Inspire Medical Systems, Inc. (INSP) NYSE
$203.69 0.01 (0.00%)
Market Cap: $6.07B
As of 09/13/24 11:24 AM EDT. Market open.
Inspire Medical Systems, Inc. (INSP)
NYSE
$203.69
0.01 (0.00%)
Market Cap: $6.07B
As of 09/13/24 11:24 AM EDT. Market open.
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Inspire Medical Systems, Inc., a medical technology company, focuses on the development and commercialization of minimally invasive solutions for patients with obstructive sleep apnea (OSA) in the United States and internationally. The company offers Inspire system, a neurostimulation technology that provides a safe and effective treatment for moderate to severe OSA. It also develops a novel, a ... read more
COMPANY PROFILE
Sector
Healthcare
Industry
Medical - Devices
CEO
Mr. Timothy P. Herbert
Full Time Employees
1,011
CEO Compensation (Base)
$690,000
CEO Compensation (Total)
$7.49M
Sector
Healthcare
Industry
Medical - Devices
CEO
Mr. Timothy P. Herbert
Full Time Employees
1,011
CEO Compensation (Base)
$690,000
CEO Compensation (Total)
$7.49M
Address
5500 Wayzata Boulevard, MN, Golden Valley, 55416.
PRICE CHART FOR INSPIRE MEDICAL SYSTEMS, INC.
From:
To:
NEWS
INSIDEARBITRAGE ARTICLES
KEY STATS
Open
$202.97
Previous Close
$203.68
Days Range
$202.97 - $207.35
52 week range
$123 - $257.40
Volume
122,328
Avg. Volume (30 days)
636,777
Market Cap
$6.07B
Dividend Yield
-
P/E
969.93
Shares Outstanding
29,821,700
Open
$202.97
Previous Close
$203.68
Days Range
$202.97 - $207.35
52 week range
$123 - $257.40
Volume
122,328
Avg. Volume (30 days)
636,777
Market Cap
$6.07B
Dividend Yield
-
P/E
969.93
Shares Outstanding
29,821,700
FINANCIAL STATEMENTS FOR INSPIRE MEDICAL SYSTEMS, INC.
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INSIDER TRANSACTIONS FOR INSPIRE MEDICAL SYSTEMS, INC.
| Owner | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| McCormick Shawn | Director | Sep 09, 2024 | Sale | $220.00 | 800 | 176,000 | 23,140 | Sep 11, 2024, 05:02 PM |
| Rondoni John | Chief Technology Officer | Sep 09, 2024 | Sale | $215.00 | 31 | 6,665 | 11,348 | Sep 11, 2024, 05:01 PM |
| Rondoni John | Chief Technology Officer | Aug 22, 2024 | Option Exercise | $71.00 | 5,000 | 355,000 | 16,379 | Aug 23, 2024, 04:09 PM |
| Rondoni John | Chief Technology Officer | Aug 22, 2024 | Sale | $189.83 | 5,000 | 949,143 | 15,178 | Aug 23, 2024, 04:09 PM |
| Ban Randy | Chief Commercial Officer | Aug 16, 2024 | Option Exercise | $42.15 | 4,861 | 204,891 | 7,917 | Aug 19, 2024, 08:14 PM |
| Ban Randy | Chief Commercial Officer | Aug 15, 2024 | Option Exercise | $42.15 | 16,139 | 680,259 | 19,195 | Aug 19, 2024, 08:14 PM |
| Ban Randy | Chief Commercial Officer | Aug 15, 2024 | Sale | $193.10 | 16,139 | 3,116,397 | 18,419 | Aug 19, 2024, 08:14 PM |
| Ban Randy | Chief Commercial Officer | Aug 16, 2024 | Sale | $188.55 | 4,861 | 916,549 | 7,017 | Aug 19, 2024, 08:14 PM |
| McCormick Shawn | Director | Aug 14, 2024 | Option Exercise | $0.94 | 8,537 | 8,025 | 23,940 | Aug 15, 2024, 04:19 PM |
| Tansey Casey M | Director | Jul 15, 2024 | Option Exercise | $138.58 | 103 | 14,274 | 20,363 | Jul 17, 2024, 05:09 PM |
| Melenikiotou Georgia | Director | Jul 15, 2024 | Option Exercise | $138.58 | 32 | 4,435 | 2,134 | Jul 17, 2024, 05:08 PM |
| Ellis Gary Lee | Director | Jul 15, 2024 | Option Exercise | $138.58 | 154 | 21,341 | 4,174 | Jul 17, 2024, 05:07 PM |
| Broader Shelley G. | Director | Jul 15, 2024 | Option Exercise | $138.58 | 117 | 16,214 | 2,423 | Jul 17, 2024, 05:06 PM |
| McCormick Shawn | Director | May 10, 2024 | Option Exercise | $0.94 | 2,500 | 2,350 | 15,403 | May 13, 2024, 04:30 PM |
| NELSON MARILYN C | Director | Apr 29, 2024 | Option Exercise | $240.68 | 1,175 | 282,799 | 35,620 | May 01, 2024, 04:01 PM |
| Buchholz Richard | Chief Financial Officer | Apr 17, 2024 | Sale | $230.03 | 15,000 | 3,450,450 | 28,271 | Apr 18, 2024, 04:44 PM |
| Ellis Gary Lee | Director | Apr 12, 2024 | Option Exercise | $231.74 | 70 | 16,222 | 3,304 | Apr 16, 2024, 05:18 PM |
| Tansey Casey M | Director | Apr 12, 2024 | Option Exercise | $231.74 | 62 | 14,368 | 19,544 | Apr 16, 2024, 05:17 PM |
| Broader Shelley G. | Director | Apr 12, 2024 | Option Exercise | $231.74 | 70 | 16,222 | 1,590 | Apr 16, 2024, 05:16 PM |
| Melenikiotou Georgia | Director | Apr 12, 2024 | Option Exercise | $231.74 | 56 | 12,977 | 1,386 | Apr 16, 2024, 05:13 PM |
| NELSON MARILYN C | Director | Apr 12, 2024 | Option Exercise | $231.74 | 107 | 24,796 | 34,445 | Apr 16, 2024, 05:11 PM |
| Herbert Timothy P. | CEO and President | Apr 01, 2024 | Sale | $205.09 | 40,000 | 8,203,581 | 94,270 | Apr 03, 2024, 09:52 PM |
| Herbert Timothy P. | CEO and President | Apr 01, 2024 | Sale | $205.09 | 40,000 | 8,203,581 | 94,270 | Apr 03, 2024, 07:44 PM |
| Griffin Jerry C | Director | Apr 01, 2024 | Option Exercise | $16.00 | 296 | 4,736 | 10,932 | Apr 03, 2024, 04:55 PM |
| Griffin Jerry C | Director | Apr 01, 2024 | Sale | $213.99 | 32 | 6,848 | 10,900 | Apr 03, 2024, 04:55 PM |
| NELSON MARILYN C | Director | Apr 01, 2024 | Option Exercise | $16.00 | 3,273 | 52,368 | 34,338 | Apr 02, 2024, 08:29 PM |
| NELSON MARILYN C | Director | Mar 27, 2024 | Option Exercise | $90.85 | 3,243 | 294,633 | 31,065 | Mar 29, 2024, 04:49 PM |
| Griffin Jerry C | Director | Mar 25, 2024 | Option Exercise | $16.00 | 1,000 | 16,000 | 11,190 | Mar 27, 2024, 04:01 PM |
| Griffin Jerry C | Director | Mar 25, 2024 | Sale | $197.81 | 554 | 109,587 | 11,136 | Mar 27, 2024, 04:01 PM |
| Rondoni John | Chief Technology Officer | Mar 22, 2024 | Sale | $194.40 | 4,387 | 852,849 | 14,832 | Mar 26, 2024, 08:23 PM |
| Griffin Jerry C | Director | Mar 18, 2024 | Option Exercise | $16.00 | 1,000 | 16,000 | 10,744 | Mar 20, 2024, 05:51 PM |
| Griffin Jerry C | Director | Mar 18, 2024 | Sale | $193.53 | 554 | 107,216 | 10,690 | Mar 20, 2024, 05:51 PM |
| Griffin Jerry C | Director | Mar 11, 2024 | Option Exercise | $16.00 | 1,000 | 16,000 | 10,298 | Mar 13, 2024, 09:21 PM |
| Griffin Jerry C | Director | Mar 11, 2024 | Sale | $198.05 | 554 | 109,720 | 10,244 | Mar 13, 2024, 09:21 PM |
| Griffin Jerry C | Director | Mar 01, 2024 | Option Exercise | $16.00 | 1,000 | 16,000 | 9,852 | Mar 05, 2024, 05:08 PM |
| Griffin Jerry C | Director | Mar 01, 2024 | Sale | $179.44 | 554 | 99,410 | 9,798 | Mar 05, 2024, 05:08 PM |
| NELSON MARILYN C | Director | Mar 01, 2024 | Option Exercise | $0.94 | 2,555 | 2,402 | 27,822 | Mar 05, 2024, 05:06 PM |
| Rondoni John | Chief Technology Officer | Feb 29, 2024 | Sale | $179.25 | 8,605 | 1,542,441 | 18,044 | Mar 04, 2024, 06:21 PM |
| Ban Randy | Chief Commercial Officer | Feb 27, 2024 | Option Exercise | $42.15 | 3,060 | 128,979 | 6,089 | Feb 27, 2024, 08:39 PM |
| Ban Randy | Chief Commercial Officer | Feb 23, 2024 | Option Exercise | $4.11 | 12,230 | 50,234 | 15,259 | Feb 27, 2024, 08:39 PM |
| Ban Randy | Chief Commercial Officer | Feb 27, 2024 | Sale | $182.01 | 3,060 | 556,951 | 3,029 | Feb 27, 2024, 08:39 PM |
| Ban Randy | Chief Commercial Officer | Feb 23, 2024 | Sale | $185.37 | 12,230 | 2,267,075 | 3,029 | Feb 27, 2024, 08:39 PM |
| Rondoni John | Chief Technology Officer | Feb 15, 2024 | Option Exercise | $2.07 | 8,000 | 16,560 | 24,262 | Feb 16, 2024, 04:05 PM |
| NELSON MARILYN C | Director | Feb 09, 2024 | Option Exercise | $0.94 | 4,000 | 3,760 | 25,267 | Feb 13, 2024, 04:01 PM |
| Phillips Bryan K | See Remarks | Jan 29, 2024 | Option Exercise | $216.61 | 205 | 44,405 | 1,877 | Jan 31, 2024, 08:48 PM |
| Jandrich Steven | VP, Human Resources | Jan 30, 2024 | Option Exercise | $0.94 | 16,225 | 15,251 | 23,096 | Jan 31, 2024, 08:40 PM |
| Sparks Charisse Y | Chief Medical Officer | Oct 12, 2023 | Buy | $153.50 | 100 | 15,350 | 998 | Jan 24, 2024, 04:32 PM |
| Melenikiotou Georgia | Director | Jan 16, 2024 | Option Exercise | $186.04 | 90 | 16,744 | 1,330 | Jan 18, 2024, 08:48 PM |
| NELSON MARILYN C | Director | Jan 16, 2024 | Option Exercise | $187.46 | 167 | 31,306 | 21,267 | Jan 18, 2024, 08:47 PM |
| Ellis Gary Lee | Director | Jan 16, 2024 | Option Exercise | $186.04 | 97 | 18,046 | 3,234 | Jan 18, 2024, 08:46 PM |
| Broader Shelley G. | Director | Jan 16, 2024 | Option Exercise | $186.04 | 97 | 18,046 | 1,520 | Jan 18, 2024, 08:45 PM |
| Sparks Charisse Y | Chief Medical Officer | Jan 16, 2024 | Option Exercise | $220.65 | 5 | 1,103 | 898 | Jan 18, 2024, 08:44 PM |
| Tansey Casey M | Director | Jan 16, 2024 | Option Exercise | $186.04 | 87 | 16,185 | 19,482 | Jan 18, 2024, 08:43 PM |
| NELSON MARILYN C | Director | Oct 13, 2023 | Option Exercise | $150.47 | 141 | 21,216 | 19,100 | Oct 17, 2023, 07:52 PM |
| NELSON MARILYN C | Director | Oct 17, 2023 | Option Exercise | $0.94 | 2,000 | 1,880 | 21,100 | Oct 17, 2023, 07:52 PM |
| Sparks Charisse Y | Director | Oct 13, 2023 | Option Exercise | $150.47 | 25 | 3,762 | 893 | Oct 17, 2023, 07:52 PM |
| Broader Shelley G. | Director | Oct 13, 2023 | Option Exercise | $150.47 | 99 | 14,897 | 1,423 | Oct 17, 2023, 07:50 PM |
| Tansey Casey M | Director | Oct 13, 2023 | Option Exercise | $150.47 | 87 | 13,091 | 20,395 | Oct 17, 2023, 07:49 PM |
| Melenikiotou Georgia | Director | Oct 13, 2023 | Option Exercise | $150.47 | 91 | 13,693 | 1,240 | Oct 17, 2023, 07:48 PM |
| Ellis Gary Lee | Director | Oct 13, 2023 | Option Exercise | $150.47 | 99 | 14,897 | 3,137 | Oct 17, 2023, 07:47 PM |
| Herbert Timothy P. | CEO and President | Oct 12, 2023 | Option Exercise | $147.96 | 87,962 | 13,014,741 | 172,315 | Oct 16, 2023, 07:53 PM |
| Herbert Timothy P. | CEO and President | Oct 12, 2023 | Option Exercise | $147.88 | 10,758 | 1,590,893 | 117,655 | Oct 16, 2023, 07:53 PM |
| Herbert Timothy P. | CEO and President | Oct 12, 2023 | Option Exercise | $10.38 | 21,762 | 225,890 | 128,413 | Oct 16, 2023, 07:53 PM |
| Herbert Timothy P. | CEO and President | Oct 12, 2023 | Option Exercise | $4.85 | 186,274 | 902,922 | 203,691 | Oct 16, 2023, 07:53 PM |
| NELSON MARILYN C | Director | Sep 21, 2023 | Option Exercise | $0.94 | 2,000 | 1,880 | 18,959 | Sep 25, 2023, 06:30 PM |
| NELSON MARILYN C | Director | Sep 14, 2023 | Option Exercise | $0.94 | 2,000 | 1,880 | 16,959 | Sep 18, 2023, 04:35 PM |
| Jandrich Steven | VP, Human Resources | Aug 28, 2023 | Option Exercise | $0.94 | 2,500 | 2,350 | 6,871 | Aug 30, 2023, 07:40 PM |
| Herbert Timothy P. | CEO and President | Aug 23, 2023 | Option Exercise | $70.55 | 953 | 67,230 | 107,784 | Aug 28, 2023, 08:03 AM |
| NELSON MARILYN C | Director | Aug 21, 2023 | Option Exercise | $0.94 | 2,000 | 1,880 | 14,959 | Aug 22, 2023, 04:05 PM |
| NELSON MARILYN C | Director | Aug 10, 2023 | Option Exercise | $0.94 | 2,000 | 1,880 | 12,959 | Aug 11, 2023, 04:01 PM |
| NELSON MARILYN C | Director | Aug 07, 2023 | Option Exercise | $0.94 | 2,000 | 1,880 | 10,959 | Aug 09, 2023, 04:05 PM |
| NELSON MARILYN C | Director | Aug 04, 2023 | Option Exercise | $0.94 | 2,000 | 1,880 | 8,959 | Aug 08, 2023, 05:00 PM |
| Griffin Jerry C | Director | Jul 31, 2023 | Option Exercise | $16.00 | 1,000 | 16,000 | 9,381 | Aug 01, 2023, 06:26 PM |
| Griffin Jerry C | Director | Jul 31, 2023 | Sale | $290.47 | 529 | 153,659 | 9,352 | Aug 01, 2023, 06:26 PM |
| NELSON MARILYN C | Director | Jul 24, 2023 | Option Exercise | $0.94 | 2,000 | 1,880 | 6,959 | Jul 27, 2023, 06:29 PM |
| Griffin Jerry C | Director | Jul 24, 2023 | Option Exercise | $16.00 | 1,000 | 16,000 | 8,910 | Jul 26, 2023, 04:15 PM |
| Griffin Jerry C | Director | Jul 24, 2023 | Sale | $304.99 | 529 | 161,340 | 8,881 | Jul 26, 2023, 04:15 PM |
| Tansey Casey M | Director | Jul 17, 2023 | Option Exercise | $325.91 | 40 | 13,036 | 20,308 | Jul 19, 2023, 04:52 PM |
| NELSON MARILYN C | Director | Jul 17, 2023 | Option Exercise | $325.91 | 65 | 21,184 | 4,959 | Jul 19, 2023, 04:51 PM |
| Griffin Jerry C | Director | Jul 17, 2023 | Option Exercise | $16.00 | 1,000 | 16,000 | 8,439 | Jul 19, 2023, 04:50 PM |
| Griffin Jerry C | Director | Jul 17, 2023 | Sale | $326.84 | 529 | 172,898 | 8,410 | Jul 19, 2023, 04:50 PM |
| Melenikiotou Georgia | Director | Jul 17, 2023 | Option Exercise | $325.91 | 42 | 13,688 | 1,149 | Jul 19, 2023, 04:48 PM |
| Ellis Gary Lee | Director | Jul 17, 2023 | Option Exercise | $325.91 | 46 | 14,992 | 3,038 | Jul 19, 2023, 04:47 PM |
| Broader Shelley G. | Director | Jul 17, 2023 | Option Exercise | $325.91 | 46 | 14,992 | 1,324 | Jul 19, 2023, 04:46 PM |
| Sparks Charisse Y | Director | Jul 17, 2023 | Option Exercise | $325.91 | 40 | 13,036 | 868 | Jul 19, 2023, 04:43 PM |
| Griffin Jerry C | Director | Jul 10, 2023 | Option Exercise | $16.00 | 1,000 | 16,000 | 7,968 | Jul 12, 2023, 06:00 PM |
| Griffin Jerry C | Director | Jul 10, 2023 | Sale | $310.42 | 529 | 164,212 | 7,939 | Jul 12, 2023, 06:00 PM |
| Griffin Jerry C | Director | Jul 03, 2023 | Option Exercise | $16.00 | 1,000 | 16,000 | 7,497 | Jul 06, 2023, 05:26 PM |
| Griffin Jerry C | Director | Jul 03, 2023 | Sale | $322.09 | 529 | 170,386 | 7,468 | Jul 06, 2023, 05:26 PM |
| Griffin Jerry C | Director | Jun 26, 2023 | Option Exercise | $16.00 | 1,000 | 16,000 | 7,026 | Jun 28, 2023, 06:21 PM |
| Griffin Jerry C | Director | Jun 26, 2023 | Sale | $315.87 | 529 | 167,095 | 6,997 | Jun 28, 2023, 06:21 PM |
| Griffin Jerry C | Director | Jun 20, 2023 | Option Exercise | $16.00 | 1,000 | 16,000 | 6,555 | Jun 22, 2023, 04:07 PM |
| Griffin Jerry C | Director | Jun 20, 2023 | Sale | $307.64 | 529 | 162,742 | 6,526 | Jun 22, 2023, 04:07 PM |
| Griffin Jerry C | Director | Jun 12, 2023 | Option Exercise | $16.00 | 1,000 | 16,000 | 6,084 | Jun 14, 2023, 05:56 PM |
| Griffin Jerry C | Director | Jun 12, 2023 | Sale | $309.03 | 529 | 163,477 | 6,055 | Jun 14, 2023, 05:56 PM |
| Griffin Jerry C | Director | Jun 05, 2023 | Option Exercise | $16.00 | 1,000 | 16,000 | 5,613 | Jun 07, 2023, 05:57 PM |
| Griffin Jerry C | Director | Jun 05, 2023 | Sale | $305.69 | 529 | 161,710 | 5,584 | Jun 07, 2023, 05:57 PM |
| Griffin Jerry C | Director | May 30, 2023 | Option Exercise | $16.00 | 1,000 | 16,000 | 5,142 | Jun 01, 2023, 05:59 PM |
| Griffin Jerry C | Director | May 30, 2023 | Sale | $294.90 | 529 | 156,002 | 5,113 | Jun 01, 2023, 05:59 PM |
| Griffin Jerry C | Director | May 22, 2023 | Option Exercise | $16.00 | 1,000 | 16,000 | 4,671 | May 24, 2023, 04:04 PM |
| Griffin Jerry C | Director | May 22, 2023 | Sale | $307.52 | 529 | 162,678 | 4,642 | May 24, 2023, 04:04 PM |
| Griffin Jerry C | Director | May 15, 2023 | Option Exercise | $16.00 | 1,000 | 16,000 | 4,200 | May 17, 2023, 08:23 PM |
| Griffin Jerry C | Director | May 15, 2023 | Sale | $293.91 | 529 | 155,478 | 4,171 | May 17, 2023, 08:23 PM |
| Jandrich Steven | VP, Human Resources | May 12, 2023 | Option Exercise | $71.00 | 4,525 | 321,275 | 8,896 | May 16, 2023, 05:32 PM |
| Jandrich Steven | VP, Human Resources | May 12, 2023 | Sale | $292.84 | 4,525 | 1,325,107 | 7,603 | May 16, 2023, 05:32 PM |
| Jandrich Steven | VP, Human Resources | May 08, 2023 | Option Exercise | $42.15 | 1,727 | 72,793 | 6,098 | May 10, 2023, 08:17 PM |
| Jandrich Steven | VP, Human Resources | May 08, 2023 | Sale | $280.12 | 1,727 | 483,767 | 4,371 | May 10, 2023, 08:17 PM |
| Griffin Jerry C | Director | May 08, 2023 | Option Exercise | $16.00 | 1,000 | 16,000 | 3,729 | May 10, 2023, 08:16 PM |
| Griffin Jerry C | Director | May 08, 2023 | Sale | $280.00 | 529 | 148,120 | 3,700 | May 10, 2023, 08:16 PM |
| Jandrich Steven | VP, Human Resources | Apr 25, 2023 | Option Exercise | $42.15 | 8,000 | 337,200 | 12,371 | May 03, 2023, 04:35 PM |
| Jandrich Steven | VP, Human Resources | Apr 25, 2023 | Sale | $271.02 | 8,000 | 2,168,164 | 6,872 | May 03, 2023, 04:35 PM |
| Tansey Casey M | Director | Apr 10, 2023 | Option Exercise | $231.77 | 56 | 12,979 | 19,599 | Apr 12, 2023, 04:11 PM |
| Sparks Charisse Y | Director | Apr 10, 2023 | Option Exercise | $231.77 | 56 | 12,979 | 159 | Apr 12, 2023, 04:09 PM |
| Melenikiotou Georgia | Director | Apr 10, 2023 | Option Exercise | $231.77 | 59 | 13,674 | 438 | Apr 12, 2023, 04:07 PM |
| NELSON MARILYN C | Director | Apr 10, 2023 | Option Exercise | $231.77 | 91 | 21,091 | 4,225 | Apr 12, 2023, 04:06 PM |
| Broader Shelley G. | Director | Apr 10, 2023 | Option Exercise | $231.77 | 64 | 14,833 | 609 | Apr 12, 2023, 04:06 PM |
| Ellis Gary Lee | Director | Apr 10, 2023 | Option Exercise | $231.77 | 64 | 14,833 | 2,323 | Apr 12, 2023, 04:05 PM |
| McCormick Shawn | Director | Mar 17, 2023 | Option Exercise | $0.94 | 4,000 | 3,760 | 11,518 | Mar 21, 2023, 04:05 PM |
| Herbert Timothy P. | CEO and President | Mar 29, 2022 | Sale | $252.39 | 8,017 | 2,023,411 | 106,773 | Mar 13, 2023, 04:56 PM |
| Herbert Timothy P. | CEO and President | Mar 29, 2022 | Sale | $251.14 | 15,084 | 3,788,249 | 105,123 | Mar 13, 2023, 04:56 PM |
| Herbert Timothy P. | CEO and President | Mar 29, 2022 | Sale | $250.20 | 74,315 | 18,593,613 | 40,990 | Mar 13, 2023, 04:56 PM |
| Herbert Timothy P. | CEO and President | Mar 17, 2022 | Sale | $225.35 | 18,771 | 4,230,073 | 114,790 | Mar 13, 2023, 04:55 PM |
| Herbert Timothy P. | CEO and President | Mar 17, 2022 | Sale | $226.17 | 1,229 | 277,964 | 118,778 | Mar 13, 2023, 04:55 PM |
| Herbert Timothy P. | CEO and President | Feb 15, 2023 | Sale | $275.17 | 11,715 | 3,223,617 | 17,889 | Mar 13, 2023, 04:51 PM |
| Herbert Timothy P. | CEO and President | Feb 14, 2023 | Sale | $275.52 | 20,138 | 5,548,477 | 31,100 | Mar 13, 2023, 04:51 PM |
| Rondoni John | Chief Technology Officer | Mar 08, 2023 | Option Exercise | $2.07 | 4,387 | 9,081 | 13,478 | Mar 10, 2023, 05:24 PM |
| Ebeling Philip | Chief Operating Officer | Feb 16, 2023 | Option Exercise | $194.82 | 7,000 | 1,363,740 | 7,243 | Feb 21, 2023, 06:54 PM |
| Ebeling Philip | Chief Operating Officer | Feb 16, 2023 | Sale | $275.00 | 7,000 | 1,925,000 | 243 | Feb 21, 2023, 06:54 PM |
| Herbert Timothy P. | CEO and President | Feb 13, 2023 | Sale | $275.05 | 2,619 | 720,356 | 9,728 | Feb 14, 2023, 07:51 PM |
| Herbert Timothy P. | CEO and President | Feb 09, 2023 | Sale | $275.12 | 7,028 | 1,933,543 | 12,347 | Feb 10, 2023, 06:36 PM |
| Herbert Timothy P. | CEO and President | Feb 08, 2023 | Sale | $275.00 | 3,500 | 962,500 | 19,375 | Feb 10, 2023, 06:36 PM |
| Rondoni John | Chief Technology Officer | Feb 08, 2023 | Sale | $268.12 | 2,500 | 670,300 | 10,651 | Feb 08, 2023, 05:12 PM |
| Rondoni John | Chief Technology Officer | Feb 06, 2023 | Sale | $250.20 | 3,500 | 875,710 | 14,601 | Feb 08, 2023, 05:12 PM |
| Phillips Bryan K | See Remarks | Jan 29, 2023 | Option Exercise | $253.24 | 205 | 51,914 | 1,960 | Jan 31, 2023, 07:15 PM |
| Buchholz Richard | Chief Financial Officer | Jan 25, 2023 | Option Exercise | $25.57 | 6,100 | 155,967 | 40,487 | Jan 27, 2023, 08:00 PM |
| Jandrich Steven | VP, Human Resources | Jan 23, 2023 | Option Exercise | $0.94 | 500 | 470 | 4,755 | Jan 25, 2023, 04:05 PM |
| NELSON MARILYN C | Director | Jan 10, 2023 | Option Exercise | $248.31 | 85 | 21,106 | 4,134 | Jan 19, 2023, 07:58 PM |
| Broader Shelley G. | Director | Jan 10, 2023 | Option Exercise | $248.31 | 60 | 14,899 | 545 | Jan 19, 2023, 07:57 PM |
| Melenikiotou Georgia | Director | Jan 10, 2023 | Option Exercise | $248.31 | 55 | 13,657 | 379 | Jan 19, 2023, 07:56 PM |
| Ellis Gary Lee | Director | Jan 10, 2023 | Option Exercise | $248.31 | 60 | 14,899 | 2,259 | Jan 19, 2023, 07:55 PM |
| Sparks Charisse Y | Director | Jan 10, 2023 | Option Exercise | $248.31 | 52 | 12,912 | 103 | Jan 19, 2023, 07:54 PM |
| Tansey Casey M | Director | Jan 10, 2023 | Option Exercise | $248.31 | 52 | 12,912 | 19,543 | Jan 19, 2023, 07:53 PM |
| Buchholz Richard | Chief Financial Officer | Jan 13, 2023 | Sale | $250.03 | 11,977 | 2,994,609 | 34,387 | Jan 13, 2023, 04:59 PM |
| Buchholz Richard | Chief Financial Officer | Jan 11, 2023 | Sale | $250.00 | 523 | 130,750 | 46,364 | Jan 13, 2023, 04:59 PM |
| Rondoni John | Chief Technology Officer | Jan 03, 2023 | Sale | $256.00 | 1,170 | 299,520 | 15,091 | Jan 09, 2023, 09:20 PM |
| Ban Randy | Chief Commercial Officer | Jan 03, 2023 | Option Exercise | $0.94 | 10,000 | 9,400 | 10,304 | Jan 05, 2023, 07:01 PM |
| Ban Randy | Chief Commercial Officer | Jan 03, 2023 | Sale | $252.10 | 10,000 | 2,520,953 | 7,904 | Jan 05, 2023, 07:01 PM |
| Rondoni John | Chief Technology Officer | Dec 19, 2022 | Sale | $251.72 | 678 | 170,666 | 16,230 | Dec 21, 2022, 04:05 PM |
| NELSON MARILYN C | Director | Dec 16, 2022 | Sale | $244.77 | 25,211 | 6,170,843 | 74,097 | Dec 20, 2022, 05:43 PM |
| Ban Randy | Chief Commercial Officer | Dec 02, 2022 | Option Exercise | $0.94 | 10,333 | 9,713 | 10,618 | Dec 06, 2022, 04:15 PM |
| Ban Randy | Chief Commercial Officer | Dec 05, 2022 | Sale | $235.87 | 10,333 | 2,437,264 | 5,430 | Dec 06, 2022, 04:15 PM |
| Griffin Jerry C | Director | Nov 11, 2022 | Option Exercise | $0.94 | 11,277 | 10,600 | 11,277 | Nov 14, 2022, 09:13 PM |
| Griffin Jerry C | Director | Nov 11, 2022 | Sale | $221.42 | 9,217 | 2,040,853 | 5,326 | Nov 14, 2022, 09:13 PM |
| Jandrich Steven | VP, Human Resources | Oct 17, 2022 | Option Exercise | $0.94 | 750 | 705 | 4,255 | Oct 19, 2022, 04:16 PM |
| Herbert Timothy P. | CEO and President | Oct 11, 2022 | Option Exercise | $4.74 | 68,787 | 326,264 | 159,937 | Oct 13, 2022, 06:31 PM |
| Broader Shelley G. | Director | Oct 11, 2022 | Option Exercise | $168.98 | 85 | 14,363 | 485 | Oct 13, 2022, 04:26 PM |
| NELSON MARILYN C | Director | Oct 11, 2022 | Option Exercise | $168.98 | 129 | 21,798 | 4,049 | Oct 13, 2022, 04:25 PM |
| Melenikiotou Georgia | Director | Oct 11, 2022 | Option Exercise | $168.98 | 81 | 13,687 | 324 | Oct 13, 2022, 04:23 PM |
| Ellis Gary Lee | Director | Oct 11, 2022 | Option Exercise | $168.98 | 88 | 14,870 | 2,199 | Oct 13, 2022, 04:21 PM |
| Sparks Charisse Y | Director | Oct 11, 2022 | Option Exercise | $168.98 | 51 | 8,618 | 51 | Oct 13, 2022, 04:20 PM |
| Tansey Casey M | Director | Oct 11, 2022 | Option Exercise | $168.98 | 81 | 13,687 | 19,491 | Oct 13, 2022, 04:19 PM |
| Rondoni John | Chief Technology Officer | Sep 23, 2022 | Option Exercise | $0.94 | 6,218 | 5,845 | 16,828 | Oct 04, 2022, 05:11 PM |
| Melenikiotou Georgia | Director | Jul 11, 2022 | Option Exercise | $193.86 | 70 | 13,570 | 243 | Jul 13, 2022, 06:12 PM |
| NELSON MARILYN C | Director | Jul 11, 2022 | Option Exercise | $193.86 | 119 | 23,069 | 3,920 | Jul 13, 2022, 06:11 PM |
| Ellis Gary Lee | Director | Jul 11, 2022 | Option Exercise | $193.86 | 77 | 14,927 | 2,111 | Jul 13, 2022, 06:10 PM |
| Tansey Casey M | Director | Jul 11, 2022 | Option Exercise | $193.86 | 77 | 14,927 | 19,410 | Jul 13, 2022, 06:09 PM |
| Broader Shelley G. | Director | Jul 11, 2022 | Option Exercise | $193.86 | 67 | 12,989 | 400 | Jul 13, 2022, 06:07 PM |
| Herbert Timothy P. | CEO and President | Apr 18, 2022 | Option Exercise | $1.31 | 17,417 | 22,898 | 22,641 | Apr 22, 2022, 07:56 PM |
| Melenikiotou Georgia | Director | Apr 08, 2022 | Option Exercise | $254.08 | 54 | 13,720 | 173 | Apr 12, 2022, 08:47 PM |
| Tansey Casey M | Director | Apr 08, 2022 | Option Exercise | $254.08 | 59 | 14,991 | 19,333 | Apr 12, 2022, 08:46 PM |
| Broader Shelley G. | Director | Apr 08, 2022 | Option Exercise | $254.08 | 51 | 12,958 | 333 | Apr 12, 2022, 08:45 PM |
| Ellis Gary Lee | Director | Apr 08, 2022 | Option Exercise | $254.08 | 59 | 14,991 | 2,034 | Apr 12, 2022, 08:44 PM |
| NELSON MARILYN C | Director | Apr 08, 2022 | Option Exercise | $254.08 | 91 | 23,121 | 3,801 | Apr 12, 2022, 08:44 PM |
| NELSON MARILYN C | Director | Apr 01, 2022 | Sale | $267.50 | 10,000 | 2,675,000 | 81,130 | Apr 08, 2022, 04:15 PM |
| Buchholz Richard | Chief Financial Officer | Apr 01, 2022 | Sale | $258.67 | 15,000 | 3,880,104 | 56,676 | Apr 05, 2022, 07:41 PM |
| Herbert Timothy P. | CEO and President | Mar 25, 2022 | Sale | $250.00 | 695 | 173,750 | 120,455 | Mar 29, 2022, 08:31 PM |
| Herbert Timothy P. | CEO and President | Mar 29, 2022 | Sale | $250.53 | 97,416 | 24,405,159 | 37,582 | Mar 29, 2022, 08:31 PM |
| Herbert Timothy P. | CEO and President | Mar 28, 2022 | Sale | $250.00 | 2,542 | 635,500 | 120,291 | Mar 29, 2022, 08:31 PM |
| Herbert Timothy P. | CEO and President | Mar 25, 2022 | Sale | $250.00 | 42 | 10,500 | 122,833 | Mar 29, 2022, 08:31 PM |
| Herbert Timothy P. | CEO and President | Mar 29, 2022 | Sale | $250.61 | 27,759 | 6,956,592 | 95,996 | Mar 29, 2022, 08:31 PM |
| Herbert Timothy P. | CEO and President | Mar 28, 2022 | Sale | $250.00 | 1,546 | 386,500 | 118,909 | Mar 29, 2022, 08:31 PM |
| NELSON MARILYN C | Director | Mar 29, 2022 | Sale | $257.43 | 10,098 | 2,599,550 | 91,228 | Mar 29, 2022, 08:24 PM |
| NELSON MARILYN C | Director | Mar 28, 2022 | Sale | $250.00 | 2,323 | 580,750 | 96,228 | Mar 29, 2022, 08:24 PM |
| NELSON MARILYN C | Director | Mar 25, 2022 | Sale | $250.01 | 2,579 | 644,776 | 98,551 | Mar 29, 2022, 08:24 PM |
| Herbert Timothy P. | CEO and President | Mar 17, 2022 | Sale | $225.40 | 20,000 | 4,508,040 | 122,419 | Mar 21, 2022, 05:43 PM |
| Herbert Timothy P. | CEO and President | Jan 27, 2022 | Option Exercise | $2.07 | 37,993 | 78,646 | 140,900 | Jan 31, 2022, 04:23 PM |
| Phillips Bryan K | See Remarks | Jan 29, 2022 | Option Exercise | $208.00 | 205 | 42,640 | 2,070 | Jan 31, 2022, 04:20 PM |
| Herbert Timothy P. | CEO and President | Jan 24, 2022 | Option Exercise | $1.70 | 37,062 | 63,088 | 102,907 | Jan 26, 2022, 08:52 PM |
| Broader Shelley G. | Director | Jan 10, 2022 | Option Exercise | $227.56 | 57 | 12,971 | 282 | Jan 12, 2022, 04:18 PM |
| NELSON MARILYN C | Director | Jan 10, 2022 | Option Exercise | $227.56 | 101 | 22,984 | 3,710 | Jan 12, 2022, 04:17 PM |
| Melenikiotou Georgia | Director | Jan 10, 2022 | Option Exercise | $227.56 | 60 | 13,654 | 119 | Jan 12, 2022, 04:16 PM |
| Ellis Gary Lee | Director | Jan 10, 2022 | Option Exercise | $227.56 | 65 | 14,791 | 1,975 | Jan 12, 2022, 04:16 PM |
| Tansey Casey M | Director | Jan 10, 2022 | Option Exercise | $227.56 | 65 | 14,791 | 19,274 | Jan 12, 2022, 04:15 PM |
| Ban Randy | Chief Commercial Officer | Jan 05, 2022 | Option Exercise | $2.07 | 3,532 | 7,311 | 3,798 | Jan 06, 2022, 04:15 PM |
| Ban Randy | Chief Commercial Officer | Jan 04, 2022 | Option Exercise | $1.78 | 6,775 | 12,058 | 7,041 | Jan 06, 2022, 04:15 PM |
| Ban Randy | Chief Commercial Officer | Jan 05, 2022 | Sale | $244.67 | 3,532 | 864,174 | 266 | Jan 06, 2022, 04:15 PM |
| Ban Randy | Chief Commercial Officer | Jan 04, 2022 | Sale | $240.00 | 6,775 | 1,626,000 | 266 | Jan 06, 2022, 04:15 PM |
| Ban Randy | Chief Commercial Officer | Dec 23, 2021 | Option Exercise | $1.33 | 8,342 | 11,066 | 8,590 | Dec 28, 2021, 05:32 PM |
| Ban Randy | Chief Commercial Officer | Dec 27, 2021 | Option Exercise | $1.45 | 1,418 | 2,063 | 1,666 | Dec 28, 2021, 05:32 PM |
| Ban Randy | Chief Commercial Officer | Dec 23, 2021 | Sale | $240.00 | 8,342 | 2,002,080 | 248 | Dec 28, 2021, 05:32 PM |
| Ban Randy | Chief Commercial Officer | Dec 27, 2021 | Sale | $240.00 | 1,418 | 340,320 | 248 | Dec 28, 2021, 05:32 PM |
| NELSON MARILYN C | Director | Dec 07, 2021 | Sale | $215.00 | 25,106 | 5,397,790 | 101,130 | Dec 09, 2021, 04:15 PM |
| Jandrich Steven | VP, Human Resources | Oct 15, 2021 | Option Exercise | $0.94 | 2,000 | 1,880 | 3,505 | Oct 19, 2021, 04:11 PM |
| Broader Shelley G. | Director | Oct 08, 2021 | Option Exercise | $231.04 | 56 | 12,938 | 225 | Oct 13, 2021, 04:50 PM |
| Melenikiotou Georgia | Director | Oct 08, 2021 | Option Exercise | $231.04 | 59 | 13,631 | 59 | Oct 13, 2021, 04:49 PM |
| Ellis Gary Lee | Director | Oct 08, 2021 | Option Exercise | $231.04 | 64 | 14,787 | 1,910 | Oct 13, 2021, 04:48 PM |
| Tansey Casey M | Director | Oct 08, 2021 | Option Exercise | $231.04 | 64 | 14,787 | 19,209 | Oct 13, 2021, 04:47 PM |
| NELSON MARILYN C | Director | Oct 08, 2021 | Option Exercise | $231.04 | 100 | 23,104 | 3,609 | Oct 13, 2021, 04:46 PM |
| Buchholz Richard | Chief Financial Officer | Sep 28, 2021 | Option Exercise | $20.46 | 4,755 | 97,306 | 62,624 | Sep 30, 2021, 04:23 PM |
| Melenikiotou Georgia | Director | Aug 20, 2021 | Option Exercise | $93.14 | 426 | 39,678 | 566 | Aug 24, 2021, 06:09 PM |
| Melenikiotou Georgia | Director | Aug 20, 2021 | Sale | $212.22 | 566 | 120,116 | 140 | Aug 24, 2021, 06:09 PM |
| Melenikiotou Georgia | Director | Aug 18, 2021 | Option Exercise | $93.14 | 852 | 79,355 | 1,132 | Aug 20, 2021, 04:05 PM |
| Melenikiotou Georgia | Director | Aug 18, 2021 | Sale | $207.08 | 852 | 176,432 | 280 | Aug 20, 2021, 04:05 PM |
| Melenikiotou Georgia | Director | Aug 19, 2021 | Sale | $206.97 | 140 | 28,976 | 140 | Aug 20, 2021, 04:05 PM |
| Broader Shelley G. | Director | Jul 09, 2021 | Option Exercise | $185.73 | 68 | 12,630 | 169 | Jul 13, 2021, 05:12 PM |
| NELSON MARILYN C | Director | Jul 09, 2021 | Option Exercise | $185.73 | 120 | 22,288 | 3,509 | Jul 13, 2021, 05:11 PM |
| Melenikiotou Georgia | Director | Jul 09, 2021 | Option Exercise | $185.73 | 71 | 13,187 | 280 | Jul 13, 2021, 05:10 PM |
| Ellis Gary Lee | Director | Jul 09, 2021 | Option Exercise | $185.73 | 78 | 14,487 | 1,846 | Jul 13, 2021, 05:08 PM |
| Tansey Casey M | Director | Jul 09, 2021 | Option Exercise | $185.73 | 78 | 14,487 | 19,145 | Jul 13, 2021, 05:05 PM |
| NELSON MARILYN C | Director | Apr 09, 2021 | Option Exercise | $218.45 | 94 | 20,534 | 3,389 | Apr 13, 2021, 04:16 PM |
| Melenikiotou Georgia | Director | Apr 09, 2021 | Option Exercise | $218.45 | 57 | 12,452 | 209 | Apr 13, 2021, 04:16 PM |
| Ellis Gary Lee | Director | Apr 09, 2021 | Option Exercise | $218.45 | 62 | 13,544 | 1,768 | Apr 13, 2021, 04:15 PM |
| Tansey Casey M | Director | Apr 09, 2021 | Option Exercise | $218.45 | 62 | 13,544 | 19,067 | Apr 13, 2021, 04:15 PM |
| Buchholz Richard | Chief Financial Officer | Mar 12, 2021 | Option Exercise | $34.21 | 12,500 | 427,611 | 57,789 | Mar 16, 2021, 04:11 PM |
| Jandrich Steven | VP, Human Resources | Feb 26, 2021 | Option Exercise | $40.74 | 10,000 | 407,362 | 11,505 | Mar 01, 2021, 05:41 PM |
| Jandrich Steven | VP, Human Resources | Feb 26, 2021 | Sale | $235.00 | 10,000 | 2,350,000 | 1,505 | Mar 01, 2021, 05:41 PM |
| Buchholz Richard | Chief Financial Officer | Feb 25, 2021 | Sale | $225.74 | 20,000 | 4,514,804 | 65,069 | Mar 01, 2021, 05:39 PM |
| Broader Shelley G. | Director | Jan 08, 2021 | Option Exercise | $194.10 | 47 | 9,123 | 47 | Jan 12, 2021, 04:17 PM |
| Tansey Casey M | Director | Jan 08, 2021 | Option Exercise | $194.10 | 70 | 13,587 | 19,005 | Jan 12, 2021, 04:16 PM |
| NELSON MARILYN C | Director | Jan 08, 2021 | Option Exercise | $194.10 | 106 | 20,575 | 3,295 | Jan 12, 2021, 04:16 PM |
| Ellis Gary Lee | Director | Jan 08, 2021 | Option Exercise | $194.10 | 70 | 13,587 | 1,706 | Jan 12, 2021, 04:15 PM |
| Melenikiotou Georgia | Director | Jan 08, 2021 | Option Exercise | $194.10 | 64 | 12,422 | 152 | Jan 12, 2021, 04:15 PM |
| Ban Randy | Chief Commercial Officer | Jan 04, 2021 | Option Exercise | $1.60 | 30,187 | 48,363 | 30,416 | Jan 06, 2021, 04:58 PM |
| Ban Randy | Chief Commercial Officer | Jan 04, 2021 | Sale | $182.15 | 30,187 | 5,498,447 | 23,069 | Jan 06, 2021, 04:58 PM |
| Buchholz Richard | Chief Financial Officer | Dec 15, 2020 | Sale | $190.53 | 3,000 | 571,589 | 68,551 | Dec 16, 2020, 05:50 PM |
| Buchholz Richard | Chief Financial Officer | Nov 17, 2020 | Sale | $171.66 | 3,000 | 514,986 | 71,551 | Nov 19, 2020, 04:15 PM |
| Herbert Timothy P. | CEO and President | Nov 05, 2020 | Sale | $163.74 | 80,000 | 13,099,424 | 189,424 | Nov 09, 2020, 04:15 PM |
| NELSON MARILYN C | Director | Nov 03, 2020 | Sale | $144.65 | 7,000 | 1,012,550 | 138,017 | Nov 05, 2020, 04:19 PM |
| Buchholz Richard | Chief Financial Officer | Oct 20, 2020 | Sale | $122.84 | 3,000 | 368,510 | 72,951 | Oct 22, 2020, 04:19 PM |
| NELSON MARILYN C | Director | Oct 09, 2020 | Sale | $130.00 | 1,000 | 130,000 | 145,017 | Oct 16, 2020, 05:38 PM |
| NELSON MARILYN C | Director | Oct 08, 2020 | Sale | $130.96 | 25,000 | 3,273,977 | 166,419 | Oct 16, 2020, 05:38 PM |
| Melenikiotou Georgia | Director | Oct 09, 2020 | Option Exercise | $130.00 | 88 | 11,440 | 88 | Oct 13, 2020, 04:17 PM |
| Tansey Casey M | Director | Oct 09, 2020 | Option Exercise | $130.00 | 105 | 13,650 | 18,935 | Oct 13, 2020, 04:17 PM |
| Ellis Gary Lee | Director | Oct 09, 2020 | Option Exercise | $130.00 | 105 | 13,650 | 1,636 | Oct 13, 2020, 04:17 PM |
| Khuong Chau Quang | Director | Oct 09, 2020 | Option Exercise | $130.00 | 91 | 11,830 | 1,875 | Oct 13, 2020, 04:16 PM |
| NELSON MARILYN C | Director | Oct 09, 2020 | Option Exercise | $130.00 | 158 | 20,540 | 3,189 | Oct 13, 2020, 04:15 PM |
| Buchholz Richard | Chief Financial Officer | Oct 09, 2020 | Option Exercise | $29.94 | 8,267 | 247,489 | 74,651 | Oct 13, 2020, 08:00 AM |
| Buchholz Richard | Chief Financial Officer | Sep 22, 2020 | Sale | $126.09 | 6,000 | 756,556 | 71,884 | Sep 24, 2020, 04:17 PM |
| Tansey Casey M | Director | Sep 14, 2020 | Sale | $129.27 | 12,000 | 1,551,211 | 27,010 | Sep 16, 2020, 05:47 PM |
| Ban Randy | Chief Commercial Officer | Sep 09, 2020 | Option Exercise | $1.14 | 30,000 | 34,200 | 30,189 | Sep 11, 2020, 04:15 PM |
| Ban Randy | Chief Commercial Officer | Sep 09, 2020 | Sale | $117.54 | 30,000 | 3,526,268 | 5,381 | Sep 11, 2020, 04:15 PM |
| Griffin Jerry C | Director | Aug 27, 2020 | Sale | $115.34 | 28,800 | 3,321,732 | 17,548 | Aug 28, 2020, 04:15 PM |
| Jandrich Steven | Chief Comp Off & VP, Human Res | Aug 18, 2020 | Option Exercise | $31.70 | 3,000 | 95,093 | 4,805 | Aug 20, 2020, 04:15 PM |
| Jandrich Steven | Chief Comp Off & VP, Human Res | Aug 18, 2020 | Sale | $110.00 | 3,000 | 330,000 | 1,805 | Aug 20, 2020, 04:15 PM |
| ORBIMED ADVISORS LLC | Director | Aug 18, 2020 | Sale | $108.54 | 43,543 | 4,726,157 | 0 | Aug 19, 2020, 05:24 PM |
| ORBIMED ADVISORS LLC | Director | Aug 17, 2020 | Sale | $107.49 | 94,900 | 10,200,801 | 43,543 | Aug 19, 2020, 05:24 PM |
| Khuong Chau Quang | Director | Aug 18, 2020 | Sale | $108.54 | 43,543 | 4,726,157 | 0 | Aug 19, 2020, 05:19 PM |
| Khuong Chau Quang | Director | Aug 17, 2020 | Sale | $107.49 | 94,900 | 10,200,801 | 43,543 | Aug 19, 2020, 05:19 PM |
| Khuong Chau Quang | Director | Aug 14, 2020 | Sale | $109.03 | 20,237 | 2,206,440 | 138,443 | Aug 14, 2020, 05:22 PM |
| Khuong Chau Quang | Director | Aug 13, 2020 | Sale | $109.93 | 29,251 | 3,215,562 | 158,500 | Aug 14, 2020, 05:22 PM |
| Khuong Chau Quang | Director | Aug 12, 2020 | Sale | $107.45 | 42,679 | 4,585,858 | 187,751 | Aug 14, 2020, 05:22 PM |
| ORBIMED ADVISORS LLC | Director | Aug 14, 2020 | Sale | $109.03 | 20,257 | 2,208,621 | 138,443 | Aug 14, 2020, 05:19 PM |
| ORBIMED ADVISORS LLC | Director | Aug 13, 2020 | Sale | $109.93 | 29,251 | 3,215,562 | 158,500 | Aug 14, 2020, 05:19 PM |
| ORBIMED ADVISORS LLC | Director | Aug 12, 2020 | Sale | $107.45 | 42,679 | 4,585,858 | 187,751 | Aug 14, 2020, 05:19 PM |
| ORBIMED ADVISORS LLC | Director | Aug 11, 2020 | Sale | $105.78 | 39,877 | 4,218,189 | 230,430 | Aug 11, 2020, 06:23 PM |
| ORBIMED ADVISORS LLC | Director | Aug 10, 2020 | Sale | $105.23 | 47,700 | 5,019,471 | 270,307 | Aug 11, 2020, 06:23 PM |
| ORBIMED ADVISORS LLC | Director | Aug 07, 2020 | Sale | $106.18 | 28,993 | 3,078,477 | 318,007 | Aug 11, 2020, 06:23 PM |
| Khuong Chau Quang | Director | Aug 11, 2020 | Sale | $105.78 | 39,877 | 4,218,189 | 230,430 | Aug 11, 2020, 06:19 PM |
| Khuong Chau Quang | Director | Aug 10, 2020 | Sale | $105.23 | 47,700 | 5,019,471 | 270,307 | Aug 11, 2020, 06:19 PM |
| Khuong Chau Quang | Director | Aug 07, 2020 | Sale | $106.18 | 28,993 | 3,078,477 | 318,007 | Aug 11, 2020, 06:19 PM |
| Herbert Timothy P. | CEO and President | Aug 06, 2020 | Sale | $105.66 | 80,000 | 8,452,716 | 225,292 | Aug 10, 2020, 06:22 PM |
| Jandrich Steven | Chief Comp Off & VP, Human Res | Jul 21, 2020 | Option Exercise | $0.94 | 1,000 | 940 | 2,805 | Jul 23, 2020, 04:17 PM |
| Jandrich Steven | Chief Comp Off & VP, Human Res | Jul 21, 2020 | Sale | $98.96 | 1,000 | 98,960 | 1,805 | Jul 23, 2020, 04:17 PM |
| Buchholz Richard | Chief Financial Officer | Jul 22, 2020 | Option Exercise | $6.26 | 42,436 | 265,755 | 73,504 | Jul 23, 2020, 04:16 PM |
| Buchholz Richard | Chief Financial Officer | Jul 21, 2020 | Option Exercise | $2.07 | 3,000 | 6,210 | 34,068 | Jul 23, 2020, 04:16 PM |
| Buchholz Richard | Chief Financial Officer | Jul 21, 2020 | Sale | $99.37 | 3,000 | 298,122 | 31,968 | Jul 23, 2020, 04:16 PM |
| Jandrich Steven | Chief Comp Off & VP, Human Res | Jun 23, 2020 | Option Exercise | $0.94 | 1,000 | 940 | 2,805 | Jun 25, 2020, 06:01 PM |
| Jandrich Steven | Chief Comp Off & VP, Human Res | Jun 23, 2020 | Sale | $96.39 | 1,000 | 96,390 | 1,805 | Jun 25, 2020, 06:01 PM |
| Buchholz Richard | Chief Financial Officer | Jun 23, 2020 | Option Exercise | $2.07 | 12,000 | 24,840 | 42,871 | Jun 25, 2020, 06:01 PM |
| Buchholz Richard | Chief Financial Officer | Jun 23, 2020 | Sale | $97.25 | 12,000 | 1,167,008 | 38,776 | Jun 25, 2020, 06:01 PM |
| NELSON MARILYN C | Director | Jun 16, 2020 | Sale | $87.94 | 10,000 | 879,409 | 178,196 | Jun 18, 2020, 09:07 PM |
| NELSON MARILYN C | Director | Jun 15, 2020 | Sale | $82.36 | 25,000 | 2,059,081 | 208,718 | Jun 18, 2020, 09:07 PM |
| Tansey Casey M | Director | Jun 15, 2020 | Sale | $84.04 | 100,000 | 8,404,255 | 124,730 | Jun 17, 2020, 04:15 PM |
| Jandrich Steven | Chief Comp Off & VP, Human Res | May 19, 2020 | Option Exercise | $0.94 | 1,000 | 940 | 2,805 | May 20, 2020, 04:15 PM |
| Jandrich Steven | Chief Comp Off & VP, Human Res | May 19, 2020 | Sale | $80.00 | 1,000 | 80,000 | 1,805 | May 20, 2020, 04:15 PM |
| Jandrich Steven | Chief Comp Off & VP, Human Res | Apr 21, 2020 | Option Exercise | $0.94 | 2,000 | 1,880 | 3,805 | Apr 23, 2020, 04:31 PM |
| Jandrich Steven | Chief Comp Off & VP, Human Res | Apr 21, 2020 | Sale | $72.68 | 2,000 | 145,360 | 1,805 | Apr 23, 2020, 04:31 PM |
| Ban Randy | Chief Commercial Officer | Apr 09, 2020 | Option Exercise | $1.14 | 10,000 | 11,400 | 10,142 | Apr 10, 2020, 05:05 PM |
| Ban Randy | Chief Commercial Officer | Apr 09, 2020 | Sale | $64.00 | 10,000 | 640,000 | 142 | Apr 10, 2020, 05:05 PM |
| Herbert Timothy P. | CEO and President | Mar 17, 2020 | Option Exercise | $0.97 | 178,786 | 174,274 | 178,786 | Mar 19, 2020, 06:07 PM |
| Khuong Chau Quang | Director | Mar 06, 2020 | Sale | $83.52 | 500,000 | 41,759,998 | 347,000 | Mar 10, 2020, 05:08 PM |
| ORBIMED ADVISORS LLC | Director | Mar 06, 2020 | Sale | $83.52 | 500,000 | 41,759,998 | 347,000 | Mar 10, 2020, 05:06 PM |
| Ban Randy | Chief Commercial Officer | Mar 04, 2020 | Option Exercise | $1.14 | 10,000 | 11,400 | 10,000 | Mar 06, 2020, 06:16 PM |
| Ban Randy | Chief Commercial Officer | Mar 04, 2020 | Sale | $86.55 | 10,000 | 865,465 | 8,199 | Mar 06, 2020, 06:16 PM |
| Khuong Chau Quang | Director | Mar 04, 2020 | Sale | $84.43 | 425,000 | 35,881,749 | 1,247,000 | Mar 05, 2020, 06:37 PM |
| Khuong Chau Quang | Director | Mar 03, 2020 | Sale | $83.21 | 75,000 | 6,240,750 | 1,272,000 | Mar 05, 2020, 06:37 PM |
| ORBIMED ADVISORS LLC | Director | Mar 03, 2020 | Sale | $84.24 | 500,000 | 42,122,499 | 1,272,000 | Mar 05, 2020, 06:34 PM |
| Tansey Casey M | Director | Feb 28, 2020 | Sale | $83.14 | 70,000 | 5,819,939 | 177,957 | Mar 03, 2020, 12:00 AM |
| Ban Randy | Chief Commercial Officer | Feb 04, 2020 | Option Exercise | $1.14 | 10,000 | 11,400 | 10,000 | Feb 06, 2020, 06:01 PM |
| Ban Randy | Chief Commercial Officer | Feb 04, 2020 | Sale | $76.21 | 10,000 | 762,075 | 3,203 | Feb 06, 2020, 06:01 PM |
| Griffin Jerry C | Director | Jan 22, 2020 | Sale | $80.93 | 1,312 | 106,180 | 28,800 | Jan 23, 2020, 04:15 PM |
| Griffin Jerry C | Director | Jan 21, 2020 | Sale | $81.92 | 5,000 | 409,587 | 31,812 | Jan 23, 2020, 04:15 PM |
| Herbert Timothy P. | CEO and President | Jan 14, 2020 | Sale | $80.00 | 15,168 | 1,213,440 | 15,324 | Jan 15, 2020, 04:52 PM |
| Herbert Timothy P. | CEO and President | Jan 13, 2020 | Sale | $80.10 | 9,832 | 787,528 | 30,567 | Jan 15, 2020, 04:52 PM |
| NELSON MARILYN C | Director | Jan 10, 2020 | Option Exercise | $80.63 | 255 | 20,561 | 2,489 | Jan 14, 2020, 04:06 PM |
| Ellis Gary Lee | Director | Jan 10, 2020 | Option Exercise | $80.63 | 170 | 13,707 | 1,170 | Jan 14, 2020, 04:06 PM |
| Jain Mudit K. | Director | Jan 10, 2020 | Option Exercise | $80.63 | 155 | 12,498 | 975 | Jan 14, 2020, 04:06 PM |
| Tansey Casey M | Director | Jan 10, 2020 | Option Exercise | $80.63 | 170 | 13,707 | 200,469 | Jan 14, 2020, 04:05 PM |
| Khuong Chau Quang | Director | Jan 10, 2020 | Option Exercise | $80.63 | 147 | 11,853 | 1,473 | Jan 14, 2020, 04:05 PM |
| Jain Mudit K. | Director | Jan 08, 2020 | Sale | $76.97 | 500 | 38,485 | 820 | Jan 08, 2020, 06:14 PM |
| Jain Mudit K. | Director | Jan 06, 2020 | Sale | $75.97 | 500 | 37,985 | 1,320 | Jan 08, 2020, 06:14 PM |
| Griffin Jerry C | Director | Jan 07, 2020 | Sale | $75.18 | 5,000 | 375,886 | 36,512 | Jan 08, 2020, 04:51 PM |
| Griffin Jerry C | Director | Jan 06, 2020 | Sale | $74.13 | 5,000 | 370,641 | 45,006 | Jan 08, 2020, 04:51 PM |
| Griffin Jerry C | Director | Dec 18, 2019 | Sale | $71.21 | 10,000 | 712,080 | 53,412 | Dec 20, 2019, 04:15 PM |
| NELSON MARILYN C | Director | Dec 06, 2019 | Sale | $75.05 | 15,000 | 1,125,750 | 211,517 | Dec 10, 2019, 04:48 PM |
| Jain Mudit K. | Director | Dec 06, 2019 | Sale | $74.97 | 500 | 37,485 | 1,820 | Dec 10, 2019, 04:48 PM |
| Jain Mudit K. | Director | Dec 04, 2019 | Sale | $74.39 | 300 | 22,317 | 2,320 | Dec 06, 2019, 04:15 PM |
| Jain Mudit K. | Director | Nov 27, 2019 | Sale | $71.97 | 300 | 21,591 | 2,620 | Dec 02, 2019, 04:16 PM |
| ORBIMED ADVISORS LLC | Director | Nov 27, 2019 | Sale | $71.63 | 53,387 | 3,823,990 | 1,398,613 | Nov 29, 2019, 11:56 AM |
| ORBIMED ADVISORS LLC | Director | Nov 26, 2019 | Sale | $69.99 | 70,613 | 4,941,926 | 1,452,191 | Nov 29, 2019, 11:56 AM |
| Khuong Chau Quang | Director | Nov 27, 2019 | Sale | $71.63 | 53,387 | 3,823,990 | 1,397,287 | Nov 29, 2019, 11:53 AM |
| Khuong Chau Quang | Director | Nov 26, 2019 | Sale | $69.99 | 70,613 | 4,941,926 | 1,450,865 | Nov 29, 2019, 11:53 AM |
| Jain Mudit K. | Director | Nov 26, 2019 | Sale | $70.04 | 3,177 | 222,506 | 4,720 | Nov 27, 2019, 04:15 PM |
| Jain Mudit K. | Director | Nov 25, 2019 | Sale | $68.47 | 500 | 34,235 | 6,097 | Nov 27, 2019, 04:15 PM |
| NELSON MARILYN C | Director | Nov 26, 2019 | Sale | $70.03 | 15,000 | 1,050,450 | 226,517 | Nov 27, 2019, 04:15 PM |
| NELSON MARILYN C | Director | Nov 25, 2019 | Sale | $68.08 | 29,000 | 1,974,320 | 241,517 | Nov 27, 2019, 04:15 PM |
| Ban Randy | Chief Commercial Officer | Nov 18, 2019 | Option Exercise | $1.47 | 6,390 | 9,393 | 7,290 | Nov 19, 2019, 04:15 PM |
| Ban Randy | Chief Commercial Officer | Nov 18, 2019 | Sale | $63.15 | 6,390 | 403,529 | 900 | Nov 19, 2019, 04:15 PM |
| Ban Randy | Chief Commercial Officer | Oct 28, 2019 | Option Exercise | $1.47 | 5,000 | 7,350 | 5,900 | Oct 29, 2019, 07:11 PM |
| Ban Randy | Chief Commercial Officer | Oct 25, 2019 | Option Exercise | $1.47 | 9,300 | 13,671 | 10,200 | Oct 29, 2019, 07:11 PM |
| Ban Randy | Chief Commercial Officer | Oct 29, 2019 | Option Exercise | $1.47 | 5,000 | 7,350 | 5,900 | Oct 29, 2019, 07:11 PM |
| Ban Randy | Chief Commercial Officer | Oct 25, 2019 | Sale | $58.01 | 9,300 | 539,493 | 900 | Oct 29, 2019, 07:11 PM |
| Ban Randy | Chief Commercial Officer | Oct 29, 2019 | Sale | $59.92 | 5,000 | 299,621 | 3,902 | Oct 29, 2019, 07:11 PM |
| Ban Randy | Chief Commercial Officer | Oct 28, 2019 | Sale | $58.43 | 5,000 | 292,150 | 900 | Oct 29, 2019, 07:11 PM |
| Herbert Timothy P. | CEO and President | Oct 22, 2019 | Sale | $55.78 | 25,000 | 1,394,454 | 68,566 | Oct 24, 2019, 06:41 PM |
| Tansey Casey M | Director | Oct 10, 2019 | Option Exercise | $54.84 | 250 | 13,710 | 200,299 | Oct 15, 2019, 04:25 PM |
| NELSON MARILYN C | Director | Oct 10, 2019 | Option Exercise | $54.84 | 376 | 20,620 | 2,234 | Oct 15, 2019, 04:23 PM |
| Khuong Chau Quang | Director | Oct 10, 2019 | Option Exercise | $54.84 | 216 | 11,845 | 1,326 | Oct 15, 2019, 04:19 PM |
| Jain Mudit K. | Director | Oct 10, 2019 | Option Exercise | $54.84 | 227 | 12,449 | 6,597 | Oct 15, 2019, 04:17 PM |
| Ban Randy | Chief Commercial Officer | Oct 07, 2019 | Option Exercise | $1.47 | 700 | 1,029 | 1,600 | Oct 08, 2019, 06:31 PM |
| Ban Randy | Chief Commercial Officer | Oct 07, 2019 | Sale | $58.30 | 700 | 40,810 | 900 | Oct 08, 2019, 06:31 PM |
| Buchholz Richard | Chief Financial Officer | Sep 30, 2019 | Option Exercise | $1.55 | 28,000 | 43,270 | 30,706 | Oct 02, 2019, 07:16 PM |
| Buchholz Richard | Chief Financial Officer | Sep 30, 2019 | Option Exercise | $1.55 | 28,000 | 43,270 | 30,706 | Oct 02, 2019, 04:33 PM |
| Herbert Timothy P. | CEO and President | Sep 24, 2019 | Sale | $66.14 | 5,000 | 330,714 | 78,162 | Sep 26, 2019, 04:32 PM |
| NELSON MARILYN C | Director | Sep 20, 2019 | Sale | $67.09 | 30,000 | 2,012,700 | 270,517 | Sep 24, 2019, 04:36 PM |
| Ban Randy | Chief Commercial Officer | Sep 12, 2019 | Option Exercise | $1.47 | 10,000 | 14,700 | 10,900 | Sep 16, 2019, 04:48 PM |
| Ban Randy | Chief Commercial Officer | Sep 12, 2019 | Sale | $61.62 | 10,000 | 616,181 | 3,982 | Sep 16, 2019, 04:48 PM |
| NELSON MARILYN C | Director | Sep 09, 2019 | Sale | $66.71 | 60,000 | 4,002,580 | 326,717 | Sep 11, 2019, 04:15 PM |
| Herbert Timothy P. | CEO and President | Sep 06, 2019 | Sale | $70.00 | 10,000 | 700,000 | 79,624 | Sep 10, 2019, 04:22 PM |
| Herbert Timothy P. | CEO and President | Sep 03, 2019 | Sale | $67.19 | 10,000 | 671,885 | 94,125 | Sep 05, 2019, 04:16 PM |
| Herbert Timothy P. | CEO and President | Aug 27, 2019 | Sale | $65.96 | 15,000 | 989,340 | 105,142 | Aug 28, 2019, 04:15 PM |
| Jain Mudit K. | Director | Aug 21, 2019 | Sale | $69.00 | 980 | 67,620 | 6,370 | Aug 22, 2019, 04:15 PM |
| Jain Mudit K. | Director | Aug 20, 2019 | Sale | $68.51 | 270 | 18,498 | 7,350 | Aug 22, 2019, 04:15 PM |
| Jain Mudit K. | Director | Aug 16, 2019 | Sale | $65.51 | 490 | 32,102 | 9,476 | Aug 20, 2019, 04:28 PM |
| Jain Mudit K. | Director | Aug 19, 2019 | Sale | $67.21 | 1,750 | 117,620 | 8,370 | Aug 20, 2019, 04:28 PM |
| Buchholz Richard | Chief Financial Officer | Aug 19, 2019 | Option Exercise | $2.07 | 4,000 | 8,280 | 6,706 | Aug 20, 2019, 04:28 PM |
| Buchholz Richard | Chief Financial Officer | Aug 19, 2019 | Sale | $66.86 | 4,000 | 267,426 | 4,806 | Aug 20, 2019, 04:28 PM |
| Herbert Timothy P. | CEO and President | Aug 01, 2019 | Sale | $68.02 | 10,000 | 680,151 | 121,672 | Aug 05, 2019, 04:15 PM |
| Herbert Timothy P. | CEO and President | Jul 23, 2019 | Sale | $66.95 | 15,000 | 1,004,288 | 124,724 | Jul 24, 2019, 04:54 PM |
| Erony Joyce | Director | Jul 18, 2019 | Sale | $67.97 | 39,750 | 2,701,835 | 103,939 | Jul 18, 2019, 08:41 PM |
| Erony Joyce | Director | Jul 17, 2019 | Sale | $68.28 | 53,964 | 3,684,721 | 143,689 | Jul 18, 2019, 08:41 PM |
| Erony Joyce | Director | Jul 16, 2019 | Sale | $68.27 | 22,738 | 1,552,291 | 197,653 | Jul 18, 2019, 08:41 PM |
| Tansey Casey M | Director | Jul 15, 2019 | Option Exercise | $68.88 | 199 | 13,707 | 200,049 | Jul 17, 2019, 04:57 PM |
| Khuong Chau Quang | Director | Jul 15, 2019 | Option Exercise | $68.88 | 172 | 11,847 | 1,110 | Jul 17, 2019, 04:52 PM |
| Jain Mudit K. | Director | Jul 15, 2019 | Option Exercise | $68.88 | 181 | 12,467 | 14,660 | Jul 17, 2019, 04:51 PM |
| Jain Mudit K. | Director | Jul 15, 2019 | Sale | $66.72 | 4,800 | 320,257 | 11,160 | Jul 17, 2019, 04:51 PM |
| NELSON MARILYN C | Director | Jul 15, 2019 | Option Exercise | $68.88 | 296 | 20,388 | 1,858 | Jul 17, 2019, 04:51 PM |
| Buchholz Richard | Chief Financial Officer | Jul 16, 2019 | Option Exercise | $2.07 | 4,000 | 8,280 | 6,706 | Jul 17, 2019, 04:49 PM |
| Buchholz Richard | Chief Financial Officer | Jul 16, 2019 | Sale | $68.34 | 4,000 | 273,360 | 2,706 | Jul 17, 2019, 04:49 PM |
| Erony Joyce | Director | Jul 12, 2019 | Sale | $66.63 | 41,075 | 2,736,905 | 273,257 | Jul 15, 2019, 08:17 PM |
| Erony Joyce | Director | Jul 11, 2019 | Sale | $66.79 | 31,519 | 2,105,163 | 314,332 | Jul 15, 2019, 08:17 PM |
| Erony Joyce | Director | Jul 15, 2019 | Sale | $68.60 | 52,866 | 3,626,439 | 220,391 | Jul 15, 2019, 08:17 PM |
| Erony Joyce | Director | Jul 10, 2019 | Sale | $66.70 | 54,715 | 3,649,430 | 345,851 | Jul 10, 2019, 08:04 PM |
| Erony Joyce | Director | Jul 09, 2019 | Sale | $65.77 | 38,122 | 2,507,444 | 400,566 | Jul 10, 2019, 08:04 PM |
| Erony Joyce | Director | Jul 08, 2019 | Sale | $67.60 | 98,355 | 6,648,336 | 438,688 | Jul 10, 2019, 08:04 PM |
| Herbert Timothy P. | CEO and President | Jul 03, 2019 | Sale | $65.00 | 10,000 | 650,000 | 139,624 | Jul 08, 2019, 04:27 PM |
| NELSON MARILYN C | Director | Jul 08, 2019 | Sale | $66.59 | 18,898 | 1,258,339 | 366,215 | Jul 08, 2019, 04:25 PM |
| NELSON MARILYN C | Director | Jul 03, 2019 | Sale | $65.01 | 6,102 | 396,691 | 379,415 | Jul 08, 2019, 04:25 PM |
| Herbert Timothy P. | CEO and President | Jun 25, 2019 | Sale | $58.71 | 25,000 | 1,467,738 | 155,852 | Jun 26, 2019, 04:16 PM |
| Buchholz Richard | Chief Financial Officer | Jun 17, 2019 | Option Exercise | $2.07 | 4,000 | 8,280 | 6,350 | Jun 18, 2019, 04:09 PM |
| Buchholz Richard | Chief Financial Officer | Jun 17, 2019 | Sale | $56.37 | 4,000 | 225,498 | 5,860 | Jun 18, 2019, 04:09 PM |
| Ban Randy | Senior VP, Sales and Marketing | Jun 04, 2019 | Sale | $53.99 | 3,000 | 161,956 | 1,651 | Jun 05, 2019, 04:25 PM |
| Ban Randy | Senior VP, Sales and Marketing | Jun 03, 2019 | Sale | $55.99 | 7,000 | 391,908 | 7,420 | Jun 05, 2019, 04:25 PM |
| Erony Joyce | Director | May 31, 2019 | Sale | $56.05 | 34,495 | 1,933,359 | 537,043 | Jun 04, 2019, 08:34 AM |
| Erony Joyce | Director | May 30, 2019 | Sale | $55.43 | 32,073 | 1,777,928 | 571,538 | Jun 04, 2019, 08:34 AM |
| Erony Joyce | Director | May 29, 2019 | Sale | $54.39 | 20,449 | 1,112,129 | 603,611 | May 29, 2019, 09:53 PM |
| Erony Joyce | Director | May 28, 2019 | Sale | $54.12 | 600 | 32,470 | 624,060 | May 29, 2019, 09:53 PM |
| Erony Joyce | Director | May 24, 2019 | Sale | $54.17 | 23,004 | 1,246,226 | 624,660 | May 29, 2019, 09:53 PM |
| Herbert Timothy P. | CEO and President | May 28, 2019 | Sale | $52.55 | 25,000 | 1,313,812 | 179,458 | May 29, 2019, 05:24 PM |
| Erony Joyce | Director | May 23, 2019 | Sale | $54.00 | 137 | 7,398 | 647,664 | May 23, 2019, 09:57 PM |
| Erony Joyce | Director | May 22, 2019 | Sale | $54.38 | 26,388 | 1,434,948 | 647,801 | May 23, 2019, 09:57 PM |
| Erony Joyce | Director | May 21, 2019 | Sale | $54.82 | 12,854 | 704,606 | 674,189 | May 23, 2019, 09:57 PM |
| Buchholz Richard | Chief Financial Officer | May 20, 2019 | Option Exercise | $2.07 | 4,000 | 8,280 | 6,350 | May 21, 2019, 05:06 PM |
| Buchholz Richard | Chief Financial Officer | May 20, 2019 | Sale | $50.05 | 4,000 | 200,200 | 2,350 | May 21, 2019, 05:06 PM |
| Ban Randy | Senior VP, Sales and Marketing | May 02, 2019 | Sale | $50.03 | 1,637 | 81,899 | 14,300 | May 03, 2019, 04:52 PM |
| Ban Randy | Senior VP, Sales and Marketing | May 01, 2019 | Sale | $50.16 | 5,037 | 252,656 | 15,937 | May 03, 2019, 04:52 PM |
| Ban Randy | Senior VP, Sales and Marketing | May 03, 2019 | Sale | $50.01 | 3,400 | 170,034 | 10,900 | May 03, 2019, 04:52 PM |
| Herbert Timothy P. | CEO and President | Apr 22, 2019 | Option Exercise | $1.55 | 282,875 | 438,207 | 282,875 | Apr 24, 2019, 05:11 PM |
| Herbert Timothy P. | CEO and President | Apr 16, 2019 | Sale | $54.97 | 15,000 | 824,538 | 207,081 | Apr 18, 2019, 05:13 PM |
| Buchholz Richard | Chief Financial Officer | Apr 16, 2019 | Option Exercise | $2.07 | 4,000 | 8,280 | 8,750 | Apr 18, 2019, 05:13 PM |
| Buchholz Richard | Chief Financial Officer | Apr 16, 2019 | Sale | $56.05 | 4,000 | 224,204 | 6,776 | Apr 18, 2019, 05:13 PM |
| Tansey Casey M | Director | Apr 10, 2019 | Option Exercise | $55.63 | 247 | 13,741 | 199,850 | Apr 12, 2019, 04:29 PM |
| Khuong Chau Quang | Director | Apr 10, 2019 | Option Exercise | $55.63 | 213 | 11,849 | 938 | Apr 12, 2019, 04:29 PM |
| Jain Mudit K. | Director | Apr 10, 2019 | Option Exercise | $55.63 | 224 | 12,461 | 987 | Apr 12, 2019, 04:29 PM |
| NELSON MARILYN C | Director | Apr 10, 2019 | Option Exercise | $55.63 | 359 | 19,971 | 1,562 | Apr 12, 2019, 04:28 PM |
| NELSON MARILYN C | Director | Apr 10, 2019 | Sale | $55.21 | 47,015 | 2,595,698 | 426,151 | Apr 12, 2019, 04:28 PM |
| Ban Randy | Senior VP, Sales and Marketing | Apr 05, 2019 | Sale | $51.70 | 10,000 | 517,030 | 22,374 | Apr 08, 2019, 04:16 PM |
| NELSON MARILYN C | Director | Apr 01, 2019 | Sale | $52.62 | 89,554 | 4,712,495 | 576,409 | Apr 03, 2019, 05:43 PM |
| NELSON MARILYN C | Director | Apr 02, 2019 | Sale | $50.29 | 63,431 | 3,189,967 | 494,563 | Apr 03, 2019, 05:43 PM |
| Ban Randy | Sr VP, Sales & Marketing | Apr 02, 2019 | Sale | $50.28 | 5,000 | 251,382 | 22,389 | Apr 03, 2019, 05:42 PM |
| Ban Randy | Sr VP, Sales & Marketing | Apr 01, 2019 | Sale | $52.75 | 5,000 | 263,736 | 30,774 | Apr 03, 2019, 05:42 PM |
| Buchholz Richard | Chief Financial Officer | Mar 20, 2019 | Option Exercise | $2.07 | 2,000 | 4,140 | 6,750 | Mar 22, 2019, 04:16 PM |
| Buchholz Richard | Chief Financial Officer | Mar 20, 2019 | Sale | $56.25 | 2,000 | 112,500 | 4,750 | Mar 22, 2019, 04:16 PM |
| Herbert Timothy P. | CEO and President | Mar 19, 2019 | Sale | $56.47 | 15,000 | 847,042 | 217,571 | Mar 21, 2019, 06:08 PM |
| ORBIMED ADVISORS LLC | Director | Mar 07, 2019 | Sale | $55.01 | 68,218 | 3,752,672 | 1,761,956 | Mar 11, 2019, 09:30 PM |
| ORBIMED ADVISORS LLC | Director | Mar 08, 2019 | Sale | $57.75 | 290,231 | 16,760,840 | 1,471,725 | Mar 11, 2019, 09:30 PM |
| Khuong Chau Quang | Director | Mar 08, 2019 | Sale | $57.75 | 290,231 | 16,760,840 | 1,471,000 | Mar 11, 2019, 09:25 PM |
| Khuong Chau Quang | Director | Mar 07, 2019 | Sale | $55.01 | 68,218 | 3,752,672 | 1,761,231 | Mar 11, 2019, 09:25 PM |
| Tansey Casey M | Director | Mar 07, 2019 | Sale | $54.78 | 25,000 | 1,369,395 | 199,603 | Mar 07, 2019, 09:12 PM |
| Buchholz Richard | Chief Financial Officer | Feb 20, 2019 | Option Exercise | $2.07 | 2,000 | 4,140 | 6,750 | Feb 22, 2019, 04:15 PM |
| Buchholz Richard | Chief Financial Officer | Feb 20, 2019 | Sale | $56.87 | 2,000 | 113,740 | 4,750 | Feb 22, 2019, 04:15 PM |
| Herbert Timothy P. | CEO and President | Feb 19, 2019 | Sale | $57.34 | 15,000 | 860,100 | 229,624 | Feb 21, 2019, 06:41 PM |
| Erony Joyce | Director | Feb 05, 2019 | Sale | $53.92 | 37,946 | 2,046,136 | 687,043 | Feb 07, 2019, 04:04 PM |
| Erony Joyce | Director | Feb 04, 2019 | Sale | $52.63 | 16,708 | 879,260 | 724,989 | Feb 04, 2019, 07:25 PM |
| Erony Joyce | Director | Feb 01, 2019 | Sale | $52.94 | 15,311 | 810,520 | 741,697 | Feb 04, 2019, 07:25 PM |
| Erony Joyce | Director | Jan 31, 2019 | Sale | $53.54 | 20,035 | 1,072,716 | 757,008 | Feb 04, 2019, 07:25 PM |
| Erony Joyce | Director | Jan 28, 2019 | Sale | $53.65 | 34,752 | 1,864,330 | 809,312 | Jan 30, 2019, 05:32 PM |
| Erony Joyce | Director | Jan 30, 2019 | Sale | $52.56 | 13,149 | 691,075 | 777,043 | Jan 30, 2019, 05:32 PM |
| Erony Joyce | Director | Jan 29, 2019 | Sale | $52.49 | 19,120 | 1,003,636 | 790,192 | Jan 30, 2019, 05:32 PM |
| Erony Joyce | Director | Jan 25, 2019 | Sale | $53.09 | 21,379 | 1,135,015 | 844,064 | Jan 25, 2019, 06:18 PM |
| Erony Joyce | Director | Jan 24, 2019 | Sale | $52.37 | 28,718 | 1,503,984 | 867,043 | Jan 25, 2019, 06:18 PM |
| Erony Joyce | Director | Jan 23, 2019 | Sale | $52.40 | 12,773 | 669,318 | 894,161 | Jan 25, 2019, 06:18 PM |
| Buchholz Richard | Chief Financial Officer | Jan 22, 2019 | Option Exercise | $2.07 | 6,000 | 12,420 | 10,750 | Jan 23, 2019, 04:16 PM |
| Buchholz Richard | Chief Financial Officer | Jan 22, 2019 | Sale | $54.18 | 6,000 | 325,080 | 4,750 | Jan 23, 2019, 04:16 PM |
| Erony Joyce | Director | Jan 22, 2019 | Sale | $54.00 | 20,905 | 1,128,791 | 906,934 | Jan 23, 2019, 10:38 AM |
| Erony Joyce | Director | Jan 18, 2019 | Sale | $54.93 | 64,820 | 3,560,253 | 957,043 | Jan 23, 2019, 10:38 AM |
| Erony Joyce | Director | Jan 17, 2019 | Sale | $53.57 | 203,680 | 10,911,170 | 1,137,043 | Jan 23, 2019, 10:38 AM |
| Erony Joyce | Director | Jan 15, 2019 | Sale | $48.89 | 114,568 | 5,601,527 | 1,407,043 | Jan 23, 2019, 10:36 AM |
| Erony Joyce | Director | Jan 14, 2019 | Sale | $48.69 | 88,000 | 4,284,421 | 1,409,043 | Jan 23, 2019, 10:36 AM |
| Erony Joyce | Director | Jan 16, 2019 | Sale | $50.35 | 98,136 | 4,941,155 | 1,263,771 | Jan 23, 2019, 10:36 AM |
| Erony Joyce | Director | Jan 18, 2018 | Sale | $54.93 | 64,820 | 3,560,253 | 957,043 | Jan 22, 2019, 06:31 PM |
| Erony Joyce | Director | Jan 17, 2018 | Sale | $53.57 | 203,680 | 10,911,170 | 1,137,043 | Jan 22, 2019, 06:31 PM |
| Erony Joyce | Director | Jan 22, 2018 | Sale | $54.00 | 20,905 | 1,128,791 | 906,934 | Jan 22, 2019, 06:31 PM |
| Herbert Timothy P. | CEO and President | Jan 15, 2019 | Sale | $48.70 | 15,000 | 730,430 | 255,824 | Jan 17, 2019, 04:49 PM |
| Erony Joyce | Director | Jan 16, 2018 | Sale | $50.35 | 98,136 | 4,941,155 | 1,263,771 | Jan 16, 2019, 06:49 PM |
| Erony Joyce | Director | Jan 15, 2018 | Sale | $48.89 | 114,568 | 5,601,527 | 1,407,043 | Jan 16, 2019, 06:49 PM |
| Erony Joyce | Director | Jan 14, 2018 | Sale | $48.69 | 88,000 | 4,284,421 | 1,409,043 | Jan 16, 2019, 06:49 PM |
| Ban Randy | Senior VP, Sales and Marketing | Jan 15, 2019 | Option Exercise | $1.47 | 5,000 | 7,350 | 35,974 | Jan 16, 2019, 04:41 PM |
| Ban Randy | Senior VP, Sales and Marketing | Jan 14, 2019 | Option Exercise | $1.47 | 5,000 | 7,350 | 35,974 | Jan 16, 2019, 04:41 PM |
| Ban Randy | Senior VP, Sales and Marketing | Jan 15, 2019 | Sale | $48.77 | 5,000 | 243,830 | 33,029 | Jan 16, 2019, 04:41 PM |
| Ban Randy | Senior VP, Sales and Marketing | Jan 14, 2019 | Sale | $48.42 | 5,000 | 242,109 | 35,374 | Jan 16, 2019, 04:41 PM |
| Tansey Casey M | Director | Jan 10, 2019 | Option Exercise | $46.58 | 295 | 13,741 | 201,680 | Jan 14, 2019, 04:32 PM |
| NELSON MARILYN C | Director | Jan 10, 2019 | Option Exercise | $46.58 | 429 | 19,983 | 1,203 | Jan 14, 2019, 04:31 PM |
| Jain Mudit K. | Director | Jan 10, 2019 | Option Exercise | $46.58 | 268 | 12,483 | 763 | Jan 14, 2019, 04:31 PM |
| Khuong Chau Quang | Director | Jan 10, 2019 | Option Exercise | $46.58 | 254 | 11,831 | 725 | Jan 14, 2019, 04:30 PM |
| Herbert Timothy P. | CEO and President | Dec 18, 2018 | Sale | $42.88 | 15,000 | 643,213 | 267,924 | Dec 19, 2018, 04:15 PM |
| Griffin Jerry C | Director | Dec 11, 2018 | Sale | $37.60 | 1,300 | 48,880 | 55,112 | Dec 13, 2018, 06:13 PM |
| Khuong Chau Quang | Director | Dec 11, 2018 | Sale | $37.60 | 614,772 | 23,115,426 | 1,829,449 | Dec 13, 2018, 04:38 PM |
| ORBIMED ADVISORS LLC | Director | Dec 11, 2018 | Sale | $37.60 | 614,772 | 23,115,426 | 1,829,449 | Dec 13, 2018, 04:35 PM |
| Ban Randy | Senior VP, Sales and Marketing | Nov 19, 2018 | Option Exercise | $1.47 | 10,000 | 14,700 | 40,974 | Nov 21, 2018, 04:16 PM |
| Ban Randy | Senior VP, Sales and Marketing | Nov 19, 2018 | Sale | $40.79 | 5,000 | 203,969 | 38,818 | Nov 21, 2018, 04:16 PM |
| Ban Randy | Senior VP, Sales and Marketing | Nov 20, 2018 | Sale | $39.95 | 5,000 | 199,770 | 32,706 | Nov 21, 2018, 04:16 PM |
| Herbert Timothy P. | CEO and President | Nov 20, 2018 | Sale | $39.89 | 15,000 | 598,382 | 279,489 | Nov 21, 2018, 04:15 PM |
| NELSON MARILYN C | Director | Oct 10, 2018 | Option Exercise | $40.60 | 492 | 19,975 | 774 | Oct 12, 2018, 11:49 AM |
| Tansey Casey M | Director | Oct 10, 2018 | Option Exercise | $40.60 | 338 | 13,723 | 188,045 | Oct 12, 2018, 11:48 AM |
| Jain Mudit K. | Director | Oct 10, 2018 | Option Exercise | $40.60 | 307 | 12,464 | 495 | Oct 12, 2018, 11:47 AM |
| Khuong Chau Quang | Director | Oct 10, 2018 | Option Exercise | $40.60 | 292 | 11,855 | 471 | Oct 12, 2018, 11:47 AM |
| Tansey Casey M | Director | Jul 12, 2018 | Option Exercise | $43.00 | 207 | 8,901 | 187,707 | Jul 16, 2018, 04:21 PM |
| Jain Mudit K. | Director | Jul 12, 2018 | Option Exercise | $43.00 | 188 | 8,084 | 188 | Jul 16, 2018, 04:20 PM |
| Khuong Chau Quang | Director | Jul 12, 2018 | Option Exercise | $43.00 | 179 | 7,697 | 179 | Jul 16, 2018, 04:19 PM |
| NELSON MARILYN C | Director | Jul 12, 2018 | Option Exercise | $43.00 | 282 | 12,126 | 282 | Jul 16, 2018, 04:18 PM |
| NELSON MARILYN C | Director | May 07, 2018 | Buy | $16.00 | 62,500 | 1,000,000 | 631,451 | May 09, 2018, 09:46 PM |
| Khuong Chau Quang | Director | May 07, 2018 | Buy | $16.00 | 312,500 | 5,000,000 | 2,444,221 | May 09, 2018, 09:22 PM |
| ORBIMED ADVISORS LLC | 10% Owner | May 07, 2018 | Buy | $16.00 | 312,500 | 5,000,000 | 2,444,221 | May 09, 2018, 09:21 PM |
| McCormick Shawn | Director | May 07, 2018 | Buy | $16.00 | 3,000 | 48,000 | 3,000 | May 09, 2018, 09:19 PM |
| Amzak Health Investors, LLC | 10% Owner | May 07, 2018 | Buy | $16.00 | 125,000 | 2,000,000 | 1,497,043 | May 09, 2018, 09:19 PM |
| Tansey Casey M | Director | May 07, 2018 | Buy | $16.00 | 187,500 | 3,000,000 | 187,500 | May 09, 2018, 09:19 PM |
| Mead Dana G Jr. | Director | May 07, 2018 | Buy | $16.00 | 20,000 | 320,000 | 20,000 | May 09, 2018, 09:16 PM |
| Erony Joyce | Director | May 07, 2018 | Buy | $16.00 | 125,000 | 2,000,000 | 1,497,043 | May 09, 2018, 09:16 PM |
| Herbert Timothy P. | CEO and President | May 07, 2018 | Buy | $16.00 | 350 | 5,600 | 350 | May 09, 2018, 08:41 PM |
| Jandrich Steven | Chief Comp Off & VP, Human Res | May 07, 2018 | Buy | $16.00 | 350 | 5,600 | 350 | May 09, 2018, 08:41 PM |
| Jandrich Steven | Chief Comp Off & VP, Human Res | May 07, 2018 | Buy | $16.00 | 350 | 5,600 | 350 | May 09, 2018, 08:41 PM |
| Jandrich Steven | Chief Comp Off & VP, Human Res | May 07, 2018 | Buy | $16.00 | 1,350 | 21,600 | 1,350 | May 09, 2018, 08:41 PM |
| Buchholz Richard | Chief Financial Officer | May 07, 2018 | Buy | $16.00 | 4,750 | 76,000 | 4,750 | May 09, 2018, 08:40 PM |
| Ban Randy | Senior VP, Sales and Marketing | May 07, 2018 | Buy | $16.00 | 900 | 14,400 | 30,974 | May 09, 2018, 08:40 PM |
Load More Insider Transactions
Buy
Sale
Option Exercise
| Owner | Relationship | Date | Value($) |
| McCormick Shawn | Director | 09/09/2024 | 176,000 |
| Rondoni John | Chief Technology Officer | 09/09/2024 | 6,665 |
| Rondoni John | Chief Technology Officer | 08/22/2024 | 355,000 |
| Rondoni John | Chief Technology Officer | 08/22/2024 | 949,143 |
| Ban Randy | Chief Commercial Officer | 08/16/2024 | 204,891 |
| Ban Randy | Chief Commercial Officer | 08/15/2024 | 680,259 |
| Ban Randy | Chief Commercial Officer | 08/15/2024 | 3,116,397 |
| Ban Randy | Chief Commercial Officer | 08/16/2024 | 916,549 |
| McCormick Shawn | Director | 08/14/2024 | 8,025 |
| Tansey Casey M | Director | 07/15/2024 | 14,274 |
| Melenikiotou Georgia | Director | 07/15/2024 | 4,435 |
| Ellis Gary Lee | Director | 07/15/2024 | 21,341 |
| Broader Shelley G. | Director | 07/15/2024 | 16,214 |
| McCormick Shawn | Director | 05/10/2024 | 2,350 |
| NELSON MARILYN C | Director | 04/29/2024 | 282,799 |
| Buchholz Richard | Chief Financial Officer | 04/17/2024 | 3,450,450 |
| Ellis Gary Lee | Director | 04/12/2024 | 16,222 |
| Tansey Casey M | Director | 04/12/2024 | 14,368 |
| Broader Shelley G. | Director | 04/12/2024 | 16,222 |
| Melenikiotou Georgia | Director | 04/12/2024 | 12,977 |
| NELSON MARILYN C | Director | 04/12/2024 | 24,796 |
| Herbert Timothy P. | CEO and President | 04/01/2024 | 8,203,581 |
| Herbert Timothy P. | CEO and President | 04/01/2024 | 8,203,581 |
| Griffin Jerry C | Director | 04/01/2024 | 4,736 |
| Griffin Jerry C | Director | 04/01/2024 | 6,848 |
| NELSON MARILYN C | Director | 04/01/2024 | 52,368 |
| NELSON MARILYN C | Director | 03/27/2024 | 294,633 |
| Griffin Jerry C | Director | 03/25/2024 | 16,000 |
| Griffin Jerry C | Director | 03/25/2024 | 109,587 |
| Rondoni John | Chief Technology Officer | 03/22/2024 | 852,849 |
| Griffin Jerry C | Director | 03/18/2024 | 16,000 |
| Griffin Jerry C | Director | 03/18/2024 | 107,216 |
| Griffin Jerry C | Director | 03/11/2024 | 16,000 |
| Griffin Jerry C | Director | 03/11/2024 | 109,720 |
| Griffin Jerry C | Director | 03/01/2024 | 16,000 |
| Griffin Jerry C | Director | 03/01/2024 | 99,410 |
| NELSON MARILYN C | Director | 03/01/2024 | 2,402 |
| Rondoni John | Chief Technology Officer | 02/29/2024 | 1,542,441 |
| Ban Randy | Chief Commercial Officer | 02/27/2024 | 128,979 |
| Ban Randy | Chief Commercial Officer | 02/23/2024 | 50,234 |
| Ban Randy | Chief Commercial Officer | 02/27/2024 | 556,951 |
| Ban Randy | Chief Commercial Officer | 02/23/2024 | 2,267,075 |
| Rondoni John | Chief Technology Officer | 02/15/2024 | 16,560 |
| NELSON MARILYN C | Director | 02/09/2024 | 3,760 |
| Phillips Bryan K | See Remarks | 01/29/2024 | 44,405 |
| Jandrich Steven | VP, Human Resources | 01/30/2024 | 15,251 |
| Sparks Charisse Y | Chief Medical Officer | 10/12/2023 | 15,350 |
| Melenikiotou Georgia | Director | 01/16/2024 | 16,744 |
| NELSON MARILYN C | Director | 01/16/2024 | 31,306 |
| Ellis Gary Lee | Director | 01/16/2024 | 18,046 |
| Broader Shelley G. | Director | 01/16/2024 | 18,046 |
| Sparks Charisse Y | Chief Medical Officer | 01/16/2024 | 1,103 |
| Tansey Casey M | Director | 01/16/2024 | 16,185 |
| NELSON MARILYN C | Director | 10/13/2023 | 21,216 |
| NELSON MARILYN C | Director | 10/17/2023 | 1,880 |
| Sparks Charisse Y | Director | 10/13/2023 | 3,762 |
| Broader Shelley G. | Director | 10/13/2023 | 14,897 |
| Tansey Casey M | Director | 10/13/2023 | 13,091 |
| Melenikiotou Georgia | Director | 10/13/2023 | 13,693 |
| Ellis Gary Lee | Director | 10/13/2023 | 14,897 |
| Herbert Timothy P. | CEO and President | 10/12/2023 | 13,014,741 |
| Herbert Timothy P. | CEO and President | 10/12/2023 | 1,590,893 |
| Herbert Timothy P. | CEO and President | 10/12/2023 | 225,890 |
| Herbert Timothy P. | CEO and President | 10/12/2023 | 902,922 |
| NELSON MARILYN C | Director | 09/21/2023 | 1,880 |
| NELSON MARILYN C | Director | 09/14/2023 | 1,880 |
| Jandrich Steven | VP, Human Resources | 08/28/2023 | 2,350 |
| Herbert Timothy P. | CEO and President | 08/23/2023 | 67,230 |
| NELSON MARILYN C | Director | 08/21/2023 | 1,880 |
| NELSON MARILYN C | Director | 08/10/2023 | 1,880 |
| NELSON MARILYN C | Director | 08/07/2023 | 1,880 |
| NELSON MARILYN C | Director | 08/04/2023 | 1,880 |
| Griffin Jerry C | Director | 07/31/2023 | 16,000 |
| Griffin Jerry C | Director | 07/31/2023 | 153,659 |
| NELSON MARILYN C | Director | 07/24/2023 | 1,880 |
| Griffin Jerry C | Director | 07/24/2023 | 16,000 |
| Griffin Jerry C | Director | 07/24/2023 | 161,340 |
| Tansey Casey M | Director | 07/17/2023 | 13,036 |
| NELSON MARILYN C | Director | 07/17/2023 | 21,184 |
| Griffin Jerry C | Director | 07/17/2023 | 16,000 |
| Griffin Jerry C | Director | 07/17/2023 | 172,898 |
| Melenikiotou Georgia | Director | 07/17/2023 | 13,688 |
| Ellis Gary Lee | Director | 07/17/2023 | 14,992 |
| Broader Shelley G. | Director | 07/17/2023 | 14,992 |
| Sparks Charisse Y | Director | 07/17/2023 | 13,036 |
| Griffin Jerry C | Director | 07/10/2023 | 16,000 |
| Griffin Jerry C | Director | 07/10/2023 | 164,212 |
| Griffin Jerry C | Director | 07/03/2023 | 16,000 |
| Griffin Jerry C | Director | 07/03/2023 | 170,386 |
| Griffin Jerry C | Director | 06/26/2023 | 16,000 |
| Griffin Jerry C | Director | 06/26/2023 | 167,095 |
| Griffin Jerry C | Director | 06/20/2023 | 16,000 |
| Griffin Jerry C | Director | 06/20/2023 | 162,742 |
| Griffin Jerry C | Director | 06/12/2023 | 16,000 |
| Griffin Jerry C | Director | 06/12/2023 | 163,477 |
| Griffin Jerry C | Director | 06/05/2023 | 16,000 |
| Griffin Jerry C | Director | 06/05/2023 | 161,710 |
| Griffin Jerry C | Director | 05/30/2023 | 16,000 |
| Griffin Jerry C | Director | 05/30/2023 | 156,002 |
| Griffin Jerry C | Director | 05/22/2023 | 16,000 |
| Griffin Jerry C | Director | 05/22/2023 | 162,678 |
| Griffin Jerry C | Director | 05/15/2023 | 16,000 |
| Griffin Jerry C | Director | 05/15/2023 | 155,478 |
| Jandrich Steven | VP, Human Resources | 05/12/2023 | 321,275 |
| Jandrich Steven | VP, Human Resources | 05/12/2023 | 1,325,107 |
| Jandrich Steven | VP, Human Resources | 05/08/2023 | 72,793 |
| Jandrich Steven | VP, Human Resources | 05/08/2023 | 483,767 |
| Griffin Jerry C | Director | 05/08/2023 | 16,000 |
| Griffin Jerry C | Director | 05/08/2023 | 148,120 |
| Jandrich Steven | VP, Human Resources | 04/25/2023 | 337,200 |
| Jandrich Steven | VP, Human Resources | 04/25/2023 | 2,168,164 |
| Tansey Casey M | Director | 04/10/2023 | 12,979 |
| Sparks Charisse Y | Director | 04/10/2023 | 12,979 |
| Melenikiotou Georgia | Director | 04/10/2023 | 13,674 |
| NELSON MARILYN C | Director | 04/10/2023 | 21,091 |
| Broader Shelley G. | Director | 04/10/2023 | 14,833 |
| Ellis Gary Lee | Director | 04/10/2023 | 14,833 |
| McCormick Shawn | Director | 03/17/2023 | 3,760 |
| Herbert Timothy P. | CEO and President | 03/29/2022 | 2,023,411 |
| Herbert Timothy P. | CEO and President | 03/29/2022 | 3,788,249 |
| Herbert Timothy P. | CEO and President | 03/29/2022 | 18,593,613 |
| Herbert Timothy P. | CEO and President | 03/17/2022 | 4,230,073 |
| Herbert Timothy P. | CEO and President | 03/17/2022 | 277,964 |
| Herbert Timothy P. | CEO and President | 02/15/2023 | 3,223,617 |
| Herbert Timothy P. | CEO and President | 02/14/2023 | 5,548,477 |
| Rondoni John | Chief Technology Officer | 03/08/2023 | 9,081 |
| Ebeling Philip | Chief Operating Officer | 02/16/2023 | 1,363,740 |
| Ebeling Philip | Chief Operating Officer | 02/16/2023 | 1,925,000 |
| Herbert Timothy P. | CEO and President | 02/13/2023 | 720,356 |
| Herbert Timothy P. | CEO and President | 02/09/2023 | 1,933,543 |
| Herbert Timothy P. | CEO and President | 02/08/2023 | 962,500 |
| Rondoni John | Chief Technology Officer | 02/08/2023 | 670,300 |
| Rondoni John | Chief Technology Officer | 02/06/2023 | 875,710 |
| Phillips Bryan K | See Remarks | 01/29/2023 | 51,914 |
| Buchholz Richard | Chief Financial Officer | 01/25/2023 | 155,967 |
| Jandrich Steven | VP, Human Resources | 01/23/2023 | 470 |
| NELSON MARILYN C | Director | 01/10/2023 | 21,106 |
| Broader Shelley G. | Director | 01/10/2023 | 14,899 |
| Melenikiotou Georgia | Director | 01/10/2023 | 13,657 |
| Ellis Gary Lee | Director | 01/10/2023 | 14,899 |
| Sparks Charisse Y | Director | 01/10/2023 | 12,912 |
| Tansey Casey M | Director | 01/10/2023 | 12,912 |
| Buchholz Richard | Chief Financial Officer | 01/13/2023 | 2,994,609 |
| Buchholz Richard | Chief Financial Officer | 01/11/2023 | 130,750 |
| Rondoni John | Chief Technology Officer | 01/03/2023 | 299,520 |
| Ban Randy | Chief Commercial Officer | 01/03/2023 | 9,400 |
| Ban Randy | Chief Commercial Officer | 01/03/2023 | 2,520,953 |
| Rondoni John | Chief Technology Officer | 12/19/2022 | 170,666 |
| NELSON MARILYN C | Director | 12/16/2022 | 6,170,843 |
| Ban Randy | Chief Commercial Officer | 12/02/2022 | 9,713 |
| Ban Randy | Chief Commercial Officer | 12/05/2022 | 2,437,264 |
| Griffin Jerry C | Director | 11/11/2022 | 10,600 |
| Griffin Jerry C | Director | 11/11/2022 | 2,040,853 |
| Jandrich Steven | VP, Human Resources | 10/17/2022 | 705 |
| Herbert Timothy P. | CEO and President | 10/11/2022 | 326,264 |
| Broader Shelley G. | Director | 10/11/2022 | 14,363 |
| NELSON MARILYN C | Director | 10/11/2022 | 21,798 |
| Melenikiotou Georgia | Director | 10/11/2022 | 13,687 |
| Ellis Gary Lee | Director | 10/11/2022 | 14,870 |
| Sparks Charisse Y | Director | 10/11/2022 | 8,618 |
| Tansey Casey M | Director | 10/11/2022 | 13,687 |
| Rondoni John | Chief Technology Officer | 09/23/2022 | 5,845 |
| Melenikiotou Georgia | Director | 07/11/2022 | 13,570 |
| NELSON MARILYN C | Director | 07/11/2022 | 23,069 |
| Ellis Gary Lee | Director | 07/11/2022 | 14,927 |
| Tansey Casey M | Director | 07/11/2022 | 14,927 |
| Broader Shelley G. | Director | 07/11/2022 | 12,989 |
| Herbert Timothy P. | CEO and President | 04/18/2022 | 22,898 |
| Melenikiotou Georgia | Director | 04/08/2022 | 13,720 |
| Tansey Casey M | Director | 04/08/2022 | 14,991 |
| Broader Shelley G. | Director | 04/08/2022 | 12,958 |
| Ellis Gary Lee | Director | 04/08/2022 | 14,991 |
| NELSON MARILYN C | Director | 04/08/2022 | 23,121 |
| NELSON MARILYN C | Director | 04/01/2022 | 2,675,000 |
| Buchholz Richard | Chief Financial Officer | 04/01/2022 | 3,880,104 |
| Herbert Timothy P. | CEO and President | 03/25/2022 | 173,750 |
| Herbert Timothy P. | CEO and President | 03/29/2022 | 24,405,159 |
| Herbert Timothy P. | CEO and President | 03/28/2022 | 635,500 |
| Herbert Timothy P. | CEO and President | 03/25/2022 | 10,500 |
| Herbert Timothy P. | CEO and President | 03/29/2022 | 6,956,592 |
| Herbert Timothy P. | CEO and President | 03/28/2022 | 386,500 |
| NELSON MARILYN C | Director | 03/29/2022 | 2,599,550 |
| NELSON MARILYN C | Director | 03/28/2022 | 580,750 |
| NELSON MARILYN C | Director | 03/25/2022 | 644,776 |
| Herbert Timothy P. | CEO and President | 03/17/2022 | 4,508,040 |
| Herbert Timothy P. | CEO and President | 01/27/2022 | 78,646 |
| Phillips Bryan K | See Remarks | 01/29/2022 | 42,640 |
| Herbert Timothy P. | CEO and President | 01/24/2022 | 63,088 |
| Broader Shelley G. | Director | 01/10/2022 | 12,971 |
| NELSON MARILYN C | Director | 01/10/2022 | 22,984 |
| Melenikiotou Georgia | Director | 01/10/2022 | 13,654 |
| Ellis Gary Lee | Director | 01/10/2022 | 14,791 |
| Tansey Casey M | Director | 01/10/2022 | 14,791 |
| Ban Randy | Chief Commercial Officer | 01/05/2022 | 7,311 |
| Ban Randy | Chief Commercial Officer | 01/04/2022 | 12,058 |
| Ban Randy | Chief Commercial Officer | 01/05/2022 | 864,174 |
| Ban Randy | Chief Commercial Officer | 01/04/2022 | 1,626,000 |
| Ban Randy | Chief Commercial Officer | 12/23/2021 | 11,066 |
| Ban Randy | Chief Commercial Officer | 12/27/2021 | 2,063 |
| Ban Randy | Chief Commercial Officer | 12/23/2021 | 2,002,080 |
| Ban Randy | Chief Commercial Officer | 12/27/2021 | 340,320 |
| NELSON MARILYN C | Director | 12/07/2021 | 5,397,790 |
| Jandrich Steven | VP, Human Resources | 10/15/2021 | 1,880 |
| Broader Shelley G. | Director | 10/08/2021 | 12,938 |
| Melenikiotou Georgia | Director | 10/08/2021 | 13,631 |
| Ellis Gary Lee | Director | 10/08/2021 | 14,787 |
| Tansey Casey M | Director | 10/08/2021 | 14,787 |
| NELSON MARILYN C | Director | 10/08/2021 | 23,104 |
| Buchholz Richard | Chief Financial Officer | 09/28/2021 | 97,306 |
| Melenikiotou Georgia | Director | 08/20/2021 | 39,678 |
| Melenikiotou Georgia | Director | 08/20/2021 | 120,116 |
| Melenikiotou Georgia | Director | 08/18/2021 | 79,355 |
| Melenikiotou Georgia | Director | 08/18/2021 | 176,432 |
| Melenikiotou Georgia | Director | 08/19/2021 | 28,976 |
| Broader Shelley G. | Director | 07/09/2021 | 12,630 |
| NELSON MARILYN C | Director | 07/09/2021 | 22,288 |
| Melenikiotou Georgia | Director | 07/09/2021 | 13,187 |
| Ellis Gary Lee | Director | 07/09/2021 | 14,487 |
| Tansey Casey M | Director | 07/09/2021 | 14,487 |
| NELSON MARILYN C | Director | 04/09/2021 | 20,534 |
| Melenikiotou Georgia | Director | 04/09/2021 | 12,452 |
| Ellis Gary Lee | Director | 04/09/2021 | 13,544 |
| Tansey Casey M | Director | 04/09/2021 | 13,544 |
| Buchholz Richard | Chief Financial Officer | 03/12/2021 | 427,611 |
| Jandrich Steven | VP, Human Resources | 02/26/2021 | 407,362 |
| Jandrich Steven | VP, Human Resources | 02/26/2021 | 2,350,000 |
| Buchholz Richard | Chief Financial Officer | 02/25/2021 | 4,514,804 |
| Broader Shelley G. | Director | 01/08/2021 | 9,123 |
| Tansey Casey M | Director | 01/08/2021 | 13,587 |
| NELSON MARILYN C | Director | 01/08/2021 | 20,575 |
| Ellis Gary Lee | Director | 01/08/2021 | 13,587 |
| Melenikiotou Georgia | Director | 01/08/2021 | 12,422 |
| Ban Randy | Chief Commercial Officer | 01/04/2021 | 48,363 |
| Ban Randy | Chief Commercial Officer | 01/04/2021 | 5,498,447 |
| Buchholz Richard | Chief Financial Officer | 12/15/2020 | 571,589 |
| Buchholz Richard | Chief Financial Officer | 11/17/2020 | 514,986 |
| Herbert Timothy P. | CEO and President | 11/05/2020 | 13,099,424 |
| NELSON MARILYN C | Director | 11/03/2020 | 1,012,550 |
| Buchholz Richard | Chief Financial Officer | 10/20/2020 | 368,510 |
| NELSON MARILYN C | Director | 10/09/2020 | 130,000 |
| NELSON MARILYN C | Director | 10/08/2020 | 3,273,977 |
| Melenikiotou Georgia | Director | 10/09/2020 | 11,440 |
| Tansey Casey M | Director | 10/09/2020 | 13,650 |
| Ellis Gary Lee | Director | 10/09/2020 | 13,650 |
| Khuong Chau Quang | Director | 10/09/2020 | 11,830 |
| NELSON MARILYN C | Director | 10/09/2020 | 20,540 |
| Buchholz Richard | Chief Financial Officer | 10/09/2020 | 247,489 |
| Buchholz Richard | Chief Financial Officer | 09/22/2020 | 756,556 |
| Tansey Casey M | Director | 09/14/2020 | 1,551,211 |
| Ban Randy | Chief Commercial Officer | 09/09/2020 | 34,200 |
| Ban Randy | Chief Commercial Officer | 09/09/2020 | 3,526,268 |
| Griffin Jerry C | Director | 08/27/2020 | 3,321,732 |
| Jandrich Steven | Chief Comp Off & VP, Human Res | 08/18/2020 | 95,093 |
| Jandrich Steven | Chief Comp Off & VP, Human Res | 08/18/2020 | 330,000 |
| ORBIMED ADVISORS LLC | Director | 08/18/2020 | 4,726,157 |
| ORBIMED ADVISORS LLC | Director | 08/17/2020 | 10,200,801 |
| Khuong Chau Quang | Director | 08/18/2020 | 4,726,157 |
| Khuong Chau Quang | Director | 08/17/2020 | 10,200,801 |
| Khuong Chau Quang | Director | 08/14/2020 | 2,206,440 |
| Khuong Chau Quang | Director | 08/13/2020 | 3,215,562 |
| Khuong Chau Quang | Director | 08/12/2020 | 4,585,858 |
| ORBIMED ADVISORS LLC | Director | 08/14/2020 | 2,208,621 |
| ORBIMED ADVISORS LLC | Director | 08/13/2020 | 3,215,562 |
| ORBIMED ADVISORS LLC | Director | 08/12/2020 | 4,585,858 |
| ORBIMED ADVISORS LLC | Director | 08/11/2020 | 4,218,189 |
| ORBIMED ADVISORS LLC | Director | 08/10/2020 | 5,019,471 |
| ORBIMED ADVISORS LLC | Director | 08/07/2020 | 3,078,477 |
| Khuong Chau Quang | Director | 08/11/2020 | 4,218,189 |
| Khuong Chau Quang | Director | 08/10/2020 | 5,019,471 |
| Khuong Chau Quang | Director | 08/07/2020 | 3,078,477 |
| Herbert Timothy P. | CEO and President | 08/06/2020 | 8,452,716 |
| Jandrich Steven | Chief Comp Off & VP, Human Res | 07/21/2020 | 940 |
| Jandrich Steven | Chief Comp Off & VP, Human Res | 07/21/2020 | 98,960 |
| Buchholz Richard | Chief Financial Officer | 07/22/2020 | 265,755 |
| Buchholz Richard | Chief Financial Officer | 07/21/2020 | 6,210 |
| Buchholz Richard | Chief Financial Officer | 07/21/2020 | 298,122 |
| Jandrich Steven | Chief Comp Off & VP, Human Res | 06/23/2020 | 940 |
| Jandrich Steven | Chief Comp Off & VP, Human Res | 06/23/2020 | 96,390 |
| Buchholz Richard | Chief Financial Officer | 06/23/2020 | 24,840 |
| Buchholz Richard | Chief Financial Officer | 06/23/2020 | 1,167,008 |
| NELSON MARILYN C | Director | 06/16/2020 | 879,409 |
| NELSON MARILYN C | Director | 06/15/2020 | 2,059,081 |
| Tansey Casey M | Director | 06/15/2020 | 8,404,255 |
| Jandrich Steven | Chief Comp Off & VP, Human Res | 05/19/2020 | 940 |
| Jandrich Steven | Chief Comp Off & VP, Human Res | 05/19/2020 | 80,000 |
| Jandrich Steven | Chief Comp Off & VP, Human Res | 04/21/2020 | 1,880 |
| Jandrich Steven | Chief Comp Off & VP, Human Res | 04/21/2020 | 145,360 |
| Ban Randy | Chief Commercial Officer | 04/09/2020 | 11,400 |
| Ban Randy | Chief Commercial Officer | 04/09/2020 | 640,000 |
| Herbert Timothy P. | CEO and President | 03/17/2020 | 174,274 |
| Khuong Chau Quang | Director | 03/06/2020 | 41,759,998 |
| ORBIMED ADVISORS LLC | Director | 03/06/2020 | 41,759,998 |
| Ban Randy | Chief Commercial Officer | 03/04/2020 | 11,400 |
| Ban Randy | Chief Commercial Officer | 03/04/2020 | 865,465 |
| Khuong Chau Quang | Director | 03/04/2020 | 35,881,749 |
| Khuong Chau Quang | Director | 03/03/2020 | 6,240,750 |
| ORBIMED ADVISORS LLC | Director | 03/03/2020 | 42,122,499 |
| Tansey Casey M | Director | 02/28/2020 | 5,819,939 |
| Ban Randy | Chief Commercial Officer | 02/04/2020 | 11,400 |
| Ban Randy | Chief Commercial Officer | 02/04/2020 | 762,075 |
| Griffin Jerry C | Director | 01/22/2020 | 106,180 |
| Griffin Jerry C | Director | 01/21/2020 | 409,587 |
| Herbert Timothy P. | CEO and President | 01/14/2020 | 1,213,440 |
| Herbert Timothy P. | CEO and President | 01/13/2020 | 787,528 |
| NELSON MARILYN C | Director | 01/10/2020 | 20,561 |
| Ellis Gary Lee | Director | 01/10/2020 | 13,707 |
| Jain Mudit K. | Director | 01/10/2020 | 12,498 |
| Tansey Casey M | Director | 01/10/2020 | 13,707 |
| Khuong Chau Quang | Director | 01/10/2020 | 11,853 |
| Jain Mudit K. | Director | 01/08/2020 | 38,485 |
| Jain Mudit K. | Director | 01/06/2020 | 37,985 |
| Griffin Jerry C | Director | 01/07/2020 | 375,886 |
| Griffin Jerry C | Director | 01/06/2020 | 370,641 |
| Griffin Jerry C | Director | 12/18/2019 | 712,080 |
| NELSON MARILYN C | Director | 12/06/2019 | 1,125,750 |
| Jain Mudit K. | Director | 12/06/2019 | 37,485 |
| Jain Mudit K. | Director | 12/04/2019 | 22,317 |
| Jain Mudit K. | Director | 11/27/2019 | 21,591 |
| ORBIMED ADVISORS LLC | Director | 11/27/2019 | 3,823,990 |
| ORBIMED ADVISORS LLC | Director | 11/26/2019 | 4,941,926 |
| Khuong Chau Quang | Director | 11/27/2019 | 3,823,990 |
| Khuong Chau Quang | Director | 11/26/2019 | 4,941,926 |
| Jain Mudit K. | Director | 11/26/2019 | 222,506 |
| Jain Mudit K. | Director | 11/25/2019 | 34,235 |
| NELSON MARILYN C | Director | 11/26/2019 | 1,050,450 |
| NELSON MARILYN C | Director | 11/25/2019 | 1,974,320 |
| Ban Randy | Chief Commercial Officer | 11/18/2019 | 9,393 |
| Ban Randy | Chief Commercial Officer | 11/18/2019 | 403,529 |
| Ban Randy | Chief Commercial Officer | 10/28/2019 | 7,350 |
| Ban Randy | Chief Commercial Officer | 10/25/2019 | 13,671 |
| Ban Randy | Chief Commercial Officer | 10/29/2019 | 7,350 |
| Ban Randy | Chief Commercial Officer | 10/25/2019 | 539,493 |
| Ban Randy | Chief Commercial Officer | 10/29/2019 | 299,621 |
| Ban Randy | Chief Commercial Officer | 10/28/2019 | 292,150 |
| Herbert Timothy P. | CEO and President | 10/22/2019 | 1,394,454 |
| Tansey Casey M | Director | 10/10/2019 | 13,710 |
| NELSON MARILYN C | Director | 10/10/2019 | 20,620 |
| Khuong Chau Quang | Director | 10/10/2019 | 11,845 |
| Jain Mudit K. | Director | 10/10/2019 | 12,449 |
| Ban Randy | Chief Commercial Officer | 10/07/2019 | 1,029 |
| Ban Randy | Chief Commercial Officer | 10/07/2019 | 40,810 |
| Buchholz Richard | Chief Financial Officer | 09/30/2019 | 43,270 |
| Buchholz Richard | Chief Financial Officer | 09/30/2019 | 43,270 |
| Herbert Timothy P. | CEO and President | 09/24/2019 | 330,714 |
| NELSON MARILYN C | Director | 09/20/2019 | 2,012,700 |
| Ban Randy | Chief Commercial Officer | 09/12/2019 | 14,700 |
| Ban Randy | Chief Commercial Officer | 09/12/2019 | 616,181 |
| NELSON MARILYN C | Director | 09/09/2019 | 4,002,580 |
| Herbert Timothy P. | CEO and President | 09/06/2019 | 700,000 |
| Herbert Timothy P. | CEO and President | 09/03/2019 | 671,885 |
| Herbert Timothy P. | CEO and President | 08/27/2019 | 989,340 |
| Jain Mudit K. | Director | 08/21/2019 | 67,620 |
| Jain Mudit K. | Director | 08/20/2019 | 18,498 |
| Jain Mudit K. | Director | 08/16/2019 | 32,102 |
| Jain Mudit K. | Director | 08/19/2019 | 117,620 |
| Buchholz Richard | Chief Financial Officer | 08/19/2019 | 8,280 |
| Buchholz Richard | Chief Financial Officer | 08/19/2019 | 267,426 |
| Herbert Timothy P. | CEO and President | 08/01/2019 | 680,151 |
| Herbert Timothy P. | CEO and President | 07/23/2019 | 1,004,288 |
| Erony Joyce | Director | 07/18/2019 | 2,701,835 |
| Erony Joyce | Director | 07/17/2019 | 3,684,721 |
| Erony Joyce | Director | 07/16/2019 | 1,552,291 |
| Tansey Casey M | Director | 07/15/2019 | 13,707 |
| Khuong Chau Quang | Director | 07/15/2019 | 11,847 |
| Jain Mudit K. | Director | 07/15/2019 | 12,467 |
| Jain Mudit K. | Director | 07/15/2019 | 320,257 |
| NELSON MARILYN C | Director | 07/15/2019 | 20,388 |
| Buchholz Richard | Chief Financial Officer | 07/16/2019 | 8,280 |
| Buchholz Richard | Chief Financial Officer | 07/16/2019 | 273,360 |
| Erony Joyce | Director | 07/12/2019 | 2,736,905 |
| Erony Joyce | Director | 07/11/2019 | 2,105,163 |
| Erony Joyce | Director | 07/15/2019 | 3,626,439 |
| Erony Joyce | Director | 07/10/2019 | 3,649,430 |
| Erony Joyce | Director | 07/09/2019 | 2,507,444 |
| Erony Joyce | Director | 07/08/2019 | 6,648,336 |
| Herbert Timothy P. | CEO and President | 07/03/2019 | 650,000 |
| NELSON MARILYN C | Director | 07/08/2019 | 1,258,339 |
| NELSON MARILYN C | Director | 07/03/2019 | 396,691 |
| Herbert Timothy P. | CEO and President | 06/25/2019 | 1,467,738 |
| Buchholz Richard | Chief Financial Officer | 06/17/2019 | 8,280 |
| Buchholz Richard | Chief Financial Officer | 06/17/2019 | 225,498 |
| Ban Randy | Senior VP, Sales and Marketing | 06/04/2019 | 161,956 |
| Ban Randy | Senior VP, Sales and Marketing | 06/03/2019 | 391,908 |
| Erony Joyce | Director | 05/31/2019 | 1,933,359 |
| Erony Joyce | Director | 05/30/2019 | 1,777,928 |
| Erony Joyce | Director | 05/29/2019 | 1,112,129 |
| Erony Joyce | Director | 05/28/2019 | 32,470 |
| Erony Joyce | Director | 05/24/2019 | 1,246,226 |
| Herbert Timothy P. | CEO and President | 05/28/2019 | 1,313,812 |
| Erony Joyce | Director | 05/23/2019 | 7,398 |
| Erony Joyce | Director | 05/22/2019 | 1,434,948 |
| Erony Joyce | Director | 05/21/2019 | 704,606 |
| Buchholz Richard | Chief Financial Officer | 05/20/2019 | 8,280 |
| Buchholz Richard | Chief Financial Officer | 05/20/2019 | 200,200 |
| Ban Randy | Senior VP, Sales and Marketing | 05/02/2019 | 81,899 |
| Ban Randy | Senior VP, Sales and Marketing | 05/01/2019 | 252,656 |
| Ban Randy | Senior VP, Sales and Marketing | 05/03/2019 | 170,034 |
| Herbert Timothy P. | CEO and President | 04/22/2019 | 438,207 |
| Herbert Timothy P. | CEO and President | 04/16/2019 | 824,538 |
| Buchholz Richard | Chief Financial Officer | 04/16/2019 | 8,280 |
| Buchholz Richard | Chief Financial Officer | 04/16/2019 | 224,204 |
| Tansey Casey M | Director | 04/10/2019 | 13,741 |
| Khuong Chau Quang | Director | 04/10/2019 | 11,849 |
| Jain Mudit K. | Director | 04/10/2019 | 12,461 |
| NELSON MARILYN C | Director | 04/10/2019 | 19,971 |
| NELSON MARILYN C | Director | 04/10/2019 | 2,595,698 |
| Ban Randy | Senior VP, Sales and Marketing | 04/05/2019 | 517,030 |
| NELSON MARILYN C | Director | 04/01/2019 | 4,712,495 |
| NELSON MARILYN C | Director | 04/02/2019 | 3,189,967 |
| Ban Randy | Sr VP, Sales & Marketing | 04/02/2019 | 251,382 |
| Ban Randy | Sr VP, Sales & Marketing | 04/01/2019 | 263,736 |
| Buchholz Richard | Chief Financial Officer | 03/20/2019 | 4,140 |
| Buchholz Richard | Chief Financial Officer | 03/20/2019 | 112,500 |
| Herbert Timothy P. | CEO and President | 03/19/2019 | 847,042 |
| ORBIMED ADVISORS LLC | Director | 03/07/2019 | 3,752,672 |
| ORBIMED ADVISORS LLC | Director | 03/08/2019 | 16,760,840 |
| Khuong Chau Quang | Director | 03/08/2019 | 16,760,840 |
| Khuong Chau Quang | Director | 03/07/2019 | 3,752,672 |
| Tansey Casey M | Director | 03/07/2019 | 1,369,395 |
| Buchholz Richard | Chief Financial Officer | 02/20/2019 | 4,140 |
| Buchholz Richard | Chief Financial Officer | 02/20/2019 | 113,740 |
| Herbert Timothy P. | CEO and President | 02/19/2019 | 860,100 |
| Erony Joyce | Director | 02/05/2019 | 2,046,136 |
| Erony Joyce | Director | 02/04/2019 | 879,260 |
| Erony Joyce | Director | 02/01/2019 | 810,520 |
| Erony Joyce | Director | 01/31/2019 | 1,072,716 |
| Erony Joyce | Director | 01/28/2019 | 1,864,330 |
| Erony Joyce | Director | 01/30/2019 | 691,075 |
| Erony Joyce | Director | 01/29/2019 | 1,003,636 |
| Erony Joyce | Director | 01/25/2019 | 1,135,015 |
| Erony Joyce | Director | 01/24/2019 | 1,503,984 |
| Erony Joyce | Director | 01/23/2019 | 669,318 |
| Buchholz Richard | Chief Financial Officer | 01/22/2019 | 12,420 |
| Buchholz Richard | Chief Financial Officer | 01/22/2019 | 325,080 |
| Erony Joyce | Director | 01/22/2019 | 1,128,791 |
| Erony Joyce | Director | 01/18/2019 | 3,560,253 |
| Erony Joyce | Director | 01/17/2019 | 10,911,170 |
| Erony Joyce | Director | 01/15/2019 | 5,601,527 |
| Erony Joyce | Director | 01/14/2019 | 4,284,421 |
| Erony Joyce | Director | 01/16/2019 | 4,941,155 |
| Erony Joyce | Director | 01/18/2018 | 3,560,253 |
| Erony Joyce | Director | 01/17/2018 | 10,911,170 |
| Erony Joyce | Director | 01/22/2018 | 1,128,791 |
| Herbert Timothy P. | CEO and President | 01/15/2019 | 730,430 |
| Erony Joyce | Director | 01/16/2018 | 4,941,155 |
| Erony Joyce | Director | 01/15/2018 | 5,601,527 |
| Erony Joyce | Director | 01/14/2018 | 4,284,421 |
| Ban Randy | Senior VP, Sales and Marketing | 01/15/2019 | 7,350 |
| Ban Randy | Senior VP, Sales and Marketing | 01/14/2019 | 7,350 |
| Ban Randy | Senior VP, Sales and Marketing | 01/15/2019 | 243,830 |
| Ban Randy | Senior VP, Sales and Marketing | 01/14/2019 | 242,109 |
| Tansey Casey M | Director | 01/10/2019 | 13,741 |
| NELSON MARILYN C | Director | 01/10/2019 | 19,983 |
| Jain Mudit K. | Director | 01/10/2019 | 12,483 |
| Khuong Chau Quang | Director | 01/10/2019 | 11,831 |
| Herbert Timothy P. | CEO and President | 12/18/2018 | 643,213 |
| Griffin Jerry C | Director | 12/11/2018 | 48,880 |
| Khuong Chau Quang | Director | 12/11/2018 | 23,115,426 |
| ORBIMED ADVISORS LLC | Director | 12/11/2018 | 23,115,426 |
| Ban Randy | Senior VP, Sales and Marketing | 11/19/2018 | 14,700 |
| Ban Randy | Senior VP, Sales and Marketing | 11/19/2018 | 203,969 |
| Ban Randy | Senior VP, Sales and Marketing | 11/20/2018 | 199,770 |
| Herbert Timothy P. | CEO and President | 11/20/2018 | 598,382 |
| NELSON MARILYN C | Director | 10/10/2018 | 19,975 |
| Tansey Casey M | Director | 10/10/2018 | 13,723 |
| Jain Mudit K. | Director | 10/10/2018 | 12,464 |
| Khuong Chau Quang | Director | 10/10/2018 | 11,855 |
| Tansey Casey M | Director | 07/12/2018 | 8,901 |
| Jain Mudit K. | Director | 07/12/2018 | 8,084 |
| Khuong Chau Quang | Director | 07/12/2018 | 7,697 |
| NELSON MARILYN C | Director | 07/12/2018 | 12,126 |
| NELSON MARILYN C | Director | 05/07/2018 | 1,000,000 |
| Khuong Chau Quang | Director | 05/07/2018 | 5,000,000 |
| ORBIMED ADVISORS LLC | 10% Owner | 05/07/2018 | 5,000,000 |
| McCormick Shawn | Director | 05/07/2018 | 48,000 |
| Amzak Health Investors, LLC | 10% Owner | 05/07/2018 | 2,000,000 |
| Tansey Casey M | Director | 05/07/2018 | 3,000,000 |
| Mead Dana G Jr. | Director | 05/07/2018 | 320,000 |
| Erony Joyce | Director | 05/07/2018 | 2,000,000 |
| Herbert Timothy P. | CEO and President | 05/07/2018 | 5,600 |
| Jandrich Steven | Chief Comp Off & VP, Human Res | 05/07/2018 | 5,600 |
| Jandrich Steven | Chief Comp Off & VP, Human Res | 05/07/2018 | 5,600 |
| Jandrich Steven | Chief Comp Off & VP, Human Res | 05/07/2018 | 21,600 |
| Buchholz Richard | Chief Financial Officer | 05/07/2018 | 76,000 |
| Ban Randy | Senior VP, Sales and Marketing | 05/07/2018 | 14,400 |
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FUNDS WITH A POSITION IN INSPIRE MEDICAL SYSTEMS, INC.
| Fund | # Shares Owned | % of Portfolio | % Change | Investing Style |
|---|---|---|---|---|
| BLACKROCK INC. | 1,857,916 | 0.00563% | -1.75% | Other |
| FARALLON CAPITAL MANAGEMENT LLC | 626,854 | 0.61% | Exited | Event Driven, Value |
| GEODE CAPITAL MANAGEMENT, LLC | 480,526 | 0.00565% | 3.94% | Other |
| BAMCO INC /NY/ | 347,300 | 0.13% | 65.38% | Growth At A Reasonable Price |
| BALYASNY ASSET MANAGEMENT L.P. | 315,098 | 0.07% | 309.35% | Event Driven |
| AQR CAPITAL MANAGEMENT LLC | 231,845 | 0.05% | 152.68% | Other |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 142,881 | 0.31% | Exited | Growth |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 85,000 | 0.02% | -32% | Other |
| RENAISSANCE TECHNOLOGIES LLC | 73,600 | 0.02% | -32.85% | Other |
| D. E. SHAW & CO., INC. | 50,100 (Put) | 0.00627% | -16.64% | Other |
| D. E. SHAW & CO., INC. | 23,283 | 0.00291% | -26.06% | Other |
| OCONNOR, A DISTINCT BUSINESS UNIT OF UBS ASSET MANAGEMENT AMERICAS (LLC) | 12,000 (Call) | 0.00162% | New | Value |
| OCONNOR, A DISTINCT BUSINESS UNIT OF UBS ASSET MANAGEMENT AMERICAS (LLC) | 4,585 | 0.04% | -43.29% | Value |
| BRIDGEWATER ASSOCIATES, LP | 5,292 | 0.0037% | -9.06% | Other |
| TUDOR INVESTMENT CORP ET AL | 4,870 | 0.00334% | New | Event Driven, Other |
| TUDOR INVESTMENT CORP ET AL | 3,200 (Put) | 0.00219% | New | Event Driven, Other |
| DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C) | 2,813 | 0.00626% | New | Other |
| D. E. SHAW & CO., INC. | 1,300 (Call) | 0.00024% | Exited | Other |
| ALPINE GLOBAL MANAGEMENT, LLC | 1,125 | 0.05% | Exited | Event Driven |
CHANGE IN SHARES OUTSTANDING FOR INSPIRE MEDICAL SYSTEMS, INC.
STOCK BUYBACKS FOR INSPIRE MEDICAL SYSTEMS, INC.
Period of Report
Previous Period
% Change in Shares
10-K/10-Q Filings
Quarter
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Period of Report: 03/31/2024
10-K/10-Q Filings: View
Previous Period
% Change in Shares
Quarter
12/31/2023
0.32%
1Q
09/30/2023
0.85%
2Q
06/30/2023
1.32%
3Q
03/31/2023
1.81%
4Q
12/31/2022
2.33%
5Q
09/30/2022
4.92%
6Q
06/30/2022
7.32%
7Q
03/31/2022
7.62%
8Q
12/31/2021
8.18%
9Q
09/30/2021
8.48%
10Q
06/30/2021
8.76%
11Q
03/31/2021
9.10%
12Q
12/31/2020
9.72%
13Q
09/30/2020
10.36%
14Q
06/30/2020
12.65%
15Q
03/31/2020
22.55%
16Q
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BUYBACK ANNOUNCEMENT(S) FOR INSPIRE MEDICAL SYSTEMS, INC.
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