Incyte Corporation (INCY) NASDAQ
$63.13 - (-)
Market Cap: $12.16B
As of 09/11/24 04:00 PM EDT. Market closed.
Incyte Corporation (INCY)
NASDAQ
$63.13
- (-)
Market Cap: $12.16B
As of 09/11/24 04:00 PM EDT. Market closed.
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Incyte is a global biopharmaceutical company based in Delaware, Switzerland, Japan, and Canada, specializing in the discovery, development, and commercialization of proprietary therapeutics. The company focuses on two main therapeutic areas - Hematology/Oncology and Inflammation and Autoimmunity. They have multiple approved products and clinical development programs in the field of hematology and ... read more
COMPANY PROFILE
Sector
Healthcare
Industry
Biotechnology
CEO
Mr. Herve Hoppenot
Full Time Employees
2,524
CEO Compensation (Base)
$1.29M
CEO Compensation (Total)
$16.66M
Sector
Healthcare
Industry
Biotechnology
CEO
Mr. Herve Hoppenot
Full Time Employees
2,524
CEO Compensation (Base)
$1.29M
CEO Compensation (Total)
$16.66M
URL
Address
1801 Augustine Cut-Off, DE, Wilmington, 19803.
PRICE CHART FOR INCYTE CORPORATION
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NEWS
INSIDEARBITRAGE ARTICLES
KEY STATS
Open
$62.19
Previous Close
$63.13
Days Range
$61.67 - $63.16
52 week range
$50.27 - $70.36
Volume
1,410,941
Avg. Volume (30 days)
2,629,346
Market Cap
$12.16B
Dividend Yield
-
P/E
153.98
Shares Outstanding
192,598,000
Open
$62.19
Previous Close
$63.13
Days Range
$61.67 - $63.16
52 week range
$50.27 - $70.36
Volume
1,410,941
Avg. Volume (30 days)
2,629,346
Market Cap
$12.16B
Dividend Yield
-
P/E
153.98
Shares Outstanding
192,598,000
FINANCIAL STATEMENTS FOR INCYTE CORPORATION
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INSIDER TRANSACTIONS FOR INCYTE CORPORATION
| Owner | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| Stein Steven H | EVP & Chief Medical Officer | Aug 12, 2024 | Sale | $60.63 | 11,608 | 703,793 | 90,011 | Aug 14, 2024, 03:37 PM |
| Iyengar Vijay K | EVP, GMAPPS | Jul 25, 2024 | Sale | $70.00 | 15,571 | 1,089,970 | 36,701 | Jul 29, 2024, 03:50 PM |
| Stein Steven H | EVP & Chief Medical Officer | Jul 15, 2024 | Option Exercise | $64.25 | 1,555 | 99,909 | 101,619 | Jul 17, 2024, 12:31 PM |
| Tray Thomas | Principal Accounting Officer | Jul 15, 2024 | Option Exercise | $64.25 | 466 | 29,941 | 25,397 | Jul 17, 2024, 12:30 PM |
| SWAIN PAULA J | EVP, Human Resources | Jul 15, 2024 | Option Exercise | $64.25 | 549 | 35,273 | 86,076 | Jul 17, 2024, 12:29 PM |
| CAGNONI PABLO J | President, R&D | Jul 15, 2024 | Option Exercise | $64.25 | 749 | 48,123 | 221,170 | Jul 17, 2024, 12:28 PM |
| Hoppenot Herve | Chairman / CEO | Jul 15, 2024 | Option Exercise | $64.25 | 4,961 | 318,744 | 496,674 | Jul 17, 2024, 12:27 PM |
| Iyengar Vijay K | EVP, GMAPPS | Jul 15, 2024 | Option Exercise | $64.25 | 549 | 35,273 | 52,272 | Jul 17, 2024, 12:26 PM |
| Stamoulis Christiana | EVP & Chief Financial Officer | Jul 15, 2024 | Option Exercise | $64.25 | 948 | 60,909 | 95,197 | Jul 17, 2024, 12:25 PM |
| Flannelly Barry P | EVP & General Manager US | Jul 15, 2024 | Option Exercise | $64.25 | 1,111 | 71,382 | 59,348 | Jul 17, 2024, 12:24 PM |
| Flannelly Barry P | EVP & General Manager US | Jul 16, 2024 | Sale | $64.19 | 1,306 | 83,832 | 58,042 | Jul 17, 2024, 12:24 PM |
| Flannelly Barry P | EVP & General Manager US | Jul 09, 2024 | Sale | $60.00 | 8,148 | 488,880 | 50,534 | Jul 11, 2024, 12:35 PM |
| Hoppenot Herve | Chairman / CEO | Jul 02, 2024 | Option Exercise | $59.02 | 41,723 | 2,462,491 | 460,610 | Jul 03, 2024, 12:20 PM |
| Flannelly Barry P | EVP & General Manager US | Jul 02, 2024 | Option Exercise | $59.02 | 7,695 | 454,159 | 58,682 | Jul 03, 2024, 12:19 PM |
| Iyengar Vijay K | EVP, GMAPPS | Jul 02, 2024 | Option Exercise | $59.02 | 5,706 | 336,768 | 45,543 | Jul 03, 2024, 12:19 PM |
| Stamoulis Christiana | EVP & Chief Financial Officer | Jul 02, 2024 | Option Exercise | $59.02 | 6,870 | 405,467 | 83,573 | Jul 03, 2024, 12:18 PM |
| Stein Steven H | EVP & Chief Medical Officer | Jul 02, 2024 | Option Exercise | $59.02 | 8,316 | 490,810 | 89,279 | Jul 03, 2024, 12:17 PM |
| SWAIN PAULA J | EVP, Human Resources | Jul 02, 2024 | Option Exercise | $59.02 | 5,560 | 328,151 | 79,347 | Jul 03, 2024, 12:17 PM |
| Tray Thomas | Principal Accounting Officer | Jul 02, 2024 | Option Exercise | $59.02 | 844 | 49,813 | 20,790 | Jul 03, 2024, 12:16 PM |
| BAKER BROS. ADVISORS LP | Director | Jun 12, 2024 | Option Exercise | $60.00 | 5,459,183 | 327,550,980 | 28,182,605 | Jun 14, 2024, 04:15 PM |
| Flannelly Barry P | EVP & General Manager US | Jun 12, 2024 | Sale | $60.00 | 19,164 | 1,149,840 | 66,377 | Jun 14, 2024, 12:17 PM |
| Schaffert Susanne | Director | Jun 12, 2024 | Option Exercise | $59.94 | 752 | 45,075 | 2,890 | Jun 14, 2024, 12:15 PM |
| Tray Thomas | Principal Accounting Officer | Jun 06, 2024 | Sale | $58.91 | 1,093 | 64,389 | 21,634 | Jun 10, 2024, 12:25 PM |
| BAKER BROS. ADVISORS LP | Director | May 07, 2024 | Option Exercise | $49.01 | 30,000 | 1,470,300 | 33,462,981 | May 09, 2024, 06:25 PM |
| Clancy Paul J | Director | Mar 28, 2024 | Option Exercise | $56.97 | 403 | 22,959 | 15,785 | Apr 02, 2024, 12:12 PM |
| HARRIGAN EDMUND | Director | Mar 28, 2024 | Option Exercise | $56.97 | 413 | 23,529 | 13,115 | Apr 02, 2024, 12:12 PM |
| Stamoulis Christiana | EVP & Chief Financial Officer | Feb 12, 2024 | Option Exercise | $57.84 | 387 | 22,384 | 82,606 | Feb 14, 2024, 12:33 PM |
| Morrissey Michael James | EVP, Head of Tech. Operations | Jan 22, 2024 | Option Exercise | $61.50 | 108 | 6,642 | 72,300 | Jan 24, 2024, 02:15 PM |
| Dickinson Jonathan Elliott | EVP, General Manager, Europe | Jan 22, 2024 | Option Exercise | $61.50 | 108 | 6,642 | 44,380 | Jan 24, 2024, 02:14 PM |
| Morrissey Michael James | EVP, Head of Tech. Operations | Jan 18, 2024 | Option Exercise | $61.18 | 11,359 | 694,944 | 72,530 | Jan 22, 2024, 01:04 PM |
| Morrissey Michael James | EVP, Head of Tech. Operations | Jan 19, 2024 | Option Exercise | $61.49 | 122 | 7,502 | 72,408 | Jan 22, 2024, 01:04 PM |
| Dickinson Jonathan Elliott | EVP, General Manager, Europe | Jan 18, 2024 | Option Exercise | $61.18 | 8,114 | 496,415 | 44,610 | Jan 22, 2024, 01:03 PM |
| Dickinson Jonathan Elliott | EVP, General Manager, Europe | Jan 19, 2024 | Option Exercise | $61.49 | 122 | 7,502 | 44,488 | Jan 22, 2024, 01:03 PM |
| Flannelly Barry P | EVP & General Manager US | Jan 17, 2024 | Option Exercise | $61.48 | 3,675 | 225,939 | 77,703 | Jan 19, 2024, 05:31 PM |
| Tray Thomas | Principal Accounting Officer | Jan 17, 2024 | Option Exercise | $61.48 | 1,021 | 62,771 | 22,415 | Jan 19, 2024, 05:30 PM |
| Dickinson Jonathan Elliott | EVP, General Manager, Europe | Jan 17, 2024 | Option Exercise | $61.48 | 101 | 6,209 | 36,496 | Jan 18, 2024, 02:27 PM |
| Dickinson Jonathan Elliott | EVP, General Manager, Europe | Jan 16, 2024 | Option Exercise | $61.34 | 101 | 6,195 | 36,597 | Jan 18, 2024, 02:27 PM |
| Morrissey Michael James | EVP, Head of Tech. Operations | Jan 17, 2024 | Option Exercise | $61.48 | 101 | 6,209 | 61,171 | Jan 18, 2024, 02:23 PM |
| Morrissey Michael James | EVP, Head of Tech. Operations | Jan 16, 2024 | Option Exercise | $61.34 | 101 | 6,195 | 61,272 | Jan 18, 2024, 02:23 PM |
| Stein Steven H | EVP & Chief Medical Officer | Jan 03, 2024 | Sale | $65.51 | 7,365 | 482,481 | 90,218 | Jan 05, 2024, 12:27 PM |
| Iyengar Vijay K | EVP, GMAPPS | Jan 02, 2024 | Sale | $65.00 | 657 | 42,705 | 43,412 | Jan 04, 2024, 01:05 PM |
| Clancy Paul J | Director | Dec 29, 2023 | Option Exercise | $62.79 | 412 | 25,869 | 15,382 | Jan 03, 2024, 12:08 PM |
| HARRIGAN EDMUND | Director | Dec 29, 2023 | Option Exercise | $62.79 | 423 | 26,560 | 12,702 | Jan 03, 2024, 12:07 PM |
| Tray Thomas | Principal Accounting Officer | Dec 13, 2023 | Sale | $62.37 | 1,067 | 66,549 | 23,436 | Dec 14, 2023, 02:11 PM |
| Tray Thomas | Principal Accounting Officer | Dec 12, 2023 | Sale | $57.36 | 210 | 12,046 | 24,503 | Dec 14, 2023, 02:11 PM |
| HARRIGAN EDMUND | Director | Sep 29, 2023 | Option Exercise | $57.77 | 389 | 22,473 | 12,279 | Oct 03, 2023, 04:06 PM |
| Clancy Paul J | Director | Sep 29, 2023 | Option Exercise | $57.77 | 379 | 21,895 | 14,970 | Oct 03, 2023, 04:02 PM |
| SWAIN PAULA J | EVP, Human Resources | Sep 01, 2023 | Sale | $65.13 | 8,449 | 550,283 | 77,530 | Sep 06, 2023, 04:00 PM |
| Stein Steven H | EVP & Chief Medical Officer | Aug 01, 2023 | Sale | $63.28 | 21,511 | 1,361,216 | 97,583 | Aug 03, 2023, 04:00 PM |
| Hoppenot Herve | Chairman / CEO | Jul 03, 2023 | Option Exercise | $62.08 | 43,467 | 2,698,431 | 391,672 | Jul 06, 2023, 04:00 PM |
| Flannelly Barry P | EVP & General Manager US | Jul 03, 2023 | Option Exercise | $62.08 | 6,304 | 391,352 | 71,710 | Jul 06, 2023, 04:00 PM |
| SWAIN PAULA J | EVP, Human Resources | Jul 03, 2023 | Option Exercise | $62.08 | 5,783 | 359,009 | 78,890 | Jul 06, 2023, 04:00 PM |
| Tray Thomas | Principal Accounting Officer | Jul 03, 2023 | Option Exercise | $62.08 | 1,136 | 70,523 | 18,524 | Jul 06, 2023, 04:00 PM |
| Stamoulis Christiana | EVP & Chief Financial Officer | Jul 03, 2023 | Option Exercise | $62.08 | 6,073 | 377,012 | 70,747 | Jul 06, 2023, 04:00 PM |
| Pasquale Maria E | EVP & General Counsel | Jul 03, 2023 | Option Exercise | $62.08 | 8,468 | 525,693 | 60,056 | Jul 06, 2023, 04:00 PM |
| Stein Steven H | EVP & Chief Medical Officer | Jul 03, 2023 | Option Exercise | $62.08 | 8,442 | 524,079 | 105,559 | Jul 06, 2023, 04:00 PM |
| Iyengar Vijay K | EVP, GMAPPS | Jul 03, 2023 | Option Exercise | $62.08 | 6,215 | 385,827 | 36,980 | Jul 06, 2023, 04:00 PM |
| Dhanak Dashyant | EVP & Chief Scientific Officer | Jul 03, 2023 | Option Exercise | $62.08 | 6,044 | 375,212 | 50,912 | Jul 06, 2023, 04:00 PM |
| HARRIGAN EDMUND | Director | Jun 30, 2023 | Option Exercise | $62.25 | 390 | 24,278 | 11,890 | Jul 05, 2023, 04:01 PM |
| BAKER BROS. ADVISORS LP | Director | Mar 13, 2023 | Option Exercise | $22.74 | 40,000 | 909,600 | 33,442,926 | Mar 15, 2023, 04:03 PM |
| Stamoulis Christiana | EVP & Chief Financial Officer | Feb 13, 2023 | Option Exercise | $80.08 | 1,179 | 94,414 | 76,791 | Feb 15, 2023, 04:00 PM |
| Pasquale Maria E | EVP & General Counsel | Jan 31, 2023 | Option Exercise | $74.78 | 802 | 59,974 | 69,326 | Feb 02, 2023, 04:00 PM |
| Pasquale Maria E | EVP & General Counsel | Jan 31, 2023 | Sale | $84.06 | 802 | 67,416 | 68,524 | Feb 02, 2023, 04:00 PM |
| Pasquale Maria E | EVP & General Counsel | Jan 30, 2023 | Option Exercise | $73.39 | 60,024 | 4,405,224 | 82,898 | Feb 01, 2023, 04:00 PM |
| Pasquale Maria E | EVP & General Counsel | Jan 30, 2023 | Sale | $84.74 | 60,024 | 5,086,569 | 68,524 | Feb 01, 2023, 04:00 PM |
| Iyengar Vijay K | EVP, GMAPPS | Jan 26, 2023 | Option Exercise | $68.62 | 7,000 | 480,340 | 49,835 | Jan 30, 2023, 04:00 PM |
| Iyengar Vijay K | EVP, GMAPPS | Jan 26, 2023 | Sale | $85.00 | 7,000 | 595,000 | 42,835 | Jan 30, 2023, 04:00 PM |
| Dhanak Dashyant | EVP & Chief Scientific Officer | Jan 26, 2023 | Sale | $85.00 | 2,419 | 205,615 | 53,263 | Jan 30, 2023, 04:00 PM |
| Dickinson Jonathan Elliott | EVP, General Manager, Europe | Jan 19, 2023 | Option Exercise | $83.88 | 105 | 8,807 | 30,179 | Jan 23, 2023, 04:00 PM |
| Morrissey Michael James | EVP, Head of Tech. Operations | Jan 19, 2023 | Option Exercise | $83.88 | 105 | 8,807 | 55,214 | Jan 23, 2023, 04:00 PM |
| Dickinson Jonathan Elliott | EVP, General Manager, Europe | Jan 17, 2023 | Option Exercise | $81.26 | 87 | 7,070 | 30,284 | Jan 18, 2023, 04:00 PM |
| Dickinson Jonathan Elliott | EVP, General Manager, Europe | Jan 15, 2023 | Option Exercise | $81.26 | 87 | 7,070 | 30,371 | Jan 18, 2023, 04:00 PM |
| Morrissey Michael James | EVP, Head of Tech. Operations | Jan 17, 2023 | Option Exercise | $81.26 | 87 | 7,070 | 55,319 | Jan 18, 2023, 04:00 PM |
| Morrissey Michael James | EVP, Head of Tech. Operations | Jan 15, 2023 | Option Exercise | $81.26 | 87 | 7,070 | 55,406 | Jan 18, 2023, 04:00 PM |
| Morrissey Michael James | EVP, Head of Tech. Operations | Jan 04, 2023 | Option Exercise | $79.08 | 117 | 9,252 | 55,493 | Jan 06, 2023, 04:00 PM |
| Stein Steven H | EVP & Chief Medical Officer | Jan 04, 2023 | Sale | $79.78 | 28,399 | 2,265,672 | 109,021 | Jan 06, 2023, 04:00 PM |
| Dickinson Jonathan Elliott | EVP, General Manager, Europe | Jan 04, 2023 | Option Exercise | $79.08 | 117 | 9,252 | 30,458 | Jan 06, 2023, 04:00 PM |
| Clancy Paul J | Director | Dec 30, 2022 | Option Exercise | $80.32 | 294 | 23,614 | 11,388 | Jan 04, 2023, 04:02 PM |
| FOUSE JACQUALYN A | Director | Dec 30, 2022 | Option Exercise | $80.32 | 252 | 20,241 | 11,473 | Jan 04, 2023, 04:02 PM |
| HARRIGAN EDMUND | Director | Dec 30, 2022 | Option Exercise | $80.32 | 302 | 24,257 | 8,669 | Jan 04, 2023, 04:02 PM |
| Iyengar Vijay K | EVP, GMAPPS | Dec 23, 2022 | Option Exercise | $70.86 | 14,866 | 1,053,457 | 48,179 | Dec 28, 2022, 04:00 PM |
| Iyengar Vijay K | EVP, GMAPPS | Dec 23, 2022 | Sale | $80.80 | 17,324 | 1,399,739 | 40,313 | Dec 28, 2022, 04:00 PM |
| Tray Thomas | Principal Accounting Officer | Dec 19, 2022 | Sale | $82.16 | 1,223 | 100,482 | 16,606 | Dec 21, 2022, 04:00 PM |
| Dhanak Dashyant | EVP & Chief Scientific Officer | Dec 12, 2022 | Option Exercise | $82.36 | 533 | 43,898 | 50,702 | Dec 13, 2022, 04:00 PM |
| HARRIGAN EDMUND | Director | Oct 19, 2022 | Option Exercise | $69.59 | 165 | 11,482 | 8,367 | Oct 20, 2022, 04:00 PM |
| HARRIGAN EDMUND | Director | Sep 30, 2022 | Option Exercise | $66.64 | 250 | 16,660 | 8,202 | Oct 04, 2022, 04:03 PM |
| FOUSE JACQUALYN A | Director | Sep 30, 2022 | Option Exercise | $66.64 | 291 | 19,392 | 11,221 | Oct 04, 2022, 04:01 PM |
| Clancy Paul J | Director | Sep 30, 2022 | Option Exercise | $66.64 | 339 | 22,591 | 11,094 | Oct 04, 2022, 04:00 PM |
| Tray Thomas | Principal Accounting Officer | Jul 22, 2022 | Sale | $83.13 | 1,564 | 130,015 | 17,702 | Jul 26, 2022, 04:00 PM |
| Iyengar Vijay K | EVP, GMAPPS | Jul 07, 2022 | Sale | $79.38 | 5,787 | 459,372 | 40,313 | Jul 11, 2022, 04:00 PM |
| Flannelly Barry P | EVP & General Manager US | Jul 07, 2022 | Sale | $79.38 | 2,873 | 228,059 | 72,674 | Jul 11, 2022, 04:00 PM |
| Tray Thomas | Principal Accounting Officer | Jul 05, 2022 | Option Exercise | $79.25 | 987 | 78,220 | 19,266 | Jul 06, 2022, 04:13 PM |
| SWAIN PAULA J | EVP, Human Resources | Jul 05, 2022 | Option Exercise | $79.25 | 2,599 | 205,971 | 79,693 | Jul 06, 2022, 04:12 PM |
| Stein Steven H | EVP & Chief Medical Officer | Jul 05, 2022 | Option Exercise | $79.25 | 3,856 | 305,588 | 137,420 | Jul 06, 2022, 04:11 PM |
| Stamoulis Christiana | EVP & Chief Financial Officer | Jul 05, 2022 | Option Exercise | $79.25 | 1,124 | 89,077 | 72,659 | Jul 06, 2022, 04:10 PM |
| Pasquale Maria E | EVP & General Counsel | Jul 05, 2022 | Option Exercise | $79.25 | 3,043 | 241,158 | 63,544 | Jul 06, 2022, 04:09 PM |
| Iyengar Vijay K | EVP, GMAPPS | Jul 05, 2022 | Option Exercise | $79.25 | 2,599 | 205,971 | 46,100 | Jul 06, 2022, 04:08 PM |
| Hoppenot Herve | Chairman / CEO | Jul 05, 2022 | Option Exercise | $79.25 | 21,174 | 1,678,040 | 405,943 | Jul 06, 2022, 04:08 PM |
| Flannelly Barry P | EVP & General Manager US | Jul 05, 2022 | Option Exercise | $79.25 | 3,506 | 277,851 | 75,547 | Jul 06, 2022, 04:06 PM |
| Dhanak Dashyant | EVP & Chief Scientific Officer | Jul 05, 2022 | Option Exercise | $79.25 | 2,181 | 172,844 | 51,235 | Jul 06, 2022, 04:06 PM |
| Clancy Paul J | Director | Jun 30, 2022 | Option Exercise | $75.97 | 321 | 24,386 | 10,755 | Jul 01, 2022, 04:01 PM |
| FOUSE JACQUALYN A | Director | Jun 30, 2022 | Option Exercise | $75.97 | 275 | 20,892 | 10,930 | Jul 01, 2022, 04:01 PM |
| HARRIGAN EDMUND | Director | Jun 30, 2022 | Option Exercise | $75.97 | 236 | 17,929 | 7,952 | Jul 01, 2022, 04:01 PM |
| Stein Steven H | EVP & Chief Medical Officer | Jun 28, 2022 | Option Exercise | $75.63 | 11,488 | 868,837 | 122,335 | Jun 30, 2022, 04:00 PM |
| Pasquale Maria E | EVP & General Counsel | Apr 09, 2022 | Option Exercise | $80.95 | 517 | 41,851 | 53,058 | Apr 12, 2022, 04:12 PM |
| Flannelly Barry P | EVP & General Manager US | Apr 08, 2022 | Option Exercise | $70.48 | 41,864 | 2,950,628 | 88,640 | Apr 12, 2022, 04:10 PM |
| Flannelly Barry P | EVP & General Manager US | Apr 08, 2022 | Sale | $83.49 | 43,993 | 3,672,887 | 67,292 | Apr 12, 2022, 04:10 PM |
| BAKER BROS. ADVISORS LP | Director | Mar 08, 2022 | Option Exercise | $22.05 | 40,000 | 882,000 | 33,059,604 | Mar 10, 2022, 06:02 PM |
| BAKER BROS. ADVISORS LP | Director | Mar 10, 2022 | Buy | $73.13 | 218,563 | 15,982,720 | 33,419,055 | Mar 10, 2022, 06:02 PM |
| BAKER BROS. ADVISORS LP | Director | Mar 09, 2022 | Buy | $71.72 | 70,517 | 5,057,550 | 33,217,136 | Mar 10, 2022, 06:02 PM |
| BAKER BROS. ADVISORS LP | Director | Mar 08, 2022 | Buy | $70.68 | 100,000 | 7,067,500 | 33,151,989 | Mar 10, 2022, 06:02 PM |
| BAKER BROS. ADVISORS LP | Director | Feb 22, 2022 | Buy | $68.07 | 99,800 | 6,793,536 | 33,039,604 | Feb 22, 2022, 05:45 PM |
| BAKER BROS. ADVISORS LP | Director | Feb 18, 2022 | Buy | $68.38 | 133,032 | 9,096,550 | 32,947,370 | Feb 22, 2022, 05:45 PM |
| BAKER BROS. ADVISORS LP | Director | Feb 17, 2022 | Buy | $67.74 | 292,972 | 19,844,806 | 32,824,461 | Feb 22, 2022, 05:45 PM |
| Stamoulis Christiana | EVP & Chief Financial Officer | Feb 11, 2022 | Option Exercise | $66.76 | 1,177 | 78,577 | 56,616 | Feb 15, 2022, 04:21 PM |
| Dickinson Jonathan Elliott | EVP, General Manager, Europe | Jan 31, 2022 | Sale | $74.19 | 7,375 | 547,151 | 30,214 | Feb 02, 2022, 04:25 PM |
| Morrissey Michael James | EVP, Head of Tech. Operations | Jan 24, 2022 | Option Exercise | $75.34 | 78 | 5,877 | 55,610 | Jan 26, 2022, 04:11 PM |
| Dickinson Jonathan Elliott | EVP, General Manager, Europe | Jan 24, 2022 | Option Exercise | $75.34 | 78 | 5,877 | 37,589 | Jan 26, 2022, 04:09 PM |
| Morrissey Michael James | EVP, Head of Tech. Operations | Jan 18, 2022 | Option Exercise | $75.01 | 202 | 15,152 | 48,830 | Jan 20, 2022, 04:21 PM |
| Dickinson Jonathan Elliott | EVP, General Manager, Europe | Jan 18, 2022 | Option Exercise | $75.01 | 202 | 15,152 | 30,809 | Jan 20, 2022, 04:18 PM |
| SWAIN PAULA J | EVP, Human Resources | Jan 07, 2022 | Option Exercise | $73.21 | 10,870 | 795,793 | 83,241 | Jan 11, 2022, 04:18 PM |
| SWAIN PAULA J | EVP, Human Resources | Jan 07, 2022 | Sale | $73.31 | 10,870 | 796,880 | 72,371 | Jan 11, 2022, 04:18 PM |
| Morrissey Michael James | EVP, Head of Tech. Operations | Jan 04, 2022 | Option Exercise | $71.81 | 136 | 9,766 | 48,931 | Jan 06, 2022, 04:28 PM |
| Dickinson Jonathan Elliott | EVP, General Manager, Europe | Jan 04, 2022 | Option Exercise | $71.81 | 136 | 9,766 | 30,910 | Jan 06, 2022, 04:26 PM |
| SWAIN PAULA J | EVP, Human Resources | Jan 04, 2022 | Option Exercise | $73.21 | 9,319 | 682,244 | 81,690 | Jan 05, 2022, 04:25 PM |
| SWAIN PAULA J | EVP, Human Resources | Jan 04, 2022 | Sale | $73.46 | 9,319 | 684,574 | 72,371 | Jan 05, 2022, 04:25 PM |
| DIXON WENDY L | Director | Dec 31, 2021 | Option Exercise | $73.40 | 260 | 19,084 | 17,519 | Jan 04, 2022, 04:15 PM |
| DIXON WENDY L | Director | Dec 23, 2021 | Option Exercise | $73.25 | 20,000 | 1,465,000 | 37,259 | Dec 27, 2021, 04:11 PM |
| DIXON WENDY L | Director | Dec 23, 2021 | Sale | $22.05 | 20,000 | 441,000 | 17,259 | Dec 27, 2021, 04:11 PM |
| BAKER BROS. ADVISORS LP | Director | Dec 16, 2021 | Buy | $71.96 | 169,315 | 12,184,412 | 29,856,824 | Dec 17, 2021, 06:30 PM |
| BAKER BROS. ADVISORS LP | Director | Dec 15, 2021 | Buy | $71.51 | 350,332 | 25,052,340 | 29,687,509 | Dec 17, 2021, 06:30 PM |
| BAKER BROS. ADVISORS LP | Director | Dec 17, 2021 | Buy | $72.80 | 1,075,872 | 78,322,147 | 30,932,696 | Dec 17, 2021, 06:30 PM |
| Dhanak Dashyant | EVP & Chief Scientific Officer | Dec 10, 2021 | Option Exercise | $65.40 | 533 | 34,858 | 33,464 | Dec 14, 2021, 04:23 PM |
| Dhanak Dashyant | EVP & Chief Scientific Officer | Oct 01, 2021 | Sale | $68.67 | 389 | 26,713 | 31,263 | Oct 04, 2021, 04:41 PM |
| HARRIGAN EDMUND | Director | Sep 30, 2021 | Option Exercise | $68.78 | 237 | 16,301 | 5,079 | Oct 04, 2021, 04:36 PM |
| FOUSE JACQUALYN A | Director | Sep 30, 2021 | Option Exercise | $68.78 | 271 | 18,639 | 7,942 | Oct 04, 2021, 04:32 PM |
| DIXON WENDY L | Director | Sep 30, 2021 | Option Exercise | $68.78 | 244 | 16,782 | 17,259 | Oct 04, 2021, 04:28 PM |
| Clancy Paul J | Director | Sep 30, 2021 | Option Exercise | $68.78 | 321 | 22,078 | 7,621 | Oct 04, 2021, 04:26 PM |
| Pasquale Maria E | EVP & General Counsel | Sep 24, 2021 | Option Exercise | $65.36 | 382 | 24,968 | 36,187 | Sep 28, 2021, 08:18 AM |
| SWAIN PAULA J | EVP, Human Resources | Sep 20, 2021 | Option Exercise | $73.21 | 1,356 | 99,273 | 60,959 | Sep 21, 2021, 04:09 PM |
| Dhanak Dashyant | EVP & Chief Scientific Officer | Sep 01, 2021 | Sale | $76.71 | 388 | 29,763 | 31,652 | Sep 03, 2021, 07:40 AM |
| Dhanak Dashyant | EVP & Chief Scientific Officer | Aug 02, 2021 | Sale | $77.49 | 389 | 30,144 | 32,040 | Aug 04, 2021, 04:16 PM |
| Iyengar Vijay K | EVP GPS, BD, & Licensing | Jul 29, 2021 | Sale | $78.29 | 4,911 | 384,482 | 27,005 | Aug 02, 2021, 04:14 PM |
| Trower Paul | Principal Accounting Officer | Jul 06, 2021 | Option Exercise | $83.34 | 104 | 8,667 | 32,268 | Jul 07, 2021, 06:39 PM |
| Trower Paul | Principal Accounting Officer | Jul 02, 2021 | Option Exercise | $83.58 | 872 | 72,882 | 32,372 | Jul 07, 2021, 06:39 PM |
| Wenqing Yao | EVP, Head of Discovery Chem | Jul 06, 2021 | Option Exercise | $83.34 | 405 | 33,753 | 98,575 | Jul 07, 2021, 05:54 PM |
| Wenqing Yao | EVP, Head of Discovery Chem | Jul 02, 2021 | Option Exercise | $83.58 | 2,953 | 246,812 | 98,980 | Jul 07, 2021, 05:54 PM |
| Stein Steven H | EVP & Chief Medical Officer | Jul 06, 2021 | Option Exercise | $83.34 | 402 | 33,503 | 102,163 | Jul 07, 2021, 05:43 PM |
| Stein Steven H | EVP & Chief Medical Officer | Jul 02, 2021 | Option Exercise | $83.58 | 2,953 | 246,812 | 102,565 | Jul 07, 2021, 05:43 PM |
| SWAIN PAULA J | EVP, Human Resources | Jul 06, 2021 | Option Exercise | $83.34 | 273 | 22,752 | 59,603 | Jul 07, 2021, 04:44 PM |
| SWAIN PAULA J | EVP, Human Resources | Jul 02, 2021 | Option Exercise | $83.58 | 1,990 | 166,324 | 59,876 | Jul 07, 2021, 04:44 PM |
| Pasquale Maria E | EVP & General Counsel | Jul 02, 2021 | Option Exercise | $83.58 | 2,241 | 187,303 | 35,805 | Jul 07, 2021, 04:34 PM |
| Iyengar Vijay K | EVP GPS, BD, & Licensing | Jul 06, 2021 | Option Exercise | $83.34 | 401 | 33,419 | 31,916 | Jul 07, 2021, 04:28 PM |
| Iyengar Vijay K | EVP GPS, BD, & Licensing | Jul 02, 2021 | Option Exercise | $83.58 | 1,990 | 166,324 | 32,317 | Jul 07, 2021, 04:28 PM |
| Hoppenot Herve | Chairman / CEO | Jul 06, 2021 | Option Exercise | $83.34 | 1,562 | 130,177 | 329,877 | Jul 07, 2021, 04:23 PM |
| Hoppenot Herve | Chairman / CEO | Jul 02, 2021 | Option Exercise | $83.58 | 16,089 | 1,344,719 | 331,439 | Jul 07, 2021, 04:23 PM |
| Flannelly Barry P | EVP & General Manager US | Jul 06, 2021 | Option Exercise | $83.34 | 273 | 22,752 | 55,880 | Jul 07, 2021, 04:14 PM |
| Flannelly Barry P | EVP & General Manager US | Jul 02, 2021 | Option Exercise | $83.58 | 1,990 | 166,324 | 56,153 | Jul 07, 2021, 04:14 PM |
| Dhanak Dashyant | EVP & Chief Scientific Officer | Jul 02, 2021 | Option Exercise | $83.58 | 1,573 | 131,471 | 32,429 | Jul 07, 2021, 04:09 PM |
| Dhanak Dashyant | EVP & Chief Scientific Officer | Jul 01, 2021 | Sale | $84.09 | 396 | 33,300 | 26,149 | Jul 02, 2021, 07:15 PM |
| HARRIGAN EDMUND | Director | Jun 30, 2021 | Option Exercise | $84.13 | 208 | 17,499 | 4,842 | Jul 02, 2021, 07:32 AM |
| DIXON WENDY L | Director | Jun 30, 2021 | Option Exercise | $84.13 | 214 | 18,004 | 17,015 | Jul 02, 2021, 07:23 AM |
| FOUSE JACQUALYN A | Director | Jun 30, 2021 | Option Exercise | $84.13 | 238 | 20,023 | 7,671 | Jul 02, 2021, 07:19 AM |
| Clancy Paul J | Director | Jun 30, 2021 | Option Exercise | $84.13 | 283 | 23,809 | 7,300 | Jul 02, 2021, 07:16 AM |
| Stein Steven H | EVP & Chief Medical Officer | Jun 28, 2021 | Option Exercise | $85.61 | 22,079 | 1,890,183 | 97,665 | Jun 30, 2021, 04:14 PM |
| Wenqing Yao | EVP, Head of Discovery Chem | Jun 28, 2021 | Option Exercise | $85.61 | 22,806 | 1,952,422 | 121,274 | Jun 30, 2021, 04:11 PM |
| Wenqing Yao | EVP, Head of Discovery Chem | Jun 29, 2021 | Sale | $85.37 | 27,194 | 2,321,552 | 94,080 | Jun 30, 2021, 04:11 PM |
| Pasquale Maria E | EVP & General Counsel | Jun 18, 2021 | Option Exercise | $65.36 | 255 | 16,667 | 30,193 | Jun 22, 2021, 04:04 PM |
| FOUSE JACQUALYN A | Director | Mar 31, 2021 | Option Exercise | $81.27 | 251 | 20,399 | 5,510 | Apr 01, 2021, 05:53 PM |
| HARRIGAN EDMUND | Director | Mar 31, 2021 | Option Exercise | $81.27 | 219 | 17,798 | 2,711 | Apr 01, 2021, 05:20 PM |
| DIXON WENDY L | Director | Mar 31, 2021 | Option Exercise | $81.27 | 225 | 18,286 | 14,878 | Apr 01, 2021, 05:09 PM |
| Clancy Paul J | Director | Mar 31, 2021 | Option Exercise | $81.27 | 298 | 24,218 | 5,094 | Apr 01, 2021, 05:07 PM |
| Morrissey Michael James | EVP, Head of Tech. Operations | Mar 29, 2021 | Sale | $81.08 | 20,000 | 1,621,600 | 45,452 | Mar 31, 2021, 04:10 PM |
| Pasquale Maria E | EVP & General Counsel | Mar 12, 2021 | Option Exercise | $65.36 | 128 | 8,366 | 30,328 | Mar 16, 2021, 04:17 PM |
| Dhanak Dashyant | EVP & Chief Scientific Officer | Mar 01, 2021 | Sale | $79.73 | 395 | 31,493 | 27,732 | Mar 03, 2021, 04:28 PM |
| Hoppenot Herve | Chairman / CEO | Feb 23, 2021 | Buy | $77.37 | 12,925 | 1,000,007 | 284,231 | Feb 23, 2021, 04:54 PM |
| Pasquale Maria E | EVP & General Counsel | Feb 16, 2021 | Option Exercise | $65.36 | 127 | 8,301 | 30,200 | Feb 18, 2021, 12:00 AM |
| Stamoulis Christiana | EVP & Chief Financial Officer | Feb 11, 2021 | Option Exercise | $84.99 | 1,210 | 102,838 | 32,611 | Feb 16, 2021, 04:40 PM |
| Dhanak Dashyant | EVP & Chief Scientific Officer | Feb 01, 2021 | Option Exercise | $65.42 | 961 | 62,869 | 29,483 | Feb 03, 2021, 04:27 PM |
| Dhanak Dashyant | EVP & Chief Scientific Officer | Feb 01, 2021 | Sale | $90.00 | 1,356 | 122,040 | 28,522 | Feb 03, 2021, 04:27 PM |
| Wenqing Yao | EVP, Head of Discovery Chem | Jan 25, 2021 | Option Exercise | $73.21 | 21,545 | 1,577,309 | 163,770 | Jan 27, 2021, 05:32 PM |
| Wenqing Yao | EVP, Head of Discovery Chem | Jan 25, 2021 | Sale | $100.00 | 21,545 | 2,154,500 | 143,784 | Jan 27, 2021, 05:32 PM |
| Stein Steven H | EVP & Chief Medical Officer | Jan 25, 2021 | Option Exercise | $68.62 | 3,795 | 260,413 | 123,539 | Jan 27, 2021, 05:09 PM |
| Stein Steven H | EVP & Chief Medical Officer | Jan 25, 2021 | Sale | $100.00 | 3,795 | 379,500 | 119,744 | Jan 27, 2021, 05:09 PM |
| Iyengar Vijay K | EVP GPS, BD, & Licensing | Jan 25, 2021 | Option Exercise | $72.86 | 4,116 | 299,892 | 31,274 | Jan 27, 2021, 05:03 PM |
| Iyengar Vijay K | EVP GPS, BD, & Licensing | Jan 25, 2021 | Sale | $99.00 | 5,116 | 506,484 | 27,158 | Jan 27, 2021, 05:03 PM |
| Flannelly Barry P | EVP & General Manager US | Jan 25, 2021 | Sale | $100.00 | 2,744 | 274,400 | 49,994 | Jan 27, 2021, 04:52 PM |
| Morrissey Michael James | EVP, Head of Tech. Operations | Jan 25, 2021 | Option Exercise | $100.50 | 78 | 7,839 | 65,452 | Jan 27, 2021, 04:46 PM |
| Dickinson Jonathan Elliott | EVP, General Manager, Europe | Jan 25, 2021 | Option Exercise | $100.50 | 78 | 7,839 | 27,135 | Jan 27, 2021, 04:43 PM |
| Morrissey Michael James | EVP, Head of Tech. Operations | Jan 19, 2021 | Option Exercise | $93.96 | 174 | 16,349 | 65,530 | Jan 20, 2021, 05:02 PM |
| Dickinson Jonathan Elliott | EVP, General Manager, Europe | Jan 19, 2021 | Option Exercise | $93.96 | 174 | 16,349 | 27,213 | Jan 20, 2021, 04:44 PM |
| Pasquale Maria E | EVP & General Counsel | Jan 11, 2021 | Option Exercise | $65.36 | 127 | 8,301 | 30,073 | Jan 13, 2021, 04:15 PM |
| Morrissey Michael James | EVP, Head of Tech. Operations | Jan 04, 2021 | Option Exercise | $86.45 | 136 | 11,757 | 48,421 | Jan 06, 2021, 04:34 PM |
| Dickinson Jonathan Elliott | EVP, General Manager, Europe | Jan 04, 2021 | Option Exercise | $86.45 | 136 | 11,757 | 21,626 | Jan 06, 2021, 04:26 PM |
| Clancy Paul J | Director | Dec 31, 2020 | Option Exercise | $86.98 | 281 | 24,441 | 4,796 | Jan 05, 2021, 04:55 PM |
| FOUSE JACQUALYN A | Director | Dec 31, 2020 | Option Exercise | $86.98 | 237 | 20,614 | 5,259 | Jan 05, 2021, 04:51 PM |
| BIENAIME JEAN JACQUES | Director | Dec 31, 2020 | Option Exercise | $86.98 | 275 | 23,920 | 8,921 | Jan 05, 2021, 04:48 PM |
| DIXON WENDY L | Director | Dec 31, 2020 | Option Exercise | $86.98 | 213 | 18,527 | 14,653 | Jan 05, 2021, 04:45 PM |
| HARRIGAN EDMUND | Director | Dec 31, 2020 | Option Exercise | $86.98 | 207 | 18,005 | 2,492 | Jan 05, 2021, 12:00 AM |
| Pasquale Maria E | EVP & General Counsel | Dec 11, 2020 | Option Exercise | $65.36 | 128 | 8,366 | 29,946 | Dec 15, 2020, 04:51 PM |
| Dhanak Dashyant | EVP & Chief Scientific Officer | Dec 10, 2020 | Option Exercise | $82.05 | 720 | 59,076 | 28,522 | Dec 14, 2020, 04:19 PM |
| Pasquale Maria E | EVP & General Counsel | Nov 12, 2020 | Option Exercise | $65.36 | 127 | 8,301 | 28,586 | Nov 16, 2020, 04:56 PM |
| BIENAIME JEAN JACQUES | Director | Nov 10, 2020 | Sale | $83.00 | 798 | 66,234 | 8,646 | Nov 12, 2020, 04:41 PM |
| Dhanak Dashyant | EVP & Chief Scientific Officer | Nov 06, 2020 | Option Exercise | $65.42 | 961 | 62,869 | 28,971 | Nov 10, 2020, 04:26 PM |
| Dhanak Dashyant | EVP & Chief Scientific Officer | Nov 06, 2020 | Sale | $85.17 | 961 | 81,848 | 28,010 | Nov 10, 2020, 04:26 PM |
| Flannelly Barry P | EVP & General Manager US | Nov 02, 2020 | Option Exercise | $48.44 | 20,000 | 968,800 | 59,984 | Nov 04, 2020, 04:15 PM |
| Flannelly Barry P | EVP & General Manager US | Nov 02, 2020 | Sale | $86.60 | 20,000 | 1,732,000 | 39,984 | Nov 04, 2020, 04:15 PM |
| Pasquale Maria E | EVP & General Counsel | Oct 09, 2020 | Option Exercise | $68.62 | 1,423 | 97,646 | 29,754 | Oct 13, 2020, 05:10 PM |
| Pasquale Maria E | EVP & General Counsel | Oct 12, 2020 | Option Exercise | $65.36 | 128 | 8,366 | 28,459 | Oct 13, 2020, 05:10 PM |
| Pasquale Maria E | EVP & General Counsel | Oct 09, 2020 | Sale | $95.00 | 1,423 | 135,185 | 28,331 | Oct 13, 2020, 05:10 PM |
| Dhanak Dashyant | EVP & Chief Scientific Officer | Oct 06, 2020 | Option Exercise | $65.42 | 961 | 62,869 | 28,971 | Oct 08, 2020, 04:21 PM |
| Dhanak Dashyant | EVP & Chief Scientific Officer | Oct 06, 2020 | Sale | $91.97 | 961 | 88,383 | 28,010 | Oct 08, 2020, 04:21 PM |
| HARRIGAN EDMUND | Director | Sep 30, 2020 | Option Exercise | $89.74 | 187 | 16,781 | 2,285 | Oct 01, 2020, 04:52 PM |
| FOUSE JACQUALYN A | Director | Sep 30, 2020 | Option Exercise | $89.74 | 219 | 19,653 | 5,022 | Oct 01, 2020, 04:48 PM |
| DIXON WENDY L | Director | Sep 30, 2020 | Option Exercise | $89.74 | 197 | 17,679 | 14,440 | Oct 01, 2020, 04:46 PM |
| Clancy Paul J | Director | Sep 30, 2020 | Option Exercise | $89.74 | 260 | 23,332 | 4,515 | Oct 01, 2020, 04:43 PM |
| BIENAIME JEAN JACQUES | Director | Sep 30, 2020 | Option Exercise | $89.74 | 254 | 22,794 | 9,444 | Oct 01, 2020, 04:40 PM |
| Pasquale Maria E | EVP & General Counsel | Sep 11, 2020 | Option Exercise | $65.36 | 127 | 8,301 | 28,331 | Sep 14, 2020, 04:19 PM |
| Pasquale Maria E | EVP & General Counsel | Sep 10, 2020 | Option Exercise | $65.36 | 2,193 | 143,334 | 30,397 | Sep 14, 2020, 04:19 PM |
| Pasquale Maria E | EVP & General Counsel | Sep 10, 2020 | Sale | $90.83 | 2,193 | 199,190 | 28,204 | Sep 14, 2020, 04:19 PM |
| Dhanak Dashyant | EVP & Chief Scientific Officer | Sep 08, 2020 | Option Exercise | $65.42 | 961 | 62,869 | 28,971 | Sep 10, 2020, 04:21 PM |
| Dhanak Dashyant | EVP & Chief Scientific Officer | Sep 08, 2020 | Sale | $88.94 | 961 | 85,471 | 28,010 | Sep 10, 2020, 04:21 PM |
| DIXON WENDY L | Director | Aug 27, 2020 | Option Exercise | $18.97 | 20,000 | 379,400 | 34,243 | Aug 31, 2020, 04:26 PM |
| DIXON WENDY L | Director | Aug 27, 2020 | Sale | $94.51 | 20,000 | 1,890,200 | 14,243 | Aug 31, 2020, 04:26 PM |
| Pasquale Maria E | EVP & General Counsel | Aug 10, 2020 | Option Exercise | $65.36 | 128 | 8,366 | 28,204 | Aug 12, 2020, 04:08 PM |
| Dhanak Dashyant | EVP & Chief Scientific Officer | Aug 06, 2020 | Option Exercise | $65.42 | 961 | 62,869 | 28,971 | Aug 10, 2020, 04:20 PM |
| Dhanak Dashyant | EVP & Chief Scientific Officer | Aug 06, 2020 | Sale | $97.80 | 961 | 93,986 | 28,010 | Aug 10, 2020, 04:20 PM |
| Wenqing Yao | EVP, Head of Discovery Chem | Jul 15, 2020 | Option Exercise | $104.25 | 639 | 66,616 | 155,619 | Jul 17, 2020, 04:31 PM |
| Trower Paul | Principal Accounting Officer | Jul 15, 2020 | Option Exercise | $104.25 | 203 | 21,163 | 24,395 | Jul 17, 2020, 04:25 PM |
| SWAIN PAULA J | EVP, Human Resources | Jul 15, 2020 | Option Exercise | $104.25 | 626 | 65,261 | 52,781 | Jul 17, 2020, 04:22 PM |
| Stein Steven H | EVP & Chief Medical Officer | Jul 15, 2020 | Option Exercise | $104.25 | 623 | 64,948 | 96,234 | Jul 17, 2020, 04:20 PM |
| Stein Steven H | EVP & Chief Medical Officer | Jul 16, 2020 | Sale | $103.83 | 766 | 79,534 | 95,468 | Jul 17, 2020, 04:20 PM |
| Hoppenot Herve | Chairman / CEO | Jul 15, 2020 | Option Exercise | $104.25 | 2,420 | 252,285 | 264,081 | Jul 17, 2020, 04:11 PM |
| Flannelly Barry P | EVP & General Manager US | Jul 15, 2020 | Option Exercise | $104.25 | 639 | 66,616 | 39,903 | Jul 17, 2020, 04:08 PM |
| Pasquale Maria E | EVP & General Counsel | Jul 10, 2020 | Option Exercise | $65.36 | 127 | 8,301 | 28,076 | Jul 14, 2020, 04:39 PM |
| Dhanak Dashyant | EVP & Chief Scientific Officer | Jul 13, 2020 | Option Exercise | $65.42 | 2,419 | 158,251 | 28,010 | Jul 14, 2020, 04:31 PM |
| Iyengar Vijay K | EVP GPS, BD, & Licensing | Jul 08, 2020 | Sale | $108.56 | 475 | 51,566 | 25,926 | Jul 08, 2020, 05:31 PM |
| Iyengar Vijay K | EVP GPS, BD, & Licensing | Jul 07, 2020 | Sale | $107.98 | 3,120 | 336,898 | 26,401 | Jul 08, 2020, 05:31 PM |
| Stein Steven H | EVP & Chief Medical Officer | Jul 07, 2020 | Option Exercise | $88.68 | 10,876 | 964,484 | 108,245 | Jul 08, 2020, 05:27 PM |
| Stein Steven H | EVP & Chief Medical Officer | Jul 08, 2020 | Sale | $108.56 | 610 | 66,222 | 96,857 | Jul 08, 2020, 05:27 PM |
| Stein Steven H | EVP & Chief Medical Officer | Jul 07, 2020 | Sale | $109.56 | 14,159 | 1,551,326 | 100,750 | Jul 08, 2020, 05:27 PM |
| Wenqing Yao | EVP, Head of Discovery Chem | Jul 06, 2020 | Option Exercise | $107.79 | 404 | 43,547 | 156,258 | Jul 07, 2020, 07:30 PM |
| Wenqing Yao | EVP, Head of Discovery Chem | Jul 02, 2020 | Option Exercise | $106.47 | 2,187 | 232,850 | 156,662 | Jul 07, 2020, 07:30 PM |
| Wenqing Yao | EVP, Head of Discovery Chem | Jul 06, 2020 | Option Exercise | $64.55 | 16,553 | 1,068,496 | 171,906 | Jul 07, 2020, 07:30 PM |
| Wenqing Yao | EVP, Head of Discovery Chem | Jul 06, 2020 | Sale | $107.32 | 16,553 | 1,776,468 | 156,258 | Jul 07, 2020, 07:30 PM |
| Trower Paul | Principal Accounting Officer | Jul 06, 2020 | Option Exercise | $107.79 | 104 | 11,210 | 24,598 | Jul 07, 2020, 07:29 PM |
| Trower Paul | Principal Accounting Officer | Jul 02, 2020 | Option Exercise | $106.47 | 564 | 60,049 | 24,702 | Jul 07, 2020, 07:29 PM |
| SWAIN PAULA J | EVP, Human Resources | Jul 06, 2020 | Option Exercise | $107.97 | 273 | 29,476 | 53,407 | Jul 07, 2020, 07:27 PM |
| SWAIN PAULA J | EVP, Human Resources | Jul 02, 2020 | Option Exercise | $106.47 | 1,474 | 156,937 | 53,680 | Jul 07, 2020, 07:27 PM |
| Stein Steven H | EVP & Chief Medical Officer | Jul 06, 2020 | Option Exercise | $107.79 | 269 | 28,996 | 103,272 | Jul 07, 2020, 07:25 PM |
| Stein Steven H | EVP & Chief Medical Officer | Jul 02, 2020 | Option Exercise | $106.47 | 1,474 | 156,937 | 103,541 | Jul 07, 2020, 07:25 PM |
| Stein Steven H | EVP & Chief Medical Officer | Jul 06, 2020 | Option Exercise | $75.52 | 33,602 | 2,537,457 | 112,882 | Jul 07, 2020, 07:25 PM |
| Stein Steven H | EVP & Chief Medical Officer | Jul 06, 2020 | Sale | $107.25 | 36,124 | 3,874,171 | 100,750 | Jul 07, 2020, 07:25 PM |
| Pasquale Maria E | EVP & General Counsel | Jul 02, 2020 | Option Exercise | $106.47 | 2,373 | 252,653 | 27,949 | Jul 07, 2020, 07:22 PM |
| Iyengar Vijay K | EVP GPS, BD, & Licensing | Jul 06, 2020 | Option Exercise | $107.79 | 404 | 43,547 | 29,521 | Jul 07, 2020, 07:20 PM |
| Iyengar Vijay K | EVP GPS, BD, & Licensing | Jul 02, 2020 | Option Exercise | $106.47 | 1,637 | 174,291 | 29,925 | Jul 07, 2020, 07:20 PM |
| Hoppenot Herve | Chairman / CEO | Jul 06, 2020 | Option Exercise | $107.79 | 1,559 | 168,045 | 266,501 | Jul 07, 2020, 07:18 PM |
| Hoppenot Herve | Chairman / CEO | Jul 02, 2020 | Option Exercise | $106.47 | 11,602 | 1,235,265 | 268,060 | Jul 07, 2020, 07:18 PM |
| Hoppenot Herve | Chairman / CEO | Jul 07, 2020 | Option Exercise | $73.21 | 89,771 | 6,572,135 | 354,907 | Jul 07, 2020, 07:18 PM |
| Hoppenot Herve | Chairman / CEO | Jul 07, 2020 | Sale | $110.00 | 89,771 | 9,874,810 | 266,501 | Jul 07, 2020, 07:18 PM |
| Flannelly Barry P | EVP & General Manager US | Jul 02, 2020 | Option Exercise | $106.47 | 1,776 | 189,091 | 40,946 | Jul 07, 2020, 07:15 PM |
| Flannelly Barry P | EVP & General Manager US | Jul 06, 2020 | Option Exercise | $107.79 | 404 | 43,547 | 40,542 | Jul 07, 2020, 07:15 PM |
| Dhanak Dashyant | EVP & Chief Scientific Officer | Jul 02, 2020 | Option Exercise | $106.47 | 1,057 | 112,539 | 25,591 | Jul 07, 2020, 07:13 PM |
| Dhanak Dashyant | EVP & Chief Scientific Officer | Jul 06, 2020 | Option Exercise | $65.42 | 961 | 62,869 | 26,552 | Jul 07, 2020, 07:13 PM |
| Dhanak Dashyant | EVP & Chief Scientific Officer | Jul 06, 2020 | Sale | $106.58 | 961 | 102,423 | 25,591 | Jul 07, 2020, 07:13 PM |
| FOUSE JACQUALYN A | Director | Jun 30, 2020 | Option Exercise | $103.97 | 202 | 21,002 | 4,803 | Jul 01, 2020, 06:02 PM |
| HARRIGAN EDMUND | Director | Jun 30, 2020 | Option Exercise | $103.97 | 152 | 15,803 | 2,098 | Jul 01, 2020, 05:09 PM |
| DIXON WENDY L | Director | Jun 30, 2020 | Option Exercise | $103.97 | 182 | 18,923 | 14,243 | Jul 01, 2020, 04:57 PM |
| Clancy Paul J | Director | Jun 30, 2020 | Option Exercise | $103.97 | 229 | 23,809 | 4,255 | Jul 01, 2020, 04:51 PM |
| BIENAIME JEAN JACQUES | Director | Jun 30, 2020 | Option Exercise | $103.97 | 208 | 21,626 | 9,190 | Jul 01, 2020, 04:45 PM |
| Hoppenot Herve | Chairman / CEO | Jun 26, 2020 | Option Exercise | $64.55 | 124,148 | 8,013,754 | 360,104 | Jun 30, 2020, 04:06 PM |
| Hoppenot Herve | Chairman / CEO | Jun 26, 2020 | Sale | $102.91 | 124,148 | 12,776,071 | 240,603 | Jun 30, 2020, 04:06 PM |
| Trower Paul | Principal Accounting Officer | Jun 23, 2020 | Option Exercise | $64.55 | 6,943 | 448,171 | 28,677 | Jun 25, 2020, 05:15 PM |
| Trower Paul | Principal Accounting Officer | Jun 23, 2020 | Sale | $110.00 | 6,943 | 763,730 | 21,734 | Jun 25, 2020, 05:15 PM |
| Flannelly Barry P | EVP & General Manager US | Jun 23, 2020 | Option Exercise | $73.21 | 599 | 43,853 | 36,461 | Jun 25, 2020, 05:09 PM |
| Flannelly Barry P | EVP & General Manager US | Jun 23, 2020 | Sale | $110.00 | 400 | 44,000 | 36,061 | Jun 25, 2020, 05:09 PM |
| Pasquale Maria E | EVP & General Counsel | Jun 19, 2020 | Option Exercise | $72.27 | 1,423 | 102,840 | 25,084 | Jun 23, 2020, 04:42 PM |
| Pasquale Maria E | EVP & General Counsel | Jun 19, 2020 | Sale | $100.00 | 1,423 | 142,300 | 23,661 | Jun 23, 2020, 04:42 PM |
| Iyengar Vijay K | EVP GPS, BD, & Licensing | Jun 19, 2020 | Option Exercise | $72.86 | 7,866 | 573,117 | 32,767 | Jun 23, 2020, 04:33 PM |
| Iyengar Vijay K | EVP GPS, BD, & Licensing | Jun 19, 2020 | Sale | $105.00 | 7,866 | 825,930 | 24,901 | Jun 23, 2020, 04:33 PM |
| Flannelly Barry P | EVP & General Manager US | Jun 19, 2020 | Option Exercise | $73.21 | 7,181 | 525,721 | 43,043 | Jun 23, 2020, 04:23 PM |
| Flannelly Barry P | EVP & General Manager US | Jun 19, 2020 | Sale | $105.00 | 7,181 | 754,005 | 35,862 | Jun 23, 2020, 04:23 PM |
| Dickinson Jonathan Elliott | EVP, General Manager, Europe | Jun 22, 2020 | Sale | $105.31 | 9,000 | 947,790 | 21,762 | Jun 23, 2020, 04:17 PM |
| Pasquale Maria E | EVP & General Counsel | Jun 12, 2020 | Option Exercise | $65.36 | 127 | 8,301 | 23,661 | Jun 16, 2020, 04:24 PM |
| Pasquale Maria E | EVP & General Counsel | Jun 10, 2020 | Option Exercise | $66.64 | 3,615 | 240,915 | 25,726 | Jun 12, 2020, 04:11 PM |
| Pasquale Maria E | EVP & General Counsel | Jun 10, 2020 | Sale | $94.51 | 3,615 | 341,649 | 23,534 | Jun 12, 2020, 04:11 PM |
| Dhanak Dashyant | EVP & Chief Scientific Officer | Jun 08, 2020 | Option Exercise | $65.42 | 961 | 62,869 | 20,948 | Jun 10, 2020, 04:34 PM |
| Dhanak Dashyant | EVP & Chief Scientific Officer | Jun 08, 2020 | Sale | $91.87 | 961 | 88,287 | 19,987 | Jun 10, 2020, 04:34 PM |
| BAKER BROS. ADVISORS LP | Director | May 28, 2020 | Buy | $102.55 | 2 | 205 | 29,313,198 | May 28, 2020, 08:07 PM |
| Pasquale Maria E | EVP & General Counsel | May 11, 2020 | Option Exercise | $65.36 | 128 | 8,366 | 23,534 | May 13, 2020, 04:38 PM |
| Dhanak Dashyant | EVP & Chief Scientific Officer | May 06, 2020 | Option Exercise | $65.42 | 961 | 62,869 | 20,948 | May 08, 2020, 04:53 PM |
| Dhanak Dashyant | EVP & Chief Scientific Officer | May 06, 2020 | Sale | $96.84 | 961 | 93,063 | 19,987 | May 08, 2020, 04:53 PM |
| BAKER BROS. ADVISORS LP | Director | Apr 28, 2020 | Option Exercise | $13.34 | 40,000 | 533,600 | 29,311,915 | Apr 29, 2020, 04:45 PM |
| Trower Paul | Principal Accounting Officer | Apr 17, 2020 | Option Exercise | $64.55 | 1,143 | 73,781 | 22,467 | Apr 21, 2020, 04:35 PM |
| Trower Paul | Principal Accounting Officer | Apr 17, 2020 | Sale | $100.00 | 1,143 | 114,300 | 21,324 | Apr 21, 2020, 04:35 PM |
| Flannelly Barry P | EVP & General Manager US | Apr 17, 2020 | Option Exercise | $73.21 | 6,583 | 481,941 | 41,925 | Apr 21, 2020, 04:28 PM |
| Flannelly Barry P | EVP & General Manager US | Apr 17, 2020 | Sale | $100.00 | 6,583 | 658,300 | 35,342 | Apr 21, 2020, 04:28 PM |
| Pasquale Maria E | EVP & General Counsel | Apr 16, 2020 | Option Exercise | $68.62 | 9,488 | 651,067 | 32,837 | Apr 20, 2020, 05:08 PM |
| Pasquale Maria E | EVP & General Counsel | Apr 17, 2020 | Option Exercise | $72.27 | 9,488 | 685,698 | 32,837 | Apr 20, 2020, 05:08 PM |
| Pasquale Maria E | EVP & General Counsel | Apr 17, 2020 | Sale | $100.00 | 9,488 | 948,800 | 22,899 | Apr 20, 2020, 05:08 PM |
| Pasquale Maria E | EVP & General Counsel | Apr 16, 2020 | Sale | $95.00 | 9,488 | 901,360 | 22,899 | Apr 20, 2020, 05:08 PM |
| Pasquale Maria E | EVP & General Counsel | Apr 14, 2020 | Option Exercise | $65.36 | 17,827 | 1,165,173 | 40,726 | Apr 15, 2020, 04:57 PM |
| Pasquale Maria E | EVP & General Counsel | Apr 13, 2020 | Option Exercise | $65.36 | 127 | 8,301 | 23,864 | Apr 15, 2020, 04:57 PM |
| Pasquale Maria E | EVP & General Counsel | Apr 14, 2020 | Sale | $90.00 | 17,827 | 1,604,430 | 22,899 | Apr 15, 2020, 04:57 PM |
| Pasquale Maria E | EVP & General Counsel | Apr 13, 2020 | Sale | $85.68 | 965 | 82,681 | 22,899 | Apr 15, 2020, 04:57 PM |
| Pasquale Maria E | EVP & General Counsel | Apr 09, 2020 | Option Exercise | $86.81 | 517 | 44,881 | 23,737 | Apr 10, 2020, 04:26 PM |
| Pasquale Maria E | EVP & General Counsel | Apr 06, 2020 | Sale | $85.00 | 1,842 | 156,570 | 24,254 | Apr 08, 2020, 04:39 PM |
| Dhanak Dashyant | EVP & Chief Scientific Officer | Apr 06, 2020 | Option Exercise | $65.42 | 3,844 | 251,474 | 23,831 | Apr 08, 2020, 04:35 PM |
| Dhanak Dashyant | EVP & Chief Scientific Officer | Apr 06, 2020 | Sale | $85.00 | 3,844 | 326,740 | 19,987 | Apr 08, 2020, 04:35 PM |
| HARRIGAN EDMUND | Director | Mar 31, 2020 | Option Exercise | $73.23 | 202 | 14,792 | 664 | Apr 02, 2020, 06:07 PM |
| SWAIN PAULA J | EVP, Human Resources | Mar 31, 2020 | Option Exercise | $64.55 | 2,329 | 150,337 | 50,132 | Apr 02, 2020, 05:32 PM |
| SWAIN PAULA J | EVP, Human Resources | Mar 31, 2020 | Sale | $71.44 | 2,329 | 166,384 | 48,493 | Apr 02, 2020, 05:32 PM |
| FOUSE JACQUALYN A | Director | Mar 31, 2020 | Option Exercise | $73.23 | 270 | 19,772 | 3,319 | Apr 02, 2020, 05:18 PM |
| DIXON WENDY L | Director | Mar 31, 2020 | Option Exercise | $73.23 | 243 | 17,795 | 12,779 | Apr 02, 2020, 05:07 PM |
| Clancy Paul J | Director | Mar 31, 2020 | Option Exercise | $73.23 | 287 | 21,017 | 2,744 | Apr 02, 2020, 05:04 PM |
| BROOKE PAUL A | Director | Mar 31, 2020 | Option Exercise | $73.23 | 327 | 23,946 | 221,911 | Apr 02, 2020, 05:01 PM |
| BIENAIME JEAN JACQUES | Director | Mar 31, 2020 | Option Exercise | $73.23 | 236 | 17,282 | 7,700 | Apr 02, 2020, 04:55 PM |
| BAKER BROS. ADVISORS LP | Director | Mar 31, 2020 | Option Exercise | $73.23 | 784 | 57,412 | 29,291,915 | Apr 01, 2020, 07:36 PM |
| Pasquale Maria E | EVP & General Counsel | Mar 11, 2020 | Option Exercise | $65.36 | 128 | 8,366 | 26,096 | Mar 13, 2020, 04:18 PM |
| BROOKE PAUL A | Director | Feb 21, 2020 | Option Exercise | $13.34 | 20,000 | 266,800 | 221,584 | Feb 25, 2020, 04:39 PM |
| SWAIN PAULA J | EVP, Human Resources | Feb 19, 2020 | Option Exercise | $64.55 | 2,500 | 161,375 | 50,993 | Feb 21, 2020, 04:11 PM |
| SWAIN PAULA J | EVP, Human Resources | Feb 19, 2020 | Sale | $80.00 | 2,500 | 200,000 | 48,493 | Feb 21, 2020, 04:11 PM |
| Stamoulis Christiana | EVP & Chief Financial Officer | Feb 11, 2020 | Option Exercise | $76.14 | 4,268 | 324,966 | 14,869 | Feb 13, 2020, 05:21 PM |
| Stamoulis Christiana | EVP & Chief Financial Officer | Feb 11, 2020 | Option Exercise | $76.14 | 780 | 59,389 | 14,089 | Feb 13, 2020, 05:21 PM |
| Pasquale Maria E | EVP & General Counsel | Feb 10, 2020 | Option Exercise | $65.36 | 127 | 8,301 | 19,087 | Feb 12, 2020, 05:00 PM |
| Wenqing Yao | EVP, Head of Discovery Chem | Feb 05, 2020 | Option Exercise | $18.32 | 17,542 | 321,369 | 112,850 | Feb 07, 2020, 04:48 PM |
| Wenqing Yao | EVP, Head of Discovery Chem | Feb 05, 2020 | Sale | $75.97 | 17,542 | 1,332,666 | 95,308 | Feb 07, 2020, 04:48 PM |
| Morrissey Michael James | EVP, Head of Tech. Operations | Jan 23, 2020 | Option Exercise | $78.24 | 64 | 5,007 | 48,557 | Jan 27, 2020, 04:30 PM |
| Dickinson Jonathan Elliott | EVP, General Manager, Europe | Jan 23, 2020 | Option Exercise | $78.24 | 64 | 5,007 | 30,351 | Jan 27, 2020, 04:12 PM |
| Morrissey Michael James | EVP, Head of Tech. Operations | Jan 17, 2020 | Option Exercise | $80.50 | 59 | 4,750 | 48,621 | Jan 22, 2020, 04:29 PM |
| Dickinson Jonathan Elliott | EVP, General Manager, Europe | Jan 17, 2020 | Option Exercise | $80.50 | 59 | 4,750 | 30,415 | Jan 22, 2020, 04:27 PM |
| SWAIN PAULA J | EVP, Human Resources | Jan 15, 2020 | Option Exercise | $64.55 | 2,500 | 161,375 | 44,112 | Jan 17, 2020, 04:20 PM |
| SWAIN PAULA J | EVP, Human Resources | Jan 15, 2020 | Sale | $81.12 | 2,500 | 202,800 | 41,612 | Jan 17, 2020, 04:20 PM |
| Pasquale Maria E | EVP & General Counsel | Jan 10, 2020 | Option Exercise | $65.36 | 127 | 8,301 | 18,960 | Jan 14, 2020, 04:54 PM |
| Dickinson Jonathan Elliott | EVP, General Manager, Europe | Jan 06, 2020 | Option Exercise | $77.34 | 111 | 8,585 | 24,733 | Jan 08, 2020, 07:24 PM |
| Morrissey Michael James | EVP, Head of Tech. Operations | Jan 06, 2020 | Option Exercise | $77.34 | 111 | 8,585 | 42,939 | Jan 08, 2020, 05:05 PM |
| FOUSE JACQUALYN A | Director | Dec 31, 2019 | Option Exercise | $87.32 | 218 | 19,036 | 3,049 | Jan 03, 2020, 04:15 PM |
| BIENAIME JEAN JACQUES | Director | Dec 31, 2019 | Option Exercise | $87.32 | 190 | 16,591 | 7,464 | Jan 03, 2020, 04:05 PM |
| BROOKE PAUL A | Director | Dec 31, 2019 | Option Exercise | $87.32 | 264 | 23,052 | 201,584 | Jan 03, 2020, 12:00 AM |
| Clancy Paul J | Director | Dec 31, 2019 | Option Exercise | $87.32 | 231 | 20,171 | 2,457 | Jan 03, 2020, 12:00 AM |
| DIXON WENDY L | Director | Dec 31, 2019 | Option Exercise | $87.32 | 196 | 17,115 | 12,536 | Jan 03, 2020, 12:00 AM |
| BAKER BROS. ADVISORS LP | Director | Dec 31, 2019 | Option Exercise | $87.32 | 632 | 55,186 | 29,291,523 | Jan 03, 2020, 12:00 AM |
| Hoppenot Herve | Chairman / CEO | Jan 02, 2020 | Option Exercise | $85.97 | 28,345 | 2,436,820 | 183,851 | Jan 03, 2020, 12:00 AM |
| SWAIN PAULA J | EVP, Human Resources | Dec 16, 2019 | Option Exercise | $64.55 | 2,500 | 161,375 | 44,112 | Dec 18, 2019, 04:59 PM |
| SWAIN PAULA J | EVP, Human Resources | Dec 16, 2019 | Sale | $91.61 | 2,500 | 229,025 | 41,612 | Dec 18, 2019, 04:59 PM |
| Pasquale Maria E | EVP & General Counsel | Dec 12, 2019 | Option Exercise | $65.36 | 77 | 5,033 | 18,833 | Dec 16, 2019, 04:35 PM |
| Dhanak Dashyant | EVP & Chief Scientific Officer | Dec 10, 2019 | Option Exercise | $95.72 | 533 | 51,019 | 13,106 | Dec 12, 2019, 04:36 PM |
| Wenqing Yao | EVP, Head of Discovery Chem | Dec 02, 2019 | Option Exercise | $18.32 | 16,835 | 308,417 | 112,143 | Dec 03, 2019, 04:32 PM |
| Wenqing Yao | EVP, Head of Discovery Chem | Nov 29, 2019 | Option Exercise | $18.32 | 3,165 | 57,983 | 98,473 | Dec 03, 2019, 04:32 PM |
| Wenqing Yao | EVP, Head of Discovery Chem | Dec 02, 2019 | Sale | $95.00 | 16,835 | 1,599,325 | 95,308 | Dec 03, 2019, 04:32 PM |
| Wenqing Yao | EVP, Head of Discovery Chem | Nov 29, 2019 | Sale | $95.00 | 3,165 | 300,675 | 95,308 | Dec 03, 2019, 04:32 PM |
| Iyengar Vijay K | EVP GPS, BD, & Licensing | Dec 02, 2019 | Option Exercise | $72.86 | 7,366 | 536,687 | 24,975 | Dec 03, 2019, 04:25 PM |
| Iyengar Vijay K | EVP GPS, BD, & Licensing | Nov 29, 2019 | Option Exercise | $72.86 | 500 | 36,430 | 18,109 | Dec 03, 2019, 04:25 PM |
| Iyengar Vijay K | EVP GPS, BD, & Licensing | Nov 29, 2019 | Sale | $95.00 | 500 | 47,500 | 17,609 | Dec 03, 2019, 04:25 PM |
| Iyengar Vijay K | EVP GPS, BD, & Licensing | Dec 02, 2019 | Sale | $95.00 | 7,366 | 699,770 | 17,609 | Dec 03, 2019, 04:25 PM |
| Flannelly Barry P | EVP & General Manager US | Nov 29, 2019 | Option Exercise | $73.21 | 600 | 43,926 | 17,579 | Dec 03, 2019, 04:20 PM |
| Flannelly Barry P | EVP & General Manager US | Dec 02, 2019 | Option Exercise | $73.21 | 6,582 | 481,868 | 23,561 | Dec 03, 2019, 04:20 PM |
| Flannelly Barry P | EVP & General Manager US | Dec 02, 2019 | Sale | $95.00 | 6,582 | 625,290 | 16,979 | Dec 03, 2019, 04:20 PM |
| Flannelly Barry P | EVP & General Manager US | Nov 29, 2019 | Sale | $95.00 | 600 | 57,000 | 16,979 | Dec 03, 2019, 04:20 PM |
| Flannelly Barry P | EVP & General Manager US | Nov 25, 2019 | Option Exercise | $48.44 | 2,142 | 103,758 | 18,699 | Nov 26, 2019, 04:31 PM |
| Flannelly Barry P | EVP & General Manager US | Nov 25, 2019 | Sale | $90.00 | 2,142 | 192,780 | 16,979 | Nov 26, 2019, 04:31 PM |
| Wenqing Yao | EVP, Head of Discovery Chem | Nov 25, 2019 | Option Exercise | $18.32 | 15,000 | 274,800 | 110,308 | Nov 26, 2019, 04:11 PM |
| Wenqing Yao | EVP, Head of Discovery Chem | Nov 25, 2019 | Sale | $90.00 | 15,000 | 1,350,000 | 95,308 | Nov 26, 2019, 04:11 PM |
| Trower Paul | Principal Accounting Officer | Nov 25, 2019 | Option Exercise | $18.32 | 15,000 | 274,800 | 32,306 | Nov 26, 2019, 04:06 PM |
| Trower Paul | Principal Accounting Officer | Nov 25, 2019 | Sale | $90.00 | 15,000 | 1,350,000 | 17,306 | Nov 26, 2019, 04:06 PM |
| SWAIN PAULA J | EVP, Human Resources | Nov 15, 2019 | Option Exercise | $64.55 | 2,500 | 161,375 | 44,112 | Nov 19, 2019, 05:45 PM |
| SWAIN PAULA J | EVP, Human Resources | Nov 15, 2019 | Sale | $86.46 | 2,500 | 216,150 | 41,612 | Nov 19, 2019, 05:45 PM |
| Pasquale Maria E | EVP & General Counsel | Nov 13, 2019 | Option Exercise | $65.36 | 76 | 4,967 | 18,756 | Nov 14, 2019, 05:32 PM |
| DIXON WENDY L | Director | Nov 06, 2019 | Option Exercise | $12.46 | 10,576 | 131,777 | 22,916 | Nov 08, 2019, 05:25 PM |
| DIXON WENDY L | Director | Nov 08, 2019 | Option Exercise | $12.46 | 41,218 | 513,576 | 35,224 | Nov 08, 2019, 05:25 PM |
| DIXON WENDY L | Director | Nov 07, 2019 | Option Exercise | $12.46 | 1,540 | 19,188 | 13,880 | Nov 08, 2019, 05:25 PM |
| DIXON WENDY L | Director | Nov 06, 2019 | Sale | $84.16 | 10,576 | 890,076 | 12,340 | Nov 08, 2019, 05:25 PM |
| DIXON WENDY L | Director | Nov 08, 2019 | Sale | $83.87 | 41,218 | 3,456,954 | 12,340 | Nov 08, 2019, 05:25 PM |
| DIXON WENDY L | Director | Nov 07, 2019 | Sale | $83.60 | 1,540 | 128,744 | 12,340 | Nov 08, 2019, 05:25 PM |
| Wenqing Yao | EVP, Head of Discovery Chem | Nov 01, 2019 | Option Exercise | $18.32 | 7,960 | 145,827 | 103,268 | Nov 05, 2019, 05:23 PM |
| Wenqing Yao | EVP, Head of Discovery Chem | Nov 01, 2019 | Sale | $85.00 | 7,960 | 676,600 | 95,308 | Nov 05, 2019, 05:23 PM |
| Trower Paul | Principal Accounting Officer | Nov 01, 2019 | Option Exercise | $18.32 | 8,500 | 155,720 | 25,806 | Nov 05, 2019, 04:33 PM |
| Trower Paul | Principal Accounting Officer | Nov 01, 2019 | Sale | $85.00 | 8,500 | 722,500 | 17,306 | Nov 05, 2019, 04:33 PM |
| Wenqing Yao | EVP, Head of Discovery Chem | Oct 29, 2019 | Option Exercise | $18.32 | 2,040 | 37,373 | 47,348 | Oct 31, 2019, 04:10 PM |
| Wenqing Yao | EVP, Head of Discovery Chem | Oct 29, 2019 | Sale | $85.00 | 2,040 | 173,400 | 45,308 | Oct 31, 2019, 04:10 PM |
| Trower Paul | Principal Accounting Officer | Oct 29, 2019 | Option Exercise | $18.32 | 16,500 | 302,280 | 25,705 | Oct 31, 2019, 04:07 PM |
| Trower Paul | Principal Accounting Officer | Oct 29, 2019 | Sale | $80.45 | 16,500 | 1,327,500 | 17,306 | Oct 31, 2019, 04:07 PM |
| Iyengar Vijay K | EVP GPS, BD, & Licensing | Oct 29, 2019 | Sale | $85.00 | 930 | 79,050 | 17,609 | Oct 31, 2019, 04:00 PM |
| SWAIN PAULA J | EVP, Human Resources | Oct 22, 2019 | Option Exercise | $64.55 | 2,500 | 161,375 | 44,112 | Oct 24, 2019, 06:52 PM |
| SWAIN PAULA J | EVP, Human Resources | Oct 22, 2019 | Sale | $80.00 | 2,500 | 200,000 | 41,612 | Oct 24, 2019, 06:52 PM |
| Pasquale Maria E | EVP & General Counsel | Oct 10, 2019 | Option Exercise | $65.36 | 77 | 5,033 | 18,680 | Oct 11, 2019, 04:40 PM |
| BAKER BROS. ADVISORS LP | Director | Sep 30, 2019 | Option Exercise | $74.23 | 728 | 54,039 | 29,291,207 | Oct 02, 2019, 05:15 PM |
| FOUSE JACQUALYN A | Director | Sep 30, 2019 | Option Exercise | $74.23 | 251 | 18,632 | 2,831 | Oct 02, 2019, 04:14 PM |
| DIXON WENDY L | Director | Sep 30, 2019 | Option Exercise | $74.23 | 225 | 16,702 | 12,340 | Oct 02, 2019, 04:12 PM |
| Clancy Paul J | Director | Sep 30, 2019 | Option Exercise | $74.23 | 266 | 19,745 | 2,226 | Oct 02, 2019, 04:08 PM |
| BROOKE PAUL A | Director | Sep 30, 2019 | Option Exercise | $74.23 | 304 | 22,566 | 201,320 | Oct 02, 2019, 04:06 PM |
| BIENAIME JEAN JACQUES | Director | Sep 30, 2019 | Option Exercise | $74.23 | 219 | 16,256 | 7,274 | Oct 02, 2019, 04:03 PM |
| SWAIN PAULA J | EVP, Human Resources | Sep 18, 2019 | Option Exercise | $64.55 | 2,500 | 161,375 | 44,112 | Sep 19, 2019, 04:34 PM |
| SWAIN PAULA J | EVP, Human Resources | Sep 18, 2019 | Sale | $80.00 | 2,500 | 200,000 | 41,612 | Sep 19, 2019, 04:34 PM |
| Flannelly Barry P | EVP & General Manager US | Sep 17, 2019 | Sale | $77.71 | 2,491 | 193,576 | 16,757 | Sep 19, 2019, 04:30 PM |
| Pasquale Maria E | EVP & General Counsel | Sep 09, 2019 | Option Exercise | $65.36 | 76 | 4,967 | 18,603 | Sep 11, 2019, 04:29 PM |
| SWAIN PAULA J | EVP, Human Resources | Aug 15, 2019 | Option Exercise | $64.55 | 2,500 | 161,375 | 44,112 | Aug 19, 2019, 04:21 PM |
| SWAIN PAULA J | EVP, Human Resources | Aug 15, 2019 | Sale | $80.96 | 2,500 | 202,400 | 41,612 | Aug 19, 2019, 04:21 PM |
| Pasquale Maria E | EVP & General Counsel | Aug 09, 2019 | Option Exercise | $65.36 | 1,223 | 79,935 | 18,527 | Aug 13, 2019, 04:35 PM |
| FRIEDMAN PAUL A | Director | Aug 06, 2019 | Option Exercise | $18.32 | 77,934 | 1,427,751 | 333,465 | Aug 06, 2019, 06:45 PM |
| FRIEDMAN PAUL A | Director | Aug 02, 2019 | Option Exercise | $18.32 | 22,066 | 404,249 | 277,597 | Aug 06, 2019, 06:45 PM |
| FRIEDMAN PAUL A | Director | Aug 06, 2019 | Sale | $82.20 | 77,934 | 6,406,175 | 255,531 | Aug 06, 2019, 06:45 PM |
| FRIEDMAN PAUL A | Director | Aug 02, 2019 | Sale | $84.41 | 22,066 | 1,862,591 | 255,531 | Aug 06, 2019, 06:45 PM |
| BIENAIME JEAN JACQUES | Director | Aug 01, 2019 | Sale | $85.16 | 1,347 | 114,711 | 7,432 | Aug 05, 2019, 04:36 PM |
| BIENAIME JEAN JACQUES | Director | Aug 02, 2019 | Sale | $84.73 | 377 | 31,943 | 7,055 | Aug 05, 2019, 04:36 PM |
| Flannelly Barry P | EVP & General Manager US | Jul 17, 2019 | Sale | $79.91 | 959 | 76,634 | 19,248 | Jul 18, 2019, 06:13 PM |
| Hoppenot Herve | Chairman / CEO | Jul 15, 2019 | Option Exercise | $81.39 | 2,400 | 195,336 | 212,196 | Jul 16, 2019, 05:07 PM |
| Wenqing Yao | EVP, Head of Discovery Chem | Jul 15, 2019 | Option Exercise | $81.39 | 639 | 52,008 | 45,308 | Jul 16, 2019, 04:57 PM |
| Trower Paul | Principal Accounting Officer | Jul 15, 2019 | Option Exercise | $81.39 | 291 | 23,684 | 17,306 | Jul 16, 2019, 04:52 PM |
| SWAIN PAULA J | EVP, Human Resources | Jul 15, 2019 | Option Exercise | $81.39 | 639 | 52,008 | 41,612 | Jul 16, 2019, 04:48 PM |
| SWAIN PAULA J | EVP, Human Resources | Jul 15, 2019 | Option Exercise | $64.55 | 2,500 | 161,375 | 44,751 | Jul 16, 2019, 04:48 PM |
| SWAIN PAULA J | EVP, Human Resources | Jul 15, 2019 | Sale | $80.00 | 2,500 | 200,000 | 42,251 | Jul 16, 2019, 04:48 PM |
| Stein Steven H | EVP & Chief Medical Officer | Jul 15, 2019 | Option Exercise | $81.39 | 409 | 33,289 | 16,473 | Jul 16, 2019, 04:45 PM |
| Flannelly Barry P | EVP & General Manager US | Jul 15, 2019 | Option Exercise | $81.39 | 430 | 34,998 | 20,207 | Jul 16, 2019, 04:42 PM |
| Wenqing Yao | EVP, Head of Discovery Chem | Jul 05, 2019 | Option Exercise | $85.28 | 404 | 34,453 | 45,947 | Jul 09, 2019, 04:54 PM |
| Trower Paul | Principal Accounting Officer | Jul 05, 2019 | Option Exercise | $85.28 | 148 | 12,621 | 17,597 | Jul 09, 2019, 04:49 PM |
| SWAIN PAULA J | EVP, Human Resources | Jul 05, 2019 | Option Exercise | $85.28 | 404 | 34,453 | 42,251 | Jul 09, 2019, 04:47 PM |
| Stein Steven H | EVP & Chief Medical Officer | Jul 05, 2019 | Option Exercise | $85.28 | 267 | 22,770 | 16,882 | Jul 09, 2019, 04:43 PM |
| Iyengar Vijay K | EVP GPS, BD, & Licensing | Jul 05, 2019 | Option Exercise | $85.28 | 273 | 23,281 | 18,539 | Jul 09, 2019, 04:40 PM |
| Hoppenot Herve | Chairman / CEO | Jul 05, 2019 | Option Exercise | $85.28 | 1,552 | 132,355 | 214,596 | Jul 09, 2019, 04:37 PM |
| Flannelly Barry P | EVP & General Manager US | Jul 05, 2019 | Option Exercise | $85.28 | 273 | 23,281 | 20,637 | Jul 09, 2019, 04:34 PM |
| Hoppenot Herve | Chairman / CEO | Jul 02, 2019 | Option Exercise | $85.01 | 2,410 | 204,874 | 216,148 | Jul 03, 2019, 03:08 PM |
| Wenqing Yao | EVP, Head of Discovery Chem | Jul 02, 2019 | Option Exercise | $85.01 | 619 | 52,621 | 46,351 | Jul 03, 2019, 02:58 PM |
| Trower Paul | Principal Accounting Officer | Jul 02, 2019 | Option Exercise | $85.01 | 336 | 28,563 | 17,745 | Jul 03, 2019, 02:54 PM |
| SWAIN PAULA J | EVP, Human Resources | Jul 02, 2019 | Option Exercise | $85.01 | 619 | 52,621 | 42,655 | Jul 03, 2019, 02:50 PM |
| Stein Steven H | EVP & Chief Medical Officer | Jul 02, 2019 | Option Exercise | $85.01 | 417 | 35,449 | 17,149 | Jul 03, 2019, 02:46 PM |
| Pasquale Maria E | EVP & General Counsel | Jul 02, 2019 | Option Exercise | $85.01 | 470 | 39,955 | 17,304 | Jul 03, 2019, 02:43 PM |
| Iyengar Vijay K | EVP GPS, BD, & Licensing | Jul 02, 2019 | Option Exercise | $85.01 | 417 | 35,449 | 18,812 | Jul 03, 2019, 02:39 PM |
| Flannelly Barry P | EVP & General Manager US | Jul 02, 2019 | Option Exercise | $85.01 | 417 | 35,449 | 20,910 | Jul 03, 2019, 02:35 PM |
| BIENAIME JEAN JACQUES | Director | Jun 28, 2019 | Option Exercise | $84.96 | 195 | 16,567 | 8,779 | Jul 02, 2019, 04:23 PM |
| BAKER BROS. ADVISORS LP | Director | Jun 28, 2019 | Option Exercise | $84.96 | 620 | 52,675 | 29,290,843 | Jul 02, 2019, 04:05 PM |
| DIXON WENDY L | Director | Jun 28, 2019 | Option Exercise | $84.96 | 208 | 17,672 | 12,115 | Jul 02, 2019, 12:00 AM |
| BROOKE PAUL A | Director | Jun 28, 2019 | Option Exercise | $84.96 | 291 | 24,723 | 201,016 | Jul 02, 2019, 12:00 AM |
| FOUSE JACQUALYN A | Director | Jun 28, 2019 | Option Exercise | $84.96 | 203 | 17,247 | 2,580 | Jul 02, 2019, 12:00 AM |
| Clancy Paul J | Director | Jun 28, 2019 | Option Exercise | $84.96 | 237 | 20,136 | 1,960 | Jul 02, 2019, 12:00 AM |
| Stein Steven H | EVP & Chief Medical Officer | Jun 24, 2019 | Sale | $87.96 | 8,357 | 735,082 | 10,805 | Jun 25, 2019, 05:46 PM |
| SWAIN PAULA J | EVP, Human Resources | Jun 17, 2019 | Option Exercise | $64.55 | 2,500 | 161,375 | 39,013 | Jun 18, 2019, 05:26 PM |
| SWAIN PAULA J | EVP, Human Resources | Jun 17, 2019 | Sale | $80.00 | 2,500 | 200,000 | 36,513 | Jun 18, 2019, 05:26 PM |
| Iyengar Vijay K | EVP GPS, BD, & Licensing | May 09, 2019 | Option Exercise | $82.02 | 1,434 | 117,617 | 12,468 | May 10, 2019, 04:38 PM |
| Pasquale Maria E | EVP & General Counsel | Apr 09, 2019 | Option Exercise | $82.73 | 517 | 42,771 | 11,013 | Apr 11, 2019, 05:03 PM |
| BAKER BROS. ADVISORS LP | Director | Mar 29, 2019 | Option Exercise | $86.01 | 660 | 56,767 | 29,289,013 | Apr 02, 2019, 05:21 PM |
| Clancy Paul J | Director | Mar 29, 2019 | Option Exercise | $86.01 | 203 | 17,460 | 203 | Apr 02, 2019, 05:08 PM |
| SWAIN PAULA J | EVP, Human Resources | Apr 01, 2019 | Option Exercise | $18.32 | 10,000 | 183,200 | 44,731 | Apr 02, 2019, 04:51 PM |
| SWAIN PAULA J | EVP, Human Resources | Apr 01, 2019 | Sale | $87.01 | 10,000 | 870,100 | 36,513 | Apr 02, 2019, 04:51 PM |
| FOUSE JACQUALYN A | Director | Mar 29, 2019 | Option Exercise | $86.01 | 145 | 12,471 | 857 | Apr 02, 2019, 04:47 PM |
| DIXON WENDY L | Director | Mar 29, 2019 | Option Exercise | $86.01 | 188 | 16,170 | 10,387 | Apr 02, 2019, 04:44 PM |
| BROOKE PAUL A | Director | Mar 29, 2019 | Option Exercise | $86.01 | 276 | 23,739 | 199,205 | Apr 02, 2019, 04:31 PM |
| BIENAIME JEAN JACQUES | Director | Mar 29, 2019 | Option Exercise | $86.01 | 168 | 14,450 | 7,064 | Apr 02, 2019, 12:00 AM |
| SWAIN PAULA J | EVP, Human Resources | Mar 01, 2019 | Option Exercise | $18.32 | 10,000 | 183,200 | 46,513 | Mar 05, 2019, 12:00 AM |
| SWAIN PAULA J | EVP, Human Resources | Mar 01, 2019 | Sale | $86.68 | 10,000 | 866,800 | 36,513 | Mar 05, 2019, 12:00 AM |
| BAKER BROS. ADVISORS LP | Director | Feb 26, 2019 | Option Exercise | $2.80 | 40,000 | 112,000 | 29,288,793 | Feb 27, 2019, 05:19 PM |
| Stamoulis Christiana | EVP & Chief Financial Officer | Feb 11, 2019 | Option Exercise | $80.21 | 10,285 | 824,960 | 10,285 | Feb 13, 2019, 04:20 PM |
| SWAIN PAULA J | EVP, Human Resources | Feb 01, 2019 | Option Exercise | $18.32 | 10,000 | 183,200 | 41,124 | Feb 05, 2019, 04:36 PM |
| SWAIN PAULA J | EVP, Human Resources | Feb 01, 2019 | Sale | $81.19 | 10,000 | 811,900 | 31,124 | Feb 05, 2019, 04:36 PM |
| Flannelly Barry P | EVP & General Manager US | Jan 28, 2019 | Sale | $80.00 | 1,000 | 80,000 | 8,944 | Jan 30, 2019, 04:22 PM |
| Wenqing Yao | EVP, Head of Discovery Chem | Jan 17, 2019 | Option Exercise | $17.79 | 15,354 | 273,148 | 49,763 | Jan 22, 2019, 06:04 PM |
| Wenqing Yao | EVP, Head of Discovery Chem | Jan 17, 2019 | Sale | $77.61 | 15,354 | 1,191,624 | 34,409 | Jan 22, 2019, 06:04 PM |
| Trower Paul | Principal Accounting Officer | Jan 15, 2019 | Option Exercise | $17.79 | 5,813 | 103,413 | 19,713 | Jan 17, 2019, 04:15 PM |
| Trower Paul | Principal Accounting Officer | Jan 15, 2019 | Sale | $75.00 | 5,813 | 435,975 | 13,900 | Jan 17, 2019, 04:15 PM |
| Flannelly Barry P | EVP & General Manager US | Jan 08, 2019 | Sale | $75.56 | 1,714 | 129,510 | 9,944 | Jan 10, 2019, 04:11 PM |
| Wenqing Yao | EVP, Head of Discovery Chem | Jan 07, 2019 | Option Exercise | $74.21 | 808 | 59,962 | 34,409 | Jan 08, 2019, 04:46 PM |
| Wenqing Yao | EVP, Head of Discovery Chem | Jan 07, 2019 | Option Exercise | $17.79 | 10,000 | 177,900 | 45,217 | Jan 08, 2019, 04:46 PM |
| Wenqing Yao | EVP, Head of Discovery Chem | Jan 07, 2019 | Sale | $75.00 | 10,000 | 750,000 | 35,217 | Jan 08, 2019, 04:46 PM |
| Trower Paul | Principal Accounting Officer | Jan 07, 2019 | Option Exercise | $74.21 | 272 | 20,185 | 13,900 | Jan 08, 2019, 04:42 PM |
| Trower Paul | Principal Accounting Officer | Jan 07, 2019 | Option Exercise | $17.79 | 9,187 | 163,437 | 23,359 | Jan 08, 2019, 04:42 PM |
| Trower Paul | Principal Accounting Officer | Jan 07, 2019 | Sale | $75.00 | 9,187 | 689,025 | 14,172 | Jan 08, 2019, 04:42 PM |
| SWAIN PAULA J | EVP, Human Resources | Jan 07, 2019 | Option Exercise | $74.21 | 1,200 | 89,052 | 31,124 | Jan 08, 2019, 04:37 PM |
| SWAIN PAULA J | EVP, Human Resources | Jan 04, 2019 | Option Exercise | $18.32 | 30,000 | 549,600 | 62,324 | Jan 08, 2019, 04:37 PM |
| SWAIN PAULA J | EVP, Human Resources | Jan 04, 2019 | Sale | $70.00 | 30,000 | 2,100,000 | 32,324 | Jan 08, 2019, 04:37 PM |
| Stein Steven H | EVP & Chief Medical Officer | Jan 07, 2019 | Option Exercise | $74.21 | 847 | 62,856 | 13,773 | Jan 08, 2019, 04:32 PM |
| Hoppenot Herve | Chairman / CEO | Jan 07, 2019 | Option Exercise | $74.21 | 4,604 | 341,663 | 152,532 | Jan 08, 2019, 04:22 PM |
| Flannelly Barry P | EVP & General Manager US | Jan 07, 2019 | Option Exercise | $74.21 | 896 | 66,492 | 11,658 | Jan 08, 2019, 04:16 PM |
| Hoppenot Herve | Chairman / CEO | Jan 02, 2019 | Option Exercise | $63.56 | 27,630 | 1,756,163 | 157,136 | Jan 03, 2019, 04:20 PM |
| FOUSE JACQUALYN A | Director | Dec 31, 2018 | Option Exercise | $63.59 | 196 | 12,464 | 712 | Jan 03, 2019, 04:12 PM |
| BROOKE PAUL A | Director | Dec 31, 2018 | Option Exercise | $63.59 | 373 | 23,719 | 198,929 | Jan 03, 2019, 04:05 PM |
| BIENAIME JEAN JACQUES | Director | Dec 31, 2018 | Option Exercise | $63.59 | 228 | 14,499 | 6,896 | Jan 03, 2019, 04:02 PM |
| DIXON WENDY L | Director | Dec 31, 2018 | Option Exercise | $63.59 | 255 | 16,215 | 10,199 | Jan 03, 2019, 12:00 AM |
| BAKER BROS. ADVISORS LP | Director | Dec 31, 2018 | Option Exercise | $63.59 | 894 | 56,849 | 29,268,793 | Jan 02, 2019, 04:10 PM |
| BIENAIME JEAN JACQUES | Director | Nov 08, 2018 | Buy | $68.77 | 1,000 | 68,765 | 6,668 | Nov 09, 2018, 04:21 PM |
| Trower Paul | Principal Accounting Officer | Oct 03, 2018 | Option Exercise | $17.79 | 10,000 | 177,900 | 24,172 | Oct 05, 2018, 04:30 PM |
| Trower Paul | Principal Accounting Officer | Oct 03, 2018 | Sale | $70.00 | 10,000 | 700,000 | 14,172 | Oct 05, 2018, 04:30 PM |
| SWAIN PAULA J | EVP, Human Resources | Oct 03, 2018 | Option Exercise | $18.32 | 10,000 | 183,200 | 42,324 | Oct 05, 2018, 04:29 PM |
| SWAIN PAULA J | EVP, Human Resources | Oct 03, 2018 | Sale | $70.00 | 10,000 | 700,000 | 32,324 | Oct 05, 2018, 04:29 PM |
| Flannelly Barry P | EVP & General Manager US | Oct 03, 2018 | Sale | $70.00 | 1,000 | 70,000 | 12,427 | Oct 05, 2018, 04:23 PM |
| BAKER BROS. ADVISORS LP | Director | Sep 28, 2018 | Option Exercise | $69.08 | 825 | 56,991 | 29,268,495 | Oct 02, 2018, 05:06 PM |
| BROOKE PAUL A | Director | Sep 28, 2018 | Option Exercise | $69.08 | 343 | 23,694 | 198,556 | Oct 02, 2018, 04:27 PM |
| DIXON WENDY L | Director | Sep 28, 2018 | Option Exercise | $69.08 | 235 | 16,234 | 9,944 | Oct 02, 2018, 04:15 PM |
| BIENAIME JEAN JACQUES | Director | Sep 28, 2018 | Option Exercise | $69.08 | 209 | 14,438 | 5,668 | Oct 02, 2018, 04:11 PM |
| FOUSE JACQUALYN A | Director | Sep 28, 2018 | Option Exercise | $69.08 | 180 | 12,434 | 516 | Oct 02, 2018, 12:00 AM |
| SWAIN PAULA J | EVP, Human Resources | Sep 04, 2018 | Option Exercise | $18.32 | 10,000 | 183,200 | 42,324 | Sep 06, 2018, 04:30 PM |
| SWAIN PAULA J | EVP, Human Resources | Sep 04, 2018 | Sale | $73.21 | 10,000 | 732,100 | 32,324 | Sep 06, 2018, 04:30 PM |
| SWAIN PAULA J | EVP, Human Resources | Aug 21, 2018 | Option Exercise | $18.32 | 10,000 | 183,200 | 42,324 | Aug 22, 2018, 04:02 PM |
| SWAIN PAULA J | EVP, Human Resources | Aug 21, 2018 | Sale | $70.00 | 10,000 | 700,000 | 32,324 | Aug 22, 2018, 04:02 PM |
| Wenqing Yao | EVP, Head of Discovery Chem | Jul 16, 2018 | Option Exercise | $70.19 | 430 | 30,182 | 35,217 | Jul 18, 2018, 05:22 PM |
| Trower Paul | Principal Accounting Officer | Jul 16, 2018 | Option Exercise | $70.19 | 196 | 13,757 | 14,172 | Jul 18, 2018, 05:16 PM |
| SWAIN PAULA J | EVP, Human Resources | Jul 16, 2018 | Option Exercise | $70.19 | 639 | 44,851 | 32,324 | Jul 18, 2018, 05:12 PM |
| Stein Steven H | EVP & Chief Medical Officer | Jul 16, 2018 | Option Exercise | $70.19 | 577 | 40,500 | 14,620 | Jul 18, 2018, 05:06 PM |
| Huber Reid M | EVP, Chief Scientific Officer | Jul 16, 2018 | Option Exercise | $70.19 | 448 | 31,445 | 34,571 | Jul 18, 2018, 04:28 PM |
| Hoppenot Herve | Chairman / CEO | Jul 16, 2018 | Option Exercise | $70.19 | 2,359 | 165,578 | 184,766 | Jul 18, 2018, 04:25 PM |
| GRYSKA DAVID W | Executive Vice President, CFO | Jul 16, 2018 | Option Exercise | $70.19 | 455 | 31,936 | 10,235 | Jul 18, 2018, 04:12 PM |
| Flannelly Barry P | EVP & General Manager US | Jul 16, 2018 | Option Exercise | $70.19 | 430 | 30,182 | 13,427 | Jul 18, 2018, 04:09 PM |
| SWAIN PAULA J | EVP, Human Resources | Jul 09, 2018 | Option Exercise | $18.32 | 10,000 | 183,200 | 42,963 | Jul 11, 2018, 04:41 PM |
| SWAIN PAULA J | EVP, Human Resources | Jul 09, 2018 | Sale | $71.11 | 10,000 | 711,100 | 32,963 | Jul 11, 2018, 04:41 PM |
| Iyengar Vijay K | EVP GPS, BD, & Licensing | Jul 09, 2018 | Sale | $71.34 | 606 | 43,232 | 8,103 | Jul 11, 2018, 04:39 PM |
| Hoppenot Herve | Chairman / CEO | Jul 05, 2018 | Option Exercise | $68.28 | 1,532 | 104,605 | 187,125 | Jul 05, 2018, 05:18 PM |
| GRYSKA DAVID W | Executive Vice President, CFO | Jul 05, 2018 | Option Exercise | $68.28 | 280 | 19,118 | 10,690 | Jul 05, 2018, 05:12 PM |
| Huber Reid M | EVP, Chief Scientific Officer | Jul 05, 2018 | Option Exercise | $68.28 | 284 | 19,392 | 35,019 | Jul 05, 2018, 05:04 PM |
| Iyengar Vijay K | EVP GPS, BD, & Licensing | Jul 05, 2018 | Option Exercise | $68.28 | 273 | 18,640 | 8,709 | Jul 05, 2018, 04:58 PM |
| Flannelly Barry P | EVP & General Manager US | Jul 05, 2018 | Option Exercise | $68.28 | 273 | 18,640 | 13,857 | Jul 05, 2018, 04:49 PM |
| Stein Steven H | EVP & Chief Medical Officer | Jul 05, 2018 | Option Exercise | $68.28 | 262 | 17,889 | 15,197 | Jul 05, 2018, 04:45 PM |
| SWAIN PAULA J | EVP, Human Resources | Jul 05, 2018 | Option Exercise | $68.28 | 404 | 27,585 | 32,963 | Jul 05, 2018, 04:28 PM |
| Trower Paul | Principal Accounting Officer | Jul 05, 2018 | Option Exercise | $68.28 | 101 | 6,896 | 14,368 | Jul 05, 2018, 04:24 PM |
| Wenqing Yao | EVP, Head of Discovery Chem | Jul 05, 2018 | Option Exercise | $68.28 | 273 | 18,640 | 35,647 | Jul 05, 2018, 04:22 PM |
| BROOKE PAUL A | Director | Jun 29, 2018 | Option Exercise | $67.00 | 354 | 23,718 | 198,213 | Jul 03, 2018, 04:14 PM |
| BIENAIME JEAN JACQUES | Director | Jun 29, 2018 | Option Exercise | $67.00 | 216 | 14,472 | 5,459 | Jul 03, 2018, 04:08 PM |
| FOUSE JACQUALYN A | Director | Jun 29, 2018 | Option Exercise | $67.00 | 186 | 12,462 | 336 | Jul 03, 2018, 04:02 PM |
| BAKER BROS. ADVISORS LP | Director | Jun 29, 2018 | Option Exercise | $67.00 | 849 | 56,883 | 29,268,220 | Jul 03, 2018, 03:32 PM |
| DIXON WENDY L | Director | Jun 29, 2018 | Option Exercise | $67.00 | 242 | 16,214 | 9,709 | Jul 03, 2018, 12:00 AM |
| BROOKE PAUL A | Director | Jun 04, 2018 | Option Exercise | $2.80 | 20,000 | 56,000 | 217,859 | Jun 06, 2018, 04:33 PM |
| Hoppenot Herve | Chairman / CEO | May 02, 2018 | Buy | $60.94 | 15,000 | 914,100 | 276,690 | May 03, 2018, 05:05 PM |
| BAKER BROS. ADVISORS LP | Director | May 02, 2018 | Option Exercise | $9.92 | 60,000 | 595,200 | 29,267,937 | May 03, 2018, 04:19 PM |
| SWAIN PAULA J | EVP, Human Resources | Apr 30, 2018 | Option Exercise | $17.79 | 80,000 | 1,423,200 | 107,267 | May 02, 2018, 05:04 PM |
| SWAIN PAULA J | EVP, Human Resources | Apr 30, 2018 | Sale | $62.43 | 80,000 | 4,994,400 | 33,367 | May 02, 2018, 05:04 PM |
| BROOKE PAUL A | Director | Apr 05, 2018 | Option Exercise | $9.92 | 20,000 | 198,400 | 217,859 | Apr 09, 2018, 05:01 PM |
| BROOKE PAUL A | Director | Mar 29, 2018 | Option Exercise | $83.33 | 285 | 23,749 | 197,859 | Apr 03, 2018, 04:23 PM |
| FOUSE JACQUALYN A | Director | Mar 29, 2018 | Option Exercise | $83.33 | 150 | 12,500 | 150 | Apr 03, 2018, 12:00 AM |
| BIENAIME JEAN JACQUES | Director | Mar 29, 2018 | Option Exercise | $83.33 | 174 | 14,499 | 5,243 | Apr 03, 2018, 12:00 AM |
| DIXON WENDY L | Director | Mar 29, 2018 | Option Exercise | $83.33 | 195 | 16,249 | 9,467 | Apr 03, 2018, 12:00 AM |
| BAKER BROS. ADVISORS LP | Director | Mar 29, 2018 | Option Exercise | $83.33 | 684 | 56,998 | 29,247,937 | Apr 02, 2018, 05:59 PM |
| Stein Steven H | EVP & Chief Medical Officer | Mar 02, 2018 | Option Exercise | $86.61 | 2,081 | 180,235 | 15,459 | Mar 06, 2018, 04:30 PM |
| GRYSKA DAVID W | Executive Vice President, CFO | Feb 20, 2018 | Option Exercise | $86.03 | 1,070 | 92,052 | 12,922 | Feb 22, 2018, 04:46 PM |
| GRYSKA DAVID W | Executive Vice President, CFO | Feb 21, 2018 | Sale | $85.56 | 1,952 | 167,013 | 10,970 | Feb 22, 2018, 04:46 PM |
| Wenqing Yao | EVP, Head of Discovery Chem | Feb 20, 2018 | Option Exercise | $86.03 | 1,026 | 88,267 | 35,584 | Feb 22, 2018, 04:29 PM |
| Huber Reid M | EVP, Chief Scientific Officer | Feb 20, 2018 | Option Exercise | $86.03 | 1,064 | 91,536 | 37,141 | Feb 22, 2018, 04:23 PM |
| Huber Reid M | EVP, Chief Scientific Officer | Feb 21, 2018 | Sale | $85.55 | 1,958 | 167,507 | 35,183 | Feb 22, 2018, 04:23 PM |
| Trower Paul | Principal Accounting Officer | Feb 20, 2018 | Option Exercise | $86.03 | 414 | 35,616 | 11,439 | Feb 22, 2018, 04:18 PM |
| SWAIN PAULA J | EVP, Human Resources | Feb 20, 2018 | Option Exercise | $86.03 | 1,026 | 88,267 | 33,367 | Feb 22, 2018, 04:15 PM |
| Hoppenot Herve | Chairman / CEO | Feb 20, 2018 | Option Exercise | $86.03 | 37,314 | 3,210,123 | 261,690 | Feb 22, 2018, 04:12 PM |
| Flannelly Barry P | EVP & General Manager US | Feb 20, 2018 | Option Exercise | $86.03 | 1,026 | 88,267 | 13,823 | Feb 22, 2018, 04:10 PM |
| GRYSKA DAVID W | Executive Vice President, CFO | Jan 05, 2018 | Option Exercise | $83.83 | 6,760 | 566,691 | 20,752 | Jan 09, 2018, 04:09 PM |
| GRYSKA DAVID W | Executive Vice President, CFO | Jan 05, 2018 | Sale | $98.87 | 6,760 | 668,361 | 13,992 | Jan 09, 2018, 04:09 PM |
| DIXON WENDY L | Director | Dec 29, 2017 | Option Exercise | $94.71 | 171 | 16,195 | 9,272 | Jan 03, 2018, 04:12 PM |
| BROOKE PAUL A | Director | Dec 29, 2017 | Option Exercise | $94.71 | 250 | 23,677 | 197,574 | Jan 03, 2018, 04:09 PM |
| BAKER BROS. ADVISORS LP | Director | Dec 29, 2017 | Option Exercise | $94.71 | 600 | 56,826 | 29,247,709 | Jan 03, 2018, 04:05 PM |
| BIENAIME JEAN JACQUES | Director | Dec 29, 2017 | Option Exercise | $94.71 | 153 | 14,491 | 5,069 | Jan 03, 2018, 12:00 AM |
| Iyengar Vijay K | EVP GPS, BD, & Licensing | Jan 02, 2018 | Option Exercise | $72.86 | 5,000 | 364,300 | 13,676 | Jan 03, 2018, 12:00 AM |
| Iyengar Vijay K | EVP GPS, BD, & Licensing | Jan 02, 2018 | Sale | $97.26 | 5,000 | 486,300 | 8,676 | Jan 03, 2018, 12:00 AM |
| Huber Reid M | EVP, Chief Scientific Officer | Dec 01, 2017 | Sale | $98.01 | 696 | 68,215 | 38,205 | Dec 05, 2017, 04:01 PM |
| FRIEDMAN PAUL A | Director | Nov 16, 2017 | Sale | $105.24 | 28,507 | 3,000,077 | 269,011 | Nov 20, 2017, 04:25 PM |
| GRYSKA DAVID W | Executive Vice President, CFO | Nov 01, 2017 | Option Exercise | $107.96 | 3,913 | 422,447 | 17,907 | Nov 03, 2017, 04:01 PM |
| GRYSKA DAVID W | Executive Vice President, CFO | Nov 02, 2017 | Sale | $105.63 | 3,915 | 413,541 | 13,992 | Nov 03, 2017, 04:01 PM |
| BAKER BROS. ADVISORS LP | Director | Sep 29, 2017 | Option Exercise | $116.74 | 486 | 56,736 | 29,247,509 | Oct 03, 2017, 05:30 PM |
| DIXON WENDY L | Director | Sep 29, 2017 | Option Exercise | $116.74 | 139 | 16,227 | 9,101 | Oct 03, 2017, 04:29 PM |
| BIENAIME JEAN JACQUES | Director | Sep 29, 2017 | Option Exercise | $116.74 | 124 | 14,476 | 4,916 | Oct 03, 2017, 04:13 PM |
| BROOKE PAUL A | Director | Sep 29, 2017 | Option Exercise | $116.74 | 203 | 23,698 | 197,324 | Oct 03, 2017, 12:00 AM |
| Hoppenot Herve | Chairman / CEO | Sep 18, 2017 | Sale | $119.45 | 70,502 | 8,421,464 | 299,004 | Sep 20, 2017, 04:28 PM |
| Wenqing Yao | EVP, Head of Discovery Chem | Sep 13, 2017 | Option Exercise | $123.15 | 674 | 83,003 | 36,610 | Sep 15, 2017, 04:39 PM |
| SWAIN PAULA J | EVP, Human Resources | Sep 13, 2017 | Option Exercise | $123.15 | 674 | 83,003 | 34,393 | Sep 15, 2017, 04:35 PM |
| Stein Steven H | EVP & Chief Medical Officer | Sep 13, 2017 | Option Exercise | $123.15 | 625 | 76,969 | 17,540 | Sep 15, 2017, 04:31 PM |
| Siegel Eric H. | EVP, General Counsel | Sep 13, 2017 | Option Exercise | $123.15 | 680 | 83,742 | 21,053 | Sep 15, 2017, 04:28 PM |
| Huber Reid M | EVP, Chief Scientific Officer | Sep 13, 2017 | Option Exercise | $123.15 | 692 | 85,220 | 38,862 | Sep 15, 2017, 04:24 PM |
| Hoppenot Herve | Chairman / CEO | Sep 13, 2017 | Option Exercise | $123.15 | 2,486 | 306,151 | 369,506 | Sep 15, 2017, 04:19 PM |
| GRYSKA DAVID W | Executive Vice President, CFO | Sep 13, 2017 | Option Exercise | $123.15 | 712 | 87,683 | 21,820 | Sep 15, 2017, 04:14 PM |
| Flannelly Barry P | EVP & General Manager US | Sep 13, 2017 | Option Exercise | $123.15 | 674 | 83,003 | 15,496 | Sep 15, 2017, 04:11 PM |
| Flannelly Barry P | EVP & General Manager US | Sep 14, 2017 | Sale | $124.25 | 714 | 88,715 | 14,782 | Sep 15, 2017, 04:11 PM |
| BAKER BROS. ADVISORS LP | Director | Sep 08, 2017 | Buy | $132.00 | 100,000 | 13,200,000 | 29,247,347 | Sep 08, 2017, 05:06 PM |
| Trower Paul | Principal Accounting Officer | Sep 05, 2017 | Option Exercise | $17.79 | 3,000 | 53,370 | 14,853 | Sep 07, 2017, 04:04 PM |
| Trower Paul | Principal Accounting Officer | Sep 05, 2017 | Sale | $138.41 | 3,000 | 415,230 | 11,853 | Sep 07, 2017, 04:04 PM |
| Siegel Eric H. | EVP, General Counsel | Sep 01, 2017 | Option Exercise | $64.55 | 1,820 | 117,481 | 23,553 | Sep 05, 2017, 04:27 PM |
| Siegel Eric H. | EVP, General Counsel | Sep 01, 2017 | Sale | $137.40 | 1,820 | 250,068 | 21,733 | Sep 05, 2017, 04:27 PM |
| SWAIN PAULA J | EVP, Human Resources | Aug 31, 2017 | Option Exercise | $17.79 | 20,000 | 355,800 | 55,067 | Sep 05, 2017, 04:22 PM |
| SWAIN PAULA J | EVP, Human Resources | Aug 31, 2017 | Sale | $140.00 | 20,000 | 2,800,000 | 35,067 | Sep 05, 2017, 04:22 PM |
| Stein Steven H | EVP & Chief Medical Officer | Aug 29, 2017 | Option Exercise | $89.52 | 2,111 | 188,974 | 20,276 | Aug 31, 2017, 04:13 PM |
| Stein Steven H | EVP & Chief Medical Officer | Aug 29, 2017 | Sale | $125.00 | 2,111 | 263,875 | 19,754 | Aug 31, 2017, 04:13 PM |
| Trower Paul | Principal Accounting Officer | Aug 03, 2017 | Option Exercise | $125.98 | 295 | 37,164 | 11,853 | Aug 07, 2017, 04:33 PM |
| Trower Paul | Principal Accounting Officer | Aug 04, 2017 | Option Exercise | $17.79 | 3,000 | 53,370 | 14,853 | Aug 07, 2017, 04:33 PM |
| Trower Paul | Principal Accounting Officer | Aug 04, 2017 | Sale | $125.25 | 3,000 | 375,750 | 11,853 | Aug 07, 2017, 04:33 PM |
| Siegel Eric H. | EVP, General Counsel | Aug 01, 2017 | Option Exercise | $64.55 | 1,820 | 117,481 | 23,553 | Aug 03, 2017, 04:54 PM |
| Siegel Eric H. | EVP, General Counsel | Aug 01, 2017 | Sale | $132.92 | 1,820 | 241,914 | 21,733 | Aug 03, 2017, 04:54 PM |
| Stein Steven H | EVP & Chief Medical Officer | Jul 20, 2017 | Option Exercise | $85.68 | 6,485 | 555,641 | 24,650 | Jul 21, 2017, 04:01 PM |
| Stein Steven H | EVP & Chief Medical Officer | Jul 20, 2017 | Sale | $131.09 | 6,485 | 850,119 | 23,459 | Jul 21, 2017, 04:01 PM |
| Trower Paul | Principal Accounting Officer | Jul 05, 2017 | Option Exercise | $17.79 | 3,000 | 53,370 | 15,148 | Jul 07, 2017, 05:02 PM |
| Trower Paul | Principal Accounting Officer | Jul 05, 2017 | Sale | $126.18 | 3,000 | 378,540 | 12,148 | Jul 07, 2017, 05:02 PM |
| Siegel Eric H. | EVP, General Counsel | Jul 03, 2017 | Option Exercise | $64.55 | 1,820 | 117,481 | 20,036 | Jul 05, 2017, 06:20 PM |
| Siegel Eric H. | EVP, General Counsel | Jul 03, 2017 | Sale | $126.20 | 1,820 | 229,684 | 18,216 | Jul 05, 2017, 06:20 PM |
| BAKER BROS. ADVISORS LP | Director | Jun 30, 2017 | Option Exercise | $125.91 | 450 | 56,660 | 29,161,945 | Jul 05, 2017, 06:01 PM |
| BIENAIME JEAN JACQUES | Director | Jun 30, 2017 | Option Exercise | $125.91 | 115 | 14,480 | 4,792 | Jul 05, 2017, 04:17 PM |
| GRYSKA DAVID W | Executive Vice President, CFO | Jun 30, 2017 | Option Exercise | $73.21 | 599 | 43,853 | 19,614 | Jul 05, 2017, 04:12 PM |
| GRYSKA DAVID W | Executive Vice President, CFO | Jun 30, 2017 | Sale | $129.74 | 599 | 77,714 | 19,015 | Jul 05, 2017, 04:12 PM |
| DIXON WENDY L | Director | Jun 30, 2017 | Option Exercise | $125.91 | 129 | 16,242 | 8,962 | Jul 05, 2017, 12:00 AM |
| BROOKE PAUL A | Director | Jun 30, 2017 | Option Exercise | $125.91 | 188 | 23,671 | 197,121 | Jul 05, 2017, 12:00 AM |
| Stein Steven H | EVP & Chief Medical Officer | Jun 20, 2017 | Option Exercise | $91.45 | 9,883 | 903,824 | 24,531 | Jun 22, 2017, 04:29 PM |
| Stein Steven H | EVP & Chief Medical Officer | Jun 20, 2017 | Sale | $125.00 | 9,883 | 1,235,375 | 20,661 | Jun 22, 2017, 04:29 PM |
| GRYSKA DAVID W | Executive Vice President, CFO | Jun 12, 2017 | Option Exercise | $73.21 | 16,756 | 1,226,707 | 35,771 | Jun 14, 2017, 04:50 PM |
| GRYSKA DAVID W | Executive Vice President, CFO | Jun 12, 2017 | Sale | $116.60 | 16,756 | 1,953,750 | 19,015 | Jun 14, 2017, 04:50 PM |
| Siegel Eric H. | EVP, General Counsel | Jun 06, 2017 | Option Exercise | $66.66 | 1,292 | 86,127 | 18,216 | Jun 07, 2017, 04:21 PM |
| Trower Paul | Principal Accounting Officer | Jun 05, 2017 | Option Exercise | $17.79 | 3,000 | 53,370 | 13,950 | Jun 07, 2017, 04:12 PM |
| Trower Paul | Principal Accounting Officer | Jun 05, 2017 | Sale | $132.50 | 3,000 | 397,500 | 10,950 | Jun 07, 2017, 04:12 PM |
| Siegel Eric H. | EVP, General Counsel | Jun 01, 2017 | Option Exercise | $64.55 | 1,820 | 117,481 | 18,744 | Jun 02, 2017, 04:22 PM |
| Siegel Eric H. | EVP, General Counsel | Jun 01, 2017 | Sale | $130.00 | 1,820 | 236,600 | 16,924 | Jun 02, 2017, 04:22 PM |
| BIENAIME JEAN JACQUES | Director | May 31, 2017 | Buy | $131.80 | 500 | 65,900 | 4,677 | Jun 02, 2017, 04:14 PM |
| BIENAIME JEAN JACQUES | Director | May 15, 2017 | Buy | $115.00 | 500 | 57,500 | 4,177 | May 17, 2017, 04:18 PM |
| Huber Reid M | EVP, Chief Scientific Officer | May 05, 2017 | Option Exercise | $125.00 | 7,732 | 966,500 | 44,614 | May 09, 2017, 04:38 PM |
| Huber Reid M | EVP, Chief Scientific Officer | May 08, 2017 | Sale | $119.21 | 8,577 | 1,022,464 | 36,037 | May 09, 2017, 04:38 PM |
| Wenqing Yao | EVP, Head of Discovery Chem | May 05, 2017 | Option Exercise | $125.00 | 4,413 | 551,625 | 33,767 | May 09, 2017, 04:33 PM |
| Trower Paul | Principal Accounting Officer | May 05, 2017 | Option Exercise | $17.79 | 3,000 | 53,370 | 13,950 | May 09, 2017, 04:17 PM |
| Trower Paul | Principal Accounting Officer | May 05, 2017 | Sale | $121.70 | 3,000 | 365,100 | 10,950 | May 09, 2017, 04:17 PM |
| Flannelly Barry P | EVP & General Manager US | May 01, 2017 | Option Exercise | $48.44 | 2,064 | 99,980 | 17,949 | May 02, 2017, 06:01 PM |
| Flannelly Barry P | EVP & General Manager US | May 01, 2017 | Sale | $124.73 | 5,296 | 660,564 | 17,146 | May 02, 2017, 06:01 PM |
| Siegel Eric H. | EVP, General Counsel | May 01, 2017 | Option Exercise | $64.55 | 1,820 | 117,481 | 18,744 | May 02, 2017, 05:52 PM |
| Siegel Eric H. | EVP, General Counsel | May 01, 2017 | Sale | $124.73 | 1,820 | 227,009 | 16,924 | May 02, 2017, 05:52 PM |
| GRYSKA DAVID W | Executive Vice President, CFO | Apr 28, 2017 | Option Exercise | $67.06 | 1,389 | 93,146 | 20,404 | May 02, 2017, 05:39 PM |
| GRYSKA DAVID W | Executive Vice President, CFO | Apr 28, 2017 | Sale | $124.26 | 1,389 | 172,597 | 19,015 | May 02, 2017, 05:39 PM |
| BIENAIME JEAN JACQUES | Director | Apr 28, 2017 | Buy | $124.26 | 500 | 62,130 | 3,677 | May 02, 2017, 04:31 PM |
| BAKER BROS. ADVISORS LP | Director | Apr 27, 2017 | Option Exercise | $7.26 | 60,000 | 435,600 | 29,161,795 | Apr 28, 2017, 05:10 PM |
| BIENAIME JEAN JACQUES | Director | Apr 13, 2017 | Buy | $139.66 | 1,000 | 139,660 | 3,177 | Apr 17, 2017, 04:56 PM |
| Stein Steven H | EVP & Chief Medical Officer | Apr 07, 2017 | Option Exercise | $89.79 | 32,000 | 2,873,160 | 46,648 | Apr 11, 2017, 04:24 PM |
| Stein Steven H | EVP & Chief Medical Officer | Apr 07, 2017 | Sale | $137.88 | 32,000 | 4,412,310 | 19,648 | Apr 11, 2017, 04:24 PM |
| Siegel Eric H. | EVP, General Counsel | Apr 10, 2017 | Option Exercise | $39.13 | 4,043 | 158,206 | 20,828 | Apr 11, 2017, 04:19 PM |
| Siegel Eric H. | EVP, General Counsel | Apr 10, 2017 | Sale | $140.18 | 4,043 | 566,748 | 18,605 | Apr 11, 2017, 04:19 PM |
| GRYSKA DAVID W | Executive Vice President, CFO | Apr 10, 2017 | Option Exercise | $67.06 | 41,528 | 2,784,868 | 60,543 | Apr 11, 2017, 04:14 PM |
| GRYSKA DAVID W | Executive Vice President, CFO | Apr 10, 2017 | Sale | $138.00 | 41,528 | 5,730,864 | 58,804 | Apr 11, 2017, 04:14 PM |
| BIENAIME JEAN JACQUES | Director | Apr 07, 2017 | Buy | $139.48 | 1,000 | 139,480 | 2,177 | Apr 11, 2017, 04:06 PM |
| BAKER BROS. ADVISORS LP | Director | Mar 31, 2017 | Option Exercise | $133.67 | 426 | 56,943 | 29,141,795 | Apr 04, 2017, 07:33 PM |
| DIXON WENDY L | Director | Mar 31, 2017 | Option Exercise | $133.67 | 121 | 16,174 | 8,833 | Mar 31, 2017, 05:21 PM |
| BROOKE PAUL A | Director | Mar 31, 2017 | Option Exercise | $133.67 | 177 | 23,660 | 196,933 | Mar 31, 2017, 05:10 PM |
| BIENAIME JEAN JACQUES | Director | Mar 31, 2017 | Option Exercise | $133.67 | 108 | 14,436 | 1,177 | Mar 31, 2017, 05:06 PM |
| BROOKE PAUL A | Director | Mar 17, 2017 | Option Exercise | $7.26 | 20,000 | 145,200 | 216,756 | Mar 20, 2017, 04:14 PM |
| BROOKE PAUL A | Director | Mar 17, 2017 | Sale | $147.75 | 20,000 | 2,955,000 | 196,756 | Mar 20, 2017, 04:14 PM |
| FRIEDMAN PAUL A | Director | Mar 16, 2017 | Option Exercise | $18.32 | 8,307 | 152,184 | 305,825 | Mar 20, 2017, 04:10 PM |
| FRIEDMAN PAUL A | Director | Mar 17, 2017 | Option Exercise | $18.32 | 41,693 | 763,816 | 339,211 | Mar 20, 2017, 04:10 PM |
| FRIEDMAN PAUL A | Director | Mar 16, 2017 | Sale | $151.45 | 8,307 | 1,258,095 | 297,518 | Mar 20, 2017, 04:10 PM |
| FRIEDMAN PAUL A | Director | Mar 17, 2017 | Sale | $148.18 | 41,693 | 6,178,068 | 297,518 | Mar 20, 2017, 04:10 PM |
| Huber Reid M | EVP, Chief Scientific Officer | Feb 27, 2017 | Sale | $131.88 | 2,008 | 264,815 | 52,262 | Mar 01, 2017, 04:56 PM |
| Hoppenot Herve | Chairman / CEO | Feb 24, 2017 | Option Exercise | $121.95 | 40,921 | 4,990,316 | 390,756 | Feb 28, 2017, 05:02 PM |
| Huber Reid M | EVP, Chief Scientific Officer | Feb 24, 2016 | Option Exercise | $121.95 | 1,090 | 132,925 | 54,270 | Feb 28, 2017, 04:56 PM |
| Siegel Eric H. | EVP, General Counsel | Feb 24, 2017 | Option Exercise | $121.95 | 1,286 | 156,828 | 16,785 | Feb 28, 2017, 04:51 PM |
| Flannelly Barry P | EVP & General Manager US | Feb 24, 2017 | Option Exercise | $121.95 | 2,473 | 301,582 | 15,743 | Feb 28, 2017, 04:48 PM |
| Wenqing Yao | EVP, Head of Discovery Chem | Feb 24, 2017 | Option Exercise | $121.95 | 788 | 96,097 | 37,843 | Feb 28, 2017, 04:43 PM |
| SWAIN PAULA J | EVP, Human Resources | Feb 24, 2017 | Option Exercise | $121.95 | 1,182 | 144,145 | 31,550 | Feb 28, 2017, 04:39 PM |
| FRIEDMAN PAUL A | Director | Feb 23, 2017 | Option Exercise | $18.32 | 50,000 | 916,000 | 347,518 | Feb 27, 2017, 04:54 PM |
| FRIEDMAN PAUL A | Director | Feb 23, 2017 | Sale | $120.32 | 50,000 | 6,016,000 | 297,518 | Feb 27, 2017, 04:54 PM |
| Huber Reid M | EVP, Chief Scientific Officer | Jan 09, 2017 | Sale | $113.55 | 11,739 | 1,332,963 | 52,185 | Jan 11, 2017, 04:21 PM |
| BAKER JULIAN | Director | Dec 30, 2016 | Option Exercise | $100.27 | 567 | 56,853 | 19,758,174 | Jan 04, 2017, 06:01 PM |
| DIXON WENDY L | Director | Dec 30, 2016 | Option Exercise | $100.27 | 162 | 16,244 | 8,712 | Dec 30, 2016, 05:13 PM |
| BROOKE PAUL A | Director | Dec 30, 2016 | Option Exercise | $100.27 | 236 | 23,664 | 196,756 | Dec 30, 2016, 05:10 PM |
| BIENAIME JEAN JACQUES | Director | Dec 30, 2016 | Option Exercise | $100.27 | 144 | 14,439 | 1,069 | Dec 30, 2016, 05:07 PM |
| SWAIN PAULA J | EVP, Human Resources | Nov 15, 2016 | Option Exercise | $14.72 | 10,000 | 147,200 | 39,248 | Nov 17, 2016, 04:29 PM |
| SWAIN PAULA J | EVP, Human Resources | Nov 15, 2016 | Sale | $103.26 | 10,000 | 1,032,600 | 29,248 | Nov 17, 2016, 04:29 PM |
| Huber Reid M | EVP, Chief Scientific Officer | Nov 09, 2016 | Sale | $109.95 | 2,715 | 298,514 | 63,924 | Nov 10, 2016, 04:34 PM |
| SWAIN PAULA J | EVP, Human Resources | Oct 20, 2016 | Option Exercise | $14.72 | 10,000 | 147,200 | 39,248 | Oct 24, 2016, 04:44 PM |
| SWAIN PAULA J | EVP, Human Resources | Oct 20, 2016 | Sale | $90.00 | 10,000 | 900,000 | 29,248 | Oct 24, 2016, 04:44 PM |
| Huber Reid M | EVP, Chief Scientific Officer | Oct 07, 2016 | Option Exercise | $18.32 | 11,709 | 214,509 | 78,310 | Oct 11, 2016, 04:37 PM |
| Huber Reid M | EVP, Chief Scientific Officer | Oct 07, 2016 | Sale | $96.40 | 11,709 | 1,128,748 | 66,601 | Oct 11, 2016, 04:37 PM |
| Flannelly Barry P | EVP & General Manager US | Oct 07, 2016 | Option Exercise | $48.44 | 24,204 | 1,172,442 | 35,391 | Oct 11, 2016, 04:33 PM |
| Flannelly Barry P | EVP & General Manager US | Oct 07, 2016 | Sale | $97.00 | 24,204 | 2,347,788 | 11,187 | Oct 11, 2016, 04:33 PM |
| BAKER JULIAN | Director | Sep 30, 2016 | Option Exercise | $94.29 | 603 | 56,857 | 19,757,985 | Oct 04, 2016, 06:33 PM |
| BROOKE PAUL A | Director | Sep 30, 2016 | Option Exercise | $94.29 | 251 | 23,667 | 196,520 | Oct 04, 2016, 04:41 PM |
| BIENAIME JEAN JACQUES | Director | Sep 30, 2016 | Option Exercise | $94.29 | 153 | 14,426 | 925 | Oct 04, 2016, 04:39 PM |
| SWAIN PAULA J | EVP, Human Resources | Sep 23, 2016 | Option Exercise | $14.72 | 20,000 | 294,400 | 49,248 | Sep 26, 2016, 04:34 PM |
| SWAIN PAULA J | EVP, Human Resources | Sep 23, 2016 | Sale | $90.00 | 20,000 | 1,800,000 | 29,248 | Sep 26, 2016, 04:34 PM |
| Huber Reid M | EVP, Chief Scientific Officer | Aug 02, 2016 | Sale | $87.96 | 10,000 | 879,600 | 66,601 | Aug 02, 2016, 05:09 PM |
| SWAIN PAULA J | EVP, Human Resources | Jul 29, 2016 | Option Exercise | $14.72 | 60,000 | 883,200 | 89,248 | Aug 02, 2016, 04:54 PM |
| SWAIN PAULA J | EVP, Human Resources | Jul 29, 2016 | Sale | $90.00 | 60,000 | 5,400,000 | 29,248 | Aug 02, 2016, 04:54 PM |
| BAKER JULIAN | Director | Jun 30, 2016 | Option Exercise | $79.98 | 711 | 56,866 | 19,757,784 | Jul 05, 2016, 05:13 PM |
| DIXON WENDY L | Director | Jun 30, 2016 | Option Exercise | $79.98 | 203 | 16,236 | 8,378 | Jul 05, 2016, 04:32 PM |
| BROOKE PAUL A | Director | Jun 30, 2016 | Option Exercise | $79.98 | 296 | 23,674 | 196,269 | Jul 05, 2016, 04:31 PM |
| BIENAIME JEAN JACQUES | Director | Jun 30, 2016 | Option Exercise | $79.98 | 181 | 14,476 | 772 | Jul 05, 2016, 04:31 PM |
| BROOKE PAUL A | Director | Apr 01, 2016 | Option Exercise | $3.86 | 20,000 | 77,200 | 195,973 | Apr 05, 2016, 04:30 PM |
| BAKER JULIAN | Director | Mar 31, 2016 | Option Exercise | $72.47 | 786 | 56,961 | 19,757,547 | Apr 04, 2016, 06:32 PM |
| DIXON WENDY L | Director | Mar 31, 2016 | Option Exercise | $72.47 | 224 | 16,233 | 8,175 | Apr 01, 2016, 04:11 PM |
| BROOKE PAUL A | Director | Mar 31, 2016 | Option Exercise | $72.47 | 327 | 23,698 | 175,973 | Apr 01, 2016, 04:11 PM |
| BIENAIME JEAN JACQUES | Director | Mar 31, 2016 | Option Exercise | $72.47 | 200 | 14,494 | 591 | Apr 01, 2016, 04:10 PM |
| BAKER JULIAN | Director | Mar 17, 2016 | Option Exercise | $3.86 | 60,000 | 231,600 | 19,396,568 | Mar 17, 2016, 07:14 PM |
| BAKER JULIAN | Director | Mar 17, 2016 | Buy | $61.49 | 400,000 | 24,595,777 | 19,757,285 | Mar 17, 2016, 07:14 PM |
| BAKER JULIAN | Director | Mar 15, 2016 | Buy | $66.47 | 400,000 | 26,588,417 | 19,376,568 | Mar 17, 2016, 07:14 PM |
| Wenqing Yao | EVP, Discovery Medicinal and P | Feb 25, 2016 | Option Exercise | $18.32 | 6,566 | 120,289 | 30,547 | Feb 29, 2016, 04:28 PM |
| BAKER JULIAN | Director | Feb 25, 2016 | Buy | $74.00 | 6,700 | 495,800 | 19,015,852 | Feb 26, 2016, 04:42 PM |
| BAKER JULIAN | Director | Feb 24, 2016 | Buy | $70.41 | 57,590 | 4,055,187 | 19,009,830 | Feb 26, 2016, 04:42 PM |
| Huber Reid M | EVP, Chief Scientific Officer | Feb 16, 2016 | Option Exercise | $18.32 | 5,377 | 98,507 | 71,046 | Feb 18, 2016, 04:31 PM |
| BAKER JULIAN | Director | Feb 12, 2016 | Buy | $67.14 | 208,677 | 14,010,425 | 18,346,124 | Feb 16, 2016, 08:14 PM |
| BAKER JULIAN | Director | Feb 16, 2016 | Buy | $70.71 | 678,488 | 47,973,375 | 18,958,070 | Feb 16, 2016, 08:14 PM |
| BAKER JULIAN | Director | Feb 12, 2016 | Buy | $65.83 | 922,530 | 60,732,037 | 18,158,080 | Feb 16, 2016, 08:13 PM |
| BAKER JULIAN | Director | Feb 11, 2016 | Buy | $61.93 | 1,328,897 | 82,297,659 | 17,326,770 | Feb 16, 2016, 08:13 PM |
| SWAIN PAULA J | EVP, Human Resources | Jan 15, 2016 | Option Exercise | $3.11 | 13,531 | 42,081 | 37,224 | Jan 20, 2016, 04:31 PM |
| SWAIN PAULA J | EVP, Human Resources | Jan 15, 2016 | Sale | $76.96 | 13,531 | 1,041,346 | 23,693 | Jan 20, 2016, 04:31 PM |
| Siegel Eric H. | EVP, General Counsel | Jan 15, 2016 | Option Exercise | $18.32 | 2,509 | 45,965 | 8,829 | Jan 20, 2016, 04:30 PM |
| Levy Richard S | EVP, Chief Drug Dev Officer | Jan 06, 2016 | Option Exercise | $18.32 | 3,937 | 72,126 | 20,863 | Jan 08, 2016, 04:37 PM |
| Levy Richard S | EVP, Chief Drug Dev Officer | Jan 06, 2016 | Sale | $101.86 | 3,937 | 401,023 | 16,926 | Jan 08, 2016, 04:37 PM |
| BAKER JULIAN | Director | Dec 31, 2015 | Option Exercise | $108.45 | 525 | 56,936 | 16,129,274 | Jan 05, 2016, 06:22 PM |
| Hoppenot Herve | Chairman / CEO | Dec 31, 2015 | Option Exercise | $109.11 | 32,297 | 3,523,926 | 349,761 | Dec 31, 2015, 04:31 PM |
| BROOKE PAUL A | Director | Dec 31, 2015 | Option Exercise | $108.45 | 218 | 23,642 | 175,466 | Dec 31, 2015, 04:30 PM |
| DIXON WENDY L | Director | Dec 31, 2015 | Option Exercise | $108.45 | 149 | 16,159 | 7,951 | Dec 31, 2015, 04:29 PM |
| BIENAIME JEAN JACQUES | Director | Dec 31, 2015 | Option Exercise | $108.45 | 133 | 14,424 | 391 | Dec 31, 2015, 04:28 PM |
| Siegel Eric H. | EVP, General Counsel | Dec 10, 2015 | Option Exercise | $18.32 | 1,936 | 35,468 | 5,646 | Dec 14, 2015, 04:32 PM |
| Siegel Eric H. | EVP, General Counsel | Dec 10, 2015 | Sale | $107.96 | 1,936 | 209,011 | 3,710 | Dec 14, 2015, 04:32 PM |
| Levy Richard S | EVP, Chief Drug Dev Officer | Dec 07, 2015 | Option Exercise | $18.32 | 3,937 | 72,126 | 20,863 | Dec 09, 2015, 04:31 PM |
| Levy Richard S | EVP, Chief Drug Dev Officer | Dec 07, 2015 | Sale | $106.18 | 3,937 | 418,031 | 16,926 | Dec 09, 2015, 04:31 PM |
| FRIEDMAN PAUL A | Director | Nov 18, 2015 | Option Exercise | $17.79 | 125,000 | 2,223,750 | 422,518 | Nov 19, 2015, 05:51 PM |
| FRIEDMAN PAUL A | Director | Nov 17, 2015 | Option Exercise | $17.79 | 100,000 | 1,779,000 | 397,518 | Nov 19, 2015, 05:51 PM |
| FRIEDMAN PAUL A | Director | Nov 18, 2015 | Sale | $115.33 | 125,000 | 14,415,840 | 336,386 | Nov 19, 2015, 05:51 PM |
| FRIEDMAN PAUL A | Director | Nov 17, 2015 | Sale | $111.96 | 100,000 | 11,196,269 | 390,466 | Nov 19, 2015, 05:51 PM |
| Siegel Eric H. | EVP, General Counsel | Nov 10, 2015 | Option Exercise | $18.32 | 2,222 | 40,707 | 5,932 | Nov 12, 2015, 04:30 PM |
| Siegel Eric H. | EVP, General Counsel | Nov 10, 2015 | Sale | $104.86 | 2,222 | 232,999 | 3,710 | Nov 12, 2015, 04:30 PM |
| Levy Richard S | EVP, Chief Drug Dev Officer | Nov 06, 2015 | Option Exercise | $18.32 | 3,936 | 72,108 | 20,862 | Nov 10, 2015, 08:21 PM |
| Levy Richard S | EVP, Chief Drug Dev Officer | Nov 06, 2015 | Sale | $116.51 | 3,936 | 458,583 | 16,926 | Nov 10, 2015, 08:21 PM |
| Wenqing Yao | EVP, Discovery Medicinal and P | Nov 03, 2015 | Option Exercise | $17.79 | 5,000 | 88,950 | 26,371 | Nov 05, 2015, 04:47 PM |
| Wenqing Yao | EVP, Discovery Medicinal and P | Nov 03, 2015 | Sale | $124.78 | 5,786 | 721,961 | 21,371 | Nov 05, 2015, 04:47 PM |
| Siegel Eric H. | EVP, General Counsel | Oct 13, 2015 | Option Exercise | $18.32 | 2,222 | 40,707 | 5,577 | Oct 15, 2015, 04:30 PM |
| Siegel Eric H. | EVP, General Counsel | Oct 13, 2015 | Sale | $101.49 | 2,222 | 225,511 | 3,355 | Oct 15, 2015, 04:30 PM |
| Levy Richard S | EVP, Chief Drug Dev Officer | Oct 06, 2015 | Option Exercise | $18.32 | 3,937 | 72,126 | 20,863 | Oct 08, 2015, 04:28 PM |
| Levy Richard S | EVP, Chief Drug Dev Officer | Oct 06, 2015 | Sale | $122.29 | 3,937 | 481,456 | 16,926 | Oct 08, 2015, 04:28 PM |
| BAKER JULIAN | Director | Oct 01, 2015 | Option Exercise | $110.33 | 516 | 56,930 | 16,129,099 | Oct 05, 2015, 07:04 PM |
| DIXON WENDY L | Director | Oct 01, 2015 | Option Exercise | $110.33 | 147 | 16,219 | 7,802 | Oct 02, 2015, 04:30 PM |
| BROOKE PAUL A | Director | Oct 01, 2015 | Option Exercise | $110.33 | 215 | 23,721 | 175,428 | Oct 02, 2015, 04:30 PM |
| BIENAIME JEAN JACQUES | Director | Oct 01, 2015 | Option Exercise | $110.33 | 131 | 14,453 | 258 | Oct 02, 2015, 04:29 PM |
| Huber Reid M | EVP, Chief Scientific Officer | Sep 21, 2015 | Option Exercise | $18.32 | 10,000 | 183,200 | 72,865 | Sep 23, 2015, 04:35 PM |
| Huber Reid M | EVP, Chief Scientific Officer | Sep 21, 2015 | Sale | $124.29 | 10,000 | 1,242,900 | 62,865 | Sep 23, 2015, 04:35 PM |
| Siegel Eric H. | EVP, General Counsel | Sep 16, 2015 | Option Exercise | $18.32 | 2,222 | 40,707 | 5,577 | Sep 18, 2015, 05:07 PM |
| Siegel Eric H. | EVP, General Counsel | Sep 16, 2015 | Sale | $130.69 | 2,222 | 290,393 | 3,355 | Sep 18, 2015, 05:07 PM |
| Levy Richard S | EVP, Chief Drug Dev Officer | Sep 11, 2015 | Sale | $130.00 | 4,301 | 559,130 | 16,926 | Sep 15, 2015, 04:31 PM |
| Levy Richard S | EVP, Chief Drug Dev Officer | Sep 08, 2015 | Option Exercise | $18.32 | 3,937 | 72,126 | 25,164 | Sep 10, 2015, 04:44 PM |
| Levy Richard S | EVP, Chief Drug Dev Officer | Sep 08, 2015 | Sale | $118.90 | 3,937 | 468,109 | 21,227 | Sep 10, 2015, 04:44 PM |
| Siegel Eric H. | EVP, General Counsel | Aug 13, 2015 | Option Exercise | $18.32 | 2,222 | 40,707 | 5,577 | Aug 17, 2015, 04:20 PM |
| Siegel Eric H. | EVP, General Counsel | Aug 13, 2015 | Sale | $107.69 | 2,222 | 239,287 | 3,355 | Aug 17, 2015, 04:20 PM |
| Levy Richard S | EVP, Chief Drug Dev Officer | Aug 06, 2015 | Option Exercise | $18.32 | 3,936 | 72,108 | 25,163 | Aug 10, 2015, 04:29 PM |
| Levy Richard S | EVP, Chief Drug Dev Officer | Aug 06, 2015 | Sale | $111.95 | 3,936 | 440,635 | 21,227 | Aug 10, 2015, 04:29 PM |
| Huber Reid M | EVP, Chief Scientific Officer | Aug 07, 2015 | Option Exercise | $17.92 | 8,397 | 150,486 | 62,857 | Aug 10, 2015, 04:29 PM |
| Wenqing Yao | EVP, Discovery Medicinal and P | Jul 15, 2015 | Option Exercise | $17.79 | 5,000 | 88,950 | 26,539 | Jul 16, 2015, 04:37 PM |
| Wenqing Yao | EVP, Discovery Medicinal and P | Jul 14, 2015 | Option Exercise | $14.72 | 7,850 | 115,552 | 29,389 | Jul 16, 2015, 04:37 PM |
| Wenqing Yao | EVP, Discovery Medicinal and P | Jul 15, 2015 | Sale | $119.75 | 5,000 | 598,750 | 21,539 | Jul 16, 2015, 04:37 PM |
| Wenqing Yao | EVP, Discovery Medicinal and P | Jul 14, 2015 | Sale | $114.75 | 7,850 | 900,788 | 21,539 | Jul 16, 2015, 04:37 PM |
| Siegel Eric H. | EVP, General Counsel | Jul 14, 2015 | Option Exercise | $18.32 | 2,222 | 40,707 | 5,577 | Jul 16, 2015, 04:37 PM |
| Siegel Eric H. | EVP, General Counsel | Jul 14, 2015 | Sale | $113.61 | 2,222 | 252,441 | 3,355 | Jul 16, 2015, 04:37 PM |
| Levy Richard S | EVP, Chief Drug Dev Officer | Jul 15, 2015 | Option Exercise | $17.79 | 70,217 | 1,249,160 | 91,444 | Jul 16, 2015, 04:36 PM |
| Levy Richard S | EVP, Chief Drug Dev Officer | Jul 15, 2015 | Sale | $120.00 | 70,217 | 8,426,040 | 21,227 | Jul 16, 2015, 04:36 PM |
| Levy Richard S | EVP, Chief Drug Dev Officer | Jul 06, 2015 | Option Exercise | $18.32 | 3,937 | 72,126 | 25,164 | Jul 08, 2015, 04:52 PM |
| Levy Richard S | EVP, Chief Drug Dev Officer | Jul 06, 2015 | Sale | $107.00 | 3,937 | 421,259 | 21,227 | Jul 08, 2015, 04:52 PM |
| BAKER JULIAN | Director | Jul 01, 2015 | Option Exercise | $104.21 | 546 | 56,899 | 12,485,965 | Jul 06, 2015, 05:40 PM |
| DIXON WENDY L | Director | Jul 01, 2015 | Option Exercise | $104.21 | 155 | 16,153 | 7,655 | Jul 06, 2015, 04:29 PM |
| BROOKE PAUL A | Director | Jul 01, 2015 | Option Exercise | $104.21 | 213 | 22,197 | 175,213 | Jul 06, 2015, 04:28 PM |
| BIENAIME JEAN JACQUES | Director | Jul 01, 2015 | Option Exercise | $104.21 | 127 | 13,235 | 127 | Jul 06, 2015, 04:28 PM |
| Daly James M | EVP, Chief Commercial Officer | Jun 23, 2015 | Option Exercise | $21.05 | 11,691 | 246,046 | 14,231 | Jun 25, 2015, 04:28 PM |
| Daly James M | EVP, Chief Commercial Officer | Jun 23, 2015 | Sale | $108.24 | 11,691 | 1,265,470 | 3,521 | Jun 25, 2015, 04:28 PM |
| Levy Richard S | EVP, Chief Drug Dev Officer | Jun 19, 2015 | Option Exercise | $17.79 | 20,000 | 355,800 | 41,227 | Jun 23, 2015, 04:28 PM |
| Levy Richard S | EVP, Chief Drug Dev Officer | Jun 19, 2015 | Sale | $108.13 | 20,000 | 2,162,600 | 21,227 | Jun 23, 2015, 04:28 PM |
| Siegel Eric H. | EVP, General Counsel | Jun 12, 2015 | Option Exercise | $18.32 | 2,223 | 40,725 | 5,578 | Jun 16, 2015, 04:02 PM |
| Siegel Eric H. | EVP, General Counsel | Jun 12, 2015 | Sale | $105.31 | 2,223 | 234,104 | 3,355 | Jun 16, 2015, 04:02 PM |
| Levy Richard S | EVP, Chief Drug Dev Officer | Jun 08, 2015 | Option Exercise | $18.32 | 3,937 | 72,126 | 25,164 | Jun 10, 2015, 04:43 PM |
| Levy Richard S | EVP, Chief Drug Dev Officer | Jun 08, 2015 | Sale | $107.58 | 3,937 | 423,542 | 21,227 | Jun 10, 2015, 04:43 PM |
| FRIEDMAN PAUL A | Director | May 26, 2015 | Option Exercise | $14.72 | 127,619 | 1,878,552 | 425,137 | May 28, 2015, 04:32 PM |
| FRIEDMAN PAUL A | Director | May 27, 2015 | Option Exercise | $14.72 | 69,132 | 1,017,623 | 366,650 | May 28, 2015, 04:32 PM |
| FRIEDMAN PAUL A | Director | May 27, 2015 | Sale | $107.55 | 69,132 | 7,435,026 | 313,954 | May 28, 2015, 04:32 PM |
| FRIEDMAN PAUL A | Director | May 26, 2015 | Sale | $107.05 | 127,619 | 13,661,652 | 422,518 | May 28, 2015, 04:32 PM |
| Daly James M | EVP, Chief Commercial Officer | May 26, 2015 | Option Exercise | $20.90 | 12,093 | 252,728 | 14,633 | May 28, 2015, 04:31 PM |
| Daly James M | EVP, Chief Commercial Officer | May 26, 2015 | Sale | $106.40 | 12,093 | 1,286,636 | 3,521 | May 28, 2015, 04:31 PM |
| FRIEDMAN PAUL A | Director | May 21, 2015 | Option Exercise | $14.72 | 22,651 | 333,423 | 320,169 | May 26, 2015, 04:57 PM |
| FRIEDMAN PAUL A | Director | May 22, 2015 | Option Exercise | $14.72 | 79,592 | 1,171,594 | 377,110 | May 26, 2015, 04:57 PM |
| FRIEDMAN PAUL A | Director | May 22, 2015 | Sale | $108.04 | 79,592 | 8,599,179 | 362,718 | May 26, 2015, 04:57 PM |
| FRIEDMAN PAUL A | Director | May 21, 2015 | Sale | $108.86 | 22,651 | 2,465,742 | 311,906 | May 26, 2015, 04:57 PM |
| BROOKE PAUL A | Director | May 18, 2015 | Option Exercise | $7.68 | 20,000 | 153,600 | 175,000 | May 20, 2015, 04:09 PM |
| Siegel Eric H. | EVP, General Counsel | May 14, 2015 | Option Exercise | $18.32 | 2,222 | 40,707 | 5,577 | May 15, 2015, 04:08 PM |
| Siegel Eric H. | EVP, General Counsel | May 14, 2015 | Sale | $104.99 | 2,222 | 233,288 | 3,355 | May 15, 2015, 04:08 PM |
| BAKER JULIAN | Director | May 11, 2015 | Option Exercise | $7.68 | 60,000 | 460,800 | 12,485,783 | May 12, 2015, 06:58 PM |
| Levy Richard S | EVP, Chief Drug Dev Officer | May 06, 2015 | Option Exercise | $18.32 | 7,412 | 135,788 | 28,639 | May 08, 2015, 04:02 PM |
| Levy Richard S | EVP, Chief Drug Dev Officer | May 06, 2015 | Sale | $99.43 | 7,412 | 736,975 | 21,227 | May 08, 2015, 04:02 PM |
| Daly James M | EVP, Chief Commercial Officer | Apr 23, 2015 | Option Exercise | $35.97 | 36,941 | 1,328,838 | 25,744 | Apr 24, 2015, 04:20 PM |
| Daly James M | EVP, Chief Commercial Officer | Apr 23, 2015 | Sale | $107.67 | 36,941 | 3,977,437 | 3,521 | Apr 24, 2015, 04:20 PM |
| Wenqing Yao | EVP, Discovery Medicinal and P | Apr 17, 2015 | Sale | $102.04 | 7,150 | 729,586 | 21,539 | Apr 21, 2015, 04:58 PM |
| Huber Reid M | EVP, Chief Scientific Officer | Apr 16, 2015 | Option Exercise | $14.74 | 10,060 | 148,286 | 54,460 | Apr 17, 2015, 05:10 PM |
| Siegel Eric H. | EVP, General Counsel | Apr 14, 2015 | Option Exercise | $18.32 | 2,222 | 40,707 | 4,466 | Apr 16, 2015, 04:29 PM |
| Siegel Eric H. | EVP, General Counsel | Apr 14, 2015 | Sale | $98.72 | 2,222 | 219,356 | 3,355 | Apr 16, 2015, 04:29 PM |
| SWAIN PAULA J | EVP, Human Resources | Apr 13, 2015 | Option Exercise | $3.11 | 16,469 | 51,219 | 37,552 | Apr 14, 2015, 04:15 PM |
| SWAIN PAULA J | EVP, Human Resources | Apr 13, 2015 | Sale | $96.29 | 16,469 | 1,585,800 | 21,083 | Apr 14, 2015, 04:15 PM |
| Wenqing Yao | EVP, Discovery Medicinal and P | Apr 13, 2015 | Option Exercise | $17.79 | 14,000 | 249,060 | 42,689 | Apr 14, 2015, 04:14 PM |
| Wenqing Yao | EVP, Discovery Medicinal and P | Apr 10, 2015 | Option Exercise | $17.79 | 9,000 | 160,110 | 37,689 | Apr 14, 2015, 04:14 PM |
| Wenqing Yao | EVP, Discovery Medicinal and P | Apr 13, 2015 | Sale | $96.75 | 14,000 | 1,354,500 | 28,689 | Apr 14, 2015, 04:14 PM |
| Wenqing Yao | EVP, Discovery Medicinal and P | Apr 10, 2015 | Sale | $92.75 | 9,000 | 834,750 | 28,689 | Apr 14, 2015, 04:14 PM |
| Wenqing Yao | EVP, Discovery Medicinal and P | Apr 07, 2015 | Option Exercise | $17.79 | 5,000 | 88,950 | 48,720 | Apr 08, 2015, 04:18 PM |
| Wenqing Yao | EVP, Discovery Medicinal and P | Apr 07, 2015 | Sale | $90.13 | 20,031 | 1,805,439 | 43,720 | Apr 08, 2015, 04:18 PM |
| Levy Richard S | EVP, Chief Drug Dev Officer | Apr 06, 2015 | Option Exercise | $18.32 | 25,000 | 458,000 | 46,227 | Apr 08, 2015, 04:17 PM |
| Levy Richard S | EVP, Chief Drug Dev Officer | Apr 06, 2015 | Sale | $88.77 | 25,000 | 2,219,250 | 21,227 | Apr 08, 2015, 04:17 PM |
| Chardonnet Laurent | Vice President and Treasurer | Mar 30, 2015 | Option Exercise | $16.61 | 113,776 | 1,889,296 | 116,681 | Apr 01, 2015, 04:27 PM |
| Chardonnet Laurent | Vice President and Treasurer | Mar 30, 2015 | Sale | $93.64 | 113,776 | 10,653,985 | 70,681 | Apr 01, 2015, 04:27 PM |
| Huber Reid M | EVP, Chief Scientific Officer | Mar 30, 2015 | Option Exercise | $18.06 | 34,263 | 618,813 | 78,671 | Apr 01, 2015, 04:26 PM |
| Huber Reid M | EVP, Chief Scientific Officer | Mar 30, 2015 | Sale | $93.66 | 34,263 | 3,209,206 | 68,671 | Apr 01, 2015, 04:26 PM |
| SWAIN PAULA J | EVP, Human Resources | Mar 16, 2015 | Option Exercise | $3.11 | 17,500 | 54,425 | 38,583 | Mar 18, 2015, 04:33 PM |
| SWAIN PAULA J | EVP, Human Resources | Mar 16, 2015 | Sale | $89.97 | 17,500 | 1,574,475 | 21,083 | Mar 18, 2015, 04:33 PM |
| ARIKO BARRY A | Director | Mar 12, 2015 | Option Exercise | $5.96 | 80,000 | 476,800 | 125,834 | Mar 13, 2015, 04:28 PM |
| ARIKO BARRY A | Director | Mar 12, 2015 | Sale | $89.27 | 80,000 | 7,141,600 | 45,834 | Mar 13, 2015, 04:28 PM |
| Siegel Eric H. | EVP, General Counsel | Mar 12, 2015 | Option Exercise | $18.32 | 2,222 | 40,707 | 4,466 | Mar 13, 2015, 04:27 PM |
| Siegel Eric H. | EVP, General Counsel | Mar 12, 2015 | Sale | $89.72 | 2,222 | 199,347 | 3,355 | Mar 13, 2015, 04:27 PM |
| Wenqing Yao | EVP, Discovery Medicinal and P | Mar 10, 2015 | Option Exercise | $17.90 | 4,404 | 78,820 | 43,720 | Mar 10, 2015, 05:36 PM |
| Levy Richard S | EVP, Chief Drug Dev Officer | Mar 06, 2015 | Option Exercise | $18.32 | 25,000 | 458,000 | 46,227 | Mar 10, 2015, 05:13 PM |
| Levy Richard S | EVP, Chief Drug Dev Officer | Mar 06, 2015 | Sale | $89.91 | 25,000 | 2,247,750 | 21,227 | Mar 10, 2015, 05:13 PM |
| Siegel Eric H. | EVP, General Counsel | Mar 05, 2015 | Option Exercise | $18.32 | 13,333 | 244,261 | 16,688 | Mar 09, 2015, 04:37 PM |
| Siegel Eric H. | EVP, General Counsel | Mar 05, 2015 | Sale | $90.00 | 13,333 | 1,199,970 | 3,355 | Mar 09, 2015, 04:37 PM |
| DE SCHUTTER RICHARD U | Director | Mar 05, 2015 | Option Exercise | $16.15 | 40,000 | 646,200 | 124,759 | Mar 09, 2015, 04:35 PM |
| DE SCHUTTER RICHARD U | Director | Mar 05, 2015 | Sale | $92.09 | 40,000 | 3,683,759 | 92,290 | Mar 09, 2015, 04:35 PM |
| Siegel Eric H. | EVP, General Counsel | Feb 25, 2015 | Option Exercise | $18.32 | 13,333 | 244,261 | 16,688 | Feb 25, 2015, 05:29 PM |
| Siegel Eric H. | EVP, General Counsel | Feb 25, 2015 | Sale | $85.00 | 13,333 | 1,133,305 | 3,355 | Feb 25, 2015, 05:29 PM |
| Daly James M | EVP, Chief Commercial Officer | Feb 24, 2015 | Option Exercise | $16.62 | 8,334 | 138,511 | 11,855 | Feb 25, 2015, 05:29 PM |
| Daly James M | EVP, Chief Commercial Officer | Feb 23, 2015 | Option Exercise | $18.32 | 2,778 | 50,893 | 6,299 | Feb 25, 2015, 05:29 PM |
| Daly James M | EVP, Chief Commercial Officer | Feb 24, 2015 | Sale | $81.77 | 8,334 | 681,471 | 3,521 | Feb 25, 2015, 05:29 PM |
| Daly James M | EVP, Chief Commercial Officer | Feb 23, 2015 | Sale | $83.44 | 2,778 | 231,796 | 3,521 | Feb 25, 2015, 05:29 PM |
| ARIKO BARRY A | Director | Feb 18, 2015 | Option Exercise | $7.68 | 20,000 | 153,600 | 65,834 | Feb 20, 2015, 04:43 PM |
| ARIKO BARRY A | Director | Feb 18, 2015 | Sale | $78.43 | 20,000 | 1,568,600 | 45,834 | Feb 20, 2015, 04:43 PM |
| Hoppenot Herve | Chief Executive Officer | Feb 13, 2015 | Option Exercise | $75.94 | 30,534 | 2,318,752 | 382,058 | Feb 18, 2015, 05:50 PM |
| FRIEDMAN PAUL A | Director | Feb 13, 2015 | Sale | $74.32 | 120,000 | 8,918,400 | 357,518 | Feb 18, 2015, 05:49 PM |
| Levy Richard S | EVP, Chief Drug Dev&Medical Of | Feb 17, 2015 | Option Exercise | $15.66 | 12,000 | 187,947 | 30,205 | Feb 18, 2015, 05:49 PM |
| Levy Richard S | EVP, Chief Drug Dev&Medical Of | Feb 17, 2015 | Sale | $76.90 | 12,000 | 922,800 | 18,205 | Feb 18, 2015, 05:49 PM |
| SWAIN PAULA J | EVP, Human Resources | Feb 17, 2015 | Option Exercise | $3.11 | 17,500 | 54,425 | 38,583 | Feb 18, 2015, 05:47 PM |
| SWAIN PAULA J | EVP, Human Resources | Feb 17, 2015 | Sale | $76.90 | 17,500 | 1,345,750 | 21,083 | Feb 18, 2015, 05:47 PM |
| Levy Richard S | EVP, Chief Drug Dev&Medical Of | Feb 06, 2015 | Option Exercise | $18.32 | 25,000 | 458,000 | 43,205 | Feb 10, 2015, 04:33 PM |
| Levy Richard S | EVP, Chief Drug Dev&Medical Of | Feb 06, 2015 | Sale | $75.11 | 25,000 | 1,877,750 | 18,205 | Feb 10, 2015, 04:33 PM |
| Daly James M | EVP, Chief Commercial Officer | Jan 23, 2015 | Option Exercise | $17.04 | 11,109 | 189,352 | 14,630 | Jan 26, 2015, 04:57 PM |
| Daly James M | EVP, Chief Commercial Officer | Jan 23, 2015 | Sale | $77.68 | 11,109 | 862,947 | 3,521 | Jan 26, 2015, 04:57 PM |
| Siegel Eric H. | EVP, General Counsel | Jan 23, 2015 | Option Exercise | $17.79 | 11,458 | 203,838 | 14,813 | Jan 26, 2015, 04:57 PM |
| Siegel Eric H. | EVP, General Counsel | Jan 22, 2015 | Option Exercise | $17.79 | 1,042 | 18,537 | 4,397 | Jan 26, 2015, 04:57 PM |
| Siegel Eric H. | EVP, General Counsel | Jan 26, 2015 | Option Exercise | $17.79 | 1,042 | 18,537 | 4,397 | Jan 26, 2015, 04:57 PM |
| Siegel Eric H. | EVP, General Counsel | Jan 22, 2015 | Sale | $77.99 | 1,042 | 81,266 | 3,355 | Jan 26, 2015, 04:57 PM |
| Siegel Eric H. | EVP, General Counsel | Jan 26, 2015 | Sale | $80.00 | 1,042 | 83,360 | 3,355 | Jan 26, 2015, 04:57 PM |
| Siegel Eric H. | EVP, General Counsel | Jan 23, 2015 | Sale | $80.00 | 11,458 | 916,640 | 3,355 | Jan 26, 2015, 04:57 PM |
| SWAIN PAULA J | EVP, Human Resources | Jan 20, 2015 | Option Exercise | $3.11 | 17,500 | 54,425 | 38,583 | Jan 20, 2015, 05:28 PM |
| SWAIN PAULA J | EVP, Human Resources | Jan 20, 2015 | Sale | $74.17 | 17,500 | 1,297,975 | 21,083 | Jan 20, 2015, 05:28 PM |
| Levy Richard S | EVP, Chief Drug Dev&Medical Of | Jan 16, 2015 | Option Exercise | $14.72 | 12,000 | 176,640 | 30,205 | Jan 20, 2015, 05:27 PM |
| Levy Richard S | EVP, Chief Drug Dev&Medical Of | Jan 16, 2015 | Sale | $73.07 | 12,000 | 876,840 | 18,205 | Jan 20, 2015, 05:27 PM |
| Siegel Eric H. | EVP, General Counsel | Jan 08, 2015 | Option Exercise | $16.78 | 15,626 | 262,194 | 18,981 | Jan 12, 2015, 05:06 PM |
| Siegel Eric H. | EVP, General Counsel | Jan 08, 2015 | Sale | $75.00 | 15,626 | 1,171,950 | 3,355 | Jan 12, 2015, 05:06 PM |
| Levy Richard S | EVP, Chief Drug Dev&Medical Of | Jan 06, 2015 | Option Exercise | $18.32 | 25,000 | 458,000 | 43,205 | Jan 08, 2015, 05:34 PM |
| Levy Richard S | EVP, Chief Drug Dev&Medical Of | Jan 06, 2015 | Sale | $71.84 | 25,000 | 1,796,000 | 18,205 | Jan 08, 2015, 05:34 PM |
| SWAIN PAULA J | EVP, Human Resources | Jan 05, 2015 | Option Exercise | $3.11 | 17,500 | 54,425 | 35,561 | Jan 07, 2015, 04:29 PM |
| SWAIN PAULA J | EVP, Human Resources | Jan 05, 2015 | Sale | $73.90 | 17,500 | 1,293,250 | 18,061 | Jan 07, 2015, 04:29 PM |
| Daly James M | EVP, Chief Commercial Officer | Dec 23, 2014 | Option Exercise | $17.04 | 11,113 | 189,421 | 11,113 | Dec 29, 2014, 04:05 PM |
| Daly James M | EVP, Chief Commercial Officer | Dec 23, 2014 | Sale | $74.43 | 11,113 | 827,141 | 0 | Dec 29, 2014, 04:05 PM |
| Levy Richard S | EVP, Chief Drug Dev&Medical Of | Dec 16, 2014 | Option Exercise | $14.72 | 12,000 | 176,640 | 30,205 | Dec 18, 2014, 04:17 PM |
| Levy Richard S | EVP, Chief Drug Dev&Medical Of | Dec 16, 2014 | Sale | $72.36 | 12,000 | 868,320 | 18,205 | Dec 18, 2014, 04:17 PM |
| DE SCHUTTER RICHARD U | Director | Dec 02, 2014 | Sale | $74.87 | 47,800 | 3,578,786 | 105,000 | Dec 03, 2014, 04:33 PM |
| DE SCHUTTER RICHARD U | Director | Dec 01, 2014 | Sale | $75.26 | 2,200 | 165,572 | 152,800 | Dec 03, 2014, 04:33 PM |
| Huber Reid M | EVP, Chief Scientific Officer | Dec 02, 2014 | Option Exercise | $9.41 | 6,494 | 61,109 | 41,386 | Dec 03, 2014, 04:33 PM |
| Daly James M | EVP, Chief Commercial Officer | Nov 24, 2014 | Option Exercise | $17.05 | 11,111 | 189,387 | 11,111 | Nov 26, 2014, 04:13 PM |
| Daly James M | EVP, Chief Commercial Officer | Nov 24, 2014 | Sale | $74.08 | 11,111 | 823,103 | 0 | Nov 26, 2014, 04:13 PM |
| Levy Richard S | EVP, Chief Drug Dev&Medical Of | Nov 17, 2014 | Option Exercise | $14.72 | 12,000 | 176,640 | 30,205 | Nov 19, 2014, 04:49 PM |
| Levy Richard S | EVP, Chief Drug Dev&Medical Of | Nov 17, 2014 | Sale | $69.97 | 12,000 | 839,640 | 18,205 | Nov 19, 2014, 04:49 PM |
| Huber Reid M | EVP, Chief Scientific Officer | Nov 12, 2014 | Option Exercise | $6.24 | 17,960 | 112,031 | 34,892 | Nov 14, 2014, 04:06 PM |
| FRIEDMAN PAUL A | Director | Nov 06, 2014 | Option Exercise | $10.03 | 185,653 | 1,861,617 | 603,171 | Nov 07, 2014, 05:08 PM |
| FRIEDMAN PAUL A | Director | Nov 06, 2014 | Sale | $67.87 | 185,653 | 12,600,270 | 417,518 | Nov 07, 2014, 05:08 PM |
| Daly James M | EVP, Chief Commercial Officer | Oct 23, 2014 | Option Exercise | $17.05 | 11,111 | 189,387 | 11,111 | Oct 24, 2014, 04:14 PM |
| Daly James M | EVP, Chief Commercial Officer | Oct 23, 2014 | Sale | $53.49 | 11,111 | 594,327 | 0 | Oct 24, 2014, 04:14 PM |
| Levy Richard S | EVP, Chief Drug Dev&Medical Of | Oct 23, 2014 | Option Exercise | $3.11 | 13,904 | 43,241 | 18,205 | Oct 24, 2014, 04:13 PM |
| Levy Richard S | EVP, Chief Drug Dev&Medical Of | Oct 16, 2014 | Option Exercise | $14.72 | 8,000 | 117,760 | 12,301 | Oct 20, 2014, 04:10 PM |
| Levy Richard S | EVP, Chief Drug Dev&Medical Of | Oct 16, 2014 | Sale | $49.03 | 8,000 | 392,240 | 4,301 | Oct 20, 2014, 04:10 PM |
| Daly James M | EVP, Chief Commercial Officer | Sep 23, 2014 | Option Exercise | $17.04 | 11,111 | 189,386 | 11,111 | Sep 25, 2014, 04:14 PM |
| Daly James M | EVP, Chief Commercial Officer | Sep 23, 2014 | Sale | $47.65 | 11,111 | 529,439 | 0 | Sep 25, 2014, 04:14 PM |
| Levy Richard S | EVP, Chief Drug Dev&Medical Of | Sep 16, 2014 | Option Exercise | $14.72 | 8,000 | 117,760 | 12,301 | Sep 18, 2014, 04:11 PM |
| Levy Richard S | EVP, Chief Drug Dev&Medical Of | Sep 16, 2014 | Sale | $47.58 | 8,000 | 380,640 | 4,301 | Sep 18, 2014, 04:11 PM |
| Daly James M | EVP, Chief Commercial Officer | Aug 25, 2014 | Option Exercise | $17.05 | 11,111 | 189,387 | 11,111 | Aug 27, 2014, 04:25 PM |
| Daly James M | EVP, Chief Commercial Officer | Aug 25, 2014 | Sale | $51.96 | 11,111 | 577,328 | 0 | Aug 27, 2014, 04:25 PM |
| Levy Richard S | EVP, Chief Drug Dev&Medical Of | Aug 18, 2014 | Option Exercise | $14.72 | 8,000 | 117,760 | 12,301 | Aug 19, 2014, 05:43 PM |
| Levy Richard S | EVP, Chief Drug Dev&Medical Of | Aug 18, 2014 | Sale | $51.97 | 8,000 | 415,760 | 4,301 | Aug 19, 2014, 05:43 PM |
| Daly James M | EVP, Chief Commercial Officer | Jul 23, 2014 | Option Exercise | $17.05 | 11,111 | 189,387 | 11,111 | Jul 25, 2014, 05:51 PM |
| Daly James M | EVP, Chief Commercial Officer | Jul 23, 2014 | Sale | $48.54 | 11,111 | 539,328 | 0 | Jul 25, 2014, 05:51 PM |
| Levy Richard S | EVP, Chief Drug Dev&Medical Of | Jul 16, 2014 | Option Exercise | $14.72 | 8,000 | 117,760 | 12,301 | Jul 18, 2014, 05:11 PM |
| Levy Richard S | EVP, Chief Drug Dev&Medical Of | Jul 16, 2014 | Sale | $48.15 | 8,000 | 385,200 | 4,301 | Jul 18, 2014, 05:11 PM |
| Daly James M | EVP, Chief Commercial Officer | Jun 23, 2014 | Option Exercise | $17.04 | 11,111 | 189,386 | 8,334 | Jun 25, 2014, 04:03 PM |
| Daly James M | EVP, Chief Commercial Officer | Jun 23, 2014 | Sale | $56.03 | 11,111 | 622,605 | 0 | Jun 25, 2014, 04:03 PM |
| Levy Richard S | EVP, Chief Drug Dev&Medical Of | Jun 16, 2014 | Option Exercise | $14.72 | 8,000 | 117,760 | 12,301 | Jun 18, 2014, 04:02 PM |
| Levy Richard S | EVP, Chief Drug Dev&Medical Of | Jun 16, 2014 | Sale | $53.88 | 8,000 | 431,040 | 4,301 | Jun 18, 2014, 04:02 PM |
| HASTINGS DAVID C | Chief Financial Officer | Jun 05, 2014 | Option Exercise | $5.28 | 123,966 | 654,020 | 132,466 | Jun 06, 2014, 06:47 PM |
| HASTINGS DAVID C | Chief Financial Officer | Jun 04, 2014 | Option Exercise | $13.55 | 76,034 | 1,030,410 | 84,534 | Jun 06, 2014, 06:47 PM |
| HASTINGS DAVID C | Chief Financial Officer | Jun 05, 2014 | Sale | $52.81 | 123,966 | 6,546,645 | 8,500 | Jun 06, 2014, 06:47 PM |
| HASTINGS DAVID C | Chief Financial Officer | Jun 04, 2014 | Sale | $52.61 | 76,034 | 4,000,149 | 8,500 | Jun 06, 2014, 06:47 PM |
| Daly James M | EVP, Chief Commercial Officer | May 23, 2014 | Option Exercise | $17.05 | 11,111 | 189,387 | 11,111 | May 28, 2014, 04:25 PM |
| Daly James M | EVP, Chief Commercial Officer | May 23, 2014 | Sale | $48.48 | 11,111 | 538,661 | 0 | May 28, 2014, 04:25 PM |
| BAKER JULIAN | Director | May 21, 2014 | Option Exercise | $7.02 | 30,000 | 210,600 | 12,465,783 | May 23, 2014, 05:07 PM |
| Levy Richard S | EVP, Chief Drug Dev&Medical Of | May 16, 2014 | Option Exercise | $14.72 | 8,000 | 117,760 | 12,301 | May 20, 2014, 04:09 PM |
| Levy Richard S | EVP, Chief Drug Dev&Medical Of | May 16, 2014 | Sale | $50.68 | 8,000 | 405,440 | 4,301 | May 20, 2014, 04:09 PM |
| Chardonnet Laurent | Vice President and Treasurer | May 12, 2014 | Sale | $54.00 | 2,058 | 111,132 | 1,753 | May 14, 2014, 04:35 PM |
| Chardonnet Laurent | Vice President and Treasurer | May 02, 2014 | Option Exercise | $9.41 | 34,000 | 319,940 | 37,811 | May 06, 2014, 04:11 PM |
| Chardonnet Laurent | Vice President and Treasurer | May 02, 2014 | Sale | $51.55 | 34,000 | 1,752,700 | 3,811 | May 06, 2014, 04:11 PM |
| BROOKE PAUL A | Director | Apr 28, 2014 | Option Exercise | $7.02 | 25,000 | 175,500 | 135,000 | Apr 30, 2014, 04:17 PM |
| Daly James M | EVP, Chief Commercial Officer | Apr 23, 2014 | Option Exercise | $16.93 | 30,555 | 517,268 | 30,555 | Apr 25, 2014, 04:07 PM |
| Daly James M | EVP, Chief Commercial Officer | Apr 23, 2014 | Sale | $47.71 | 30,555 | 1,457,779 | 0 | Apr 25, 2014, 04:07 PM |
| FRIEDMAN PAUL A | Director | Feb 20, 2014 | Option Exercise | $3.11 | 33,354 | 103,731 | 450,872 | Feb 21, 2014, 05:09 PM |
| FRIEDMAN PAUL A | Director | Feb 20, 2014 | Sale | $63.51 | 33,354 | 2,118,312 | 417,518 | Feb 21, 2014, 05:09 PM |
| DE SCHUTTER RICHARD U | Director | Feb 18, 2014 | Option Exercise | $8.88 | 42,545 | 377,800 | 197,545 | Feb 19, 2014, 05:39 PM |
| DE SCHUTTER RICHARD U | Director | Feb 19, 2014 | Option Exercise | $8.88 | 7,455 | 66,200 | 162,455 | Feb 19, 2014, 05:39 PM |
| DE SCHUTTER RICHARD U | Director | Feb 18, 2014 | Sale | $65.54 | 42,545 | 2,788,399 | 155,000 | Feb 19, 2014, 05:39 PM |
| DE SCHUTTER RICHARD U | Director | Feb 19, 2014 | Sale | $65.50 | 7,455 | 488,303 | 155,000 | Feb 19, 2014, 05:39 PM |
| FRIEDMAN PAUL A | Director | Feb 14, 2014 | Option Exercise | $11.98 | 10,227 | 122,519 | 427,745 | Feb 19, 2014, 05:39 PM |
| FRIEDMAN PAUL A | Director | Feb 19, 2014 | Option Exercise | $3.11 | 40,919 | 127,258 | 458,437 | Feb 19, 2014, 05:39 PM |
| FRIEDMAN PAUL A | Director | Feb 18, 2014 | Option Exercise | $7.85 | 720,036 | 5,653,274 | 1,137,554 | Feb 19, 2014, 05:39 PM |
| FRIEDMAN PAUL A | Director | Feb 19, 2014 | Sale | $62.66 | 40,919 | 2,563,985 | 417,518 | Feb 19, 2014, 05:39 PM |
| FRIEDMAN PAUL A | Director | Feb 18, 2014 | Sale | $65.82 | 720,036 | 47,392,769 | 417,518 | Feb 19, 2014, 05:39 PM |
| FRIEDMAN PAUL A | Director | Feb 14, 2014 | Sale | $65.52 | 10,227 | 670,073 | 417,518 | Feb 19, 2014, 05:39 PM |
| ARIKO BARRY A | Director | Feb 13, 2014 | Option Exercise | $7.02 | 10,000 | 70,200 | 55,834 | Feb 18, 2014, 06:05 PM |
| ARIKO BARRY A | Director | Feb 13, 2014 | Sale | $66.49 | 10,000 | 664,900 | 45,834 | Feb 18, 2014, 06:05 PM |
| SWAIN PAULA J | EVP, Human Resources | Feb 13, 2014 | Option Exercise | $10.56 | 216,967 | 2,290,590 | 235,028 | Feb 18, 2014, 06:04 PM |
| SWAIN PAULA J | EVP, Human Resources | Feb 13, 2014 | Sale | $66.73 | 216,967 | 14,478,209 | 18,061 | Feb 18, 2014, 06:04 PM |
| Siegel Eric H. | EVP, General Counsel | Feb 13, 2014 | Option Exercise | $17.28 | 54,855 | 948,058 | 56,042 | Feb 18, 2014, 06:04 PM |
| Siegel Eric H. | EVP, General Counsel | Feb 13, 2014 | Sale | $66.67 | 56,042 | 3,736,118 | 1,187 | Feb 18, 2014, 06:04 PM |
| Chardonnet Laurent | Vice President and Treasurer | Feb 13, 2014 | Option Exercise | $9.24 | 98,334 | 908,621 | 101,527 | Feb 18, 2014, 06:03 PM |
| Chardonnet Laurent | Vice President and Treasurer | Feb 13, 2014 | Sale | $66.28 | 98,334 | 6,517,577 | 3,193 | Feb 18, 2014, 06:03 PM |
| HASTINGS DAVID C | Chief Financial Officer | Feb 18, 2014 | Option Exercise | $8.99 | 32,001 | 287,689 | 40,501 | Feb 18, 2014, 06:03 PM |
| HASTINGS DAVID C | Chief Financial Officer | Feb 14, 2014 | Option Exercise | $8.99 | 40,000 | 359,600 | 48,500 | Feb 18, 2014, 06:03 PM |
| HASTINGS DAVID C | Chief Financial Officer | Feb 13, 2014 | Option Exercise | $14.43 | 202,999 | 2,928,531 | 211,499 | Feb 18, 2014, 06:03 PM |
| HASTINGS DAVID C | Chief Financial Officer | Feb 18, 2014 | Sale | $65.64 | 32,001 | 2,100,546 | 8,500 | Feb 18, 2014, 06:03 PM |
| HASTINGS DAVID C | Chief Financial Officer | Feb 14, 2014 | Sale | $64.74 | 40,000 | 2,589,600 | 8,500 | Feb 18, 2014, 06:03 PM |
| HASTINGS DAVID C | Chief Financial Officer | Feb 13, 2014 | Sale | $66.12 | 202,999 | 13,422,294 | 8,500 | Feb 18, 2014, 06:03 PM |
| Levy Richard S | EVP, Chief Drug Dev&Medical Of | Feb 14, 2014 | Option Exercise | $10.89 | 39,787 | 433,346 | 44,088 | Feb 18, 2014, 06:02 PM |
| Levy Richard S | EVP, Chief Drug Dev&Medical Of | Feb 13, 2014 | Option Exercise | $8.34 | 191,309 | 1,595,213 | 195,610 | Feb 18, 2014, 06:02 PM |
| Levy Richard S | EVP, Chief Drug Dev&Medical Of | Feb 14, 2014 | Sale | $66.13 | 39,787 | 2,631,114 | 4,301 | Feb 18, 2014, 06:02 PM |
| Levy Richard S | EVP, Chief Drug Dev&Medical Of | Feb 13, 2014 | Sale | $66.38 | 191,309 | 12,699,091 | 4,301 | Feb 18, 2014, 06:02 PM |
| Daly James M | EVP, Chief Commercial Officer | Feb 13, 2014 | Option Exercise | $16.98 | 158,331 | 2,688,127 | 158,331 | Feb 18, 2014, 06:02 PM |
| Daly James M | EVP, Chief Commercial Officer | Feb 13, 2014 | Sale | $66.49 | 158,331 | 10,527,428 | 0 | Feb 18, 2014, 06:02 PM |
| FRIEDMAN PAUL A | Chief Executive Officer | Dec 20, 2013 | Option Exercise | $50.11 | 24,350 | 1,220,179 | 417,518 | Dec 20, 2013, 04:15 PM |
| WHITFIELD ROY A | Director | Dec 17, 2013 | Option Exercise | $7.35 | 45,000 | 330,600 | 666,082 | Dec 19, 2013, 04:07 PM |
| WHITFIELD ROY A | Director | Nov 18, 2013 | Sale | $47.37 | 50,000 | 2,368,500 | 621,082 | Nov 20, 2013, 04:28 PM |
| FRIEDMAN PAUL A | Chief Executive Officer | Sep 10, 2013 | Option Exercise | $7.86 | 376,789 | 2,962,344 | 768,657 | Sep 12, 2013, 04:29 PM |
| FRIEDMAN PAUL A | Chief Executive Officer | Sep 10, 2013 | Sale | $37.32 | 376,789 | 14,061,765 | 391,868 | Sep 12, 2013, 04:29 PM |
| Chardonnet Laurent | Vice President and Treasurer | Sep 05, 2013 | Option Exercise | $8.56 | 41,800 | 357,862 | 46,857 | Sep 09, 2013, 04:14 PM |
| Chardonnet Laurent | Vice President and Treasurer | Sep 09, 2013 | Sale | $37.90 | 36,067 | 1,366,939 | 2,023 | Sep 09, 2013, 04:14 PM |
| Chardonnet Laurent | Vice President and Treasurer | Sep 05, 2013 | Sale | $34.90 | 8,767 | 305,968 | 38,090 | Sep 09, 2013, 04:14 PM |
| SWAIN PAULA J | EVP, Human Resources | Sep 05, 2013 | Option Exercise | $7.09 | 94,444 | 669,608 | 112,505 | Sep 09, 2013, 04:13 PM |
| SWAIN PAULA J | EVP, Human Resources | Sep 05, 2013 | Sale | $35.06 | 94,444 | 3,311,207 | 18,061 | Sep 09, 2013, 04:13 PM |
| HASTINGS DAVID C | Chief Financial Officer | Sep 06, 2013 | Option Exercise | $7.09 | 100,000 | 709,000 | 108,500 | Sep 09, 2013, 04:13 PM |
| HASTINGS DAVID C | Chief Financial Officer | Sep 06, 2013 | Sale | $35.16 | 100,000 | 3,516,000 | 8,500 | Sep 09, 2013, 04:13 PM |
| Siegel Eric H. | EVP, General Counsel | Sep 06, 2013 | Option Exercise | $16.95 | 55,978 | 948,594 | 56,877 | Sep 09, 2013, 04:13 PM |
| Siegel Eric H. | EVP, General Counsel | Sep 06, 2013 | Sale | $35.17 | 55,978 | 1,968,746 | 899 | Sep 09, 2013, 04:13 PM |
| Levy Richard S | EVP, Chief Drug Dev&Medical Of | Sep 06, 2013 | Option Exercise | $11.98 | 25,000 | 299,500 | 25,000 | Sep 09, 2013, 04:13 PM |
| Levy Richard S | EVP, Chief Drug Dev&Medical Of | Sep 06, 2013 | Sale | $35.28 | 25,000 | 882,000 | 0 | Sep 09, 2013, 04:13 PM |
| WHITFIELD ROY A | Director | Aug 19, 2013 | Sale | $26.70 | 50,000 | 1,335,000 | 671,082 | Aug 20, 2013, 05:53 PM |
| BAKER JULIAN | Director | Jun 11, 2013 | Option Exercise | $4.44 | 30,000 | 133,200 | 12,455,783 | Jun 13, 2013, 06:49 PM |
| WHITFIELD ROY A | Director | May 17, 2013 | Sale | $23.08 | 40,000 | 923,200 | 721,082 | May 21, 2013, 04:33 PM |
| Levy Richard S | EVP, Chief Drug Dev&Medical Of | May 13, 2013 | Option Exercise | $7.09 | 60,000 | 425,400 | 60,000 | May 15, 2013, 04:17 PM |
| Levy Richard S | EVP, Chief Drug Dev&Medical Of | May 13, 2013 | Sale | $22.30 | 55,699 | 1,242,088 | 4,301 | May 15, 2013, 04:17 PM |
| FRIEDMAN PAUL A | Chief Executive Officer | May 06, 2013 | Option Exercise | $10.68 | 23,700 | 253,088 | 391,868 | May 07, 2013, 04:40 PM |
| ARIKO BARRY A | Director | Apr 05, 2013 | Option Exercise | $4.44 | 10,000 | 44,400 | 45,834 | Apr 08, 2013, 04:04 PM |
| WHITFIELD ROY A | Director | Mar 14, 2013 | Sale | $25.08 | 10,000 | 250,800 | 761,082 | Mar 18, 2013, 04:33 PM |
| WHITFIELD ROY A | Director | Mar 01, 2013 | Sale | $22.56 | 10,000 | 225,600 | 771,082 | Mar 05, 2013, 04:13 PM |
| Siegel Eric H. | EVP, General Counsel | Feb 28, 2013 | Option Exercise | $15.66 | 50,000 | 782,910 | 50,280 | Mar 01, 2013, 04:20 PM |
| Siegel Eric H. | EVP, General Counsel | Feb 28, 2013 | Sale | $22.16 | 50,000 | 1,108,000 | 280 | Mar 01, 2013, 04:20 PM |
| BROOKE PAUL A | Director | Feb 27, 2013 | Option Exercise | $4.44 | 10,000 | 44,400 | 110,000 | Feb 28, 2013, 04:09 PM |
| SWAIN PAULA J | EVP, Human Resources | Feb 20, 2013 | Option Exercise | $6.00 | 103,283 | 619,208 | 121,344 | Feb 22, 2013, 04:06 PM |
| SWAIN PAULA J | EVP, Human Resources | Feb 20, 2013 | Sale | $21.53 | 103,283 | 2,223,683 | 18,061 | Feb 22, 2013, 04:06 PM |
| Levy Richard S | EVP, Chief Drug Dev&Medical Of | Feb 15, 2013 | Option Exercise | $6.84 | 98,440 | 673,176 | 98,440 | Feb 20, 2013, 04:33 PM |
| Levy Richard S | EVP, Chief Drug Dev&Medical Of | Feb 15, 2013 | Sale | $22.48 | 98,440 | 2,212,931 | 0 | Feb 20, 2013, 04:33 PM |
| HASTINGS DAVID C | Chief Financial Officer | Feb 15, 2013 | Option Exercise | $6.59 | 100,000 | 658,800 | 108,500 | Feb 20, 2013, 04:33 PM |
| HASTINGS DAVID C | Chief Financial Officer | Feb 15, 2013 | Sale | $22.52 | 100,000 | 2,252,000 | 8,500 | Feb 20, 2013, 04:33 PM |
| WHITFIELD ROY A | Director | Feb 19, 2013 | Sale | $21.82 | 30,000 | 654,600 | 781,082 | Feb 20, 2013, 04:33 PM |
| FRIEDMAN PAUL A | Chief Executive Officer | Dec 20, 2012 | Option Exercise | $16.15 | 16,725 | 270,109 | 318,168 | Dec 20, 2012, 05:31 PM |
| DE SCHUTTER RICHARD U | Director | Dec 17, 2012 | Buy | $16.11 | 45,000 | 724,950 | 197,710 | Dec 19, 2012, 05:05 PM |
| DE SCHUTTER RICHARD U | Director | Dec 17, 2012 | Sale | $16.03 | 50,000 | 801,500 | 152,710 | Dec 19, 2012, 05:05 PM |
| BAKER JULIAN | Director | Aug 01, 2012 | Option Exercise | $5.67 | 10,000 | 56,700 | 66,340 | Aug 03, 2012, 05:35 PM |
| ARIKO BARRY A | Director | Jul 12, 2012 | Option Exercise | $5.67 | 10,000 | 56,700 | 35,834 | Jul 13, 2012, 04:14 PM |
| FRIEDMAN PAUL A | Chief Executive Officer | Jul 10, 2012 | Option Exercise | $7.52 | 25,186 | 189,442 | 334,893 | Jul 12, 2012, 04:32 PM |
| Chardonnet Laurent | Vice President and Treasurer | Jul 05, 2012 | Option Exercise | $7.09 | 35,700 | 253,113 | 38,734 | Jul 06, 2012, 04:08 PM |
| Chardonnet Laurent | Vice President and Treasurer | Jul 05, 2012 | Sale | $25.11 | 35,700 | 896,405 | 33,148 | Jul 06, 2012, 04:08 PM |
| Chardonnet Laurent | Vice President and Treasurer | Jul 02, 2012 | Option Exercise | $6.95 | 36,666 | 254,829 | 39,700 | Jul 03, 2012, 06:21 PM |
| Chardonnet Laurent | Vice President and Treasurer | Jul 02, 2012 | Sale | $24.15 | 36,666 | 885,484 | 3,034 | Jul 03, 2012, 06:21 PM |
| BAKER JULIAN | Director | Jun 04, 2012 | Option Exercise | $6.66 | 5,000 | 33,300 | 5,000 | Jun 06, 2012, 04:55 PM |
| WHITFIELD ROY A | Director | May 24, 2012 | Sale | $22.27 | 20,000 | 445,400 | 821,082 | May 25, 2012, 04:13 PM |
| BROOKE PAUL A | Director | May 16, 2012 | Option Exercise | $6.66 | 5,000 | 33,300 | 105,000 | May 18, 2012, 04:04 PM |
| BROOKE PAUL A | Director | May 16, 2012 | Sale | $23.55 | 5,000 | 117,750 | 100,000 | May 18, 2012, 04:04 PM |
| ARIKO BARRY A | Director | May 17, 2012 | Option Exercise | $6.66 | 5,000 | 33,300 | 25,834 | May 18, 2012, 04:03 PM |
| SWAIN PAULA J | EVP, Human Resources | May 11, 2012 | Option Exercise | $8.59 | 147,389 | 1,266,780 | 165,450 | May 15, 2012, 05:13 PM |
| SWAIN PAULA J | EVP, Human Resources | May 11, 2012 | Sale | $23.22 | 147,389 | 3,422,372 | 18,061 | May 15, 2012, 05:13 PM |
| Siegel Eric H. | EVP, General Counsel | May 14, 2012 | Option Exercise | $16.09 | 113,332 | 1,823,443 | 57,481 | May 15, 2012, 05:12 PM |
| Siegel Eric H. | EVP, General Counsel | May 14, 2012 | Sale | $23.12 | 114,962 | 2,657,907 | 815 | May 15, 2012, 05:12 PM |
| FRIEDMAN PAUL A | Chief Executive Officer | May 07, 2012 | Option Exercise | $5.97 | 225,000 | 1,343,250 | 534,707 | May 08, 2012, 05:14 PM |
| FRIEDMAN PAUL A | Chief Executive Officer | May 07, 2012 | Sale | $22.56 | 225,000 | 5,076,000 | 309,707 | May 08, 2012, 05:14 PM |
| Chardonnet Laurent | Vice President and Treasurer | May 01, 2012 | Sale | $22.70 | 13,976 | 317,255 | 1,029 | May 01, 2012, 05:10 PM |
| Levy Richard S | EVP, Chief Drug Dev&Medical Of | Apr 27, 2012 | Option Exercise | $8.76 | 30,000 | 262,948 | 30,000 | May 01, 2012, 05:09 PM |
| Levy Richard S | EVP, Chief Drug Dev&Medical Of | Apr 27, 2012 | Sale | $22.95 | 30,000 | 688,500 | 0 | May 01, 2012, 05:09 PM |
| WHITFIELD ROY A | Director | Mar 21, 2012 | Option Exercise | $4.27 | 14,000 | 59,840 | 843,082 | Mar 22, 2012, 04:09 PM |
| WHITFIELD ROY A | Director | Mar 19, 2012 | Option Exercise | $3.27 | 36,000 | 117,760 | 829,082 | Mar 21, 2012, 04:02 PM |
| WHITFIELD ROY A | Director | Feb 17, 2012 | Sale | $17.53 | 20,000 | 350,656 | 810,782 | Feb 21, 2012, 04:22 PM |
| DE SCHUTTER RICHARD U | Director | Jan 31, 2012 | Option Exercise | $5.97 | 65,000 | 388,100 | 160,000 | Jan 31, 2012, 04:08 PM |
| BROOKE PAUL A | Director | Jan 19, 2012 | Buy | $17.86 | 25,000 | 446,500 | 150,000 | Jan 20, 2012, 04:47 PM |
| BROOKE PAUL A | Director | Jan 18, 2012 | Buy | $17.53 | 25,000 | 438,250 | 125,000 | Jan 20, 2012, 04:47 PM |
| 14159 capital (GP), LLC | Director | Jan 13, 2012 | Buy | $16.53 | 5,856 | 96,794 | 355,839 | Jan 17, 2012, 08:43 PM |
| 14159 capital (GP), LLC | Director | Jan 12, 2012 | Buy | $16.26 | 8,769 | 142,615 | 349,983 | Jan 17, 2012, 08:43 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Jan 13, 2012 | Buy | $16.53 | 217,511 | 3,595,234 | 12,430,783 | Jan 17, 2012, 08:43 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Jan 12, 2012 | Buy | $16.26 | 325,728 | 5,297,473 | 12,213,272 | Jan 17, 2012, 08:43 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Dec 08, 2011 | Buy | $13.46 | 222,320 | 2,992,186 | 11,706,343 | Dec 12, 2011, 05:23 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Dec 09, 2011 | Buy | $13.26 | 181,201 | 2,402,409 | 11,887,544 | Dec 12, 2011, 05:23 PM |
| 14159 capital (GP), LLC | Director | Dec 09, 2011 | Buy | $13.26 | 4,862 | 64,462 | 341,214 | Dec 12, 2011, 05:22 PM |
| 14159 capital (GP), LLC | Director | Dec 08, 2011 | Buy | $13.46 | 5,965 | 80,282 | 336,352 | Dec 12, 2011, 05:22 PM |
| 14159 capital (GP), LLC | Director | Dec 07, 2011 | Buy | $13.22 | 3,878 | 51,256 | 330,387 | Dec 07, 2011, 05:58 PM |
| 14159 capital (GP), LLC | Director | Dec 06, 2011 | Buy | $13.53 | 9,057 | 122,526 | 326,509 | Dec 07, 2011, 05:58 PM |
| 14159 capital (GP), LLC | Director | Dec 05, 2011 | Buy | $13.89 | 28,685 | 398,315 | 317,452 | Dec 07, 2011, 05:58 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Dec 07, 2011 | Buy | $13.22 | 144,903 | 1,915,214 | 11,484,023 | Dec 07, 2011, 05:57 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Dec 06, 2011 | Buy | $13.53 | 338,406 | 4,578,060 | 11,339,120 | Dec 07, 2011, 05:57 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Dec 05, 2011 | Buy | $13.89 | 1,071,825 | 14,883,177 | 11,000,714 | Dec 07, 2011, 05:57 PM |
| 14159 capital (GP), LLC | Director | Dec 01, 2011 | Buy | $14.12 | 22,380 | 315,958 | 288,767 | Dec 01, 2011, 04:33 PM |
| 14159 capital (GP), LLC | Director | Nov 29, 2011 | Buy | $12.21 | 28,890 | 352,819 | 266,387 | Dec 01, 2011, 04:33 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Nov 30, 2011 | Buy | $13.44 | 507,911 | 6,826,897 | 9,100,267 | Dec 01, 2011, 04:31 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Nov 29, 2011 | Buy | $12.21 | 1,069,646 | 13,063,037 | 8,592,356 | Dec 01, 2011, 04:31 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Dec 01, 2011 | Buy | $14.12 | 828,622 | 11,698,369 | 9,928,889 | Dec 01, 2011, 04:31 PM |
| DIXON WENDY L | Director | Nov 17, 2011 | Buy | $13.40 | 7,500 | 100,497 | 7,500 | Nov 21, 2011, 04:05 PM |
| Chardonnet Laurent | Vice President and Treasurer | Jun 21, 2011 | Option Exercise | $5.46 | 40,000 | 218,400 | 53,976 | Jun 23, 2011, 04:31 PM |
| Chardonnet Laurent | Vice President and Treasurer | Jun 21, 2011 | Sale | $18.61 | 40,000 | 744,395 | 35,914 | Jun 23, 2011, 04:31 PM |
| WHITFIELD ROY A | Director | Jun 17, 2011 | Sale | $18.02 | 15,498 | 279,334 | 823,880 | Jun 17, 2011, 04:20 PM |
| WHITFIELD ROY A | Director | Jun 16, 2011 | Sale | $18.02 | 4,502 | 81,116 | 832,082 | Jun 17, 2011, 04:20 PM |
| HASTINGS DAVID C | Chief Financial Officer | Jun 09, 2011 | Option Exercise | $5.12 | 100,000 | 512,000 | 108,500 | Jun 10, 2011, 05:06 PM |
| HASTINGS DAVID C | Chief Financial Officer | Jun 09, 2011 | Sale | $17.74 | 100,000 | 1,773,500 | 83,500 | Jun 10, 2011, 05:06 PM |
| SWAIN PAULA J | EVP, Human Resources | May 17, 2011 | Option Exercise | $13.80 | 75,000 | 1,035,000 | 93,061 | May 19, 2011, 04:17 PM |
| SWAIN PAULA J | EVP, Human Resources | May 17, 2011 | Sale | $19.30 | 75,000 | 1,447,636 | 69,760 | May 19, 2011, 04:17 PM |
| WHITFIELD ROY A | Director | May 12, 2011 | Sale | $20.30 | 10,000 | 202,956 | 842,782 | May 13, 2011, 04:35 PM |
| WHITFIELD ROY A | Director | May 11, 2011 | Sale | $20.02 | 10,000 | 200,159 | 850,882 | May 13, 2011, 04:35 PM |
| SCHRECK PATRICIA A | EVP, General Counsel | May 10, 2011 | Option Exercise | $5.46 | 50,000 | 273,000 | 54,500 | May 11, 2011, 04:17 PM |
| SCHRECK PATRICIA A | EVP, General Counsel | May 09, 2011 | Option Exercise | $6.15 | 50,000 | 307,500 | 54,500 | May 11, 2011, 04:17 PM |
| SCHRECK PATRICIA A | EVP, General Counsel | May 09, 2011 | Sale | $19.90 | 50,000 | 995,000 | 4,500 | May 11, 2011, 04:17 PM |
| SCHRECK PATRICIA A | EVP, General Counsel | May 10, 2011 | Sale | $20.58 | 50,000 | 1,029,100 | 44,500 | May 11, 2011, 04:17 PM |
| WHITFIELD ROY A | Director | May 09, 2011 | Sale | $19.79 | 10,000 | 197,885 | 861,682 | May 09, 2011, 04:13 PM |
| WHITFIELD ROY A | Director | May 05, 2011 | Sale | $19.23 | 10,000 | 192,330 | 870,282 | May 09, 2011, 04:13 PM |
| Chardonnet Laurent | Vice President and Treasurer | May 06, 2011 | Sale | $19.55 | 5,343 | 104,456 | 13,976 | May 09, 2011, 04:13 PM |
| METCALF BRIAN W | Chief Drug Discovery Scientist | Apr 11, 2011 | Option Exercise | $5.46 | 100,000 | 546,000 | 166,504 | Apr 13, 2011, 04:09 PM |
| METCALF BRIAN W | Chief Drug Discovery Scientist | Apr 11, 2011 | Sale | $17.41 | 100,000 | 1,741,000 | 116,504 | Apr 13, 2011, 04:09 PM |
| SCHRECK PATRICIA A | EVP, General Counsel | Apr 07, 2011 | Option Exercise | $3.83 | 100,000 | 382,600 | 104,500 | Apr 08, 2011, 04:19 PM |
| SCHRECK PATRICIA A | EVP, General Counsel | Apr 07, 2011 | Sale | $16.50 | 100,000 | 1,650,000 | 4,500 | Apr 08, 2011, 04:19 PM |
| Chardonnet Laurent | Vice President and Treasurer | Apr 08, 2011 | Option Exercise | $3.11 | 25,000 | 77,750 | 36,319 | Apr 08, 2011, 04:18 PM |
| Chardonnet Laurent | Vice President and Treasurer | Apr 08, 2011 | Sale | $17.01 | 25,000 | 425,126 | 15,125 | Apr 08, 2011, 04:18 PM |
| WHITFIELD ROY A | Director | Apr 05, 2011 | Sale | $16.01 | 10,000 | 160,147 | 882,782 | Apr 07, 2011, 04:17 PM |
| WHITFIELD ROY A | Director | Mar 25, 2011 | Sale | $14.65 | 10,000 | 146,528 | 890,382 | Mar 25, 2011, 05:13 PM |
| ARIKO BARRY A | Director | Mar 25, 2011 | Option Exercise | $14.13 | 20,834 | 294,384 | 20,834 | Mar 25, 2011, 05:09 PM |
| METCALF BRIAN W | Chief Drug Discovery Scientist | Mar 18, 2011 | Option Exercise | $10.97 | 160,000 | 1,755,465 | 176,504 | Mar 18, 2011, 04:13 PM |
| METCALF BRIAN W | Chief Drug Discovery Scientist | Mar 16, 2011 | Option Exercise | $6.25 | 50,000 | 312,635 | 116,504 | Mar 18, 2011, 04:13 PM |
| METCALF BRIAN W | Chief Drug Discovery Scientist | Mar 18, 2011 | Sale | $14.27 | 160,000 | 2,282,927 | 118,204 | Mar 18, 2011, 04:13 PM |
| METCALF BRIAN W | Chief Drug Discovery Scientist | Mar 16, 2011 | Sale | $14.25 | 50,000 | 712,500 | 66,504 | Mar 18, 2011, 04:13 PM |
| FRIEDMAN PAUL A | Chief Executive Officer | Feb 23, 2011 | Option Exercise | $8.64 | 20,000 | 172,800 | 309,707 | Feb 24, 2011, 04:12 PM |
| METCALF BRIAN W | Chief Drug Discovery Scientist | Feb 17, 2011 | Option Exercise | $5.97 | 50,000 | 298,500 | 116,504 | Feb 22, 2011, 04:18 PM |
| METCALF BRIAN W | Chief Drug Discovery Scientist | Feb 17, 2011 | Sale | $14.35 | 50,000 | 717,500 | 66,504 | Feb 22, 2011, 04:18 PM |
| Levy Richard S | EVP, Chief Drug Dev&Medical Of | Jan 18, 2011 | Option Exercise | $6.70 | 40,310 | 270,139 | 40,310 | Jan 20, 2011, 04:16 PM |
| Levy Richard S | EVP, Chief Drug Dev&Medical Of | Jan 18, 2011 | Sale | $15.80 | 40,310 | 636,847 | 39,694 | Jan 20, 2011, 04:16 PM |
| WHITFIELD ROY A | Director | Dec 23, 2010 | Sale | $17.02 | 10,000 | 170,228 | 897,982 | Dec 23, 2010, 04:05 PM |
| WHITFIELD ROY A | Director | Dec 22, 2010 | Sale | $17.00 | 10,000 | 170,000 | 906,082 | Dec 23, 2010, 04:05 PM |
| WHITFIELD ROY A | Director | Nov 16, 2010 | Sale | $16.00 | 10,000 | 160,042 | 920,541 | Nov 18, 2010, 04:07 PM |
| WHITFIELD ROY A | Director | Nov 17, 2010 | Sale | $15.90 | 1,000 | 15,900 | 916,082 | Nov 18, 2010, 04:07 PM |
| WHITFIELD ROY A | Director | Oct 25, 2010 | Sale | $16.97 | 29,523 | 501,077 | 956,452 | Oct 26, 2010, 04:53 PM |
| WHITFIELD ROY A | Director | Oct 22, 2010 | Sale | $16.95 | 4,730 | 80,174 | 956,605 | Oct 26, 2010, 04:53 PM |
| 14159 capital (GP), LLC | Director | Sep 23, 2010 | Sale | $14.86 | 5,681 | 84,424 | 237,497 | Sep 23, 2010, 05:49 PM |
| 14159 capital (GP), LLC | Director | Sep 22, 2010 | Sale | $14.71 | 7,180 | 105,631 | 243,178 | Sep 23, 2010, 05:49 PM |
| 14159 capital (GP), LLC | Director | Sep 21, 2010 | Sale | $14.94 | 19,291 | 288,265 | 250,358 | Sep 23, 2010, 05:49 PM |
| Baker Biotech Capital (GP), LLC | Director | Sep 21, 2010 | Sale | $14.94 | 238,230 | 3,559,871 | 3,091,841 | Sep 23, 2010, 05:47 PM |
| Baker Biotech Capital (GP), LLC | Director | Sep 23, 2010 | Sale | $14.86 | 70,150 | 1,042,485 | 2,933,021 | Sep 23, 2010, 05:47 PM |
| Baker Biotech Capital (GP), LLC | Director | Sep 22, 2010 | Sale | $14.71 | 88,670 | 1,304,495 | 3,003,171 | Sep 23, 2010, 05:47 PM |
| Baker Bros. Capital (GP), LLC | Director | Sep 23, 2010 | Sale | $14.86 | 5,722 | 85,033 | 239,258 | Sep 23, 2010, 05:46 PM |
| Baker Bros. Capital (GP), LLC | Director | Sep 22, 2010 | Sale | $14.71 | 7,233 | 106,410 | 244,980 | Sep 23, 2010, 05:46 PM |
| Baker Bros. Capital (GP), LLC | Director | Sep 21, 2010 | Sale | $14.94 | 19,433 | 290,387 | 252,213 | Sep 23, 2010, 05:46 PM |
| Baker / Tisch Capital (GP), LLC | Director | Sep 23, 2010 | Sale | $14.86 | 3,820 | 56,768 | 159,739 | Sep 23, 2010, 05:43 PM |
| Baker / Tisch Capital (GP), LLC | Director | Sep 22, 2010 | Sale | $14.71 | 4,829 | 71,043 | 163,559 | Sep 23, 2010, 05:43 PM |
| Baker / Tisch Capital (GP), LLC | Director | Sep 21, 2010 | Sale | $14.94 | 12,974 | 193,870 | 168,388 | Sep 23, 2010, 05:43 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Sep 23, 2010 | Sale | $14.86 | 179,644 | 2,669,654 | 7,511,046 | Sep 23, 2010, 05:39 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Sep 22, 2010 | Sale | $14.71 | 227,071 | 3,340,623 | 7,690,690 | Sep 23, 2010, 05:39 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Sep 21, 2010 | Sale | $14.94 | 610,072 | 9,116,306 | 7,917,761 | Sep 23, 2010, 05:39 PM |
| Baker Bros. Capital (GP), LLC | Director | Aug 10, 2010 | Sale | $14.00 | 2,812 | 39,364 | 273,502 | Aug 11, 2010, 05:31 PM |
| Baker Bros. Capital (GP), LLC | Director | Aug 09, 2010 | Sale | $14.08 | 9,991 | 140,710 | 280,511 | Aug 11, 2010, 05:31 PM |
| Baker / Tisch Capital (GP), LLC | Director | Aug 10, 2010 | Sale | $14.00 | 1,877 | 26,275 | 182,601 | Aug 11, 2010, 05:24 PM |
| Baker / Tisch Capital (GP), LLC | Director | Aug 09, 2010 | Sale | $14.08 | 6,670 | 93,938 | 187,280 | Aug 11, 2010, 05:24 PM |
| Baker Biotech Capital (GP), LLC | Director | Aug 10, 2010 | Sale | $14.00 | 34,462 | 482,421 | 3,352,822 | Aug 11, 2010, 05:22 PM |
| Baker Biotech Capital (GP), LLC | Director | Aug 09, 2010 | Sale | $14.08 | 122,467 | 1,724,784 | 3,438,734 | Aug 11, 2010, 05:22 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Aug 10, 2010 | Sale | $14.00 | 88,250 | 1,235,380 | 8,586,095 | Aug 11, 2010, 05:21 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | Director | Aug 09, 2010 | Sale | $14.08 | 313,622 | 4,416,947 | 8,806,103 | Aug 11, 2010, 05:21 PM |
| 14159 capital (GP), LLC | Director | Aug 10, 2010 | Sale | $14.00 | 2,789 | 39,042 | 271,491 | Aug 11, 2010, 05:18 PM |
| 14159 capital (GP), LLC | Director | Aug 09, 2010 | Sale | $14.08 | 9,916 | 139,654 | 278,447 | Aug 11, 2010, 05:18 PM |
| SCHRECK PATRICIA A | EVP, General Counsel | Aug 06, 2010 | Option Exercise | $6.15 | 94,960 | 584,004 | 99,460 | Aug 10, 2010, 04:09 PM |
| SCHRECK PATRICIA A | EVP, General Counsel | Aug 06, 2010 | Sale | $13.88 | 94,960 | 1,318,250 | 94,955 | Aug 10, 2010, 04:09 PM |
| Chardonnet Laurent | Vice President and Treasurer | Aug 09, 2010 | Sale | $14.06 | 15,618 | 219,535 | 18,461 | Aug 10, 2010, 04:08 PM |
Load More Insider Transactions
Buy
Sale
Option Exercise
| Owner | Relationship | Date | Value($) |
| Stein Steven H | EVP & Chief Medical Officer | 08/12/2024 | 703,793 |
| Iyengar Vijay K | EVP, GMAPPS | 07/25/2024 | 1,089,970 |
| Stein Steven H | EVP & Chief Medical Officer | 07/15/2024 | 99,909 |
| Tray Thomas | Principal Accounting Officer | 07/15/2024 | 29,941 |
| SWAIN PAULA J | EVP, Human Resources | 07/15/2024 | 35,273 |
| CAGNONI PABLO J | President, R&D | 07/15/2024 | 48,123 |
| Hoppenot Herve | Chairman / CEO | 07/15/2024 | 318,744 |
| Iyengar Vijay K | EVP, GMAPPS | 07/15/2024 | 35,273 |
| Stamoulis Christiana | EVP & Chief Financial Officer | 07/15/2024 | 60,909 |
| Flannelly Barry P | EVP & General Manager US | 07/15/2024 | 71,382 |
| Flannelly Barry P | EVP & General Manager US | 07/16/2024 | 83,832 |
| Flannelly Barry P | EVP & General Manager US | 07/09/2024 | 488,880 |
| Hoppenot Herve | Chairman / CEO | 07/02/2024 | 2,462,491 |
| Flannelly Barry P | EVP & General Manager US | 07/02/2024 | 454,159 |
| Iyengar Vijay K | EVP, GMAPPS | 07/02/2024 | 336,768 |
| Stamoulis Christiana | EVP & Chief Financial Officer | 07/02/2024 | 405,467 |
| Stein Steven H | EVP & Chief Medical Officer | 07/02/2024 | 490,810 |
| SWAIN PAULA J | EVP, Human Resources | 07/02/2024 | 328,151 |
| Tray Thomas | Principal Accounting Officer | 07/02/2024 | 49,813 |
| BAKER BROS. ADVISORS LP | Director | 06/12/2024 | 327,550,980 |
| Flannelly Barry P | EVP & General Manager US | 06/12/2024 | 1,149,840 |
| Schaffert Susanne | Director | 06/12/2024 | 45,075 |
| Tray Thomas | Principal Accounting Officer | 06/06/2024 | 64,389 |
| BAKER BROS. ADVISORS LP | Director | 05/07/2024 | 1,470,300 |
| Clancy Paul J | Director | 03/28/2024 | 22,959 |
| HARRIGAN EDMUND | Director | 03/28/2024 | 23,529 |
| Stamoulis Christiana | EVP & Chief Financial Officer | 02/12/2024 | 22,384 |
| Morrissey Michael James | EVP, Head of Tech. Operations | 01/22/2024 | 6,642 |
| Dickinson Jonathan Elliott | EVP, General Manager, Europe | 01/22/2024 | 6,642 |
| Morrissey Michael James | EVP, Head of Tech. Operations | 01/18/2024 | 694,944 |
| Morrissey Michael James | EVP, Head of Tech. Operations | 01/19/2024 | 7,502 |
| Dickinson Jonathan Elliott | EVP, General Manager, Europe | 01/18/2024 | 496,415 |
| Dickinson Jonathan Elliott | EVP, General Manager, Europe | 01/19/2024 | 7,502 |
| Flannelly Barry P | EVP & General Manager US | 01/17/2024 | 225,939 |
| Tray Thomas | Principal Accounting Officer | 01/17/2024 | 62,771 |
| Dickinson Jonathan Elliott | EVP, General Manager, Europe | 01/17/2024 | 6,209 |
| Dickinson Jonathan Elliott | EVP, General Manager, Europe | 01/16/2024 | 6,195 |
| Morrissey Michael James | EVP, Head of Tech. Operations | 01/17/2024 | 6,209 |
| Morrissey Michael James | EVP, Head of Tech. Operations | 01/16/2024 | 6,195 |
| Stein Steven H | EVP & Chief Medical Officer | 01/03/2024 | 482,481 |
| Iyengar Vijay K | EVP, GMAPPS | 01/02/2024 | 42,705 |
| Clancy Paul J | Director | 12/29/2023 | 25,869 |
| HARRIGAN EDMUND | Director | 12/29/2023 | 26,560 |
| Tray Thomas | Principal Accounting Officer | 12/13/2023 | 66,549 |
| Tray Thomas | Principal Accounting Officer | 12/12/2023 | 12,046 |
| HARRIGAN EDMUND | Director | 09/29/2023 | 22,473 |
| Clancy Paul J | Director | 09/29/2023 | 21,895 |
| SWAIN PAULA J | EVP, Human Resources | 09/01/2023 | 550,283 |
| Stein Steven H | EVP & Chief Medical Officer | 08/01/2023 | 1,361,216 |
| Hoppenot Herve | Chairman / CEO | 07/03/2023 | 2,698,431 |
| Flannelly Barry P | EVP & General Manager US | 07/03/2023 | 391,352 |
| SWAIN PAULA J | EVP, Human Resources | 07/03/2023 | 359,009 |
| Tray Thomas | Principal Accounting Officer | 07/03/2023 | 70,523 |
| Stamoulis Christiana | EVP & Chief Financial Officer | 07/03/2023 | 377,012 |
| Pasquale Maria E | EVP & General Counsel | 07/03/2023 | 525,693 |
| Stein Steven H | EVP & Chief Medical Officer | 07/03/2023 | 524,079 |
| Iyengar Vijay K | EVP, GMAPPS | 07/03/2023 | 385,827 |
| Dhanak Dashyant | EVP & Chief Scientific Officer | 07/03/2023 | 375,212 |
| HARRIGAN EDMUND | Director | 06/30/2023 | 24,278 |
| BAKER BROS. ADVISORS LP | Director | 03/13/2023 | 909,600 |
| Stamoulis Christiana | EVP & Chief Financial Officer | 02/13/2023 | 94,414 |
| Pasquale Maria E | EVP & General Counsel | 01/31/2023 | 59,974 |
| Pasquale Maria E | EVP & General Counsel | 01/31/2023 | 67,416 |
| Pasquale Maria E | EVP & General Counsel | 01/30/2023 | 4,405,224 |
| Pasquale Maria E | EVP & General Counsel | 01/30/2023 | 5,086,569 |
| Iyengar Vijay K | EVP, GMAPPS | 01/26/2023 | 480,340 |
| Iyengar Vijay K | EVP, GMAPPS | 01/26/2023 | 595,000 |
| Dhanak Dashyant | EVP & Chief Scientific Officer | 01/26/2023 | 205,615 |
| Dickinson Jonathan Elliott | EVP, General Manager, Europe | 01/19/2023 | 8,807 |
| Morrissey Michael James | EVP, Head of Tech. Operations | 01/19/2023 | 8,807 |