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As of 12/31/69 07:00 PM EST. Market closed.
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As of 12/31/69 07:00 PM EST. Market closed.
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INSIDER TRANSACTIONS FOR
| Owner | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| Rickey James Paul | See Remarks | Nov 30, 2023 | Option Exercise | $3.23 | 700 | 2,261 | 700 | Dec 01, 2023, 05:00 PM |
| Rickey James Paul | See Remarks | Nov 30, 2023 | Sale | $16.00 | 700 | 11,200 | 0 | Dec 01, 2023, 05:00 PM |
| Decheng Capital Global Healthcare Fund (Master), LP | 10% Owner | Nov 09, 2023 | Buy | $12.50 | 375,000 | 4,687,500 | 1,735,544 | Nov 14, 2023, 05:36 PM |
| Cui Xiangmin | Director | Nov 09, 2023 | Buy | $12.50 | 375,000 | 4,687,500 | 1,735,544 | Nov 14, 2023, 05:33 PM |
| Rickey James Paul | See Remarks | Nov 06, 2023 | Option Exercise | $3.23 | 10,989 | 35,494 | 18,003 | Nov 08, 2023, 05:20 PM |
| Rickey James Paul | See Remarks | Nov 06, 2023 | Sale | $16.03 | 18,003 | 288,554 | 0 | Nov 08, 2023, 05:20 PM |
| Cui Xiangmin | Director | Sep 23, 2022 | Option Exercise | $7.35 | 2,000,000 | 14,700,000 | 5,347,744 | Sep 27, 2022, 04:51 PM |
| Decheng Capital China Life Sciences USD Fund III, L.P. | 10% Owner | Sep 23, 2022 | Option Exercise | $7.35 | 1,360,544 | 9,999,998 | 1,360,544 | Sep 27, 2022, 04:46 PM |
| Decheng Capital China Life Sciences USD Fund III, L.P. | 10% Owner | Sep 23, 2022 | Option Exercise | $7.35 | 639,456 | 4,700,002 | 5,347,744 | Sep 27, 2022, 04:46 PM |
| Venkatesan Jay | Director | Jul 15, 2022 | Option Exercise | $0.45 | 20,063 | 9,028 | 238,126 | Jul 19, 2022, 04:38 PM |
| Frazier Life Sciences VIII, L.P. | 10% Owner | Feb 11, 2022 | Buy | $7.10 | 112,665 | 799,989 | 1,484,115 | Feb 15, 2022, 05:00 PM |
| Peetz Christopher | Director | Sep 23, 2021 | Buy | $10.17 | 1,900 | 19,323 | 1,900 | Sep 27, 2021, 07:03 AM |
| CONWAY ROBERT E | Director | Sep 23, 2021 | Buy | $10.08 | 15,000 | 151,153 | 50,000 | Sep 27, 2021, 07:02 AM |
| CONWAY ROBERT E | Director | Sep 23, 2021 | Sale | $10.08 | 15,000 | 151,153 | 50,000 | Sep 24, 2021, 06:39 PM |
| Peetz Christopher | Director | Sep 23, 2021 | Sale | $10.17 | 1,900 | 19,323 | 1,900 | Sep 24, 2021, 05:32 PM |
| CONWAY ROBERT E | Director | Sep 21, 2021 | Buy | $9.80 | 10,000 | 97,966 | 35,000 | Sep 23, 2021, 08:31 PM |
| ORBIMED ADVISORS LLC | Director | Sep 17, 2021 | Buy | $9.40 | 1,010,637 | 9,499,987 | 3,656,061 | Sep 21, 2021, 06:42 PM |
| Decheng Capital China Life Sciences USD Fund III, L.P. | 10% Owner | Sep 17, 2021 | Buy | $9.40 | 1,542,553 | 14,499,998 | 4,708,288 | Sep 21, 2021, 06:39 PM |
| Thompson Peter A. | Director | Sep 17, 2021 | Buy | $9.40 | 1,010,637 | 9,499,987 | 3,656,061 | Sep 21, 2021, 06:38 PM |
| Alpine ImmunoSciences, L.P. | 10% Owner | Sep 17, 2021 | Sale | $9.40 | 400,000 | 3,760,000 | 2,600,980 | Sep 21, 2021, 05:18 PM |
| GOLD MITCHELL | Executive Chairman and CEO | Sep 17, 2021 | Sale | $10.01 | 45,262 | 452,964 | 109,387 | Sep 21, 2021, 05:16 PM |
| GOLD MITCHELL | Executive Chairman and CEO | Sep 17, 2021 | Sale | $9.40 | 400,000 | 3,760,000 | 2,600,980 | Sep 21, 2021, 05:16 PM |
| Venkatesan Jay | Director | Sep 17, 2021 | Sale | $9.40 | 400,000 | 3,760,000 | 2,600,980 | Sep 21, 2021, 05:14 PM |
| Cui Xiangmin | Director | Sep 17, 2021 | Buy | $9.40 | 1,542,553 | 14,499,998 | 4,708,288 | Sep 21, 2021, 05:12 PM |
| GOLD MITCHELL | Executive Chairman and CEO | Sep 16, 2021 | Sale | $10.00 | 6,768 | 67,696 | 154,649 | Sep 17, 2021, 06:06 PM |
| GOLD MITCHELL | Executive Chairman and CEO | Sep 15, 2021 | Sale | $10.00 | 3,484 | 34,840 | 161,417 | Sep 17, 2021, 06:06 PM |
| GOLD MITCHELL | Executive Chairman and CEO | Jun 28, 2021 | Sale | $10.00 | 3,479 | 34,792 | 164,901 | Jun 29, 2021, 05:13 PM |
| GOLD MITCHELL | Executive Chairman and CEO | Jun 25, 2021 | Sale | $10.01 | 9,473 | 94,865 | 168,380 | Jun 29, 2021, 05:13 PM |
| GOLD MITCHELL | Executive Chairman and CEO | May 20, 2021 | Sale | $15.00 | 1,221 | 18,316 | 177,853 | May 21, 2021, 05:16 PM |
| GOLD MITCHELL | Executive Chairman and CEO | May 19, 2021 | Sale | $15.03 | 50,965 | 765,917 | 179,074 | May 21, 2021, 05:16 PM |
| Venkatesan Jay | Director | Mar 30, 2021 | Option Exercise | $4.09 | 7,650 | 31,289 | 210,413 | Apr 23, 2021, 06:14 PM |
| Venkatesan Jay | Director | Mar 31, 2021 | Option Exercise | $3.62 | 7,650 | 27,718 | 218,063 | Apr 23, 2021, 06:14 PM |
| GOLD MITCHELL | Executive Chairman and CEO | Apr 14, 2021 | Sale | $10.52 | 10,000 | 105,200 | 250,039 | Apr 15, 2021, 06:09 PM |
| GOLD MITCHELL | Executive Chairman and CEO | Apr 13, 2021 | Sale | $10.07 | 10,000 | 100,714 | 260,039 | Apr 15, 2021, 06:09 PM |
| GOLD MITCHELL | Executive Chairman and CEO | Mar 05, 2021 | Sale | $12.99 | 10,000 | 129,875 | 270,039 | Mar 08, 2021, 05:01 PM |
| GOLD MITCHELL | Executive Chairman and CEO | Mar 04, 2021 | Sale | $13.01 | 10,000 | 130,108 | 280,039 | Mar 08, 2021, 05:01 PM |
| GOLD MITCHELL | Executive Chairman and CEO | Feb 01, 2021 | Sale | $12.87 | 10,000 | 128,665 | 307,060 | Feb 03, 2021, 05:01 PM |
| GOLD MITCHELL | Executive Chairman and CEO | Feb 02, 2021 | Sale | $11.74 | 10,000 | 117,381 | 290,039 | Feb 03, 2021, 05:01 PM |
| PENG STANFORD L | See Remarks | Dec 31, 2020 | Option Exercise | $12.60 | 3,923 | 49,430 | 24,371 | Jan 04, 2021, 08:41 PM |
| GOLD MITCHELL | Executive Chairman and CEO | Dec 31, 2020 | Option Exercise | $12.60 | 11,123 | 140,150 | 310,039 | Jan 04, 2021, 08:37 PM |
| Rickey James Paul | Senior VP and CFO | Dec 31, 2020 | Option Exercise | $12.60 | 2,258 | 28,451 | 24,027 | Jan 04, 2021, 08:31 PM |
| ORBIMED ADVISORS LLC | Director | Dec 28, 2020 | Sale | $14.25 | 600,000 | 8,550,000 | 3,070,955 | Dec 30, 2020, 04:44 PM |
| Thompson Peter A. | Director | Dec 28, 2020 | Sale | $14.25 | 600,000 | 8,550,000 | 3,070,955 | Dec 30, 2020, 04:38 PM |
| CONWAY ROBERT E | Director | Nov 19, 2020 | Buy | $8.03 | 10,000 | 80,300 | 25,000 | Nov 23, 2020, 05:00 PM |
| Rickey James Paul | Senior VP and CFO | Jun 30, 2020 | Option Exercise | $9.71 | 2,258 | 21,925 | 26,285 | Jul 01, 2020, 07:38 PM |
| GOLD MITCHELL | Executive Chairman and CEO | Jun 30, 2020 | Option Exercise | $9.71 | 8,227 | 79,884 | 60,634 | Jul 01, 2020, 07:24 PM |
| PENG STANFORD L | See Remarks | Jun 30, 2020 | Option Exercise | $9.71 | 3,923 | 38,092 | 28,294 | Jul 01, 2020, 07:24 PM |
| Rickey James Paul | Senior VP and CFO | May 30, 2019 | Buy | $4.95 | 10,000 | 49,500 | 10,000 | Jun 03, 2019, 08:00 AM |
| TIGER MANAGEMENT L.L.C. | 10% Owner | Feb 08, 2019 | Sale | $5.85 | 25,000 | 146,245 | 137,728 | Feb 12, 2019, 01:52 PM |
| Cui Xiangmin | Director | Jan 18, 2019 | Option Exercise | $5.37 | 3,165,735 | 16,999,997 | 3,165,735 | Jan 23, 2019, 08:48 PM |
| Thompson Peter A. | Director | Jan 18, 2019 | Buy | $5.37 | 372,439 | 1,999,997 | 3,670,955 | Jan 23, 2019, 06:01 PM |
| ORBIMED ADVISORS LLC | Director | Jan 18, 2019 | Buy | $5.37 | 372,439 | 1,999,997 | 3,670,955 | Jan 23, 2019, 05:58 PM |
| Alpine ImmunoSciences, L.P. | 10% Owner | Jan 18, 2019 | Buy | $5.37 | 190,875 | 1,024,999 | 3,994,781 | Jan 22, 2019, 08:46 PM |
| GOLD MITCHELL | Executive Chairman and CEO | Jan 18, 2019 | Buy | $5.37 | 190,875 | 1,024,999 | 3,994,781 | Jan 22, 2019, 08:44 PM |
| Venkatesan Jay | Director | Jan 18, 2019 | Buy | $5.37 | 190,875 | 1,024,999 | 3,994,781 | Jan 22, 2019, 08:44 PM |
| Frazier Life Sciences VIII, L.P. | 10% Owner | Jan 18, 2019 | Buy | $5.37 | 372,439 | 1,999,997 | 2,571,450 | Jan 22, 2019, 05:14 PM |
| Topper James N | Director | Jan 18, 2019 | Buy | $5.37 | 372,439 | 1,999,997 | 2,571,450 | Jan 22, 2019, 05:09 PM |
| BVF PARTNERS L P/IL | 10% Owner | Jun 20, 2017 | Buy | $2.25 | 17,806 | 40,064 | 1,109,258 | Jun 22, 2017, 05:08 PM |
| BVF PARTNERS L P/IL | 10% Owner | Jun 07, 2017 | Buy | $2.28 | 36,900 | 84,180 | 1,099,526 | Jun 07, 2017, 06:21 PM |
| BVF PARTNERS L P/IL | 10% Owner | Jun 05, 2017 | Buy | $2.29 | 35,750 | 81,889 | 1,079,345 | Jun 07, 2017, 06:21 PM |
| BVF PARTNERS L P/IL | 10% Owner | May 31, 2017 | Buy | $2.25 | 28,100 | 63,141 | 1,060,139 | Jun 01, 2017, 05:11 PM |
| BVF PARTNERS L P/IL | 10% Owner | May 30, 2017 | Buy | $2.30 | 18,900 | 43,389 | 1,044,789 | Jun 01, 2017, 05:11 PM |
| BVF PARTNERS L P/IL | 10% Owner | May 18, 2017 | Buy | $2.30 | 29,886 | 68,732 | 1,028,344 | May 19, 2017, 06:21 PM |
| BVF PARTNERS L P/IL | 10% Owner | May 17, 2017 | Buy | $2.30 | 37,372 | 85,907 | 1,011,908 | May 19, 2017, 06:21 PM |
| BVF PARTNERS L P/IL | 10% Owner | May 19, 2017 | Buy | $2.30 | 11,600 | 26,680 | 1,034,597 | May 19, 2017, 06:21 PM |
| BVF PARTNERS L P/IL | 10% Owner | May 11, 2017 | Buy | $2.34 | 7,034 | 16,480 | 986,943 | May 11, 2017, 06:52 PM |
| BVF PARTNERS L P/IL | 10% Owner | May 10, 2017 | Buy | $2.35 | 62,000 | 145,433 | 983,149 | May 11, 2017, 06:52 PM |
| BVF PARTNERS L P/IL | 10% Owner | May 09, 2017 | Buy | $2.29 | 40,000 | 91,516 | 949,458 | May 11, 2017, 06:52 PM |
| CONWAY ROBERT E | Director | May 08, 2017 | Buy | $2.28 | 15,000 | 34,200 | 60,000 | May 11, 2017, 12:17 PM |
| CONWAY ROBERT E | Director | May 09, 2017 | Buy | $2.34 | 5,000 | 11,700 | 45,000 | May 10, 2017, 02:00 PM |
| TROHA JANICE | Exec Vice President / COO | May 05, 2017 | Buy | $2.34 | 10,000 | 23,400 | 10,000 | May 09, 2017, 02:01 PM |
| CONWAY ROBERT E | Director | May 05, 2017 | Buy | $2.30 | 20,000 | 46,000 | 40,000 | May 09, 2017, 02:01 PM |
| CONWAY ROBERT E | Director | May 04, 2017 | Buy | $2.26 | 10,000 | 22,600 | 20,000 | May 08, 2017, 02:00 PM |
| Rodman David Malcom | Exec Vice President and CMO | Jan 04, 2017 | Sale | $2.27 | 6,687 | 15,179 | 11,368 | Jan 05, 2017, 11:00 AM |
| Carruthers R Michael | Exec Vice President / CFO | Dec 02, 2016 | Buy | $2.09 | 24,000 | 50,256 | 24,000 | Dec 05, 2016, 04:26 PM |
| Rodman David Malcom | Exec Vice President and CMO | Oct 04, 2016 | Sale | $7.96 | 5,820 | 46,327 | 12,236 | Oct 05, 2016, 04:16 PM |
| Rodman David Malcom | Exec Vice President and CMO | Jul 05, 2016 | Sale | $4.66 | 5,950 | 27,727 | 12,105 | Jul 06, 2016, 04:15 PM |
| Congleton Jon | President and CEO | Jun 16, 2016 | Buy | $3.87 | 5,000 | 19,345 | 20,000 | Jun 17, 2016, 10:51 AM |
| Congleton Jon | President and CEO | Mar 24, 2016 | Buy | $4.22 | 5,000 | 21,084 | 15,000 | Mar 25, 2016, 11:21 AM |
| Congleton Jon | President and CEO | Mar 22, 2016 | Buy | $4.38 | 5,000 | 21,907 | 10,000 | Mar 23, 2016, 04:31 PM |
| Congleton Jon | President and CEO | Dec 11, 2015 | Buy | $8.10 | 5,000 | 40,500 | 5,000 | Dec 14, 2015, 12:50 PM |
| CONWAY ROBERT E | Director | Dec 09, 2015 | Buy | $8.10 | 10,000 | 81,000 | 10,000 | Dec 11, 2015, 09:01 AM |
| Flynn James E | 10% Owner | Jun 23, 2015 | Buy | $14.00 | 77,539 | 1,085,546 | 832,216 | Jun 25, 2015, 03:14 PM |
| Flynn James E | 10% Owner | Jun 23, 2015 | Buy | $14.00 | 67,666 | 947,324 | 726,242 | Jun 25, 2015, 03:14 PM |
| Flynn James E | 10% Owner | Jun 23, 2015 | Buy | $14.00 | 104,795 | 1,467,130 | 1,124,740 | Jun 25, 2015, 03:14 PM |
| Rock Springs Capital Management LP | 10% Owner | Jun 22, 2015 | Buy | $14.00 | 200,000 | 2,800,000 | 564,358 | Jun 24, 2015, 04:09 PM |
| Hawkes Bay Master Investors (Cayman) L.P. | 10% Owner | Jun 19, 2015 | Buy | $14.67 | 11,700 | 171,591 | 32,100 | Jun 23, 2015, 02:11 PM |
| Hawkes Bay Master Investors (Cayman) L.P. | 10% Owner | Jun 22, 2015 | Buy | $14.75 | 5,500 | 81,113 | 37,600 | Jun 23, 2015, 02:11 PM |
| Jennison Global Healthcare Master Fund, Ltd. | 10% Owner | Jun 22, 2015 | Option Exercise | $14.00 | 303,631 | 4,250,834 | 329,780 | Jun 22, 2015, 06:26 PM |
| Jennison Global Healthcare Master Fund, Ltd. | 10% Owner | Jun 17, 2015 | Buy | $14.00 | 26,149 | 366,086 | 26,149 | Jun 19, 2015, 04:55 PM |
| Hawkes Bay Master Investors (Cayman) L.P. | 10% Owner | Jun 18, 2015 | Buy | $14.75 | 6,200 | 91,450 | 20,400 | Jun 19, 2015, 01:13 PM |
| Hawkes Bay Master Investors (Cayman) L.P. | 10% Owner | Jun 17, 2015 | Buy | $14.35 | 14,200 | 203,825 | 14,200 | Jun 19, 2015, 01:13 PM |
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