Ligand Pharmaceuticals, Inc.. (LGND) NASDAQ
$68.76 1.13 (1.67%)
Market Cap: $1.15B
As of 03/23/23 04:00 PM EDT. Market closed.
Ligand Pharmaceuticals, Inc.. (LGND)
NASDAQ
$68.76
1.13 (1.67%)
Market Cap: $1.15B
As of 03/23/23 04:00 PM EDT. Market closed.
Ligand Pharmaceuticals is a biopharmaceutical company located in San Diego, California. Founded in 1987 as Progenx Inc., the company went public in ... read more
Ligand Pharmaceuticals is a biopharmaceutical company located in San Diego, California. Founded in 1987 as Progenx Inc., the company went public in 1992. read less
COMPANY PROFILE
Sector
Manufacturing
Industry
Pharmaceutical Preparation Manufacturing
CEO
John Higgins
Full Time Employees
154
CEO Compensation (Base)
$627,413
CEO Compensation (Total)
$6.31M
Sector
Manufacturing
Industry
Pharmaceutical Preparation Manufacturing
CEO
John Higgins
Full Time Employees
154
CEO Compensation (Base)
$627,413
CEO Compensation (Total)
$6.31M
URL
Address
3911 Sorrento Valley Blvd Ste 110, California, San Diego, 92121-1402.
PRICE CHART FOR LIGAND PHARMACEUTICALS, INC.
From:
To:
NEWS
KEY STATS
Open
$68.38
Previous Close
$67.63
Days Range
$67.67 - $69.98
52 week range
$60.12 - $121.66
Volume
109,136
Avg. Volume (30 days)
147,551
Market Cap
$1.15B
Dividend Yield
0.00%
P/E
-34.62
Shares Outstanding
17,076,658
Open
$68.38
Previous Close
$67.63
Days Range
$67.67 - $69.98
52 week range
$60.12 - $121.66
Volume
109,136
Avg. Volume (30 days)
147,551
Market Cap
$1.15B
Dividend Yield
0.00%
P/E
-34.62
Shares Outstanding
17,076,658
Open in: 
Open in:
INSIDER TRANSACTIONS FOR LIGAND PHARMACEUTICALS, INC.
| Owner | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| Korenberg Matthew E | President & COO | Feb 15, 2023 | Option Exercise | $72.98 | 2,890 | 210,912 | 89,679 | Feb 17, 2023, 07:23 PM |
| Espinoza Octavio | Chief Financial Officer | Feb 15, 2023 | Option Exercise | $72.98 | 849 | 61,960 | 18,096 | Feb 17, 2023, 07:20 PM |
| Espinoza Octavio | Chief Financial Officer | Dec 30, 2022 | Option Exercise | $56.78 | 275 | 15,614 | 18,945 | Jan 04, 2023, 05:00 PM |
| Korenberg Matthew E | President & COO | Dec 28, 2022 | Option Exercise | $66.29 | 3,859 | 255,813 | 92,569 | Dec 30, 2022, 05:00 PM |
| HIGGINS JOHN L | Director | Dec 28, 2022 | Option Exercise | $66.29 | 5,289 | 350,608 | 417,695 | Dec 30, 2022, 05:00 PM |
| HIGGINS JOHN L | Director | Dec 16, 2022 | Sale | $61.87 | 10,000 | 618,657 | 422,984 | Dec 20, 2022, 06:36 PM |
| HIGGINS JOHN L | Director | Dec 12, 2022 | Option Exercise | $64.80 | 3,944 | 255,571 | 432,984 | Dec 14, 2022, 05:00 PM |
| HIGGINS JOHN L | Director | Dec 12, 2022 | Option Exercise | $12.78 | 20,000 | 255,600 | 436,928 | Dec 14, 2022, 05:00 PM |
| Korenberg Matthew E | President & COO | Nov 30, 2022 | Option Exercise | $72.90 | 3,593 | 261,930 | 82,428 | Dec 01, 2022, 09:42 PM |
| HIGGINS JOHN L | Chief Executive Officer | Nov 30, 2022 | Option Exercise | $72.90 | 9,803 | 714,639 | 416,928 | Dec 01, 2022, 09:42 PM |
| Espinoza Octavio | Chief Financial Officer | Nov 30, 2022 | Option Exercise | $72.90 | 1,187 | 86,532 | 7,670 | Dec 01, 2022, 09:41 PM |
| Reardon Andrew | See Remarks | Nov 30, 2022 | Option Exercise | $72.90 | 1,073 | 78,222 | 10,940 | Dec 01, 2022, 09:39 PM |
| HIGGINS JOHN L | Chief Executive Officer | Nov 18, 2022 | Option Exercise | $12.78 | 10,000 | 127,800 | 426,731 | Nov 21, 2022, 07:04 PM |
| HIGGINS JOHN L | Chief Executive Officer | Nov 17, 2022 | Sale | $78.32 | 10,000 | 783,173 | 416,731 | Nov 21, 2022, 07:04 PM |
| Espinoza Octavio | Chief Financial Officer | Nov 09, 2022 | Sale | $75.64 | 1,696 | 128,283 | 8,857 | Nov 10, 2022, 04:30 PM |
| HIGGINS JOHN L | Chief Executive Officer | Sep 16, 2022 | Sale | $88.06 | 1,000 | 88,060 | 366,180 | Sep 22, 2022, 08:32 PM |
| HIGGINS JOHN L | Chief Executive Officer | Sep 16, 2022 | Sale | $89.35 | 3,000 | 268,050 | 364,180 | Sep 16, 2022, 07:49 PM |
| HIGGINS JOHN L | Chief Executive Officer | Sep 15, 2022 | Sale | $90.00 | 2,000 | 180,000 | 367,180 | Sep 16, 2022, 07:49 PM |
| Korenberg Matthew E | EVP,Finance & Strategy and CFO | Jun 30, 2022 | Option Exercise | $75.84 | 164 | 12,437 | 52,532 | Jul 06, 2022, 08:00 PM |
| HIGGINS JOHN L | Chief Executive Officer | Jun 30, 2022 | Option Exercise | $75.84 | 164 | 12,437 | 369,180 | Jul 06, 2022, 08:00 PM |
| FOEHR MATTHEW W | President and COO | May 13, 2022 | Buy | $82.76 | 2,500 | 206,910 | 173,354 | May 13, 2022, 07:05 PM |
| HIGGINS JOHN L | Chief Executive Officer | May 09, 2022 | Option Exercise | $21.92 | 8,000 | 175,360 | 348,593 | May 10, 2022, 05:33 PM |
| FOEHR MATTHEW W | President and COO | Feb 15, 2022 | Option Exercise | $123.68 | 3,546 | 438,569 | 173,166 | Feb 16, 2022, 08:24 PM |
| HIGGINS JOHN L | Chief Executive Officer | Feb 15, 2022 | Option Exercise | $123.68 | 5,923 | 732,557 | 344,570 | Feb 16, 2022, 08:23 PM |
| Korenberg Matthew E | EVP,Finance & Strategy and CFO | Feb 15, 2022 | Option Exercise | $123.68 | 3,407 | 421,378 | 46,807 | Feb 16, 2022, 08:23 PM |
| Korenberg Matthew E | EVP,Finance & Strategy and CFO | Jan 26, 2022 | Option Exercise | $113.68 | 3,628 | 412,431 | 50,022 | Jan 28, 2022, 08:43 PM |
| HIGGINS JOHN L | Chief Executive Officer | Jan 26, 2022 | Option Exercise | $113.68 | 9,243 | 1,050,744 | 355,201 | Jan 28, 2022, 08:42 PM |
| Berkman Charles S | SVP, Gen. Counsel & Secretary | Jan 26, 2022 | Option Exercise | $113.68 | 2,156 | 245,094 | 33,298 | Jan 28, 2022, 08:42 PM |
| FOEHR MATTHEW W | President and COO | Jan 26, 2022 | Option Exercise | $113.68 | 5,125 | 582,610 | 177,588 | Jan 28, 2022, 08:41 PM |
| LAMATTINA JOHN L | Director | Nov 16, 2021 | Option Exercise | $32.30 | 4,835 | 156,170 | 30,233 | Nov 17, 2021, 05:06 PM |
| LAMATTINA JOHN L | Director | Nov 16, 2021 | Sale | $161.86 | 4,835 | 782,579 | 25,398 | Nov 17, 2021, 05:06 PM |
| HIGGINS JOHN L | Chief Executive Officer | Nov 12, 2021 | Sale | $160.50 | 3,000 | 481,500 | 335,095 | Nov 12, 2021, 07:31 PM |
| FOEHR MATTHEW W | President and COO | Nov 11, 2021 | Option Exercise | $28.54 | 12,188 | 347,818 | 177,685 | Nov 12, 2021, 04:54 PM |
| FOEHR MATTHEW W | President and COO | Nov 11, 2021 | Sale | $163.02 | 11,160 | 1,819,259 | 166,525 | Nov 12, 2021, 04:54 PM |
| FOEHR MATTHEW W | President and COO | Aug 04, 2021 | Option Exercise | $29.23 | 9,982 | 291,745 | 173,195 | Aug 05, 2021, 04:44 PM |
| FOEHR MATTHEW W | President and COO | Aug 04, 2021 | Sale | $109.67 | 8,840 | 969,509 | 164,355 | Aug 05, 2021, 04:44 PM |
| HIGGINS JOHN L | Chief Executive Officer | Jun 30, 2021 | Option Exercise | $85.91 | 247 | 21,220 | 338,095 | Jul 02, 2021, 05:14 PM |
| Korenberg Matthew E | EVP,Finance & Strategy and CFO | Jun 30, 2021 | Option Exercise | $85.91 | 247 | 21,220 | 39,690 | Jul 02, 2021, 05:13 PM |
| KOZARICH JOHN W | Director | May 11, 2021 | Option Exercise | $128.56 | 391 | 50,267 | 34,152 | May 13, 2021, 08:57 PM |
| KOZARICH JOHN W | Director | May 11, 2021 | Option Exercise | $10.12 | 4,835 | 48,930 | 34,543 | May 13, 2021, 08:57 PM |
| KOZARICH JOHN W | Director | Feb 22, 2021 | Option Exercise | $10.12 | 2,500 | 25,300 | 29,708 | Feb 23, 2021, 05:18 PM |
| Berkman Charles S | SVP, Gen. Counsel & Secretary | Feb 15, 2021 | Option Exercise | $172.46 | 1,015 | 175,047 | 28,701 | Feb 18, 2021, 06:28 PM |
| FOEHR MATTHEW W | President and COO | Feb 15, 2021 | Option Exercise | $172.46 | 3,098 | 534,281 | 167,557 | Feb 18, 2021, 06:28 PM |
| HIGGINS JOHN L | Chief Executive Officer | Feb 15, 2021 | Option Exercise | $172.46 | 5,212 | 898,862 | 341,856 | Feb 18, 2021, 06:27 PM |
| Korenberg Matthew E | EVP,Finance & Strategy and CFO | Feb 15, 2021 | Option Exercise | $172.46 | 2,309 | 398,210 | 41,318 | Feb 18, 2021, 06:27 PM |
| Davis Todd C | Director | Feb 11, 2021 | Option Exercise | $195.91 | 2,474 | 484,681 | 50,152 | Feb 12, 2021, 06:23 PM |
| Davis Todd C | Director | Feb 10, 2021 | Sale | $213.14 | 5,083 | 1,083,411 | 47,678 | Feb 12, 2021, 06:23 PM |
| Sabba Stephen L | Director | Feb 09, 2021 | Option Exercise | $11.32 | 14,670 | 166,138 | 39,101 | Feb 11, 2021, 04:06 PM |
| Sabba Stephen L | Director | Feb 09, 2021 | Sale | $208.53 | 14,670 | 3,059,123 | 38,545 | Feb 11, 2021, 04:06 PM |
| HIGGINS JOHN L | Chief Executive Officer | Feb 05, 2021 | Option Exercise | $203.03 | 2,970 | 602,999 | 343,060 | Feb 09, 2021, 06:08 PM |
| HIGGINS JOHN L | Chief Executive Officer | Feb 05, 2021 | Option Exercise | $12.16 | 114,666 | 1,394,017 | 346,030 | Feb 09, 2021, 06:08 PM |
| HIGGINS JOHN L | Chief Executive Officer | Feb 05, 2021 | Sale | $203.40 | 54,666 | 11,119,228 | 286,030 | Feb 09, 2021, 06:08 PM |
| Berkman Charles S | SVP, Gen. Counsel & Secretary | Feb 04, 2021 | Sale | $178.50 | 18,097 | 3,230,369 | 28,906 | Feb 05, 2021, 05:03 PM |
| FOEHR MATTHEW W | President and COO | Feb 04, 2021 | Option Exercise | $23.07 | 45,547 | 1,050,890 | 212,745 | Feb 05, 2021, 05:03 PM |
| FOEHR MATTHEW W | President and COO | Feb 04, 2021 | Sale | $176.86 | 44,547 | 7,878,582 | 168,198 | Feb 05, 2021, 05:03 PM |
| HIGGINS JOHN L | Chief Executive Officer | Jan 25, 2021 | Option Exercise | $156.01 | 7,441 | 1,160,870 | 243,422 | Jan 27, 2021, 07:04 PM |
| HIGGINS JOHN L | Chief Executive Officer | Jan 25, 2021 | Option Exercise | $14.47 | 50,000 | 723,500 | 285,310 | Jan 27, 2021, 07:04 PM |
| HIGGINS JOHN L | Chief Executive Officer | Jan 27, 2021 | Option Exercise | $17.66 | 70,000 | 1,236,400 | 283,422 | Jan 27, 2021, 07:04 PM |
| HIGGINS JOHN L | Chief Executive Officer | Jan 27, 2021 | Sale | $182.00 | 40,000 | 7,280,000 | 243,422 | Jan 27, 2021, 07:04 PM |
| HIGGINS JOHN L | Chief Executive Officer | Jan 25, 2021 | Sale | $159.00 | 50,000 | 7,950,000 | 235,310 | Jan 27, 2021, 07:04 PM |
| FOEHR MATTHEW W | President and COO | Jan 25, 2021 | Option Exercise | $156.01 | 3,325 | 518,733 | 160,603 | Jan 27, 2021, 07:03 PM |
| Korenberg Matthew E | EVP,Finance & Strategy and CFO | Jan 25, 2021 | Option Exercise | $156.01 | 2,111 | 329,337 | 30,933 | Jan 27, 2021, 07:03 PM |
| Berkman Charles S | SVP, Gen. Counsel & Secretary | Jan 25, 2021 | Option Exercise | $156.04 | 1,339 | 208,943 | 43,512 | Jan 27, 2021, 07:02 PM |
| Davis Todd C | Director | Jan 27, 2021 | Option Exercise | $113.50 | 2,456 | 278,756 | 52,761 | Jan 27, 2021, 07:02 PM |
| HIGGINS JOHN L | Chief Executive Officer | Dec 31, 2020 | Option Exercise | $84.53 | 223 | 18,851 | 235,310 | Jan 05, 2021, 08:30 PM |
| HIGGINS JOHN L | Chief Executive Officer | Dec 08, 2020 | Option Exercise | $87.52 | 1,683 | 147,296 | 235,087 | Dec 09, 2020, 06:12 PM |
| HIGGINS JOHN L | Chief Executive Officer | Dec 08, 2020 | Option Exercise | $10.05 | 14,657 | 147,303 | 236,770 | Dec 09, 2020, 06:12 PM |
| HIGGINS JOHN L | Chief Executive Officer | Nov 09, 2020 | Option Exercise | $81.77 | 2,458 | 200,991 | 222,113 | Nov 10, 2020, 07:41 PM |
| HIGGINS JOHN L | Chief Executive Officer | Nov 09, 2020 | Option Exercise | $10.05 | 20,000 | 201,000 | 224,571 | Nov 10, 2020, 07:41 PM |
| Patel Sunil | Director | Nov 02, 2020 | Buy | $82.52 | 1,000 | 82,520 | 28,190 | Nov 04, 2020, 04:19 PM |
| FOEHR MATTHEW W | President and COO | Aug 21, 2020 | Option Exercise | $20.38 | 8,015 | 163,338 | 162,638 | Aug 25, 2020, 07:10 PM |
| FOEHR MATTHEW W | President and COO | Aug 24, 2020 | Option Exercise | $21.92 | 78 | 1,710 | 155,491 | Aug 25, 2020, 07:10 PM |
| FOEHR MATTHEW W | President and COO | Aug 21, 2020 | Sale | $112.88 | 7,225 | 815,544 | 155,413 | Aug 25, 2020, 07:10 PM |
| FOEHR MATTHEW W | President and COO | Aug 24, 2020 | Sale | $110.89 | 78 | 8,649 | 155,413 | Aug 25, 2020, 07:10 PM |
| HIGGINS JOHN L | Chief Executive Officer | Jul 07, 2020 | Option Exercise | $70.01 | 4,315 | 302,098 | 204,571 | Jul 09, 2020, 04:28 PM |
| Berkman Charles S | SVP, Gen. Counsel & Secretary | Jun 30, 2020 | Option Exercise | $89.03 | 238 | 21,189 | 41,115 | Jul 01, 2020, 08:06 PM |
| Korenberg Matthew E | EVP,Finance & Strategy and CFO | Jun 30, 2020 | Option Exercise | $89.03 | 238 | 21,189 | 25,936 | Jul 01, 2020, 08:05 PM |
| Berkman Charles S | SVP, Gen. Counsel & Secretary | Jun 04, 2020 | Sale | $118.59 | 11,146 | 1,321,771 | 40,877 | Jun 05, 2020, 04:07 PM |
| Korenberg Matthew E | EVP,Finance & Strategy and CFO | Feb 15, 2019 | Option Exercise | $120.86 | 1,166 | 140,923 | 16,115 | Apr 24, 2020, 07:24 PM |
| FOEHR MATTHEW W | President and COO | Feb 15, 2019 | Option Exercise | $120.86 | 2,826 | 341,550 | 124,615 | Apr 24, 2020, 07:23 PM |
| HIGGINS JOHN L | Chief Executive Officer | Feb 15, 2019 | Option Exercise | $120.86 | 4,917 | 594,269 | 136,981 | Apr 24, 2020, 07:22 PM |
| FOEHR MATTHEW W | President and COO | Mar 13, 2020 | Option Exercise | $21.92 | 2,000 | 43,840 | 157,449 | Mar 13, 2020, 06:33 PM |
| FOEHR MATTHEW W | President and COO | Feb 27, 2020 | Option Exercise | $15.89 | 8,931 | 141,941 | 160,968 | Feb 27, 2020, 08:35 PM |
| FOEHR MATTHEW W | President and COO | Feb 27, 2020 | Sale | $110.00 | 7,225 | 794,750 | 153,743 | Feb 27, 2020, 08:35 PM |
| HIGGINS JOHN L | Chief Executive Officer | Feb 13, 2020 | Option Exercise | $95.68 | 5,009 | 479,261 | 196,730 | Feb 18, 2020, 05:11 PM |
| HIGGINS JOHN L | Chief Executive Officer | Feb 15, 2020 | Option Exercise | $97.23 | 5,116 | 497,429 | 208,600 | Feb 18, 2020, 05:11 PM |
| HIGGINS JOHN L | Chief Executive Officer | Feb 13, 2020 | Option Exercise | $9.96 | 48,125 | 479,325 | 201,739 | Feb 18, 2020, 05:11 PM |
| FOEHR MATTHEW W | President and COO | Feb 15, 2020 | Option Exercise | $97.23 | 2,486 | 241,714 | 155,360 | Feb 18, 2020, 05:09 PM |
| FOEHR MATTHEW W | President and COO | Feb 14, 2020 | Option Exercise | $14.47 | 7,225 | 104,546 | 163,454 | Feb 18, 2020, 05:09 PM |
| FOEHR MATTHEW W | President and COO | Feb 13, 2020 | Option Exercise | $21.92 | 496 | 10,872 | 148,833 | Feb 18, 2020, 05:09 PM |
| FOEHR MATTHEW W | President and COO | Feb 14, 2020 | Sale | $95.84 | 7,225 | 692,467 | 156,229 | Feb 18, 2020, 05:09 PM |
| Berkman Charles S | SVP, Gen. Counsel & Secretary | Feb 15, 2020 | Option Exercise | $97.23 | 881 | 85,660 | 52,597 | Feb 18, 2020, 05:07 PM |
| Korenberg Matthew E | EVP,Finance & Strategy and CFO | Dec 20, 2019 | Option Exercise | $105.87 | 2,114 | 223,809 | 20,016 | Dec 26, 2019, 02:01 PM |
| Berkman Charles S | SVP, Gen. Counsel & Secretary | Dec 20, 2019 | Option Exercise | $105.87 | 1,131 | 119,739 | 49,069 | Dec 26, 2019, 02:01 PM |
| FOEHR MATTHEW W | President and COO | Dec 20, 2019 | Option Exercise | $105.87 | 3,654 | 386,849 | 148,337 | Dec 26, 2019, 02:01 PM |
| HIGGINS JOHN L | Chief Executive Officer | Dec 20, 2019 | Option Exercise | $105.87 | 6,749 | 714,517 | 153,614 | Dec 26, 2019, 02:00 PM |
| FOEHR MATTHEW W | President and COO | Nov 12, 2019 | Option Exercise | $21.92 | 1,001 | 21,942 | 144,620 | Nov 13, 2019, 04:07 PM |
| FOEHR MATTHEW W | President and COO | Sep 05, 2019 | Option Exercise | $21.92 | 1,005 | 22,030 | 143,619 | Sep 05, 2019, 07:24 PM |
| Aryeh Jason | Director | Sep 03, 2019 | Buy | $87.01 | 750 | 65,258 | 67,203 | Sep 04, 2019, 07:30 PM |
| Korenberg Matthew E | EVP,Finance & Strategy and CFO | Sep 03, 2019 | Buy | $86.18 | 500 | 43,091 | 17,151 | Sep 03, 2019, 07:34 PM |
| FOEHR MATTHEW W | President and COO | Aug 12, 2019 | Option Exercise | $21.92 | 1,163 | 25,493 | 142,614 | Aug 13, 2019, 01:45 PM |
| Aryeh Jason | Director | Aug 05, 2019 | Buy | $90.01 | 746 | 67,146 | 66,453 | Aug 06, 2019, 05:18 PM |
| Berkman Charles S | SVP, Gen. Counsel & Secretary | Aug 05, 2019 | Option Exercise | $67.72 | 1,093 | 74,013 | 47,172 | Aug 06, 2019, 05:17 PM |
| Davis Todd C | Director | Aug 02, 2019 | Buy | $93.59 | 1,000 | 93,594 | 49,474 | Aug 05, 2019, 07:04 PM |
| LAMATTINA JOHN L | Director | Aug 01, 2019 | Option Exercise | $95.58 | 847 | 80,958 | 23,937 | Aug 05, 2019, 07:00 PM |
| LAMATTINA JOHN L | Director | Aug 01, 2019 | Option Exercise | $32.30 | 2,500 | 80,750 | 24,784 | Aug 05, 2019, 07:00 PM |
| Patel Sunil | Director | Aug 02, 2019 | Buy | $95.98 | 1,000 | 95,980 | 26,359 | Aug 05, 2019, 06:56 PM |
| Sabba Stephen L | Director | Jul 31, 2019 | Sale | $94.45 | 4,091 | 386,395 | 23,600 | Aug 01, 2019, 02:49 PM |
| HIGGINS JOHN L | Chief Executive Officer | Jul 31, 2019 | Buy | $95.45 | 1,850 | 176,582 | 146,749 | Jul 31, 2019, 07:26 PM |
| Aryeh Jason | Director | Jul 29, 2019 | Buy | $106.01 | 250 | 26,503 | 61,953 | Jul 31, 2019, 06:50 PM |
| Aryeh Jason | Director | Jul 31, 2019 | Buy | $93.00 | 754 | 70,122 | 65,707 | Jul 31, 2019, 06:50 PM |
| Aryeh Jason | Director | Jul 30, 2019 | Buy | $100.22 | 3,000 | 300,663 | 64,953 | Jul 31, 2019, 06:50 PM |
| Berkman Charles S | SVP, Gen. Counsel & Secretary | Jun 28, 2019 | Option Exercise | $97.03 | 182 | 17,659 | 46,079 | Jul 02, 2019, 09:50 PM |
| Korenberg Matthew E | EVP,Finance & Strategy and CFO | Jun 28, 2019 | Option Exercise | $97.03 | 182 | 17,659 | 16,651 | Jul 02, 2019, 09:49 PM |
| Aryeh Jason | Director | Jun 11, 2019 | Buy | $107.01 | 250 | 26,753 | 61,703 | Jun 12, 2019, 06:51 PM |
| FOEHR MATTHEW W | President and COO | Jun 11, 2019 | Option Exercise | $21.92 | 1,004 | 22,008 | 141,451 | Jun 12, 2019, 06:50 PM |
| HIGGINS JOHN L | Chief Executive Officer | May 31, 2019 | Buy | $108.20 | 1,000 | 108,202 | 144,899 | May 31, 2019, 07:29 PM |
| Aryeh Jason | Director | May 31, 2019 | Buy | $108.51 | 500 | 54,255 | 60,618 | May 31, 2019, 06:27 PM |
| Aryeh Jason | Director | May 30, 2019 | Buy | $110.01 | 250 | 27,503 | 60,118 | May 31, 2019, 06:27 PM |
| Aryeh Jason | Director | May 29, 2019 | Buy | $111.01 | 250 | 27,753 | 59,868 | May 31, 2019, 06:27 PM |
| Aryeh Jason | Director | May 20, 2019 | Buy | $112.01 | 250 | 28,003 | 59,618 | May 22, 2019, 05:36 PM |
| Aryeh Jason | Director | May 14, 2019 | Buy | $112.51 | 250 | 28,128 | 59,368 | May 16, 2019, 03:54 PM |
| HIGGINS JOHN L | Chief Executive Officer | May 14, 2019 | Buy | $113.50 | 2,500 | 283,750 | 143,899 | May 14, 2019, 07:57 PM |
| KOZARICH JOHN W | Director | May 14, 2019 | Option Exercise | $17.88 | 2,500 | 44,700 | 28,042 | May 14, 2019, 07:56 PM |
| KOZARICH JOHN W | Director | May 14, 2019 | Sale | $112.92 | 2,500 | 282,300 | 25,542 | May 14, 2019, 07:56 PM |
| FOEHR MATTHEW W | President and COO | Mar 14, 2019 | Option Exercise | $9.97 | 14,894 | 148,493 | 140,447 | Mar 15, 2019, 02:00 PM |
| Aryeh Jason | Director | Mar 13, 2019 | Buy | $112.51 | 202 | 22,727 | 51,594 | Mar 15, 2019, 01:59 PM |
| HIGGINS JOHN L | Chief Executive Officer | Mar 13, 2019 | Buy | $114.29 | 2,500 | 285,725 | 141,399 | Mar 15, 2019, 01:58 PM |
| FOEHR MATTHEW W | President and COO | Jan 23, 2019 | Option Exercise | $111.78 | 2,568 | 287,051 | 118,081 | Jan 25, 2019, 04:31 PM |
| HIGGINS JOHN L | Chief Executive Officer | Jan 23, 2019 | Option Exercise | $111.78 | 6,765 | 756,192 | 126,090 | Jan 25, 2019, 04:31 PM |
| Korenberg Matthew E | EVP,Finance & Strategy and CFO | Jan 23, 2019 | Option Exercise | $111.78 | 1,325 | 148,108 | 10,065 | Jan 25, 2019, 04:30 PM |
| Berkman Charles S | SVP, Gen. Counsel & Secretary | Jan 10, 2019 | Option Exercise | $65.62 | 2,850 | 187,029 | 39,913 | Jan 14, 2019, 09:17 AM |
| HIGGINS JOHN L | Chief Executive Officer | Jan 10, 2019 | Option Exercise | $16.14 | 33,790 | 545,371 | 119,209 | Jan 14, 2019, 09:16 AM |
| Berkman Charles S | SVP, Gen. Counsel & Secretary | Dec 17, 2018 | Option Exercise | $21.92 | 3,400 | 74,528 | 37,063 | Dec 17, 2018, 07:58 PM |
| FOEHR MATTHEW W | President and COO | Dec 12, 2018 | Option Exercise | $9.97 | 7,999 | 79,750 | 113,387 | Dec 12, 2018, 05:32 PM |
| Berkman Charles S | SVP, Gen. Counsel & Secretary | Oct 24, 2018 | Option Exercise | $16.79 | 3,900 | 65,462 | 33,663 | Oct 25, 2018, 05:44 PM |
| Davis Todd C | Director | Oct 12, 2018 | Option Exercise | $103.29 | 5,083 | 525,021 | 47,639 | Oct 15, 2018, 12:55 PM |
| Berkman Charles S | SVP, Gen. Counsel & Secretary | Oct 11, 2018 | Option Exercise | $14.47 | 2,000 | 28,940 | 29,763 | Oct 12, 2018, 06:52 PM |
| Davis Todd C | Director | Oct 08, 2018 | Sale | $253.99 | 2,500 | 634,977 | 42,556 | Oct 09, 2018, 04:24 PM |
| KOZARICH JOHN W | Director | Oct 01, 2018 | Sale | $275.04 | 2,500 | 687,610 | 26,142 | Oct 02, 2018, 06:24 PM |
| FOEHR MATTHEW W | President and COO | Oct 01, 2018 | Option Exercise | $13.80 | 14,088 | 194,457 | 117,388 | Oct 02, 2018, 06:24 PM |
| FOEHR MATTHEW W | President and COO | Oct 01, 2018 | Sale | $273.88 | 12,000 | 3,286,560 | 105,388 | Oct 02, 2018, 06:24 PM |
| Berkman Charles S | SVP, Gen. Counsel & Secretary | Sep 17, 2018 | Option Exercise | $100.38 | 2,813 | 282,369 | 30,576 | Sep 18, 2018, 06:16 PM |
| Berkman Charles S | SVP, Gen. Counsel & Secretary | Sep 17, 2018 | Sale | $250.69 | 2,813 | 705,183 | 27,763 | Sep 18, 2018, 06:16 PM |
| Sabba Stephen L | Director | Sep 04, 2018 | Option Exercise | $13.23 | 5,000 | 66,150 | 31,856 | Sep 06, 2018, 10:40 AM |
| Sabba Stephen L | Director | Sep 04, 2018 | Sale | $255.05 | 5,000 | 1,275,250 | 26,856 | Sep 06, 2018, 10:40 AM |
| FOEHR MATTHEW W | President and COO | Sep 04, 2018 | Option Exercise | $14.11 | 13,044 | 184,049 | 115,300 | Sep 05, 2018, 08:18 PM |
| FOEHR MATTHEW W | President and COO | Sep 04, 2018 | Sale | $255.01 | 12,000 | 3,060,084 | 103,300 | Sep 05, 2018, 08:18 PM |
| Berkman Charles S | SVP, Gen. Counsel & Secretary | Sep 04, 2018 | Option Exercise | $69.98 | 19,417 | 1,358,796 | 47,180 | Sep 05, 2018, 08:00 PM |
| Berkman Charles S | SVP, Gen. Counsel & Secretary | Sep 04, 2018 | Sale | $254.99 | 19,417 | 4,951,063 | 27,763 | Sep 05, 2018, 08:00 PM |
| LAMATTINA JOHN L | Director | Sep 04, 2018 | Option Exercise | $12.53 | 3,335 | 41,788 | 24,784 | Sep 05, 2018, 07:59 PM |
| LAMATTINA JOHN L | Director | Sep 04, 2018 | Sale | $254.96 | 3,335 | 850,292 | 21,449 | Sep 05, 2018, 07:59 PM |
| HIGGINS JOHN L | Chief Executive Officer | Aug 30, 2018 | Sale | $258.25 | 3,500 | 903,875 | 85,419 | Aug 31, 2018, 01:22 PM |
| Korenberg Matthew E | EVP,Finance & Strategy and CFO | Aug 29, 2018 | Option Exercise | $85.79 | 11,540 | 990,017 | 25,099 | Aug 29, 2018, 08:35 PM |
| Korenberg Matthew E | EVP,Finance & Strategy and CFO | Aug 29, 2018 | Sale | $256.69 | 18,357 | 4,712,058 | 6,742 | Aug 29, 2018, 08:35 PM |
| Aryeh Jason | Director | Aug 17, 2018 | Sale | $241.81 | 26,862 | 6,495,554 | 51,392 | Aug 17, 2018, 07:38 PM |
| Aryeh Jason | Director | Aug 16, 2018 | Sale | $245.00 | 1,080 | 264,600 | 78,254 | Aug 17, 2018, 07:38 PM |
| Davis Todd C | Director | Aug 17, 2018 | Sale | $239.50 | 3,167 | 758,497 | 45,056 | Aug 17, 2018, 07:38 PM |
| Davis Todd C | Director | Aug 16, 2018 | Sale | $239.93 | 5,833 | 1,399,506 | 48,223 | Aug 17, 2018, 07:38 PM |
| HIGGINS JOHN L | Chief Executive Officer | Aug 17, 2018 | Option Exercise | $14.47 | 12,993 | 188,009 | 101,912 | Aug 17, 2018, 07:37 PM |
| HIGGINS JOHN L | Chief Executive Officer | Aug 16, 2018 | Option Exercise | $14.47 | 3,007 | 43,511 | 110,426 | Aug 17, 2018, 07:37 PM |
| HIGGINS JOHN L | Chief Executive Officer | Aug 17, 2018 | Sale | $243.00 | 12,993 | 3,157,299 | 88,919 | Aug 17, 2018, 07:37 PM |
| HIGGINS JOHN L | Chief Executive Officer | Aug 16, 2018 | Sale | $241.33 | 21,507 | 5,190,263 | 88,919 | Aug 17, 2018, 07:37 PM |
| Patel Sunil | Director | Aug 16, 2018 | Option Exercise | $16.70 | 27,005 | 451,058 | 66,811 | Aug 17, 2018, 07:37 PM |
| Patel Sunil | Director | Aug 16, 2018 | Sale | $240.05 | 42,287 | 10,150,825 | 24,524 | Aug 17, 2018, 07:37 PM |
| Korenberg Matthew E | EVP,Finance & Strategy and CFO | Aug 06, 2018 | Option Exercise | $226.74 | 836 | 189,555 | 13,559 | Aug 07, 2018, 04:35 PM |
| KOZARICH JOHN W | Director | Jul 02, 2018 | Sale | $207.48 | 2,500 | 518,700 | 28,642 | Jul 03, 2018, 06:50 PM |
| Korenberg Matthew E | EVP,Finance & Strategy and CFO | Jun 29, 2018 | Option Exercise | $117.84 | 180 | 21,210 | 14,395 | Jul 03, 2018, 03:27 PM |
| Berkman Charles S | SVP, Gen. Counsel & Secretary | Jun 29, 2018 | Option Exercise | $117.84 | 180 | 21,210 | 27,763 | Jul 03, 2018, 03:27 PM |
| LAMATTINA JOHN L | Director | Jun 04, 2018 | Option Exercise | $12.53 | 4,000 | 50,120 | 24,956 | Jun 04, 2018, 07:01 PM |
| LAMATTINA JOHN L | Director | Jun 04, 2018 | Sale | $194.51 | 4,000 | 778,040 | 20,956 | Jun 04, 2018, 07:01 PM |
| HIGGINS JOHN L | Chief Executive Officer | May 15, 2018 | Option Exercise | $16.14 | 12,405 | 200,217 | 119,824 | May 15, 2018, 06:41 PM |
| HIGGINS JOHN L | Chief Executive Officer | May 15, 2018 | Sale | $179.97 | 12,405 | 2,232,491 | 107,419 | May 15, 2018, 06:41 PM |
| FOEHR MATTHEW W | President and COO | May 10, 2018 | Option Exercise | $13.99 | 9,936 | 139,026 | 110,082 | May 11, 2018, 05:32 PM |
| FOEHR MATTHEW W | President and COO | May 10, 2018 | Sale | $167.63 | 8,881 | 1,488,687 | 101,201 | May 11, 2018, 05:32 PM |
| KOZARICH JOHN W | Director | Apr 02, 2018 | Sale | $160.43 | 2,500 | 401,063 | 30,649 | Apr 03, 2018, 12:00 AM |
| Sabba Stephen L | Director | Mar 12, 2018 | Sale | $180.73 | 622 | 112,414 | 26,363 | Mar 13, 2018, 06:15 PM |
| Aryeh Jason | Director | Mar 09, 2018 | Sale | $176.48 | 4,000 | 705,900 | 79,334 | Mar 09, 2018, 06:28 PM |
| Aryeh Jason | Director | Mar 08, 2018 | Sale | $174.88 | 3,500 | 612,094 | 83,334 | Mar 09, 2018, 06:28 PM |
| LAMATTINA JOHN L | Director | Mar 05, 2018 | Option Exercise | $10.12 | 3,335 | 33,750 | 24,291 | Mar 06, 2018, 06:36 PM |
| LAMATTINA JOHN L | Director | Mar 05, 2018 | Sale | $160.90 | 3,335 | 536,605 | 20,956 | Mar 06, 2018, 06:36 PM |
| Korenberg Matthew E | EVP,Finance & Strategy and CFO | Mar 06, 2018 | Option Exercise | $165.87 | 550 | 91,228 | 14,215 | Mar 06, 2018, 06:36 PM |
| Berkman Charles S | SVP, Gen. Counsel & Secretary | Mar 06, 2018 | Option Exercise | $165.87 | 392 | 65,021 | 27,583 | Mar 06, 2018, 06:36 PM |
| HIGGINS JOHN L | Chief Executive Officer | Mar 06, 2018 | Option Exercise | $165.87 | 2,982 | 494,624 | 107,419 | Mar 06, 2018, 06:36 PM |
| FOEHR MATTHEW W | President and COO | Mar 06, 2018 | Option Exercise | $165.87 | 1,457 | 241,673 | 101,201 | Mar 06, 2018, 06:36 PM |
| Aryeh Jason | Director | Feb 23, 2018 | Sale | $155.00 | 3,417 | 529,635 | 86,834 | Feb 27, 2018, 06:40 PM |
| Davis Todd C | Director | Feb 26, 2018 | Sale | $153.57 | 4,835 | 742,535 | 65,898 | Feb 27, 2018, 06:39 PM |
| Davis Todd C | Director | Feb 27, 2018 | Sale | $151.90 | 12,335 | 1,873,711 | 53,563 | Feb 27, 2018, 06:39 PM |
| FOEHR MATTHEW W | President and COO | Feb 23, 2018 | Option Exercise | $13.77 | 6,448 | 88,785 | 101,279 | Feb 27, 2018, 06:39 PM |
| FOEHR MATTHEW W | President and COO | Feb 23, 2018 | Sale | $152.98 | 5,444 | 832,823 | 95,835 | Feb 27, 2018, 06:39 PM |
| Berkman Charles S | SVP, Gen. Counsel & Secretary | Feb 15, 2018 | Option Exercise | $157.18 | 1,036 | 162,838 | 25,571 | Feb 16, 2018, 05:40 PM |
| FOEHR MATTHEW W | President and COO | Feb 15, 2018 | Option Exercise | $157.18 | 3,663 | 575,750 | 96,983 | Feb 16, 2018, 05:39 PM |
| HIGGINS JOHN L | Chief Executive Officer | Feb 15, 2018 | Option Exercise | $157.18 | 6,242 | 981,118 | 100,065 | Feb 16, 2018, 05:38 PM |
| HIGGINS JOHN L | Chief Executive Officer | Feb 15, 2018 | Sale | $157.03 | 9,000 | 1,413,279 | 102,700 | Feb 16, 2018, 05:38 PM |
| Korenberg Matthew E | EVP,Finance & Strategy and CFO | Feb 15, 2018 | Option Exercise | $157.18 | 680 | 106,882 | 10,013 | Feb 16, 2018, 05:37 PM |
| HIGGINS JOHN L | Chief Executive Officer | Jan 24, 2018 | Sale | $165.00 | 22,500 | 3,712,500 | 111,700 | Jan 26, 2018, 05:31 PM |
| HIGGINS JOHN L | Chief Executive Officer | Jan 19, 2018 | Option Exercise | $16.14 | 16,249 | 262,259 | 162,299 | Jan 22, 2018, 07:23 PM |
| HIGGINS JOHN L | Chief Executive Officer | Jan 19, 2018 | Sale | $153.70 | 28,099 | 4,318,906 | 146,050 | Jan 22, 2018, 07:23 PM |
| KOZARICH JOHN W | Director | Jan 10, 2018 | Sale | $145.00 | 2,500 | 362,500 | 33,149 | Jan 11, 2018, 05:55 PM |
| Korenberg Matthew E | VP, Finance and CFO | Dec 28, 2017 | Option Exercise | $138.66 | 1,530 | 212,150 | 10,367 | Dec 29, 2017, 09:17 PM |
| FOEHR MATTHEW W | President and COO | Dec 28, 2017 | Option Exercise | $138.66 | 2,971 | 411,959 | 98,494 | Dec 29, 2017, 09:17 PM |
| HIGGINS JOHN L | Chief Executive Officer | Dec 28, 2017 | Option Exercise | $138.66 | 5,199 | 720,893 | 146,050 | Dec 29, 2017, 09:16 PM |
| Berkman Charles S | VP, Gen. Counsel & Secretary | Dec 28, 2017 | Option Exercise | $138.66 | 1,175 | 162,926 | 26,095 | Dec 29, 2017, 09:16 PM |
| Sabba Stephen L | Director | Dec 20, 2017 | Sale | $137.25 | 925 | 126,956 | 26,985 | Dec 21, 2017, 06:31 AM |
| Aryeh Jason | Director | Nov 17, 2017 | Sale | $140.22 | 24,400 | 3,421,368 | 90,251 | Nov 20, 2017, 05:01 PM |
| HIGGINS JOHN L | Chief Executive Officer | Nov 17, 2017 | Sale | $140.34 | 2,258 | 316,888 | 141,284 | Nov 20, 2017, 05:01 PM |
| LAMATTINA JOHN L | Director | Nov 17, 2017 | Option Exercise | $10.12 | 4,000 | 40,480 | 24,956 | Nov 17, 2017, 07:19 PM |
| LAMATTINA JOHN L | Director | Nov 17, 2017 | Sale | $139.79 | 4,000 | 559,160 | 20,956 | Nov 17, 2017, 07:19 PM |
| KOZARICH JOHN W | Director | Nov 16, 2017 | Sale | $141.71 | 5,000 | 708,550 | 35,649 | Nov 17, 2017, 05:14 PM |
| Korenberg Matthew E | VP, Finance and CFO | Nov 17, 2017 | Sale | $142.63 | 6,559 | 935,510 | 8,147 | Nov 17, 2017, 05:11 PM |
| HIGGINS JOHN L | Chief Executive Officer | Nov 16, 2017 | Sale | $142.53 | 5,269 | 750,991 | 143,542 | Nov 17, 2017, 05:10 PM |
| HIGGINS JOHN L | Chief Executive Officer | Oct 13, 2017 | Option Exercise | $143.04 | 1,744 | 249,462 | 148,811 | Oct 17, 2017, 05:39 PM |
| HIGGINS JOHN L | Chief Executive Officer | Oct 13, 2017 | Option Exercise | $21.92 | 11,384 | 249,537 | 150,555 | Oct 17, 2017, 05:39 PM |
| HIGGINS JOHN L | Chief Executive Officer | Sep 05, 2017 | Option Exercise | $21.00 | 5,000 | 105,000 | 144,171 | Sep 06, 2017, 08:48 PM |
| HIGGINS JOHN L | Chief Executive Officer | Sep 05, 2017 | Sale | $130.00 | 5,000 | 650,000 | 139,171 | Sep 06, 2017, 08:48 PM |
| Aryeh Jason | Director | Aug 23, 2017 | Sale | $127.99 | 2,000 | 255,980 | 114,651 | Aug 25, 2017, 05:36 PM |
| FOEHR MATTHEW W | President and COO | Aug 09, 2017 | Option Exercise | $9.97 | 6,950 | 69,292 | 101,020 | Aug 10, 2017, 06:40 PM |
| FOEHR MATTHEW W | President and COO | Aug 09, 2017 | Sale | $127.51 | 6,100 | 777,823 | 94,920 | Aug 10, 2017, 06:40 PM |
| Berkman Charles S | VP, Gen. Counsel & Secretary | Aug 09, 2017 | Sale | $126.96 | 18,625 | 2,364,667 | 24,423 | Aug 10, 2017, 06:40 PM |
| HIGGINS JOHN L | Chief Executive Officer | Aug 08, 2017 | Option Exercise | $21.00 | 5,483 | 115,143 | 144,654 | Aug 10, 2017, 06:39 PM |
| HIGGINS JOHN L | Chief Executive Officer | Aug 08, 2017 | Sale | $125.00 | 5,483 | 685,375 | 139,171 | Aug 10, 2017, 06:39 PM |
| Korenberg Matthew E | VP, Finance and CFO | Aug 06, 2017 | Option Exercise | $122.06 | 609 | 74,335 | 14,706 | Aug 08, 2017, 05:50 PM |
| Berkman Charles S | VP, Gen. Counsel & Secretary | Jun 30, 2017 | Option Exercise | $87.13 | 243 | 21,171 | 43,048 | Jul 05, 2017, 06:45 PM |
| Korenberg Matthew E | VP, Finance and CFO | Jun 30, 2017 | Option Exercise | $87.13 | 243 | 21,171 | 15,315 | Jul 05, 2017, 06:44 PM |
| HIGGINS JOHN L | Chief Executive Officer | Jun 21, 2017 | Option Exercise | $21.00 | 4,666 | 97,986 | 143,837 | Jun 23, 2017, 04:16 PM |
| HIGGINS JOHN L | Chief Executive Officer | Jun 21, 2017 | Sale | $120.00 | 4,666 | 559,920 | 139,171 | Jun 23, 2017, 04:16 PM |
| HIGGINS JOHN L | Chief Executive Officer | Jun 09, 2017 | Option Exercise | $21.00 | 12,000 | 252,000 | 151,171 | Jun 09, 2017, 07:26 PM |
| HIGGINS JOHN L | Chief Executive Officer | Jun 09, 2017 | Sale | $114.87 | 12,000 | 1,378,440 | 139,171 | Jun 09, 2017, 07:26 PM |
| FOEHR MATTHEW W | President and COO | May 15, 2017 | Option Exercise | $9.97 | 2,200 | 21,934 | 94,920 | May 15, 2017, 07:05 PM |
| FOEHR MATTHEW W | President and COO | May 12, 2017 | Option Exercise | $9.97 | 5,621 | 56,041 | 98,341 | May 15, 2017, 07:05 PM |
| FOEHR MATTHEW W | President and COO | May 12, 2017 | Sale | $112.19 | 5,621 | 630,648 | 92,720 | May 15, 2017, 07:05 PM |
| Aryeh Jason | Director | May 12, 2017 | Sale | $111.87 | 14,582 | 1,631,332 | 116,651 | May 12, 2017, 08:06 PM |
| Aryeh Jason | Director | May 11, 2017 | Sale | $110.04 | 22,665 | 2,494,034 | 131,233 | May 12, 2017, 08:06 PM |
| HIGGINS JOHN L | Chief Executive Officer | Mar 20, 2017 | Sale | $109.10 | 4,000 | 436,400 | 139,171 | Mar 21, 2017, 05:49 PM |
| HIGGINS JOHN L | Chief Executive Officer | Mar 08, 2017 | Option Exercise | $106.92 | 1,473 | 157,493 | 143,171 | Mar 10, 2017, 06:03 PM |
| HIGGINS JOHN L | Chief Executive Officer | Mar 08, 2017 | Option Exercise | $10.05 | 15,675 | 157,534 | 144,644 | Mar 10, 2017, 06:03 PM |
| HIGGINS JOHN L | Chief Executive Officer | Mar 08, 2017 | Sale | $107.06 | 4,000 | 428,240 | 128,969 | Mar 10, 2017, 06:03 PM |
| FOEHR MATTHEW W | President and COO | Mar 03, 2017 | Option Exercise | $9.97 | 2,000 | 19,940 | 92,720 | Mar 03, 2017, 06:54 PM |
| FOEHR MATTHEW W | President and COO | Mar 02, 2017 | Option Exercise | $9.97 | 6,879 | 68,584 | 97,599 | Mar 03, 2017, 06:54 PM |
| FOEHR MATTHEW W | President and COO | Mar 02, 2017 | Sale | $103.39 | 6,879 | 711,213 | 90,720 | Mar 03, 2017, 06:54 PM |
| Aryeh Jason | Director | Feb 28, 2017 | Sale | $107.58 | 7,000 | 753,060 | 153,898 | Feb 28, 2017, 08:30 PM |
| Aryeh Jason | Director | Feb 27, 2017 | Sale | $106.00 | 25,000 | 2,650,000 | 160,898 | Feb 28, 2017, 08:30 PM |
| Korenberg Matthew E | VP, Finance and CFO | Feb 24, 2017 | Option Exercise | $100.38 | 1,051 | 105,499 | 11,505 | Feb 28, 2017, 06:27 PM |
| Korenberg Matthew E | VP, Finance and CFO | Feb 15, 2017 | Option Exercise | $104.28 | 391 | 40,773 | 9,106 | Feb 28, 2017, 06:27 PM |
| Korenberg Matthew E | VP, Finance and CFO | Aug 06, 2016 | Option Exercise | $123.30 | 609 | 75,090 | 9,457 | Feb 28, 2017, 06:27 PM |
| FOEHR MATTHEW W | President and COO | Feb 24, 2017 | Option Exercise | $100.38 | 2,733 | 274,339 | 83,176 | Feb 28, 2017, 06:27 PM |
| FOEHR MATTHEW W | President and COO | Feb 15, 2017 | Option Exercise | $104.28 | 2,367 | 246,831 | 81,395 | Feb 28, 2017, 06:27 PM |
| HIGGINS JOHN L | Chief Executive Officer | Feb 24, 2017 | Option Exercise | $100.38 | 4,783 | 480,118 | 122,745 | Feb 28, 2017, 06:26 PM |
| HIGGINS JOHN L | Chief Executive Officer | Feb 15, 2017 | Option Exercise | $104.28 | 4,304 | 448,821 | 120,379 | Feb 28, 2017, 06:26 PM |
| Korenberg Matthew E | VP, Finance and CFO | Dec 30, 2016 | Option Exercise | $86.37 | 40 | 3,455 | 10,106 | Jan 03, 2017, 04:38 PM |
| Aryeh Jason | Director | Nov 25, 2016 | Sale | $106.96 | 3,478 | 372,007 | 185,898 | Nov 25, 2016, 05:58 PM |
| Aryeh Jason | Director | Nov 22, 2016 | Sale | $107.40 | 15,001 | 1,611,062 | 189,376 | Nov 25, 2016, 05:58 PM |
| Aryeh Jason | Director | Nov 16, 2016 | Sale | $106.33 | 1,330 | 141,419 | 209,377 | Nov 18, 2016, 04:48 PM |
| Aryeh Jason | Director | Nov 18, 2016 | Sale | $105.00 | 5,000 | 525,000 | 204,377 | Nov 18, 2016, 04:48 PM |
| Davis Todd C | Director | Oct 31, 2016 | Option Exercise | $45.66 | 13,980 | 638,362 | 70,189 | Nov 01, 2016, 08:18 PM |
| HIGGINS JOHN L | Chief Executive Officer | Sep 22, 2016 | Sale | $117.34 | 3,000 | 352,020 | 122,664 | Sep 23, 2016, 04:19 PM |
| KOZARICH JOHN W | Director | Sep 07, 2016 | Sale | $115.00 | 1,000 | 115,000 | 39,983 | Sep 09, 2016, 04:06 PM |
| KOZARICH JOHN W | Director | Sep 01, 2016 | Option Exercise | $45.60 | 1,666 | 75,970 | 40,983 | Sep 09, 2016, 04:05 PM |
| KOZARICH JOHN W | Director | Sep 01, 2016 | Sale | $105.40 | 1,666 | 175,597 | 40,783 | Sep 06, 2016, 06:07 PM |
| FOEHR MATTHEW W | President and COO | Aug 08, 2016 | Option Exercise | $9.97 | 4,125 | 41,126 | 83,037 | Aug 09, 2016, 04:58 PM |
| FOEHR MATTHEW W | President and COO | Aug 05, 2016 | Option Exercise | $9.97 | 12,500 | 124,625 | 91,412 | Aug 09, 2016, 04:58 PM |
| FOEHR MATTHEW W | President and COO | Aug 05, 2016 | Sale | $122.14 | 12,500 | 1,526,750 | 78,912 | Aug 09, 2016, 04:58 PM |
| Berkman Charles S | VP, Gen. Counsel & Secretary | Aug 05, 2016 | Option Exercise | $54.76 | 30,347 | 1,661,857 | 41,731 | Aug 09, 2016, 04:58 PM |
| Berkman Charles S | VP, Gen. Counsel & Secretary | Aug 05, 2016 | Sale | $123.16 | 22,067 | 2,717,772 | 29,647 | Aug 09, 2016, 04:58 PM |
| KOZARICH JOHN W | Director | Aug 01, 2016 | Sale | $137.57 | 1,000 | 137,569 | 41,783 | Aug 02, 2016, 07:46 PM |
| Korenberg Matthew E | VP, Finance and CFO | Jun 30, 2016 | Option Exercise | $87.10 | 196 | 17,072 | 10,066 | Jul 05, 2016, 07:58 PM |
| Herman Melanie J | Director of Accounting | Jun 30, 2016 | Option Exercise | $87.10 | 157 | 13,675 | 3,454 | Jul 05, 2016, 07:56 PM |
| KOZARICH JOHN W | Director | Jul 01, 2016 | Sale | $121.40 | 1,000 | 121,402 | 42,883 | Jul 05, 2016, 07:56 PM |
| KOZARICH JOHN W | Director | Jun 01, 2016 | Sale | $117.42 | 1,000 | 117,419 | 43,083 | Jun 03, 2016, 04:41 PM |
| Herman Melanie J | Director of Accounting | May 18, 2016 | Sale | $120.50 | 334 | 40,247 | 3,297 | May 19, 2016, 06:28 PM |
| Aryeh Jason | Director | May 06, 2016 | Sale | $118.52 | 15,000 | 1,777,830 | 210,707 | May 09, 2016, 08:00 AM |
| Aryeh Jason | Director | May 05, 2016 | Sale | $120.21 | 10,000 | 1,202,120 | 225,707 | May 09, 2016, 08:00 AM |
| KOZARICH JOHN W | Director | May 02, 2016 | Sale | $121.57 | 1,000 | 121,568 | 43,911 | May 03, 2016, 05:34 PM |
| KOZARICH JOHN W | Director | Apr 06, 2016 | Sale | $115.00 | 5,000 | 575,000 | 44,711 | Apr 07, 2016, 05:30 PM |
| FOEHR MATTHEW W | President and COO | Mar 17, 2016 | Option Exercise | $9.97 | 8,650 | 86,241 | 83,062 | Mar 17, 2016, 07:56 PM |
| FOEHR MATTHEW W | President and COO | Mar 17, 2016 | Sale | $96.70 | 6,400 | 618,880 | 76,662 | Mar 17, 2016, 07:56 PM |
| Aryeh Jason | Director | Mar 08, 2016 | Sale | $102.49 | 500 | 51,245 | 235,707 | Mar 09, 2016, 06:26 PM |
| Aryeh Jason | Director | Mar 07, 2016 | Sale | $101.07 | 5,629 | 568,895 | 236,207 | Mar 09, 2016, 06:26 PM |
| HIGGINS JOHN L | Chief Executive Officer | Mar 08, 2016 | Option Exercise | $21.00 | 6,000 | 126,000 | 125,664 | Mar 09, 2016, 06:26 PM |
| HIGGINS JOHN L | Chief Executive Officer | Mar 07, 2016 | Sale | $102.47 | 10,833 | 1,110,027 | 120,220 | Mar 09, 2016, 06:26 PM |
| HIGGINS JOHN L | Chief Executive Officer | Feb 15, 2016 | Option Exercise | $85.97 | 2,492 | 214,237 | 130,497 | Feb 16, 2016, 07:34 PM |
| FOEHR MATTHEW W | President and COO | Feb 15, 2016 | Option Exercise | $85.97 | 1,642 | 141,163 | 76,662 | Feb 16, 2016, 07:34 PM |
| Herman Melanie J | Director of Accounting | Feb 15, 2016 | Option Exercise | $85.97 | 160 | 13,755 | 3,631 | Feb 16, 2016, 07:33 PM |
| KOZARICH JOHN W | Director | Jan 20, 2016 | Option Exercise | $59.40 | 1,666 | 98,960 | 51,377 | Jan 22, 2016, 07:24 PM |
| KOZARICH JOHN W | Director | Jan 20, 2016 | Sale | $94.94 | 1,666 | 158,173 | 51,077 | Jan 22, 2016, 07:24 PM |
| Herman Melanie J | Director of Accounting | Dec 31, 2015 | Option Exercise | $82.53 | 140 | 11,554 | 3,291 | Jan 04, 2016, 05:24 PM |
| Aryeh Jason | Director | Nov 11, 2015 | Sale | $101.49 | 3,000 | 304,470 | 241,836 | Nov 13, 2015, 05:29 PM |
| Herman Melanie J | Director of Accounting | Nov 11, 2015 | Option Exercise | $47.29 | 7,719 | 365,034 | 10,870 | Nov 13, 2015, 05:28 PM |
| Herman Melanie J | Director of Accounting | Nov 11, 2015 | Sale | $101.00 | 7,719 | 779,619 | 3,151 | Nov 13, 2015, 05:28 PM |
| KNOTT DAVID M | Director | Aug 17, 2015 | Sale | $95.98 | 4,000 | 383,937 | 66,152 | Aug 19, 2015, 06:00 AM |
| KNOTT DAVID M | Director | Aug 12, 2015 | Sale | $96.45 | 9,875 | 952,486 | 223,486 | Aug 14, 2015, 12:53 PM |
| KNOTT DAVID M | Director | Aug 12, 2015 | Sale | $96.45 | 800 | 77,163 | 971,300 | Aug 14, 2015, 12:53 PM |
| KNOTT DAVID M | Director | Aug 13, 2015 | Sale | $96.20 | 7,225 | 695,014 | 30,771 | Aug 14, 2015, 12:53 PM |
| KNOTT DAVID M | Director | Aug 13, 2015 | Sale | $96.20 | 27,300 | 2,626,143 | 196,186 | Aug 14, 2015, 12:53 PM |
| KNOTT DAVID M | Director | Aug 13, 2015 | Sale | $96.20 | 2,000 | 192,391 | 969,300 | Aug 14, 2015, 12:53 PM |
| KNOTT DAVID M | Director | Aug 12, 2015 | Sale | $96.45 | 2,600 | 250,781 | 37,996 | Aug 14, 2015, 12:53 PM |
| KNOTT DAVID M | Director | Aug 07, 2015 | Sale | $99.01 | 200 | 19,803 | 40,596 | Aug 11, 2015, 06:51 AM |
| HIGGINS JOHN L | Chief Executive Officer | Aug 06, 2015 | Sale | $110.79 | 4,666 | 516,946 | 121,378 | Aug 07, 2015, 04:22 PM |
| Davis Todd C | Director | Aug 06, 2015 | Option Exercise | $11.81 | 19,670 | 232,288 | 55,449 | Aug 06, 2015, 07:49 PM |
| Berkman Charles S | VP, Gen. Counsel & Secretary | Jul 13, 2015 | Option Exercise | $53.10 | 1,000 | 53,100 | 27,454 | Jul 14, 2015, 07:35 PM |
| Berkman Charles S | VP, Gen. Counsel & Secretary | Jul 10, 2015 | Option Exercise | $12.70 | 14,067 | 178,687 | 40,521 | Jul 14, 2015, 07:35 PM |
| Berkman Charles S | VP, Gen. Counsel & Secretary | Jul 10, 2015 | Sale | $99.14 | 14,067 | 1,394,610 | 38,117 | Jul 14, 2015, 07:35 PM |
| Berkman Charles S | VP, Gen. Counsel & Secretary | Jun 30, 2015 | Option Exercise | $45.67 | 465 | 21,237 | 26,454 | Jul 01, 2015, 12:36 PM |
| Herman Melanie J | Interim CFO | Jun 30, 2015 | Option Exercise | $45.67 | 165 | 7,536 | 3,151 | Jul 01, 2015, 12:36 PM |
| FOEHR MATTHEW W | President and COO | Jun 29, 2015 | Option Exercise | $9.97 | 2,500 | 24,925 | 72,628 | Jun 30, 2015, 05:39 PM |
| FOEHR MATTHEW W | President and COO | Jun 26, 2015 | Option Exercise | $9.97 | 12,500 | 124,625 | 82,628 | Jun 30, 2015, 05:39 PM |
| FOEHR MATTHEW W | President and COO | Jun 26, 2015 | Sale | $100.97 | 12,500 | 1,262,125 | 70,128 | Jun 30, 2015, 05:39 PM |
| FOEHR MATTHEW W | President and COO | Jun 22, 2015 | Option Exercise | $9.97 | 25,046 | 249,709 | 91,174 | Jun 24, 2015, 06:52 PM |
| FOEHR MATTHEW W | President and COO | Jun 22, 2015 | Sale | $96.45 | 23,046 | 2,222,815 | 86,628 | Jun 24, 2015, 06:52 PM |
| Herman Melanie J | Interim CFO | Jun 10, 2015 | Option Exercise | $38.03 | 4,125 | 156,885 | 7,111 | Jun 11, 2015, 06:17 PM |
| Herman Melanie J | Interim CFO | Jun 10, 2015 | Sale | $93.50 | 4,125 | 385,688 | 2,986 | Jun 11, 2015, 06:17 PM |
| HIGGINS JOHN L | Chief Executive Officer | Jun 09, 2015 | Sale | $92.88 | 10,000 | 928,809 | 129,844 | Jun 11, 2015, 06:13 PM |
| Aryeh Jason | Director | Jun 04, 2015 | Sale | $92.68 | 1,640 | 151,995 | 244,836 | Jun 08, 2015, 08:43 PM |
| Aryeh Jason | Director | May 20, 2015 | Sale | $87.65 | 1,000 | 87,650 | 246,476 | May 20, 2015, 05:28 PM |
| Aryeh Jason | Director | May 19, 2015 | Sale | $88.82 | 2,240 | 198,957 | 247,476 | May 20, 2015, 05:28 PM |
| Aryeh Jason | Director | May 18, 2015 | Sale | $86.74 | 6,000 | 520,440 | 249,716 | May 20, 2015, 05:28 PM |
| DeSilva Nishan M | VP, Finance & Strategy and CFO | May 13, 2015 | Option Exercise | $18.26 | 23,905 | 436,408 | 34,430 | May 14, 2015, 05:39 PM |
| DeSilva Nishan M | VP, Finance & Strategy and CFO | May 12, 2015 | Option Exercise | $17.42 | 23,520 | 409,664 | 36,496 | May 14, 2015, 05:39 PM |
| DeSilva Nishan M | VP, Finance & Strategy and CFO | May 14, 2015 | Option Exercise | $74.42 | 20,938 | 1,558,206 | 43,220 | May 14, 2015, 05:39 PM |
| DeSilva Nishan M | VP, Finance & Strategy and CFO | May 13, 2015 | Sale | $83.27 | 23,905 | 1,990,671 | 22,282 | May 14, 2015, 05:39 PM |
| DeSilva Nishan M | VP, Finance & Strategy and CFO | May 12, 2015 | Sale | $84.63 | 23,520 | 1,990,403 | 22,282 | May 14, 2015, 05:39 PM |
| DeSilva Nishan M | VP, Finance & Strategy and CFO | May 14, 2015 | Sale | $83.84 | 20,938 | 1,755,442 | 22,282 | May 14, 2015, 05:39 PM |
| Patel Sunil | Director | Mar 19, 2015 | Sale | $74.42 | 4,591 | 341,662 | 37,100 | Mar 20, 2015, 04:44 PM |
| Berkman Charles S | VP, Gen. Counsel & Secretary | Mar 16, 2015 | Option Exercise | $20.32 | 5,264 | 106,939 | 30,119 | Mar 18, 2015, 04:32 PM |
| Berkman Charles S | VP, Gen. Counsel & Secretary | Mar 16, 2015 | Sale | $74.54 | 11,264 | 839,649 | 25,989 | Mar 18, 2015, 04:32 PM |
| Berkman Charles S | VP, Gen. Counsel & Secretary | Dec 31, 2014 | Option Exercise | $45.23 | 126 | 5,699 | 27,433 | Mar 18, 2015, 04:28 PM |
| Herman Melanie J | Director of Accounting | Mar 02, 2015 | Sale | $60.69 | 535 | 32,469 | 2,986 | Mar 03, 2015, 04:04 PM |
| Herman Melanie J | Director of Accounting | Dec 31, 2014 | Option Exercise | $45.23 | 103 | 4,659 | 2,831 | Feb 25, 2015, 06:00 PM |
| Herman Melanie J | Director of Accounting | Feb 19, 2015 | Sale | $57.84 | 510 | 29,498 | 3,521 | Feb 20, 2015, 04:49 PM |
| DeSilva Nishan M | VP, Corporate Development | Feb 10, 2015 | Sale | $56.34 | 2,300 | 129,582 | 16,359 | Feb 11, 2015, 08:06 PM |
| Berkman Charles S | VP, Gen. Counsel & Secretary | Dec 31, 2014 | Buy | $45.23 | 126 | 5,699 | 27,433 | Jan 05, 2015, 07:47 PM |
| FOEHR MATTHEW W | EVP and COO | Dec 31, 2014 | Buy | $45.23 | 46 | 2,081 | 55,016 | Jan 05, 2015, 07:46 PM |
| Herman Melanie J | Director of Accounting | Dec 31, 2014 | Buy | $45.23 | 103 | 4,659 | 2,831 | Jan 05, 2015, 07:46 PM |
| KOZARICH JOHN W | Director | Oct 15, 2014 | Buy | $45.68 | 2,000 | 91,360 | 49,286 | Oct 15, 2014, 07:02 PM |
| FOEHR MATTHEW W | EVP and COO | Oct 13, 2014 | Option Exercise | $9.97 | 1,000 | 9,970 | 54,970 | Oct 14, 2014, 01:48 PM |
| FOEHR MATTHEW W | EVP and COO | Oct 10, 2014 | Buy | $44.91 | 85 | 3,817 | 53,970 | Oct 14, 2014, 01:48 PM |
| Sabba Stephen L | Director | Oct 09, 2014 | Buy | $43.12 | 2,000 | 86,230 | 23,697 | Oct 14, 2014, 01:03 PM |
| KNOTT DAVID M | Director | Oct 09, 2014 | Buy | $43.01 | 4,000 | 172,029 | 69,227 | Oct 14, 2014, 01:03 PM |
| Sabba Stephen L | Director | Oct 09, 2014 | Option Exercise | $43.12 | 2,000 | 86,230 | 23,697 | Oct 10, 2014, 03:03 PM |
| KNOTT DAVID M | Director | Oct 09, 2014 | Option Exercise | $43.01 | 4,000 | 172,029 | 69,227 | Oct 10, 2014, 02:29 PM |
| Aryeh Jason | Director | Oct 09, 2014 | Buy | $42.99 | 11,000 | 472,890 | 255,716 | Oct 09, 2014, 07:04 PM |
| KOZARICH JOHN W | Director | Oct 07, 2014 | Option Exercise | $8.58 | 2,500 | 21,450 | 47,286 | Oct 09, 2014, 01:50 PM |
| Aryeh Jason | Director | Oct 01, 2014 | Option Exercise | $32.30 | 7,335 | 236,920 | 60,695 | Oct 01, 2014, 06:24 PM |
| Aryeh Jason | Director | Sep 25, 2014 | Option Exercise | $11.65 | 20,300 | 236,584 | 53,360 | Sep 29, 2014, 01:50 PM |
| HIGGINS JOHN L | President & CEO | Aug 15, 2014 | Buy | $54.97 | 1,000 | 54,970 | 120,099 | Aug 15, 2014, 02:51 PM |
| Herman Melanie J | Director of Accounting | Jun 30, 2014 | Buy | $43.79 | 98 | 4,292 | 2,728 | Jul 01, 2014, 12:16 PM |
| Berkman Charles S | VP, Gen. Counsel & Secretary | Jun 30, 2014 | Buy | $43.79 | 329 | 14,408 | 27,307 | Jul 01, 2014, 12:16 PM |
| FOEHR MATTHEW W | EVP and COO | Jun 30, 2014 | Buy | $43.79 | 428 | 18,743 | 53,885 | Jul 01, 2014, 12:16 PM |
| Herman Melanie J | Director of Accounting | Jun 09, 2014 | Option Exercise | $12.49 | 1,100 | 13,741 | 3,480 | Jun 10, 2014, 04:29 PM |
| Herman Melanie J | Director of Accounting | Jun 09, 2014 | Sale | $69.68 | 1,100 | 76,648 | 2,630 | Jun 10, 2014, 04:29 PM |
| Berkman Charles S | VP, Gen. Counsel & Secretary | May 27, 2014 | Option Exercise | $18.81 | 2,499 | 47,007 | 28,644 | May 28, 2014, 06:03 PM |
| Berkman Charles S | VP, Gen. Counsel & Secretary | May 27, 2014 | Sale | $66.90 | 7,166 | 479,434 | 26,978 | May 28, 2014, 06:03 PM |
| BVF PARTNERS L P/IL | See Explanation of Responses | Mar 24, 2014 | Sale | $70.17 | 31,698 | 2,224,163 | 248,144 | Mar 26, 2014, 07:28 PM |
| BVF PARTNERS L P/IL | See Explanation of Responses | Mar 25, 2014 | Sale | $69.95 | 10,203 | 713,734 | 130,175 | Mar 26, 2014, 07:28 PM |
| BVF PARTNERS L P/IL | See Explanation of Responses | Mar 25, 2014 | Sale | $69.95 | 18,019 | 1,260,489 | 230,125 | Mar 26, 2014, 07:28 PM |
| BVF PARTNERS L P/IL | See Explanation of Responses | Mar 24, 2014 | Sale | $70.17 | 18,306 | 1,284,483 | 140,378 | Mar 26, 2014, 07:28 PM |
| Davis Todd C | Director | Mar 19, 2014 | Sale | $79.63 | 5,000 | 398,147 | 32,536 | Mar 20, 2014, 06:40 PM |
| Davis Todd C | Director | Mar 18, 2014 | Sale | $79.45 | 2,500 | 198,637 | 37,536 | Mar 20, 2014, 06:40 PM |
| LAMATTINA JOHN L | Director | Mar 18, 2014 | Option Exercise | $8.97 | 5,000 | 44,850 | 26,356 | Mar 20, 2014, 06:40 PM |
| LAMATTINA JOHN L | Director | Mar 18, 2014 | Sale | $78.83 | 5,000 | 394,150 | 21,356 | Mar 20, 2014, 06:40 PM |
| Sabba Stephen L | Director | Feb 27, 2014 | Sale | $72.25 | 500 | 36,125 | 20,546 | Feb 28, 2014, 11:37 AM |
| KNOTT DAVID M | Director | Feb 20, 2014 | Sale | $72.97 | 900 | 65,676 | 1,843 | Feb 21, 2014, 10:43 AM |
| BVF PARTNERS L P/IL | 10% Owner | Feb 18, 2014 | Sale | $74.66 | 14,003 | 1,045,409 | 87,520 | Feb 20, 2014, 08:00 PM |
| BVF PARTNERS L P/IL | 10% Owner | Feb 20, 2014 | Sale | $73.05 | 10,557 | 771,167 | 158,684 | Feb 20, 2014, 08:00 PM |
| BVF PARTNERS L P/IL | 10% Owner | Feb 18, 2014 | Sale | $74.66 | 153,751 | 11,478,450 | 1,855,083 | Feb 20, 2014, 08:00 PM |
| BVF PARTNERS L P/IL | 10% Owner | Feb 20, 2014 | Sale | $73.05 | 18,615 | 1,359,787 | 279,842 | Feb 20, 2014, 08:00 PM |
| BVF PARTNERS L P/IL | 10% Owner | Feb 18, 2014 | Sale | $74.66 | 16,331 | 1,219,209 | 174,636 | Feb 20, 2014, 08:00 PM |
| BVF PARTNERS L P/IL | 10% Owner | Feb 19, 2014 | Sale | $73.03 | 2,771 | 202,375 | 84,749 | Feb 20, 2014, 08:00 PM |
| BVF PARTNERS L P/IL | 10% Owner | Feb 18, 2014 | Sale | $74.66 | 16,915 | 1,262,808 | 307,921 | Feb 20, 2014, 08:00 PM |
| BVF PARTNERS L P/IL | 10% Owner | Feb 19, 2014 | Sale | $73.03 | 57,370 | 4,189,921 | 1,797,713 | Feb 20, 2014, 08:00 PM |
| BVF PARTNERS L P/IL | 10% Owner | Feb 19, 2014 | Sale | $73.03 | 5,395 | 394,015 | 169,241 | Feb 20, 2014, 08:00 PM |
| BVF PARTNERS L P/IL | 10% Owner | Feb 20, 2014 | Sale | $73.05 | 5,359 | 391,464 | 79,390 | Feb 20, 2014, 08:00 PM |
| BVF PARTNERS L P/IL | 10% Owner | Feb 19, 2014 | Sale | $73.03 | 9,464 | 691,187 | 298,457 | Feb 20, 2014, 08:00 PM |
| BVF PARTNERS L P/IL | 10% Owner | Feb 20, 2014 | Sale | $73.05 | 112,369 | 8,208,319 | 1,685,344 | Feb 20, 2014, 08:00 PM |
| KNOTT DAVID M | Director | Feb 14, 2014 | Sale | $77.10 | 19,769 | 1,524,229 | 244,892 | Feb 19, 2014, 12:16 PM |
| KNOTT DAVID M | Director | Feb 18, 2014 | Sale | $73.31 | 3,900 | 285,919 | 40,796 | Feb 19, 2014, 12:16 PM |
| KNOTT DAVID M | Director | Feb 18, 2014 | Sale | $73.31 | 11,531 | 845,368 | 233,361 | Feb 19, 2014, 12:16 PM |
| KNOTT DAVID M | Director | Feb 14, 2014 | Sale | $77.10 | 6,700 | 516,583 | 44,696 | Feb 19, 2014, 12:16 PM |
| Aryeh Jason | Director | Feb 14, 2014 | Sale | $78.87 | 9,500 | 749,265 | 244,716 | Feb 14, 2014, 08:20 PM |
| Aryeh Jason | Director | Feb 13, 2014 | Sale | $77.43 | 6,700 | 518,779 | 254,216 | Feb 14, 2014, 08:20 PM |
| Aryeh Jason | Director | Feb 12, 2014 | Sale | $75.21 | 24,120 | 1,814,121 | 260,916 | Feb 14, 2014, 08:20 PM |
| Sharp John P | VP Finance and CFO | Feb 12, 2014 | Option Exercise | $17.57 | 86,953 | 1,528,059 | 34,333 | Feb 14, 2014, 08:18 PM |
| Sharp John P | VP Finance and CFO | Feb 12, 2014 | Sale | $74.74 | 86,953 | 6,498,898 | 17,667 | Feb 14, 2014, 08:18 PM |
| Berkman Charles S | VP, Gen. Counsel & Secretary | Feb 12, 2014 | Option Exercise | $16.18 | 14,881 | 240,784 | 34,424 | Feb 14, 2014, 08:06 PM |
| Berkman Charles S | VP, Gen. Counsel & Secretary | Feb 13, 2014 | Option Exercise | $14.47 | 2,000 | 28,940 | 31,645 | Feb 14, 2014, 08:06 PM |
| Berkman Charles S | VP, Gen. Counsel & Secretary | Feb 12, 2014 | Sale | $74.50 | 14,881 | 1,108,635 | 29,645 | Feb 14, 2014, 08:06 PM |
| HIGGINS JOHN L | President & CEO | Feb 12, 2014 | Option Exercise | $9.96 | 16,875 | 168,075 | 127,974 | Feb 14, 2014, 08:04 PM |
| HIGGINS JOHN L | President & CEO | Feb 12, 2014 | Sale | $75.00 | 16,875 | 1,265,625 | 111,099 | Feb 14, 2014, 08:04 PM |
| FOEHR MATTHEW W | EVP and COO | Feb 14, 2014 | Option Exercise | $9.97 | 25,944 | 258,662 | 75,957 | Feb 14, 2014, 08:00 PM |
| FOEHR MATTHEW W | EVP and COO | Feb 14, 2014 | Sale | $79.54 | 22,500 | 1,789,650 | 53,457 | Feb 14, 2014, 08:00 PM |
| HIGGINS JOHN L | President & CEO | Jan 21, 2014 | Option Exercise | $21.00 | 9,000 | 189,000 | 111,099 | Jan 21, 2014, 08:04 PM |
| HIGGINS JOHN L | President & CEO | Jan 16, 2014 | Sale | $64.00 | 15,000 | 960,000 | 102,099 | Jan 21, 2014, 08:04 PM |
| FOEHR MATTHEW W | EVP and COO | Dec 31, 2013 | Buy | $33.92 | 84 | 2,849 | 45,013 | Jan 02, 2014, 04:48 PM |
| Berkman Charles S | VP, Gen. Counsel & Secretary | Dec 31, 2013 | Buy | $33.92 | 209 | 7,088 | 27,145 | Jan 02, 2014, 04:48 PM |
| Sharp John P | VP Finance and CFO | Dec 12, 2013 | Option Exercise | $9.96 | 700 | 6,972 | 18,367 | Dec 16, 2013, 05:09 PM |
| Sharp John P | VP Finance and CFO | Dec 12, 2013 | Sale | $53.44 | 700 | 37,408 | 17,667 | Dec 16, 2013, 05:09 PM |
| FOEHR MATTHEW W | EVP and COO | Dec 12, 2013 | Option Exercise | $9.97 | 6,000 | 59,820 | 50,929 | Dec 13, 2013, 06:46 PM |
| FOEHR MATTHEW W | EVP and COO | Dec 12, 2013 | Sale | $53.40 | 6,000 | 320,400 | 44,929 | Dec 13, 2013, 06:46 PM |
| Sharp John P | VP Finance and CFO | Dec 06, 2013 | Sale | $56.08 | 6,000 | 336,480 | 17,667 | Dec 09, 2013, 06:53 PM |
| BVF PARTNERS L P/IL | 10% Owner | Nov 27, 2013 | Sale | $57.07 | 319,005 | 18,207,114 | 2,008,834 | Nov 29, 2013, 11:38 AM |
| BVF PARTNERS L P/IL | 10% Owner | Nov 26, 2013 | Sale | $57.57 | 208,500 | 12,003,345 | 411,271 | Nov 29, 2013, 11:38 AM |
| KOZARICH JOHN W | Director | Nov 25, 2013 | Option Exercise | $7.11 | 1,243 | 8,833 | 42,969 | Nov 27, 2013, 11:29 AM |
| KOZARICH JOHN W | Director | Nov 18, 2013 | Option Exercise | $14.86 | 460 | 6,836 | 41,726 | Nov 20, 2013, 08:46 PM |
| Sharp John P | VP Finance and CFO | Nov 18, 2013 | Option Exercise | $9.96 | 624 | 6,215 | 24,790 | Nov 20, 2013, 06:49 PM |
| Sharp John P | VP Finance and CFO | Nov 18, 2013 | Sale | $53.00 | 1,123 | 59,519 | 23,667 | Nov 20, 2013, 06:49 PM |
| HIGGINS JOHN L | President & CEO | Oct 22, 2013 | Option Exercise | $16.14 | 10,518 | 169,763 | 117,099 | Oct 22, 2013, 08:05 PM |
| HIGGINS JOHN L | President & CEO | Oct 18, 2013 | Sale | $55.00 | 10,000 | 550,000 | 106,581 | Oct 22, 2013, 08:05 PM |
| BVF PARTNERS L P/IL | 10% Owner | Sep 23, 2013 | Sale | $44.50 | 359,023 | 15,976,524 | 530,410 | Sep 25, 2013, 06:54 PM |
| KNOTT DAVID M | Director | Sep 12, 2013 | Sale | $46.78 | 160,000 | 7,484,080 | 51,396 | Sep 13, 2013, 03:07 PM |
| Berkman Charles S | VP, Gen. Counsel & Secretary | Aug 30, 2013 | Option Exercise | $17.51 | 37,331 | 653,697 | 29,732 | Sep 04, 2013, 07:10 PM |
| Berkman Charles S | VP, Gen. Counsel & Secretary | Aug 30, 2013 | Sale | $47.54 | 28,323 | 1,346,456 | 17,928 | Sep 04, 2013, 07:10 PM |
| Sharp John P | VP Finance and CFO | Aug 16, 2013 | Option Exercise | $9.96 | 7,500 | 74,700 | 31,666 | Aug 20, 2013, 06:44 PM |
| Sharp John P | VP Finance and CFO | Aug 16, 2013 | Sale | $42.75 | 7,500 | 320,619 | 24,166 | Aug 20, 2013, 06:44 PM |
| Berkman Charles S | VP, Gen. Counsel & Secretary | Aug 19, 2013 | Option Exercise | $10.05 | 4,284 | 43,054 | 17,928 | Aug 20, 2013, 06:44 PM |
| Berkman Charles S | VP, Gen. Counsel & Secretary | Aug 16, 2013 | Option Exercise | $9.96 | 14,583 | 145,247 | 28,227 | Aug 20, 2013, 06:44 PM |
| Berkman Charles S | VP, Gen. Counsel & Secretary | Aug 16, 2013 | Sale | $42.63 | 14,583 | 621,732 | 13,644 | Aug 20, 2013, 06:44 PM |
| HIGGINS JOHN L | President & CEO | Aug 19, 2013 | Option Exercise | $16.14 | 6,556 | 105,814 | 116,581 | Aug 20, 2013, 06:44 PM |
| HIGGINS JOHN L | President & CEO | Aug 16, 2013 | Sale | $42.85 | 10,000 | 428,500 | 110,025 | Aug 20, 2013, 06:44 PM |
| DeSilva Nishan M | VP, Corporate Development | Jun 28, 2013 | Buy | $17.36 | 169 | 2,934 | 15,659 | Jul 01, 2013, 03:27 PM |
| FOEHR MATTHEW W | EVP and COO | Jun 28, 2013 | Buy | $17.36 | 1,059 | 18,384 | 44,929 | Jul 01, 2013, 03:27 PM |
| Berkman Charles S | VP, Gen. Counsel & Secretary | Jun 28, 2013 | Buy | $17.36 | 815 | 14,148 | 13,644 | Jul 01, 2013, 03:26 PM |
| Berkman Charles S | VP, Gen. Counsel & Secretary | May 10, 2013 | Sale | $26.66 | 4,000 | 106,640 | 12,829 | May 13, 2013, 06:46 PM |
| BVF PARTNERS L P/IL | 10% Owner | Jan 23, 2013 | Buy | $19.78 | 39,600 | 783,181 | 2,163,412 | Jan 25, 2013, 05:17 PM |
| DeSilva Nishan M | VP, Corporate Development | Dec 31, 2012 | Option Exercise | $14.53 | 490 | 7,122 | 10,490 | Jan 03, 2013, 08:27 PM |
| KOZARICH JOHN W | Director | Dec 21, 2012 | Option Exercise | $12.06 | 3,333 | 40,196 | 36,948 | Dec 21, 2012, 05:51 PM |
| BVF PARTNERS L P/IL | 10% Owner | Dec 14, 2012 | Buy | $18.63 | 5,386 | 100,365 | 2,123,812 | Dec 18, 2012, 04:36 PM |
| BVF PARTNERS L P/IL | 10% Owner | Dec 06, 2012 | Buy | $17.94 | 50,100 | 898,959 | 2,118,426 | Dec 10, 2012, 04:40 PM |
| FOEHR MATTHEW W | EVP and COO | Dec 05, 2012 | Buy | $17.99 | 370 | 6,656 | 37,870 | Dec 05, 2012, 04:53 PM |
| HIGGINS JOHN L | President & CEO | Dec 05, 2012 | Buy | $18.03 | 2,000 | 36,060 | 112,025 | Dec 05, 2012, 04:53 PM |
| KNOTT DAVID M | Director | Nov 30, 2012 | Sale | $19.71 | 6,652 | 131,111 | 211,396 | Dec 03, 2012, 02:13 PM |
| KNOTT DAVID M | Director | Nov 29, 2012 | Sale | $20.00 | 13,348 | 266,960 | 218,048 | Dec 03, 2012, 02:13 PM |
| KNOTT DAVID M | Director | Nov 27, 2012 | Sale | $19.55 | 65,000 | 1,270,750 | 266,396 | Nov 29, 2012, 03:04 PM |
| KNOTT DAVID M | Director | Nov 28, 2012 | Sale | $19.51 | 35,000 | 682,850 | 231,396 | Nov 29, 2012, 03:04 PM |
| BVF PARTNERS L P/IL | 10% Owner | Oct 31, 2012 | Buy | $14.99 | 4,076 | 61,096 | 741,627 | Nov 19, 2012, 05:24 PM |
| BVF PARTNERS L P/IL | 10% Owner | Oct 26, 2012 | Buy | $15.26 | 12,515 | 190,926 | 737,551 | Nov 19, 2012, 05:24 PM |
| KNOTT DAVID M | Director | Aug 29, 2012 | Buy | $16.36 | 2,743 | 44,875 | 2,743 | Nov 15, 2012, 06:11 PM |
| BVF PARTNERS L P/IL | 10% Owner | Oct 31, 2012 | Buy | $14.99 | 4,076 | 61,096 | 741,627 | Nov 02, 2012, 06:36 PM |
| BVF PARTNERS L P/IL | 10% Owner | Oct 26, 2012 | Buy | $15.26 | 12,515 | 190,926 | 737,551 | Nov 02, 2012, 06:36 PM |
| Berkman Charles S | VP, Gen. Counsel & Secretary | Sep 07, 2012 | Sale | $18.77 | 4,249 | 79,754 | 14,329 | Sep 10, 2012, 01:55 PM |
| HIGGINS JOHN L | President & CEO | Aug 13, 2012 | Buy | $16.39 | 500 | 8,195 | 110,025 | Aug 14, 2012, 07:19 PM |
| HIGGINS JOHN L | President & CEO | Jun 29, 2012 | Option Exercise | $10.12 | 1,250 | 12,654 | 109,525 | Jul 03, 2012, 05:47 PM |
| FOEHR MATTHEW W | EVP and COO | Jun 29, 2012 | Option Exercise | $10.12 | 1,250 | 12,654 | 37,500 | Jul 03, 2012, 05:46 PM |
| Berkman Charles S | VP, Gen. Counsel & Secretary | Jun 29, 2012 | Option Exercise | $10.12 | 1,250 | 12,654 | 18,578 | Jul 03, 2012, 05:46 PM |
| Aryeh Jason | Director | Jun 01, 2012 | Buy | $11.98 | 700 | 8,386 | 285,036 | Jun 05, 2012, 12:56 PM |
| Sabba Stephen L | Director | Jun 01, 2012 | Option Exercise | $12.02 | 2,000 | 24,040 | 17,425 | Jun 04, 2012, 08:28 PM |
| KNOTT DAVID M | Director | May 24, 2012 | Buy | $11.62 | 23,900 | 277,718 | 264,661 | May 25, 2012, 01:50 PM |
| KNOTT DAVID M | Director | May 24, 2012 | Buy | $11.62 | 172,100 | 1,999,802 | 972,100 | May 25, 2012, 01:50 PM |
| KNOTT DAVID M | Director | May 24, 2012 | Sale | $11.62 | 76,167 | 885,061 | 331,396 | May 25, 2012, 01:50 PM |
| KNOTT DAVID M | Director | May 24, 2012 | Sale | $11.62 | 98,633 | 1,146,115 | 0 | May 25, 2012, 01:50 PM |
| KNOTT DAVID M | Director | May 24, 2012 | Sale | $11.62 | 21,200 | 246,344 | 41,583 | May 25, 2012, 01:50 PM |
| Patel Sunil | Director | May 23, 2012 | Buy | $11.38 | 1,500 | 17,070 | 29,705 | May 24, 2012, 02:01 PM |
| HIGGINS JOHN L | President & CEO | May 04, 2012 | Buy | $12.04 | 1,000 | 12,040 | 108,275 | May 08, 2012, 01:54 PM |
| Berkman Charles S | VP, Gen. Counsel & Secretary | Mar 08, 2012 | Sale | $15.76 | 3,606 | 56,832 | 17,434 | Mar 08, 2012, 06:24 PM |
| HIGGINS JOHN L | President & CEO | Dec 30, 2011 | Option Exercise | $10.09 | 210 | 2,119 | 89,275 | Jan 06, 2012, 05:21 PM |
| FOEHR MATTHEW W | EVP and COO | Dec 30, 2011 | Option Exercise | $10.09 | 1,250 | 12,612 | 26,250 | Jan 06, 2012, 05:20 PM |
| Berkman Charles S | VP, Gen. Counsel & Secretary | Dec 30, 2011 | Option Exercise | $10.09 | 1,238 | 12,491 | 15,934 | Jan 06, 2012, 05:19 PM |
| BVF PARTNERS L P/IL | 10% Owner | Nov 21, 2011 | Buy | $10.59 | 340,200 | 3,602,718 | 2,068,326 | Nov 22, 2011, 04:29 PM |
| BVF PARTNERS L P/IL | 10% Owner | Nov 21, 2011 | Buy | $10.59 | 98,171 | 1,039,631 | 725,036 | Nov 22, 2011, 04:29 PM |
| BVF PARTNERS L P/IL | 10% Owner | Nov 18, 2011 | Buy | $11.01 | 72,669 | 799,795 | 1,788,226 | Nov 22, 2011, 04:29 PM |
| KOZARICH JOHN W | Director | Nov 11, 2011 | Buy | $11.79 | 1,000 | 11,787 | 27,098 | Nov 14, 2011, 07:00 PM |
| Sabba Stephen L | Director | Nov 14, 2011 | Buy | $11.50 | 1,000 | 11,500 | 12,704 | Nov 14, 2011, 06:31 PM |
| Sabba Stephen L | Director | Nov 10, 2011 | Buy | $11.69 | 1,000 | 11,690 | 11,704 | Nov 14, 2011, 06:31 PM |
| KNOTT DAVID M | Director | Nov 10, 2011 | Buy | $11.58 | 4,000 | 46,320 | 54,704 | Nov 14, 2011, 06:29 PM |
| Aryeh Jason | Director | Nov 10, 2011 | Buy | $10.90 | 1,000 | 10,900 | 5,025 | Nov 10, 2011, 07:28 PM |
| Aryeh Jason | Director | Nov 10, 2011 | Buy | $11.01 | 1,000 | 11,010 | 284,336 | Nov 10, 2011, 07:28 PM |
| Patel Sunil | Director | Nov 10, 2011 | Buy | $11.11 | 2,500 | 27,774 | 28,205 | Nov 10, 2011, 07:20 PM |
| BVF PARTNERS L P/IL | 10% Owner | Oct 26, 2011 | Buy | $13.91 | 6,020 | 83,751 | 1,741,800 | Oct 28, 2011, 04:55 PM |
| BVF PARTNERS L P/IL | 10% Owner | Oct 21, 2011 | Buy | $13.93 | 4,600 | 64,062 | 1,738,000 | Oct 25, 2011, 04:22 PM |
| BVF PARTNERS L P/IL | 10% Owner | Oct 18, 2011 | Buy | $13.73 | 2,200 | 30,215 | 1,727,400 | Oct 20, 2011, 05:40 PM |
| BVF PARTNERS L P/IL | 10% Owner | Oct 20, 2011 | Buy | $13.93 | 11,900 | 165,809 | 1,735,000 | Oct 20, 2011, 05:40 PM |
| BVF PARTNERS L P/IL | 10% Owner | Oct 13, 2011 | Buy | $13.55 | 17,258 | 233,880 | 1,726,000 | Oct 14, 2011, 04:16 PM |
| BVF PARTNERS L P/IL | 10% Owner | Oct 13, 2011 | Buy | $13.55 | 4,995 | 67,692 | 605,053 | Oct 14, 2011, 04:16 PM |
| BVF PARTNERS L P/IL | 10% Owner | Oct 12, 2011 | Buy | $13.69 | 53,100 | 726,992 | 1,711,762 | Oct 14, 2011, 04:16 PM |
| BVF PARTNERS L P/IL | 10% Owner | Oct 04, 2011 | Buy | $12.78 | 14,400 | 183,961 | 1,675,562 | Oct 06, 2011, 05:02 PM |
| KNOTT DAVID M | Director | Sep 01, 2011 | Buy | $15.21 | 1,500 | 22,815 | 240,761 | Sep 06, 2011, 04:59 PM |
| KNOTT DAVID M | Director | Sep 01, 2011 | Buy | $15.21 | 5,320 | 80,917 | 800,000 | Sep 06, 2011, 04:59 PM |
| KNOTT DAVID M | Director | Sep 01, 2011 | Buy | $15.21 | 2,480 | 37,721 | 407,563 | Sep 06, 2011, 04:59 PM |
| KNOTT DAVID M | Director | Sep 01, 2011 | Buy | $15.21 | 700 | 10,647 | 98,633 | Sep 06, 2011, 04:59 PM |
| KNOTT DAVID M | Director | Aug 30, 2011 | Buy | $14.83 | 1,640 | 24,321 | 404,483 | Sep 01, 2011, 01:26 PM |
| KNOTT DAVID M | Director | Aug 30, 2011 | Buy | $14.83 | 700 | 10,381 | 97,733 | Sep 01, 2011, 01:26 PM |
| KNOTT DAVID M | Director | Aug 30, 2011 | Buy | $14.83 | 1,400 | 20,762 | 238,761 | Sep 01, 2011, 01:26 PM |
| KNOTT DAVID M | Director | Aug 31, 2011 | Buy | $14.94 | 600 | 8,964 | 405,083 | Sep 01, 2011, 01:26 PM |
| KNOTT DAVID M | Director | Aug 30, 2011 | Buy | $14.83 | 5,200 | 77,116 | 792,980 | Sep 01, 2011, 01:26 PM |
| KNOTT DAVID M | Director | Aug 31, 2011 | Buy | $14.94 | 200 | 2,988 | 97,933 | Sep 01, 2011, 01:26 PM |
| KNOTT DAVID M | Director | Aug 31, 2011 | Buy | $14.94 | 500 | 7,470 | 239,261 | Sep 01, 2011, 01:26 PM |
| KNOTT DAVID M | Director | Aug 31, 2011 | Buy | $14.94 | 1,700 | 25,398 | 794,680 | Sep 01, 2011, 01:26 PM |
| KNOTT DAVID M | Director | Aug 29, 2011 | Buy | $14.21 | 10,400 | 147,784 | 787,780 | Aug 30, 2011, 05:00 PM |
| KNOTT DAVID M | Director | Aug 26, 2011 | Buy | $12.54 | 11,159 | 139,934 | 397,543 | Aug 30, 2011, 05:00 PM |
| KNOTT DAVID M | Director | Aug 26, 2011 | Buy | $12.54 | 2,600 | 32,604 | 95,833 | Aug 30, 2011, 05:00 PM |
| KNOTT DAVID M | Director | Aug 26, 2011 | Buy | $12.54 | 6,600 | 82,764 | 234,261 | Aug 30, 2011, 05:00 PM |
| KNOTT DAVID M | Director | Aug 29, 2011 | Buy | $14.21 | 5,300 | 75,313 | 402,843 | Aug 30, 2011, 05:00 PM |
| KNOTT DAVID M | Director | Aug 26, 2011 | Buy | $12.54 | 21,200 | 265,848 | 777,380 | Aug 30, 2011, 05:00 PM |
| KNOTT DAVID M | Director | Aug 29, 2011 | Buy | $14.21 | 1,200 | 17,052 | 97,033 | Aug 30, 2011, 05:00 PM |
| KNOTT DAVID M | Director | Aug 29, 2011 | Buy | $14.21 | 3,100 | 44,051 | 237,361 | Aug 30, 2011, 05:00 PM |
| KNOTT DAVID M | Director | Aug 25, 2011 | Buy | $12.57 | 9,900 | 124,443 | 386,384 | Aug 26, 2011, 05:48 PM |
| KNOTT DAVID M | Director | Aug 25, 2011 | Buy | $12.57 | 2,500 | 31,425 | 93,233 | Aug 26, 2011, 05:48 PM |
| KNOTT DAVID M | Director | Aug 25, 2011 | Buy | $12.57 | 5,800 | 72,906 | 227,661 | Aug 26, 2011, 05:48 PM |
| KNOTT DAVID M | Director | Aug 25, 2011 | Buy | $12.57 | 19,600 | 246,372 | 756,180 | Aug 26, 2011, 05:48 PM |
| KNOTT DAVID M | Director | Aug 25, 2011 | Buy | $12.57 | 17,200 | 216,204 | 62,783 | Aug 26, 2011, 05:48 PM |
| KNOTT DAVID M | Director | Aug 24, 2011 | Buy | $12.95 | 4,000 | 51,800 | 376,484 | Aug 25, 2011, 04:41 PM |
| KNOTT DAVID M | Director | Aug 23, 2011 | Buy | $12.18 | 10,300 | 125,454 | 729,080 | Aug 25, 2011, 04:41 PM |
| KNOTT DAVID M | Director | Aug 24, 2011 | Buy | $12.95 | 900 | 11,655 | 90,733 | Aug 25, 2011, 04:41 PM |
| KNOTT DAVID M | Director | Aug 24, 2011 | Buy | $12.95 | 2,390 | 30,950 | 221,861 | Aug 25, 2011, 04:41 PM |
| KNOTT DAVID M | Director | Aug 24, 2011 | Buy | $12.95 | 7,500 | 97,125 | 736,580 | Aug 25, 2011, 04:41 PM |
| KNOTT DAVID M | Director | Aug 23, 2011 | Buy | $12.18 | 5,400 | 65,772 | 372,484 | Aug 25, 2011, 04:41 PM |
| KNOTT DAVID M | Director | Aug 24, 2011 | Buy | $12.95 | 2,600 | 33,670 | 28,300 | Aug 25, 2011, 04:41 PM |
| KNOTT DAVID M | Director | Aug 23, 2011 | Buy | $12.18 | 1,200 | 14,616 | 89,833 | Aug 25, 2011, 04:41 PM |
| KNOTT DAVID M | Director | Aug 24, 2011 | Buy | $12.95 | 4,100 | 53,095 | 45,583 | Aug 25, 2011, 04:41 PM |
| KNOTT DAVID M | Director | Aug 23, 2011 | Buy | $12.18 | 3,100 | 37,758 | 219,471 | Aug 25, 2011, 04:41 PM |
| KNOTT DAVID M | Director | Aug 19, 2011 | Buy | $11.96 | 4,300 | 51,428 | 215,871 | Aug 24, 2011, 06:16 AM |
| KNOTT DAVID M | Director | Aug 19, 2011 | Buy | $11.96 | 14,300 | 171,028 | 717,080 | Aug 24, 2011, 06:16 AM |
| KNOTT DAVID M | Director | Aug 22, 2011 | Buy | $12.00 | 1,069 | 12,828 | 367,084 | Aug 24, 2011, 06:16 AM |
| KNOTT DAVID M | Director | Aug 22, 2011 | Buy | $12.00 | 200 | 2,400 | 88,633 | Aug 24, 2011, 06:16 AM |
| KNOTT DAVID M | Director | Aug 22, 2011 | Buy | $12.00 | 500 | 6,000 | 216,371 | Aug 24, 2011, 06:16 AM |
| KNOTT DAVID M | Director | Aug 22, 2011 | Buy | $12.00 | 1,700 | 20,400 | 718,780 | Aug 24, 2011, 06:16 AM |
| KNOTT DAVID M | Director | Aug 19, 2011 | Buy | $11.96 | 7,400 | 88,504 | 366,015 | Aug 24, 2011, 06:16 AM |
| KNOTT DAVID M | Director | Aug 19, 2011 | Buy | $11.96 | 1,800 | 21,528 | 88,433 | Aug 24, 2011, 06:16 AM |
| BVF PARTNERS L P/IL | 10% Owner | Aug 19, 2011 | Buy | $11.93 | 21,300 | 254,020 | 1,671,562 | Aug 22, 2011, 06:05 PM |
| BVF PARTNERS L P/IL | 10% Owner | Aug 18, 2011 | Buy | $11.91 | 16,571 | 197,371 | 1,652,562 | Aug 22, 2011, 06:05 PM |
| KNOTT DAVID M | Director | Aug 18, 2011 | Buy | $11.91 | 2,500 | 29,775 | 211,571 | Aug 19, 2011, 03:49 PM |
| KNOTT DAVID M | Director | Aug 18, 2011 | Buy | $11.91 | 8,400 | 100,044 | 702,780 | Aug 19, 2011, 03:49 PM |
| KNOTT DAVID M | Director | Aug 17, 2011 | Buy | $12.35 | 2,133 | 26,343 | 354,515 | Aug 19, 2011, 03:49 PM |
| KNOTT DAVID M | Director | Aug 17, 2011 | Buy | $12.35 | 600 | 7,410 | 85,633 | Aug 19, 2011, 03:49 PM |
| KNOTT DAVID M | Director | Aug 17, 2011 | Buy | $12.35 | 1,200 | 14,820 | 209,071 | Aug 19, 2011, 03:49 PM |
| KNOTT DAVID M | Director | Aug 18, 2011 | Buy | $11.91 | 4,100 | 48,831 | 358,615 | Aug 19, 2011, 03:49 PM |
| KNOTT DAVID M | Director | Aug 17, 2011 | Buy | $12.35 | 4,200 | 51,870 | 694,380 | Aug 19, 2011, 03:49 PM |
| KNOTT DAVID M | Director | Aug 18, 2011 | Buy | $11.91 | 1,000 | 11,910 | 86,633 | Aug 19, 2011, 03:49 PM |
| BVF PARTNERS L P/IL | 10% Owner | Aug 11, 2011 | Buy | $11.19 | 1,394 | 15,601 | 1,636,862 | Aug 15, 2011, 06:24 PM |
| KNOTT DAVID M | Director | Aug 15, 2011 | Buy | $11.97 | 700 | 8,379 | 207,871 | Aug 15, 2011, 06:00 PM |
| KNOTT DAVID M | Director | Aug 15, 2011 | Buy | $11.97 | 2,400 | 28,728 | 690,180 | Aug 15, 2011, 06:00 PM |
| KNOTT DAVID M | Director | Aug 12, 2011 | Buy | $11.99 | 3,448 | 41,342 | 351,182 | Aug 15, 2011, 06:00 PM |
| KNOTT DAVID M | Director | Aug 12, 2011 | Buy | $11.99 | 800 | 9,592 | 84,733 | Aug 15, 2011, 06:00 PM |
| KNOTT DAVID M | Director | Aug 12, 2011 | Buy | $11.99 | 2,200 | 26,378 | 207,171 | Aug 15, 2011, 06:00 PM |
| KNOTT DAVID M | Director | Aug 15, 2011 | Buy | $11.97 | 1,200 | 14,364 | 352,382 | Aug 15, 2011, 06:00 PM |
| KNOTT DAVID M | Director | Aug 12, 2011 | Buy | $11.99 | 7,300 | 87,527 | 687,780 | Aug 15, 2011, 06:00 PM |
| KNOTT DAVID M | Director | Aug 15, 2011 | Buy | $11.97 | 300 | 3,591 | 85,033 | Aug 15, 2011, 06:00 PM |
| KNOTT DAVID M | Director | Aug 10, 2011 | Buy | $10.80 | 7,400 | 79,920 | 82,433 | Aug 12, 2011, 04:13 PM |
| KNOTT DAVID M | Director | Aug 11, 2011 | Buy | $11.45 | 1,900 | 21,755 | 347,734 | Aug 12, 2011, 04:13 PM |
| KNOTT DAVID M | Director | Aug 10, 2011 | Buy | $10.80 | 24,500 | 264,600 | 201,071 | Aug 12, 2011, 04:13 PM |
| KNOTT DAVID M | Director | Aug 11, 2011 | Buy | $11.45 | 1,500 | 17,175 | 83,933 | Aug 12, 2011, 04:13 PM |
| KNOTT DAVID M | Director | Aug 10, 2011 | Buy | $10.80 | 80,600 | 870,480 | 667,780 | Aug 12, 2011, 04:13 PM |
| KNOTT DAVID M | Director | Aug 11, 2011 | Buy | $11.45 | 3,900 | 44,655 | 204,971 | Aug 12, 2011, 04:13 PM |
| KNOTT DAVID M | Director | Aug 11, 2011 | Buy | $11.45 | 12,700 | 145,415 | 680,480 | Aug 12, 2011, 04:13 PM |
| KNOTT DAVID M | Director | Aug 10, 2011 | Buy | $10.80 | 5,600 | 60,480 | 25,700 | Aug 12, 2011, 04:13 PM |
| KNOTT DAVID M | Director | Aug 10, 2011 | Buy | $10.80 | 6,900 | 74,520 | 41,483 | Aug 12, 2011, 04:13 PM |
| Davis Todd C | Director | Aug 10, 2011 | Buy | $10.90 | 15,000 | 163,500 | 29,201 | Aug 11, 2011, 08:08 PM |
| Patel Sunil | Director | Aug 10, 2011 | Buy | $10.74 | 5,000 | 53,705 | 25,705 | Aug 11, 2011, 06:00 PM |
| Aryeh Jason | Director | Aug 10, 2011 | Buy | $10.57 | 2,000 | 21,140 | 283,336 | Aug 11, 2011, 02:20 PM |
| BVF PARTNERS L P/IL | 10% Owner | Aug 09, 2011 | Buy | $10.86 | 133,000 | 1,444,912 | 1,487,736 | Aug 10, 2011, 06:28 PM |
| BVF PARTNERS L P/IL | 10% Owner | Aug 09, 2011 | Buy | $10.86 | 57,900 | 629,026 | 527,236 | Aug 10, 2011, 06:28 PM |
| BVF PARTNERS L P/IL | 10% Owner | Aug 08, 2011 | Buy | $11.20 | 175,800 | 1,969,663 | 1,354,736 | Aug 10, 2011, 06:28 PM |
| BVF PARTNERS L P/IL | 10% Owner | Aug 10, 2011 | Buy | $10.91 | 233,000 | 2,542,659 | 1,635,936 | Aug 10, 2011, 06:28 PM |
| HIGGINS JOHN L | President & CEO | Jun 30, 2011 | Option Exercise | $7.64 | 277 | 2,116 | 89,065 | Jul 26, 2011, 06:02 PM |
| HIGGINS JOHN L | President & CEO | Dec 31, 2010 | Option Exercise | $7.14 | 294 | 2,099 | 73,788 | Jul 26, 2011, 06:02 PM |
| Aryeh Jason | Director | May 12, 2011 | Buy | $10.96 | 1,725 | 18,906 | 281,336 | May 13, 2011, 05:45 PM |
| Aryeh Jason | Director | Mar 11, 2011 | Buy | $9.83 | 1,000 | 9,830 | 3,025 | May 13, 2011, 05:41 PM |
| Aryeh Jason | Director | Mar 11, 2011 | Buy | $9.84 | 3,000 | 29,525 | 270,111 | May 13, 2011, 05:41 PM |
| Aryeh Jason | Director | Mar 16, 2011 | Buy | $9.35 | 4,000 | 37,405 | 276,611 | Mar 16, 2011, 07:14 PM |
| Aryeh Jason | Director | Mar 15, 2011 | Buy | $9.49 | 1,500 | 14,235 | 272,611 | Mar 16, 2011, 07:14 PM |
| Aryeh Jason | Director | Mar 14, 2011 | Buy | $9.69 | 3,500 | 33,900 | 271,111 | Mar 15, 2011, 01:22 PM |
| LAMATTINA JOHN L | Director | Mar 11, 2011 | Buy | $9.80 | 10,000 | 98,030 | 11,666 | Mar 14, 2011, 04:12 PM |
| Aryeh Jason | Director | Mar 10, 2011 | Buy | $10.05 | 1,000 | 10,045 | 3,025 | Mar 14, 2011, 03:24 PM |
| Aryeh Jason | Director | Mar 10, 2011 | Buy | $10.16 | 500 | 5,080 | 267,611 | Mar 14, 2011, 03:24 PM |
| KNOTT DAVID M | Director | Mar 03, 2011 | Buy | $11.02 | 13,400 | 147,668 | 20,100 | Mar 07, 2011, 05:45 PM |
| KNOTT DAVID M | Director | Mar 03, 2011 | Buy | $11.02 | 23,000 | 253,460 | 34,583 | Mar 07, 2011, 05:45 PM |
| KNOTT DAVID M | Director | Mar 03, 2011 | Buy | $11.02 | 1,000 | 11,020 | 1,666 | Mar 07, 2011, 05:45 PM |
| KOZARICH JOHN W | Director | Feb 25, 2011 | Buy | $9.99 | 1,789 | 17,872 | 18,726 | Mar 03, 2011, 01:59 PM |
| KOZARICH JOHN W | Director | Feb 24, 2011 | Buy | $9.98 | 3,211 | 32,056 | 16,937 | Mar 03, 2011, 01:59 PM |
| Kazmi Syed | VP, Bus. Dev. & Strategic Plan | Feb 28, 2011 | Sale | $10.69 | 1,166 | 12,459 | 15,296 | Mar 01, 2011, 03:06 PM |
| KOZARICH JOHN W | Director | Feb 25, 2011 | Option Exercise | $9.99 | 1,789 | 17,872 | 18,726 | Feb 28, 2011, 07:05 PM |
| KOZARICH JOHN W | Director | Feb 24, 2011 | Option Exercise | $9.98 | 3,211 | 32,056 | 16,937 | Feb 28, 2011, 07:05 PM |
| KNOTT DAVID M | Director | Feb 25, 2011 | Buy | $10.02 | 14,432 | 144,609 | 33,248 | Feb 28, 2011, 04:19 PM |
| KNOTT DAVID M | Director | Feb 24, 2011 | Buy | $9.99 | 16,316 | 162,997 | 18,816 | Feb 28, 2011, 04:19 PM |
| KNOTT DAVID M | Director | Feb 28, 2011 | Buy | $10.84 | 9,252 | 100,292 | 42,500 | Feb 28, 2011, 04:19 PM |
| KNOTT DAVID M | Director | Feb 23, 2011 | Buy | $9.95 | 21,400 | 212,930 | 75,033 | Feb 25, 2011, 01:46 PM |
| KNOTT DAVID M | Director | Feb 23, 2011 | Buy | $9.95 | 2,200 | 21,890 | 176,571 | Feb 25, 2011, 01:46 PM |
| KNOTT DAVID M | Director | Feb 23, 2011 | Buy | $9.95 | 65,200 | 648,740 | 587,180 | Feb 25, 2011, 01:46 PM |
| KNOTT DAVID M | Director | Feb 23, 2011 | Buy | $9.99 | 6,700 | 66,933 | 6,700 | Feb 25, 2011, 01:46 PM |
| KNOTT DAVID M | Director | Feb 23, 2011 | Sale | $9.95 | 47,087 | 468,516 | 345,834 | Feb 25, 2011, 01:46 PM |
| KNOTT DAVID M | Director | Feb 23, 2011 | Sale | $9.95 | 31,331 | 311,743 | 0 | Feb 25, 2011, 01:46 PM |
| KNOTT DAVID M | Director | Feb 23, 2011 | Sale | $9.95 | 10,382 | 103,301 | 0 | Feb 25, 2011, 01:46 PM |
| Aryeh Jason | Director | Feb 23, 2011 | Buy | $9.94 | 5,000 | 49,700 | 267,111 | Feb 23, 2011, 05:02 PM |
| Berkman Charles S | VP, Gen. Counsel & Secretary | Feb 16, 2011 | Sale | $9.75 | 5,000 | 48,751 | 11,696 | Feb 18, 2011, 05:38 PM |
| KOZARICH JOHN W | Director | Feb 17, 2011 | Buy | $9.90 | 1,000 | 9,900 | 13,726 | Feb 17, 2011, 06:07 PM |
| Patel Sunil | Director | Feb 16, 2011 | Buy | $9.22 | 10,000 | 92,174 | 13,333 | Feb 17, 2011, 01:57 PM |
| KOZARICH JOHN W | Director | Nov 11, 2010 | Buy | $1.60 | 10,000 | 15,954 | 76,357 | Nov 12, 2010, 02:03 PM |
Load More Insider Transactions
Buy
Sale
Option Exercise
| Owner | Relationship | Date | Value($) |
| Korenberg Matthew E | President & COO | 02/15/2023 | 210,912 |
| Espinoza Octavio | Chief Financial Officer | 02/15/2023 | 61,960 |
| Espinoza Octavio | Chief Financial Officer | 12/30/2022 | 15,614 |
| Korenberg Matthew E | President & COO | 12/28/2022 | 255,813 |
| HIGGINS JOHN L | Director | 12/28/2022 | 350,608 |
| HIGGINS JOHN L | Director | 12/16/2022 | 618,657 |
| HIGGINS JOHN L | Director | 12/12/2022 | 255,571 |
| HIGGINS JOHN L | Director | 12/12/2022 | 255,600 |
| Korenberg Matthew E | President & COO | 11/30/2022 | 261,930 |
| HIGGINS JOHN L | Chief Executive Officer | 11/30/2022 | 714,639 |
| Espinoza Octavio | Chief Financial Officer | 11/30/2022 | 86,532 |
| Reardon Andrew | See Remarks | 11/30/2022 | 78,222 |
| HIGGINS JOHN L | Chief Executive Officer | 11/18/2022 | 127,800 |
| HIGGINS JOHN L | Chief Executive Officer | 11/17/2022 | 783,173 |
| Espinoza Octavio | Chief Financial Officer | 11/09/2022 | 128,283 |
| HIGGINS JOHN L | Chief Executive Officer | 09/16/2022 | 88,060 |
| HIGGINS JOHN L | Chief Executive Officer | 09/16/2022 | 268,050 |
| HIGGINS JOHN L | Chief Executive Officer | 09/15/2022 | 180,000 |
| Korenberg Matthew E | EVP,Finance & Strategy and CFO | 06/30/2022 | 12,437 |
| HIGGINS JOHN L | Chief Executive Officer | 06/30/2022 | 12,437 |
| FOEHR MATTHEW W | President and COO | 05/13/2022 | 206,910 |
| HIGGINS JOHN L | Chief Executive Officer | 05/09/2022 | 175,360 |
| FOEHR MATTHEW W | President and COO | 02/15/2022 | 438,569 |
| HIGGINS JOHN L | Chief Executive Officer | 02/15/2022 | 732,557 |
| Korenberg Matthew E | EVP,Finance & Strategy and CFO | 02/15/2022 | 421,378 |
| Korenberg Matthew E | EVP,Finance & Strategy and CFO | 01/26/2022 | 412,431 |
| HIGGINS JOHN L | Chief Executive Officer | 01/26/2022 | 1,050,744 |
| Berkman Charles S | SVP, Gen. Counsel & Secretary | 01/26/2022 | 245,094 |
| FOEHR MATTHEW W | President and COO | 01/26/2022 | 582,610 |
| LAMATTINA JOHN L | Director | 11/16/2021 | 156,170 |
| LAMATTINA JOHN L | Director | 11/16/2021 | 782,579 |
| HIGGINS JOHN L | Chief Executive Officer | 11/12/2021 | 481,500 |
| FOEHR MATTHEW W | President and COO | 11/11/2021 | 347,818 |
| FOEHR MATTHEW W | President and COO | 11/11/2021 | 1,819,259 |
| FOEHR MATTHEW W | President and COO | 08/04/2021 | 291,745 |
| FOEHR MATTHEW W | President and COO | 08/04/2021 | 969,509 |
| HIGGINS JOHN L | Chief Executive Officer | 06/30/2021 | 21,220 |
| Korenberg Matthew E | EVP,Finance & Strategy and CFO | 06/30/2021 | 21,220 |
| KOZARICH JOHN W | Director | 05/11/2021 | 50,267 |
| KOZARICH JOHN W | Director | 05/11/2021 | 48,930 |
| KOZARICH JOHN W | Director | 02/22/2021 | 25,300 |
| Berkman Charles S | SVP, Gen. Counsel & Secretary | 02/15/2021 | 175,047 |
| FOEHR MATTHEW W | President and COO | 02/15/2021 | 534,281 |
| HIGGINS JOHN L | Chief Executive Officer | 02/15/2021 | 898,862 |
| Korenberg Matthew E | EVP,Finance & Strategy and CFO | 02/15/2021 | 398,210 |
| Davis Todd C | Director | 02/11/2021 | 484,681 |
| Davis Todd C | Director | 02/10/2021 | 1,083,411 |
| Sabba Stephen L | Director | 02/09/2021 | 166,138 |
| Sabba Stephen L | Director | 02/09/2021 | 3,059,123 |
| HIGGINS JOHN L | Chief Executive Officer | 02/05/2021 | 602,999 |
| HIGGINS JOHN L | Chief Executive Officer | 02/05/2021 | 1,394,017 |
| HIGGINS JOHN L | Chief Executive Officer | 02/05/2021 | 11,119,228 |
| Berkman Charles S | SVP, Gen. Counsel & Secretary | 02/04/2021 | 3,230,369 |
| FOEHR MATTHEW W | President and COO | 02/04/2021 | 1,050,890 |
| FOEHR MATTHEW W | President and COO | 02/04/2021 | 7,878,582 |
| HIGGINS JOHN L | Chief Executive Officer | 01/25/2021 | 1,160,870 |
| HIGGINS JOHN L | Chief Executive Officer | 01/25/2021 | 723,500 |
| HIGGINS JOHN L | Chief Executive Officer | 01/27/2021 | 1,236,400 |
| HIGGINS JOHN L | Chief Executive Officer | 01/27/2021 | 7,280,000 |
| HIGGINS JOHN L | Chief Executive Officer | 01/25/2021 | 7,950,000 |
| FOEHR MATTHEW W | President and COO | 01/25/2021 | 518,733 |
| Korenberg Matthew E | EVP,Finance & Strategy and CFO | 01/25/2021 | 329,337 |
| Berkman Charles S | SVP, Gen. Counsel & Secretary | 01/25/2021 | 208,943 |
| Davis Todd C | Director | 01/27/2021 | 278,756 |
| HIGGINS JOHN L | Chief Executive Officer | 12/31/2020 | 18,851 |
| HIGGINS JOHN L | Chief Executive Officer | 12/08/2020 | 147,296 |
| HIGGINS JOHN L | Chief Executive Officer | 12/08/2020 | 147,303 |
| HIGGINS JOHN L | Chief Executive Officer | 11/09/2020 | 200,991 |
| HIGGINS JOHN L | Chief Executive Officer | 11/09/2020 | 201,000 |
| Patel Sunil | Director | 11/02/2020 | 82,520 |
| FOEHR MATTHEW W | President and COO | 08/21/2020 | 163,338 |
| FOEHR MATTHEW W | President and COO | 08/24/2020 | 1,710 |
| FOEHR MATTHEW W | President and COO | 08/21/2020 | 815,544 |
| FOEHR MATTHEW W | President and COO | 08/24/2020 | 8,649 |
| HIGGINS JOHN L | Chief Executive Officer | 07/07/2020 | 302,098 |
| Berkman Charles S | SVP, Gen. Counsel & Secretary | 06/30/2020 | 21,189 |
| Korenberg Matthew E | EVP,Finance & Strategy and CFO | 06/30/2020 | 21,189 |
| Berkman Charles S | SVP, Gen. Counsel & Secretary | 06/04/2020 | 1,321,771 |
| Korenberg Matthew E | EVP,Finance & Strategy and CFO | 02/15/2019 | 140,923 |
| FOEHR MATTHEW W | President and COO | 02/15/2019 | 341,550 |
| HIGGINS JOHN L | Chief Executive Officer | 02/15/2019 | 594,269 |
| FOEHR MATTHEW W | President and COO | 03/13/2020 | 43,840 |
| FOEHR MATTHEW W | President and COO | 02/27/2020 | 141,941 |
| FOEHR MATTHEW W | President and COO | 02/27/2020 | 794,750 |
| HIGGINS JOHN L | Chief Executive Officer | 02/13/2020 | 479,261 |
| HIGGINS JOHN L | Chief Executive Officer | 02/15/2020 | 497,429 |
| HIGGINS JOHN L | Chief Executive Officer | 02/13/2020 | 479,325 |
| FOEHR MATTHEW W | President and COO | 02/15/2020 | 241,714 |
| FOEHR MATTHEW W | President and COO | 02/14/2020 | 104,546 |
| FOEHR MATTHEW W | President and COO | 02/13/2020 | 10,872 |
| FOEHR MATTHEW W | President and COO | 02/14/2020 | 692,467 |
| Berkman Charles S | SVP, Gen. Counsel & Secretary | 02/15/2020 | 85,660 |
| Korenberg Matthew E | EVP,Finance & Strategy and CFO | 12/20/2019 | 223,809 |
| Berkman Charles S | SVP, Gen. Counsel & Secretary | 12/20/2019 | 119,739 |
| FOEHR MATTHEW W | President and COO | 12/20/2019 | 386,849 |
| HIGGINS JOHN L | Chief Executive Officer | 12/20/2019 | 714,517 |
| FOEHR MATTHEW W | President and COO | 11/12/2019 | 21,942 |
| FOEHR MATTHEW W | President and COO | 09/05/2019 | 22,030 |
| Aryeh Jason | Director | 09/03/2019 | 65,258 |
| Korenberg Matthew E | EVP,Finance & Strategy and CFO | 09/03/2019 | 43,091 |
| FOEHR MATTHEW W | President and COO | 08/12/2019 | 25,493 |
| Aryeh Jason | Director | 08/05/2019 | 67,146 |
| Berkman Charles S | SVP, Gen. Counsel & Secretary | 08/05/2019 | 74,013 |
| Davis Todd C | Director | 08/02/2019 | 93,594 |
| LAMATTINA JOHN L | Director | 08/01/2019 | 80,958 |
| LAMATTINA JOHN L | Director | 08/01/2019 | 80,750 |
| Patel Sunil | Director | 08/02/2019 | 95,980 |
| Sabba Stephen L | Director | 07/31/2019 | 386,395 |
| HIGGINS JOHN L | Chief Executive Officer | 07/31/2019 | 176,582 |
| Aryeh Jason | Director | 07/29/2019 | 26,503 |
| Aryeh Jason | Director | 07/31/2019 | 70,122 |
| Aryeh Jason | Director | 07/30/2019 | 300,663 |
| Berkman Charles S | SVP, Gen. Counsel & Secretary | 06/28/2019 | 17,659 |
| Korenberg Matthew E | EVP,Finance & Strategy and CFO | 06/28/2019 | 17,659 |
| Aryeh Jason | Director | 06/11/2019 | 26,753 |
| FOEHR MATTHEW W | President and COO | 06/11/2019 | 22,008 |
| HIGGINS JOHN L | Chief Executive Officer | 05/31/2019 | 108,202 |
| Aryeh Jason | Director | 05/31/2019 | 54,255 |
| Aryeh Jason | Director | 05/30/2019 | 27,503 |
| Aryeh Jason | Director | 05/29/2019 | 27,753 |
| Aryeh Jason | Director | 05/20/2019 | 28,003 |
| Aryeh Jason | Director | 05/14/2019 | 28,128 |
| HIGGINS JOHN L | Chief Executive Officer | 05/14/2019 | 283,750 |
| KOZARICH JOHN W | Director | 05/14/2019 | 44,700 |
| KOZARICH JOHN W | Director | 05/14/2019 | 282,300 |
| FOEHR MATTHEW W | President and COO | 03/14/2019 | 148,493 |
| Aryeh Jason | Director | 03/13/2019 | 22,727 |
| HIGGINS JOHN L | Chief Executive Officer | 03/13/2019 | 285,725 |
| FOEHR MATTHEW W | President and COO | 01/23/2019 | 287,051 |
| HIGGINS JOHN L | Chief Executive Officer | 01/23/2019 | 756,192 |
| Korenberg Matthew E | EVP,Finance & Strategy and CFO | 01/23/2019 | 148,108 |
| Berkman Charles S | SVP, Gen. Counsel & Secretary | 01/10/2019 | 187,029 |
| HIGGINS JOHN L | Chief Executive Officer | 01/10/2019 | 545,371 |
| Berkman Charles S | SVP, Gen. Counsel & Secretary | 12/17/2018 | 74,528 |
| FOEHR MATTHEW W | President and COO | 12/12/2018 | 79,750 |
| Berkman Charles S | SVP, Gen. Counsel & Secretary | 10/24/2018 | 65,462 |
| Davis Todd C | Director | 10/12/2018 | 525,021 |
| Berkman Charles S | SVP, Gen. Counsel & Secretary | 10/11/2018 | 28,940 |
| Davis Todd C | Director | 10/08/2018 | 634,977 |
| KOZARICH JOHN W | Director | 10/01/2018 | 687,610 |
| FOEHR MATTHEW W | President and COO | 10/01/2018 | 194,457 |
| FOEHR MATTHEW W | President and COO | 10/01/2018 | 3,286,560 |
| Berkman Charles S | SVP, Gen. Counsel & Secretary | 09/17/2018 | 282,369 |
| Berkman Charles S | SVP, Gen. Counsel & Secretary | 09/17/2018 | 705,183 |
| Sabba Stephen L | Director | 09/04/2018 | 66,150 |
| Sabba Stephen L | Director | 09/04/2018 | 1,275,250 |
| FOEHR MATTHEW W | President and COO | 09/04/2018 | 184,049 |
| FOEHR MATTHEW W | President and COO | 09/04/2018 | 3,060,084 |
| Berkman Charles S | SVP, Gen. Counsel & Secretary | 09/04/2018 | 1,358,796 |
| Berkman Charles S | SVP, Gen. Counsel & Secretary | 09/04/2018 | 4,951,063 |
| LAMATTINA JOHN L | Director | 09/04/2018 | 41,788 |
| LAMATTINA JOHN L | Director | 09/04/2018 | 850,292 |
| HIGGINS JOHN L | Chief Executive Officer | 08/30/2018 | 903,875 |
| Korenberg Matthew E | EVP,Finance & Strategy and CFO | 08/29/2018 | 990,017 |
| Korenberg Matthew E | EVP,Finance & Strategy and CFO | 08/29/2018 | 4,712,058 |
| Aryeh Jason | Director | 08/17/2018 | 6,495,554 |
| Aryeh Jason | Director | 08/16/2018 | 264,600 |
| Davis Todd C | Director | 08/17/2018 | 758,497 |
| Davis Todd C | Director | 08/16/2018 | 1,399,506 |
| HIGGINS JOHN L | Chief Executive Officer | 08/17/2018 | 188,009 |
| HIGGINS JOHN L | Chief Executive Officer | 08/16/2018 | 43,511 |
| HIGGINS JOHN L | Chief Executive Officer | 08/17/2018 | 3,157,299 |
| HIGGINS JOHN L | Chief Executive Officer | 08/16/2018 | 5,190,263 |
| Patel Sunil | Director | 08/16/2018 | 451,058 |
| Patel Sunil | Director | 08/16/2018 | 10,150,825 |
| Korenberg Matthew E | EVP,Finance & Strategy and CFO | 08/06/2018 | 189,555 |
| KOZARICH JOHN W | Director | 07/02/2018 | 518,700 |
| Korenberg Matthew E | EVP,Finance & Strategy and CFO | 06/29/2018 | 21,210 |
| Berkman Charles S | SVP, Gen. Counsel & Secretary | 06/29/2018 | 21,210 |
| LAMATTINA JOHN L | Director | 06/04/2018 | 50,120 |
| LAMATTINA JOHN L | Director | 06/04/2018 | 778,040 |
| HIGGINS JOHN L | Chief Executive Officer | 05/15/2018 | 200,217 |
| HIGGINS JOHN L | Chief Executive Officer | 05/15/2018 | 2,232,491 |
| FOEHR MATTHEW W | President and COO | 05/10/2018 | 139,026 |
| FOEHR MATTHEW W | President and COO | 05/10/2018 | 1,488,687 |
| KOZARICH JOHN W | Director | 04/02/2018 | 401,063 |
| Sabba Stephen L | Director | 03/12/2018 | 112,414 |
| Aryeh Jason | Director | 03/09/2018 | 705,900 |
| Aryeh Jason | Director | 03/08/2018 | 612,094 |
| LAMATTINA JOHN L | Director | 03/05/2018 | 33,750 |
| LAMATTINA JOHN L | Director | 03/05/2018 | 536,605 |
| Korenberg Matthew E | EVP,Finance & Strategy and CFO | 03/06/2018 | 91,228 |
| Berkman Charles S | SVP, Gen. Counsel & Secretary | 03/06/2018 | 65,021 |
| HIGGINS JOHN L | Chief Executive Officer | 03/06/2018 | 494,624 |
| FOEHR MATTHEW W | President and COO | 03/06/2018 | 241,673 |
| Aryeh Jason | Director | 02/23/2018 | 529,635 |
| Davis Todd C | Director | 02/26/2018 | 742,535 |
| Davis Todd C | Director | 02/27/2018 | 1,873,711 |
| FOEHR MATTHEW W | President and COO | 02/23/2018 | 88,785 |
| FOEHR MATTHEW W | President and COO | 02/23/2018 | 832,823 |
| Berkman Charles S | SVP, Gen. Counsel & Secretary | 02/15/2018 | 162,838 |
| FOEHR MATTHEW W | President and COO | 02/15/2018 | 575,750 |
| HIGGINS JOHN L | Chief Executive Officer | 02/15/2018 | 981,118 |
| HIGGINS JOHN L | Chief Executive Officer | 02/15/2018 | 1,413,279 |
| Korenberg Matthew E | EVP,Finance & Strategy and CFO | 02/15/2018 | 106,882 |
| HIGGINS JOHN L | Chief Executive Officer | 01/24/2018 | 3,712,500 |
| HIGGINS JOHN L | Chief Executive Officer | 01/19/2018 | 262,259 |
| HIGGINS JOHN L | Chief Executive Officer | 01/19/2018 | 4,318,906 |
| KOZARICH JOHN W | Director | 01/10/2018 | 362,500 |
| Korenberg Matthew E | VP, Finance and CFO | 12/28/2017 | 212,150 |
| FOEHR MATTHEW W | President and COO | 12/28/2017 | 411,959 |
| HIGGINS JOHN L | Chief Executive Officer | 12/28/2017 | 720,893 |
| Berkman Charles S | VP, Gen. Counsel & Secretary | 12/28/2017 | 162,926 |
| Sabba Stephen L | Director | 12/20/2017 | 126,956 |
| Aryeh Jason | Director | 11/17/2017 | 3,421,368 |
| HIGGINS JOHN L | Chief Executive Officer | 11/17/2017 | 316,888 |
| LAMATTINA JOHN L | Director | 11/17/2017 | 40,480 |
| LAMATTINA JOHN L | Director | 11/17/2017 | 559,160 |
| KOZARICH JOHN W | Director | 11/16/2017 | 708,550 |
| Korenberg Matthew E | VP, Finance and CFO | 11/17/2017 | 935,510 |
| HIGGINS JOHN L | Chief Executive Officer | 11/16/2017 | 750,991 |
| HIGGINS JOHN L | Chief Executive Officer | 10/13/2017 | 249,462 |
| HIGGINS JOHN L | Chief Executive Officer | 10/13/2017 | 249,537 |
| HIGGINS JOHN L | Chief Executive Officer | 09/05/2017 | 105,000 |
| HIGGINS JOHN L | Chief Executive Officer | 09/05/2017 | 650,000 |
| Aryeh Jason | Director | 08/23/2017 | 255,980 |
| FOEHR MATTHEW W | President and COO | 08/09/2017 | 69,292 |
| FOEHR MATTHEW W | President and COO | 08/09/2017 | 777,823 |
| Berkman Charles S | VP, Gen. Counsel & Secretary | 08/09/2017 | 2,364,667 |
| HIGGINS JOHN L | Chief Executive Officer | 08/08/2017 | 115,143 |
| HIGGINS JOHN L | Chief Executive Officer | 08/08/2017 | 685,375 |
| Korenberg Matthew E | VP, Finance and CFO | 08/06/2017 | 74,335 |
| Berkman Charles S | VP, Gen. Counsel & Secretary | 06/30/2017 | 21,171 |
| Korenberg Matthew E | VP, Finance and CFO | 06/30/2017 | 21,171 |
| HIGGINS JOHN L | Chief Executive Officer | 06/21/2017 | 97,986 |
| HIGGINS JOHN L | Chief Executive Officer | 06/21/2017 | 559,920 |
| HIGGINS JOHN L | Chief Executive Officer | 06/09/2017 | 252,000 |
| HIGGINS JOHN L | Chief Executive Officer | 06/09/2017 | 1,378,440 |
| FOEHR MATTHEW W | President and COO | 05/15/2017 | 21,934 |
| FOEHR MATTHEW W | President and COO | 05/12/2017 | 56,041 |
| FOEHR MATTHEW W | President and COO | 05/12/2017 | 630,648 |
| Aryeh Jason | Director | 05/12/2017 | 1,631,332 |
| Aryeh Jason | Director | 05/11/2017 | 2,494,034 |
| HIGGINS JOHN L | Chief Executive Officer | 03/20/2017 | 436,400 |
| HIGGINS JOHN L | Chief Executive Officer | 03/08/2017 | 157,493 |
| HIGGINS JOHN L | Chief Executive Officer | 03/08/2017 | 157,534 |
| HIGGINS JOHN L | Chief Executive Officer | 03/08/2017 | 428,240 |
| FOEHR MATTHEW W | President and COO | 03/03/2017 | 19,940 |
| FOEHR MATTHEW W | President and COO | 03/02/2017 | 68,584 |
| FOEHR MATTHEW W | President and COO | 03/02/2017 | 711,213 |
| Aryeh Jason | Director | 02/28/2017 | 753,060 |
| Aryeh Jason | Director | 02/27/2017 | 2,650,000 |
| Korenberg Matthew E | VP, Finance and CFO | 02/24/2017 | 105,499 |
| Korenberg Matthew E | VP, Finance and CFO | 02/15/2017 | 40,773 |
| Korenberg Matthew E | VP, Finance and CFO | 08/06/2016 | 75,090 |
| FOEHR MATTHEW W | President and COO | 02/24/2017 | 274,339 |
| FOEHR MATTHEW W | President and COO | 02/15/2017 | 246,831 |
| HIGGINS JOHN L | Chief Executive Officer | 02/24/2017 | 480,118 |
| HIGGINS JOHN L | Chief Executive Officer | 02/15/2017 | 448,821 |
| Korenberg Matthew E | VP, Finance and CFO | 12/30/2016 | 3,455 |
| Aryeh Jason | Director | 11/25/2016 | 372,007 |
| Aryeh Jason | Director | 11/22/2016 | 1,611,062 |
| Aryeh Jason | Director | 11/16/2016 | 141,419 |
| Aryeh Jason | Director | 11/18/2016 | 525,000 |
| Davis Todd C | Director | 10/31/2016 | 638,362 |
| HIGGINS JOHN L | Chief Executive Officer | 09/22/2016 | 352,020 |
| KOZARICH JOHN W | Director | 09/07/2016 | 115,000 |
| KOZARICH JOHN W | Director | 09/01/2016 | 75,970 |
| KOZARICH JOHN W | Director | 09/01/2016 | 175,597 |
| FOEHR MATTHEW W | President and COO | 08/08/2016 | 41,126 |
| FOEHR MATTHEW W | President and COO | 08/05/2016 | 124,625 |
| FOEHR MATTHEW W | President and COO | 08/05/2016 | 1,526,750 |
| Berkman Charles S | VP, Gen. Counsel & Secretary | 08/05/2016 | 1,661,857 |
| Berkman Charles S | VP, Gen. Counsel & Secretary | 08/05/2016 | 2,717,772 |
| KOZARICH JOHN W | Director | 08/01/2016 | 137,569 |
| Korenberg Matthew E | VP, Finance and CFO | 06/30/2016 | 17,072 |
| Herman Melanie J | Director of Accounting | 06/30/2016 | 13,675 |
| KOZARICH JOHN W | Director | 07/01/2016 | 121,402 |
| KOZARICH JOHN W | Director | 06/01/2016 | 117,419 |
| Herman Melanie J | Director of Accounting | 05/18/2016 | 40,247 |
| Aryeh Jason | Director | 05/06/2016 | 1,777,830 |
| Aryeh Jason | Director | 05/05/2016 | 1,202,120 |
| KOZARICH JOHN W | Director | 05/02/2016 | 121,568 |
| KOZARICH JOHN W | Director | 04/06/2016 | 575,000 |
| FOEHR MATTHEW W | President and COO | 03/17/2016 | 86,241 |
| FOEHR MATTHEW W | President and COO | 03/17/2016 | 618,880 |
| Aryeh Jason | Director | 03/08/2016 | 51,245 |
| Aryeh Jason | Director | 03/07/2016 | 568,895 |
| HIGGINS JOHN L | Chief Executive Officer | 03/08/2016 | 126,000 |
| HIGGINS JOHN L | Chief Executive Officer | 03/07/2016 | 1,110,027 |
| HIGGINS JOHN L | Chief Executive Officer | 02/15/2016 | 214,237 |
| FOEHR MATTHEW W | President and COO | 02/15/2016 | 141,163 |
| Herman Melanie J | Director of Accounting | 02/15/2016 | 13,755 |
| KOZARICH JOHN W | Director | 01/20/2016 | 98,960 |
| KOZARICH JOHN W | Director | 01/20/2016 | 158,173 |
| Herman Melanie J | Director of Accounting | 12/31/2015 | 11,554 |
| Aryeh Jason | Director | 11/11/2015 | 304,470 |
| Herman Melanie J | Director of Accounting | 11/11/2015 | 365,034 |
| Herman Melanie J | Director of Accounting | 11/11/2015 | 779,619 |
| KNOTT DAVID M | Director | 08/17/2015 | 383,937 |
| KNOTT DAVID M | Director | 08/12/2015 | 952,486 |
| KNOTT DAVID M | Director | 08/12/2015 | 77,163 |
| KNOTT DAVID M | Director | 08/13/2015 | 695,014 |
| KNOTT DAVID M | Director | 08/13/2015 | 2,626,143 |
| KNOTT DAVID M | Director | 08/13/2015 | 192,391 |
| KNOTT DAVID M | Director | 08/12/2015 | 250,781 |
| KNOTT DAVID M | Director | 08/07/2015 | 19,803 |
| HIGGINS JOHN L | Chief Executive Officer | 08/06/2015 | 516,946 |
| Davis Todd C | Director | 08/06/2015 | 232,288 |
| Berkman Charles S | VP, Gen. Counsel & Secretary | 07/13/2015 | 53,100 |
| Berkman Charles S | VP, Gen. Counsel & Secretary | 07/10/2015 | 178,687 |
| Berkman Charles S | VP, Gen. Counsel & Secretary | 07/10/2015 | 1,394,610 |
| Berkman Charles S | VP, Gen. Counsel & Secretary | 06/30/2015 | 21,237 |
| Herman Melanie J | Interim CFO | 06/30/2015 | 7,536 |
| FOEHR MATTHEW W | President and COO | 06/29/2015 | 24,925 |
| FOEHR MATTHEW W | President and COO | 06/26/2015 | 124,625 |
| FOEHR MATTHEW W | President and COO | 06/26/2015 | 1,262,125 |
| FOEHR MATTHEW W | President and COO | 06/22/2015 | 249,709 |
| FOEHR MATTHEW W | President and COO | 06/22/2015 | 2,222,815 |
| Herman Melanie J | Interim CFO | 06/10/2015 | 156,885 |
| Herman Melanie J | Interim CFO | 06/10/2015 | 385,688 |
| HIGGINS JOHN L | Chief Executive Officer | 06/09/2015 | 928,809 |
| Aryeh Jason | Director | 06/04/2015 | 151,995 |
| Aryeh Jason | Director | 05/20/2015 | 87,650 |
| Aryeh Jason | Director | 05/19/2015 | 198,957 |
| Aryeh Jason | Director | 05/18/2015 | 520,440 |
| DeSilva Nishan M | VP, Finance & Strategy and CFO | 05/13/2015 | 436,408 |
| DeSilva Nishan M | VP, Finance & Strategy and CFO | 05/12/2015 | 409,664 |
| DeSilva Nishan M | VP, Finance & Strategy and CFO | 05/14/2015 | 1,558,206 |
| DeSilva Nishan M | VP, Finance & Strategy and CFO | 05/13/2015 | 1,990,671 |
| DeSilva Nishan M | VP, Finance & Strategy and CFO | 05/12/2015 | 1,990,403 |
| DeSilva Nishan M | VP, Finance & Strategy and CFO | 05/14/2015 | 1,755,442 |
| Patel Sunil | Director | 03/19/2015 | 341,662 |
| Berkman Charles S | VP, Gen. Counsel & Secretary | 03/16/2015 | 106,939 |
| Berkman Charles S | VP, Gen. Counsel & Secretary | 03/16/2015 | 839,649 |
| Berkman Charles S | VP, Gen. Counsel & Secretary | 12/31/2014 | 5,699 |
| Herman Melanie J | Director of Accounting | 03/02/2015 | 32,469 |
| Herman Melanie J | Director of Accounting | 12/31/2014 | 4,659 |
| Herman Melanie J | Director of Accounting | 02/19/2015 | 29,498 |
| DeSilva Nishan M | VP, Corporate Development | 02/10/2015 | 129,582 |
| Berkman Charles S | VP, Gen. Counsel & Secretary | 12/31/2014 | 5,699 |
| FOEHR MATTHEW W | EVP and COO | 12/31/2014 | 2,081 |
| Herman Melanie J | Director of Accounting | 12/31/2014 | 4,659 |
| KOZARICH JOHN W | Director | 10/15/2014 | 91,360 |
| FOEHR MATTHEW W | EVP and COO | 10/13/2014 | 9,970 |
| FOEHR MATTHEW W | EVP and COO | 10/10/2014 | 3,817 |
| Sabba Stephen L | Director | 10/09/2014 | 86,230 |
| KNOTT DAVID M | Director | 10/09/2014 | 172,029 |
| Sabba Stephen L | Director | 10/09/2014 | 86,230 |
| KNOTT DAVID M | Director | 10/09/2014 | 172,029 |
| Aryeh Jason | Director | 10/09/2014 | 472,890 |
| KOZARICH JOHN W | Director | 10/07/2014 | 21,450 |
| Aryeh Jason | Director | 10/01/2014 | 236,920 |
| Aryeh Jason | Director | 09/25/2014 | 236,584 |
| HIGGINS JOHN L | President & CEO | 08/15/2014 | 54,970 |
| Herman Melanie J | Director of Accounting | 06/30/2014 | 4,292 |
| Berkman Charles S | VP, Gen. Counsel & Secretary | 06/30/2014 | 14,408 |
| FOEHR MATTHEW W | EVP and COO | 06/30/2014 | 18,743 |
| Herman Melanie J | Director of Accounting | 06/09/2014 | 13,741 |
| Herman Melanie J | Director of Accounting | 06/09/2014 | 76,648 |
| Berkman Charles S | VP, Gen. Counsel & Secretary | 05/27/2014 | 47,007 |
| Berkman Charles S | VP, Gen. Counsel & Secretary | 05/27/2014 | 479,434 |
| BVF PARTNERS L P/IL | See Explanation of Responses | 03/24/2014 | 2,224,163 |
| BVF PARTNERS L P/IL | See Explanation of Responses | 03/25/2014 | 713,734 |
| BVF PARTNERS L P/IL | See Explanation of Responses | 03/25/2014 | 1,260,489 |
| BVF PARTNERS L P/IL | See Explanation of Responses | 03/24/2014 | 1,284,483 |
| Davis Todd C | Director | 03/19/2014 | 398,147 |
| Davis Todd C | Director | 03/18/2014 | 198,637 |
| LAMATTINA JOHN L | Director | 03/18/2014 | 44,850 |
| LAMATTINA JOHN L | Director | 03/18/2014 | 394,150 |
| Sabba Stephen L | Director | 02/27/2014 | 36,125 |
| KNOTT DAVID M | Director | 02/20/2014 | 65,676 |
| BVF PARTNERS L P/IL | 10% Owner | 02/18/2014 | 1,045,409 |
| BVF PARTNERS L P/IL | 10% Owner | 02/20/2014 | 771,167 |
| BVF PARTNERS L P/IL | 10% Owner | 02/18/2014 | 11,478,450 |
| BVF PARTNERS L P/IL | 10% Owner | 02/20/2014 | 1,359,787 |
| BVF PARTNERS L P/IL | 10% Owner | 02/18/2014 | 1,219,209 |
| BVF PARTNERS L P/IL | 10% Owner | 02/19/2014 | 202,375 |
| BVF PARTNERS L P/IL | 10% Owner | 02/18/2014 | 1,262,808 |
| BVF PARTNERS L P/IL | 10% Owner | 02/19/2014 | 4,189,921 |
| BVF PARTNERS L P/IL | 10% Owner | 02/19/2014 | 394,015 |
| BVF PARTNERS L P/IL | 10% Owner | 02/20/2014 | 391,464 |
| BVF PARTNERS L P/IL | 10% Owner | 02/19/2014 | 691,187 |
| BVF PARTNERS L P/IL | 10% Owner | 02/20/2014 | 8,208,319 |
| KNOTT DAVID M | Director | 02/14/2014 | 1,524,229 |
| KNOTT DAVID M | Director | 02/18/2014 | 285,919 |
| KNOTT DAVID M | Director | 02/18/2014 | 845,368 |
| KNOTT DAVID M | Director | 02/14/2014 | 516,583 |
| Aryeh Jason | Director | 02/14/2014 | 749,265 |
| Aryeh Jason | Director | 02/13/2014 | 518,779 |
| Aryeh Jason | Director | 02/12/2014 | 1,814,121 |
| Sharp John P | VP Finance and CFO | 02/12/2014 | 1,528,059 |
| Sharp John P | VP Finance and CFO | 02/12/2014 | 6,498,898 |
| Berkman Charles S | VP, Gen. Counsel & Secretary | 02/12/2014 | 240,784 |
| Berkman Charles S | VP, Gen. Counsel & Secretary | 02/13/2014 | 28,940 |
| Berkman Charles S | VP, Gen. Counsel & Secretary | 02/12/2014 | 1,108,635 |
| HIGGINS JOHN L | President & CEO | 02/12/2014 | 168,075 |
| HIGGINS JOHN L | President & CEO | 02/12/2014 | 1,265,625 |
| FOEHR MATTHEW W | EVP and COO | 02/14/2014 | 258,662 |
| FOEHR MATTHEW W | EVP and COO | 02/14/2014 | 1,789,650 |
| HIGGINS JOHN L | President & CEO | 01/21/2014 | 189,000 |
| HIGGINS JOHN L | President & CEO | 01/16/2014 | 960,000 |
| FOEHR MATTHEW W | EVP and COO | 12/31/2013 | 2,849 |
| Berkman Charles S | VP, Gen. Counsel & Secretary | 12/31/2013 | 7,088 |
| Sharp John P | VP Finance and CFO | 12/12/2013 | 6,972 |
| Sharp John P | VP Finance and CFO | 12/12/2013 | 37,408 |
| FOEHR MATTHEW W | EVP and COO | 12/12/2013 | 59,820 |
| FOEHR MATTHEW W | EVP and COO | 12/12/2013 | 320,400 |
| Sharp John P | VP Finance and CFO | 12/06/2013 | 336,480 |
| BVF PARTNERS L P/IL | 10% Owner | 11/27/2013 | 18,207,114 |
| BVF PARTNERS L P/IL | 10% Owner | 11/26/2013 | 12,003,345 |
| KOZARICH JOHN W | Director | 11/25/2013 | 8,833 |
| KOZARICH JOHN W | Director | 11/18/2013 | 6,836 |
| Sharp John P | VP Finance and CFO | 11/18/2013 | 6,215 |
| Sharp John P | VP Finance and CFO | 11/18/2013 | 59,519 |
| HIGGINS JOHN L | President & CEO | 10/22/2013 | 169,763 |
| HIGGINS JOHN L | President & CEO | 10/18/2013 | 550,000 |
| BVF PARTNERS L P/IL | 10% Owner | 09/23/2013 | 15,976,524 |
| KNOTT DAVID M | Director | 09/12/2013 | 7,484,080 |
| Berkman Charles S | VP, Gen. Counsel & Secretary | 08/30/2013 | 653,697 |
| Berkman Charles S | VP, Gen. Counsel & Secretary | 08/30/2013 | 1,346,456 |
| Sharp John P | VP Finance and CFO | 08/16/2013 | 74,700 |
| Sharp John P | VP Finance and CFO | 08/16/2013 | 320,619 |
| Berkman Charles S | VP, Gen. Counsel & Secretary | 08/19/2013 | 43,054 |
| Berkman Charles S | VP, Gen. Counsel & Secretary | 08/16/2013 | 145,247 |
| Berkman Charles S | VP, Gen. Counsel & Secretary | 08/16/2013 | 621,732 |
| HIGGINS JOHN L | President & CEO | 08/19/2013 | 105,814 |
| HIGGINS JOHN L | President & CEO | 08/16/2013 | 428,500 |
| DeSilva Nishan M | VP, Corporate Development | 06/28/2013 | 2,934 |
| FOEHR MATTHEW W | EVP and COO | 06/28/2013 | 18,384 |
| Berkman Charles S | VP, Gen. Counsel & Secretary | 06/28/2013 | 14,148 |
| Berkman Charles S | VP, Gen. Counsel & Secretary | 05/10/2013 | 106,640 |
| BVF PARTNERS L P/IL | 10% Owner | 01/23/2013 | 783,181 |
| DeSilva Nishan M | VP, Corporate Development | 12/31/2012 | 7,122 |
| KOZARICH JOHN W | Director | 12/21/2012 | 40,196 |
| BVF PARTNERS L P/IL | 10% Owner | 12/14/2012 | 100,365 |
| BVF PARTNERS L P/IL | 10% Owner | 12/06/2012 | 898,959 |
| FOEHR MATTHEW W | EVP and COO | 12/05/2012 | 6,656 |
| HIGGINS JOHN L | President & CEO | 12/05/2012 | 36,060 |
| KNOTT DAVID M | Director | 11/30/2012 | 131,111 |
| KNOTT DAVID M | Director | 11/29/2012 | 266,960 |
| KNOTT DAVID M | Director | 11/27/2012 | 1,270,750 |
| KNOTT DAVID M | Director | 11/28/2012 | 682,850 |
| BVF PARTNERS L P/IL | 10% Owner | 10/31/2012 | 61,096 |
| BVF PARTNERS L P/IL | 10% Owner | 10/26/2012 | 190,926 |
| KNOTT DAVID M | Director | 08/29/2012 | 44,875 |
| BVF PARTNERS L P/IL | 10% Owner | 10/31/2012 | 61,096 |
| BVF PARTNERS L P/IL | 10% Owner | 10/26/2012 | 190,926 |
| Berkman Charles S | VP, Gen. Counsel & Secretary | 09/07/2012 | 79,754 |
| HIGGINS JOHN L | President & CEO | 08/13/2012 | 8,195 |
| HIGGINS JOHN L | President & CEO | 06/29/2012 | 12,654 |
| FOEHR MATTHEW W | EVP and COO | 06/29/2012 | 12,654 |
| Berkman Charles S | VP, Gen. Counsel & Secretary | 06/29/2012 | 12,654 |
| Aryeh Jason | Director | 06/01/2012 | 8,386 |
| Sabba Stephen L | Director | 06/01/2012 | 24,040 |
| KNOTT DAVID M | Director | 05/24/2012 | 277,718 |
| KNOTT DAVID M | Director | 05/24/2012 | 1,999,802 |
| KNOTT DAVID M | Director | 05/24/2012 | 885,061 |
| KNOTT DAVID M | Director | 05/24/2012 | 1,146,115 |
| KNOTT DAVID M | Director | 05/24/2012 | 246,344 |
| Patel Sunil | Director | 05/23/2012 | 17,070 |
| HIGGINS JOHN L | President & CEO | 05/04/2012 | 12,040 |
| Berkman Charles S | VP, Gen. Counsel & Secretary | 03/08/2012 | 56,832 |
| HIGGINS JOHN L | President & CEO | 12/30/2011 | 2,119 |
| FOEHR MATTHEW W | EVP and COO | 12/30/2011 | 12,612 |
| Berkman Charles S | VP, Gen. Counsel & Secretary | 12/30/2011 | 12,491 |
| BVF PARTNERS L P/IL | 10% Owner | 11/21/2011 | 3,602,718 |
| BVF PARTNERS L P/IL | 10% Owner | 11/21/2011 | 1,039,631 |
| BVF PARTNERS L P/IL | 10% Owner | 11/18/2011 | 799,795 |
| KOZARICH JOHN W | Director | 11/11/2011 | 11,787 |
| Sabba Stephen L | Director | 11/14/2011 | 11,500 |
| Sabba Stephen L | Director | 11/10/2011 | 11,690 |
| KNOTT DAVID M | Director | 11/10/2011 | 46,320 |
| Aryeh Jason | Director | 11/10/2011 | 10,900 |
| Aryeh Jason | Director | 11/10/2011 | 11,010 |
| Patel Sunil | Director | 11/10/2011 | 27,774 |
| BVF PARTNERS L P/IL | 10% Owner | 10/26/2011 | 83,751 |
| BVF PARTNERS L P/IL | 10% Owner | 10/21/2011 | 64,062 |
| BVF PARTNERS L P/IL | 10% Owner | 10/18/2011 | 30,215 |
| BVF PARTNERS L P/IL | 10% Owner | 10/20/2011 | 165,809 |
| BVF PARTNERS L P/IL | 10% Owner | 10/13/2011 | 233,880 |
| BVF PARTNERS L P/IL | 10% Owner | 10/13/2011 | 67,692 |
| BVF PARTNERS L P/IL | 10% Owner | 10/12/2011 | 726,992 |
| BVF PARTNERS L P/IL | 10% Owner | 10/04/2011 | 183,961 |
| KNOTT DAVID M | Director | 09/01/2011 | 22,815 |
| KNOTT DAVID M | Director | 09/01/2011 | 80,917 |
| KNOTT DAVID M | Director | 09/01/2011 | 37,721 |
| KNOTT DAVID M | Director | 09/01/2011 | 10,647 |
| KNOTT DAVID M | Director | 08/30/2011 | 24,321 |
| KNOTT DAVID M | Director | 08/30/2011 | 10,381 |
| KNOTT DAVID M | Director | 08/30/2011 | 20,762 |
| KNOTT DAVID M | Director | 08/31/2011 | 8,964 |
| KNOTT DAVID M | Director | 08/30/2011 | 77,116 |
| KNOTT DAVID M | Director | 08/31/2011 | 2,988 |
| KNOTT DAVID M | Director | 08/31/2011 | 7,470 |
| KNOTT DAVID M | Director | 08/31/2011 | 25,398 |
| KNOTT DAVID M | Director | 08/29/2011 | 147,784 |
| KNOTT DAVID M | Director | 08/26/2011 | 139,934 |
| KNOTT DAVID M | Director | 08/26/2011 | 32,604 |
| KNOTT DAVID M | Director | 08/26/2011 | 82,764 |
| KNOTT DAVID M | Director | 08/29/2011 | 75,313 |
| KNOTT DAVID M | Director | 08/26/2011 | 265,848 |
| KNOTT DAVID M | Director | 08/29/2011 | 17,052 |
| KNOTT DAVID M | Director | 08/29/2011 | 44,051 |
| KNOTT DAVID M | Director | 08/25/2011 | 124,443 |
| KNOTT DAVID M | Director | 08/25/2011 | 31,425 |
| KNOTT DAVID M | Director | 08/25/2011 | 72,906 |
| KNOTT DAVID M | Director | 08/25/2011 | 246,372 |
| KNOTT DAVID M | Director | 08/25/2011 | 216,204 |
| KNOTT DAVID M | Director | 08/24/2011 | 51,800 |
| KNOTT DAVID M | Director | 08/23/2011 | 125,454 |
| KNOTT DAVID M | Director | 08/24/2011 | 11,655 |
| KNOTT DAVID M | Director | 08/24/2011 | 30,950 |
| KNOTT DAVID M | Director | 08/24/2011 | 97,125 |
| KNOTT DAVID M | Director | 08/23/2011 | 65,772 |
| KNOTT DAVID M | Director | 08/24/2011 | 33,670 |
| KNOTT DAVID M | Director | 08/23/2011 | 14,616 |
| KNOTT DAVID M | Director | 08/24/2011 | 53,095 |
| KNOTT DAVID M | Director | 08/23/2011 | 37,758 |
| KNOTT DAVID M | Director | 08/19/2011 | 51,428 |
| KNOTT DAVID M | Director | 08/19/2011 | 171,028 |
| KNOTT DAVID M | Director | 08/22/2011 | 12,828 |
| KNOTT DAVID M | Director | 08/22/2011 | 2,400 |
| KNOTT DAVID M | Director | 08/22/2011 | 6,000 |
| KNOTT DAVID M | Director | 08/22/2011 | 20,400 |
| KNOTT DAVID M | Director | 08/19/2011 | 88,504 |
| KNOTT DAVID M | Director | 08/19/2011 | 21,528 |
| BVF PARTNERS L P/IL | 10% Owner | 08/19/2011 | 254,020 |
| BVF PARTNERS L P/IL | 10% Owner | 08/18/2011 | 197,371 |
| KNOTT DAVID M | Director | 08/18/2011 | 29,775 |
| KNOTT DAVID M | Director | 08/18/2011 | 100,044 |
| KNOTT DAVID M | Director | 08/17/2011 | 26,343 |
| KNOTT DAVID M | Director | 08/17/2011 | 7,410 |
| KNOTT DAVID M | Director | 08/17/2011 | 14,820 |
| KNOTT DAVID M | Director | 08/18/2011 | 48,831 |
| KNOTT DAVID M | Director | 08/17/2011 | 51,870 |
| KNOTT DAVID M | Director | 08/18/2011 | 11,910 |
| BVF PARTNERS L P/IL | 10% Owner | 08/11/2011 | 15,601 |
| KNOTT DAVID M | Director | 08/15/2011 | 8,379 |
| KNOTT DAVID M | Director | 08/15/2011 | 28,728 |
| KNOTT DAVID M | Director | 08/12/2011 | 41,342 |
| KNOTT DAVID M | Director | 08/12/2011 | 9,592 |
| KNOTT DAVID M | Director | 08/12/2011 | 26,378 |
| KNOTT DAVID M | Director | 08/15/2011 | 14,364 |
| KNOTT DAVID M | Director | 08/12/2011 | 87,527 |
| KNOTT DAVID M | Director | 08/15/2011 | 3,591 |
| KNOTT DAVID M | Director | 08/10/2011 | 79,920 |
| KNOTT DAVID M | Director | 08/11/2011 | 21,755 |
| KNOTT DAVID M | Director | 08/10/2011 | 264,600 |
| KNOTT DAVID M | Director | 08/11/2011 | 17,175 |
| KNOTT DAVID M | Director | 08/10/2011 | 870,480 |
| KNOTT DAVID M | Director | 08/11/2011 | 44,655 |
| KNOTT DAVID M | Director | 08/11/2011 | 145,415 |
| KNOTT DAVID M | Director | 08/10/2011 | 60,480 |
| KNOTT DAVID M | Director | 08/10/2011 | 74,520 |
| Davis Todd C | Director | 08/10/2011 | 163,500 |
| Patel Sunil | Director | 08/10/2011 | 53,705 |
| Aryeh Jason | Director | 08/10/2011 | 21,140 |
| BVF PARTNERS L P/IL | 10% Owner | 08/09/2011 | 1,444,912 |
| BVF PARTNERS L P/IL | 10% Owner | 08/09/2011 | 629,026 |
| BVF PARTNERS L P/IL | 10% Owner | 08/08/2011 | 1,969,663 |
| BVF PARTNERS L P/IL | 10% Owner | 08/10/2011 | 2,542,659 |
| HIGGINS JOHN L | President & CEO | 06/30/2011 | 2,116 |
| HIGGINS JOHN L | President & CEO | 12/31/2010 | 2,099 |
| Aryeh Jason | Director | 05/12/2011 | 18,906 |
| Aryeh Jason | Director | 03/11/2011 | 9,830 |
| Aryeh Jason | Director | 03/11/2011 | 29,525 |
| Aryeh Jason | Director | 03/16/2011 | 37,405 |
| Aryeh Jason | Director | 03/15/2011 | 14,235 |
| Aryeh Jason | Director | 03/14/2011 | 33,900 |
| LAMATTINA JOHN L | Director | 03/11/2011 | 98,030 |
| Aryeh Jason | Director | 03/10/2011 | 10,045 |
| Aryeh Jason | Director | 03/10/2011 | 5,080 |
| KNOTT DAVID M | Director | 03/03/2011 | 147,668 |
| KNOTT DAVID M | Director | 03/03/2011 | 253,460 |
| KNOTT DAVID M | Director | 03/03/2011 | 11,020 |
| KOZARICH JOHN W | Director | 02/25/2011 | 17,872 |
| KOZARICH JOHN W | Director | 02/24/2011 | 32,056 |
| Kazmi Syed | VP, Bus. Dev. & Strategic Plan | 02/28/2011 | 12,459 |
| KOZARICH JOHN W | Director | 02/25/2011 | 17,872 |
| KOZARICH JOHN W | Director | 02/24/2011 | 32,056 |
| KNOTT DAVID M | Director | 02/25/2011 | 144,609 |
| KNOTT DAVID M | Director | 02/24/2011 | 162,997 |
| KNOTT DAVID M | Director | 02/28/2011 | 100,292 |
| KNOTT DAVID M | Director | 02/23/2011 | 212,930 |
| KNOTT DAVID M | Director | 02/23/2011 | 21,890 |
| KNOTT DAVID M | Director | 02/23/2011 | 648,740 |
| KNOTT DAVID M | Director | 02/23/2011 | 66,933 |
| KNOTT DAVID M | Director | 02/23/2011 | 468,516 |
| KNOTT DAVID M | Director | 02/23/2011 | 311,743 |
| KNOTT DAVID M | Director | 02/23/2011 | 103,301 |
| Aryeh Jason | Director | 02/23/2011 | 49,700 |
| Berkman Charles S | VP, Gen. Counsel & Secretary | 02/16/2011 | 48,751 |
| KOZARICH JOHN W | Director | 02/17/2011 | 9,900 |
| Patel Sunil | Director | 02/16/2011 | 92,174 |
| KOZARICH JOHN W | Director | 11/11/2010 | 15,954 |
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FUNDS WITH A POSITION IN LIGAND PHARMACEUTICALS, INC.
| Fund | # Shares Owned | % of Portfolio | % Change | Investing Style |
|---|---|---|---|---|
| BLACKROCK INC. | 2,789,764 | 0.00584% | 4.66% | Other |
| GEODE CAPITAL MANAGEMENT, LLC | 300,670 | 0.00282% | 3.64% | Other |
| D. E. SHAW & CO., INC. | 51,301 | 0.00379% | New | Other |
| FISHER ASSET MANAGEMENT, LLC | 39,658 | 0.00179% | 40.18% | Other |
| AQR CAPITAL MANAGEMENT LLC | 31,108 | 0.00468% | 8.62% | Other |
| RENAISSANCE TECHNOLOGIES LLC | 24,500 | 0.00224% | 46.71% | Other |
| CANDRIAM S.C.A. | 13,546 | 0.0061% | New | Other |
| TUDOR INVESTMENT CORP ET AL | 9,944 | 0.01% | New | Event Driven, Other |
| ALPS ADVISORS INC | 9,239 | 0.00753% | Exited | Other |
| GOTHAM ASSET MANAGEMENT, LLC | 4,543 | 0.01% | Exited | Other |
CHANGE IN SHARES OUTSTANDING FOR LIGAND PHARMACEUTICALS, INC.
STOCK BUYBACKS FOR LIGAND PHARMACEUTICALS, INC.
Period of Report
Previous Period
% Change in Shares
10-K/10-Q Filings
Quarter
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Period of Report: 03/31/2022
10-K/10-Q Filings: View
Previous Period
% Change in Shares
Quarter
12/31/2021
-0.17%
1Q
09/30/2021
0.67%
2Q
06/30/2021
0.88%
3Q
03/31/2021
1.03%
4Q
12/31/2020
1.27%
5Q
09/30/2020
4.55%
6Q
06/30/2020
4.64%
7Q
03/31/2020
4.82%
8Q
12/31/2019
1.93%
9Q
09/30/2019
-4.21%
10Q
06/30/2019
-11.51%
11Q
03/31/2019
-14.16%
12Q
12/31/2018
-17.71%
13Q
09/30/2018
-20.84%
14Q
06/30/2018
-20.28%
15Q
03/31/2018
-21.02%
16Q
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BUYBACK ANNOUNCEMENT(S) FOR LIGAND PHARMACEUTICALS, INC.
Price on Announcement
$91.80
Buyback/Market Cap (%)
28.65%
Buyback Amount
$500M
Buyback Shares
5,446,623
Buyback Type
New
Repurchase Method
Market Price
Date Announced
09/11/2019 (Announcement)
Market Cap at Announcement
$1.75B
Price on Announcement
$91.80
Buyback/Market Cap (%)
28.65%
Buyback Amount
$500M
Buyback Shares
5,446,623
Buyback Type
New
Repurchase Method
Market Price
Price on Announcement
$111.78
Buyback/Market Cap (%)
6.31%
Buyback Amount
$150M
Buyback Shares
1,341,922
Buyback Type
Additional
Repurchase Method
Market Price
Date Announced
01/23/2019 (Announcement)
Market Cap at Announcement
$2.38B
Price on Announcement
$111.78
Buyback/Market Cap (%)
6.31%
Buyback Amount
$150M
Buyback Shares
1,341,922
Buyback Type
Additional
Repurchase Method
Market Price
Price on Announcement
$257.78
Buyback/Market Cap (%)
3.68%
Buyback Amount
$200M
Buyback Shares
775,855
Buyback Type
New
Repurchase Method
Market Price
Date Announced
09/20/2018 (Announcement)
Market Cap at Announcement
$5.44B
Price on Announcement
$257.78
Buyback/Market Cap (%)
3.68%
Buyback Amount
$200M
Buyback Shares
775,855
Buyback Type
New
Repurchase Method
Market Price