Odonate Therapeutics Inc. (ODT) NASDAQ
$1.12 - (-)
Market Cap: -
As of 01/14/22 12:00 AM EST. Market closed.
Odonate Therapeutics Inc. (ODT)
NASDAQ
$1.12
- (-)
Market Cap: -
As of 01/14/22 12:00 AM EST. Market closed.
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Odonate Therapeutics, Inc. is a pharmaceutical company dedicated to the development of best-in-class therapeutics that improve and extend the lives of patients with cancer. Odonate’s initial focus is on the development of tesetaxel, an investigational, orally administered chemotherapy agent that belongs to a class of drugs known as taxanes, which are widely used in the treatment of cancer. ... read more
Odonate Therapeutics, Inc. is a pharmaceutical company dedicated to the development of best-in-class therapeutics that improve and extend the lives of patients with cancer. Odonate’s initial focus is on the development of tesetaxel, an investigational, orally administered chemotherapy agent that belongs to a class of drugs known as taxanes, which are widely used in the treatment of cancer. Odonate’s goal for tesetaxel is to develop an effective chemotherapy choice for patients that provides quality-of-life advantages over current alternatives. read less
COMPANY PROFILE
Sector
Manufacturing
Industry
Medicinal and Botanical Manufacturing
CEO Compensation (Base)
$1
CEO Compensation (Total)
$1
Sector
Manufacturing
Industry
Medicinal and Botanical Manufacturing
CEO Compensation (Base)
$1
CEO Compensation (Total)
$1
URL
Address
4747 Executive Dr, California, San Diego, 92121-3095.
PRICE CHART FOR ODONATE THERAPEUTICS INC
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NEWS
INSIDEARBITRAGE ARTICLES
KEY STATS
Open
$1.16
Previous Close
$1.12
Days Range
$1.11 - $1.20
52 week range
- - -
Volume
0
Avg. Volume (30 days)
0
Market Cap
-
Dividend Yield
-
P/E
-
Shares Outstanding
38,490,336
Open
$1.16
Previous Close
$1.12
Days Range
$1.11 - $1.20
52 week range
- - -
Volume
0
Avg. Volume (30 days)
0
Market Cap
-
Dividend Yield
-
P/E
-
Shares Outstanding
38,490,336
FINANCIAL STATEMENTS FOR ODONATE THERAPEUTICS INC
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INSIDER TRANSACTIONS FOR ODONATE THERAPEUTICS INC
| Owner | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| EcoR1 Capital, LLC | 10% Owner | Dec 01, 2021 | Buy | $1.66 | 185,941 | 308,662 | 5,701,669 | Dec 10, 2021, 06:50 PM |
| EcoR1 Capital, LLC | 10% Owner | Dec 10, 2021 | Sale | $1.65 | 5,545,000 | 9,147,420 | 545,000 | Dec 10, 2021, 06:50 PM |
| EcoR1 Capital, LLC | 10% Owner | Dec 09, 2021 | Sale | $1.82 | 156,669 | 284,981 | 5,545,000 | Dec 10, 2021, 06:50 PM |
| EcoR1 Capital, LLC | 10% Owner | Dec 01, 2021 | Sale | $1.66 | 185,941 | 308,662 | 5,701,669 | Dec 10, 2021, 06:50 PM |
| Boxer Capital, LLC | 10% Owner | Nov 22, 2021 | Sale | $1.55 | 200,000 | 309,660 | 4,407,086 | Nov 24, 2021, 06:00 PM |
| Boxer Capital, LLC | 10% Owner | Nov 24, 2021 | Sale | $1.57 | 200,000 | 313,680 | 4,207,086 | Nov 24, 2021, 06:00 PM |
| Davis Aaron I. | Director | Nov 19, 2021 | Sale | $1.84 | 150,000 | 276,285 | 4,607,086 | Nov 19, 2021, 07:22 PM |
| Davis Aaron I. | Director | Nov 19, 2021 | Sale | $1.92 | 30,000 | 57,495 | 445,756 | Nov 19, 2021, 07:22 PM |
| Davis Aaron I. | Director | Nov 18, 2021 | Sale | $1.95 | 250,000 | 487,250 | 4,757,086 | Nov 19, 2021, 07:22 PM |
| Davis Aaron I. | Director | Nov 17, 2021 | Sale | $2.17 | 600,000 | 1,299,240 | 5,007,086 | Nov 19, 2021, 07:22 PM |
| Davis Aaron I. | Director | Nov 17, 2021 | Sale | $2.23 | 170,000 | 379,678 | 475,756 | Nov 19, 2021, 07:22 PM |
| Boxer Capital, LLC | Director | Nov 19, 2021 | Sale | $1.84 | 150,000 | 276,285 | 4,607,086 | Nov 19, 2021, 07:21 PM |
| Boxer Capital, LLC | Director | Nov 18, 2021 | Sale | $1.95 | 250,000 | 487,250 | 4,757,086 | Nov 19, 2021, 07:21 PM |
| Boxer Capital, LLC | Director | Nov 17, 2021 | Sale | $2.17 | 600,000 | 1,299,240 | 5,007,086 | Nov 19, 2021, 07:21 PM |
| TANG KEVIN C | Chief Executive Officer | Nov 19, 2021 | Sale | $1.92 | 365,289 | 699,930 | 12,767,435 | Nov 19, 2021, 04:38 PM |
| TANG KEVIN C | Chief Executive Officer | Nov 18, 2021 | Sale | $1.90 | 1,094,265 | 2,081,879 | 14,014,566 | Nov 19, 2021, 04:38 PM |
| TANG KEVIN C | Chief Executive Officer | Nov 17, 2021 | Sale | $2.29 | 1,287,577 | 2,948,747 | 15,045,717 | Nov 19, 2021, 04:38 PM |
| Hearne Michael S | Chief Financial Officer | Mar 15, 2021 | Option Exercise | $16.22 | 37 | 600 | 2,620 | Mar 17, 2021, 04:04 PM |
| O'Connell Joseph P | Chief Medical Officer | Mar 15, 2021 | Option Exercise | $16.22 | 99 | 1,606 | 3,610 | Mar 17, 2021, 04:04 PM |
| Hearne Michael S | Chief Financial Officer | Feb 26, 2021 | Option Exercise | $17.89 | 34 | 608 | 2,583 | Mar 02, 2021, 04:03 PM |
| O'Connell Joseph P | Chief Medical Officer | Feb 26, 2021 | Option Exercise | $17.89 | 90 | 1,610 | 3,511 | Mar 02, 2021, 04:02 PM |
| Hearne Michael S | Chief Financial Officer | Feb 12, 2021 | Option Exercise | $21.19 | 28 | 593 | 2,549 | Feb 17, 2021, 04:07 PM |
| O'Connell Joseph P | Chief Medical Officer | Feb 12, 2021 | Option Exercise | $21.19 | 76 | 1,610 | 3,421 | Feb 17, 2021, 04:06 PM |
| Hearne Michael S | Chief Financial Officer | Jan 29, 2021 | Option Exercise | $19.64 | 31 | 609 | 2,521 | Feb 02, 2021, 04:10 PM |
| O'Connell Joseph P | Chief Medical Officer | Jan 29, 2021 | Option Exercise | $19.64 | 82 | 1,610 | 3,345 | Feb 02, 2021, 04:09 PM |
| Hearne Michael S | Chief Financial Officer | Jan 15, 2021 | Option Exercise | $16.99 | 35 | 595 | 2,490 | Jan 20, 2021, 04:01 PM |
| O'Connell Joseph P | Chief Medical Officer | Jan 15, 2021 | Option Exercise | $16.99 | 94 | 1,597 | 3,263 | Jan 20, 2021, 04:01 PM |
| Hearne Michael S | Chief Financial Officer | Dec 31, 2020 | Option Exercise | $16.32 | 350 | 5,712 | 2,455 | Jan 05, 2021, 04:06 PM |
| O'Connell Joseph P | Chief Medical Officer | Dec 31, 2020 | Option Exercise | $16.32 | 169 | 2,758 | 3,169 | Jan 05, 2021, 04:04 PM |
| Johnson Craig A | Director | Dec 29, 2020 | Buy | $17.00 | 3,000 | 51,000 | 3,000 | Dec 31, 2020, 04:01 PM |
| Boxer Capital, LLC | Director | Dec 30, 2020 | Buy | $17.46 | 100,000 | 1,746,380 | 5,607,086 | Dec 30, 2020, 06:19 PM |
| Boxer Capital, LLC | Director | Dec 28, 2020 | Buy | $17.06 | 300,000 | 5,117,048 | 5,507,086 | Dec 30, 2020, 06:19 PM |
| Davis Aaron I. | Director | Dec 29, 2020 | Buy | $17.11 | 225,000 | 3,849,548 | 5,507,086 | Dec 30, 2020, 06:18 PM |
| Davis Aaron I. | Director | Dec 28, 2020 | Buy | $16.90 | 75,000 | 1,267,500 | 5,282,086 | Dec 30, 2020, 06:18 PM |
| Davis Aaron I. | Director | Dec 30, 2020 | Buy | $17.46 | 100,000 | 1,746,380 | 5,607,086 | Dec 30, 2020, 06:18 PM |
| TANG KEVIN C | Chief Executive Officer | Dec 21, 2020 | Buy | $14.58 | 62,144 | 905,767 | 15,300,926 | Dec 23, 2020, 04:41 PM |
| TANG KEVIN C | Chief Executive Officer | Dec 23, 2020 | Buy | $15.58 | 139,138 | 2,167,853 | 15,514,566 | Dec 23, 2020, 04:41 PM |
| TANG KEVIN C | Chief Executive Officer | Dec 22, 2020 | Buy | $14.87 | 74,502 | 1,107,587 | 15,375,428 | Dec 23, 2020, 04:41 PM |
| Hearne Michael S | Chief Financial Officer | Dec 15, 2020 | Option Exercise | $12.91 | 43 | 555 | 2,105 | Dec 17, 2020, 04:01 PM |
| O'Connell Joseph P | Chief Medical Officer | Dec 15, 2020 | Option Exercise | $12.91 | 121 | 1,562 | 3,000 | Dec 17, 2020, 04:01 PM |
| Hearne Michael S | Chief Financial Officer | Nov 30, 2020 | Option Exercise | $12.77 | 45 | 575 | 2,062 | Dec 02, 2020, 04:02 PM |
| O'Connell Joseph P | Chief Medical Officer | Nov 30, 2020 | Option Exercise | $12.77 | 122 | 1,558 | 2,879 | Dec 02, 2020, 04:02 PM |
| Lemkey John G | Chief Operating Officer | Nov 30, 2020 | Option Exercise | $12.77 | 12 | 153 | 3,457 | Dec 02, 2020, 04:01 PM |
| Hearne Michael S | Chief Financial Officer | Nov 13, 2020 | Option Exercise | $12.20 | 46 | 561 | 2,017 | Nov 17, 2020, 04:06 PM |
| O'Connell Joseph P | Chief Medical Officer | Nov 13, 2020 | Option Exercise | $12.20 | 128 | 1,562 | 2,757 | Nov 17, 2020, 04:06 PM |
| Lemkey John G | Chief Operating Officer | Nov 13, 2020 | Option Exercise | $12.20 | 96 | 1,171 | 3,445 | Nov 17, 2020, 04:04 PM |
| Hearne Michael S | Chief Financial Officer | Oct 30, 2020 | Option Exercise | $12.25 | 46 | 564 | 1,971 | Nov 03, 2020, 04:06 PM |
| O'Connell Joseph P | Chief Medical Officer | Oct 30, 2020 | Option Exercise | $12.25 | 127 | 1,556 | 2,629 | Nov 03, 2020, 04:06 PM |
| Lemkey John G | Chief Operating Officer | Oct 30, 2020 | Option Exercise | $12.25 | 96 | 1,176 | 3,349 | Nov 03, 2020, 04:05 PM |
| Hearne Michael S | Chief Financial Officer | Oct 15, 2020 | Option Exercise | $13.35 | 42 | 561 | 1,925 | Oct 19, 2020, 04:04 PM |
| O'Connell Joseph P | Chief Medical Officer | Oct 15, 2020 | Option Exercise | $13.35 | 117 | 1,562 | 2,502 | Oct 19, 2020, 04:01 PM |
| Lemkey John G | Chief Operating Officer | Oct 15, 2020 | Option Exercise | $13.35 | 88 | 1,175 | 3,253 | Oct 19, 2020, 04:01 PM |
| Hearne Michael S | Chief Financial Officer | Sep 30, 2020 | Option Exercise | $11.42 | 50 | 571 | 1,883 | Oct 02, 2020, 04:03 PM |
| O'Connell Joseph P | Chief Medical Officer | Sep 30, 2020 | Option Exercise | $11.42 | 82 | 936 | 2,385 | Oct 02, 2020, 04:02 PM |
| Lemkey John G | Chief Operating Officer | Sep 30, 2020 | Option Exercise | $11.42 | 102 | 1,165 | 3,165 | Oct 02, 2020, 04:02 PM |
| Davis Aaron I. | Director | Sep 29, 2020 | Buy | $14.08 | 122,000 | 1,717,760 | 5,207,086 | Sep 30, 2020, 04:36 PM |
| Davis Aaron I. | Director | Sep 28, 2020 | Buy | $13.03 | 93,200 | 1,214,396 | 5,085,086 | Sep 30, 2020, 04:36 PM |
| Boxer Capital, LLC | Director | Sep 29, 2020 | Buy | $14.08 | 122,000 | 1,717,760 | 5,207,086 | Sep 30, 2020, 04:31 PM |
| Boxer Capital, LLC | Director | Sep 28, 2020 | Buy | $13.03 | 93,200 | 1,214,396 | 5,085,086 | Sep 30, 2020, 04:31 PM |
| TANG KEVIN C | Chief Executive Officer | Sep 29, 2020 | Buy | $13.85 | 10,882 | 150,698 | 15,238,782 | Sep 30, 2020, 04:01 PM |
| TANG KEVIN C | Chief Executive Officer | Sep 28, 2020 | Buy | $13.06 | 100,000 | 1,305,710 | 15,227,900 | Sep 30, 2020, 04:01 PM |
| Hearne Michael S | Chief Financial Officer | Sep 15, 2020 | Option Exercise | $13.06 | 43 | 562 | 1,833 | Sep 17, 2020, 04:13 PM |
| O'Connell Joseph P | Chief Medical Officer | Sep 15, 2020 | Option Exercise | $13.06 | 72 | 940 | 2,303 | Sep 17, 2020, 04:12 PM |
| Lemkey John G | Chief Operating Officer | Sep 15, 2020 | Option Exercise | $13.06 | 90 | 1,175 | 3,063 | Sep 17, 2020, 04:09 PM |
| Davis Aaron I. | Director | Sep 09, 2020 | Buy | $15.20 | 81,100 | 1,232,720 | 4,991,886 | Sep 09, 2020, 05:59 PM |
| Davis Aaron I. | Director | Sep 08, 2020 | Buy | $14.69 | 18,800 | 276,172 | 4,910,786 | Sep 09, 2020, 05:59 PM |
| Davis Aaron I. | Director | Sep 04, 2020 | Buy | $14.89 | 125,100 | 1,862,739 | 4,891,986 | Sep 09, 2020, 05:59 PM |
| Boxer Capital, LLC | Director | Sep 09, 2020 | Buy | $15.20 | 81,100 | 1,232,720 | 4,991,886 | Sep 09, 2020, 05:59 PM |
| Boxer Capital, LLC | Director | Sep 08, 2020 | Buy | $14.69 | 18,800 | 276,172 | 4,910,786 | Sep 09, 2020, 05:59 PM |
| Boxer Capital, LLC | Director | Sep 04, 2020 | Buy | $14.89 | 125,100 | 1,862,739 | 4,891,986 | Sep 09, 2020, 05:59 PM |
| Hearne Michael S | Chief Financial Officer | Aug 31, 2020 | Option Exercise | $13.73 | 42 | 577 | 1,790 | Sep 02, 2020, 04:03 PM |
| O'Connell Joseph P | Chief Medical Officer | Aug 31, 2020 | Option Exercise | $13.73 | 69 | 947 | 2,231 | Sep 02, 2020, 04:02 PM |
| Lemkey John G | Chief Operating Officer | Aug 31, 2020 | Option Exercise | $13.73 | 87 | 1,195 | 2,973 | Sep 02, 2020, 04:00 PM |
| Boxer Capital, LLC | Director | Aug 28, 2020 | Buy | $14.25 | 1,403,509 | 20,000,003 | 4,766,886 | Sep 01, 2020, 04:30 PM |
| Davis Aaron I. | Director | Aug 28, 2020 | Buy | $14.25 | 1,403,509 | 20,000,003 | 4,766,886 | Sep 01, 2020, 04:30 PM |
| TANG KEVIN C | Chief Executive Officer | Aug 28, 2020 | Buy | $14.25 | 1,052,631 | 14,999,992 | 15,127,900 | Sep 01, 2020, 08:17 AM |
| Hearne Michael S | Chief Financial Officer | Aug 14, 2020 | Option Exercise | $30.71 | 18 | 553 | 1,748 | Aug 18, 2020, 04:03 PM |
| O'Connell Joseph P | Chief Medical Officer | Aug 14, 2020 | Option Exercise | $30.71 | 31 | 952 | 2,162 | Aug 18, 2020, 04:03 PM |
| Lemkey John G | Chief Operating Officer | Aug 14, 2020 | Option Exercise | $30.71 | 38 | 1,167 | 2,886 | Aug 18, 2020, 04:02 PM |
| Hearne Michael S | Chief Financial Officer | Jul 31, 2020 | Option Exercise | $30.91 | 18 | 556 | 1,730 | Aug 04, 2020, 04:03 PM |
| O'Connell Joseph P | Chief Medical Officer | Jul 31, 2020 | Option Exercise | $30.91 | 30 | 927 | 2,131 | Aug 04, 2020, 04:02 PM |
| Lemkey John G | Chief Operating Officer | Jul 31, 2020 | Option Exercise | $30.91 | 38 | 1,175 | 2,848 | Aug 04, 2020, 04:01 PM |
| Hearne Michael S | Chief Financial Officer | Jul 15, 2020 | Option Exercise | $34.99 | 17 | 595 | 1,712 | Jul 17, 2020, 04:04 PM |
| O'Connell Joseph P | Chief Medical Officer | Jul 15, 2020 | Option Exercise | $34.99 | 27 | 945 | 2,101 | Jul 17, 2020, 04:03 PM |
| Lemkey John G | Chief Operating Officer | Jul 15, 2020 | Option Exercise | $34.99 | 33 | 1,155 | 2,810 | Jul 17, 2020, 04:03 PM |
| Hearne Michael S | Chief Financial Officer | Jun 30, 2020 | Option Exercise | $35.99 | 15 | 540 | 1,695 | Jul 02, 2020, 04:25 PM |
| O'Connell Joseph P | Chief Medical Officer | Jun 30, 2020 | Option Exercise | $35.99 | 26 | 936 | 2,074 | Jul 02, 2020, 04:22 PM |
| Lemkey John G | Chief Operating Officer | Jun 30, 2020 | Option Exercise | $35.99 | 33 | 1,188 | 2,777 | Jul 02, 2020, 04:20 PM |
| Hearne Michael S | Chief Financial Officer | Jun 15, 2020 | Option Exercise | $34.21 | 17 | 582 | 1,680 | Jun 17, 2020, 04:27 PM |
| O'Connell Joseph P | Chief Medical Officer | Jun 15, 2020 | Option Exercise | $34.21 | 27 | 924 | 2,048 | Jun 17, 2020, 04:27 PM |
| Lemkey John G | Chief Operating Officer | Jun 15, 2020 | Option Exercise | $34.21 | 34 | 1,163 | 2,744 | Jun 17, 2020, 04:26 PM |
| Hearne Michael S | Chief Financial Officer | May 29, 2020 | Option Exercise | $27.77 | 40 | 1,111 | 1,663 | Jun 02, 2020, 04:04 PM |
| O'Connell Joseph P | Chief Medical Officer | May 29, 2020 | Option Exercise | $27.77 | 34 | 944 | 2,021 | Jun 02, 2020, 04:04 PM |
| Lemkey John G | Chief Operating Officer | May 29, 2020 | Option Exercise | $27.77 | 42 | 1,166 | 2,710 | Jun 02, 2020, 04:03 PM |
| Hearne Michael S | Chief Financial Officer | May 15, 2020 | Option Exercise | $24.00 | 47 | 1,128 | 1,623 | May 19, 2020, 08:14 PM |
| O'Connell Joseph P | Chief Medical Officer | May 15, 2020 | Option Exercise | $24.00 | 39 | 936 | 1,987 | May 19, 2020, 08:14 PM |
| Lemkey John G | Chief Operating Officer | May 15, 2020 | Option Exercise | $24.00 | 49 | 1,176 | 2,668 | May 19, 2020, 08:13 PM |
| Hearne Michael S | Chief Financial Officer | Apr 30, 2020 | Option Exercise | $23.93 | 47 | 1,125 | 1,576 | May 04, 2020, 04:03 PM |
| O'Connell Joseph P | Chief Medical Officer | Apr 30, 2020 | Option Exercise | $23.93 | 39 | 933 | 1,948 | May 04, 2020, 04:02 PM |
| Lemkey John G | Chief Operating Officer | Apr 30, 2020 | Option Exercise | $23.93 | 49 | 1,173 | 2,619 | May 04, 2020, 04:02 PM |
| Hearne Michael S | Chief Financial Officer | Apr 15, 2020 | Option Exercise | $22.82 | 50 | 1,141 | 1,529 | Apr 17, 2020, 04:07 PM |
| O'Connell Joseph P | Chief Medical Officer | Apr 15, 2020 | Option Exercise | $22.82 | 41 | 936 | 1,909 | Apr 17, 2020, 04:06 PM |
| Lemkey John G | Chief Operating Officer | Apr 15, 2020 | Option Exercise | $22.82 | 51 | 1,164 | 2,570 | Apr 17, 2020, 04:03 PM |
| Hearne Michael S | Chief Financial Officer | Mar 31, 2020 | Option Exercise | $23.47 | 24 | 563 | 1,479 | Apr 02, 2020, 04:13 PM |
| O'Connell Joseph P | Chief Medical Officer | Mar 31, 2020 | Option Exercise | $23.47 | 40 | 939 | 1,868 | Apr 02, 2020, 04:12 PM |
| Lemkey John G | Chief Operating Officer | Mar 31, 2020 | Option Exercise | $23.47 | 50 | 1,173 | 2,519 | Apr 02, 2020, 04:12 PM |
| Hearne Michael S | Chief Financial Officer | Mar 13, 2020 | Option Exercise | $19.59 | 29 | 568 | 1,455 | Mar 17, 2020, 04:17 PM |
| O'Connell Joseph P | Chief Medical Officer | Mar 13, 2020 | Option Exercise | $19.59 | 48 | 940 | 1,828 | Mar 17, 2020, 04:14 PM |
| Lemkey John G | Chief Operating Officer | Mar 13, 2020 | Option Exercise | $19.59 | 60 | 1,175 | 2,469 | Mar 17, 2020, 04:12 PM |
| Hearne Michael S | Chief Financial Officer | Feb 28, 2020 | Option Exercise | $25.15 | 22 | 553 | 1,426 | Mar 03, 2020, 04:05 PM |
| O'Connell Joseph P | Chief Medical Officer | Feb 28, 2020 | Option Exercise | $25.15 | 37 | 931 | 1,780 | Mar 03, 2020, 04:05 PM |
| Lemkey John G | Chief Operating Officer | Feb 28, 2020 | Option Exercise | $25.15 | 47 | 1,182 | 2,409 | Mar 03, 2020, 04:04 PM |
| Hearne Michael S | Chief Financial Officer | Feb 14, 2020 | Option Exercise | $26.73 | 21 | 561 | 1,404 | Feb 19, 2020, 04:12 PM |
| O'Connell Joseph P | Chief Medical Officer | Feb 14, 2020 | Option Exercise | $26.73 | 35 | 936 | 1,743 | Feb 19, 2020, 04:12 PM |
| Lemkey John G | Chief Operating Officer | Feb 14, 2020 | Option Exercise | $26.73 | 43 | 1,149 | 2,362 | Feb 19, 2020, 04:11 PM |
| Hearne Michael S | Chief Financial Officer | Jan 31, 2020 | Option Exercise | $24.82 | 23 | 571 | 1,383 | Feb 04, 2020, 04:31 PM |
| O'Connell Joseph P | Chief Medical Officer | Jan 31, 2020 | Option Exercise | $24.82 | 38 | 943 | 1,708 | Feb 04, 2020, 04:30 PM |
| Lemkey John G | Chief Operating Officer | Jan 31, 2020 | Option Exercise | $24.82 | 48 | 1,191 | 2,319 | Feb 04, 2020, 04:30 PM |
| Hearne Michael S | Chief Financial Officer | Jan 15, 2020 | Option Exercise | $23.15 | 24 | 556 | 1,360 | Jan 17, 2020, 04:02 PM |
| O'Connell Joseph P | Chief Medical Officer | Jan 15, 2020 | Option Exercise | $23.15 | 40 | 926 | 1,670 | Jan 17, 2020, 04:02 PM |
| Lemkey John G | Chief Operating Officer | Jan 15, 2020 | Option Exercise | $23.15 | 50 | 1,157 | 2,271 | Jan 17, 2020, 04:01 PM |
| Hearne Michael S | Chief Financial Officer | Dec 31, 2019 | Option Exercise | $27.58 | 20 | 552 | 1,336 | Jan 03, 2020, 04:04 PM |
| O'Connell Joseph P | Chief Medical Officer | Dec 31, 2019 | Option Exercise | $27.58 | 33 | 910 | 1,630 | Jan 03, 2020, 04:03 PM |
| Lemkey John G | Chief Operating Officer | Dec 31, 2019 | Option Exercise | $27.58 | 41 | 1,131 | 2,221 | Jan 03, 2020, 04:02 PM |
| Hearne Michael S | Chief Financial Officer | Dec 13, 2019 | Option Exercise | $24.62 | 22 | 542 | 1,316 | Dec 17, 2019, 04:05 PM |
| O'Connell Joseph P | Chief Medical Officer | Dec 13, 2019 | Option Exercise | $24.62 | 37 | 911 | 1,597 | Dec 17, 2019, 04:05 PM |
| Lemkey John G | Chief Operating Officer | Dec 13, 2019 | Option Exercise | $24.62 | 47 | 1,157 | 2,180 | Dec 17, 2019, 04:04 PM |
| Hearne Michael S | Chief Financial Officer | Nov 29, 2019 | Option Exercise | $29.22 | 19 | 555 | 1,294 | Dec 03, 2019, 04:02 PM |
| O'Connell Joseph P | Chief Medical Officer | Nov 29, 2019 | Option Exercise | $29.22 | 31 | 906 | 1,560 | Dec 03, 2019, 04:02 PM |
| Lemkey John G | Chief Operating Officer | Nov 29, 2019 | Option Exercise | $29.22 | 39 | 1,140 | 2,133 | Dec 03, 2019, 04:01 PM |
| Hearne Michael S | Chief Financial Officer | Nov 15, 2019 | Option Exercise | $28.14 | 19 | 535 | 1,275 | Nov 19, 2019, 06:04 PM |
| O'Connell Joseph P | Chief Medical Officer | Nov 15, 2019 | Option Exercise | $28.14 | 33 | 929 | 1,529 | Nov 19, 2019, 06:03 PM |
| Lemkey John G | Chief Operating Officer | Nov 15, 2019 | Option Exercise | $28.14 | 40 | 1,126 | 2,094 | Nov 19, 2019, 06:02 PM |
| Hearne Michael S | Chief Financial Officer | Oct 31, 2019 | Option Exercise | $27.00 | 21 | 567 | 1,256 | Nov 04, 2019, 04:11 PM |
| O'Connell Joseph P | Chief Medical Officer | Oct 31, 2019 | Option Exercise | $27.00 | 33 | 891 | 1,496 | Nov 04, 2019, 04:11 PM |
| Lemkey John G | Chief Operating Officer | Oct 31, 2019 | Option Exercise | $27.00 | 42 | 1,134 | 2,054 | Nov 04, 2019, 04:10 PM |
| Hearne Michael S | Chief Financial Officer | Oct 15, 2019 | Option Exercise | $24.23 | 22 | 533 | 1,235 | Oct 17, 2019, 05:46 PM |
| O'Connell Joseph P | Chief Medical Officer | Oct 15, 2019 | Option Exercise | $24.23 | 38 | 921 | 1,463 | Oct 17, 2019, 05:45 PM |
| Lemkey John G | Chief Operating Officer | Oct 15, 2019 | Option Exercise | $24.23 | 47 | 1,139 | 2,012 | Oct 17, 2019, 05:44 PM |
| Hearne Michael S | Chief Financial Officer | Sep 30, 2019 | Option Exercise | $22.13 | 25 | 553 | 1,213 | Oct 02, 2019, 04:02 PM |
| O'Connell Joseph P | Chief Medical Officer | Sep 30, 2019 | Option Exercise | $22.13 | 41 | 907 | 1,425 | Oct 02, 2019, 12:00 AM |
| Lemkey John G | Chief Operating Officer | Sep 30, 2019 | Option Exercise | $22.13 | 51 | 1,129 | 1,965 | Oct 02, 2019, 12:00 AM |
| Hearne Michael S | Chief Financial Officer | Sep 13, 2019 | Option Exercise | $24.11 | 23 | 555 | 1,188 | Sep 17, 2019, 07:24 PM |
| O'Connell Joseph P | Chief Medical Officer | Sep 13, 2019 | Option Exercise | $24.11 | 38 | 916 | 1,384 | Sep 17, 2019, 07:23 PM |
| Lemkey John G | Chief Operating Officer | Sep 13, 2019 | Option Exercise | $24.11 | 48 | 1,157 | 1,914 | Sep 17, 2019, 07:23 PM |
| Hearne Michael S | Chief Financial Officer | Aug 30, 2019 | Option Exercise | $26.19 | 21 | 550 | 1,165 | Sep 04, 2019, 04:18 PM |
| O'Connell Joseph P | Chief Medical Officer | Aug 30, 2019 | Option Exercise | $26.19 | 34 | 890 | 1,346 | Sep 04, 2019, 04:18 PM |
| Lemkey John G | Chief Operating Officer | Aug 30, 2019 | Option Exercise | $26.19 | 43 | 1,126 | 1,866 | Sep 04, 2019, 04:17 PM |
| Hearne Michael S | Chief Financial Officer | Aug 15, 2019 | Option Exercise | $28.42 | 19 | 540 | 1,144 | Aug 19, 2019, 04:12 PM |
| O'Connell Joseph P | Chief Medical Officer | Aug 15, 2019 | Option Exercise | $28.42 | 33 | 938 | 1,312 | Aug 19, 2019, 04:11 PM |
| Lemkey John G | Chief Operating Officer | Aug 15, 2019 | Option Exercise | $28.42 | 40 | 1,137 | 1,823 | Aug 19, 2019, 04:10 PM |
| Hearne Michael S | Chief Financial Officer | Jul 31, 2019 | Option Exercise | $34.64 | 16 | 554 | 1,125 | Aug 02, 2019, 04:05 PM |
| O'Connell Joseph P | Chief Medical Officer | Jul 31, 2019 | Option Exercise | $34.64 | 26 | 901 | 1,279 | Aug 02, 2019, 04:04 PM |
| Lemkey John G | Chief Operating Officer | Jul 31, 2019 | Option Exercise | $34.64 | 33 | 1,143 | 1,783 | Aug 02, 2019, 04:04 PM |
| Hearne Michael S | Chief Financial Officer | Jul 15, 2019 | Option Exercise | $29.89 | 18 | 538 | 1,109 | Jul 17, 2019, 06:53 PM |
| O'Connell Joseph P | Chief Medical Officer | Jul 15, 2019 | Option Exercise | $29.89 | 30 | 897 | 1,253 | Jul 17, 2019, 06:52 PM |
| Lemkey John G | Chief Operating Officer | Jul 15, 2019 | Option Exercise | $29.89 | 38 | 1,136 | 1,750 | Jul 17, 2019, 06:52 PM |
| Hearne Michael S | Chief Financial Officer | Jun 28, 2019 | Option Exercise | $31.19 | 17 | 530 | 1,091 | Jul 02, 2019, 06:40 PM |
| O'Connell Joseph P | Chief Medical Officer | Jun 28, 2019 | Option Exercise | $31.19 | 29 | 905 | 1,223 | Jul 02, 2019, 06:40 PM |
| Lemkey John G | Chief Operating Officer | Jun 28, 2019 | Option Exercise | $31.19 | 36 | 1,123 | 1,712 | Jul 02, 2019, 06:39 PM |
| Boxer Capital, LLC | 10% Owner | Jun 26, 2019 | Buy | $26.00 | 384,615 | 9,999,990 | 3,363,377 | Jun 28, 2019, 04:30 PM |
| Vacirca Jeff L | Director | Jun 26, 2019 | Buy | $26.00 | 19,231 | 500,006 | 23,231 | Jun 28, 2019, 04:03 PM |
| TANG KEVIN C | Chief Executive Officer | Jun 26, 2019 | Buy | $26.00 | 769,231 | 20,000,006 | 14,075,269 | Jun 28, 2019, 04:01 PM |
| TANG KEVIN C | Chief Executive Officer | Jun 18, 2019 | Buy | $26.89 | 21,350 | 574,020 | 13,306,038 | Jun 18, 2019, 09:43 PM |
| TANG KEVIN C | Chief Executive Officer | Jun 17, 2019 | Buy | $26.81 | 10,042 | 269,231 | 13,284,688 | Jun 18, 2019, 09:43 PM |
| TANG KEVIN C | Chief Executive Officer | Jun 14, 2019 | Buy | $24.95 | 18,608 | 464,294 | 13,274,646 | Jun 18, 2019, 09:43 PM |
| Hearne Michael S | Chief Financial Officer | Jun 14, 2019 | Option Exercise | $21.25 | 26 | 553 | 1,074 | Jun 18, 2019, 06:49 PM |
| O'Connell Joseph P | Chief Medical Officer | Jun 14, 2019 | Option Exercise | $21.25 | 43 | 914 | 1,194 | Jun 18, 2019, 06:48 PM |
| Lemkey John G | Chief Operating Officer | Jun 14, 2019 | Option Exercise | $21.25 | 54 | 1,148 | 1,676 | Jun 18, 2019, 06:48 PM |
| TANG KEVIN C | Chief Executive Officer | Jun 07, 2019 | Buy | $26.31 | 20,000 | 526,220 | 13,256,038 | Jun 10, 2019, 07:15 PM |
| TANG KEVIN C | Chief Executive Officer | Jun 06, 2019 | Buy | $27.73 | 56,308 | 1,561,237 | 13,236,038 | Jun 10, 2019, 07:15 PM |
| TANG KEVIN C | Chief Executive Officer | Jun 03, 2019 | Buy | $22.50 | 15,286 | 343,904 | 13,101,324 | Jun 05, 2019, 05:41 PM |
| TANG KEVIN C | Chief Executive Officer | Jun 05, 2019 | Buy | $25.87 | 39,456 | 1,020,541 | 13,179,730 | Jun 05, 2019, 05:41 PM |
| TANG KEVIN C | Chief Executive Officer | Jun 04, 2019 | Buy | $24.92 | 38,950 | 970,772 | 13,140,274 | Jun 05, 2019, 05:41 PM |
| Hearne Michael S | Chief Financial Officer | May 31, 2019 | Option Exercise | $18.27 | 30 | 548 | 1,048 | Jun 04, 2019, 04:33 PM |
| O'Connell Joseph P | Chief Medical Officer | May 31, 2019 | Option Exercise | $18.27 | 50 | 914 | 1,151 | Jun 04, 2019, 04:33 PM |
| Lemkey John G | Chief Operating Officer | May 31, 2019 | Option Exercise | $18.27 | 62 | 1,133 | 1,622 | Jun 04, 2019, 04:32 PM |
| Hearne Michael S | Chief Financial Officer | May 15, 2019 | Option Exercise | $18.87 | 29 | 547 | 1,018 | May 17, 2019, 06:05 PM |
| O'Connell Joseph P | Chief Medical Officer | May 15, 2019 | Option Exercise | $18.87 | 48 | 906 | 1,101 | May 17, 2019, 06:05 PM |
| Lemkey John G | Chief Operating Officer | May 15, 2019 | Option Exercise | $18.87 | 60 | 1,132 | 1,560 | May 17, 2019, 06:04 PM |
| Hearne Michael S | Chief Financial Officer | Apr 30, 2019 | Option Exercise | $16.71 | 33 | 551 | 989 | May 02, 2019, 07:58 PM |
| O'Connell Joseph P | Chief Medical Officer | Apr 30, 2019 | Option Exercise | $16.71 | 55 | 919 | 1,053 | May 02, 2019, 07:58 PM |
| Lemkey John G | Chief Operating Officer | Apr 30, 2019 | Option Exercise | $16.71 | 69 | 1,153 | 1,500 | May 02, 2019, 07:57 PM |
| Hearne Michael S | Chief Financial Officer | Apr 15, 2019 | Option Exercise | $21.24 | 26 | 552 | 956 | Apr 17, 2019, 04:04 PM |
| O'Connell Joseph P | Chief Medical Officer | Apr 15, 2019 | Option Exercise | $21.24 | 43 | 913 | 998 | Apr 17, 2019, 04:03 PM |
| Lemkey John G | Chief Operating Officer | Apr 15, 2019 | Option Exercise | $21.24 | 53 | 1,126 | 1,431 | Apr 17, 2019, 04:03 PM |
| Hearne Michael S | Chief Financial Officer | Mar 29, 2019 | Option Exercise | $18.79 | 29 | 545 | 930 | Apr 02, 2019, 12:00 AM |
| O'Connell Joseph P | Chief Medical Officer | Mar 29, 2019 | Option Exercise | $18.79 | 48 | 902 | 955 | Apr 02, 2019, 12:00 AM |
| Lemkey John G | Chief Operating Officer | Mar 29, 2019 | Option Exercise | $18.79 | 61 | 1,146 | 1,378 | Apr 02, 2019, 12:00 AM |
| O'Connell Joseph P | Chief Medical Officer | Mar 15, 2019 | Option Exercise | $20.19 | 45 | 909 | 907 | Mar 19, 2019, 04:05 PM |
| Hearne Michael S | Chief Financial Officer | Mar 15, 2019 | Option Exercise | $20.19 | 27 | 545 | 901 | Mar 19, 2019, 04:04 PM |
| Lemkey John G | Chief Operating Officer | Mar 15, 2019 | Option Exercise | $20.19 | 56 | 1,131 | 1,317 | Mar 19, 2019, 04:03 PM |
| TANG KEVIN C | Chief Executive Officer | Mar 07, 2019 | Buy | $17.04 | 40,000 | 681,733 | 12,986,038 | Mar 11, 2019, 05:42 PM |
| TANG KEVIN C | Chief Executive Officer | Mar 08, 2019 | Buy | $18.75 | 100,000 | 1,874,583 | 13,086,038 | Mar 11, 2019, 05:42 PM |
| Vacirca Jeff L | Director | Mar 04, 2019 | Buy | $17.00 | 3,000 | 51,000 | 4,000 | Mar 07, 2019, 04:57 PM |
| O'Connell Joseph P | Chief Medical Officer | Feb 28, 2019 | Option Exercise | $14.01 | 65 | 911 | 862 | Mar 04, 2019, 04:47 PM |
| Lemkey John G | Chief Operating Officer | Feb 28, 2019 | Option Exercise | $14.01 | 81 | 1,135 | 1,261 | Mar 04, 2019, 04:47 PM |
| Hearne Michael S | Chief Financial Officer | Feb 28, 2019 | Option Exercise | $14.01 | 39 | 546 | 874 | Mar 04, 2019, 12:00 AM |
| Hearne Michael S | Chief Financial Officer | Feb 15, 2019 | Option Exercise | $14.04 | 39 | 548 | 835 | Feb 20, 2019, 05:30 PM |
| O'Connell Joseph P | Chief Medical Officer | Feb 15, 2019 | Option Exercise | $14.04 | 65 | 913 | 797 | Feb 20, 2019, 05:29 PM |
| Lemkey John G | Chief Operating Officer | Feb 15, 2019 | Option Exercise | $14.04 | 81 | 1,137 | 1,180 | Feb 20, 2019, 05:29 PM |
| Hearne Michael S | Chief Financial Officer | Jan 31, 2019 | Option Exercise | $14.08 | 38 | 535 | 796 | Feb 04, 2019, 09:31 PM |
| O'Connell Joseph P | Chief Medical Officer | Jan 31, 2019 | Option Exercise | $14.08 | 64 | 901 | 732 | Feb 04, 2019, 09:31 PM |
| Lemkey John G | Chief Operating Officer | Jan 31, 2019 | Option Exercise | $14.08 | 81 | 1,140 | 1,099 | Feb 04, 2019, 09:30 PM |
| Hearne Michael S | Chief Financial Officer | Jan 15, 2019 | Option Exercise | $13.85 | 40 | 554 | 758 | Jan 17, 2019, 07:15 PM |
| O'Connell Joseph P | Chief Medical Officer | Jan 15, 2019 | Option Exercise | $13.85 | 66 | 914 | 668 | Jan 17, 2019, 07:12 PM |
| Lemkey John G | Chief Operating Officer | Jan 15, 2019 | Option Exercise | $13.85 | 82 | 1,136 | 1,018 | Jan 17, 2019, 07:11 PM |
| Hearne Michael S | Chief Financial Officer | Dec 31, 2018 | Option Exercise | $11.97 | 45 | 539 | 718 | Jan 03, 2019, 08:10 PM |
| O'Connell Joseph P | Chief Medical Officer | Dec 31, 2018 | Option Exercise | $11.97 | 74 | 886 | 602 | Jan 03, 2019, 08:09 PM |
| Lemkey John G | Chief Operating Officer | Dec 31, 2018 | Option Exercise | $11.97 | 70 | 838 | 936 | Jan 03, 2019, 08:09 PM |
| TANG KEVIN C | Chief Executive Officer | Dec 27, 2018 | Buy | $12.03 | 10,000 | 120,315 | 12,892,338 | Dec 31, 2018, 05:17 PM |
| TANG KEVIN C | Chief Executive Officer | Dec 31, 2018 | Buy | $13.68 | 33,700 | 460,929 | 12,946,038 | Dec 31, 2018, 05:17 PM |
| TANG KEVIN C | Chief Executive Officer | Dec 28, 2018 | Buy | $12.69 | 20,000 | 253,863 | 12,912,338 | Dec 31, 2018, 05:17 PM |
| Davis Aaron I. | Director | Dec 26, 2018 | Buy | $12.47 | 25,000 | 311,815 | 2,978,762 | Dec 27, 2018, 05:01 PM |
| Davis Aaron I. | Director | Dec 21, 2018 | Buy | $13.47 | 100,000 | 1,347,015 | 2,953,762 | Dec 27, 2018, 05:01 PM |
| Boxer Capital, LLC | Director | Dec 26, 2018 | Buy | $12.47 | 25,000 | 311,815 | 2,978,762 | Dec 27, 2018, 05:00 PM |
| Boxer Capital, LLC | Director | Dec 21, 2018 | Buy | $13.47 | 100,000 | 1,347,015 | 2,953,762 | Dec 27, 2018, 05:00 PM |
| TANG KEVIN C | Chief Executive Officer | Dec 20, 2018 | Buy | $13.17 | 10,000 | 131,742 | 12,832,338 | Dec 26, 2018, 06:21 PM |
| TANG KEVIN C | Chief Executive Officer | Dec 26, 2018 | Buy | $12.28 | 30,000 | 368,287 | 12,882,338 | Dec 26, 2018, 06:21 PM |
| TANG KEVIN C | Chief Executive Officer | Dec 21, 2018 | Buy | $12.79 | 20,000 | 255,828 | 12,852,338 | Dec 26, 2018, 06:21 PM |
| Hearne Michael S | Chief Financial Officer | Dec 14, 2018 | Option Exercise | $12.85 | 42 | 540 | 673 | Dec 18, 2018, 06:00 PM |
| O'Connell Joseph P | Chief Medical Officer | Dec 14, 2018 | Option Exercise | $12.85 | 68 | 874 | 528 | Dec 18, 2018, 06:00 PM |
| Lemkey John G | Chief Operating Officer | Dec 14, 2018 | Option Exercise | $12.85 | 64 | 822 | 866 | Dec 18, 2018, 05:59 PM |
| TANG KEVIN C | Chief Executive Officer | Dec 18, 2018 | Buy | $14.28 | 11,704 | 167,189 | 12,822,338 | Dec 18, 2018, 05:58 PM |
| TANG KEVIN C | Chief Executive Officer | Dec 17, 2018 | Buy | $14.68 | 18,296 | 268,612 | 12,810,634 | Dec 18, 2018, 05:58 PM |
| TANG KEVIN C | Chief Executive Officer | Dec 14, 2018 | Buy | $15.08 | 10,000 | 150,838 | 12,792,338 | Dec 18, 2018, 05:58 PM |
| TANG KEVIN C | Chief Executive Officer | Dec 12, 2018 | Buy | $15.74 | 14,550 | 228,946 | 12,782,338 | Dec 13, 2018, 08:18 PM |
| TANG KEVIN C | Chief Executive Officer | Dec 11, 2018 | Buy | $15.25 | 5,450 | 83,128 | 12,767,788 | Dec 13, 2018, 08:18 PM |
| TANG KEVIN C | Chief Executive Officer | Dec 07, 2018 | Buy | $14.98 | 9,500 | 142,291 | 12,762,338 | Dec 10, 2018, 06:24 PM |
| TANG KEVIN C | Chief Executive Officer | Dec 06, 2018 | Buy | $14.63 | 10,500 | 153,573 | 12,752,838 | Dec 10, 2018, 06:24 PM |
| Hearne Michael S | Chief Financial Officer | Nov 30, 2018 | Option Exercise | $13.40 | 40 | 536 | 631 | Dec 04, 2018, 06:27 PM |
| O'Connell Joseph P | Chief Medical Officer | Nov 30, 2018 | Option Exercise | $13.40 | 66 | 884 | 460 | Dec 04, 2018, 06:26 PM |
| Lemkey John G | Chief Operating Officer | Nov 30, 2018 | Option Exercise | $13.40 | 63 | 844 | 802 | Dec 04, 2018, 06:25 PM |
| TANG KEVIN C | Chief Executive Officer | Nov 27, 2018 | Buy | $15.64 | 3,063 | 47,912 | 12,742,338 | Nov 29, 2018, 04:34 PM |
| TANG KEVIN C | Chief Executive Officer | Nov 26, 2018 | Buy | $15.43 | 6,937 | 107,046 | 12,739,275 | Nov 26, 2018, 07:49 PM |
| TANG KEVIN C | Chief Executive Officer | Nov 23, 2018 | Buy | $15.25 | 4,644 | 70,830 | 12,732,338 | Nov 26, 2018, 07:49 PM |
| TANG KEVIN C | Chief Executive Officer | Nov 21, 2018 | Buy | $15.15 | 5,356 | 81,141 | 12,727,694 | Nov 26, 2018, 07:49 PM |
| O'Connell Joseph P | Chief Medical Officer | Nov 15, 2018 | Option Exercise | $14.04 | 63 | 885 | 394 | Nov 19, 2018, 07:18 PM |
| Lemkey John G | Chief Financial Officer | Nov 15, 2018 | Option Exercise | $14.04 | 59 | 828 | 739 | Nov 19, 2018, 07:17 PM |
| TANG KEVIN C | Chief Executive Officer | Nov 01, 2018 | Buy | $14.87 | 10,000 | 148,727 | 12,722,338 | Nov 05, 2018, 09:31 PM |
| O'Connell Joseph P | Chief Medical Officer | Oct 31, 2018 | Option Exercise | $12.33 | 72 | 888 | 331 | Nov 02, 2018, 05:21 PM |
| Lemkey John G | Chief Financial Officer | Oct 31, 2018 | Option Exercise | $12.33 | 67 | 826 | 680 | Nov 02, 2018, 05:20 PM |
| TANG KEVIN C | Chief Executive Officer | Oct 29, 2018 | Buy | $14.96 | 10,000 | 149,642 | 12,712,338 | Oct 30, 2018, 04:24 PM |
| TANG KEVIN C | Chief Executive Officer | Oct 26, 2018 | Buy | $15.85 | 235 | 3,725 | 12,702,338 | Oct 30, 2018, 04:24 PM |
| Davis Aaron I. | Director | Oct 24, 2018 | Buy | $14.72 | 26,824 | 394,753 | 2,853,762 | Oct 26, 2018, 04:32 PM |
| Boxer Capital, LLC | Director | Oct 24, 2018 | Buy | $14.72 | 26,824 | 394,753 | 2,853,762 | Oct 26, 2018, 04:30 PM |
| TANG KEVIN C | Chief Executive Officer | Oct 25, 2018 | Buy | $15.78 | 9,765 | 154,059 | 12,702,103 | Oct 25, 2018, 07:31 PM |
| TANG KEVIN C | Chief Executive Officer | Oct 24, 2018 | Buy | $14.92 | 13,313 | 198,632 | 12,692,338 | Oct 25, 2018, 07:31 PM |
| TANG KEVIN C | Chief Executive Officer | Oct 23, 2018 | Buy | $15.44 | 16,687 | 257,609 | 12,679,025 | Oct 25, 2018, 07:31 PM |
| O'Connell Joseph P | Chief Medical Officer | Oct 15, 2018 | Option Exercise | $13.68 | 64 | 876 | 259 | Oct 17, 2018, 04:01 PM |
| Lemkey John G | Chief Financial Officer | Oct 15, 2018 | Option Exercise | $13.68 | 61 | 834 | 613 | Oct 17, 2018, 04:01 PM |
| O'Connell Joseph P | Chief Medical Officer | Sep 28, 2018 | Option Exercise | $16.50 | 18 | 297 | 195 | Oct 02, 2018, 04:04 PM |
| Lemkey John G | Chief Financial Officer | Sep 28, 2018 | Option Exercise | $16.50 | 51 | 842 | 552 | Oct 02, 2018, 04:03 PM |
| TANG KEVIN C | Chief Executive Officer | Sep 28, 2018 | Buy | $19.24 | 33,801 | 650,378 | 12,662,338 | Oct 01, 2018, 04:23 PM |
| TANG KEVIN C | Chief Executive Officer | Sep 27, 2018 | Buy | $18.70 | 6,199 | 115,929 | 12,628,537 | Oct 01, 2018, 04:23 PM |
| TANG KEVIN C | Chief Executive Officer | Sep 26, 2018 | Buy | $19.07 | 10,000 | 190,664 | 12,622,338 | Sep 26, 2018, 05:16 PM |
| TANG KEVIN C | Chief Executive Officer | Sep 25, 2018 | Buy | $19.65 | 10,000 | 196,477 | 12,612,338 | Sep 26, 2018, 05:16 PM |
| TANG KEVIN C | Chief Executive Officer | Sep 24, 2018 | Buy | $20.14 | 20,000 | 402,832 | 12,602,338 | Sep 26, 2018, 05:16 PM |
| TANG KEVIN C | Chief Executive Officer | Sep 20, 2018 | Buy | $20.11 | 27,983 | 562,736 | 12,582,338 | Sep 20, 2018, 08:01 PM |
| TANG KEVIN C | Chief Executive Officer | Sep 19, 2018 | Buy | $19.34 | 12,017 | 232,374 | 12,554,355 | Sep 20, 2018, 08:01 PM |
| TANG KEVIN C | Chief Executive Officer | Sep 18, 2018 | Buy | $19.28 | 50,000 | 964,186 | 12,542,338 | Sep 20, 2018, 08:01 PM |
| O'Connell Joseph P | Chief Medical Officer | Sep 14, 2018 | Option Exercise | $16.26 | 18 | 293 | 177 | Sep 18, 2018, 04:02 PM |
| Lemkey John G | Chief Financial Officer | Sep 14, 2018 | Option Exercise | $16.26 | 51 | 829 | 501 | Sep 18, 2018, 04:02 PM |
| O'Connell Joseph P | Chief Medical Officer | Aug 31, 2018 | Option Exercise | $16.31 | 18 | 294 | 159 | Sep 05, 2018, 04:01 PM |
| Lemkey John G | Chief Financial Officer | Aug 31, 2018 | Option Exercise | $16.31 | 51 | 832 | 450 | Sep 05, 2018, 04:01 PM |
| TANG KEVIN C | Chief Executive Officer | Aug 21, 2018 | Buy | $19.47 | 7,505 | 146,151 | 12,492,338 | Aug 23, 2018, 06:06 PM |
| TANG KEVIN C | Chief Executive Officer | Aug 20, 2018 | Buy | $18.96 | 10,108 | 191,613 | 12,484,833 | Aug 20, 2018, 06:10 PM |
| TANG KEVIN C | Chief Executive Officer | Aug 17, 2018 | Buy | $19.26 | 2,387 | 45,980 | 12,474,725 | Aug 20, 2018, 06:10 PM |
| TANG KEVIN C | Chief Executive Officer | Aug 16, 2018 | Buy | $19.65 | 37,190 | 730,681 | 12,472,338 | Aug 20, 2018, 06:10 PM |
| O'Connell Joseph P | Chief Medical Officer | Aug 15, 2018 | Option Exercise | $15.93 | 19 | 303 | 141 | Aug 17, 2018, 06:22 PM |
| Lemkey John G | Chief Financial Officer | Aug 15, 2018 | Option Exercise | $15.93 | 53 | 844 | 399 | Aug 17, 2018, 06:21 PM |
| TANG KEVIN C | Chief Executive Officer | Aug 15, 2018 | Buy | $19.04 | 9,416 | 179,242 | 12,435,148 | Aug 15, 2018, 05:42 PM |
| TANG KEVIN C | Chief Executive Officer | Aug 14, 2018 | Buy | $18.98 | 6,603 | 125,352 | 12,425,732 | Aug 15, 2018, 05:42 PM |
| TANG KEVIN C | Chief Executive Officer | Aug 13, 2018 | Buy | $18.72 | 6,791 | 127,111 | 12,419,129 | Aug 15, 2018, 05:42 PM |
| O'Connell Joseph P | Chief Medical Officer | Jul 31, 2018 | Option Exercise | $16.80 | 17 | 286 | 122 | Aug 02, 2018, 04:02 PM |
| Lemkey John G | Chief Financial Officer | Jul 31, 2018 | Option Exercise | $16.80 | 49 | 823 | 346 | Aug 02, 2018, 04:01 PM |
| O'Connell Joseph P | Chief Medical Officer | Jul 13, 2018 | Option Exercise | $20.36 | 15 | 305 | 105 | Jul 17, 2018, 04:01 PM |
| Lemkey John G | Chief Financial Officer | Jul 13, 2018 | Option Exercise | $20.36 | 41 | 835 | 297 | Jul 17, 2018, 04:01 PM |
| O'Connell Joseph P | Chief Medical Officer | Jun 29, 2018 | Option Exercise | $18.77 | 16 | 300 | 90 | Jul 03, 2018, 01:15 PM |
| Lemkey John G | Chief Financial Officer | Jun 29, 2018 | Option Exercise | $18.77 | 45 | 845 | 256 | Jul 03, 2018, 01:14 PM |
| O'Connell Joseph P | Chief Medical Officer | Jun 15, 2018 | Option Exercise | $22.54 | 13 | 293 | 74 | Jun 19, 2018, 04:06 PM |
| Lemkey John G | Chief Financial Officer | Jun 15, 2018 | Option Exercise | $22.54 | 37 | 834 | 211 | Jun 19, 2018, 04:05 PM |
| O'Connell Joseph P | Chief Medical Officer | May 31, 2018 | Option Exercise | $20.39 | 14 | 285 | 61 | Jun 04, 2018, 04:01 PM |
| Lemkey John G | Chief Financial Officer | May 31, 2018 | Option Exercise | $20.39 | 40 | 816 | 174 | Jun 04, 2018, 04:00 PM |
| O'Connell Joseph P | Chief Medical Officer | May 15, 2018 | Option Exercise | $19.69 | 15 | 295 | 47 | May 17, 2018, 04:05 PM |
| Lemkey John G | Chief Financial Officer | May 15, 2018 | Option Exercise | $19.69 | 43 | 847 | 134 | May 17, 2018, 04:04 PM |
| O'Connell Joseph P | Chief Medical Officer | Apr 30, 2018 | Option Exercise | $17.92 | 17 | 305 | 32 | May 02, 2018, 04:23 PM |
| Lemkey John G | Chief Financial Officer | Apr 30, 2018 | Option Exercise | $17.92 | 46 | 824 | 91 | May 02, 2018, 04:22 PM |
| O'Connell Joseph P | Chief Medical Officer | Apr 13, 2018 | Option Exercise | $18.41 | 15 | 276 | 15 | Apr 17, 2018, 04:16 PM |
| Lemkey John G | Chief Financial Officer | Apr 13, 2018 | Option Exercise | $18.41 | 45 | 828 | 45 | Apr 17, 2018, 04:15 PM |
| Boxer Capital, LLC | Director | Mar 26, 2018 | Buy | $22.41 | 33,650 | 754,096 | 2,826,938 | Mar 26, 2018, 06:59 PM |
| Boxer Capital, LLC | Director | Mar 23, 2018 | Buy | $23.96 | 42,943 | 1,028,914 | 2,793,288 | Mar 26, 2018, 06:59 PM |
| Boxer Capital, LLC | Director | Mar 22, 2018 | Buy | $20.94 | 23,407 | 490,143 | 2,750,345 | Mar 26, 2018, 06:59 PM |
| Davis Aaron I. | Director | Mar 26, 2018 | Buy | $22.41 | 33,650 | 754,096 | 2,826,938 | Mar 26, 2018, 06:56 PM |
| Davis Aaron I. | Director | Mar 23, 2018 | Buy | $23.96 | 42,943 | 1,028,914 | 2,793,288 | Mar 26, 2018, 06:56 PM |
| Davis Aaron I. | Director | Mar 22, 2018 | Buy | $20.94 | 23,407 | 490,143 | 2,750,345 | Mar 26, 2018, 06:56 PM |
| TANG KEVIN C | Chief Executive Officer | Mar 01, 2018 | Buy | $27.61 | 4,401 | 121,499 | 12,412,338 | Mar 02, 2018, 05:57 PM |
| TANG KEVIN C | Chief Executive Officer | Feb 28, 2018 | Buy | $27.33 | 9,649 | 263,683 | 12,407,937 | Mar 02, 2018, 05:57 PM |
| TANG KEVIN C | Chief Executive Officer | Feb 27, 2018 | Buy | $27.11 | 12,591 | 341,285 | 12,398,288 | Feb 27, 2018, 04:52 PM |
| TANG KEVIN C | Chief Executive Officer | Feb 26, 2018 | Buy | $27.62 | 13,846 | 382,467 | 12,385,697 | Feb 27, 2018, 04:52 PM |
| TANG KEVIN C | Chief Executive Officer | Feb 23, 2018 | Buy | $27.99 | 2,175 | 60,887 | 12,371,851 | Feb 27, 2018, 04:52 PM |
| TANG KEVIN C | Chief Executive Officer | Feb 20, 2018 | Buy | $25.15 | 8,313 | 209,086 | 12,338,906 | Feb 22, 2018, 06:17 PM |
| TANG KEVIN C | Chief Executive Officer | Feb 22, 2018 | Buy | $27.57 | 17,338 | 478,065 | 12,369,676 | Feb 22, 2018, 06:17 PM |
| TANG KEVIN C | Chief Executive Officer | Feb 21, 2018 | Buy | $27.89 | 13,432 | 374,660 | 12,352,338 | Feb 22, 2018, 06:17 PM |
| TANG KEVIN C | Chief Executive Officer | Feb 16, 2018 | Buy | $24.06 | 57,364 | 1,380,447 | 12,330,593 | Feb 16, 2018, 06:47 PM |
| TANG KEVIN C | Chief Executive Officer | Feb 15, 2018 | Buy | $21.98 | 34,943 | 768,075 | 12,273,229 | Feb 16, 2018, 06:47 PM |
| TANG KEVIN C | Chief Executive Officer | Feb 14, 2018 | Buy | $20.39 | 35,948 | 732,822 | 12,238,286 | Feb 16, 2018, 06:47 PM |
| Vacirca Jeff L | Director | Dec 12, 2017 | Buy | $23.30 | 1,000 | 23,300 | 1,000 | Dec 14, 2017, 08:01 PM |
| Davis Aaron I. | Director | Dec 06, 2017 | Buy | $24.00 | 416,666 | 9,999,984 | 2,726,938 | Dec 08, 2017, 05:21 PM |
| Boxer Capital, LLC | Director | Dec 06, 2017 | Buy | $24.00 | 416,666 | 9,999,984 | 2,726,938 | Dec 08, 2017, 05:19 PM |
| TANG KEVIN C | Chief Executive Officer | Dec 07, 2017 | Buy | $24.00 | 1,291,666 | 30,999,984 | 12,202,338 | Dec 08, 2017, 09:15 AM |
Load More Insider Transactions
Buy
Sale
Option Exercise
| Owner | Relationship | Date | Value($) |
| EcoR1 Capital, LLC | 10% Owner | 12/01/2021 | 308,662 |
| EcoR1 Capital, LLC | 10% Owner | 12/10/2021 | 9,147,420 |
| EcoR1 Capital, LLC | 10% Owner | 12/09/2021 | 284,981 |
| EcoR1 Capital, LLC | 10% Owner | 12/01/2021 | 308,662 |
| Boxer Capital, LLC | 10% Owner | 11/22/2021 | 309,660 |
| Boxer Capital, LLC | 10% Owner | 11/24/2021 | 313,680 |
| Davis Aaron I. | Director | 11/19/2021 | 276,285 |
| Davis Aaron I. | Director | 11/19/2021 | 57,495 |
| Davis Aaron I. | Director | 11/18/2021 | 487,250 |
| Davis Aaron I. | Director | 11/17/2021 | 1,299,240 |
| Davis Aaron I. | Director | 11/17/2021 | 379,678 |
| Boxer Capital, LLC | Director | 11/19/2021 | 276,285 |
| Boxer Capital, LLC | Director | 11/18/2021 | 487,250 |
| Boxer Capital, LLC | Director | 11/17/2021 | 1,299,240 |
| TANG KEVIN C | Chief Executive Officer | 11/19/2021 | 699,930 |
| TANG KEVIN C | Chief Executive Officer | 11/18/2021 | 2,081,879 |
| TANG KEVIN C | Chief Executive Officer | 11/17/2021 | 2,948,747 |
| Hearne Michael S | Chief Financial Officer | 03/15/2021 | 600 |
| O'Connell Joseph P | Chief Medical Officer | 03/15/2021 | 1,606 |
| Hearne Michael S | Chief Financial Officer | 02/26/2021 | 608 |
| O'Connell Joseph P | Chief Medical Officer | 02/26/2021 | 1,610 |
| Hearne Michael S | Chief Financial Officer | 02/12/2021 | 593 |
| O'Connell Joseph P | Chief Medical Officer | 02/12/2021 | 1,610 |
| Hearne Michael S | Chief Financial Officer | 01/29/2021 | 609 |
| O'Connell Joseph P | Chief Medical Officer | 01/29/2021 | 1,610 |
| Hearne Michael S | Chief Financial Officer | 01/15/2021 | 595 |
| O'Connell Joseph P | Chief Medical Officer | 01/15/2021 | 1,597 |
| Hearne Michael S | Chief Financial Officer | 12/31/2020 | 5,712 |
| O'Connell Joseph P | Chief Medical Officer | 12/31/2020 | 2,758 |
| Johnson Craig A | Director | 12/29/2020 | 51,000 |
| Boxer Capital, LLC | Director | 12/30/2020 | 1,746,380 |
| Boxer Capital, LLC | Director | 12/28/2020 | 5,117,048 |
| Davis Aaron I. | Director | 12/29/2020 | 3,849,548 |
| Davis Aaron I. | Director | 12/28/2020 | 1,267,500 |
| Davis Aaron I. | Director | 12/30/2020 | 1,746,380 |
| TANG KEVIN C | Chief Executive Officer | 12/21/2020 | 905,767 |
| TANG KEVIN C | Chief Executive Officer | 12/23/2020 | 2,167,853 |
| TANG KEVIN C | Chief Executive Officer | 12/22/2020 | 1,107,587 |
| Hearne Michael S | Chief Financial Officer | 12/15/2020 | 555 |
| O'Connell Joseph P | Chief Medical Officer | 12/15/2020 | 1,562 |
| Hearne Michael S | Chief Financial Officer | 11/30/2020 | 575 |
| O'Connell Joseph P | Chief Medical Officer | 11/30/2020 | 1,558 |
| Lemkey John G | Chief Operating Officer | 11/30/2020 | 153 |
| Hearne Michael S | Chief Financial Officer | 11/13/2020 | 561 |
| O'Connell Joseph P | Chief Medical Officer | 11/13/2020 | 1,562 |
| Lemkey John G | Chief Operating Officer | 11/13/2020 | 1,171 |
| Hearne Michael S | Chief Financial Officer | 10/30/2020 | 564 |
| O'Connell Joseph P | Chief Medical Officer | 10/30/2020 | 1,556 |
| Lemkey John G | Chief Operating Officer | 10/30/2020 | 1,176 |
| Hearne Michael S | Chief Financial Officer | 10/15/2020 | 561 |
| O'Connell Joseph P | Chief Medical Officer | 10/15/2020 | 1,562 |
| Lemkey John G | Chief Operating Officer | 10/15/2020 | 1,175 |
| Hearne Michael S | Chief Financial Officer | 09/30/2020 | 571 |
| O'Connell Joseph P | Chief Medical Officer | 09/30/2020 | 936 |
| Lemkey John G | Chief Operating Officer | 09/30/2020 | 1,165 |
| Davis Aaron I. | Director | 09/29/2020 | 1,717,760 |
| Davis Aaron I. | Director | 09/28/2020 | 1,214,396 |
| Boxer Capital, LLC | Director | 09/29/2020 | 1,717,760 |
| Boxer Capital, LLC | Director | 09/28/2020 | 1,214,396 |
| TANG KEVIN C | Chief Executive Officer | 09/29/2020 | 150,698 |
| TANG KEVIN C | Chief Executive Officer | 09/28/2020 | 1,305,710 |
| Hearne Michael S | Chief Financial Officer | 09/15/2020 | 562 |
| O'Connell Joseph P | Chief Medical Officer | 09/15/2020 | 940 |
| Lemkey John G | Chief Operating Officer | 09/15/2020 | 1,175 |
| Davis Aaron I. | Director | 09/09/2020 | 1,232,720 |
| Davis Aaron I. | Director | 09/08/2020 | 276,172 |
| Davis Aaron I. | Director | 09/04/2020 | 1,862,739 |
| Boxer Capital, LLC | Director | 09/09/2020 | 1,232,720 |
| Boxer Capital, LLC | Director | 09/08/2020 | 276,172 |
| Boxer Capital, LLC | Director | 09/04/2020 | 1,862,739 |
| Hearne Michael S | Chief Financial Officer | 08/31/2020 | 577 |
| O'Connell Joseph P | Chief Medical Officer | 08/31/2020 | 947 |
| Lemkey John G | Chief Operating Officer | 08/31/2020 | 1,195 |
| Boxer Capital, LLC | Director | 08/28/2020 | 20,000,003 |
| Davis Aaron I. | Director | 08/28/2020 | 20,000,003 |
| TANG KEVIN C | Chief Executive Officer | 08/28/2020 | 14,999,992 |
| Hearne Michael S | Chief Financial Officer | 08/14/2020 | 553 |
| O'Connell Joseph P | Chief Medical Officer | 08/14/2020 | 952 |
| Lemkey John G | Chief Operating Officer | 08/14/2020 | 1,167 |
| Hearne Michael S | Chief Financial Officer | 07/31/2020 | 556 |
| O'Connell Joseph P | Chief Medical Officer | 07/31/2020 | 927 |
| Lemkey John G | Chief Operating Officer | 07/31/2020 | 1,175 |
| Hearne Michael S | Chief Financial Officer | 07/15/2020 | 595 |
| O'Connell Joseph P | Chief Medical Officer | 07/15/2020 | 945 |
| Lemkey John G | Chief Operating Officer | 07/15/2020 | 1,155 |
| Hearne Michael S | Chief Financial Officer | 06/30/2020 | 540 |
| O'Connell Joseph P | Chief Medical Officer | 06/30/2020 | 936 |
| Lemkey John G | Chief Operating Officer | 06/30/2020 | 1,188 |
| Hearne Michael S | Chief Financial Officer | 06/15/2020 | 582 |
| O'Connell Joseph P | Chief Medical Officer | 06/15/2020 | 924 |
| Lemkey John G | Chief Operating Officer | 06/15/2020 | 1,163 |
| Hearne Michael S | Chief Financial Officer | 05/29/2020 | 1,111 |
| O'Connell Joseph P | Chief Medical Officer | 05/29/2020 | 944 |
| Lemkey John G | Chief Operating Officer | 05/29/2020 | 1,166 |
| Hearne Michael S | Chief Financial Officer | 05/15/2020 | 1,128 |
| O'Connell Joseph P | Chief Medical Officer | 05/15/2020 | 936 |
| Lemkey John G | Chief Operating Officer | 05/15/2020 | 1,176 |
| Hearne Michael S | Chief Financial Officer | 04/30/2020 | 1,125 |
| O'Connell Joseph P | Chief Medical Officer | 04/30/2020 | 933 |
| Lemkey John G | Chief Operating Officer | 04/30/2020 | 1,173 |
| Hearne Michael S | Chief Financial Officer | 04/15/2020 | 1,141 |
| O'Connell Joseph P | Chief Medical Officer | 04/15/2020 | 936 |
| Lemkey John G | Chief Operating Officer | 04/15/2020 | 1,164 |
| Hearne Michael S | Chief Financial Officer | 03/31/2020 | 563 |
| O'Connell Joseph P | Chief Medical Officer | 03/31/2020 | 939 |
| Lemkey John G | Chief Operating Officer | 03/31/2020 | 1,173 |
| Hearne Michael S | Chief Financial Officer | 03/13/2020 | 568 |
| O'Connell Joseph P | Chief Medical Officer | 03/13/2020 | 940 |
| Lemkey John G | Chief Operating Officer | 03/13/2020 | 1,175 |
| Hearne Michael S | Chief Financial Officer | 02/28/2020 | 553 |
| O'Connell Joseph P | Chief Medical Officer | 02/28/2020 | 931 |
| Lemkey John G | Chief Operating Officer | 02/28/2020 | 1,182 |
| Hearne Michael S | Chief Financial Officer | 02/14/2020 | 561 |
| O'Connell Joseph P | Chief Medical Officer | 02/14/2020 | 936 |
| Lemkey John G | Chief Operating Officer | 02/14/2020 | 1,149 |
| Hearne Michael S | Chief Financial Officer | 01/31/2020 | 571 |
| O'Connell Joseph P | Chief Medical Officer | 01/31/2020 | 943 |
| Lemkey John G | Chief Operating Officer | 01/31/2020 | 1,191 |
| Hearne Michael S | Chief Financial Officer | 01/15/2020 | 556 |
| O'Connell Joseph P | Chief Medical Officer | 01/15/2020 | 926 |
| Lemkey John G | Chief Operating Officer | 01/15/2020 | 1,157 |
| Hearne Michael S | Chief Financial Officer | 12/31/2019 | 552 |
| O'Connell Joseph P | Chief Medical Officer | 12/31/2019 | 910 |
| Lemkey John G | Chief Operating Officer | 12/31/2019 | 1,131 |
| Hearne Michael S | Chief Financial Officer | 12/13/2019 | 542 |
| O'Connell Joseph P | Chief Medical Officer | 12/13/2019 | 911 |
| Lemkey John G | Chief Operating Officer | 12/13/2019 | 1,157 |
| Hearne Michael S | Chief Financial Officer | 11/29/2019 | 555 |
| O'Connell Joseph P | Chief Medical Officer | 11/29/2019 | 906 |
| Lemkey John G | Chief Operating Officer | 11/29/2019 | 1,140 |
| Hearne Michael S | Chief Financial Officer | 11/15/2019 | 535 |
| O'Connell Joseph P | Chief Medical Officer | 11/15/2019 | 929 |
| Lemkey John G | Chief Operating Officer | 11/15/2019 | 1,126 |
| Hearne Michael S | Chief Financial Officer | 10/31/2019 | 567 |
| O'Connell Joseph P | Chief Medical Officer | 10/31/2019 | 891 |
| Lemkey John G | Chief Operating Officer | 10/31/2019 | 1,134 |
| Hearne Michael S | Chief Financial Officer | 10/15/2019 | 533 |
| O'Connell Joseph P | Chief Medical Officer | 10/15/2019 | 921 |
| Lemkey John G | Chief Operating Officer | 10/15/2019 | 1,139 |
| Hearne Michael S | Chief Financial Officer | 09/30/2019 | 553 |
| O'Connell Joseph P | Chief Medical Officer | 09/30/2019 | 907 |
| Lemkey John G | Chief Operating Officer | 09/30/2019 | 1,129 |
| Hearne Michael S | Chief Financial Officer | 09/13/2019 | 555 |
| O'Connell Joseph P | Chief Medical Officer | 09/13/2019 | 916 |
| Lemkey John G | Chief Operating Officer | 09/13/2019 | 1,157 |
| Hearne Michael S | Chief Financial Officer | 08/30/2019 | 550 |
| O'Connell Joseph P | Chief Medical Officer | 08/30/2019 | 890 |
| Lemkey John G | Chief Operating Officer | 08/30/2019 | 1,126 |
| Hearne Michael S | Chief Financial Officer | 08/15/2019 | 540 |
| O'Connell Joseph P | Chief Medical Officer | 08/15/2019 | 938 |
| Lemkey John G | Chief Operating Officer | 08/15/2019 | 1,137 |
| Hearne Michael S | Chief Financial Officer | 07/31/2019 | 554 |
| O'Connell Joseph P | Chief Medical Officer | 07/31/2019 | 901 |
| Lemkey John G | Chief Operating Officer | 07/31/2019 | 1,143 |
| Hearne Michael S | Chief Financial Officer | 07/15/2019 | 538 |
| O'Connell Joseph P | Chief Medical Officer | 07/15/2019 | 897 |
| Lemkey John G | Chief Operating Officer | 07/15/2019 | 1,136 |
| Hearne Michael S | Chief Financial Officer | 06/28/2019 | 530 |
| O'Connell Joseph P | Chief Medical Officer | 06/28/2019 | 905 |
| Lemkey John G | Chief Operating Officer | 06/28/2019 | 1,123 |
| Boxer Capital, LLC | 10% Owner | 06/26/2019 | 9,999,990 |
| Vacirca Jeff L | Director | 06/26/2019 | 500,006 |
| TANG KEVIN C | Chief Executive Officer | 06/26/2019 | 20,000,006 |
| TANG KEVIN C | Chief Executive Officer | 06/18/2019 | 574,020 |
| TANG KEVIN C | Chief Executive Officer | 06/17/2019 | 269,231 |
| TANG KEVIN C | Chief Executive Officer | 06/14/2019 | 464,294 |
| Hearne Michael S | Chief Financial Officer | 06/14/2019 | 553 |
| O'Connell Joseph P | Chief Medical Officer | 06/14/2019 | 914 |
| Lemkey John G | Chief Operating Officer | 06/14/2019 | 1,148 |
| TANG KEVIN C | Chief Executive Officer | 06/07/2019 | 526,220 |
| TANG KEVIN C | Chief Executive Officer | 06/06/2019 | 1,561,237 |
| TANG KEVIN C | Chief Executive Officer | 06/03/2019 | 343,904 |
| TANG KEVIN C | Chief Executive Officer | 06/05/2019 | 1,020,541 |
| TANG KEVIN C | Chief Executive Officer | 06/04/2019 | 970,772 |
| Hearne Michael S | Chief Financial Officer | 05/31/2019 | 548 |
| O'Connell Joseph P | Chief Medical Officer | 05/31/2019 | 914 |
| Lemkey John G | Chief Operating Officer | 05/31/2019 | 1,133 |
| Hearne Michael S | Chief Financial Officer | 05/15/2019 | 547 |
| O'Connell Joseph P | Chief Medical Officer | 05/15/2019 | 906 |
| Lemkey John G | Chief Operating Officer | 05/15/2019 | 1,132 |
| Hearne Michael S | Chief Financial Officer | 04/30/2019 | 551 |
| O'Connell Joseph P | Chief Medical Officer | 04/30/2019 | 919 |
| Lemkey John G | Chief Operating Officer | 04/30/2019 | 1,153 |
| Hearne Michael S | Chief Financial Officer | 04/15/2019 | 552 |
| O'Connell Joseph P | Chief Medical Officer | 04/15/2019 | 913 |
| Lemkey John G | Chief Operating Officer | 04/15/2019 | 1,126 |
| Hearne Michael S | Chief Financial Officer | 03/29/2019 | 545 |
| O'Connell Joseph P | Chief Medical Officer | 03/29/2019 | 902 |
| Lemkey John G | Chief Operating Officer | 03/29/2019 | 1,146 |
| O'Connell Joseph P | Chief Medical Officer | 03/15/2019 | 909 |
| Hearne Michael S | Chief Financial Officer | 03/15/2019 | 545 |
| Lemkey John G | Chief Operating Officer | 03/15/2019 | 1,131 |
| TANG KEVIN C | Chief Executive Officer | 03/07/2019 | 681,733 |
| TANG KEVIN C | Chief Executive Officer | 03/08/2019 | 1,874,583 |
| Vacirca Jeff L | Director | 03/04/2019 | 51,000 |
| O'Connell Joseph P | Chief Medical Officer | 02/28/2019 | 911 |
| Lemkey John G | Chief Operating Officer | 02/28/2019 | 1,135 |
| Hearne Michael S | Chief Financial Officer | 02/28/2019 | 546 |
| Hearne Michael S | Chief Financial Officer | 02/15/2019 | 548 |
| O'Connell Joseph P | Chief Medical Officer | 02/15/2019 | 913 |
| Lemkey John G | Chief Operating Officer | 02/15/2019 | 1,137 |
| Hearne Michael S | Chief Financial Officer | 01/31/2019 | 535 |
| O'Connell Joseph P | Chief Medical Officer | 01/31/2019 | 901 |
| Lemkey John G | Chief Operating Officer | 01/31/2019 | 1,140 |
| Hearne Michael S | Chief Financial Officer | 01/15/2019 | 554 |
| O'Connell Joseph P | Chief Medical Officer | 01/15/2019 | 914 |
| Lemkey John G | Chief Operating Officer | 01/15/2019 | 1,136 |
| Hearne Michael S | Chief Financial Officer | 12/31/2018 | 539 |
| O'Connell Joseph P | Chief Medical Officer | 12/31/2018 | 886 |
| Lemkey John G | Chief Operating Officer | 12/31/2018 | 838 |
| TANG KEVIN C | Chief Executive Officer | 12/27/2018 | 120,315 |
| TANG KEVIN C | Chief Executive Officer | 12/31/2018 | 460,929 |
| TANG KEVIN C | Chief Executive Officer | 12/28/2018 | 253,863 |
| Davis Aaron I. | Director | 12/26/2018 | 311,815 |
| Davis Aaron I. | Director | 12/21/2018 | 1,347,015 |
| Boxer Capital, LLC | Director | 12/26/2018 | 311,815 |
| Boxer Capital, LLC | Director | 12/21/2018 | 1,347,015 |
| TANG KEVIN C | Chief Executive Officer | 12/20/2018 | 131,742 |
| TANG KEVIN C | Chief Executive Officer | 12/26/2018 | 368,287 |
| TANG KEVIN C | Chief Executive Officer | 12/21/2018 | 255,828 |
| Hearne Michael S | Chief Financial Officer | 12/14/2018 | 540 |
| O'Connell Joseph P | Chief Medical Officer | 12/14/2018 | 874 |
| Lemkey John G | Chief Operating Officer | 12/14/2018 | 822 |
| TANG KEVIN C | Chief Executive Officer | 12/18/2018 | 167,189 |
| TANG KEVIN C | Chief Executive Officer | 12/17/2018 | 268,612 |
| TANG KEVIN C | Chief Executive Officer | 12/14/2018 | 150,838 |
| TANG KEVIN C | Chief Executive Officer | 12/12/2018 | 228,946 |
| TANG KEVIN C | Chief Executive Officer | 12/11/2018 | 83,128 |
| TANG KEVIN C | Chief Executive Officer | 12/07/2018 | 142,291 |
| TANG KEVIN C | Chief Executive Officer | 12/06/2018 | 153,573 |
| Hearne Michael S | Chief Financial Officer | 11/30/2018 | 536 |
| O'Connell Joseph P | Chief Medical Officer | 11/30/2018 | 884 |
| Lemkey John G | Chief Operating Officer | 11/30/2018 | 844 |
| TANG KEVIN C | Chief Executive Officer | 11/27/2018 | 47,912 |
| TANG KEVIN C | Chief Executive Officer | 11/26/2018 | 107,046 |
| TANG KEVIN C | Chief Executive Officer | 11/23/2018 | 70,830 |
| TANG KEVIN C | Chief Executive Officer | 11/21/2018 | 81,141 |
| O'Connell Joseph P | Chief Medical Officer | 11/15/2018 | 885 |
| Lemkey John G | Chief Financial Officer | 11/15/2018 | 828 |
| TANG KEVIN C | Chief Executive Officer | 11/01/2018 | 148,727 |
| O'Connell Joseph P | Chief Medical Officer | 10/31/2018 | 888 |
| Lemkey John G | Chief Financial Officer | 10/31/2018 | 826 |
| TANG KEVIN C | Chief Executive Officer | 10/29/2018 | 149,642 |
| TANG KEVIN C | Chief Executive Officer | 10/26/2018 | 3,725 |
| Davis Aaron I. | Director | 10/24/2018 | 394,753 |
| Boxer Capital, LLC | Director | 10/24/2018 | 394,753 |
| TANG KEVIN C | Chief Executive Officer | 10/25/2018 | 154,059 |
| TANG KEVIN C | Chief Executive Officer | 10/24/2018 | 198,632 |
| TANG KEVIN C | Chief Executive Officer | 10/23/2018 | 257,609 |
| O'Connell Joseph P | Chief Medical Officer | 10/15/2018 | 876 |
| Lemkey John G | Chief Financial Officer | 10/15/2018 | 834 |
| O'Connell Joseph P | Chief Medical Officer | 09/28/2018 | 297 |
| Lemkey John G | Chief Financial Officer | 09/28/2018 | 842 |
| TANG KEVIN C | Chief Executive Officer | 09/28/2018 | 650,378 |
| TANG KEVIN C | Chief Executive Officer | 09/27/2018 | 115,929 |
| TANG KEVIN C | Chief Executive Officer | 09/26/2018 | 190,664 |
| TANG KEVIN C | Chief Executive Officer | 09/25/2018 | 196,477 |
| TANG KEVIN C | Chief Executive Officer | 09/24/2018 | 402,832 |
| TANG KEVIN C | Chief Executive Officer | 09/20/2018 | 562,736 |
| TANG KEVIN C | Chief Executive Officer | 09/19/2018 | 232,374 |
| TANG KEVIN C | Chief Executive Officer | 09/18/2018 | 964,186 |
| O'Connell Joseph P | Chief Medical Officer | 09/14/2018 | 293 |
| Lemkey John G | Chief Financial Officer | 09/14/2018 | 829 |
| O'Connell Joseph P | Chief Medical Officer | 08/31/2018 | 294 |
| Lemkey John G | Chief Financial Officer | 08/31/2018 | 832 |
| TANG KEVIN C | Chief Executive Officer | 08/21/2018 | 146,151 |
| TANG KEVIN C | Chief Executive Officer | 08/20/2018 | 191,613 |
| TANG KEVIN C | Chief Executive Officer | 08/17/2018 | 45,980 |
| TANG KEVIN C | Chief Executive Officer | 08/16/2018 | 730,681 |
| O'Connell Joseph P | Chief Medical Officer | 08/15/2018 | 303 |
| Lemkey John G | Chief Financial Officer | 08/15/2018 | 844 |
| TANG KEVIN C | Chief Executive Officer | 08/15/2018 | 179,242 |
| TANG KEVIN C | Chief Executive Officer | 08/14/2018 | 125,352 |
| TANG KEVIN C | Chief Executive Officer | 08/13/2018 | 127,111 |
| O'Connell Joseph P | Chief Medical Officer | 07/31/2018 | 286 |
| Lemkey John G | Chief Financial Officer | 07/31/2018 | 823 |
| O'Connell Joseph P | Chief Medical Officer | 07/13/2018 | 305 |
| Lemkey John G | Chief Financial Officer | 07/13/2018 | 835 |
| O'Connell Joseph P | Chief Medical Officer | 06/29/2018 | 300 |
| Lemkey John G | Chief Financial Officer | 06/29/2018 | 845 |
| O'Connell Joseph P | Chief Medical Officer | 06/15/2018 | 293 |
| Lemkey John G | Chief Financial Officer | 06/15/2018 | 834 |
| O'Connell Joseph P | Chief Medical Officer | 05/31/2018 | 285 |
| Lemkey John G | Chief Financial Officer | 05/31/2018 | 816 |
| O'Connell Joseph P | Chief Medical Officer | 05/15/2018 | 295 |
| Lemkey John G | Chief Financial Officer | 05/15/2018 | 847 |
| O'Connell Joseph P | Chief Medical Officer | 04/30/2018 | 305 |
| Lemkey John G | Chief Financial Officer | 04/30/2018 | 824 |
| O'Connell Joseph P | Chief Medical Officer | 04/13/2018 | 276 |
| Lemkey John G | Chief Financial Officer | 04/13/2018 | 828 |
| Boxer Capital, LLC | Director | 03/26/2018 | 754,096 |
| Boxer Capital, LLC | Director | 03/23/2018 | 1,028,914 |
| Boxer Capital, LLC | Director | 03/22/2018 | 490,143 |
| Davis Aaron I. | Director | 03/26/2018 | 754,096 |
| Davis Aaron I. | Director | 03/23/2018 | 1,028,914 |
| Davis Aaron I. | Director | 03/22/2018 | 490,143 |
| TANG KEVIN C | Chief Executive Officer | 03/01/2018 | 121,499 |
| TANG KEVIN C | Chief Executive Officer | 02/28/2018 | 263,683 |
| TANG KEVIN C | Chief Executive Officer | 02/27/2018 | 341,285 |
| TANG KEVIN C | Chief Executive Officer | 02/26/2018 | 382,467 |
| TANG KEVIN C | Chief Executive Officer | 02/23/2018 | 60,887 |
| TANG KEVIN C | Chief Executive Officer | 02/20/2018 | 209,086 |
| TANG KEVIN C | Chief Executive Officer | 02/22/2018 | 478,065 |
| TANG KEVIN C | Chief Executive Officer | 02/21/2018 | 374,660 |
| TANG KEVIN C | Chief Executive Officer | 02/16/2018 | 1,380,447 |
| TANG KEVIN C | Chief Executive Officer | 02/15/2018 | 768,075 |
| TANG KEVIN C | Chief Executive Officer | 02/14/2018 | 732,822 |
| Vacirca Jeff L | Director | 12/12/2017 | 23,300 |
| Davis Aaron I. | Director | 12/06/2017 | 9,999,984 |
| Boxer Capital, LLC | Director | 12/06/2017 | 9,999,984 |
| TANG KEVIN C | Chief Executive Officer | 12/07/2017 | 30,999,984 |
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