7.85 | 6,087 | 47,777 | 266,998 | Mar 02, 2016, 06:50 PM |
| PATEL SAMIR CHANDRAKANT | President | Feb 29, 2016 | Sale | $45.13 | 20,000 | 902,503 | 248,933 | Mar 02, 2016, 06:50 PM |
| PATEL SAMIR CHANDRAKANT | President | Jan 29, 2016 | Sale | $53.59 | 20,000 | 1,071,740 | 269,493 | Feb 02, 2016, 06:54 PM |
| GUYER DAVID R | Chief Executive Officer | Jan 28, 2016 | Option Exercise | $10.03 | 18,598 | 186,538 | 50,989 | Feb 01, 2016, 06:55 PM |
| GUYER DAVID R | Chief Executive Officer | Jan 28, 2016 | Sale | $53.63 | 18,598 | 997,375 | 36,791 | Feb 01, 2016, 06:55 PM |
| GALAKATOS NICHOLAS | Director | Jan 11, 2016 | Sale | $65.39 | 1,000 | 65,390 | 4,444 | Jan 13, 2016, 05:05 PM |
| GALAKATOS NICHOLAS | Director | Jan 11, 2016 | Sale | $65.89 | 2,000 | 131,781 | 6,685 | Jan 13, 2016, 05:05 PM |
| WOOD BARBARA A | SVP,General Counsel,Secretary | Jan 04, 2016 | Option Exercise | $24.49 | 1,000 | 24,490 | 1,746 | Jan 06, 2016, 05:23 PM |
| WOOD BARBARA A | SVP,General Counsel,Secretary | Jan 04, 2016 | Sale | $76.37 | 1,000 | 76,370 | 746 | Jan 06, 2016, 05:23 PM |
| GUYER DAVID R | Chief Executive Officer | Jan 04, 2016 | Sale | $72.54 | 3,269 | 237,140 | 34,798 | Jan 05, 2016, 05:10 PM |
| PATEL SAMIR CHANDRAKANT | President | Jan 04, 2016 | Sale | $72.54 | 2,569 | 186,361 | 282,803 | Jan 05, 2016, 05:08 PM |
| ATIEH MICHAEL G | EVP, CFO, & CBO, Treasurer | Jan 04, 2016 | Sale | $72.54 | 130 | 9,430 | 391 | Jan 05, 2016, 05:07 PM |
| WOOD BARBARA A | SVP,General Counsel,Secretary | Jan 04, 2016 | Sale | $72.54 | 629 | 45,629 | 1,209 | Jan 05, 2016, 05:05 PM |
| GUYER DAVID R | Chief Executive Officer | Dec 30, 2015 | Option Exercise | $10.03 | 18,582 | 186,377 | 48,492 | Jan 04, 2016, 05:36 PM |
| GUYER DAVID R | Chief Executive Officer | Dec 30, 2015 | Sale | $78.82 | 18,582 | 1,464,666 | 36,861 | Jan 04, 2016, 05:36 PM |
| SBLENDORIO GLENN | Director | Dec 30, 2015 | Option Exercise | $13.22 | 2,000 | 26,432 | 2,000 | Jan 04, 2016, 05:35 PM |
| SBLENDORIO GLENN | Director | Dec 30, 2015 | Sale | $80.00 | 2,000 | 160,000 | 0 | Jan 04, 2016, 05:35 PM |
| PATEL SAMIR CHANDRAKANT | President | Dec 29, 2015 | Option Exercise | $13.22 | 1,184 | 15,648 | 279,789 | Dec 31, 2015, 05:07 PM |
| PATEL SAMIR CHANDRAKANT | President | Dec 29, 2015 | Sale | $77.50 | 1,184 | 91,761 | 279,229 | Dec 31, 2015, 05:07 PM |
| PATEL SAMIR CHANDRAKANT | President | Dec 24, 2015 | Option Exercise | $20.88 | 26,036 | 543,716 | 304,641 | Dec 28, 2015, 05:10 PM |
| PATEL SAMIR CHANDRAKANT | President | Dec 24, 2015 | Sale | $77.09 | 26,036 | 2,007,101 | 295,541 | Dec 28, 2015, 05:10 PM |
| GALAKATOS NICHOLAS | Director | Dec 10, 2015 | Sale | $64.44 | 2,000 | 128,871 | 9,151 | Dec 14, 2015, 09:44 PM |
| GALAKATOS NICHOLAS | Director | Dec 10, 2015 | Sale | $64.44 | 1,000 | 64,438 | 5,678 | Dec 14, 2015, 09:44 PM |
| WOOD BARBARA A | SVP,General Counsel,Secretary | Dec 01, 2015 | Option Exercise | $24.49 | 2,000 | 48,980 | 2,000 | Dec 03, 2015, 05:05 PM |
| WOOD BARBARA A | SVP,General Counsel,Secretary | Dec 01, 2015 | Sale | $63.24 | 2,000 | 126,482 | 100 | Dec 03, 2015, 05:05 PM |
| GUYER DAVID R | Chief Executive Officer | Nov 30, 2015 | Option Exercise | $10.03 | 18,582 | 186,377 | 48,492 | Dec 02, 2015, 05:05 PM |
| GUYER DAVID R | Chief Executive Officer | Nov 30, 2015 | Sale | $62.49 | 18,582 | 1,161,132 | 46,121 | Dec 02, 2015, 05:05 PM |
| PATEL SAMIR CHANDRAKANT | President | Nov 24, 2015 | Option Exercise | $29.62 | 27,215 | 806,152 | 305,820 | Nov 25, 2015, 05:05 PM |
| PATEL SAMIR CHANDRAKANT | President | Nov 24, 2015 | Sale | $60.27 | 27,215 | 1,640,318 | 286,449 | Nov 25, 2015, 05:05 PM |
| GALAKATOS NICHOLAS | Director | Nov 18, 2015 | Sale | $60.00 | 500 | 30,000 | 5,945 | Nov 19, 2015, 05:38 PM |
| GALAKATOS NICHOLAS | Director | Nov 18, 2015 | Sale | $60.00 | 1,000 | 60,000 | 9,684 | Nov 19, 2015, 05:38 PM |
| GALAKATOS NICHOLAS | Director | Nov 09, 2015 | Sale | $60.00 | 500 | 30,000 | 6,945 | Nov 12, 2015, 05:11 PM |
| GALAKATOS NICHOLAS | Director | Nov 09, 2015 | Sale | $60.00 | 1,000 | 60,000 | 11,684 | Nov 12, 2015, 05:11 PM |
| GALAKATOS NICHOLAS | Director | Nov 10, 2015 | Sale | $58.69 | 500 | 29,345 | 6,445 | Nov 12, 2015, 05:11 PM |
| GALAKATOS NICHOLAS | Director | Nov 10, 2015 | Sale | $58.69 | 1,000 | 58,690 | 10,684 | Nov 12, 2015, 05:11 PM |
| PATEL SAMIR CHANDRAKANT | President | Nov 05, 2015 | Sale | $53.55 | 20,687 | 1,107,767 | 286,470 | Nov 06, 2015, 05:18 PM |
| GALAKATOS NICHOLAS | Director | Nov 02, 2015 | Sale | $54.00 | 500 | 27,000 | 7,445 | Nov 04, 2015, 05:28 PM |
| GALAKATOS NICHOLAS | Director | Nov 02, 2015 | Sale | $54.00 | 1,000 | 54,000 | 13,184 | Nov 04, 2015, 05:28 PM |
| GUYER DAVID R | Chief Executive Officer | Oct 30, 2015 | Option Exercise | $10.03 | 18,582 | 186,377 | 48,492 | Nov 03, 2015, 05:10 PM |
| GUYER DAVID R | Chief Executive Officer | Oct 30, 2015 | Sale | $49.88 | 18,582 | 926,909 | 30,010 | Nov 03, 2015, 05:10 PM |
| PATEL SAMIR CHANDRAKANT | President | Oct 21, 2015 | Option Exercise | $31.03 | 27,215 | 844,364 | 286,507 | Oct 23, 2015, 05:05 PM |
| PATEL SAMIR CHANDRAKANT | President | Oct 21, 2015 | Sale | $43.27 | 27,215 | 1,177,713 | 278,207 | Oct 23, 2015, 05:05 PM |
| WOOD BARBARA A | SVP,General Counsel,Secretary | Oct 16, 2015 | Option Exercise | $24.49 | 2,000 | 48,980 | 2,000 | Oct 19, 2015, 05:46 PM |
| WOOD BARBARA A | SVP,General Counsel,Secretary | Oct 16, 2015 | Sale | $45.00 | 2,000 | 90,000 | 0 | Oct 19, 2015, 05:46 PM |
| GUYER DAVID R | Chief Executive Officer | Sep 29, 2015 | Option Exercise | $10.03 | 18,582 | 186,377 | 48,492 | Sep 30, 2015, 05:14 PM |
| GUYER DAVID R | Chief Executive Officer | Sep 29, 2015 | Sale | $37.69 | 18,582 | 700,438 | 42,577 | Sep 30, 2015, 05:14 PM |
| PATEL SAMIR CHANDRAKANT | President | Sep 21, 2015 | Option Exercise | $7.60 | 27,215 | 206,751 | 286,507 | Sep 23, 2015, 05:35 PM |
| PATEL SAMIR CHANDRAKANT | President | Sep 21, 2015 | Sale | $46.34 | 27,215 | 1,261,208 | 274,906 | Sep 23, 2015, 05:35 PM |
| GUYER DAVID R | Chief Executive Officer | Aug 31, 2015 | Option Exercise | $10.03 | 18,582 | 186,377 | 48,492 | Sep 02, 2015, 05:33 PM |
| GUYER DAVID R | Chief Executive Officer | Aug 31, 2015 | Sale | $44.88 | 18,582 | 834,050 | 38,408 | Sep 02, 2015, 05:33 PM |
| PATEL SAMIR CHANDRAKANT | President | Aug 20, 2015 | Option Exercise | $1.65 | 27,215 | 44,959 | 286,507 | Aug 24, 2015, 05:06 PM |
| PATEL SAMIR CHANDRAKANT | President | Aug 20, 2015 | Sale | $48.75 | 27,215 | 1,326,597 | 276,877 | Aug 24, 2015, 05:06 PM |
| GUYER DAVID R | Chief Executive Officer | Aug 07, 2015 | Option Exercise | $10.03 | 29,910 | 299,997 | 29,910 | Aug 11, 2015, 05:05 PM |
| GUYER DAVID R | Chief Executive Officer | Jul 30, 2015 | Option Exercise | $10.03 | 18,582 | 186,377 | 18,582 | Aug 03, 2015, 06:57 PM |
| GUYER DAVID R | Chief Executive Officer | Jul 30, 2015 | Sale | $66.32 | 18,582 | 1,232,417 | 13,282 | Aug 03, 2015, 06:57 PM |
| PATEL SAMIR CHANDRAKANT | President | Jul 20, 2015 | Option Exercise | $1.65 | 27,215 | 44,959 | 286,507 | Jul 22, 2015, 05:59 PM |
| PATEL SAMIR CHANDRAKANT | President | Jul 20, 2015 | Sale | $67.87 | 27,215 | 1,847,037 | 276,209 | Jul 22, 2015, 05:59 PM |
| SBLENDORIO GLENN | Director | Jul 17, 2015 | Option Exercise | $13.22 | 2,000 | 26,432 | 2,000 | Jul 20, 2015, 05:19 PM |
| SBLENDORIO GLENN | Director | Sep 30, 2013 | Buy | $22.00 | 1,000 | 22,000 | 1,000 | Jul 20, 2015, 05:19 PM |
| SBLENDORIO GLENN | Director | Jul 17, 2015 | Sale | $70.00 | 2,000 | 140,000 | 0 | Jul 20, 2015, 05:19 PM |
| SBLENDORIO GLENN | Director | Jul 16, 2015 | Sale | $62.00 | 1,000 | 62,000 | 0 | Jul 20, 2015, 05:19 PM |
| WOOD BARBARA A | SVP,General Counsel, Secretary | Jul 01, 2015 | Option Exercise | $24.49 | 2,000 | 48,980 | 2,000 | Jul 02, 2015, 05:06 PM |
| WOOD BARBARA A | SVP,General Counsel, Secretary | Jul 01, 2015 | Sale | $51.94 | 2,000 | 103,880 | 0 | Jul 02, 2015, 05:06 PM |
| GUYER DAVID R | Chief Executive Officer | Jun 29, 2015 | Option Exercise | $10.03 | 18,582 | 186,377 | 18,582 | Jul 01, 2015, 05:06 PM |
| GUYER DAVID R | Chief Executive Officer | Jun 29, 2015 | Sale | $51.05 | 18,582 | 948,694 | 8,001 | Jul 01, 2015, 05:06 PM |
| PATEL SAMIR CHANDRAKANT | President | Jun 19, 2015 | Option Exercise | $2.24 | 259,292 | 581,499 | 259,292 | Jun 23, 2015, 05:22 PM |
| PATEL SAMIR CHANDRAKANT | President | Jun 19, 2015 | Option Exercise | $2.24 | 259,292 | 581,499 | 88,904 | Jun 22, 2015, 05:06 PM |
| PATEL SAMIR CHANDRAKANT | President | Jun 18, 2015 | Option Exercise | $1.61 | 12,000 | 19,262 | 9,529 | Jun 22, 2015, 05:06 PM |
| PATEL SAMIR CHANDRAKANT | President | Jun 18, 2015 | Sale | $49.78 | 12,000 | 597,306 | 3,900 | Jun 22, 2015, 05:06 PM |
| GUYER DAVID R | Chief Executive Officer | May 28, 2015 | Option Exercise | $10.03 | 18,582 | 186,377 | 18,582 | Jun 01, 2015, 05:05 PM |
| GUYER DAVID R | Chief Executive Officer | May 28, 2015 | Sale | $48.62 | 18,582 | 903,516 | 16,182 | Jun 01, 2015, 05:05 PM |
| PATEL SAMIR CHANDRAKANT | President | May 18, 2015 | Option Exercise | $1.59 | 12,000 | 19,116 | 12,000 | May 20, 2015, 05:05 PM |
| PATEL SAMIR CHANDRAKANT | President | May 18, 2015 | Sale | $51.96 | 12,000 | 623,498 | 1,300 | May 20, 2015, 05:05 PM |
| WOOD BARBARA A | SVP, General Counsel,Secretary | May 01, 2015 | Option Exercise | $24.49 | 2,000 | 48,980 | 2,000 | May 05, 2015, 05:05 PM |
| WOOD BARBARA A | SVP, General Counsel,Secretary | May 01, 2015 | Sale | $45.88 | 2,000 | 91,760 | 0 | May 05, 2015, 05:05 PM |
| GUYER DAVID R | Chief Executive Officer | Apr 29, 2015 | Option Exercise | $10.03 | 18,582 | 186,377 | 18,582 | Apr 30, 2015, 05:06 PM |
| GUYER DAVID R | Chief Executive Officer | Apr 29, 2015 | Sale | $48.45 | 18,582 | 900,295 | 5,922 | Apr 30, 2015, 05:06 PM |
| PATEL SAMIR CHANDRAKANT | President | Apr 17, 2015 | Option Exercise | $1.59 | 12,000 | 19,116 | 12,000 | Apr 21, 2015, 05:11 PM |
| PATEL SAMIR CHANDRAKANT | President | Apr 17, 2015 | Sale | $50.47 | 12,000 | 605,622 | 700 | Apr 21, 2015, 05:11 PM |
| Bolte Axel | Director | Mar 30, 2015 | Buy | $48.27 | 500 | 24,135 | 2,500 | Apr 01, 2015, 05:54 PM |
| GUYER DAVID R | Chief Executive Officer | Mar 30, 2015 | Option Exercise | $10.03 | 18,582 | 186,377 | 18,582 | Mar 31, 2015, 05:02 PM |
| GUYER DAVID R | Chief Executive Officer | Mar 30, 2015 | Sale | $48.26 | 18,582 | 896,817 | 1,800 | Mar 31, 2015, 05:02 PM |
| Novo A/S | 10% Owner | Mar 25, 2015 | Option Exercise | $0.06 | 13,668 | 806 | 4,910,487 | Mar 26, 2015, 05:03 PM |
| Novo A/S | 10% Owner | Mar 05, 2015 | Sale | $51.75 | 1,005,000 | 52,008,750 | 4,896,819 | Mar 09, 2015, 07:01 PM |
| GUYER DAVID R | Chief Executive Officer | Mar 02, 2015 | Option Exercise | $10.03 | 18,582 | 186,377 | 18,582 | Mar 03, 2015, 05:38 PM |
| GUYER DAVID R | Chief Executive Officer | Mar 02, 2015 | Sale | $53.22 | 18,582 | 988,987 | 4,171 | Mar 03, 2015, 05:38 PM |
| WOOD BARBARA A | SVP, General Counsel,Secretary | Mar 02, 2015 | Option Exercise | $24.49 | 2,000 | 48,980 | 2,000 | Mar 02, 2015, 05:37 PM |
| WOOD BARBARA A | SVP, General Counsel,Secretary | Mar 02, 2015 | Sale | $53.26 | 2,000 | 106,512 | 100 | Mar 02, 2015, 05:37 PM |
| GUYER DAVID R | Chief Executive Officer | Feb 02, 2015 | Option Exercise | $10.03 | 15,018 | 150,631 | 15,018 | Feb 04, 2015, 05:17 PM |
| GUYER DAVID R | Chief Executive Officer | Feb 02, 2015 | Sale | $53.20 | 15,018 | 798,900 | 10,300 | Feb 04, 2015, 05:17 PM |
| GUYER DAVID R | Chief Executive Officer | Jan 02, 2015 | Option Exercise | $10.03 | 15,034 | 150,791 | 15,034 | Jan 06, 2015, 06:09 PM |
| GUYER DAVID R | Chief Executive Officer | Jan 02, 2015 | Sale | $45.34 | 15,034 | 681,696 | 8,466 | Jan 06, 2015, 06:09 PM |
| GUYER DAVID R | Chief Executive Officer | Dec 01, 2014 | Option Exercise | $10.03 | 15,034 | 150,791 | 15,034 | Dec 03, 2014, 04:28 PM |
| GUYER DAVID R | Chief Executive Officer | Dec 01, 2014 | Sale | $41.58 | 15,034 | 625,047 | 4,800 | Dec 03, 2014, 04:28 PM |
| GUYER DAVID R | Chief Executive Officer | Nov 03, 2014 | Option Exercise | $10.03 | 15,034 | 150,791 | 15,034 | Nov 04, 2014, 04:20 PM |
| GUYER DAVID R | Chief Executive Officer | Nov 03, 2014 | Sale | $39.71 | 15,034 | 596,988 | 2,200 | Nov 04, 2014, 04:20 PM |
| GUYER DAVID R | Chief Executive Officer | Oct 02, 2014 | Option Exercise | $10.03 | 2,807 | 28,154 | 2,807 | Oct 03, 2014, 04:05 PM |
| GUYER DAVID R | Chief Executive Officer | Oct 01, 2014 | Option Exercise | $10.03 | 12,277 | 123,138 | 12,277 | Oct 03, 2014, 04:05 PM |
| GUYER DAVID R | Chief Executive Officer | Oct 02, 2014 | Sale | $38.52 | 2,807 | 108,126 | 0 | Oct 03, 2014, 04:05 PM |
| GUYER DAVID R | Chief Executive Officer | Oct 01, 2014 | Sale | $37.30 | 12,227 | 456,076 | 3,872 | Oct 03, 2014, 04:05 PM |
| PATEL SAMIR CHANDRAKANT | President | Oct 02, 2014 | Sale | $38.04 | 1,965 | 74,749 | 0 | Oct 03, 2014, 04:04 PM |
| PATEL SAMIR CHANDRAKANT | President | Oct 01, 2014 | Sale | $37.28 | 17,676 | 659,003 | 6,212 | Oct 03, 2014, 04:04 PM |
| GUYER DAVID R | Chief Executive Officer | Sep 04, 2014 | Option Exercise | $10.03 | 1,107 | 11,103 | 1,107 | Sep 08, 2014, 05:05 PM |
| GUYER DAVID R | Chief Executive Officer | Sep 04, 2014 | Sale | $38.58 | 1,107 | 42,708 | 0 | Sep 08, 2014, 05:05 PM |
| PATEL SAMIR CHANDRAKANT | President | Sep 02, 2014 | Sale | $37.68 | 18,986 | 715,479 | 21,781 | Sep 04, 2014, 08:04 PM |
| PEACOCK BRUCE | CFO & CBO | Sep 02, 2014 | Option Exercise | $1.65 | 6,191 | 10,228 | 6,191 | Sep 04, 2014, 08:04 PM |
| PEACOCK BRUCE | CFO & CBO | Sep 02, 2014 | Sale | $37.74 | 6,191 | 233,631 | 900 | Sep 04, 2014, 08:04 PM |
| GUYER DAVID R | Chief Executive Officer | Sep 02, 2014 | Option Exercise | $10.03 | 12,727 | 127,652 | 12,727 | Sep 04, 2014, 08:03 PM |
| GUYER DAVID R | Chief Executive Officer | Sep 02, 2014 | Sale | $37.68 | 12,727 | 479,586 | 1,718 | Sep 04, 2014, 08:03 PM |
| PATEL SAMIR CHANDRAKANT | President | Aug 01, 2014 | Sale | $37.80 | 18,986 | 717,643 | 39,027 | Aug 04, 2014, 06:39 PM |
| GUYER DAVID R | Chief Executive Officer | Aug 01, 2014 | Option Exercise | $10.03 | 13,136 | 131,754 | 13,136 | Aug 04, 2014, 06:39 PM |
| GUYER DAVID R | Chief Executive Officer | Aug 01, 2014 | Sale | $37.85 | 13,136 | 497,197 | 800 | Aug 04, 2014, 06:39 PM |
| PEACOCK BRUCE | CFO & CBO | Aug 01, 2014 | Option Exercise | $1.65 | 6,191 | 10,228 | 6,191 | Aug 04, 2014, 06:38 PM |
| PEACOCK BRUCE | CFO & CBO | Aug 01, 2014 | Sale | $37.78 | 6,191 | 233,912 | 100 | Aug 04, 2014, 06:38 PM |
| PATEL SAMIR CHANDRAKANT | President | Jul 01, 2014 | Sale | $41.08 | 18,986 | 779,860 | 62,505 | Jul 03, 2014, 04:10 PM |
| PEACOCK BRUCE | CFO & CBO | Jul 01, 2014 | Option Exercise | $1.65 | 7,739 | 12,785 | 7,739 | Jul 03, 2014, 04:10 PM |
| PEACOCK BRUCE | CFO & CBO | Jul 01, 2014 | Sale | $41.07 | 7,739 | 317,832 | 2,002 | Jul 03, 2014, 04:10 PM |
| GUYER DAVID R | Chief Executive Officer | Jul 01, 2014 | Option Exercise | $10.03 | 15,034 | 150,791 | 15,034 | Jul 03, 2014, 04:09 PM |
| GUYER DAVID R | Chief Executive Officer | Jul 01, 2014 | Sale | $41.08 | 15,034 | 617,559 | 3,482 | Jul 03, 2014, 04:09 PM |
| GALAKATOS NICHOLAS | Director | Jun 16, 2014 | Option Exercise | $44.24 | 5,385 | 238,227 | 7,885 | Jun 18, 2014, 04:33 PM |
| GALAKATOS NICHOLAS | Director | Jun 16, 2014 | Option Exercise | $44.24 | 1,146,152 | 50,704,617 | 1,554,744 | Jun 18, 2014, 04:33 PM |
| GALAKATOS NICHOLAS | Director | Jun 12, 2014 | Sale | $44.51 | 47,217 | 2,101,657 | 2,796,347 | Jun 16, 2014, 07:10 PM |
| GALAKATOS NICHOLAS | Director | Jun 16, 2014 | Sale | $44.00 | 15,482 | 681,208 | 2,698,588 | Jun 16, 2014, 07:10 PM |
| GALAKATOS NICHOLAS | Director | Jun 13, 2014 | Sale | $44.01 | 82,277 | 3,621,225 | 2,714,070 | Jun 16, 2014, 07:10 PM |
| Clarus Lifesciences II, L.P. | 10% Owner | Jun 11, 2014 | Sale | $44.32 | 500 | 22,160 | 4,500 | Jun 11, 2014, 07:45 PM |
| Clarus Lifesciences II, L.P. | 10% Owner | Jun 11, 2014 | Sale | $44.53 | 29,217 | 1,301,074 | 2,843,564 | Jun 11, 2014, 07:45 PM |
| Clarus Lifesciences II, L.P. | 10% Owner | Jun 10, 2014 | Sale | $45.05 | 116,904 | 5,266,977 | 2,909,861 | Jun 11, 2014, 07:45 PM |
| Clarus Lifesciences II, L.P. | 10% Owner | Jun 09, 2014 | Sale | $46.48 | 65,059 | 3,023,963 | 3,029,047 | Jun 11, 2014, 07:45 PM |
| SVLSF IV, LLC | 10% Owner | Jun 04, 2014 | Sale | $42.54 | 1,311,290 | 55,782,278 | 3,054,458 | Jun 05, 2014, 04:29 PM |
| SVLSF IV, LLC | 10% Owner | Jun 04, 2014 | Sale | $42.54 | 655,645 | 27,891,139 | 2,970,133 | Jun 05, 2014, 04:29 PM |
| PEACOCK BRUCE | CFO & CBO | Jun 02, 2014 | Option Exercise | $1.65 | 8,837 | 14,599 | 8,837 | Jun 04, 2014, 05:16 PM |
| PEACOCK BRUCE | CFO & CBO | Jun 03, 2014 | Option Exercise | $1.65 | 5,094 | 8,415 | 5,094 | Jun 04, 2014, 05:16 PM |
| PEACOCK BRUCE | CFO & CBO | Jun 03, 2014 | Sale | $40.41 | 5,094 | 205,849 | 0 | Jun 04, 2014, 05:16 PM |
| PEACOCK BRUCE | CFO & CBO | Jun 02, 2014 | Sale | $39.95 | 8,837 | 353,064 | 700 | Jun 04, 2014, 05:16 PM |
| PATEL SAMIR CHANDRAKANT | President | Jun 02, 2014 | Sale | $39.91 | 27,873 | 1,112,358 | 77,499 | Jun 04, 2014, 05:15 PM |
| GUYER DAVID R | Chief Executive Officer | Jun 02, 2014 | Option Exercise | $10.03 | 13,526 | 135,666 | 25,417 | Jun 04, 2014, 05:14 PM |
| GUYER DAVID R | Chief Executive Officer | Jun 02, 2014 | Sale | $39.92 | 25,417 | 1,014,551 | 950 | Jun 04, 2014, 05:14 PM |
| SVLSF IV, LLC | 10% Owner | Jun 02, 2014 | Sale | $39.91 | 227,900 | 9,095,489 | 4,218,026 | Jun 04, 2014, 04:07 PM |
| SVLSF IV, LLC | 10% Owner | Jun 03, 2014 | Sale | $40.81 | 507,923 | 20,728,338 | 3,607,678 | Jun 04, 2014, 04:07 PM |
| SVLSF IV, LLC | 10% Owner | Jun 03, 2014 | Sale | $40.81 | 1,015,846 | 41,456,677 | 3,710,103 | Jun 04, 2014, 04:07 PM |
| SVLSF IV, LLC | 10% Owner | Jun 02, 2014 | Sale | $39.91 | 113,950 | 4,547,744 | 4,101,579 | Jun 04, 2014, 04:07 PM |
| SVLSF IV, LLC | 10% Owner | May 30, 2014 | Sale | $41.01 | 71,836 | 2,945,994 | 4,212,383 | Jun 02, 2014, 04:09 PM |
| SVLSF IV, LLC | 10% Owner | May 30, 2014 | Sale | $41.01 | 143,672 | 5,891,988 | 4,331,976 | Jun 02, 2014, 04:09 PM |
| SVLSF IV, LLC | 10% Owner | May 29, 2014 | Sale | $40.99 | 238,787 | 9,787,880 | 4,282,236 | Jun 02, 2014, 04:09 PM |
| SVLSF IV, LLC | 10% Owner | May 29, 2014 | Sale | $40.99 | 477,574 | 19,575,759 | 4,403,812 | Jun 02, 2014, 04:09 PM |
| SVLSF IV, LLC | 10% Owner | May 27, 2014 | Sale | $39.87 | 97,737 | 3,896,774 | 4,737,082 | May 29, 2014, 04:00 PM |
| SVLSF IV, LLC | 10% Owner | May 27, 2014 | Sale | $39.87 | 195,474 | 7,793,548 | 4,871,571 | May 29, 2014, 04:00 PM |
| SVLSF IV, LLC | 10% Owner | May 28, 2014 | Sale | $40.33 | 228,972 | 9,234,441 | 4,514,431 | May 29, 2014, 04:00 PM |
| SVLSF IV, LLC | 10% Owner | May 28, 2014 | Sale | $40.33 | 457,944 | 18,468,882 | 4,642,599 | May 29, 2014, 04:00 PM |
| SVLSF IV, LLC | 10% Owner | May 23, 2014 | Sale | $38.34 | 76,150 | 2,919,591 | 4,832,121 | May 27, 2014, 04:20 PM |
| SVLSF IV, LLC | 10% Owner | May 23, 2014 | Sale | $38.34 | 152,300 | 5,839,182 | 4,969,308 | May 27, 2014, 04:20 PM |
| SVLSF IV, LLC | 10% Owner | May 22, 2014 | Sale | $37.57 | 34,000 | 1,277,380 | 4,906,169 | May 27, 2014, 04:20 PM |
| SVLSF IV, LLC | 10% Owner | May 22, 2014 | Sale | $37.57 | 68,000 | 2,554,760 | 5,045,458 | May 27, 2014, 04:20 PM |
| HBM Healthcare Investments (Cayman) Ltd. | 10% Owner | May 13, 2014 | Sale | $29.75 | 500,000 | 14,875,000 | 3,139,902 | May 15, 2014, 05:10 PM |
| GUYER DAVID R | Chief Executive Officer | May 01, 2014 | Sale | $33.71 | 10,665 | 359,508 | 18,529 | May 05, 2014, 09:17 PM |
| PATEL SAMIR CHANDRAKANT | President | May 01, 2014 | Sale | $32.45 | 28,638 | 929,196 | 108,968 | May 05, 2014, 09:16 PM |
| PEACOCK BRUCE | CFO & CBO | May 01, 2014 | Option Exercise | $1.65 | 9,286 | 15,340 | 4,643 | May 05, 2014, 09:16 PM |
| PEACOCK BRUCE | CFO & CBO | May 01, 2014 | Sale | $32.43 | 9,286 | 301,144 | 2,642 | May 05, 2014, 09:16 PM |
| PATEL SAMIR CHANDRAKANT | President | Apr 01, 2014 | Sale | $34.27 | 16,876 | 578,376 | 124,991 | Apr 03, 2014, 04:32 PM |
| PEACOCK BRUCE | CFO & CBO | Apr 01, 2014 | Option Exercise | $1.65 | 6,191 | 10,228 | 6,191 | Apr 03, 2014, 04:31 PM |
| PEACOCK BRUCE | CFO & CBO | Apr 01, 2014 | Sale | $34.26 | 6,191 | 212,099 | 2,267 | Apr 03, 2014, 04:31 PM |
| GUYER DAVID R | Chief Executive Officer | Apr 01, 2014 | Sale | $34.27 | 12,027 | 412,221 | 26,737 | Apr 03, 2014, 04:31 PM |
| PEACOCK BRUCE | CFO & CBO | Mar 24, 2014 | Option Exercise | $1.65 | 6,191 | 10,228 | 6,191 | Mar 26, 2014, 05:29 PM |
| PEACOCK BRUCE | CFO & CBO | Mar 24, 2014 | Sale | $34.77 | 6,137 | 213,369 | 1,106 | Mar 26, 2014, 05:29 PM |
| PATEL SAMIR CHANDRAKANT | President | Mar 24, 2014 | Sale | $34.54 | 16,876 | 582,915 | 139,959 | Mar 26, 2014, 05:26 PM |
| GUYER DAVID R | Chief Executive Officer | Mar 24, 2014 | Sale | $34.53 | 12,027 | 415,316 | 38,276 | Mar 26, 2014, 05:26 PM |
| SVLSF IV, LLC | 10% Owner | Feb 18, 2014 | Sale | $29.61 | 703,788 | 20,839,163 | 4,939,230 | Feb 19, 2014, 04:05 PM |
| SVLSF IV, LLC | 10% Owner | Feb 18, 2014 | Sale | $29.61 | 1,407,576 | 41,678,326 | 5,079,458 | Feb 19, 2014, 04:05 PM |
| GALAKATOS NICHOLAS | Director | Sep 30, 2013 | Buy | $22.00 | 2,500 | 55,000 | 2,500 | Nov 20, 2013, 12:54 PM |
| GALAKATOS NICHOLAS | Director | Sep 30, 2013 | Buy | $22.00 | 2,500 | 55,000 | 2,500 | Nov 20, 2013, 12:54 PM |
| Bolte Axel | Director | Sep 25, 2013 | Buy | $22.00 | 2,000 | 44,000 | 2,000 | Oct 07, 2013, 08:53 PM |
| HBM Healthcare Investments (Cayman) Ltd. | 10% Owner | Sep 30, 2013 | Buy | $22.00 | 228,000 | 5,016,000 | 3,639,902 | Oct 03, 2013, 05:51 PM |
| Novo A/S | 10% Owner | Sep 30, 2013 | Buy | $22.00 | 455,000 | 10,010,000 | 6,896,819 | Oct 02, 2013, 08:15 PM |
| Dyrberg Thomas | Director | Sep 30, 2013 | Buy | $22.00 | 700 | 15,400 | 700 | Oct 02, 2013, 08:13 PM |
Load More Insider Transactions
Buy
Sale
Option Exercise
| Owner | Relationship | Date | Value($) |
| Westby Keith | SVP, Chief Operating Officer | 07/03/2023 | 58,800 |
| Westby Keith | SVP, Chief Operating Officer | 07/03/2023 | 789,000 |
| SBLENDORIO GLENN | Chief Executive Officer | 06/22/2023 | 146,486 |
| Westby Keith | SVP, Chief Operating Officer | 06/02/2023 | 58,800 |
| Westby Keith | SVP, Chief Operating Officer | 06/02/2023 | 757,400 |
| Westby Keith | SVP, Chief Operating Officer | 05/02/2023 | 58,800 |
| Westby Keith | SVP, Chief Operating Officer | 05/01/2023 | 98,250 |
| Westby Keith | SVP, Chief Operating Officer | 05/02/2023 | 756,200 |
| Westby Keith | SVP, Chief Operating Officer | 05/01/2023 | 742,400 |
| Carroll David Francis | SVP, Chief Financial Officer | 05/01/2023 | 178,435 |
| Carroll David Francis | SVP, Chief Financial Officer | 05/01/2023 | 2,352,040 |
| Carroll David Francis | SVP, Chief Financial Officer | 04/24/2023 | 69,848 |
| Carroll David Francis | SVP, Chief Financial Officer | 04/21/2023 | 2,652 |
| Carroll David Francis | SVP, Chief Financial Officer | 04/24/2023 | 1,455,246 |
| Carroll David Francis | SVP, Chief Financial Officer | 04/21/2023 | 54,870 |
| Westby Keith | SVP, Chief Operating Officer | 04/21/2023 | 5,505 |
| Westby Keith | SVP, Chief Operating Officer | 04/24/2023 | 84,895 |
| Westby Keith | SVP, Chief Operating Officer | 04/21/2023 | 36,540 |
| Westby Keith | SVP, Chief Operating Officer | 04/24/2023 | 564,775 |
| Westby Keith | SVP, Chief Operating Officer | 04/03/2023 | 128,659 |
| Westby Keith | SVP, Chief Operating Officer | 04/03/2023 | 1,068,194 |
| Westby Keith | SVP, Chief Operating Officer | 03/02/2023 | 19,282 |
| Westby Keith | SVP, Chief Operating Officer | 03/02/2023 | 478,614 |
| Westby Keith | SVP, Chief Operating Officer | 02/17/2023 | 61,818 |
| Westby Keith | SVP, Chief Operating Officer | 02/17/2023 | 375,750 |
| Westby Keith | SVP, Chief Operating Officer | 02/02/2023 | 476,400 |
| Westby Keith | SVP, Chief Operating Officer | 02/01/2023 | 460,600 |
| Westby Keith | SVP, Chief Operating Officer | 01/03/2023 | 69,809 |
| SBLENDORIO GLENN | Chief Executive Officer | 01/03/2023 | 349,987 |
| Carroll David Francis | SVP, Chief Financial Officer | 01/03/2023 | 72,256 |
| Simms Christopher Paul | SVP, Chief Commercial Officer | 01/03/2023 | 47,502 |
| SBLENDORIO GLENN | CEO | 12/19/2022 | 418,520 |
| Westby Keith | SVP & COO | 12/19/2022 | 144,977 |
| Carroll David Francis | CFO | 12/19/2022 | 121,983 |
| Westby Keith | SVP & COO | 12/13/2022 | 146,482 |
| Westby Keith | SVP & COO | 12/12/2022 | 112,662 |
| Carroll David Francis | CFO | 12/12/2022 | 82,434 |
| Carroll David Francis | CFO | 12/13/2022 | 107,172 |
| Westby Keith | SVP & COO | 12/02/2022 | 52,146 |
| Westby Keith | SVP & COO | 12/01/2022 | 230,289 |
| Dugel Pravin | President | 11/17/2022 | 84,994 |
| SBLENDORIO GLENN | CEO | 11/02/2022 | 1,150,500 |
| Westby Keith | SVP & COO | 11/01/2022 | 62,228 |
| Westby Keith | SVP & COO | 11/01/2022 | 1,744,151 |
| Simms Christopher Paul | SVP, Chief Commercial Officer | 08/03/2022 | 138,060 |
| Gibney Anthony S | EVP, Chief Business Officer | 07/05/2022 | 73,313 |
| Roberts Calvin W. | Director | 06/13/2022 | 240,500 |
| Westby Keith | SVP & COO | 04/18/2022 | 166,300 |
| Westby Keith | SVP & COO | 04/04/2022 | 30,018 |
| Westby Keith | SVP & COO | 04/05/2022 | 13,482 |
| Westby Keith | SVP & COO | 04/04/2022 | 393,346 |
| Westby Keith | SVP & COO | 04/05/2022 | 176,808 |
| SBLENDORIO GLENN | CEO | 04/04/2022 | 937,805 |
| Carroll David Francis | CFO | 04/04/2022 | 29,458 |
| Carroll David Francis | CFO | 04/05/2022 | 6,792 |
| Carroll David Francis | CFO | 04/01/2022 | 36,448 |
| Carroll David Francis | CFO | 04/05/2022 | 89,043 |
| Carroll David Francis | CFO | 04/04/2022 | 757,311 |
| SBLENDORIO GLENN | CEO | 03/30/2022 | 3,566 |
| SBLENDORIO GLENN | CEO | 04/01/2022 | 119,823 |
| SBLENDORIO GLENN | CEO | 03/31/2022 | 4,116 |
| SBLENDORIO GLENN | CEO | 04/01/2022 | 713,230 |
| SBLENDORIO GLENN | CEO | 03/31/2022 | 23,828 |
| SBLENDORIO GLENN | CEO | 03/30/2022 | 20,626 |
| Carroll David Francis | CFO | 03/25/2022 | 24,306 |
| Carroll David Francis | CFO | 03/25/2022 | 285,387 |
| SBLENDORIO GLENN | CEO | 03/25/2022 | 55,199 |
| SBLENDORIO GLENN | CEO | 03/25/2022 | 320,301 |
| Carroll David Francis | CFO | 03/18/2022 | 11,944 |
| Carroll David Francis | CFO | 03/18/2022 | 196,562 |
| SBLENDORIO GLENN | CEO | 03/18/2022 | 10,228 |
| SBLENDORIO GLENN | CEO | 03/18/2022 | 59,145 |
| Westby Keith | SVP & COO | 03/17/2022 | 32,280 |
| Westby Keith | SVP & COO | 03/16/2022 | 117,911 |
| Westby Keith | SVP & COO | 03/01/2022 | 16,799 |
| Westby Keith | SVP & COO | 02/15/2022 | 151,634 |
| Westby Keith | SVP & COO | 02/07/2022 | 150,033 |
| Westby Keith | SVP & COO | 01/03/2022 | 201,265 |
| Carroll David Francis | SVP, CFO and Treasurer | 01/03/2022 | 259,310 |
| SBLENDORIO GLENN | CEO | 12/30/2021 | 294 |
| SBLENDORIO GLENN | CEO | 12/31/2021 | 2,355 |
| SBLENDORIO GLENN | CEO | 12/31/2021 | 13,621 |
| SBLENDORIO GLENN | CEO | 12/30/2021 | 1,701 |
| SBLENDORIO GLENN | CEO | 12/22/2021 | 32,136 |
| SBLENDORIO GLENN | CEO | 12/27/2021 | 7,582 |
| SBLENDORIO GLENN | CEO | 12/23/2021 | 57,701 |
| SBLENDORIO GLENN | CEO | 12/27/2021 | 86,990 |
| SBLENDORIO GLENN | CEO | 12/23/2021 | 527,135 |
| SBLENDORIO GLENN | CEO | 12/22/2021 | 365,783 |
| Westby Keith | SVP & COO | 12/21/2021 | 317,744 |
| Carroll David Francis | SVP, CFO and Treasurer | 12/21/2021 | 898,334 |
| Westby Keith | SVP & COO | 12/20/2021 | 69,743 |
| Carroll David Francis | SVP, CFO and Treasurer | 12/20/2021 | 103,626 |
| SBLENDORIO GLENN | CEO | 12/20/2021 | 286,075 |
| Westby Keith | SVP & COO | 12/13/2021 | 66,603 |
| Carroll David Francis | SVP, CFO and Treasurer | 12/13/2021 | 86,051 |
| SBLENDORIO GLENN | Chief Executive Officer | 12/13/2021 | 122,279 |
| Westby Keith | SVP & COO | 12/10/2021 | 52,517 |
| Carroll David Francis | SVP, CFO and Treasurer | 12/10/2021 | 52,517 |
| Simms Christopher Paul | SVP, Chief Commercial Officer | 11/18/2021 | 50,025 |
| Dugel Pravin | President | 11/11/2021 | 7,000 |
| Dugel Pravin | EVP, Chief Strategy & Business | 04/05/2021 | 179,428 |
| Westby Keith | SVP & COO | 01/04/2021 | 81,344 |
| Carroll David Francis | SVP, CFO and Treasurer | 01/04/2021 | 81,344 |
| Westby Keith | SVP & COO | 12/14/2020 | 32,413 |
| GUYER DAVID R | Executive Chairman | 12/14/2020 | 66,373 |
| Westby Keith | SVP & COO | 12/10/2020 | 25,585 |
| GUYER DAVID R | Executive Chairman | 12/10/2020 | 66,830 |
| Westby Keith | SVP & COO | 01/06/2020 | 2,365 |
| GUYER DAVID R | Executive Chairman | 01/06/2020 | 27,172 |
| GUYER DAVID R | Executive Chairman | 12/13/2019 | 61,215 |
| Westby Keith | SVP & COO | 12/13/2019 | 29,898 |
| SBLENDORIO GLENN | President and CEO | 12/10/2019 | 250,000 |
| SBLENDORIO GLENN | President and CEO | 11/15/2019 | 46,851 |
| Carroll David Francis | SVP, CFO and Treasurer | 07/02/2019 | 3,466 |
| SBLENDORIO GLENN | President and CEO | 05/10/2019 | 37,000 |
| SBLENDORIO GLENN | President and CEO | 04/02/2019 | 9,887 |
| Versant Venture Capital IV, L.P. | 10% Owner | 01/14/2019 | 300,001 |
| Westby Keith | SVP & COO | 01/07/2019 | 389 |
| GUYER DAVID R | Executive Chairman | 01/07/2019 | 5,017 |
| Westby Keith | SVP & COO | 01/03/2019 | 424 |
| GUYER DAVID R | Executive Chairman | 01/03/2019 | 4,510 |
| Carroll David Francis | SVP, CFO and Treasurer | 07/02/2018 | 7,332 |
| SBLENDORIO GLENN | President and CEO | 04/02/2018 | 18,394 |
| WOOD BARBARA A | SVP, Gen. Counsel, Secretary | 01/05/2018 | 1,908 |
| Westby Keith | SVP & COO | 01/05/2018 | 1,005 |
| GUYER DAVID R | Executive Chairman | 01/05/2018 | 12,040 |
| GUYER DAVID R | Executive Chairman | 01/03/2018 | 11,392 |
| WOOD BARBARA A | SVP, General Counsel,Secretary | 01/03/2018 | 2,249 |
| Westby Keith | SVP & COO | 01/03/2018 | 1,153 |
| GUYER DAVID R | Executive Chairman | 01/02/2018 | 52,699 |
| WOOD BARBARA A | SVP,General Counsel,Secretary | 01/02/2018 | 16,872 |
| SBLENDORIO GLENN | President and CEO | 01/02/2018 | 25,804 |
| Carroll David Francis | SVP, CFO and Treasurer | 07/05/2017 | 8,473 |
| GUYER DAVID R | Executive Chairman | 07/05/2017 | 45,609 |
| WOOD BARBARA A | SVP,General Counsel,Secretary | 07/05/2017 | 13,207 |
| SBLENDORIO GLENN | President and CEO | 07/05/2017 | 20,196 |
| Redlick David E | Director | 06/13/2017 | 1,764 |
| SBLENDORIO GLENN | President, CFO and Treasurer | 04/03/2017 | 26,301 |
| Bolte Axel | Director | 12/30/2016 | 28,980 |
| WOOD BARBARA A | SVP,General Counsel,Secretary | 01/05/2017 | 2,921 |
| GUYER DAVID R | Chief Executive Officer | 01/05/2017 | 18,774 |
| PATEL SAMIR CHANDRAKANT | President | 01/05/2017 | 19,066 |
| Bjarke Henric Bjorn | SVP & CCO | 01/05/2017 | 1,567 |
| PATEL SAMIR CHANDRAKANT | President | 01/03/2017 | 14,695 |
| GUYER DAVID R | Chief Executive Officer | 01/03/2017 | 17,072 |
| WOOD BARBARA A | SVP, General Counsel,Secretary | 01/03/2017 | 3,308 |
| WOOD BARBARA A | SVP,General Counsel,Secretary | 12/23/2016 | 3,670 |
| SBLENDORIO GLENN | EVP, COO & CFO, Treasurer | 12/22/2016 | 5,236 |
| Novo A/S | 10% Owner | 12/15/2016 | 6,636,007 |
| Novo A/S | 10% Owner | 12/14/2016 | 10,962,378 |
| GUYER DAVID R | Chief Executive Officer | 11/01/2016 | 221,262 |
| GUYER DAVID R | Chief Executive Officer | 11/01/2016 | 785,638 |
| GUYER DAVID R | Chief Executive Officer | 10/03/2016 | 162,586 |
| GUYER DAVID R | Chief Executive Officer | 10/03/2016 | 978,899 |
| PATEL SAMIR CHANDRAKANT | President | 09/29/2016 | 1,103,345 |
| GUYER DAVID R | Chief Executive Officer | 09/01/2016 | 1,265,075 |
| PATEL SAMIR CHANDRAKANT | President | 08/29/2016 | 1,056,000 |
| GUYER DAVID R | Chief Executive Officer | 08/01/2016 | 241,322 |
| GUYER DAVID R | Chief Executive Officer | 08/01/2016 | 1,551,103 |
| PATEL SAMIR CHANDRAKANT | President | 07/29/2016 | 1,284,185 |
| GUYER DAVID R | Chief Executive Officer | 07/01/2016 | 241,322 |
| GUYER DAVID R | Chief Executive Officer | 07/01/2016 | 1,253,934 |
| PATEL SAMIR CHANDRAKANT | President | 06/30/2016 | 1,115,319 |
| PATEL SAMIR CHANDRAKANT | President | 06/29/2016 | 1,028,321 |
| Bolte Axel | Director | 06/03/2016 | 199,395 |
| GUYER DAVID R | Chief Executive Officer | 06/01/2016 | 301,502 |
| GUYER DAVID R | Chief Executive Officer | 06/01/2016 | 1,584,505 |
| SBLENDORIO GLENN | EVP, COO & CFO, Treasurer | 06/02/2016 | 38,381 |
| PATEL SAMIR CHANDRAKANT | President | 05/31/2016 | 15,661 |
| PATEL SAMIR CHANDRAKANT | President | 05/31/2016 | 1,066,431 |
| Novo A/S | 10% Owner | 05/24/2016 | 63,700,000 |
| GUYER DAVID R | Chief Executive Officer | 05/02/2016 | 221,262 |
| GUYER DAVID R | Chief Executive Officer | 05/02/2016 | 1,018,738 |
| PATEL SAMIR CHANDRAKANT | President | 04/29/2016 | 17,982 |
| PATEL SAMIR CHANDRAKANT | President | 04/29/2016 | 935,875 |
| GUYER DAVID R | Chief Executive Officer | 04/01/2016 | 221,262 |
| GUYER DAVID R | Chief Executive Officer | 04/01/2016 | 972,984 |
| PATEL SAMIR CHANDRAKANT | President | 03/29/2016 | 17,994 |
| PATEL SAMIR CHANDRAKANT | President | 03/29/2016 | 836,909 |
| GUYER DAVID R | Chief Executive Officer | 03/01/2016 | 221,262 |
| GUYER DAVID R | Chief Executive Officer | 03/01/2016 | 1,003,310 |
| PATEL SAMIR CHANDRAKANT | President | 02/29/2016 | 47,777 |
| PATEL SAMIR CHANDRAKANT | President | 02/29/2016 | 902,503 |
| PATEL SAMIR CHANDRAKANT | President | 01/29/2016 | 1,071,740 |
| GUYER DAVID R | Chief Executive Officer | 01/28/2016 | 186,538 |
| GUYER DAVID R | Chief Executive Officer | 01/28/2016 | 997,375 |
| GALAKATOS NICHOLAS | Director | 01/11/2016 | 65,390 |
| GALAKATOS NICHOLAS | Director | 01/11/2016 | 131,781 |
| WOOD BARBARA A | SVP,General Counsel,Secretary | 01/04/2016 | 24,490 |
| WOOD BARBARA A | SVP,General Counsel,Secretary | 01/04/2016 | 76,370 |
| GUYER DAVID R | Chief Executive Officer | 01/04/2016 | 237,140 |
| PATEL SAMIR CHANDRAKANT | President | 01/04/2016 | 186,361 |
| ATIEH MICHAEL G | EVP, CFO, & CBO, Treasurer | 01/04/2016 | 9,430 |
| WOOD BARBARA A | SVP,General Counsel,Secretary | 01/04/2016 | 45,629 |
| GUYER DAVID R | Chief Executive Officer | 12/30/2015 | 186,377 |
| GUYER DAVID R | Chief Executive Officer | 12/30/2015 | 1,464,666 |
| SBLENDORIO GLENN | Director | 12/30/2015 | 26,432 |
| SBLENDORIO GLENN | Director | 12/30/2015 | 160,000 |
| PATEL SAMIR CHANDRAKANT | President | 12/29/2015 | 15,648 |
| PATEL SAMIR CHANDRAKANT | President | 12/29/2015 | 91,761 |
| PATEL SAMIR CHANDRAKANT | President | 12/24/2015 | 543,716 |
| PATEL SAMIR CHANDRAKANT | President | 12/24/2015 | 2,007,101 |
| GALAKATOS NICHOLAS | Director | 12/10/2015 | 128,871 |
| GALAKATOS NICHOLAS | Director | 12/10/2015 | 64,438 |
| WOOD BARBARA A | SVP,General Counsel,Secretary | 12/01/2015 | 48,980 |
| WOOD BARBARA A | SVP,General Counsel,Secretary | 12/01/2015 | 126,482 |
| GUYER DAVID R | Chief Executive Officer | 11/30/2015 | 186,377 |
| GUYER DAVID R | Chief Executive Officer | 11/30/2015 | 1,161,132 |
| PATEL SAMIR CHANDRAKANT | President | 11/24/2015 | 806,152 |
| PATEL SAMIR CHANDRAKANT | President | 11/24/2015 | 1,640,318 |
| GALAKATOS NICHOLAS | Director | 11/18/2015 | 30,000 |
| GALAKATOS NICHOLAS | Director | 11/18/2015 | 60,000 |
| GALAKATOS NICHOLAS | Director | 11/09/2015 | 30,000 |
| GALAKATOS NICHOLAS | Director | 11/09/2015 | 60,000 |
| GALAKATOS NICHOLAS | Director | 11/10/2015 | 29,345 |
| GALAKATOS NICHOLAS | Director | 11/10/2015 | 58,690 |
| PATEL SAMIR CHANDRAKANT | President | 11/05/2015 | 1,107,767 |
| GALAKATOS NICHOLAS | Director | 11/02/2015 | 27,000 |
| GALAKATOS NICHOLAS | Director | 11/02/2015 | 54,000 |
| GUYER DAVID R | Chief Executive Officer | 10/30/2015 | 186,377 |
| GUYER DAVID R | Chief Executive Officer | 10/30/2015 | 926,909 |
| PATEL SAMIR CHANDRAKANT | President | 10/21/2015 | 844,364 |
| PATEL SAMIR CHANDRAKANT | President | 10/21/2015 | 1,177,713 |
| WOOD BARBARA A | SVP,General Counsel,Secretary | 10/16/2015 | 48,980 |
| WOOD BARBARA A | SVP,General Counsel,Secretary | 10/16/2015 | 90,000 |
| GUYER DAVID R | Chief Executive Officer | 09/29/2015 | 186,377 |
| GUYER DAVID R | Chief Executive Officer | 09/29/2015 | 700,438 |
| PATEL SAMIR CHANDRAKANT | President | 09/21/2015 | 206,751 |
| PATEL SAMIR CHANDRAKANT | President | 09/21/2015 | 1,261,208 |
| GUYER DAVID R | Chief Executive Officer | 08/31/2015 | 186,377 |
| GUYER DAVID R | Chief Executive Officer | 08/31/2015 | 834,050 |
| PATEL SAMIR CHANDRAKANT | President | 08/20/2015 | 44,959 |
| PATEL SAMIR CHANDRAKANT | President | 08/20/2015 | 1,326,597 |
| GUYER DAVID R | Chief Executive Officer | 08/07/2015 | 299,997 |
| GUYER DAVID R | Chief Executive Officer | 07/30/2015 | 186,377 |
| GUYER DAVID R | Chief Executive Officer | 07/30/2015 | 1,232,417 |
| PATEL SAMIR CHANDRAKANT | President | 07/20/2015 | 44,959 |
| PATEL SAMIR CHANDRAKANT | President | 07/20/2015 | 1,847,037 |
| SBLENDORIO GLENN | Director | 07/17/2015 | 26,432 |
| SBLENDORIO GLENN | Director | 09/30/2013 | 22,000 |
| SBLENDORIO GLENN | Director | 07/17/2015 | 140,000 |
| SBLENDORIO GLENN | Director | 07/16/2015 | 62,000 |
| WOOD BARBARA A | SVP,General Counsel, Secretary | 07/01/2015 | 48,980 |
| WOOD BARBARA A | SVP,General Counsel, Secretary | 07/01/2015 | 103,880 |
| GUYER DAVID R | Chief Executive Officer | 06/29/2015 | 186,377 |
| GUYER DAVID R | Chief Executive Officer | 06/29/2015 | 948,694 |
| PATEL SAMIR CHANDRAKANT | President | 06/19/2015 | 581,499 |
| PATEL SAMIR CHANDRAKANT | President | 06/19/2015 | 581,499 |
| PATEL SAMIR CHANDRAKANT | President | 06/18/2015 | 19,262 |
| PATEL SAMIR CHANDRAKANT | President | 06/18/2015 | 597,306 |
| GUYER DAVID R | Chief Executive Officer | 05/28/2015 | 186,377 |
| GUYER DAVID R | Chief Executive Officer | 05/28/2015 | 903,516 |
| PATEL SAMIR CHANDRAKANT | President | 05/18/2015 | 19,116 |
| PATEL SAMIR CHANDRAKANT | President | 05/18/2015 | 623,498 |
| WOOD BARBARA A | SVP, General Counsel,Secretary | 05/01/2015 | 48,980 |
| WOOD BARBARA A | SVP, General Counsel,Secretary | 05/01/2015 | 91,760 |
| GUYER DAVID R | Chief Executive Officer | 04/29/2015 | 186,377 |
| GUYER DAVID R | Chief Executive Officer | 04/29/2015 | 900,295 |
| PATEL SAMIR CHANDRAKANT | President | 04/17/2015 | 19,116 |
| PATEL SAMIR CHANDRAKANT | President | 04/17/2015 | 605,622 |
| Bolte Axel | Director | 03/30/2015 | 24,135 |
| GUYER DAVID R | Chief Executive Officer | 03/30/2015 | 186,377 |
| GUYER DAVID R | Chief Executive Officer | 03/30/2015 | 896,817 |
| Novo A/S | 10% Owner | 03/25/2015 | 806 |
| Novo A/S | 10% Owner | 03/05/2015 | 52,008,750 |
| GUYER DAVID R | Chief Executive Officer | 03/02/2015 | 186,377 |
| GUYER DAVID R | Chief Executive Officer | 03/02/2015 | 988,987 |
| WOOD BARBARA A | SVP, General Counsel,Secretary | 03/02/2015 | 48,980 |
| WOOD BARBARA A | SVP, General Counsel,Secretary | 03/02/2015 | 106,512 |
| GUYER DAVID R | Chief Executive Officer | 02/02/2015 | 150,631 |
| GUYER DAVID R | Chief Executive Officer | 02/02/2015 | 798,900 |
| GUYER DAVID R | Chief Executive Officer | 01/02/2015 | 150,791 |
| GUYER DAVID R | Chief Executive Officer | 01/02/2015 | 681,696 |
| GUYER DAVID R | Chief Executive Officer | 12/01/2014 | 150,791 |
| GUYER DAVID R | Chief Executive Officer | 12/01/2014 | 625,047 |
| GUYER DAVID R | Chief Executive Officer | 11/03/2014 | 150,791 |
| GUYER DAVID R | Chief Executive Officer | 11/03/2014 | 596,988 |
| GUYER DAVID R | Chief Executive Officer | 10/02/2014 | 28,154 |
| GUYER DAVID R | Chief Executive Officer | 10/01/2014 | 123,138 |
| GUYER DAVID R | Chief Executive Officer | 10/02/2014 | 108,126 |
| GUYER DAVID R | Chief Executive Officer | 10/01/2014 | 456,076 |
| PATEL SAMIR CHANDRAKANT | President | 10/02/2014 | 74,749 |
| PATEL SAMIR CHANDRAKANT | President | 10/01/2014 | 659,003 |
| GUYER DAVID R | Chief Executive Officer | 09/04/2014 | 11,103 |
| GUYER DAVID R | Chief Executive Officer | 09/04/2014 | 42,708 |
| PATEL SAMIR CHANDRAKANT | President | 09/02/2014 | 715,479 |
| PEACOCK BRUCE | CFO & CBO | 09/02/2014 | 10,228 |
| PEACOCK BRUCE | CFO & CBO | 09/02/2014 | 233,631 |
| GUYER DAVID R | Chief Executive Officer | 09/02/2014 | 127,652 |
| GUYER DAVID R | Chief Executive Officer | 09/02/2014 | 479,586 |
| PATEL SAMIR CHANDRAKANT | President | 08/01/2014 | 717,643 |
| GUYER DAVID R | Chief Executive Officer | 08/01/2014 | 131,754 |
| GUYER DAVID R | Chief Executive Officer | 08/01/2014 | 497,197 |
| PEACOCK BRUCE | CFO & CBO | 08/01/2014 | 10,228 |
| PEACOCK BRUCE | CFO & CBO | 08/01/2014 | 233,912 |
| PATEL SAMIR CHANDRAKANT | President | 07/01/2014 | 779,860 |
| PEACOCK BRUCE | CFO & CBO | 07/01/2014 | 12,785 |
| PEACOCK BRUCE | CFO & CBO | 07/01/2014 | 317,832 |
| GUYER DAVID R | Chief Executive Officer | 07/01/2014 | 150,791 |
| GUYER DAVID R | Chief Executive Officer | 07/01/2014 | 617,559 |
| GALAKATOS NICHOLAS | Director | 06/16/2014 | 238,227 |
| GALAKATOS NICHOLAS | Director | 06/16/2014 | 50,704,617 |
| GALAKATOS NICHOLAS | Director | 06/12/2014 | 2,101,657 |
| GALAKATOS NICHOLAS | Director | 06/16/2014 | 681,208 |
| GALAKATOS NICHOLAS | Director | 06/13/2014 | 3,621,225 |
| Clarus Lifesciences II, L.P. | 10% Owner | 06/11/2014 | 22,160 |
| Clarus Lifesciences II, L.P. | 10% Owner | 06/11/2014 | 1,301,074 |
| Clarus Lifesciences II, L.P. | 10% Owner | 06/10/2014 | 5,266,977 |
| Clarus Lifesciences II, L.P. | 10% Owner | 06/09/2014 | 3,023,963 |
| SVLSF IV, LLC | 10% Owner | 06/04/2014 | 55,782,278 |
| SVLSF IV, LLC | 10% Owner | 06/04/2014 | 27,891,139 |
| PEACOCK BRUCE | CFO & CBO | 06/02/2014 | 14,599 |
| PEACOCK BRUCE | CFO & CBO | 06/03/2014 | 8,415 |
| PEACOCK BRUCE | CFO & CBO | 06/03/2014 | 205,849 |
| PEACOCK BRUCE | CFO & CBO | 06/02/2014 | 353,064 |
| PATEL SAMIR CHANDRAKANT | President | 06/02/2014 | 1,112,358 |
| GUYER DAVID R | Chief Executive Officer | 06/02/2014 | 135,666 |
| GUYER DAVID R | Chief Executive Officer | 06/02/2014 | 1,014,551 |
| SVLSF IV, LLC | 10% Owner | 06/02/2014 | 9,095,489 |
| SVLSF IV, LLC | 10% Owner | 06/03/2014 | 20,728,338 |
| SVLSF IV, LLC | 10% Owner | 06/03/2014 | 41,456,677 |
| SVLSF IV, LLC | 10% Owner | 06/02/2014 | 4,547,744 |
| SVLSF IV, LLC | 10% Owner | 05/30/2014 | 2,945,994 |
| SVLSF IV, LLC | 10% Owner | 05/30/2014 | 5,891,988 |
| SVLSF IV, LLC | 10% Owner | 05/29/2014 | 9,787,880 |
| SVLSF IV, LLC | 10% Owner | 05/29/2014 | 19,575,759 |
| SVLSF IV, LLC | 10% Owner | 05/27/2014 | 3,896,774 |
| SVLSF IV, LLC | 10% Owner | 05/27/2014 | 7,793,548 |
| SVLSF IV, LLC | 10% Owner | 05/28/2014 | 9,234,441 |
| SVLSF IV, LLC | 10% Owner | 05/28/2014 | 18,468,882 |
| SVLSF IV, LLC | 10% Owner | 05/23/2014 | 2,919,591 |
| SVLSF IV, LLC | 10% Owner | 05/23/2014 | 5,839,182 |
| SVLSF IV, LLC | 10% Owner | 05/22/2014 | 1,277,380 |
| SVLSF IV, LLC | 10% Owner | 05/22/2014 | 2,554,760 |
| HBM Healthcare Investments (Cayman) Ltd. | 10% Owner | 05/13/2014 | 14,875,000 |
| GUYER DAVID R | Chief Executive Officer | 05/01/2014 | 359,508 |
| PATEL SAMIR CHANDRAKANT | President | 05/01/2014 | 929,196 |
| PEACOCK BRUCE | CFO & CBO | 05/01/2014 | 15,340 |
| PEACOCK BRUCE | CFO & CBO | 05/01/2014 | 301,144 |
| PATEL SAMIR CHANDRAKANT | President | 04/01/2014 | 578,376 |
| PEACOCK BRUCE | CFO & CBO | 04/01/2014 | 10,228 |
| PEACOCK BRUCE | CFO & CBO | 04/01/2014 | 212,099 |
| GUYER DAVID R | Chief Executive Officer | 04/01/2014 | 412,221 |
| PEACOCK BRUCE | CFO & CBO | 03/24/2014 | 10,228 |
| PEACOCK BRUCE | CFO & CBO | 03/24/2014 | 213,369 |
| PATEL SAMIR CHANDRAKANT | President | 03/24/2014 | 582,915 |
| GUYER DAVID R | Chief Executive Officer | 03/24/2014 | 415,316 |
| SVLSF IV, LLC | 10% Owner | 02/18/2014 | 20,839,163 |
| SVLSF IV, LLC | 10% Owner | 02/18/2014 | 41,678,326 |
| GALAKATOS NICHOLAS | Director | 09/30/2013 | 55,000 |
| GALAKATOS NICHOLAS | Director | 09/30/2013 | 55,000 |
| Bolte Axel | Director | 09/25/2013 | 44,000 |
| HBM Healthcare Investments (Cayman) Ltd. | 10% Owner | 09/30/2013 | 5,016,000 |
| Novo A/S | 10% Owner | 09/30/2013 | 10,010,000 |
| Dyrberg Thomas | Director | 09/30/2013 | 15,400 |
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