Intercept Pharmaceuticals Inc. (ICPT) NASDAQ
$11.82 -0.43 (-3.51%)
Market Cap: $510.67M
As of 06/09/23 03:59 PM EDT. Market closed.
Intercept Pharmaceuticals Inc. (ICPT)
NASDAQ
$11.82
-0.43 (-3.51%)
Market Cap: $510.67M
As of 06/09/23 03:59 PM EDT. Market closed.
Intercept is a biopharmaceutical company focused on the development and commercialization of novel therapeutics to treat progressive non-viral liver diseases, including primary biliary cholangitis (PBC) and nonalcoholic steatohepatitis (NASH). Founded in 2002 in New York, Intercept has operations in the United States, Europe and ... read more
Intercept is a biopharmaceutical company focused on the development and commercialization of novel therapeutics to treat progressive non-viral liver diseases, including primary biliary cholangitis (PBC) and nonalcoholic steatohepatitis (NASH). Founded in 2002 in New York, Intercept has operations in the United States, Europe and Canada. read less
COMPANY PROFILE
Sector
Manufacturing
Industry
Pharmaceutical Preparation Manufacturing
CEO Compensation (Base)
$702,000
CEO Compensation (Total)
$4.53M
Sector
Manufacturing
Industry
Pharmaceutical Preparation Manufacturing
Full Time Employees
341
CEO Compensation (Base)
$702,000
CEO Compensation (Total)
$4.53M
Address
.
PRICE CHART FOR INTERCEPT PHARMACEUTICALS INC
From:
To:
NEWS
KEY STATS
Open
$12.23
Previous Close
$12.25
Days Range
$11.92 - $12.51
52 week range
$8.82 - $21.86
Volume
1,047,209
Avg. Volume (30 days)
2,117,467
Market Cap
$510.67M
Dividend Yield
0.00%
P/E
2.47
Shares Outstanding
41,687,084
Open
$12.23
Previous Close
$12.25
Days Range
$11.92 - $12.51
52 week range
$8.82 - $21.86
Volume
1,047,209
Avg. Volume (30 days)
2,117,467
Market Cap
$510.67M
Dividend Yield
0.00%
P/E
2.47
Shares Outstanding
41,687,084
Open in: 
Open in:
INSIDER TRANSACTIONS FOR INTERCEPT PHARMACEUTICALS INC
| Owner | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| Freedberg Jared | General Counsel | May 01, 2023 | Option Exercise | $17.07 | 771 | 13,161 | 57,985 | May 03, 2023, 04:01 PM |
| Saik Andrew | EVP & Chief Financial Officer | Mar 21, 2023 | Option Exercise | $14.19 | 909 | 12,899 | 70,081 | Mar 23, 2023, 04:01 PM |
| Berrey M Michelle | President, R&D & CMO | Mar 14, 2023 | Option Exercise | $15.79 | 1,246 | 19,674 | 82,631 | Mar 16, 2023, 04:07 PM |
| Richardson Linda M | EVP & Chief Commercial Officer | Feb 14, 2023 | Option Exercise | $21.21 | 386 | 8,187 | 43,291 | Feb 16, 2023, 04:01 PM |
| Freedberg Jared | General Counsel | Feb 01, 2023 | Option Exercise | $18.76 | 918 | 17,222 | 58,756 | Feb 03, 2023, 04:01 PM |
| Venezia Rocco | Chief Accounting Officer | Dec 31, 2022 | Option Exercise | $12.37 | 675 | 8,350 | 15,651 | Jan 03, 2023, 04:04 PM |
| Saik Andrew | EVP & Chief Financial Officer | Dec 31, 2022 | Option Exercise | $12.37 | 718 | 8,882 | 56,290 | Jan 03, 2023, 04:04 PM |
| Richardson Linda M | EVP & Chief Commercial Officer | Dec 31, 2022 | Option Exercise | $12.37 | 1,600 | 19,792 | 31,477 | Jan 03, 2023, 04:02 PM |
| Freedberg Jared | General Counsel | Dec 31, 2022 | Option Exercise | $12.37 | 718 | 8,882 | 47,474 | Jan 03, 2023, 04:02 PM |
| Ford David A | Chief Human Resources Officer | Dec 31, 2022 | Option Exercise | $12.37 | 1,777 | 21,981 | 26,638 | Jan 03, 2023, 04:02 PM |
| Durso Jerome Benedict | President & CEO | Dec 31, 2022 | Option Exercise | $12.37 | 7,083 | 87,617 | 104,240 | Jan 03, 2023, 04:01 PM |
| Berrey M Michelle | President, R&D & CMO | Dec 31, 2022 | Option Exercise | $12.37 | 765 | 9,463 | 69,177 | Jan 03, 2023, 04:01 PM |
| Saik Andrew | EVP & Chief Financial Officer | Dec 21, 2022 | Option Exercise | $13.43 | 908 | 12,194 | 57,008 | Dec 23, 2022, 04:03 PM |
| Berrey M Michelle | President, R&D and CMO | Dec 14, 2022 | Option Exercise | $14.94 | 1,246 | 18,615 | 69,942 | Dec 16, 2022, 04:01 PM |
| Freedberg Jared | General Counsel | Nov 01, 2022 | Option Exercise | $15.73 | 771 | 12,128 | 48,192 | Nov 03, 2022, 04:01 PM |
| Saik Andrew | EVP & Chief Financial Officer | Sep 21, 2022 | Option Exercise | $14.85 | 908 | 13,484 | 57,916 | Sep 23, 2022, 04:02 PM |
| Berrey M Michelle | President, R&D and CMO | Sep 14, 2022 | Option Exercise | $17.14 | 1,246 | 21,356 | 71,188 | Sep 16, 2022, 04:02 PM |
| Venezia Rocco | Chief Accounting Officer | Sep 01, 2022 | Option Exercise | $18.06 | 429 | 7,748 | 16,326 | Sep 06, 2022, 04:01 PM |
| Richardson Linda M | EVP & Chief Commercial Officer | Sep 01, 2022 | Option Exercise | $18.06 | 597 | 10,782 | 33,077 | Sep 06, 2022, 04:01 PM |
| Richardson Linda M | EVP & Chief Commercial Officer | Aug 15, 2022 | Option Exercise | $18.19 | 124 | 2,256 | 33,674 | Aug 17, 2022, 04:01 PM |
| Freedberg Jared | General Counsel | Aug 01, 2022 | Option Exercise | $12.21 | 771 | 9,414 | 48,963 | Aug 03, 2022, 04:01 PM |
| BALL BRYAN | Chief Qual. Officer & SVP Ops. | Jul 11, 2022 | Option Exercise | $14.57 | 436 | 6,353 | 25,178 | Jul 13, 2022, 04:01 PM |
| Saik Andrew | EVP & Chief Financial Officer | Jun 21, 2022 | Option Exercise | $12.48 | 3,632 | 45,327 | 58,824 | Jun 23, 2022, 04:01 PM |
| Berrey M Michelle | President, R&D and CMO | Jun 14, 2022 | Option Exercise | $12.10 | 4,984 | 60,306 | 72,434 | Jun 16, 2022, 04:01 PM |
| Richardson Linda M | EVP & Chief Commercial Officer | May 15, 2022 | Option Exercise | $17.88 | 124 | 2,217 | 33,798 | May 17, 2022, 04:01 PM |
| Freedberg Jared | General Counsel | May 01, 2022 | Option Exercise | $15.71 | 771 | 12,112 | 49,734 | May 03, 2022, 04:01 PM |
| BALL BRYAN | Chief Qual. Officer & SVP Ops. | Apr 11, 2022 | Option Exercise | $17.19 | 531 | 9,128 | 25,614 | Apr 13, 2022, 04:01 PM |
| Richardson Linda M | EVP & Chief Commercial Officer | Feb 15, 2022 | Option Exercise | $15.93 | 171 | 2,724 | 33,922 | Feb 17, 2022, 04:01 PM |
| Richardson Linda M | EVP & Chief Commercial Officer | Feb 14, 2022 | Option Exercise | $14.85 | 529 | 7,856 | 34,093 | Feb 15, 2022, 04:48 PM |
| Cawkwell Gail | SVP, Med Affairs, Safety & PV | Feb 12, 2022 | Option Exercise | $15.80 | 320 | 5,056 | 35,740 | Feb 15, 2022, 04:48 PM |
| Freedberg Jared | General Counsel | Feb 01, 2022 | Option Exercise | $16.91 | 4,072 | 68,858 | 50,505 | Feb 03, 2022, 04:04 PM |
| BALL BRYAN | Chief Qual. Officer & SVP Ops. | Jan 11, 2022 | Option Exercise | $16.83 | 2,455 | 41,318 | 22,545 | Jan 13, 2022, 07:04 PM |
| Cawkwell Gail | SVP, Med Affairs, Safety & PV | Dec 31, 2021 | Option Exercise | $16.29 | 2,455 | 39,992 | 29,460 | Jan 04, 2022, 04:14 PM |
| Pruzanski Mark | Director | Nov 30, 2021 | Option Exercise | $17.21 | 6,138 | 105,635 | 622,711 | Dec 02, 2021, 04:05 PM |
| Pruzanski Mark | Director | Nov 30, 2021 | Option Exercise | $17.21 | 3,817 | 65,691 | 618,894 | Dec 02, 2021, 04:05 PM |
| Richardson Linda M | EVP & Chief Commercial Officer | Nov 15, 2021 | Option Exercise | $17.67 | 171 | 3,022 | 25,533 | Nov 17, 2021, 07:00 AM |
| Cawkwell Gail | SVP, Med Affairs, Safety & PV | Nov 12, 2021 | Option Exercise | $19.04 | 319 | 6,074 | 31,915 | Nov 16, 2021, 04:58 PM |
| Pruzanski Mark | Director | Oct 29, 2021 | Option Exercise | $16.86 | 6,138 | 103,487 | 620,390 | Nov 02, 2021, 04:01 PM |
| Pruzanski Mark | Director | Oct 29, 2021 | Option Exercise | $16.86 | 3,817 | 64,355 | 616,573 | Nov 02, 2021, 04:01 PM |
| Venezia Rocco | Chief Accounting Officer | Oct 01, 2021 | Option Exercise | $15.22 | 30 | 457 | 13,705 | Oct 05, 2021, 05:29 PM |
| Ford David A | Chief Human Resources Officer | Oct 01, 2021 | Option Exercise | $15.22 | 92 | 1,400 | 23,527 | Oct 05, 2021, 05:28 PM |
| Durso Jerome Benedict | President & CEO | Oct 01, 2021 | Option Exercise | $15.22 | 289 | 4,399 | 81,564 | Oct 05, 2021, 05:28 PM |
| DeFrancesco Lisa | SVP, IR & Corp. Affairs | Sep 30, 2021 | Option Exercise | $14.85 | 204 | 3,029 | 10,850 | Oct 04, 2021, 05:04 PM |
| Pruzanski Mark | Director | Sep 30, 2021 | Option Exercise | $14.85 | 6,136 | 91,120 | 618,068 | Oct 04, 2021, 05:02 PM |
| Pruzanski Mark | Director | Sep 30, 2021 | Option Exercise | $14.85 | 3,816 | 56,668 | 614,252 | Oct 04, 2021, 05:02 PM |
| Venezia Rocco | Chief Accounting Officer | Sep 01, 2021 | Option Exercise | $15.05 | 524 | 7,886 | 13,735 | Sep 03, 2021, 07:01 PM |
| Richardson Linda M | EVP & Chief Commercial Officer | Sep 01, 2021 | Option Exercise | $15.05 | 820 | 12,341 | 25,704 | Sep 03, 2021, 07:01 PM |
| DeFrancesco Lisa | SVP, IR & Corp. Affairs | Sep 01, 2021 | Option Exercise | $15.05 | 538 | 8,097 | 11,054 | Sep 03, 2021, 07:00 PM |
| Pruzanski Mark | Director | Aug 31, 2021 | Option Exercise | $14.91 | 6,138 | 91,518 | 615,749 | Sep 01, 2021, 07:01 PM |
| Pruzanski Mark | Director | Aug 31, 2021 | Option Exercise | $14.91 | 3,817 | 56,911 | 611,932 | Sep 01, 2021, 07:01 PM |
| Richardson Linda M | EVP & Chief Commercial Officer | Aug 15, 2021 | Option Exercise | $14.92 | 171 | 2,551 | 26,524 | Aug 16, 2021, 07:00 PM |
| Cawkwell Gail | SVP, Med Affairs, Safety & PV | Aug 12, 2021 | Option Exercise | $15.28 | 319 | 4,874 | 32,234 | Aug 13, 2021, 07:01 PM |
| Pruzanski Mark | Director | Jul 30, 2021 | Option Exercise | $17.28 | 6,138 | 106,065 | 613,428 | Aug 02, 2021, 07:00 PM |
| Pruzanski Mark | Director | Jul 30, 2021 | Option Exercise | $17.28 | 3,817 | 65,958 | 609,611 | Aug 02, 2021, 07:00 PM |
| Venezia Rocco | Chief Accounting Officer | Jul 01, 2021 | Option Exercise | $20.47 | 30 | 614 | 14,259 | Jul 02, 2021, 07:01 PM |
| Ford David A | Chief Human Resources Officer | Jul 01, 2021 | Option Exercise | $20.47 | 92 | 1,883 | 23,619 | Jul 02, 2021, 07:01 PM |
| Durso Jerome Benedict | President & CEO | Jul 01, 2021 | Option Exercise | $20.47 | 289 | 5,916 | 81,853 | Jul 02, 2021, 07:00 PM |
| Pruzanski Mark | Director | Jun 30, 2021 | Option Exercise | $19.97 | 6,136 | 122,536 | 611,106 | Jul 01, 2021, 07:01 PM |
| Pruzanski Mark | Director | Jun 30, 2021 | Option Exercise | $19.97 | 3,816 | 76,206 | 607,290 | Jul 01, 2021, 07:01 PM |
| Pruzanski Mark | Director | May 28, 2021 | Option Exercise | $16.63 | 6,138 | 102,075 | 608,787 | Jun 02, 2021, 07:00 PM |
| Pruzanski Mark | Director | May 28, 2021 | Option Exercise | $16.63 | 3,817 | 63,477 | 604,970 | Jun 02, 2021, 07:00 PM |
| Richardson Linda M | EVP & Chief Commercial Officer | May 15, 2021 | Option Exercise | $18.15 | 171 | 3,104 | 26,695 | May 17, 2021, 07:00 PM |
| Cawkwell Gail | SVP, Med Affairs, Safety & PV | May 12, 2021 | Option Exercise | $17.75 | 319 | 5,662 | 32,553 | May 13, 2021, 07:01 PM |
| Ford David A | Chief Human Resources Officer | May 08, 2021 | Option Exercise | $17.15 | 128 | 2,195 | 23,711 | May 11, 2021, 07:00 PM |
| Pruzanski Mark | Director | Apr 30, 2021 | Option Exercise | $19.78 | 6,138 | 121,410 | 506,466 | May 04, 2021, 07:00 PM |
| Pruzanski Mark | Director | Apr 30, 2021 | Option Exercise | $19.78 | 3,817 | 75,500 | 502,649 | May 04, 2021, 07:00 PM |
| Weyer Christian | EVP, Research & Development | Apr 01, 2021 | Option Exercise | $24.28 | 46 | 1,117 | 27,341 | Apr 05, 2021, 07:03 PM |
| Venezia Rocco | Chief Accounting Officer | Apr 01, 2021 | Option Exercise | $24.28 | 29 | 704 | 14,289 | Apr 05, 2021, 07:03 PM |
| Ford David A | Chief Human Resources Officer | Apr 01, 2021 | Option Exercise | $24.28 | 92 | 2,234 | 23,839 | Apr 05, 2021, 07:02 PM |
| Durso Jerome Benedict | President & CEO | Apr 01, 2021 | Option Exercise | $24.28 | 289 | 7,017 | 82,142 | Apr 05, 2021, 07:02 PM |
| Pruzanski Mark | Director | Mar 31, 2021 | Option Exercise | $23.08 | 6,136 | 141,619 | 503,986 | Apr 01, 2021, 07:00 PM |
| Pruzanski Mark | Director | Mar 31, 2021 | Option Exercise | $23.08 | 3,658 | 84,427 | 500,328 | Apr 01, 2021, 07:00 PM |
| AKKARAJU SRINIVAS | Director | Mar 12, 2021 | Buy | $21.29 | 147,000 | 3,129,630 | 640,688 | Mar 12, 2021, 07:51 PM |
| AKKARAJU SRINIVAS | Director | Mar 10, 2021 | Buy | $20.96 | 90,000 | 1,886,622 | 493,688 | Mar 12, 2021, 07:51 PM |
| Pruzanski Mark | Director | Feb 26, 2021 | Option Exercise | $21.66 | 6,138 | 132,949 | 500,591 | Mar 02, 2021, 07:01 PM |
| Pruzanski Mark | Director | Feb 26, 2021 | Option Exercise | $21.66 | 2,741 | 59,370 | 497,850 | Mar 02, 2021, 07:01 PM |
| Weyer Christian | EVP, Research & Development | Feb 27, 2021 | Option Exercise | $21.66 | 357 | 7,733 | 27,387 | Mar 02, 2021, 07:00 PM |
| Durso Jerome Benedict | President & CEO | Feb 23, 2021 | Option Exercise | $28.12 | 319 | 8,970 | 82,431 | Feb 25, 2021, 07:01 PM |
| Cawkwell Gail | SVP, Med Affairs, Safety & PV | Feb 12, 2021 | Option Exercise | $31.32 | 319 | 9,991 | 32,872 | Feb 17, 2021, 07:00 PM |
| Ford David A | Chief Human Resources Officer | Feb 08, 2021 | Option Exercise | $36.04 | 148 | 5,334 | 23,931 | Feb 10, 2021, 07:00 PM |
| Pruzanski Mark | Director | Jan 29, 2021 | Option Exercise | $35.24 | 6,138 | 216,303 | 497,194 | Feb 02, 2021, 07:00 PM |
| Pruzanski Mark | Director | Jan 29, 2021 | Option Exercise | $35.24 | 2,741 | 96,593 | 494,453 | Feb 02, 2021, 07:00 PM |
| Weyer Christian | EVP, Research & Development | Jan 01, 2021 | Option Exercise | $24.70 | 54 | 1,334 | 15,144 | Jan 05, 2021, 07:01 PM |
| Weyer Christian | EVP, Research & Development | Dec 31, 2020 | Option Exercise | $24.70 | 779 | 19,241 | 15,198 | Jan 05, 2021, 07:01 PM |
| Pruzanski Mark | Director | Dec 31, 2020 | Option Exercise | $24.70 | 41,236 | 1,018,529 | 516,753 | Jan 05, 2021, 07:01 PM |
| Pruzanski Mark | Director | Dec 31, 2020 | Option Exercise | $24.70 | 25,065 | 619,106 | 491,688 | Jan 05, 2021, 07:01 PM |
| Pruzanski Mark | Director | Jan 01, 2021 | Option Exercise | $24.70 | 632 | 15,610 | 491,056 | Jan 05, 2021, 07:01 PM |
| Kim Richard J | President US Comm & Strat Mktg | Jan 01, 2021 | Option Exercise | $24.70 | 259 | 6,397 | 19,770 | Jan 05, 2021, 07:01 PM |
| Kim Richard J | President US Comm & Strat Mktg | Dec 31, 2020 | Option Exercise | $24.70 | 799 | 19,735 | 20,029 | Jan 05, 2021, 07:01 PM |
| Kapadia Sandip | CFO and Treasurer | Jan 01, 2021 | Option Exercise | $24.70 | 342 | 8,447 | 25,957 | Jan 05, 2021, 07:01 PM |
| Kapadia Sandip | CFO and Treasurer | Dec 31, 2020 | Option Exercise | $24.70 | 859 | 21,217 | 26,299 | Jan 05, 2021, 07:01 PM |
| Kapadia Sandip | CFO and Treasurer | Jan 05, 2021 | Sale | $24.47 | 2,193 | 53,663 | 23,764 | Jan 05, 2021, 07:01 PM |
| Ford David A | Chief Human Resources Officer | Jan 01, 2021 | Option Exercise | $24.70 | 106 | 2,618 | 12,579 | Jan 05, 2021, 07:01 PM |
| Ford David A | Chief Human Resources Officer | Dec 31, 2020 | Option Exercise | $24.70 | 629 | 15,536 | 12,685 | Jan 05, 2021, 07:01 PM |
| Campagna Jason | Chief Medical Officer | Jan 01, 2021 | Option Exercise | $24.70 | 132 | 3,260 | 7,931 | Jan 05, 2021, 07:00 PM |
| Campagna Jason | Chief Medical Officer | Dec 31, 2020 | Option Exercise | $24.70 | 534 | 13,190 | 8,063 | Jan 05, 2021, 07:00 PM |
| Durso Jerome Benedict | President & CEO | Jan 01, 2021 | Option Exercise | $24.70 | 334 | 8,250 | 36,750 | Jan 05, 2021, 07:00 PM |
| Durso Jerome Benedict | President & CEO | Dec 31, 2020 | Option Exercise | $24.70 | 1,700 | 41,990 | 37,084 | Jan 05, 2021, 07:00 PM |
| Cawkwell Gail | SVP, Med Affairs, Safety & PV | Dec 31, 2020 | Option Exercise | $24.70 | 706 | 17,438 | 20,591 | Jan 05, 2021, 07:00 PM |
| Kapadia Sandip | CFO and Treasurer | Dec 15, 2020 | Sale | $32.78 | 1,763 | 57,791 | 27,158 | Dec 16, 2020, 07:00 PM |
| Weyer Christian | EVP, Research & Development | Nov 27, 2020 | Option Exercise | $37.27 | 357 | 13,305 | 15,977 | Nov 30, 2020, 07:00 PM |
| Durso Jerome Benedict | Chief Operating Officer | Nov 23, 2020 | Option Exercise | $35.47 | 319 | 11,315 | 38,784 | Nov 25, 2020, 07:00 PM |
| Sullivan Ryan T | General Counsel and Secretary | Nov 13, 2020 | Option Exercise | $37.87 | 493 | 18,670 | 24,708 | Nov 16, 2020, 07:00 PM |
| Cawkwell Gail | SVP, Med Affairs, Safety & PV | Nov 12, 2020 | Option Exercise | $38.52 | 319 | 12,288 | 21,297 | Nov 16, 2020, 07:00 PM |
| Ford David A | Chief Human Resources Officer | Nov 08, 2020 | Option Exercise | $28.15 | 128 | 3,603 | 13,314 | Nov 10, 2020, 07:00 PM |
| Campagna Jason | Chief Medical Officer | Oct 01, 2020 | Option Exercise | $42.08 | 112 | 4,713 | 8,597 | Oct 05, 2020, 07:02 PM |
| Durso Jerome Benedict | Chief Operating Officer | Oct 01, 2020 | Option Exercise | $42.08 | 289 | 12,161 | 39,103 | Oct 05, 2020, 07:02 PM |
| Weyer Christian | EVP, Research & Development | Oct 01, 2020 | Option Exercise | $42.08 | 46 | 1,936 | 16,334 | Oct 05, 2020, 07:02 PM |
| Pruzanski Mark | President & CEO | Oct 01, 2020 | Option Exercise | $42.08 | 772 | 32,486 | 475,517 | Oct 05, 2020, 07:01 PM |
| Kim Richard J | President US Comm & Strat Mktg | Oct 01, 2020 | Option Exercise | $42.08 | 223 | 9,384 | 20,828 | Oct 05, 2020, 07:01 PM |
| Kapadia Sandip | CFO and Treasurer | Oct 01, 2020 | Option Exercise | $42.08 | 296 | 12,456 | 28,921 | Oct 05, 2020, 07:00 PM |
| Ford David A | Chief Human Resources Officer | Oct 01, 2020 | Option Exercise | $42.08 | 92 | 3,871 | 13,442 | Oct 05, 2020, 07:00 PM |
| Campagna Jason | Chief Medical Officer | Sep 15, 2020 | Option Exercise | $43.41 | 69 | 2,995 | 8,709 | Sep 17, 2020, 07:00 PM |
| Weyer Christian | EVP, Research & Development | Aug 27, 2020 | Option Exercise | $48.81 | 357 | 17,425 | 16,380 | Aug 31, 2020, 07:00 PM |
| Durso Jerome Benedict | Chief Operating Officer | Aug 23, 2020 | Option Exercise | $48.21 | 319 | 15,379 | 39,392 | Aug 25, 2020, 07:00 PM |
| Campagna Jason | Chief Medical Officer | Aug 18, 2020 | Sale | $47.44 | 1,192 | 56,543 | 8,778 | Aug 20, 2020, 07:00 PM |
| Genextra S.p.A. | 10% Owner | Aug 17, 2020 | Sale | $47.07 | 1,362,400 | 64,123,099 | 5,235,512 | Aug 17, 2020, 08:13 PM |
| Genextra S.p.A. | 10% Owner | Aug 14, 2020 | Sale | $50.55 | 54,600 | 2,760,112 | 5,362,400 | Aug 17, 2020, 08:13 PM |
| Genextra S.p.A. | 10% Owner | Aug 13, 2020 | Sale | $52.60 | 83,000 | 4,365,451 | 5,417,000 | Aug 17, 2020, 08:13 PM |
| Micheli Francesco | 10% Owner | Aug 13, 2020 | Sale | $52.60 | 83,000 | 4,365,451 | 5,417,000 | Aug 17, 2020, 08:10 PM |
| Micheli Francesco | 10% Owner | Aug 17, 2020 | Sale | $47.07 | 1,362,400 | 64,123,099 | 5,235,512 | Aug 17, 2020, 08:10 PM |
| Micheli Francesco | 10% Owner | Aug 14, 2020 | Sale | $50.55 | 54,600 | 2,760,112 | 5,362,400 | Aug 17, 2020, 08:10 PM |
| Fundaro Paolo | Director | Aug 17, 2020 | Sale | $47.07 | 1,362,400 | 64,123,099 | 5,235,512 | Aug 17, 2020, 08:06 PM |
| Fundaro Paolo | Director | Aug 14, 2020 | Sale | $50.55 | 54,600 | 2,760,112 | 5,362,400 | Aug 17, 2020, 08:06 PM |
| Fundaro Paolo | Director | Aug 13, 2020 | Sale | $52.60 | 83,000 | 4,365,451 | 5,417,000 | Aug 17, 2020, 08:06 PM |
| Sullivan Ryan T | General Counsel and Secretary | Aug 13, 2020 | Option Exercise | $51.86 | 493 | 25,567 | 25,201 | Aug 14, 2020, 07:01 PM |
| Cawkwell Gail | SVP, Med Affairs, Safety & PV | Aug 12, 2020 | Option Exercise | $53.44 | 319 | 17,047 | 21,616 | Aug 14, 2020, 07:00 PM |
| Ford David A | Chief Human Resources Officer | Aug 08, 2020 | Option Exercise | $48.75 | 128 | 6,240 | 13,534 | Aug 11, 2020, 07:00 PM |
| Weyer Christian | EVP, Research & Development | Jul 01, 2020 | Option Exercise | $46.52 | 46 | 2,140 | 16,737 | Jul 06, 2020, 07:03 PM |
| Pruzanski Mark | President & CEO | Jul 01, 2020 | Option Exercise | $46.52 | 772 | 35,913 | 476,289 | Jul 06, 2020, 07:02 PM |
| Kim Richard J | President US Comm & Strat Mktg | Jul 01, 2020 | Option Exercise | $46.52 | 224 | 10,420 | 21,051 | Jul 06, 2020, 07:02 PM |
| Kapadia Sandip | CFO and Treasurer | Jul 01, 2020 | Option Exercise | $46.52 | 615 | 28,610 | 29,217 | Jul 06, 2020, 07:01 PM |
| Ford David A | Chief Human Resources Officer | Jul 01, 2020 | Option Exercise | $46.52 | 92 | 4,280 | 13,662 | Jul 06, 2020, 07:01 PM |
| Campagna Jason | Chief Medical Officer | Jul 01, 2020 | Option Exercise | $46.52 | 112 | 5,210 | 9,970 | Jul 06, 2020, 07:00 PM |
| Bright Lisa | President, International | Jul 01, 2020 | Option Exercise | $46.52 | 301 | 14,003 | 22,012 | Jul 06, 2020, 07:00 PM |
| Durso Jerome Benedict | Chief Operating Officer | Jul 01, 2020 | Option Exercise | $46.52 | 289 | 13,444 | 39,711 | Jul 06, 2020, 07:00 PM |
| Campagna Jason | Chief Medical Officer | Jun 15, 2020 | Option Exercise | $77.40 | 70 | 5,418 | 10,082 | Jun 17, 2020, 07:00 PM |
| Weyer Christian | EVP, Research & Development | May 27, 2020 | Option Exercise | $74.43 | 357 | 26,572 | 16,783 | May 29, 2020, 07:00 PM |
| Durso Jerome Benedict | Chief Operating Officer | May 23, 2020 | Option Exercise | $80.51 | 319 | 25,683 | 40,000 | May 27, 2020, 07:00 PM |
| Fundaro Paolo | Director | May 13, 2020 | Sale | $84.60 | 595,578 | 50,385,898 | 5,500,000 | May 15, 2020, 05:19 PM |
| Micheli Francesco | 10% Owner | May 13, 2020 | Sale | $84.60 | 595,578 | 50,385,898 | 5,500,000 | May 15, 2020, 04:55 PM |
| Genextra S.p.A. | 10% Owner | May 13, 2020 | Sale | $84.60 | 595,578 | 50,385,898 | 5,500,000 | May 15, 2020, 04:46 PM |
| Sullivan Ryan T | General Counsel and Secretary | May 13, 2020 | Option Exercise | $85.08 | 493 | 41,944 | 25,694 | May 14, 2020, 07:01 PM |
| Cawkwell Gail | SVP, Med Affairs, Safety & PV | May 12, 2020 | Option Exercise | $89.05 | 319 | 28,407 | 21,935 | May 14, 2020, 07:00 PM |
| Ford David A | Chief Human Resources Officer | May 08, 2020 | Option Exercise | $87.80 | 128 | 11,238 | 13,754 | May 12, 2020, 07:02 PM |
| Weyer Christian | EVP, Research & Development | Apr 27, 2020 | Sale | $85.95 | 181 | 15,557 | 17,140 | Apr 29, 2020, 07:00 PM |
| Ford David A | Chief Human Resources Officer | Apr 09, 2020 | Sale | $70.00 | 58 | 4,060 | 13,882 | Apr 10, 2020, 07:00 PM |
| Weyer Christian | EVP, Research & Development | Apr 01, 2020 | Option Exercise | $58.40 | 46 | 2,686 | 17,321 | Apr 03, 2020, 07:08 PM |
| Pruzanski Mark | President & CEO | Apr 01, 2020 | Option Exercise | $58.40 | 568 | 33,171 | 477,061 | Apr 03, 2020, 07:06 PM |
| Kim Richard J | President US Comm & Strat Mktg | Apr 01, 2020 | Option Exercise | $58.40 | 223 | 13,023 | 21,275 | Apr 03, 2020, 07:06 PM |
| Kapadia Sandip | CFO and Treasurer | Apr 01, 2020 | Option Exercise | $58.40 | 615 | 35,916 | 29,832 | Apr 03, 2020, 07:05 PM |
| Ford David A | Chief Human Resources Officer | Apr 01, 2020 | Option Exercise | $58.40 | 92 | 5,373 | 13,940 | Apr 03, 2020, 07:02 PM |
| Durso Jerome Benedict | Chief Operating Officer | Apr 01, 2020 | Option Exercise | $58.40 | 289 | 16,878 | 40,319 | Apr 03, 2020, 07:02 PM |
| Campagna Jason | Chief Medical Officer | Apr 01, 2020 | Option Exercise | $58.40 | 112 | 6,541 | 10,152 | Apr 03, 2020, 07:02 PM |
| Bright Lisa | President, International | Apr 01, 2020 | Option Exercise | $58.40 | 301 | 17,578 | 22,313 | Apr 03, 2020, 07:01 PM |
| Campagna Jason | Chief Medical Officer | Mar 15, 2020 | Option Exercise | $71.82 | 69 | 4,956 | 10,264 | Mar 17, 2020, 07:00 PM |
| Weyer Christian | EVP, Research & Development | Feb 27, 2020 | Option Exercise | $85.39 | 357 | 30,484 | 17,480 | Feb 28, 2020, 07:00 PM |
| Weyer Christian | EVP, Research & Development | Feb 27, 2020 | Sale | $87.62 | 113 | 9,901 | 17,367 | Feb 28, 2020, 07:00 PM |
| Durso Jerome Benedict | Chief Operating Officer | Feb 23, 2020 | Option Exercise | $94.99 | 319 | 30,302 | 40,608 | Feb 24, 2020, 07:00 PM |
| Campagna Jason | Chief Medical Officer | Feb 19, 2020 | Option Exercise | $96.24 | 170 | 16,361 | 10,333 | Feb 21, 2020, 07:00 PM |
| Sullivan Ryan T | General Counsel and Secretary | Feb 13, 2020 | Option Exercise | $94.69 | 493 | 46,682 | 26,187 | Feb 14, 2020, 07:01 PM |
| Cawkwell Gail | SVP, Med Affairs, Safety & PV | Feb 12, 2020 | Option Exercise | $96.74 | 319 | 30,860 | 22,254 | Feb 14, 2020, 07:00 PM |
| Ford David A | Chief Human Resources Officer | Feb 08, 2020 | Option Exercise | $95.17 | 148 | 14,085 | 14,032 | Feb 11, 2020, 07:00 PM |
| Weyer Christian | EVP, Research & Development | Jan 27, 2020 | Sale | $94.04 | 723 | 67,991 | 17,837 | Jan 27, 2020, 07:01 PM |
| Campagna Jason | Chief Medical Officer | Jan 07, 2020 | Sale | $113.02 | 732 | 82,731 | 6,303 | Jan 08, 2020, 07:00 PM |
| Durso Jerome Benedict | Chief Operating Officer | Jan 01, 2020 | Option Exercise | $123.92 | 334 | 41,389 | 30,327 | Jan 03, 2020, 07:00 PM |
| Durso Jerome Benedict | Chief Operating Officer | Dec 31, 2019 | Option Exercise | $123.92 | 1,151 | 142,632 | 30,661 | Jan 03, 2020, 07:00 PM |
| Campagna Jason | Chief Medical Officer | Dec 31, 2019 | Option Exercise | $123.92 | 259 | 32,095 | 7,185 | Jan 03, 2020, 07:00 PM |
| Bright Lisa | President, International | Dec 31, 2019 | Option Exercise | $123.92 | 388 | 48,081 | 18,344 | Jan 03, 2020, 07:00 PM |
| Kapadia Sandip | CFO and Treasurer | Jan 01, 2020 | Option Exercise | $123.92 | 669 | 82,902 | 24,847 | Jan 03, 2020, 07:00 PM |
| Pruzanski Mark | President & CEO | Jan 01, 2020 | Option Exercise | $123.92 | 1,166 | 144,491 | 466,829 | Jan 03, 2020, 07:00 PM |
| Kapadia Sandip | CFO and Treasurer | Dec 31, 2019 | Option Exercise | $123.92 | 551 | 68,280 | 25,516 | Jan 03, 2020, 07:00 PM |
| Pruzanski Mark | President & CEO | Dec 31, 2019 | Option Exercise | $123.92 | 1,131 | 140,154 | 467,995 | Jan 03, 2020, 07:00 PM |
| Kim Richard J | President US Comm & Strat Mktg | Jan 01, 2020 | Option Exercise | $123.92 | 309 | 38,291 | 16,098 | Jan 03, 2020, 07:00 PM |
| Kim Richard J | President US Comm & Strat Mktg | Dec 31, 2019 | Option Exercise | $123.92 | 340 | 42,133 | 16,407 | Jan 03, 2020, 07:00 PM |
| Campagna Jason | Chief Medical Officer | Jan 01, 2020 | Option Exercise | $123.92 | 150 | 18,588 | 7,035 | Jan 03, 2020, 07:00 PM |
| Bright Lisa | President, International | Jan 01, 2020 | Option Exercise | $123.92 | 530 | 65,678 | 17,814 | Jan 03, 2020, 07:00 PM |
| Pruzanski Mark | President & CEO | Dec 31, 2019 | Option Exercise | $21.50 | 100 | 2,150 | 469,226 | Jan 03, 2020, 07:00 PM |
| Pruzanski Mark | President & CEO | Dec 31, 2019 | Sale | $125.00 | 100 | 12,500 | 469,126 | Jan 03, 2020, 07:00 PM |
| Weyer Christian | EVP, Research & Development | Dec 31, 2019 | Option Exercise | $123.92 | 364 | 45,107 | 13,814 | Jan 03, 2020, 07:00 PM |
| Sullivan Ryan T | General Counsel and Secretary | Dec 31, 2019 | Option Exercise | $123.92 | 809 | 100,251 | 21,080 | Jan 03, 2020, 07:00 PM |
| Ford David A | Chief Human Resources Officer | Jan 01, 2020 | Option Exercise | $123.92 | 106 | 13,136 | 10,839 | Jan 03, 2020, 07:00 PM |
| Ford David A | Chief Human Resources Officer | Dec 31, 2019 | Option Exercise | $123.92 | 323 | 40,026 | 10,945 | Jan 03, 2020, 07:00 PM |
| Cawkwell Gail | SVP, Med Affairs, Safety & PV | Dec 31, 2019 | Option Exercise | $123.92 | 349 | 43,248 | 18,373 | Jan 03, 2020, 07:00 PM |
| Weyer Christian | EVP, Research & Development | Jan 01, 2020 | Option Exercise | $123.92 | 54 | 6,692 | 13,760 | Jan 03, 2020, 07:00 PM |
| Cawkwell Gail | SVP, Med Affairs, Safety & PV | Dec 31, 2019 | Option Exercise | $54.63 | 262 | 14,313 | 18,984 | Jan 03, 2020, 07:00 PM |
| Ford David A | Chief Human Resources Officer | Jan 03, 2019 | Sale | $117.16 | 259 | 30,344 | 10,580 | Jan 03, 2020, 07:00 PM |
| Cawkwell Gail | SVP, Med Affairs, Safety & PV | Dec 31, 2019 | Sale | $125.00 | 262 | 32,750 | 18,722 | Jan 03, 2020, 07:00 PM |
| Weyer Christian | EVP, Research & Development | Dec 27, 2019 | Option Exercise | $59.08 | 470 | 27,766 | 15,759 | Dec 30, 2019, 07:01 PM |
| Weyer Christian | EVP, Research & Development | Dec 27, 2019 | Sale | $123.24 | 1,581 | 194,842 | 14,178 | Dec 30, 2019, 07:01 PM |
| Pruzanski Mark | President & CEO | Dec 26, 2019 | Option Exercise | $21.50 | 417 | 8,966 | 469,543 | Dec 30, 2019, 07:00 PM |
| Pruzanski Mark | President & CEO | Dec 26, 2019 | Sale | $125.00 | 417 | 52,125 | 469,126 | Dec 30, 2019, 07:00 PM |
| Cawkwell Gail | SVP, Med Affairs, Safety & PV | Dec 26, 2019 | Option Exercise | $54.63 | 54 | 2,950 | 18,776 | Dec 30, 2019, 07:00 PM |
| Cawkwell Gail | SVP, Med Affairs, Safety & PV | Dec 26, 2019 | Sale | $125.00 | 54 | 6,750 | 18,722 | Dec 30, 2019, 07:00 PM |
| Campagna Jason | Chief Medical Officer | Dec 19, 2019 | Sale | $119.45 | 154 | 18,395 | 7,444 | Dec 20, 2019, 07:00 PM |
| Campagna Jason | Chief Medical Officer | Dec 15, 2019 | Option Exercise | $114.16 | 80 | 9,133 | 7,598 | Dec 17, 2019, 07:00 PM |
| Cawkwell Gail | SVP, Med Affairs, Safety & PV | Dec 03, 2019 | Option Exercise | $54.63 | 80 | 4,370 | 18,722 | Dec 05, 2019, 07:00 PM |
| Weyer Christian | EVP, Research & Development | Nov 27, 2019 | Option Exercise | $109.16 | 357 | 38,970 | 15,289 | Dec 02, 2019, 07:00 PM |
| Weyer Christian | EVP, Research & Development | Nov 27, 2019 | Option Exercise | $59.10 | 927 | 54,784 | 16,686 | Dec 02, 2019, 07:00 PM |
| Weyer Christian | EVP, Research & Development | Nov 27, 2019 | Sale | $101.65 | 1,040 | 105,716 | 15,646 | Dec 02, 2019, 07:00 PM |
| Weyer Christian | EVP, Research & Development | Nov 26, 2019 | Option Exercise | $59.11 | 4,373 | 258,491 | 20,132 | Nov 27, 2019, 07:00 PM |
| Weyer Christian | EVP, Research & Development | Nov 25, 2019 | Option Exercise | $59.10 | 1,855 | 109,628 | 17,614 | Nov 27, 2019, 07:00 PM |
| Weyer Christian | EVP, Research & Development | Nov 25, 2019 | Sale | $100.00 | 1,855 | 185,500 | 15,759 | Nov 27, 2019, 07:00 PM |
| Weyer Christian | EVP, Research & Development | Nov 26, 2019 | Sale | $100.00 | 4,373 | 437,300 | 15,759 | Nov 27, 2019, 07:00 PM |
| Pruzanski Mark | President & CEO | Nov 26, 2019 | Option Exercise | $14.30 | 35,437 | 506,770 | 504,563 | Nov 27, 2019, 07:00 PM |
| Pruzanski Mark | President & CEO | Nov 25, 2019 | Option Exercise | $8.67 | 14,563 | 126,213 | 483,689 | Nov 27, 2019, 07:00 PM |
| Pruzanski Mark | President & CEO | Nov 26, 2019 | Sale | $100.00 | 35,437 | 3,543,700 | 469,126 | Nov 27, 2019, 07:00 PM |
| Pruzanski Mark | President & CEO | Nov 25, 2019 | Sale | $100.00 | 14,563 | 1,456,300 | 469,126 | Nov 27, 2019, 07:00 PM |
| Durso Jerome Benedict | Chief Operating Officer | Nov 23, 2019 | Option Exercise | $88.89 | 460 | 40,889 | 31,812 | Nov 26, 2019, 07:00 PM |
| Weyer Christian | EVP, Research & Development | Nov 19, 2019 | Sale | $85.00 | 1,550 | 131,750 | 15,759 | Nov 19, 2019, 07:01 PM |
| Sullivan Ryan T | General Counsel and Secretary | Nov 19, 2019 | Option Exercise | $53.41 | 8,325 | 444,638 | 34,043 | Nov 19, 2019, 07:00 PM |
| Sullivan Ryan T | General Counsel and Secretary | Nov 19, 2019 | Sale | $85.00 | 12,154 | 1,033,090 | 25,718 | Nov 19, 2019, 07:00 PM |
| Sullivan Ryan T | General Counsel and Secretary | Nov 13, 2019 | Option Exercise | $83.92 | 711 | 59,667 | 25,718 | Nov 15, 2019, 07:02 PM |
| Sullivan Ryan T | General Counsel and Secretary | Nov 13, 2019 | Option Exercise | $53.41 | 500 | 26,705 | 26,929 | Nov 15, 2019, 07:02 PM |
| Sullivan Ryan T | General Counsel and Secretary | Nov 13, 2019 | Sale | $85.00 | 500 | 42,500 | 26,429 | Nov 15, 2019, 07:02 PM |
| Weyer Christian | EVP, Research & Development | Nov 13, 2019 | Sale | $85.00 | 946 | 80,410 | 17,309 | Nov 15, 2019, 07:01 PM |
| Cawkwell Gail | SVP, Med Affairs, Safety & PV | Nov 12, 2019 | Option Exercise | $83.02 | 319 | 26,483 | 18,642 | Nov 14, 2019, 07:00 PM |
| Ford David A | Chief Human Resources Officer | Nov 08, 2019 | Option Exercise | $82.76 | 128 | 10,593 | 11,268 | Nov 12, 2019, 07:00 PM |
| Bright Lisa | President, International | Oct 29, 2019 | Sale | $75.00 | 595 | 44,625 | 18,732 | Oct 31, 2019, 07:00 PM |
| Ford David A | Chief Human Resources Officer | Oct 23, 2019 | Sale | $70.00 | 58 | 4,060 | 11,396 | Oct 25, 2019, 07:00 PM |
| Ford David A | Chief Human Resources Officer | Oct 01, 2019 | Option Exercise | $65.87 | 92 | 6,060 | 11,454 | Oct 03, 2019, 07:04 PM |
| Durso Jerome Benedict | Chief Operating Officer | Oct 01, 2019 | Option Exercise | $65.87 | 417 | 27,468 | 32,272 | Oct 03, 2019, 07:03 PM |
| Bright Lisa | President, International | Oct 01, 2019 | Option Exercise | $65.87 | 530 | 34,911 | 19,327 | Oct 03, 2019, 07:03 PM |
| Weyer Christian | EVP, Research & Development | Oct 01, 2019 | Option Exercise | $65.87 | 46 | 3,030 | 18,255 | Oct 03, 2019, 07:02 PM |
| Pruzanski Mark | President & CEO | Oct 01, 2019 | Option Exercise | $65.87 | 1,547 | 101,901 | 469,126 | Oct 03, 2019, 07:02 PM |
| Kim Richard J | President US Comm & Strat Mktg | Oct 01, 2019 | Option Exercise | $65.87 | 267 | 17,587 | 16,747 | Oct 03, 2019, 07:01 PM |
| Kapadia Sandip | CFO and Treasurer | Oct 01, 2019 | Option Exercise | $65.87 | 626 | 41,235 | 26,067 | Oct 03, 2019, 07:00 PM |
| Ford David A | Chief Human Resources Officer | Sep 16, 2019 | Sale | $70.00 | 800 | 56,000 | 11,546 | Sep 18, 2019, 07:00 PM |
| AKKARAJU SRINIVAS | Director | Aug 28, 2019 | Buy | $60.32 | 5,207 | 314,086 | 403,688 | Aug 30, 2019, 02:32 PM |
| Weyer Christian | EVP, Research & Development | Aug 27, 2019 | Option Exercise | $60.50 | 357 | 21,599 | 18,301 | Aug 29, 2019, 07:00 PM |
| Durso Jerome Benedict | Chief Operating Officer | Aug 23, 2019 | Option Exercise | $60.90 | 319 | 19,427 | 32,689 | Aug 27, 2019, 07:00 PM |
| AKKARAJU SRINIVAS | Director | Aug 22, 2019 | Buy | $64.30 | 1,180 | 75,874 | 398,481 | Aug 23, 2019, 08:14 PM |
| AKKARAJU SRINIVAS | Director | Aug 21, 2019 | Buy | $67.12 | 29,000 | 1,946,480 | 397,301 | Aug 23, 2019, 08:14 PM |
| AKKARAJU SRINIVAS | Director | Aug 20, 2019 | Buy | $65.85 | 37,604 | 2,476,223 | 368,301 | Aug 23, 2019, 08:14 PM |
| AKKARAJU SRINIVAS | Director | Aug 22, 2019 | Option Exercise | $64.30 | 1,180 | 75,874 | 398,481 | Aug 22, 2019, 07:53 PM |
| AKKARAJU SRINIVAS | Director | Aug 21, 2019 | Option Exercise | $67.12 | 29,000 | 1,946,480 | 397,301 | Aug 22, 2019, 07:53 PM |
| AKKARAJU SRINIVAS | Director | Aug 20, 2019 | Option Exercise | $65.85 | 37,604 | 2,476,223 | 368,301 | Aug 22, 2019, 07:53 PM |
| Sullivan Ryan T | General Counsel and Secretary | Aug 13, 2019 | Option Exercise | $66.03 | 689 | 45,495 | 26,429 | Aug 14, 2019, 07:01 PM |
| Cawkwell Gail | SVP, Med Affairs, Safety & PV | Aug 12, 2019 | Option Exercise | $65.89 | 319 | 21,019 | 18,961 | Aug 14, 2019, 07:01 PM |
| Ford David A | Chief Human Resources Officer | Aug 08, 2019 | Option Exercise | $66.05 | 128 | 8,454 | 12,346 | Aug 09, 2019, 07:00 PM |
| Kim Richard J | President US Comm & Strat Mktg | Jul 13, 2019 | Option Exercise | $69.71 | 111 | 7,738 | 17,014 | Jul 15, 2019, 07:00 PM |
| Weyer Christian | EVP, Research & Development | Jul 01, 2019 | Option Exercise | $79.17 | 46 | 3,642 | 18,658 | Jul 03, 2019, 05:00 PM |
| Kapadia Sandip | CFO and Treasurer | Jul 01, 2019 | Option Exercise | $79.17 | 615 | 48,690 | 26,693 | Jul 03, 2019, 05:00 PM |
| Durso Jerome Benedict | Chief Operating Officer | Jul 01, 2019 | Option Exercise | $79.17 | 289 | 22,880 | 33,008 | Jul 03, 2019, 05:00 PM |
| Kim Richard J | President US Comm & Strat Mktg | Jul 01, 2019 | Option Exercise | $79.17 | 268 | 21,218 | 17,125 | Jul 03, 2019, 05:00 PM |
| Ford David A | Chief Human Resources Officer | Jul 01, 2019 | Option Exercise | $79.17 | 92 | 7,284 | 12,474 | Jul 03, 2019, 05:00 PM |
| Pruzanski Mark | President & CEO | Jul 01, 2019 | Option Exercise | $79.17 | 1,548 | 122,555 | 470,673 | Jul 03, 2019, 05:00 PM |
| Bright Lisa | President, International | Jul 01, 2019 | Option Exercise | $79.17 | 530 | 41,960 | 20,452 | Jul 03, 2019, 05:00 PM |
| Bright Lisa | President, International | Jul 03, 2019 | Sale | $78.66 | 595 | 46,803 | 19,857 | Jul 03, 2019, 05:00 PM |
| Weyer Christian | EVP, Research & Development | May 27, 2019 | Option Exercise | $87.83 | 357 | 31,355 | 18,704 | May 29, 2019, 07:00 PM |
| Durso Jerome Benedict | Chief Operating Officer | May 23, 2019 | Option Exercise | $85.51 | 460 | 39,335 | 33,297 | May 28, 2019, 07:00 PM |
| Fundaro Paolo | Director | May 20, 2019 | Option Exercise | $15.24 | 6,749 | 102,887 | 17,863 | May 22, 2019, 07:00 PM |
| AKKARAJU SRINIVAS | Director | May 14, 2019 | Option Exercise | $83.50 | 119,760 | 9,999,960 | 330,697 | May 14, 2019, 07:00 PM |
| Sullivan Ryan T | General Counsel and Secretary | May 13, 2019 | Option Exercise | $83.73 | 711 | 59,532 | 27,118 | May 14, 2019, 07:00 PM |
| Cawkwell Gail | SVP, Med Affairs, Safety & PV | May 12, 2019 | Option Exercise | $86.66 | 319 | 27,645 | 19,280 | May 14, 2019, 07:00 PM |
| Benatti Luca | Director | May 14, 2019 | Buy | $83.50 | 1,200 | 100,200 | 7,556 | May 14, 2019, 07:00 PM |
| Ford David A | Chief Human Resources Officer | May 08, 2019 | Option Exercise | $87.57 | 128 | 11,209 | 12,566 | May 10, 2019, 07:00 PM |
| Shapiro David | Chief Medical Officer | May 01, 2019 | Option Exercise | $31.90 | 2,000 | 63,800 | 41,499 | May 03, 2019, 07:00 PM |
| Shapiro David | Chief Medical Officer | May 01, 2019 | Sale | $86.28 | 2,000 | 172,560 | 39,499 | May 03, 2019, 07:00 PM |
| AKKARAJU SRINIVAS | Director | Apr 25, 2019 | Option Exercise | $24.47 | 3,500 | 85,660 | 19,956 | Apr 29, 2019, 07:00 PM |
| Cawkwell Gail | SVP, Med Affairs, Safety & PV | Apr 18, 2019 | Option Exercise | $54.63 | 1,750 | 95,603 | 19,599 | Apr 22, 2019, 07:01 PM |
| Shapiro David | Chief Medical Officer | Apr 15, 2019 | Option Exercise | $31.90 | 2,000 | 63,800 | 41,499 | Apr 16, 2019, 07:01 PM |
| Shapiro David | Chief Medical Officer | Apr 15, 2019 | Sale | $95.00 | 2,000 | 190,000 | 39,499 | Apr 16, 2019, 07:01 PM |
| Kim Richard J | President US Comm & Strat Mktg | Apr 13, 2019 | Option Exercise | $95.21 | 77 | 7,331 | 17,393 | Apr 16, 2019, 07:00 PM |
| Weyer Christian | EVP, Research & Development | Apr 01, 2019 | Option Exercise | $111.50 | 46 | 5,129 | 19,061 | Apr 03, 2019, 07:01 PM |
| Bright Lisa | President, International | Apr 01, 2019 | Option Exercise | $111.50 | 531 | 59,207 | 21,576 | Apr 03, 2019, 07:01 PM |
| Durso Jerome Benedict | Chief Operating Officer | Apr 01, 2019 | Option Exercise | $111.50 | 289 | 32,224 | 33,757 | Apr 03, 2019, 07:01 PM |
| Bright Lisa | President, International | Apr 03, 2019 | Sale | $115.01 | 594 | 68,316 | 20,982 | Apr 03, 2019, 07:01 PM |
| Ford David A | Chief Human Resources Officer | Apr 01, 2019 | Option Exercise | $111.50 | 92 | 10,258 | 12,694 | Apr 03, 2019, 07:00 PM |
| Pruzanski Mark | President & CEO | Apr 01, 2019 | Option Exercise | $111.50 | 1,547 | 172,491 | 472,221 | Apr 03, 2019, 07:00 PM |
| Shapiro David | Chief Medical Officer | Apr 01, 2019 | Option Exercise | $111.50 | 482 | 53,743 | 40,061 | Apr 03, 2019, 07:00 PM |
| Kapadia Sandip | CFO and Treasurer | Apr 01, 2019 | Option Exercise | $111.50 | 615 | 68,573 | 27,308 | Apr 03, 2019, 07:00 PM |
| Kim Richard J | President US Comm & Strat Mktg | Apr 01, 2019 | Option Exercise | $111.50 | 267 | 29,771 | 17,470 | Apr 03, 2019, 07:00 PM |
| Shapiro David | Chief Medical Officer | Apr 03, 2019 | Sale | $115.01 | 562 | 64,636 | 39,499 | Apr 03, 2019, 07:00 PM |
| Fundaro Paolo | Director | Mar 29, 2019 | Sale | $107.45 | 2,171 | 233,272 | 11,114 | Mar 29, 2019, 07:00 PM |
| Weyer Christian | EVP, Research & Development | Feb 27, 2019 | Option Exercise | $92.76 | 364 | 33,765 | 19,440 | Mar 01, 2019, 07:00 PM |
| Weyer Christian | EVP, Research & Development | Mar 01, 2019 | Sale | $103.16 | 333 | 34,352 | 19,107 | Mar 01, 2019, 07:00 PM |
| Shapiro David | Chief Medical Officer | Mar 01, 2019 | Option Exercise | $31.90 | 2,000 | 63,800 | 42,543 | Mar 01, 2019, 07:00 PM |
| Shapiro David | Chief Medical Officer | Mar 01, 2019 | Sale | $103.16 | 2,000 | 206,320 | 40,543 | Mar 01, 2019, 07:00 PM |
| Durso Jerome Benedict | Chief Operating Officer | Feb 23, 2019 | Option Exercise | $93.35 | 319 | 29,779 | 34,046 | Feb 26, 2019, 07:00 PM |
| AKKARAJU SRINIVAS | Director | Feb 19, 2019 | Sale | $128.78 | 23,438 | 3,018,346 | 210,937 | Feb 21, 2019, 08:33 PM |
| Shapiro David | Chief Medical Officer | Feb 15, 2019 | Option Exercise | $31.90 | 2,000 | 63,800 | 42,543 | Feb 20, 2019, 09:01 PM |
| Shapiro David | Chief Medical Officer | Feb 15, 2019 | Sale | $111.51 | 2,000 | 223,020 | 40,543 | Feb 20, 2019, 09:01 PM |
| Sullivan Ryan T | General Counsel and Secretary | Feb 13, 2019 | Option Exercise | $110.35 | 1,971 | 217,500 | 27,829 | Feb 14, 2019, 07:01 PM |
| Cawkwell Gail | SVP, Med Affairs, Safety & PV | Feb 12, 2019 | Option Exercise | $111.05 | 1,276 | 141,700 | 17,849 | Feb 14, 2019, 07:00 PM |
| Ford David A | Chief Human Resources Officer | Feb 08, 2019 | Option Exercise | $118.90 | 125 | 14,863 | 12,786 | Feb 11, 2019, 07:00 PM |
| Kim Richard J | President US Comm & Strat Mktg | Jan 13, 2019 | Option Exercise | $109.73 | 77 | 8,449 | 13,737 | Jan 15, 2019, 07:00 PM |
| Bright Lisa | President, International | Jan 07, 2019 | Sale | $104.93 | 1,313 | 137,773 | 18,807 | Jan 09, 2019, 08:00 PM |
| Shapiro David | Chief Medical Officer | Jan 04, 2019 | Sale | $97.48 | 474 | 46,206 | 37,243 | Jan 04, 2019, 07:01 PM |
| Weyer Christian | EVP, Research & Development | Jan 01, 2019 | Option Exercise | $100.79 | 215 | 21,670 | 15,604 | Jan 03, 2019, 07:04 PM |
| Shapiro David | Chief Medical Officer | Jan 01, 2019 | Option Exercise | $100.79 | 736 | 74,181 | 38,416 | Jan 03, 2019, 07:04 PM |
| Shapiro David | Chief Medical Officer | Jan 02, 2019 | Option Exercise | $31.90 | 2,000 | 63,800 | 40,416 | Jan 03, 2019, 07:04 PM |
| Shapiro David | Chief Medical Officer | Jan 03, 2019 | Sale | $97.45 | 699 | 68,118 | 37,717 | Jan 03, 2019, 07:04 PM |
| Shapiro David | Chief Medical Officer | Jan 02, 2019 | Sale | $98.28 | 2,000 | 196,560 | 38,416 | Jan 03, 2019, 07:04 PM |
| Pruzanski Mark | President & CEO | Jan 01, 2019 | Option Exercise | $100.79 | 1,537 | 154,914 | 565,268 | Jan 03, 2019, 07:03 PM |
| Kim Richard J | President US Comm & Strat Mktg | Jan 01, 2019 | Option Exercise | $100.79 | 702 | 70,755 | 13,814 | Jan 03, 2019, 07:03 PM |
| Kapadia Sandip | CFO and Treasurer | Jan 01, 2019 | Option Exercise | $100.79 | 1,118 | 112,683 | 23,423 | Jan 03, 2019, 07:02 PM |
| Ford David A | Chief Human Resources Officer | Jan 01, 2019 | Option Exercise | $100.79 | 423 | 42,634 | 9,111 | Jan 03, 2019, 07:02 PM |
| Durso Jerome Benedict | Chief Operating Officer | Jan 01, 2019 | Option Exercise | $100.79 | 1,219 | 122,863 | 24,965 | Jan 03, 2019, 07:01 PM |
| Bright Lisa | President, International | Jan 01, 2019 | Option Exercise | $100.79 | 1,168 | 117,723 | 20,120 | Jan 03, 2019, 07:00 PM |
| Shapiro David | Chief Medical Officer | Dec 17, 2018 | Option Exercise | $31.90 | 2,000 | 63,800 | 41,152 | Dec 19, 2018, 07:00 PM |
| Shapiro David | Chief Medical Officer | Dec 17, 2018 | Sale | $106.62 | 2,000 | 213,240 | 39,152 | Dec 19, 2018, 07:00 PM |
| Bright Lisa | President, International | Dec 04, 2018 | Sale | $111.00 | 300 | 33,300 | 21,288 | Dec 06, 2018, 07:00 PM |
| Bright Lisa | President, International | Dec 03, 2018 | Sale | $111.45 | 4,700 | 523,820 | 22,488 | Dec 06, 2018, 07:00 PM |
| Micheli Francesco | 10% Owner | Nov 29, 2018 | Sale | $105.07 | 750,000 | 78,802,500 | 6,095,578 | Dec 03, 2018, 04:34 PM |
| Genextra S.p.A. | 10% Owner | Nov 29, 2018 | Sale | $105.07 | 750,000 | 78,802,500 | 6,095,578 | Dec 03, 2018, 04:31 PM |
| Weyer Christian | EVP, Research & Development | Nov 27, 2018 | Option Exercise | $108.66 | 1,438 | 156,253 | 17,162 | Nov 29, 2018, 07:00 PM |
| Weyer Christian | EVP, Research & Development | Nov 29, 2018 | Sale | $113.78 | 1,343 | 152,807 | 15,819 | Nov 29, 2018, 07:00 PM |
| Durso Jerome Benedict | Chief Operating Officer | Nov 23, 2018 | Option Exercise | $111.07 | 460 | 51,092 | 26,184 | Nov 27, 2018, 07:01 PM |
| Bright Lisa | President, International | Nov 24, 2018 | Option Exercise | $111.07 | 247 | 27,434 | 26,288 | Nov 27, 2018, 07:00 PM |
| Pruzanski Mark | President & CEO | Nov 16, 2018 | Option Exercise | $8.67 | 27,606 | 239,253 | 594,411 | Nov 16, 2018, 07:00 PM |
| Pruzanski Mark | President & CEO | Nov 15, 2018 | Option Exercise | $8.67 | 22,394 | 194,082 | 589,199 | Nov 16, 2018, 07:00 PM |
| Pruzanski Mark | President & CEO | Nov 16, 2018 | Sale | $101.54 | 27,606 | 2,803,132 | 584,581 | Nov 16, 2018, 07:00 PM |
| Pruzanski Mark | President & CEO | Nov 15, 2018 | Sale | $100.50 | 22,394 | 2,250,580 | 570,326 | Nov 16, 2018, 07:00 PM |
| Ford David A | Chief Human Resources Officer | Nov 08, 2018 | Option Exercise | $113.79 | 128 | 14,565 | 9,534 | Nov 09, 2018, 07:00 PM |
| Shapiro David | Chief Medical Officer | Nov 01, 2018 | Option Exercise | $21.50 | 2,000 | 43,000 | 41,152 | Nov 02, 2018, 07:01 PM |
| Shapiro David | Chief Medical Officer | Nov 01, 2018 | Sale | $96.32 | 2,000 | 192,640 | 39,152 | Nov 02, 2018, 07:01 PM |
| Kim Richard J | President US Comm & Strat Mktg | Oct 13, 2018 | Option Exercise | $103.73 | 77 | 7,987 | 14,516 | Oct 16, 2018, 07:00 PM |
| Shapiro David | Chief Medical Officer | Oct 15, 2018 | Option Exercise | $21.50 | 3,425 | 73,638 | 42,577 | Oct 16, 2018, 07:00 PM |
| Shapiro David | Chief Medical Officer | Oct 15, 2018 | Sale | $102.95 | 3,425 | 352,604 | 39,152 | Oct 16, 2018, 07:00 PM |
| Shapiro David | Chief Medical Officer | Oct 05, 2018 | Sale | $110.65 | 759 | 83,983 | 39,152 | Oct 05, 2018, 07:01 PM |
| Shapiro David | Chief Medical Officer | Oct 01, 2018 | Option Exercise | $126.46 | 426 | 53,872 | 39,911 | Oct 03, 2018, 07:03 PM |
| Shapiro David | Chief Medical Officer | Jul 01, 2018 | Option Exercise | $83.91 | 416 | 34,907 | 39,911 | Oct 03, 2018, 07:03 PM |
| Shapiro David | Chief Medical Officer | Apr 01, 2018 | Option Exercise | $61.52 | 423 | 26,023 | 39,911 | Oct 03, 2018, 07:03 PM |
| Shapiro David | Chief Medical Officer | Jan 01, 2018 | Option Exercise | $58.42 | 1,020 | 59,588 | 39,911 | Oct 03, 2018, 07:03 PM |
| Kim Richard J | President US Comm & Strat Mktg | Jul 13, 2018 | Option Exercise | $97.10 | 77 | 7,477 | 14,593 | Oct 03, 2018, 07:02 PM |
| Kim Richard J | President US Comm & Strat Mktg | Oct 13, 2017 | Option Exercise | $65.49 | 84 | 5,501 | 14,593 | Oct 03, 2018, 07:02 PM |
| Kim Richard J | President US Comm & Strat Mktg | Jul 01, 2018 | Option Exercise | $83.91 | 144 | 12,083 | 14,593 | Oct 03, 2018, 07:02 PM |
| Kim Richard J | President US Comm & Strat Mktg | Apr 13, 2018 | Option Exercise | $73.07 | 77 | 5,626 | 14,593 | Oct 03, 2018, 07:02 PM |
| Kim Richard J | President US Comm & Strat Mktg | Apr 01, 2018 | Option Exercise | $61.52 | 144 | 8,859 | 14,593 | Oct 03, 2018, 07:02 PM |
| Kim Richard J | President US Comm & Strat Mktg | Feb 10, 2018 | Option Exercise | $54.21 | 1,101 | 59,685 | 14,593 | Oct 03, 2018, 07:02 PM |
| Kim Richard J | President US Comm & Strat Mktg | Jan 13, 2018 | Option Exercise | $54.95 | 89 | 4,891 | 14,593 | Oct 03, 2018, 07:02 PM |
| Kim Richard J | President US Comm & Strat Mktg | Jan 01, 2018 | Option Exercise | $58.42 | 552 | 32,248 | 14,593 | Oct 03, 2018, 07:02 PM |
| Kim Richard J | President US Comm & Strat Mktg | Oct 01, 2018 | Option Exercise | $126.46 | 144 | 18,210 | 14,593 | Oct 03, 2018, 07:02 PM |
| Bright Lisa | President, International | Apr 01, 2018 | Option Exercise | $61.52 | 522 | 32,113 | 26,535 | Oct 03, 2018, 07:02 PM |
| Bright Lisa | President, International | Feb 24, 2018 | Option Exercise | $62.04 | 247 | 15,324 | 26,535 | Oct 03, 2018, 07:02 PM |
| Bright Lisa | President, International | Oct 01, 2018 | Option Exercise | $126.46 | 521 | 65,886 | 26,535 | Oct 03, 2018, 07:02 PM |
| Bright Lisa | President, International | Jan 08, 2018 | Option Exercise | $53.66 | 414 | 22,215 | 26,535 | Oct 03, 2018, 07:02 PM |
| Bright Lisa | President, International | Aug 24, 2018 | Option Exercise | $108.45 | 247 | 26,787 | 26,535 | Oct 03, 2018, 07:02 PM |
| Bright Lisa | President, International | Jan 01, 2018 | Option Exercise | $58.42 | 935 | 54,623 | 26,535 | Oct 03, 2018, 07:02 PM |
| Bright Lisa | President, International | Jul 01, 2018 | Option Exercise | $83.91 | 521 | 43,717 | 26,535 | Oct 03, 2018, 07:02 PM |
| Bright Lisa | President, International | Dec 18, 2017 | Option Exercise | $62.08 | 414 | 25,701 | 26,535 | Oct 03, 2018, 07:02 PM |
| Bright Lisa | President, International | May 31, 2018 | Option Exercise | $70.21 | 414 | 29,067 | 26,535 | Oct 03, 2018, 07:02 PM |
| Bright Lisa | President, International | Nov 24, 2017 | Option Exercise | $63.20 | 247 | 15,610 | 26,535 | Oct 03, 2018, 07:02 PM |
| Bright Lisa | President, International | May 24, 2018 | Option Exercise | $69.76 | 247 | 17,231 | 26,535 | Oct 03, 2018, 07:02 PM |
| Kapadia Sandip | CFO and Treasurer | Jan 01, 2018 | Option Exercise | $58.42 | 1,107 | 64,671 | 24,541 | Oct 03, 2018, 07:01 PM |
| Kapadia Sandip | CFO and Treasurer | Oct 01, 2018 | Option Exercise | $126.46 | 531 | 67,150 | 24,541 | Oct 03, 2018, 07:01 PM |
| Kapadia Sandip | CFO and Treasurer | Jul 01, 2018 | Option Exercise | $83.91 | 468 | 39,270 | 24,541 | Oct 03, 2018, 07:01 PM |
| Kapadia Sandip | CFO and Treasurer | Apr 01, 2018 | Option Exercise | $61.52 | 468 | 28,791 | 24,541 | Oct 03, 2018, 07:01 PM |
| Durso Jerome Benedict | Chief Operating Officer | Aug 23, 2018 | Option Exercise | $107.63 | 319 | 34,334 | 26,644 | Oct 03, 2018, 07:01 PM |
| Durso Jerome Benedict | Chief Operating Officer | May 23, 2018 | Option Exercise | $69.96 | 319 | 22,317 | 26,644 | Oct 03, 2018, 07:01 PM |
| Durso Jerome Benedict | Chief Operating Officer | Feb 23, 2018 | Option Exercise | $62.04 | 1,318 | 81,769 | 26,644 | Oct 03, 2018, 07:01 PM |
| Ford David A | Chief Human Resources Officer | May 08, 2018 | Option Exercise | $70.15 | 510 | 35,777 | 9,662 | Oct 03, 2018, 07:00 PM |
| Ford David A | Chief Human Resources Officer | Aug 08, 2018 | Option Exercise | $116.84 | 128 | 14,956 | 9,662 | Oct 03, 2018, 07:00 PM |
| Pruzanski Mark | President & CEO | Oct 01, 2018 | Option Exercise | $126.46 | 2,049 | 259,117 | 566,805 | Oct 03, 2018, 07:00 PM |
| Pruzanski Mark | President & CEO | Jul 01, 2018 | Option Exercise | $83.91 | 2,051 | 172,099 | 566,805 | Oct 03, 2018, 07:00 PM |
| Pruzanski Mark | President & CEO | Apr 01, 2018 | Option Exercise | $61.52 | 2,050 | 126,116 | 566,805 | Oct 03, 2018, 07:00 PM |
| Pruzanski Mark | President & CEO | Jan 01, 2018 | Option Exercise | $58.42 | 3,609 | 210,838 | 566,805 | Oct 03, 2018, 07:00 PM |
| Shapiro David | Chief Medical Officer | Sep 05, 2018 | Sale | $111.43 | 4,917 | 547,891 | 42,196 | Sep 07, 2018, 06:00 PM |
| Gottesdiener Keith Michael | Director | Apr 09, 2018 | Buy | $64.00 | 1,171 | 74,944 | 5,001 | Apr 09, 2018, 07:37 PM |
| Pruzanski Mark | CEO & President | Apr 09, 2018 | Buy | $64.00 | 7,812 | 499,968 | 576,564 | Apr 09, 2018, 07:36 PM |
| BRADBURY DANIEL | Director | Apr 09, 2018 | Buy | $64.00 | 7,812 | 499,968 | 11,642 | Apr 09, 2018, 07:36 PM |
| Genextra S.p.A. | 10% Owner | Apr 09, 2018 | Buy | $64.00 | 390,625 | 25,000,000 | 6,845,578 | Apr 09, 2018, 05:20 PM |
| Micheli Francesco | 10% Owner | Apr 09, 2018 | Buy | $64.00 | 390,625 | 25,000,000 | 6,845,578 | Apr 09, 2018, 05:19 PM |
| AKKARAJU SRINIVAS | Director | Apr 05, 2018 | Option Exercise | $64.00 | 234,375 | 15,000,000 | 234,375 | Apr 09, 2018, 05:10 PM |
| Kim Richard J | SVP, Commercial US | Oct 02, 2017 | Sale | $58.10 | 48 | 2,789 | 11,205 | Oct 04, 2017, 09:02 PM |
| Kapadia Sandip | Chief Financial Officer | Oct 02, 2017 | Sale | $58.83 | 354 | 20,827 | 20,215 | Oct 04, 2017, 09:02 PM |
| Bright Lisa | President International | Oct 02, 2017 | Sale | $58.92 | 390 | 22,980 | 22,834 | Oct 04, 2017, 09:01 PM |
| Shapiro David | CMO and EVP - Development | Oct 02, 2017 | Sale | $58.90 | 349 | 20,556 | 44,213 | Oct 04, 2017, 09:01 PM |
| Pruzanski Mark | CEO & President | Oct 02, 2017 | Sale | $58.87 | 1,532 | 90,189 | 568,752 | Oct 04, 2017, 09:01 PM |
| McMinn Rachel | Chief Strategy Officer | Oct 02, 2017 | Sale | $58.89 | 283 | 16,667 | 16,875 | Oct 04, 2017, 09:00 PM |
| Shapiro David | CMO and EVP - Development | Sep 01, 2017 | Option Exercise | $31.90 | 1,250 | 39,875 | 45,812 | Sep 05, 2017, 09:00 PM |
| Shapiro David | CMO and EVP - Development | Sep 01, 2017 | Sale | $117.43 | 1,250 | 146,788 | 44,562 | Sep 05, 2017, 09:00 PM |
| Bright Lisa | President International | Aug 25, 2017 | Sale | $111.31 | 253 | 28,161 | 23,324 | Aug 29, 2017, 09:00 PM |
| Bright Lisa | President International | Aug 02, 2017 | Sale | $110.29 | 142 | 15,661 | 23,477 | Aug 02, 2017, 09:01 PM |
| Shapiro David | CMO and EVP - Development | Aug 01, 2017 | Option Exercise | $8.67 | 1,118 | 9,689 | 45,680 | Aug 02, 2017, 09:00 PM |
| Shapiro David | CMO and EVP - Development | Aug 01, 2017 | Sale | $119.00 | 1,118 | 133,042 | 44,562 | Aug 02, 2017, 09:00 PM |
| WELCH DANIEL G | Director | Jul 31, 2017 | Sale | $123.93 | 602 | 74,603 | 3,108 | Aug 02, 2017, 09:00 PM |
| McMinn Rachel | Chief Strategy Officer | Jul 31, 2017 | Sale | $123.12 | 130 | 16,005 | 17,158 | Aug 02, 2017, 08:59 PM |
| WELCH DANIEL G | Director | Jul 20, 2017 | Sale | $126.76 | 217 | 27,507 | 3,710 | Jul 21, 2017, 09:00 PM |
| Kim Richard J | SVP, Commercial US | Jul 14, 2017 | Sale | $128.64 | 89 | 11,449 | 11,253 | Jul 18, 2017, 09:00 PM |
| Shapiro David | CMO and EVP - Development | Jul 11, 2017 | Sale | $124.01 | 553 | 68,578 | 44,562 | Jul 13, 2017, 09:00 PM |
| Kapadia Sandip | Chief Financial Officer | Jul 03, 2017 | Sale | $121.59 | 1,431 | 174,000 | 20,569 | Jul 05, 2017, 09:02 PM |
| Shapiro David | CMO and EVP - Development | Jul 03, 2017 | Sale | $121.24 | 350 | 42,435 | 45,215 | Jul 05, 2017, 09:01 PM |
| Pruzanski Mark | CEO & President | Jul 03, 2017 | Sale | $121.78 | 1,434 | 174,633 | 570,284 | Jul 05, 2017, 09:01 PM |
| McMinn Rachel | Chief Strategy Officer | Jul 03, 2017 | Sale | $121.78 | 257 | 31,297 | 17,288 | Jul 05, 2017, 09:00 PM |
| Bright Lisa | President International | Jul 03, 2017 | Sale | $121.32 | 394 | 47,802 | 23,619 | Jul 05, 2017, 09:00 PM |
| Kim Richard J | SVP, Commercial US | Jul 03, 2017 | Sale | $121.69 | 50 | 6,085 | 11,342 | Jul 05, 2017, 08:59 PM |
| Pruzanski Mark | CEO & President | Jun 26, 2017 | Option Exercise | $8.67 | 40,000 | 346,668 | 611,718 | Jun 28, 2017, 09:00 PM |
| Pruzanski Mark | CEO & President | Jun 26, 2017 | Sale | $130.80 | 40,000 | 5,231,856 | 603,902 | Jun 28, 2017, 09:00 PM |
| Bright Lisa | President International | Jun 01, 2017 | Sale | $110.73 | 698 | 77,289 | 24,613 | Jun 02, 2017, 09:00 PM |
| Bright Lisa | President International | May 25, 2017 | Sale | $117.52 | 254 | 29,850 | 23,246 | May 30, 2017, 09:00 PM |
| Bright Lisa | President International | May 16, 2017 | Sale | $119.74 | 113 | 13,531 | 23,600 | May 18, 2017, 09:00 PM |
| Bright Lisa | President International | May 02, 2017 | Sale | $114.00 | 426 | 48,564 | 23,378 | May 10, 2017, 09:05 PM |
| Shapiro David | CMO and EVP - Development | May 01, 2017 | Option Exercise | $8.67 | 1,117 | 9,681 | 46,582 | May 03, 2017, 09:01 PM |
| Shapiro David | CMO and EVP - Development | May 01, 2017 | Sale | $112.18 | 1,117 | 125,305 | 45,465 | May 03, 2017, 09:01 PM |
| McMinn Rachel | Chief Strategy Officer | May 01, 2017 | Sale | $113.12 | 114 | 12,896 | 17,545 | May 03, 2017, 09:01 PM |
| Shapiro David | CMO and EVP - Development | Apr 10, 2017 | Sale | $108.51 | 558 | 60,549 | 45,465 | Apr 11, 2017, 09:00 PM |
| McMinn Rachel | Chief Strategy Officer | Apr 03, 2017 | Sale | $115.00 | 257 | 29,554 | 17,659 | Apr 05, 2017, 09:01 PM |
| Bright Lisa | President International | Apr 03, 2017 | Sale | $115.00 | 389 | 44,734 | 22,925 | Apr 05, 2017, 09:01 PM |
| Shapiro David | CMO and EVP - Development | Apr 03, 2017 | Sale | $115.00 | 346 | 39,789 | 46,023 | Apr 05, 2017, 09:00 PM |
| Pruzanski Mark | CEO & President | Apr 03, 2017 | Sale | $115.00 | 1 | 115 | 571,718 | Apr 05, 2017, 09:00 PM |
| Bright Lisa | President International | Mar 02, 2017 | Sale | $130.16 | 1,313 | 170,904 | 23,314 | Mar 06, 2017, 09:01 PM |
| Shapiro David | CMO and EVP - Development | Mar 01, 2017 | Option Exercise | $21.50 | 1,350 | 29,025 | 47,719 | Mar 03, 2017, 09:01 PM |
| Shapiro David | CMO and EVP - Development | Mar 01, 2017 | Sale | $128.66 | 1,350 | 173,691 | 46,369 | Mar 03, 2017, 09:01 PM |
| Bright Lisa | President International | Mar 01, 2017 | Sale | $130.16 | 136 | 17,702 | 21,813 | Mar 03, 2017, 09:00 PM |
| Bright Lisa | President International | Feb 27, 2017 | Sale | $119.48 | 254 | 30,348 | 21,695 | Mar 01, 2017, 09:00 PM |
| Bright Lisa | President International | Jan 31, 2017 | Sale | $108.96 | 134 | 14,601 | 17,249 | Feb 02, 2017, 09:00 PM |
| Shapiro David | CMO and EVP - Development | Jan 09, 2017 | Sale | $106.01 | 1,565 | 165,906 | 40,369 | Jan 11, 2017, 09:00 PM |
| Bright Lisa | President International | Jan 03, 2017 | Sale | $103.92 | 1,119 | 116,285 | 17,090 | Jan 05, 2017, 09:01 PM |
| Shapiro David | CMO and EVP - Development | Jan 03, 2017 | Sale | $103.92 | 988 | 102,672 | 41,934 | Jan 05, 2017, 09:01 PM |
| Pruzanski Mark | CEO & President | Jan 03, 2017 | Sale | $103.92 | 2,802 | 291,181 | 552,705 | Jan 05, 2017, 09:00 PM |
| McMinn Rachel | Chief Strategy Officer | Jan 03, 2017 | Sale | $103.92 | 816 | 84,798 | 12,916 | Jan 05, 2017, 09:00 PM |
| Pruzanski Mark | CEO & President | Dec 06, 2016 | Option Exercise | $28.67 | 3,487 | 99,982 | 555,507 | Dec 08, 2016, 09:00 PM |
| Shapiro David | CMO and EVP - Development | Dec 02, 2016 | Sale | $99.75 | 1,350 | 134,663 | 42,922 | Dec 06, 2016, 09:00 PM |
| Bright Lisa | President International | Nov 25, 2016 | Sale | $113.60 | 249 | 28,286 | 18,209 | Nov 29, 2016, 09:00 PM |
| Bright Lisa | President International | Nov 15, 2016 | Sale | $112.27 | 140 | 15,718 | 18,458 | Nov 17, 2016, 09:39 PM |
| McMinn Rachel | Chief Strategy Officer | Oct 31, 2016 | Sale | $123.82 | 129 | 15,972 | 13,732 | Nov 02, 2016, 09:00 PM |
| Shapiro David | CMO and EVP - Development | Oct 10, 2016 | Sale | $153.34 | 411 | 63,023 | 44,272 | Oct 12, 2016, 09:00 PM |
| Pruzanski Mark | CEO & President | Oct 03, 2016 | Sale | $163.20 | 705 | 115,056 | 552,020 | Oct 05, 2016, 09:07 PM |
| Shapiro David | CMO and EVP - Development | Oct 03, 2016 | Option Exercise | $21.50 | 1,350 | 29,025 | 46,196 | Oct 05, 2016, 09:06 PM |
| Shapiro David | CMO and EVP - Development | Oct 03, 2016 | Sale | $163.08 | 1,513 | 246,733 | 44,846 | Oct 05, 2016, 09:06 PM |
| Duncan Barbara Gayle | Chief Accounting Officer | Oct 03, 2016 | Sale | $163.20 | 147 | 23,990 | 30,661 | Oct 05, 2016, 09:04 PM |
| Bright Lisa | See Remarks | Oct 03, 2016 | Sale | $163.20 | 155 | 25,296 | 18,305 | Oct 05, 2016, 09:02 PM |
| Shapiro David | CMO and EVP - Development | Sep 26, 2016 | Sale | $165.08 | 3,545 | 585,199 | 45,732 | Sep 28, 2016, 09:00 PM |
| Pruzanski Mark | CEO & President | Sep 20, 2016 | Option Exercise | $8.94 | 35,000 | 313,054 | 587,725 | Sep 22, 2016, 09:00 PM |
| Pruzanski Mark | CEO & President | Sep 20, 2016 | Sale | $165.00 | 35,000 | 5,775,000 | 552,725 | Sep 22, 2016, 09:00 PM |
| Bright Lisa | President of International | Aug 25, 2016 | Sale | $159.00 | 246 | 39,114 | 18,460 | Aug 25, 2016, 09:00 PM |
| McMinn Rachel | Chief Strategy Officer | Aug 01, 2016 | Sale | $176.57 | 125 | 22,071 | 13,861 | Aug 02, 2016, 09:00 PM |
| Pruzanski Mark | CEO & President | Jul 15, 2016 | Option Exercise | $148.73 | 7,341 | 1,091,827 | 552,725 | Jul 19, 2016, 09:00 PM |
| Pruzanski Mark | CEO & President | Jul 15, 2016 | Option Exercise | $9.82 | 12,500 | 122,779 | 560,066 | Jul 19, 2016, 09:00 PM |
| Duncan Barbara Gayle | Chief Accounting Officer | Jul 05, 2016 | Sale | $145.11 | 146 | 21,186 | 30,808 | Jul 07, 2016, 09:03 PM |
| Shapiro David | CMO and EVP - Development | Jul 05, 2016 | Sale | $145.11 | 163 | 23,653 | 48,391 | Jul 07, 2016, 09:02 PM |
| Pruzanski Mark | CEO & President | Jul 05, 2016 | Sale | $145.11 | 714 | 103,608 | 547,566 | Jul 07, 2016, 09:02 PM |
| McMinn Rachel | Chief Strategy Officer | Jul 05, 2016 | Sale | $145.11 | 106 | 15,382 | 13,986 | Jul 07, 2016, 09:01 PM |
| Bright Lisa | See Remarks | Jul 05, 2016 | Sale | $145.11 | 155 | 22,492 | 18,706 | Jul 07, 2016, 09:00 PM |
| Bright Lisa | See Remarks | May 25, 2016 | Sale | $137.50 | 251 | 34,512 | 18,855 | May 26, 2016, 09:00 PM |
| AKKARAJU SRINIVAS | Director | May 13, 2016 | Option Exercise | $21.50 | 1,500 | 32,250 | 12,042 | May 17, 2016, 09:00 PM |
| McMinn Rachel | Chief Strategy Officer | May 02, 2016 | Sale | $147.49 | 130 | 19,174 | 14,087 | May 04, 2016, 09:00 PM |
| Shapiro David | CMO and EVP - Development | Apr 04, 2016 | Sale | $130.76 | 165 | 21,575 | 48,546 | Apr 06, 2016, 09:02 PM |
| Pruzanski Mark | CEO & President | Apr 04, 2016 | Sale | $130.76 | 708 | 92,578 | 548,248 | Apr 06, 2016, 09:02 PM |
| McMinn Rachel | Chief Strategy Officer | Apr 04, 2016 | Sale | $130.76 | 104 | 13,599 | 14,217 | Apr 06, 2016, 09:01 PM |
| Bright Lisa | See Remarks | Apr 04, 2016 | Sale | $130.76 | 153 | 20,006 | 19,106 | Apr 06, 2016, 09:01 PM |
| Duncan Barbara Gayle | Chief Financial Officer | Apr 04, 2016 | Sale | $130.76 | 144 | 18,829 | 30,948 | Apr 06, 2016, 09:00 PM |
| Bright Lisa | See Remarks | Feb 25, 2016 | Sale | $115.22 | 241 | 27,768 | 19,259 | Feb 29, 2016, 09:00 PM |
| McMinn Rachel | Chief Strategy Officer | Feb 01, 2016 | Sale | $103.56 | 128 | 13,256 | 7,621 | Feb 03, 2016, 09:00 PM |
| Bright Lisa | See Remarks | Jan 13, 2016 | Sale | $129.99 | 104 | 13,519 | 11,700 | Jan 14, 2016, 09:00 PM |
| Bright Lisa | See Remarks | Jan 12, 2016 | Sale | $124.78 | 624 | 77,862 | 11,804 | Jan 14, 2016, 09:00 PM |
| McMinn Rachel | Chief Strategy Officer | Jan 04, 2016 | Sale | $145.90 | 469 | 68,429 | 7,749 | Jan 05, 2016, 09:01 PM |
| Duncan Barbara Gayle | Chief Financial Officer | Jan 04, 2016 | Sale | $145.90 | 468 | 68,283 | 25,320 | Jan 05, 2016, 09:00 PM |
| Shapiro David | CMO and EVP - Development | Jan 04, 2016 | Sale | $145.90 | 533 | 77,767 | 41,407 | Jan 05, 2016, 09:00 PM |
| Pruzanski Mark | CEO & President | Jan 04, 2016 | Sale | $145.90 | 2,126 | 310,192 | 529,681 | Jan 05, 2016, 09:00 PM |
| Shapiro David | CMO and EVP - Development | Dec 18, 2015 | Option Exercise | $17.50 | 11,426 | 199,991 | 39,821 | Dec 22, 2015, 10:00 AM |
| Shapiro David | CMO and EVP - Development | Dec 15, 2015 | Option Exercise | $8.67 | 3,500 | 30,333 | 31,895 | Dec 17, 2015, 09:00 PM |
| Shapiro David | CMO and EVP - Development | Dec 15, 2015 | Sale | $157.40 | 3,500 | 550,900 | 29,395 | Dec 17, 2015, 09:00 PM |
| Bright Lisa | See Remarks | Nov 25, 2015 | Sale | $182.96 | 1,150 | 210,410 | 12,428 | Nov 30, 2015, 09:00 PM |
| WILLIAMS NICOLE | Director | Nov 20, 2015 | Option Exercise | $9.82 | 973 | 9,557 | 1,935 | Nov 23, 2015, 09:01 PM |
| WILLIAMS NICOLE | Director | Nov 20, 2015 | Sale | $167.00 | 973 | 162,491 | 962 | Nov 23, 2015, 09:01 PM |
| Shapiro David | CMO and EVP - Development | Nov 16, 2015 | Option Exercise | $8.67 | 3,500 | 30,333 | 32,659 | Nov 18, 2015, 09:00 PM |
| Shapiro David | CMO and EVP - Development | Nov 16, 2015 | Sale | $178.53 | 4,264 | 761,238 | 29,895 | Nov 18, 2015, 09:00 PM |
| VEITINGER KLAUS R DR | Director | Nov 10, 2015 | Option Exercise | $21.50 | 1,000 | 21,500 | 3,166 | Nov 12, 2015, 09:01 PM |
| VEITINGER KLAUS R DR | Director | Nov 10, 2015 | Sale | $198.25 | 1,000 | 198,250 | 2,166 | Nov 12, 2015, 09:01 PM |
| Shapiro David | CMO and EVP - Development | Nov 10, 2015 | Option Exercise | $8.67 | 3,500 | 30,333 | 32,659 | Nov 12, 2015, 09:00 PM |
| Shapiro David | CMO and EVP - Development | Nov 10, 2015 | Sale | $204.15 | 3,500 | 714,525 | 29,159 | Nov 12, 2015, 09:00 PM |
| McMinn Rachel | Chief Strategy Officer | Nov 02, 2015 | Sale | $160.24 | 125 | 20,029 | 8,218 | Nov 04, 2015, 09:00 PM |
| AKKARAJU SRINIVAS | Director | Oct 28, 2015 | Option Exercise | $21.50 | 1,250 | 26,875 | 9,892 | Oct 30, 2015, 11:59 AM |
| WILLIAMS NICOLE | Director | Oct 20, 2015 | Option Exercise | $9.82 | 974 | 9,567 | 1,936 | Oct 22, 2015, 09:00 PM |
| WILLIAMS NICOLE | Director | Oct 20, 2015 | Sale | $182.22 | 974 | 177,482 | 962 | Oct 22, 2015, 09:00 PM |
| Duncan Barbara Gayle | Chief Financial Officer | Oct 01, 2015 | Option Exercise | $8.67 | 1,000 | 8,667 | 23,818 | Oct 05, 2015, 09:02 PM |
| Duncan Barbara Gayle | Chief Financial Officer | Oct 02, 2015 | Sale | $159.04 | 54 | 8,588 | 24,062 | Oct 05, 2015, 09:02 PM |
| Duncan Barbara Gayle | Chief Financial Officer | Oct 01, 2015 | Sale | $163.39 | 1,000 | 163,390 | 24,116 | Oct 05, 2015, 09:02 PM |
| Shapiro David | CMO and EVP - Development | Oct 02, 2015 | Sale | $159.04 | 858 | 136,455 | 29,159 | Oct 05, 2015, 09:02 PM |
| Shapiro David | CMO and EVP - Development | Oct 01, 2015 | Sale | $163.39 | 282 | 46,076 | 30,017 | Oct 05, 2015, 09:02 PM |
| Pruzanski Mark | CEO & President | Oct 02, 2015 | Sale | $159.04 | 167 | 26,560 | 526,814 | Oct 05, 2015, 09:01 PM |
| WILLIAMS NICOLE | Director | Sep 21, 2015 | Option Exercise | $9.82 | 973 | 9,557 | 1,935 | Sep 23, 2015, 09:00 PM |
| WILLIAMS NICOLE | Director | Sep 21, 2015 | Sale | $194.82 | 973 | 189,560 | 962 | Sep 23, 2015, 09:00 PM |
| Shapiro David | CMO and EVP - Development | Sep 15, 2015 | Option Exercise | $8.67 | 8,794 | 76,215 | 27,027 | Sep 17, 2015, 09:00 PM |
| Shapiro David | CMO and EVP - Development | Sep 15, 2015 | Sale | $191.28 | 3,500 | 669,480 | 26,027 | Sep 17, 2015, 09:00 PM |
| VEITINGER KLAUS R DR | Director | Sep 09, 2015 | Option Exercise | $21.50 | 500 | 10,750 | 2,666 | Sep 11, 2015, 09:00 PM |
| VEITINGER KLAUS R DR | Director | Sep 09, 2015 | Sale | $198.25 | 500 | 99,125 | 2,166 | Sep 11, 2015, 09:00 PM |
| WILLIAMS NICOLE | Director | Aug 20, 2015 | Option Exercise | $9.82 | 974 | 9,567 | 1,936 | Aug 24, 2015, 09:00 PM |
| WILLIAMS NICOLE | Director | Aug 20, 2015 | Sale | $206.85 | 974 | 201,472 | 962 | Aug 24, 2015, 09:00 PM |
| Shapiro David | CMO and EVP - Development | Aug 17, 2015 | Option Exercise | $8.67 | 3,500 | 30,333 | 22,505 | Aug 19, 2015, 09:00 PM |
| Shapiro David | CMO and EVP - Development | Aug 17, 2015 | Sale | $209.37 | 4,272 | 894,429 | 18,233 | Aug 19, 2015, 09:00 PM |
| VEITINGER KLAUS R DR | Director | Aug 03, 2015 | Option Exercise | $21.50 | 500 | 10,750 | 2,666 | Aug 05, 2015, 09:00 PM |
| VEITINGER KLAUS R DR | Director | Aug 03, 2015 | Sale | $261.17 | 500 | 130,585 | 2,166 | Aug 05, 2015, 09:00 PM |
| McMinn Rachel | Chief Strategy Officer | Jul 31, 2015 | Sale | $262.09 | 127 | 33,286 | 4,293 | Aug 04, 2015, 09:02 PM |
| Fundaro Paolo | Director | Jul 24, 2015 | Sale | $285.00 | 582 | 165,870 | 8,221 | Jul 24, 2015, 09:12 PM |
| WILLIAMS NICOLE | Director | Jul 20, 2015 | Option Exercise | $9.82 | 973 | 9,557 | 1,935 | Jul 22, 2015, 09:00 PM |
| WILLIAMS NICOLE | Director | Jul 20, 2015 | Sale | $279.01 | 973 | 271,477 | 962 | Jul 22, 2015, 09:00 PM |
| McMinn Rachel | Chief Strategy Officer | May 01, 2015 | Sale | $255.12 | 503 | 128,327 | 4,420 | Jul 17, 2015, 09:00 PM |
| Pruzanski Mark | CEO & President | Jul 10, 2015 | Option Exercise | $8.67 | 12,500 | 108,334 | 519,514 | Jul 14, 2015, 09:00 PM |
| Pruzanski Mark | CEO & President | Jul 10, 2015 | Sale | $250.00 | 12,500 | 3,125,000 | 507,014 | Jul 14, 2015, 09:00 PM |
| Adorini Luciano | Chief Scientific Officer | Jul 06, 2015 | Option Exercise | $21.29 | 4,067 | 86,581 | 14,776 | Jul 08, 2015, 09:00 PM |
| Adorini Luciano | Chief Scientific Officer | Jul 06, 2015 | Sale | $579.93 | 4,067 | 2,358,589 | 14,176 | Jul 08, 2015, 09:00 PM |
| Shapiro David | CMO and EVP - Development | Jul 02, 2015 | Sale | $236.29 | 851 | 201,083 | 19,055 | Jul 07, 2015, 09:00 PM |
| Pruzanski Mark | CEO & President | Jul 02, 2015 | Sale | $236.26 | 158 | 37,328 | 507,023 | Jul 07, 2015, 09:00 PM |
| Duncan Barbara Gayle | Chief Financial Officer | Jul 02, 2015 | Sale | $236.26 | 53 | 12,522 | 18,771 | Jul 07, 2015, 09:00 PM |
| Duncan Barbara Gayle | Chief Financial Officer | Jul 01, 2015 | Option Exercise | $8.67 | 1,000 | 8,667 | 18,523 | Jul 06, 2015, 09:00 PM |
| Duncan Barbara Gayle | Chief Financial Officer | Jul 01, 2015 | Sale | $242.10 | 1,000 | 242,100 | 17,523 | Jul 06, 2015, 09:00 PM |
| Shapiro David | CMO and EVP - Development | Jul 01, 2015 | Option Exercise | $8.67 | 3,500 | 30,333 | 22,014 | Jul 06, 2015, 09:00 PM |
| Shapiro David | CMO and EVP - Development | Jul 01, 2015 | Sale | $238.66 | 3,781 | 902,379 | 21,014 | Jul 06, 2015, 09:00 PM |
| WILLIAMS NICOLE | Director | Jun 22, 2015 | Option Exercise | $9.82 | 974 | 9,567 | 1,936 | Jun 24, 2015, 09:00 PM |
| WILLIAMS NICOLE | Director | Jun 22, 2015 | Sale | $265.14 | 974 | 258,246 | 962 | Jun 24, 2015, 09:00 PM |
| Shapiro David | CMO and EVP - Development | Jun 15, 2015 | Option Exercise | $8.67 | 3,500 | 30,333 | 22,014 | Jun 17, 2015, 09:00 PM |
| Shapiro David | CMO and EVP - Development | Jun 15, 2015 | Sale | $241.58 | 3,500 | 845,546 | 20,414 | Jun 17, 2015, 09:00 PM |
| VEITINGER KLAUS R DR | Director | Jun 10, 2015 | Option Exercise | $21.50 | 391 | 8,407 | 2,557 | Jun 12, 2015, 09:00 PM |
| VEITINGER KLAUS R DR | Director | Jun 10, 2015 | Sale | $238.21 | 391 | 93,140 | 2,166 | Jun 12, 2015, 09:00 PM |
| Adorini Luciano | Chief Scientific Officer | Jun 08, 2015 | Option Exercise | $8.67 | 4,000 | 34,667 | 14,060 | Jun 10, 2015, 09:00 PM |
| Adorini Luciano | Chief Scientific Officer | Jun 08, 2015 | Sale | $248.40 | 4,000 | 993,598 | 12,060 | Jun 10, 2015, 09:00 PM |
| Pruzanski Mark | CEO & President | Jun 03, 2015 | Option Exercise | $17.76 | 6,561 | 116,550 | 502,304 | Jun 05, 2015, 09:00 PM |
| WILLIAMS NICOLE | Director | May 20, 2015 | Option Exercise | $9.82 | 973 | 9,557 | 1,935 | May 22, 2015, 09:00 PM |
| WILLIAMS NICOLE | Director | May 20, 2015 | Sale | $260.20 | 973 | 253,175 | 962 | May 22, 2015, 09:00 PM |
| AKKARAJU SRINIVAS | Director | May 19, 2015 | Option Exercise | $21.50 | 1,000 | 21,500 | 8,642 | May 22, 2015, 09:00 PM |
| Shapiro David | CMO and EVP - Development | May 15, 2015 | Option Exercise | $8.67 | 3,500 | 30,333 | 22,793 | May 19, 2015, 09:01 PM |
| Shapiro David | CMO and EVP - Development | May 15, 2015 | Sale | $306.90 | 4,279 | 1,313,244 | 20,498 | May 19, 2015, 09:01 PM |
| Pruzanski Mark | CEO & President | May 14, 2015 | Option Exercise | $8.67 | 5,000 | 43,334 | 500,743 | May 18, 2015, 09:00 PM |
| Pruzanski Mark | CEO & President | May 14, 2015 | Sale | $300.00 | 5,000 | 1,500,000 | 495,743 | May 18, 2015, 09:00 PM |
| VEITINGER KLAUS R DR | Director | May 11, 2015 | Option Exercise | $21.50 | 391 | 8,407 | 2,557 | May 13, 2015, 09:00 PM |
| VEITINGER KLAUS R DR | Director | May 11, 2015 | Sale | $279.07 | 391 | 109,117 | 2,399 | May 13, 2015, 09:00 PM |
| Adorini Luciano | Chief Scientific Officer | May 06, 2015 | Option Exercise | $8.67 | 4,000 | 34,667 | 14,060 | May 08, 2015, 09:00 PM |
| Adorini Luciano | Chief Scientific Officer | May 06, 2015 | Sale | $259.97 | 4,000 | 1,039,863 | 12,260 | May 08, 2015, 09:00 PM |
| Pruzanski Mark | CEO & President | May 01, 2015 | Option Exercise | $8.67 | 12,500 | 108,334 | 508,243 | May 05, 2015, 09:00 PM |
| Pruzanski Mark | CEO & President | May 01, 2015 | Sale | $253.56 | 12,500 | 3,169,495 | 506,543 | May 05, 2015, 09:00 PM |
| WILLIAMS NICOLE | Director | Apr 20, 2015 | Option Exercise | $9.82 | 974 | 9,567 | 1,936 | Apr 22, 2015, 09:00 PM |
| WILLIAMS NICOLE | Director | Apr 20, 2015 | Sale | $278.50 | 974 | 271,259 | 962 | Apr 22, 2015, 09:00 PM |
| VEITINGER KLAUS R DR | Director | Apr 10, 2015 | Option Exercise | $21.50 | 391 | 8,407 | 2,557 | Apr 14, 2015, 09:00 PM |
| VEITINGER KLAUS R DR | Director | Apr 10, 2015 | Sale | $272.10 | 391 | 106,391 | 2,166 | Apr 14, 2015, 09:00 PM |
| Adorini Luciano | Chief Scientific Officer | Apr 06, 2015 | Option Exercise | $8.67 | 4,000 | 34,667 | 14,060 | Apr 08, 2015, 09:00 PM |
| Adorini Luciano | Chief Scientific Officer | Apr 06, 2015 | Sale | $269.64 | 4,000 | 1,078,570 | 13,060 | Apr 08, 2015, 09:00 PM |
| Shapiro David | CMO and EVP - Development | Apr 01, 2015 | Option Exercise | $8.82 | 2,334 | 20,580 | 22,752 | Apr 03, 2015, 09:01 PM |
| Shapiro David | CMO and EVP - Development | Apr 02, 2015 | Sale | $277.70 | 843 | 234,102 | 19,293 | Apr 03, 2015, 09:01 PM |
| Shapiro David | CMO and EVP - Development | Apr 01, 2015 | Sale | $274.47 | 2,616 | 718,001 | 21,418 | Apr 03, 2015, 09:01 PM |
| Duncan Barbara Gayle | Chief Financial Officer | Apr 02, 2015 | Sale | $277.70 | 39 | 10,830 | 17,523 | Apr 03, 2015, 09:01 PM |
| Pruzanski Mark | CEO & President | Apr 02, 2015 | Sale | $277.70 | 157 | 43,599 | 495,743 | Apr 03, 2015, 09:00 PM |
| Duncan Barbara Gayle | Chief Financial Officer | Mar 27, 2015 | Sale | $289.82 | 1,000 | 289,817 | 17,164 | Apr 01, 2015, 10:00 AM |
| SILVERSTEIN JONATHAN | Director | Mar 26, 2015 | Sale | $286.75 | 157,200 | 45,076,442 | 1,271,901 | Mar 30, 2015, 03:59 PM |
| ORBIMED ADVISORS LLC | Director | Mar 26, 2015 | Sale | $286.75 | 157,200 | 45,076,442 | 1,271,901 | Mar 30, 2015, 03:58 PM |
| SILVERSTEIN JONATHAN | Director | Mar 25, 2015 | Sale | $270.23 | 2,800 | 756,644 | 1,277,524 | Mar 25, 2015, 07:34 PM |
| SILVERSTEIN JONATHAN | Director | Mar 24, 2015 | Sale | $272.00 | 45,600 | 12,402,995 | 1,319,160 | Mar 25, 2015, 07:34 PM |
| SILVERSTEIN JONATHAN | Director | Mar 23, 2015 | Sale | $275.18 | 159,400 | 43,863,068 | 1,444,726 | Mar 25, 2015, 07:34 PM |
| ORBIMED ADVISORS LLC | Director | Mar 25, 2015 | Sale | $270.23 | 2,800 | 756,644 | 1,277,524 | Mar 25, 2015, 07:28 PM |
| ORBIMED ADVISORS LLC | Director | Mar 24, 2015 | Sale | $272.00 | 45,600 | 12,402,995 | 1,319,160 | Mar 25, 2015, 07:28 PM |
| ORBIMED ADVISORS LLC | Director | Mar 23, 2015 | Sale | $275.18 | 159,400 | 43,863,068 | 1,444,726 | Mar 25, 2015, 07:28 PM |
| WILLIAMS NICOLE | Director | Mar 20, 2015 | Option Exercise | $9.82 | 973 | 9,557 | 1,935 | Mar 24, 2015, 09:00 PM |
| WILLIAMS NICOLE | Director | Mar 20, 2015 | Sale | $305.36 | 973 | 297,115 | 962 | Mar 24, 2015, 09:00 PM |
| Shapiro David | CMO and EVP - Development | Mar 16, 2015 | Option Exercise | $10.40 | 3,500 | 36,400 | 22,296 | Mar 18, 2015, 09:00 PM |
| Shapiro David | CMO and EVP - Development | Mar 16, 2015 | Sale | $286.90 | 3,500 | 1,004,140 | 21,296 | Mar 18, 2015, 09:00 PM |
| Shapiro David | CMO and EVP - Development | Mar 12, 2015 | Option Exercise | $8.67 | 5,000 | 43,334 | 23,796 | Mar 16, 2015, 09:00 PM |
| Shapiro David | CMO and EVP - Development | Mar 12, 2015 | Sale | $285.99 | 5,000 | 1,429,935 | 18,796 | Mar 16, 2015, 09:00 PM |
| VEITINGER KLAUS R DR | Director | Mar 10, 2015 | Option Exercise | $21.50 | 391 | 8,407 | 2,557 | Mar 12, 2015, 09:00 PM |
| VEITINGER KLAUS R DR | Director | Mar 10, 2015 | Sale | $262.06 | 391 | 102,465 | 2,324 | Mar 12, 2015, 09:00 PM |
| VEITINGER KLAUS R DR | Director | Feb 24, 2015 | Option Exercise | $21.50 | 632 | 13,588 | 2,798 | Feb 26, 2015, 09:00 PM |
| VEITINGER KLAUS R DR | Director | Feb 24, 2015 | Sale | $222.50 | 632 | 140,620 | 2,166 | Feb 26, 2015, 09:00 PM |
| WILLIAMS NICOLE | Director | Feb 20, 2015 | Option Exercise | $9.82 | 974 | 9,567 | 1,936 | Feb 24, 2015, 09:00 PM |
| WILLIAMS NICOLE | Director | Feb 20, 2015 | Sale | $216.00 | 974 | 210,384 | 962 | Feb 24, 2015, 09:00 PM |
| Shapiro David | CMO and EVP - Development | Feb 17, 2015 | Option Exercise | $9.36 | 8,794 | 82,282 | 23,442 | Feb 19, 2015, 09:02 PM |
| Shapiro David | CMO and EVP - Development | Feb 17, 2015 | Sale | $209.41 | 4,646 | 972,921 | 21,942 | Feb 19, 2015, 09:02 PM |
| VEITINGER KLAUS R DR | Director | Feb 10, 2015 | Option Exercise | $21.50 | 233 | 5,010 | 2,399 | Feb 12, 2015, 09:00 PM |
| VEITINGER KLAUS R DR | Director | Feb 10, 2015 | Sale | $195.52 | 233 | 45,556 | 2,166 | Feb 12, 2015, 09:00 PM |
| Regan Daniel Paul | Chief Commercial Officer | Jan 30, 2015 | Option Exercise | $37.69 | 9,847 | 371,133 | 11,111 | Feb 03, 2015, 09:01 PM |
| Regan Daniel Paul | Chief Commercial Officer | Jan 30, 2015 | Sale | $201.07 | 9,847 | 1,979,964 | 4,264 | Feb 03, 2015, 09:01 PM |
| Shapiro David | CMO and EVP - Development | Jan 30, 2015 | Option Exercise | $9.48 | 7,500 | 71,067 | 22,148 | Feb 03, 2015, 09:00 PM |
| Shapiro David | CMO and EVP - Development | Jan 30, 2015 | Sale | $205.84 | 7,500 | 1,543,833 | 19,048 | Feb 03, 2015, 09:00 PM |
| WILLIAMS NICOLE | Director | Jan 20, 2015 | Option Exercise | $9.82 | 973 | 9,557 | 2,438 | Jan 22, 2015, 09:00 PM |
| WILLIAMS NICOLE | Director | Jan 20, 2015 | Sale | $151.32 | 973 | 147,234 | 1,465 | Jan 22, 2015, 09:00 PM |
| VEITINGER KLAUS R DR | Director | Jan 12, 2015 | Option Exercise | $21.50 | 233 | 5,010 | 2,399 | Jan 14, 2015, 09:00 PM |
| VEITINGER KLAUS R DR | Director | Jan 12, 2015 | Sale | $150.01 | 233 | 34,952 | 2,166 | Jan 14, 2015, 09:00 PM |
| Regan Daniel Paul | Chief Commercial Officer | Jan 05, 2015 | Sale | $176.49 | 146 | 25,767 | 1,264 | Jan 07, 2015, 09:03 PM |
| Pruzanski Mark | CEO & President | Jan 05, 2015 | Sale | $176.49 | 461 | 81,360 | 491,032 | Jan 07, 2015, 09:02 PM |
| Shapiro David | CMO and EVP - Development | Jan 05, 2015 | Sale | $172.63 | 664 | 114,627 | 14,648 | Jan 07, 2015, 09:01 PM |
| Duncan Barbara Gayle | Chief Financial Officer | Jan 05, 2015 | Sale | $176.49 | 141 | 24,885 | 17,264 | Jan 07, 2015, 09:00 PM |
| Shapiro David | CMO and EVP - Development | Jan 02, 2015 | Sale | $158.71 | 376 | 59,675 | 15,312 | Jan 05, 2015, 09:01 PM |
| Duncan Barbara Gayle | Chief Financial Officer | Jan 02, 2015 | Option Exercise | $31.90 | 1,000 | 31,900 | 18,405 | Jan 05, 2015, 09:00 PM |
| Duncan Barbara Gayle | Chief Financial Officer | Jan 02, 2015 | Sale | $156.40 | 1,000 | 156,400 | 17,905 | Jan 05, 2015, 09:00 PM |
| Benatti Luca | Director | Dec 15, 2014 | Buy | $139.86 | 800 | 111,888 | 1,292 | Dec 15, 2014, 09:00 PM |
| VEITINGER KLAUS R DR | Director | Dec 10, 2014 | Option Exercise | $21.50 | 233 | 5,010 | 2,399 | Dec 12, 2014, 09:00 PM |
| VEITINGER KLAUS R DR | Director | Dec 10, 2014 | Sale | $144.16 | 233 | 33,589 | 2,166 | Dec 12, 2014, 09:00 PM |
| Pruzanski Mark | CEO & President | Nov 19, 2014 | Option Exercise | $8.73 | 6,716 | 58,603 | 486,625 | Nov 20, 2014, 09:00 PM |
| Shapiro David | CMO and EVP - Development | Nov 17, 2014 | Option Exercise | $10.40 | 4,000 | 41,600 | 18,855 | Nov 19, 2014, 09:00 PM |
| Shapiro David | CMO and EVP - Development | Nov 17, 2014 | Sale | $158.82 | 4,790 | 760,730 | 17,855 | Nov 19, 2014, 09:00 PM |
| AKKARAJU SRINIVAS | Director | Nov 11, 2014 | Option Exercise | $21.50 | 2,500 | 53,750 | 5,642 | Nov 13, 2014, 09:32 AM |
| AKKARAJU SRINIVAS | Director | Nov 12, 2014 | Buy | $167.19 | 2,000 | 334,386 | 7,642 | Nov 13, 2014, 09:32 AM |
| VEITINGER KLAUS R DR | Director | Nov 10, 2014 | Option Exercise | $21.50 | 233 | 5,010 | 2,399 | Nov 12, 2014, 09:00 PM |
| VEITINGER KLAUS R DR | Director | Nov 10, 2014 | Sale | $175.95 | 233 | 40,996 | 2,166 | Nov 12, 2014, 09:00 PM |
| Pruzanski Mark | CEO & President | Nov 03, 2014 | Option Exercise | $8.67 | 10,000 | 86,667 | 489,909 | Nov 05, 2014, 09:00 PM |
| Pruzanski Mark | CEO & President | Nov 03, 2014 | Sale | $259.41 | 10,000 | 2,594,124 | 489,809 | Nov 05, 2014, 09:00 PM |
| VEITINGER KLAUS R DR | Director | Oct 10, 2014 | Option Exercise | $21.50 | 391 | 8,407 | 2,557 | Oct 15, 2014, 09:00 PM |
| VEITINGER KLAUS R DR | Director | Oct 10, 2014 | Sale | $223.65 | 391 | 87,447 | 2,166 | Oct 15, 2014, 09:00 PM |
| Duncan Barbara Gayle | Chief Financial Officer | Oct 01, 2014 | Option Exercise | $31.90 | 1,000 | 31,900 | 17,107 | Oct 03, 2014, 09:01 PM |
| Duncan Barbara Gayle | Chief Financial Officer | Oct 01, 2014 | Sale | $233.12 | 1,000 | 233,119 | 16,207 | Oct 03, 2014, 09:01 PM |
| Shapiro David | CMO and EVP - Development | Oct 01, 2014 | Option Exercise | $10.40 | 4,000 | 41,600 | 19,875 | Oct 03, 2014, 09:00 PM |
| Shapiro David | CMO and EVP - Development | Oct 02, 2014 | Sale | $233.97 | 832 | 194,664 | 14,855 | Oct 03, 2014, 09:00 PM |
| Shapiro David | CMO and EVP - Development | Oct 01, 2014 | Sale | $231.17 | 4,188 | 968,130 | 19,375 | Oct 03, 2014, 09:00 PM |
| Pruzanski Mark | CEO & President | Oct 01, 2014 | Option Exercise | $8.67 | 10,000 | 86,667 | 489,909 | Oct 03, 2014, 09:00 PM |
| Pruzanski Mark | CEO & President | Oct 01, 2014 | Sale | $228.82 | 10,000 | 2,288,187 | 488,509 | Oct 03, 2014, 09:00 PM |
| Shapiro David | CMO and EVP - Development | Sep 15, 2014 | Option Exercise | $10.40 | 4,000 | 41,600 | 18,253 | Sep 17, 2014, 09:04 PM |
| Shapiro David | CMO and EVP - Development | Sep 15, 2014 | Sale | $281.19 | 4,000 | 1,124,752 | 15,253 | Sep 17, 2014, 09:04 PM |
| VEITINGER KLAUS R DR | Director | Sep 10, 2014 | Option Exercise | $21.50 | 391 | 8,407 | 2,557 | Sep 12, 2014, 09:00 PM |
| VEITINGER KLAUS R DR | Director | Sep 10, 2014 | Sale | $280.50 | 391 | 109,676 | 2,166 | Sep 12, 2014, 09:00 PM |
| Pruzanski Mark | CEO & President | Sep 02, 2014 | Option Exercise | $8.67 | 10,000 | 86,667 | 485,042 | Sep 04, 2014, 09:11 PM |
| Pruzanski Mark | CEO & President | Sep 02, 2014 | Sale | $286.49 | 10,000 | 2,864,883 | 481,442 | Sep 04, 2014, 09:11 PM |
| Shapiro David | CMO and EVP - Development | Aug 27, 2014 | Option Exercise | $8.67 | 10,000 | 86,667 | 24,253 | Aug 29, 2014, 09:00 PM |
| Shapiro David | CMO and EVP - Development | Aug 27, 2014 | Sale | $293.93 | 10,000 | 2,939,282 | 20,403 | Aug 29, 2014, 09:00 PM |
| SILVERSTEIN JONATHAN | Director | Aug 26, 2014 | Sale | $300.07 | 61,258 | 18,381,588 | 1,536,182 | Aug 27, 2014, 09:06 PM |
| SILVERSTEIN JONATHAN | Director | Aug 25, 2014 | Sale | $295.59 | 50,000 | 14,779,499 | 1,584,024 | Aug 27, 2014, 09:06 PM |
| ORBIMED ADVISORS LLC | Director | Aug 26, 2014 | Sale | $300.07 | 61,258 | 18,381,588 | 1,536,182 | Aug 27, 2014, 09:05 PM |
| ORBIMED ADVISORS LLC | Director | Aug 25, 2014 | Sale | $295.59 | 50,000 | 14,779,499 | 1,584,024 | Aug 27, 2014, 09:05 PM |
| WILLIAMS NICOLE | Director | Aug 25, 2014 | Sale | $295.08 | 2,433 | 717,919 | 2,465 | Aug 27, 2014, 09:00 PM |
| SILVERSTEIN JONATHAN | Director | Aug 14, 2014 | Sale | $299.82 | 60,000 | 17,989,207 | 1,652,878 | Aug 18, 2014, 09:13 PM |
| ORBIMED ADVISORS LLC | Director | Aug 14, 2014 | Sale | $299.82 | 60,000 | 17,989,207 | 1,652,878 | Aug 18, 2014, 09:07 PM |
| Shapiro David | CMO and EVP - Development | Aug 15, 2014 | Option Exercise | $10.40 | 4,000 | 41,600 | 19,027 | Aug 15, 2014, 09:00 PM |
| Shapiro David | CMO and EVP - Development | Aug 15, 2014 | Sale | $291.49 | 4,774 | 1,391,568 | 18,253 | Aug 15, 2014, 09:00 PM |
| Regan Daniel Paul | Chief Commercial Officer | Aug 12, 2014 | Option Exercise | $37.69 | 8,124 | 306,194 | 9,534 | Aug 15, 2014, 09:00 PM |
| Regan Daniel Paul | Chief Commercial Officer | Aug 12, 2014 | Sale | $325.70 | 8,124 | 2,645,963 | 9,334 | Aug 15, 2014, 09:00 PM |
| VEITINGER KLAUS R DR | Director | Aug 12, 2014 | Option Exercise | $21.50 | 316 | 6,794 | 2,482 | Aug 15, 2014, 09:00 PM |
| VEITINGER KLAUS R DR | Director | Aug 12, 2014 | Sale | $345.62 | 316 | 109,216 | 2,166 | Aug 15, 2014, 09:00 PM |
| Adorini Luciano | Chief Scientific Officer | Aug 12, 2014 | Option Exercise | $8.67 | 11,038 | 95,663 | 19,151 | Aug 15, 2014, 09:00 PM |
| Adorini Luciano | Chief Scientific Officer | Aug 12, 2014 | Sale | $321.62 | 11,038 | 3,550,078 | 18,751 | Aug 15, 2014, 09:00 PM |
| Fundaro Paolo | Director | Aug 11, 2014 | Sale | $239.49 | 324 | 77,595 | 8,803 | Aug 12, 2014, 09:03 PM |
| VEITINGER KLAUS R DR | Director | Aug 11, 2014 | Option Exercise | $21.50 | 391 | 8,407 | 2,557 | Aug 12, 2014, 09:00 PM |
| VEITINGER KLAUS R DR | Director | Aug 11, 2014 | Sale | $238.72 | 555 | 132,488 | 2,266 | Aug 12, 2014, 09:00 PM |
| Pruzanski Mark | CEO & President | Aug 01, 2014 | Option Exercise | $8.67 | 10,000 | 86,667 | 485,042 | Aug 06, 2014, 09:00 PM |
| Pruzanski Mark | CEO & President | Aug 01, 2014 | Sale | $226.72 | 10,000 | 2,267,200 | 475,042 | Aug 06, 2014, 09:00 PM |
| VEITINGER KLAUS R DR | Director | Jul 10, 2014 | Option Exercise | $21.50 | 391 | 8,407 | 2,171 | Jul 11, 2014, 09:00 PM |
| VEITINGER KLAUS R DR | Director | Jul 10, 2014 | Sale | $219.15 | 391 | 85,688 | 1,938 | Jul 11, 2014, 09:00 PM |
| TALLARIGO LORENZO | Director | Jul 07, 2014 | Option Exercise | $9.82 | 2,000 | 19,645 | 2,000 | Jul 09, 2014, 09:00 PM |
| TALLARIGO LORENZO | Director | Jul 07, 2014 | Sale | $243.06 | 2,000 | 486,110 | 1,000 | Jul 09, 2014, 09:00 PM |
| Regan Daniel Paul | Chief Commercial Officer | Jul 03, 2014 | Option Exercise | $37.69 | 1 | 38 | 1,411 | Jul 08, 2014, 09:00 PM |
| Regan Daniel Paul | Chief Commercial Officer | Jul 03, 2014 | Sale | $250.00 | 1 | 250 | 1,410 | Jul 08, 2014, 09:00 PM |
| Shapiro David | CMO and EVP - Development | Jul 01, 2014 | Option Exercise | $10.40 | 4,000 | 41,600 | 20,063 | Jul 03, 2014, 09:01 PM |
| Shapiro David | CMO and EVP - Development | Jul 02, 2014 | Sale | $247.65 | 849 | 210,257 | 15,027 | Jul 03, 2014, 09:01 PM |
| Shapiro David | CMO and EVP - Development | Jul 01, 2014 | Sale | $244.14 | 4,187 | 1,022,194 | 18,876 | Jul 03, 2014, 09:01 PM |
| Pruzanski Mark | CEO & President | Jul 01, 2014 | Option Exercise | $8.67 | 10,000 | 86,667 | 485,042 | Jul 03, 2014, 09:01 PM |
| Pruzanski Mark | CEO & President | Jul 01, 2014 | Sale | $250.61 | 10,000 | 2,506,120 | 475,042 | Jul 03, 2014, 09:01 PM |
| Shapiro David | CMO and EVP - Development | Jun 16, 2014 | Option Exercise | $10.40 | 4,000 | 41,600 | 18,440 | Jun 18, 2014, 09:02 PM |
| Shapiro David | CMO and EVP - Development | Jun 16, 2014 | Sale | $278.15 | 4,000 | 1,112,587 | 17,440 | Jun 18, 2014, 09:02 PM |
| Pruzanski Mark | CEO & President | Jun 02, 2014 | Option Exercise | $8.67 | 10,000 | 86,667 | 480,174 | Jun 04, 2014, 09:00 PM |
| Pruzanski Mark | CEO & President | Jun 02, 2014 | Sale | $230.60 | 10,000 | 2,305,990 | 470,174 | Jun 04, 2014, 09:00 PM |
| Fundaro Paolo | Director | May 15, 2014 | Option Exercise | $9.82 | 6,922 | 67,990 | 8,577 | May 19, 2014, 09:02 PM |
| Shapiro David | CMO and EVP - Development | May 15, 2014 | Option Exercise | $10.40 | 4,000 | 41,600 | 19,183 | May 19, 2014, 09:00 PM |
| Shapiro David | CMO and EVP - Development | May 15, 2014 | Sale | $276.03 | 4,743 | 1,309,199 | 18,440 | May 19, 2014, 09:00 PM |
| Fundaro Paolo | Director | May 09, 2014 | Sale | $232.00 | 325 | 75,400 | 1,655 | May 09, 2014, 09:03 PM |
| VEITINGER KLAUS R DR | Director | May 09, 2014 | Sale | $230.95 | 162 | 37,414 | 1,880 | May 09, 2014, 09:02 PM |
| VEITINGER KLAUS R DR | Director | May 07, 2014 | Sale | $254.36 | 665 | 169,150 | 2,182 | May 09, 2014, 09:02 PM |
| TALLARIGO LORENZO | Director | May 09, 2014 | Sale | $232.00 | 367 | 85,144 | 0 | May 09, 2014, 09:01 PM |
| TALLARIGO LORENZO | Director | May 07, 2014 | Sale | $259.76 | 1,640 | 426,008 | 1,000 | May 09, 2014, 09:01 PM |
| Adorini Luciano | Chief Scientific Officer | May 07, 2014 | Option Exercise | $10.40 | 2,000 | 20,800 | 9,464 | May 09, 2014, 09:00 PM |
| Adorini Luciano | Chief Scientific Officer | May 07, 2014 | Sale | $259.44 | 2,000 | 518,875 | 8,464 | May 09, 2014, 09:00 PM |
| Pruzanski Mark | CEO & President | May 01, 2014 | Option Exercise | $8.67 | 10,000 | 86,667 | 480,174 | May 02, 2014, 09:02 PM |
| Pruzanski Mark | CEO & President | May 01, 2014 | Sale | $263.17 | 10,000 | 2,631,660 | 470,174 | May 02, 2014, 09:02 PM |
| Pruzanski Mark | CEO & President | Apr 16, 2014 | Option Exercise | $8.67 | 10,000 | 86,667 | 480,174 | Apr 17, 2014, 09:00 PM |
| Pruzanski Mark | CEO & President | Apr 15, 2014 | Option Exercise | $6.17 | 30,309 | 186,926 | 470,174 | Apr 17, 2014, 09:00 PM |
| Pruzanski Mark | CEO & President | Apr 16, 2014 | Sale | $242.22 | 10,000 | 2,422,170 | 470,174 | Apr 17, 2014, 09:00 PM |
| Duncan Barbara Gayle | Chief Financial Officer | Apr 14, 2014 | Option Exercise | $21.50 | 1,154 | 24,811 | 14,664 | Apr 15, 2014, 09:01 PM |
| Duncan Barbara Gayle | Chief Financial Officer | Apr 14, 2014 | Sale | $279.00 | 1,154 | 321,966 | 13,510 | Apr 15, 2014, 09:01 PM |
| Micheli Francesco | 10% Owner | Apr 10, 2014 | Sale | $293.91 | 30,623 | 9,000,406 | 6,454,953 | Apr 11, 2014, 09:03 PM |
| Micheli Francesco | 10% Owner | Apr 09, 2014 | Sale | $320.00 | 318,695 | 101,982,400 | 5,620,195 | Apr 11, 2014, 09:03 PM |
| Micheli Francesco | 10% Owner | Apr 10, 2014 | Option Exercise | $10.40 | 865,381 | 8,999,962 | 6,485,576 | Apr 11, 2014, 09:03 PM |
| Genextra S.p.A. | 10% Owner | Apr 10, 2014 | Sale | $293.91 | 30,623 | 9,000,406 | 6,454,953 | Apr 11, 2014, 09:02 PM |
| Genextra S.p.A. | 10% Owner | Apr 09, 2014 | Sale | $320.00 | 318,695 | 101,982,400 | 5,620,195 | Apr 11, 2014, 09:02 PM |
| Genextra S.p.A. | 10% Owner | Apr 10, 2014 | Option Exercise | $10.40 | 865,381 | 8,999,962 | 6,485,576 | Apr 11, 2014, 09:02 PM |
| TALLARIGO LORENZO | Director | Apr 10, 2014 | Sale | $293.91 | 30,623 | 9,000,406 | 6,454,953 | Apr 11, 2014, 09:01 PM |
| TALLARIGO LORENZO | Director | Apr 09, 2014 | Sale | $320.00 | 318,695 | 101,982,400 | 5,620,195 | Apr 11, 2014, 09:01 PM |
| TALLARIGO LORENZO | Director | Apr 10, 2014 | Option Exercise | $10.40 | 865,381 | 8,999,962 | 6,485,576 | Apr 11, 2014, 09:01 PM |
| SILVERSTEIN JONATHAN | Director | Apr 09, 2014 | Sale | $320.00 | 81,305 | 26,017,600 | 1,653,629 | Apr 11, 2014, 09:00 PM |
| ORBIMED ADVISORS LLC | Director | Apr 09, 2014 | Sale | $320.00 | 81,305 | 26,017,600 | 1,654,603 | Apr 11, 2014, 05:27 PM |
| Adorini Luciano | Chief Scientific Officer | Apr 07, 2014 | Option Exercise | $10.40 | 2,000 | 20,800 | 9,041 | Apr 09, 2014, 09:00 PM |
| Adorini Luciano | Chief Scientific Officer | Apr 07, 2014 | Sale | $283.90 | 2,000 | 567,800 | 8,541 | Apr 09, 2014, 09:00 PM |
| Shapiro David | CMO and EVP - Development | Apr 01, 2014 | Option Exercise | $10.40 | 4,326 | 44,991 | 19,072 | Apr 03, 2014, 09:01 PM |
| Shapiro David | CMO and EVP - Development | Apr 02, 2014 | Sale | $321.95 | 879 | 282,997 | 13,679 | Apr 03, 2014, 09:01 PM |
| Shapiro David | CMO and EVP - Development | Apr 01, 2014 | Sale | $333.76 | 4,514 | 1,506,588 | 18,072 | Apr 03, 2014, 09:01 PM |
| Shapiro David | CMO and EVP - Development | Mar 17, 2014 | Option Exercise | $10.40 | 8,917 | 92,738 | 17,580 | Mar 19, 2014, 09:00 PM |
| Shapiro David | CMO and EVP - Development | Mar 17, 2014 | Sale | $437.49 | 4,456 | 1,949,450 | 17,124 | Mar 19, 2014, 09:00 PM |
| Adorini Luciano | Chief Scientific Officer | Mar 07, 2014 | Option Exercise | $10.40 | 2,000 | 20,800 | 8,392 | Mar 11, 2014, 09:00 PM |
| Adorini Luciano | Chief Scientific Officer | Mar 07, 2014 | Sale | $421.31 | 2,000 | 842,620 | 6,392 | Mar 11, 2014, 09:00 PM |
| Regan Daniel Paul | Chief Commercial Officer | Mar 05, 2014 | Option Exercise | $37.69 | 20,000 | 753,800 | 20,000 | Mar 07, 2014, 09:00 PM |
| Regan Daniel Paul | Chief Commercial Officer | Mar 05, 2014 | Sale | $434.69 | 20,000 | 8,693,823 | 19,500 | Mar 07, 2014, 09:00 PM |
| Shapiro David | CMO and EVP - Development | Feb 14, 2014 | Option Exercise | $10.40 | 4,327 | 45,001 | 12,990 | Feb 18, 2014, 09:46 PM |
| Shapiro David | CMO and EVP - Development | Feb 14, 2014 | Sale | $367.11 | 5,772 | 2,118,948 | 11,358 | Feb 18, 2014, 09:46 PM |
| Fundaro Paolo | Director | Feb 12, 2014 | Option Exercise | $8.67 | 6,922 | 59,991 | 8,901 | Feb 14, 2014, 09:00 PM |
| Fundaro Paolo | Director | Feb 12, 2014 | Sale | $375.62 | 6,922 | 2,600,029 | 8,401 | Feb 14, 2014, 09:00 PM |
| Fundaro Paolo | Director | Feb 14, 2014 | Sale | $367.51 | 324 | 119,073 | 1,655 | Feb 14, 2014, 09:00 PM |
| VEITINGER KLAUS R DR | Director | Feb 10, 2014 | Sale | $377.72 | 162 | 61,190 | 2,344 | Feb 11, 2014, 09:02 PM |
| TALLARIGO LORENZO | Director | Feb 10, 2014 | Sale | $354.52 | 368 | 130,463 | 1,640 | Feb 11, 2014, 09:02 PM |
| Adorini Luciano | Chief Scientific Officer | Feb 07, 2014 | Option Exercise | $10.40 | 2,000 | 20,800 | 8,392 | Feb 11, 2014, 09:00 PM |
| Adorini Luciano | Chief Scientific Officer | Feb 07, 2014 | Sale | $305.15 | 2,000 | 610,300 | 7,392 | Feb 11, 2014, 09:00 PM |
| AKKARAJU SRINIVAS | Director | Jan 16, 2014 | Option Exercise | $21.50 | 2,500 | 53,750 | 5,193 | Jan 17, 2014, 09:01 PM |
| AKKARAJU SRINIVAS | Director | Jan 16, 2014 | Sale | $267.94 | 3,250 | 870,805 | 1,943 | Jan 17, 2014, 09:01 PM |
| Duncan Barbara Gayle | Chief Financial Officer | Jan 15, 2014 | Option Exercise | $31.90 | 5,625 | 179,437 | 16,333 | Jan 17, 2014, 09:01 PM |
| Duncan Barbara Gayle | Chief Financial Officer | Jan 15, 2014 | Sale | $259.18 | 5,625 | 1,457,915 | 16,033 | Jan 17, 2014, 09:01 PM |
| Pruzanski Mark | President and CEO | Jan 16, 2014 | Option Exercise | $8.67 | 10,000 | 86,667 | 440,298 | Jan 17, 2014, 09:00 PM |
| Pruzanski Mark | President and CEO | Jan 16, 2014 | Sale | $273.68 | 10,000 | 2,736,770 | 430,298 | Jan 17, 2014, 09:00 PM |
| Pruzanski Mark | President and CEO | Dec 30, 2013 | Option Exercise | $2.89 | 21,503 | 62,120 | 438,138 | Jan 17, 2014, 09:00 PM |
| Shapiro David | CMO and EVP - Development | Jan 08, 2014 | Option Exercise | $9.67 | 8,968 | 86,681 | 13,591 | Jan 10, 2014, 09:00 PM |
| Shapiro David | CMO and EVP - Development | Jan 08, 2014 | Sale | $71.85 | 4,928 | 354,065 | 9,591 | Jan 10, 2014, 09:00 PM |
| Adorini Luciano | Chief Scientific Officer | Jan 07, 2014 | Option Exercise | $10.40 | 1,634 | 16,994 | 8,026 | Jan 09, 2014, 09:30 PM |
| Adorini Luciano | Chief Scientific Officer | Jan 07, 2014 | Sale | $67.41 | 1,634 | 110,148 | 6,392 | Jan 09, 2014, 09:30 PM |
| TALLARIGO LORENZO | Director | Jan 07, 2014 | Sale | $67.41 | 1,839 | 123,967 | 1,640 | Jan 09, 2014, 09:30 PM |
| AKKARAJU SRINIVAS | Director | Dec 18, 2013 | Sale | $55.53 | 260 | 14,437 | 2,368 | Dec 19, 2013, 09:00 PM |
| Shapiro David | CMO & EVP - Development | Dec 16, 2013 | Option Exercise | $10.40 | 3,750 | 39,000 | 8,016 | Dec 17, 2013, 09:00 PM |
| Shapiro David | CMO & EVP - Development | Dec 16, 2013 | Sale | $62.11 | 5,016 | 311,550 | 3,000 | Dec 17, 2013, 09:00 PM |
| Adorini Luciano | Chief Scientific Officer | Nov 20, 2013 | Option Exercise | $10.40 | 2,000 | 20,800 | 7,743 | Nov 25, 2013, 06:02 AM |
| Adorini Luciano | Chief Scientific Officer | Nov 20, 2013 | Sale | $50.64 | 2,000 | 101,285 | 6,123 | Nov 25, 2013, 06:02 AM |
| Shapiro David | CMO & EVP - Development | Nov 15, 2013 | Option Exercise | $10.40 | 3,750 | 39,000 | 8,996 | Nov 19, 2013, 09:30 PM |
| Shapiro David | CMO & EVP - Development | Nov 15, 2013 | Sale | $48.08 | 4,730 | 227,412 | 4,266 | Nov 19, 2013, 09:30 PM |
| VEITINGER KLAUS R DR | Director | Nov 11, 2013 | Sale | $48.93 | 162 | 7,927 | 2,220 | Nov 12, 2013, 09:31 PM |
| ORBIMED ADVISORS LLC | Director | Oct 21, 2013 | Sale | $62.50 | 40,088 | 2,505,500 | 1,735,259 | Oct 23, 2013, 09:32 PM |
| Genextra S.p.A. | 10% Owner | Oct 21, 2013 | Sale | $62.50 | 124,912 | 7,807,000 | 5,938,890 | Oct 23, 2013, 09:32 PM |
| Micheli Francesco | 10% Owner | Oct 21, 2013 | Sale | $62.50 | 124,912 | 7,807,000 | 5,938,890 | Oct 23, 2013, 09:32 PM |
| Adorini Luciano | Chief Scientific Officer | Oct 21, 2013 | Option Exercise | $10.40 | 2,000 | 20,800 | 7,743 | Oct 23, 2013, 09:31 PM |
| Adorini Luciano | Chief Scientific Officer | Oct 21, 2013 | Sale | $55.51 | 2,000 | 111,027 | 5,743 | Oct 23, 2013, 09:31 PM |
| TALLARIGO LORENZO | Director | Oct 21, 2013 | Sale | $62.50 | 124,912 | 7,807,000 | 5,938,890 | Oct 23, 2013, 09:31 PM |
| SILVERSTEIN JONATHAN | Director | Oct 21, 2013 | Sale | $62.50 | 40,088 | 2,505,500 | 1,734,934 | Oct 23, 2013, 09:30 PM |
| TALLARIGO LORENZO | Director | Oct 15, 2013 | Sale | $62.50 | 1,123,415 | 70,213,438 | 6,063,802 | Oct 17, 2013, 09:33 PM |
| SILVERSTEIN JONATHAN | Director | Oct 15, 2013 | Sale | $62.50 | 376,585 | 23,536,563 | 1,775,022 | Oct 17, 2013, 09:32 PM |
| Genextra S.p.A. | 10% Owner | Oct 15, 2013 | Sale | $62.50 | 1,123,415 | 70,213,438 | 6,063,802 | Oct 17, 2013, 09:31 PM |
| Micheli Francesco | 10% Owner | Oct 15, 2013 | Sale | $62.50 | 1,123,415 | 70,213,438 | 6,063,802 | Oct 17, 2013, 09:31 PM |
| ORBIMED ADVISORS LLC | Director | Oct 15, 2013 | Sale | $62.50 | 376,585 | 23,536,563 | 1,775,347 | Oct 17, 2013, 09:28 PM |
| VEITINGER KLAUS R DR | Director | Oct 01, 2013 | Sale | $73.42 | 671 | 49,261 | 2,528 | Oct 03, 2013, 09:32 PM |
| Shapiro David | CMO & EVP - Development | Oct 02, 2013 | Option Exercise | $10.40 | 3,750 | 39,000 | 9,638 | Oct 03, 2013, 09:30 PM |
| Shapiro David | CMO & EVP - Development | Oct 02, 2013 | Sale | $72.80 | 4,392 | 319,720 | 7,665 | Oct 03, 2013, 09:30 PM |
| Adorini Luciano | Chief Scientific Officer | Sep 20, 2013 | Option Exercise | $10.40 | 2,000 | 20,800 | 7,094 | Sep 20, 2013, 09:30 PM |
| Adorini Luciano | Chief Scientific Officer | Sep 20, 2013 | Sale | $61.07 | 2,000 | 122,134 | 5,094 | Sep 20, 2013, 09:30 PM |
| Pruzanski Mark | President and CEO | Sep 17, 2013 | Option Exercise | $9.82 | 25,000 | 245,557 | 427,032 | Sep 18, 2013, 09:31 PM |
| Pruzanski Mark | President and CEO | Sep 17, 2013 | Sale | $52.00 | 25,000 | 1,300,000 | 402,032 | Sep 18, 2013, 09:31 PM |
| Shapiro David | CMO & EVP - Development | Sep 16, 2013 | Option Exercise | $10.40 | 3,750 | 39,000 | 9,282 | Sep 18, 2013, 09:30 PM |
| Shapiro David | CMO & EVP - Development | Aug 16, 2013 | Sale | $49.20 | 5,016 | 246,784 | 4,266 | Sep 18, 2013, 09:30 PM |
| Pruzanski Mark | President and CEO | Sep 13, 2013 | Option Exercise | $9.82 | 11,600 | 113,939 | 413,632 | Sep 13, 2013, 09:31 PM |
| Pruzanski Mark | President and CEO | Sep 12, 2013 | Option Exercise | $9.82 | 900 | 8,840 | 402,932 | Sep 13, 2013, 09:31 PM |
| Pruzanski Mark | President and CEO | Sep 12, 2013 | Sale | $49.65 | 900 | 44,684 | 402,032 | Sep 13, 2013, 09:31 PM |
| Pruzanski Mark | President and CEO | Sep 13, 2013 | Sale | $48.97 | 11,600 | 568,010 | 411,836 | Sep 13, 2013, 09:31 PM |
| WILLIAMS NICOLE | Director | Sep 05, 2013 | Sale | $46.43 | 600 | 27,856 | 2,201 | Sep 06, 2013, 09:30 PM |
| Adorini Luciano | Chief Scientific Officer | Aug 20, 2013 | Option Exercise | $10.40 | 2,000 | 20,800 | 7,094 | Aug 22, 2013, 09:30 PM |
| Adorini Luciano | Chief Scientific Officer | Aug 20, 2013 | Sale | $44.18 | 2,000 | 88,360 | 5,094 | Aug 22, 2013, 09:30 PM |
| Shapiro David | CMO & EVP - Development | Aug 15, 2013 | Option Exercise | $10.40 | 3,750 | 39,000 | 7,286 | Aug 16, 2013, 09:30 PM |
| Shapiro David | CMO & EVP - Development | Aug 15, 2013 | Sale | $45.04 | 4,754 | 214,120 | 2,532 | Aug 16, 2013, 09:30 PM |
| Pruzanski Mark | President and CEO | Aug 12, 2013 | Option Exercise | $9.82 | 12,500 | 122,779 | 414,532 | Aug 13, 2013, 09:31 PM |
| Pruzanski Mark | President and CEO | Aug 12, 2013 | Sale | $45.98 | 12,500 | 574,724 | 402,032 | Aug 13, 2013, 09:31 PM |
| Fundaro Paolo | Director | Aug 12, 2013 | Option Exercise | $10.11 | 3,461 | 34,995 | 6,089 | Aug 13, 2013, 09:30 PM |
| Fundaro Paolo | Director | Aug 12, 2013 | Sale | $46.13 | 4,759 | 219,552 | 5,289 | Aug 13, 2013, 09:30 PM |
| Adorini Luciano | Chief Scientific Officer | Jul 22, 2013 | Option Exercise | $10.40 | 2,000 | 20,800 | 7,094 | Jul 24, 2013, 09:30 PM |
| Adorini Luciano | Chief Scientific Officer | Jul 22, 2013 | Sale | $49.44 | 2,000 | 98,884 | 6,094 | Jul 24, 2013, 09:30 PM |
| Pruzanski Mark | President and CEO | Jul 15, 2013 | Option Exercise | $9.82 | 21,700 | 213,144 | 423,732 | Jul 16, 2013, 09:31 PM |
| Pruzanski Mark | President and CEO | Jul 12, 2013 | Option Exercise | $9.82 | 3,300 | 32,414 | 405,332 | Jul 16, 2013, 09:31 PM |
| Pruzanski Mark | President and CEO | Jul 15, 2013 | Sale | $49.85 | 21,700 | 1,081,683 | 403,691 | Jul 16, 2013, 09:31 PM |
| Pruzanski Mark | President and CEO | Jul 12, 2013 | Sale | $51.35 | 3,300 | 169,445 | 403,332 | Jul 16, 2013, 09:31 PM |
| Duncan Barbara Gayle | Chief Financial Officer | Jul 08, 2013 | Option Exercise | $9.82 | 25,000 | 245,557 | 33,112 | Jul 10, 2013, 09:33 PM |
| Duncan Barbara Gayle | Chief Financial Officer | Jul 08, 2013 | Sale | $45.39 | 25,000 | 1,134,840 | 8,112 | Jul 10, 2013, 09:33 PM |
| Pruzanski Mark | President and CEO | Jul 09, 2013 | Option Exercise | $9.82 | 12,500 | 122,779 | 414,532 | Jul 10, 2013, 09:32 PM |
| Pruzanski Mark | President and CEO | Jul 08, 2013 | Option Exercise | $9.82 | 25,000 | 245,557 | 427,032 | Jul 10, 2013, 09:32 PM |
| Pruzanski Mark | President and CEO | Jul 08, 2013 | Sale | $45.41 | 25,000 | 1,135,200 | 402,032 | Jul 10, 2013, 09:32 PM |
| Pruzanski Mark | President and CEO | Jul 09, 2013 | Sale | $48.26 | 12,500 | 603,259 | 402,032 | Jul 10, 2013, 09:32 PM |
| Shapiro David | CMO & EVP - Development | Jul 02, 2013 | Option Exercise | $10.40 | 3,750 | 39,000 | 7,905 | Jul 03, 2013, 09:34 PM |
| Shapiro David | CMO & EVP - Development | Jul 02, 2013 | Sale | $43.63 | 4,369 | 190,623 | 3,536 | Jul 03, 2013, 09:34 PM |
| Pruzanski Mark | President and CEO | Jun 26, 2013 | Option Exercise | $9.82 | 12,300 | 120,814 | 414,332 | Jun 27, 2013, 09:30 PM |
| Pruzanski Mark | President and CEO | Jun 25, 2013 | Option Exercise | $9.82 | 200 | 1,964 | 402,232 | Jun 27, 2013, 09:30 PM |
| Pruzanski Mark | President and CEO | Jun 25, 2013 | Sale | $40.00 | 200 | 8,000 | 402,032 | Jun 27, 2013, 09:30 PM |
| Pruzanski Mark | President and CEO | Jun 26, 2013 | Sale | $40.06 | 12,300 | 492,745 | 402,032 | Jun 27, 2013, 09:30 PM |
| Adorini Luciano | Chief Scientific Officer | Jun 20, 2013 | Option Exercise | $10.40 | 2,000 | 20,800 | 6,445 | Jun 24, 2013, 09:30 PM |
| Adorini Luciano | Chief Scientific Officer | Jun 20, 2013 | Sale | $37.07 | 2,000 | 74,136 | 6,045 | Jun 24, 2013, 09:30 PM |
| Pruzanski Mark | President and CEO | Jun 20, 2013 | Option Exercise | $9.82 | 16,000 | 157,157 | 418,032 | Jun 21, 2013, 09:31 PM |
| Pruzanski Mark | President and CEO | Jun 19, 2013 | Option Exercise | $9.82 | 9,000 | 88,401 | 411,032 | Jun 21, 2013, 09:31 PM |
| Pruzanski Mark | President and CEO | Jun 19, 2013 | Sale | $38.08 | 9,000 | 342,751 | 402,032 | Jun 21, 2013, 09:31 PM |
| Pruzanski Mark | President and CEO | Jun 20, 2013 | Sale | $38.35 | 16,000 | 613,597 | 402,032 | Jun 21, 2013, 09:31 PM |
| Duncan Barbara Gayle | Chief Financial Officer | Jun 19, 2013 | Option Exercise | $9.63 | 50,575 | 486,874 | 56,759 | Jun 21, 2013, 09:30 PM |
| Duncan Barbara Gayle | Chief Financial Officer | Jun 19, 2013 | Sale | $34.50 | 50,575 | 1,744,838 | 6,814 | Jun 21, 2013, 09:30 PM |
| Shapiro David | CMO & EVP - Development | Jun 17, 2013 | Option Exercise | $10.40 | 3,750 | 39,000 | 7,548 | Jun 19, 2013, 09:31 PM |
| Shapiro David | CMO & EVP - Development | Jun 17, 2013 | Sale | $32.72 | 5,016 | 164,124 | 6,548 | Jun 19, 2013, 09:31 PM |
| Duncan Barbara Gayle | Chief Financial Officer | May 28, 2013 | Option Exercise | $8.67 | 4,915 | 42,597 | 11,729 | May 28, 2013, 09:30 PM |
| Duncan Barbara Gayle | Chief Financial Officer | May 24, 2013 | Option Exercise | $8.67 | 1,200 | 10,400 | 8,014 | May 28, 2013, 09:30 PM |
| Duncan Barbara Gayle | Chief Financial Officer | May 23, 2013 | Option Exercise | $8.67 | 110 | 953 | 6,924 | May 28, 2013, 09:30 PM |
| Duncan Barbara Gayle | Chief Financial Officer | May 28, 2013 | Sale | $34.50 | 4,915 | 169,568 | 6,814 | May 28, 2013, 09:30 PM |
| Duncan Barbara Gayle | Chief Financial Officer | May 24, 2013 | Sale | $34.50 | 1,200 | 41,400 | 6,814 | May 28, 2013, 09:30 PM |
| Duncan Barbara Gayle | Chief Financial Officer | May 23, 2013 | Sale | $34.54 | 110 | 3,799 | 6,814 | May 28, 2013, 09:30 PM |
| Duncan Barbara Gayle | Chief Financial Officer | May 20, 2013 | Option Exercise | $10.64 | 28,200 | 299,931 | 35,014 | May 22, 2013, 09:30 PM |
| Duncan Barbara Gayle | Chief Financial Officer | May 20, 2013 | Sale | $34.50 | 28,200 | 972,900 | 7,014 | May 22, 2013, 09:30 PM |
| Shapiro David | CMO and EVP - Development | May 16, 2013 | Option Exercise | $10.40 | 496 | 5,158 | 5,560 | May 20, 2013, 06:06 AM |
| Shapiro David | CMO and EVP - Development | May 15, 2013 | Option Exercise | $10.40 | 3,254 | 33,842 | 8,318 | May 20, 2013, 06:06 AM |
| Shapiro David | CMO and EVP - Development | May 16, 2013 | Sale | $31.22 | 1,762 | 55,012 | 5,095 | May 20, 2013, 06:06 AM |
| Shapiro David | CMO and EVP - Development | May 15, 2013 | Sale | $31.35 | 3,254 | 102,014 | 8,302 | May 20, 2013, 06:06 AM |
| Duncan Barbara Gayle | Chief Financial Officer | Apr 09, 2013 | Option Exercise | $34.57 | 2,676 | 92,509 | 3,814 | Apr 11, 2013, 09:36 PM |
| Shapiro David | CMO and EVP - Development | Apr 09, 2013 | Option Exercise | $34.57 | 3,049 | 105,404 | 5,064 | Apr 11, 2013, 09:34 PM |
| Shapiro David | CMO and EVP - Development | Apr 09, 2013 | Option Exercise | $10.40 | 3,750 | 39,000 | 3,750 | Apr 11, 2013, 09:34 PM |
| Shapiro David | CMO and EVP - Development | Apr 09, 2013 | Sale | $34.41 | 3,750 | 129,053 | 3,700 | Apr 11, 2013, 09:34 PM |
| Pruzanski Mark | President and CEO | Apr 09, 2013 | Option Exercise | $34.57 | 10,774 | 372,457 | 394,332 | Apr 11, 2013, 09:33 PM |
| ORBIMED ADVISORS LLC | 10% Owner | Oct 16, 2012 | Buy | $15.00 | 333,334 | 5,000,010 | 2,150,634 | Oct 16, 2012, 06:07 PM |
| AKKARAJU SRINIVAS | Director | Oct 16, 2012 | Buy | $15.00 | 700,000 | 10,500,000 | 700,000 | Oct 16, 2012, 06:03 PM |
| SILVERSTEIN JONATHAN | Director | Oct 16, 2012 | Buy | $15.00 | 333,334 | 5,000,010 | 2,150,634 | Oct 16, 2012, 06:02 PM |
Load More Insider Transactions
Buy
Sale
Option Exercise
| Owner | Relationship | Date | Value($) |
| Freedberg Jared | General Counsel | 05/01/2023 | 13,161 |
| Saik Andrew | EVP & Chief Financial Officer | 03/21/2023 | 12,899 |
| Berrey M Michelle | President, R&D & CMO | 03/14/2023 | 19,674 |
| Richardson Linda M | EVP & Chief Commercial Officer | 02/14/2023 | 8,187 |
| Freedberg Jared | General Counsel | 02/01/2023 | 17,222 |
| Venezia Rocco | Chief Accounting Officer | 12/31/2022 | 8,350 |
| Saik Andrew | EVP & Chief Financial Officer | 12/31/2022 | 8,882 |
| Richardson Linda M | EVP & Chief Commercial Officer | 12/31/2022 | 19,792 |
| Freedberg Jared | General Counsel | 12/31/2022 | 8,882 |
| Ford David A | Chief Human Resources Officer | 12/31/2022 | 21,981 |
| Durso Jerome Benedict | President & CEO | 12/31/2022 | 87,617 |
| Berrey M Michelle | President, R&D & CMO | 12/31/2022 | 9,463 |
| Saik Andrew | EVP & Chief Financial Officer | 12/21/2022 | 12,194 |
| Berrey M Michelle | President, R&D and CMO | 12/14/2022 | 18,615 |
| Freedberg Jared | General Counsel | 11/01/2022 | 12,128 |
| Saik Andrew | EVP & Chief Financial Officer | 09/21/2022 | 13,484 |
| Berrey M Michelle | President, R&D and CMO | 09/14/2022 | 21,356 |
| Venezia Rocco | Chief Accounting Officer | 09/01/2022 | 7,748 |
| Richardson Linda M | EVP & Chief Commercial Officer | 09/01/2022 | 10,782 |
| Richardson Linda M | EVP & Chief Commercial Officer | 08/15/2022 | 2,256 |
| Freedberg Jared | General Counsel | 08/01/2022 | 9,414 |
| BALL BRYAN | Chief Qual. Officer & SVP Ops. | 07/11/2022 | 6,353 |
| Saik Andrew | EVP & Chief Financial Officer | 06/21/2022 | 45,327 |
| Berrey M Michelle | President, R&D and CMO | 06/14/2022 | 60,306 |
| Richardson Linda M | EVP & Chief Commercial Officer | 05/15/2022 | 2,217 |
| Freedberg Jared | General Counsel | 05/01/2022 | 12,112 |
| BALL BRYAN | Chief Qual. Officer & SVP Ops. | 04/11/2022 | 9,128 |
| Richardson Linda M | EVP & Chief Commercial Officer | 02/15/2022 | 2,724 |
| Richardson Linda M | EVP & Chief Commercial Officer | 02/14/2022 | 7,856 |
| Cawkwell Gail | SVP, Med Affairs, Safety & PV | 02/12/2022 | 5,056 |
| Freedberg Jared | General Counsel | 02/01/2022 | 68,858 |
| BALL BRYAN | Chief Qual. Officer & SVP Ops. | 01/11/2022 | 41,318 |
| Cawkwell Gail | SVP, Med Affairs, Safety & PV | 12/31/2021 | 39,992 |
| Pruzanski Mark | Director | 11/30/2021 | 105,635 |
| Pruzanski Mark | Director | 11/30/2021 | 65,691 |
| Richardson Linda M | EVP & Chief Commercial Officer | 11/15/2021 | 3,022 |
| Cawkwell Gail | SVP, Med Affairs, Safety & PV | 11/12/2021 | 6,074 |
| Pruzanski Mark | Director | 10/29/2021 | 103,487 |
| Pruzanski Mark | Director | 10/29/2021 | 64,355 |
| Venezia Rocco | Chief Accounting Officer | 10/01/2021 | 457 |
| Ford David A | Chief Human Resources Officer | 10/01/2021 | 1,400 |
| Durso Jerome Benedict | President & CEO | 10/01/2021 | 4,399 |
| DeFrancesco Lisa | SVP, IR & Corp. Affairs | 09/30/2021 | 3,029 |
| Pruzanski Mark | Director | 09/30/2021 | 91,120 |
| Pruzanski Mark | Director | 09/30/2021 | 56,668 |
| Venezia Rocco | Chief Accounting Officer | 09/01/2021 | 7,886 |
| Richardson Linda M | EVP & Chief Commercial Officer | 09/01/2021 | 12,341 |
| DeFrancesco Lisa | SVP, IR & Corp. Affairs | 09/01/2021 | 8,097 |
| Pruzanski Mark | Director | 08/31/2021 | 91,518 |
| Pruzanski Mark | Director | 08/31/2021 | 56,911 |
| Richardson Linda M | EVP & Chief Commercial Officer | 08/15/2021 | 2,551 |
| Cawkwell Gail | SVP, Med Affairs, Safety & PV | 08/12/2021 | 4,874 |
| Pruzanski Mark | Director | 07/30/2021 | 106,065 |
| Pruzanski Mark | Director | 07/30/2021 | 65,958 |
| Venezia Rocco | Chief Accounting Officer | 07/01/2021 | 614 |
| Ford David A | Chief Human Resources Officer | 07/01/2021 | 1,883 |
| Durso Jerome Benedict | President & CEO | 07/01/2021 | 5,916 |
| Pruzanski Mark | Director | 06/30/2021 | 122,536 |
| Pruzanski Mark | Director | 06/30/2021 | 76,206 |
| Pruzanski Mark | Director | 05/28/2021 | 102,075 |
| Pruzanski Mark | Director | 05/28/2021 | 63,477 |
| Richardson Linda M | EVP & Chief Commercial Officer | 05/15/2021 | 3,104 |
| Cawkwell Gail | SVP, Med Affairs, Safety & PV | 05/12/2021 | 5,662 |
| Ford David A | Chief Human Resources Officer | 05/08/2021 | 2,195 |
| Pruzanski Mark | Director | 04/30/2021 | 121,410 |
| Pruzanski Mark | Director | 04/30/2021 | 75,500 |
| Weyer Christian | EVP, Research & Development | 04/01/2021 | 1,117 |
| Venezia Rocco | Chief Accounting Officer | 04/01/2021 | 704 |
| Ford David A | Chief Human Resources Officer | 04/01/2021 | 2,234 |
| Durso Jerome Benedict | President & CEO | 04/01/2021 | 7,017 |
| Pruzanski Mark | Director | 03/31/2021 | 141,619 |
| Pruzanski Mark | Director | 03/31/2021 | 84,427 |
| AKKARAJU SRINIVAS | Director | 03/12/2021 | 3,129,630 |
| AKKARAJU SRINIVAS | Director | 03/10/2021 | 1,886,622 |
| Pruzanski Mark | Director | 02/26/2021 | 132,949 |
| Pruzanski Mark | Director | 02/26/2021 | 59,370 |
| Weyer Christian | EVP, Research & Development | 02/27/2021 | 7,733 |
| Durso Jerome Benedict | President & CEO | 02/23/2021 | 8,970 |
| Cawkwell Gail | SVP, Med Affairs, Safety & PV | 02/12/2021 | 9,991 |
| Ford David A | Chief Human Resources Officer | 02/08/2021 | 5,334 |
| Pruzanski Mark | Director | 01/29/2021 | 216,303 |
| Pruzanski Mark | Director | 01/29/2021 | 96,593 |
| Weyer Christian | EVP, Research & Development | 01/01/2021 | 1,334 |
| Weyer Christian | EVP, Research & Development | 12/31/2020 | 19,241 |
| Pruzanski Mark | Director | 12/31/2020 | 1,018,529 |
| Pruzanski Mark | Director | 12/31/2020 | 619,106 |
| Pruzanski Mark | Director | 01/01/2021 | 15,610 |
| Kim Richard J | President US Comm & Strat Mktg | 01/01/2021 | 6,397 |
| Kim Richard J | President US Comm & Strat Mktg | 12/31/2020 | 19,735 |
| Kapadia Sandip | CFO and Treasurer | 01/01/2021 | 8,447 |
| Kapadia Sandip | CFO and Treasurer | 12/31/2020 | 21,217 |
| Kapadia Sandip | CFO and Treasurer | 01/05/2021 | 53,663 |
| Ford David A | Chief Human Resources Officer | 01/01/2021 | 2,618 |
| Ford David A | Chief Human Resources Officer | 12/31/2020 | 15,536 |
| Campagna Jason | Chief Medical Officer | 01/01/2021 | 3,260 |
| Campagna Jason | Chief Medical Officer | 12/31/2020 | 13,190 |
| Durso Jerome Benedict | President & CEO | 01/01/2021 | 8,250 |
| Durso Jerome Benedict | President & CEO | 12/31/2020 | 41,990 |
| Cawkwell Gail | SVP, Med Affairs, Safety & PV | 12/31/2020 | 17,438 |
| Kapadia Sandip | CFO and Treasurer | 12/15/2020 | 57,791 |
| Weyer Christian | EVP, Research & Development | 11/27/2020 | 13,305 |
| Durso Jerome Benedict | Chief Operating Officer | 11/23/2020 | 11,315 |
| Sullivan Ryan T | General Counsel and Secretary | 11/13/2020 | 18,670 |
| Cawkwell Gail | SVP, Med Affairs, Safety & PV | 11/12/2020 | 12,288 |
| Ford David A | Chief Human Resources Officer | 11/08/2020 | 3,603 |
| Campagna Jason | Chief Medical Officer | 10/01/2020 | 4,713 |
| Durso Jerome Benedict | Chief Operating Officer | 10/01/2020 | 12,161 |
| Weyer Christian | EVP, Research & Development | 10/01/2020 | 1,936 |
| Pruzanski Mark | President & CEO | 10/01/2020 | 32,486 |
| Kim Richard J | President US Comm & Strat Mktg | 10/01/2020 | 9,384 |
| Kapadia Sandip | CFO and Treasurer | 10/01/2020 | 12,456 |
| Ford David A | Chief Human Resources Officer | 10/01/2020 | 3,871 |
| Campagna Jason | Chief Medical Officer | 09/15/2020 | 2,995 |
| Weyer Christian | EVP, Research & Development | 08/27/2020 | 17,425 |
| Durso Jerome Benedict | Chief Operating Officer | 08/23/2020 | 15,379 |
| Campagna Jason | Chief Medical Officer | 08/18/2020 | 56,543 |
| Genextra S.p.A. | 10% Owner | 08/17/2020 | 64,123,099 |
| Genextra S.p.A. | 10% Owner | 08/14/2020 | 2,760,112 |
| Genextra S.p.A. | 10% Owner | 08/13/2020 | 4,365,451 |
| Micheli Francesco | 10% Owner | 08/13/2020 | 4,365,451 |
| Micheli Francesco | 10% Owner | 08/17/2020 | 64,123,099 |
| Micheli Francesco | 10% Owner | 08/14/2020 | 2,760,112 |
| Fundaro Paolo | Director | 08/17/2020 | 64,123,099 |
| Fundaro Paolo | Director | 08/14/2020 | 2,760,112 |
| Fundaro Paolo | Director | 08/13/2020 | 4,365,451 |
| Sullivan Ryan T | General Counsel and Secretary | 08/13/2020 | 25,567 |
| Cawkwell Gail | SVP, Med Affairs, Safety & PV | 08/12/2020 | 17,047 |
| Ford David A | Chief Human Resources Officer | 08/08/2020 | 6,240 |
| Weyer Christian | EVP, Research & Development | 07/01/2020 | 2,140 |
| Pruzanski Mark | President & CEO | 07/01/2020 | 35,913 |
| Kim Richard J | President US Comm & Strat Mktg | 07/01/2020 | 10,420 |
| Kapadia Sandip | CFO and Treasurer | 07/01/2020 | 28,610 |
| Ford David A | Chief Human Resources Officer | 07/01/2020 | 4,280 |
| Campagna Jason | Chief Medical Officer | 07/01/2020 | 5,210 |
| Bright Lisa | President, International | 07/01/2020 | 14,003 |
| Durso Jerome Benedict | Chief Operating Officer | 07/01/2020 | 13,444 |
| Campagna Jason | Chief Medical Officer | 06/15/2020 | 5,418 |
| Weyer Christian | EVP, Research & Development | 05/27/2020 | 26,572 |
| Durso Jerome Benedict | Chief Operating Officer | 05/23/2020 | 25,683 |
| Fundaro Paolo | Director | 05/13/2020 | 50,385,898 |
| Micheli Francesco | 10% Owner | 05/13/2020 | 50,385,898 |
| Genextra S.p.A. | 10% Owner | 05/13/2020 | 50,385,898 |
| Sullivan Ryan T | General Counsel and Secretary | 05/13/2020 | 41,944 |
| Cawkwell Gail | SVP, Med Affairs, Safety & PV | 05/12/2020 | 28,407 |
| Ford David A | Chief Human Resources Officer | 05/08/2020 | 11,238 |
| Weyer Christian | EVP, Research & Development | 04/27/2020 | 15,557 |
| Ford David A | Chief Human Resources Officer | 04/09/2020 | 4,060 |
| Weyer Christian | EVP, Research & Development | 04/01/2020 | 2,686 |
| Pruzanski Mark | President & CEO | 04/01/2020 | 33,171 |
| Kim Richard J | President US Comm & Strat Mktg | 04/01/2020 | 13,023 |
| Kapadia Sandip | CFO and Treasurer | 04/01/2020 | 35,916 |
| Ford David A | Chief Human Resources Officer | 04/01/2020 | 5,373 |
| Durso Jerome Benedict | Chief Operating Officer | 04/01/2020 | 16,878 |
| Campagna Jason | Chief Medical Officer | 04/01/2020 | 6,541 |
| Bright Lisa | President, International | 04/01/2020 | 17,578 |
| Campagna Jason | Chief Medical Officer | 03/15/2020 | 4,956 |
| Weyer Christian | EVP, Research & Development | 02/27/2020 | 30,484 |
| Weyer Christian | EVP, Research & Development | 02/27/2020 | 9,901 |
| Durso Jerome Benedict | Chief Operating Officer | 02/23/2020 | 30,302 |
| Campagna Jason | Chief Medical Officer | 02/19/2020 | 16,361 |
| Sullivan Ryan T | General Counsel and Secretary | 02/13/2020 | 46,682 |
| Cawkwell Gail | SVP, Med Affairs, Safety & PV | 02/12/2020 | 30,860 |
| Ford David A | Chief Human Resources Officer | 02/08/2020 | 14,085 |
| Weyer Christian | EVP, Research & Development | 01/27/2020 | 67,991 |
| Campagna Jason | Chief Medical Officer | 01/07/2020 | 82,731 |
| Durso Jerome Benedict | Chief Operating Officer | 01/01/2020 | 41,389 |
| Durso Jerome Benedict | Chief Operating Officer | 12/31/2019 | 142,632 |
| Campagna Jason | Chief Medical Officer | 12/31/2019 | 32,095 |
| Bright Lisa | President, International | 12/31/2019 | 48,081 |
| Kapadia Sandip | CFO and Treasurer | 01/01/2020 | 82,902 |
| Pruzanski Mark | President & CEO | 01/01/2020 | 144,491 |
| Kapadia Sandip | CFO and Treasurer | 12/31/2019 | 68,280 |
| Pruzanski Mark | President & CEO | 12/31/2019 | 140,154 |
| Kim Richard J | President US Comm & Strat Mktg | 01/01/2020 | 38,291 |
| Kim Richard J | President US Comm & Strat Mktg | 12/31/2019 | 42,133 |
| Campagna Jason | Chief Medical Officer | 01/01/2020 | 18,588 |
| Bright Lisa | President, International | 01/01/2020 | 65,678 |
| Pruzanski Mark | President & CEO | 12/31/2019 | 2,150 |
| Pruzanski Mark | President & CEO | 12/31/2019 | 12,500 |
| Weyer Christian | EVP, Research & Development | 12/31/2019 | 45,107 |
| Sullivan Ryan T | General Counsel and Secretary | 12/31/2019 | 100,251 |
| Ford David A | Chief Human Resources Officer | 01/01/2020 | 13,136 |
| Ford David A | Chief Human Resources Officer | 12/31/2019 | 40,026 |
| Cawkwell Gail | SVP, Med Affairs, Safety & PV | 12/31/2019 | 43,248 |
| Weyer Christian | EVP, Research & Development | 01/01/2020 | 6,692 |
| Cawkwell Gail | SVP, Med Affairs, Safety & PV | 12/31/2019 | 14,313 |
| Ford David A | Chief Human Resources Officer | 01/03/2019 | 30,344 |
| Cawkwell Gail | SVP, Med Affairs, Safety & PV | 12/31/2019 | 32,750 |
| Weyer Christian | EVP, Research & Development | 12/27/2019 | 27,766 |
| Weyer Christian | EVP, Research & Development | 12/27/2019 | 194,842 |
| Pruzanski Mark | President & CEO | 12/26/2019 | 8,966 |
| Pruzanski Mark | President & CEO | 12/26/2019 | 52,125 |
| Cawkwell Gail | SVP, Med Affairs, Safety & PV | 12/26/2019 | 2,950 |
| Cawkwell Gail | SVP, Med Affairs, Safety & PV | 12/26/2019 | 6,750 |
| Campagna Jason | Chief Medical Officer | 12/19/2019 | 18,395 |
| Campagna Jason | Chief Medical Officer | 12/15/2019 | 9,133 |
| Cawkwell Gail | SVP, Med Affairs, Safety & PV | 12/03/2019 | 4,370 |
| Weyer Christian | EVP, Research & Development | 11/27/2019 | 38,970 |
| Weyer Christian | EVP, Research & Development | 11/27/2019 | 54,784 |
| Weyer Christian | EVP, Research & Development | 11/27/2019 | 105,716 |
| Weyer Christian | EVP, Research & Development | 11/26/2019 | 258,491 |
| Weyer Christian | EVP, Research & Development | 11/25/2019 | 109,628 |
| Weyer Christian | EVP, Research & Development | 11/25/2019 | 185,500 |
| Weyer Christian | EVP, Research & Development | 11/26/2019 | 437,300 |
| Pruzanski Mark | President & CEO | 11/26/2019 | 506,770 |
| Pruzanski Mark | President & CEO | 11/25/2019 | 126,213 |
| Pruzanski Mark | President & CEO | 11/26/2019 | 3,543,700 |
| Pruzanski Mark | President & CEO | 11/25/2019 | 1,456,300 |
| Durso Jerome Benedict | Chief Operating Officer | 11/23/2019 | 40,889 |
| Weyer Christian | EVP, Research & Development | 11/19/2019 | 131,750 |
| Sullivan Ryan T | General Counsel and Secretary | 11/19/2019 | 444,638 |
| Sullivan Ryan T | General Counsel and Secretary | 11/19/2019 | 1,033,090 |
| Sullivan Ryan T | General Counsel and Secretary | 11/13/2019 | 59,667 |
| Sullivan Ryan T | General Counsel and Secretary | 11/13/2019 | 26,705 |
| Sullivan Ryan T | General Counsel and Secretary | 11/13/2019 | 42,500 |
| Weyer Christian | EVP, Research & Development | 11/13/2019 | 80,410 |
| Cawkwell Gail | SVP, Med Affairs, Safety & PV | 11/12/2019 | 26,483 |
| Ford David A | Chief Human Resources Officer | 11/08/2019 | 10,593 |
| Bright Lisa | President, International | 10/29/2019 | 44,625 |
| Ford David A | Chief Human Resources Officer | 10/23/2019 | 4,060 |
| Ford David A | Chief Human Resources Officer | 10/01/2019 | 6,060 |
| Durso Jerome Benedict | Chief Operating Officer | 10/01/2019 | 27,468 |
| Bright Lisa | President, International | 10/01/2019 | 34,911 |
| Weyer Christian | EVP, Research & Development | 10/01/2019 | 3,030 |
| Pruzanski Mark | President & CEO | 10/01/2019 | 101,901 |
| Kim Richard J | President US Comm & Strat Mktg | 10/01/2019 | 17,587 |
| Kapadia Sandip | CFO and Treasurer | 10/01/2019 | 41,235 |
| Ford David A | Chief Human Resources Officer | 09/16/2019 | 56,000 |
| AKKARAJU SRINIVAS | Director | 08/28/2019 | 314,086 |
| Weyer Christian | EVP, Research & Development | 08/27/2019 | 21,599 |
| Durso Jerome Benedict | Chief Operating Officer | 08/23/2019 | 19,427 |
| AKKARAJU SRINIVAS | Director | 08/22/2019 | 75,874 |
| AKKARAJU SRINIVAS | Director | 08/21/2019 | 1,946,480 |
| AKKARAJU SRINIVAS | Director | 08/20/2019 | 2,476,223 |
| AKKARAJU SRINIVAS | Director | 08/22/2019 | 75,874 |
| AKKARAJU SRINIVAS | Director | 08/21/2019 | 1,946,480 |
| AKKARAJU SRINIVAS | Director | 08/20/2019 | 2,476,223 |
| Sullivan Ryan T | General Counsel and Secretary | 08/13/2019 | 45,495 |
| Cawkwell Gail | SVP, Med Affairs, Safety & PV | 08/12/2019 | 21,019 |
| Ford David A | Chief Human Resources Officer | 08/08/2019 | 8,454 |
| Kim Richard J | President US Comm & Strat Mktg | 07/13/2019 | 7,738 |
| Weyer Christian | EVP, Research & Development | 07/01/2019 | 3,642 |
| Kapadia Sandip | CFO and Treasurer | 07/01/2019 | 48,690 |
| Durso Jerome Benedict | Chief Operating Officer | 07/01/2019 | 22,880 |
| Kim Richard J | President US Comm & Strat Mktg | 07/01/2019 | 21,218 |
| Ford David A | Chief Human Resources Officer | 07/01/2019 | 7,284 |
| Pruzanski Mark | President & CEO | 07/01/2019 | 122,555 |
| Bright Lisa | President, International | 07/01/2019 | 41,960 |
| Bright Lisa | President, International | 07/03/2019 | 46,803 |
| Weyer Christian | EVP, Research & Development | 05/27/2019 | 31,355 |
| Durso Jerome Benedict | Chief Operating Officer | 05/23/2019 | 39,335 |
| Fundaro Paolo | Director | 05/20/2019 | 102,887 |
| AKKARAJU SRINIVAS | Director | 05/14/2019 | 9,999,960 |
| Sullivan Ryan T | General Counsel and Secretary | 05/13/2019 | 59,532 |
| Cawkwell Gail | SVP, Med Affairs, Safety & PV | 05/12/2019 | 27,645 |
| Benatti Luca | Director | 05/14/2019 | 100,200 |
| Ford David A | Chief Human Resources Officer | 05/08/2019 | 11,209 |
| Shapiro David | Chief Medical Officer | 05/01/2019 | 63,800 |
| Shapiro David | Chief Medical Officer | 05/01/2019 | 172,560 |
| AKKARAJU SRINIVAS | Director | 04/25/2019 | 85,660 |
| Cawkwell Gail | SVP, Med Affairs, Safety & PV | 04/18/2019 | 95,603 |
| Shapiro David | Chief Medical Officer | 04/15/2019 | 63,800 |
| Shapiro David | Chief Medical Officer | 04/15/2019 | 190,000 |
| Kim Richard J | President US Comm & Strat Mktg | 04/13/2019 | 7,331 |
| Weyer Christian | EVP, Research & Development | 04/01/2019 | 5,129 |
| Bright Lisa | President, International | 04/01/2019 | 59,207 |
| Durso Jerome Benedict | Chief Operating Officer | 04/01/2019 | 32,224 |
| Bright Lisa | President, International | 04/03/2019 | 68,316 |
| Ford David A | Chief Human Resources Officer | 04/01/2019 | 10,258 |
| Pruzanski Mark | President & CEO | 04/01/2019 | 172,491 |
| Shapiro David | Chief Medical Officer | 04/01/2019 | 53,743 |
| Kapadia Sandip | CFO and Treasurer | 04/01/2019 | 68,573 |
| Kim Richard J | President US Comm & Strat Mktg | 04/01/2019 | 29,771 |
| Shapiro David | Chief Medical Officer | 04/03/2019 | 64,636 |
| Fundaro Paolo | Director | 03/29/2019 | 233,272 |
| Weyer Christian | EVP, Research & Development | 02/27/2019 | 33,765 |
| Weyer Christian | EVP, Research & Development | 03/01/2019 | 34,352 |
| Shapiro David | Chief Medical Officer | 03/01/2019 | 63,800 |
| Shapiro David | Chief Medical Officer | 03/01/2019 | 206,320 |
| Durso Jerome Benedict | Chief Operating Officer | 02/23/2019 | 29,779 |
| AKKARAJU SRINIVAS | Director | 02/19/2019 | 3,018,346 |
| Shapiro David | Chief Medical Officer | 02/15/2019 | 63,800 |
| Shapiro David | Chief Medical Officer | 02/15/2019 | 223,020 |
| Sullivan Ryan T | General Counsel and Secretary | 02/13/2019 | 217,500 |
| Cawkwell Gail | SVP, Med Affairs, Safety & PV | 02/12/2019 | 141,700 |
| Ford David A | Chief Human Resources Officer | 02/08/2019 | 14,863 |
| Kim Richard J | President US Comm & Strat Mktg | 01/13/2019 | 8,449 |
| Bright Lisa | President, International | 01/07/2019 | 137,773 |
| Shapiro David | Chief Medical Officer | 01/04/2019 | 46,206 |
| Weyer Christian | EVP, Research & Development | 01/01/2019 | 21,670 |
| Shapiro David | Chief Medical Officer | 01/01/2019 | 74,181 |
| Shapiro David | Chief Medical Officer | 01/02/2019 | 63,800 |
| Shapiro David | Chief Medical Officer | 01/03/2019 | 68,118 |
| Shapiro David | Chief Medical Officer | 01/02/2019 | 196,560 |
| Pruzanski Mark | President & CEO | 01/01/2019 | 154,914 |
| Kim Richard J | President US Comm & Strat Mktg | 01/01/2019 | 70,755 |
| Kapadia Sandip | CFO and Treasurer | 01/01/2019 | 112,683 |
| Ford David A | Chief Human Resources Officer | 01/01/2019 | 42,634 |
| Durso Jerome Benedict | Chief Operating Officer | 01/01/2019 | 122,863 |
| Bright Lisa | President, International | 01/01/2019 | 117,723 |
| Shapiro David | Chief Medical Officer | 12/17/2018 | 63,800 |
| Shapiro David | Chief Medical Officer | 12/17/2018 | 213,240 |
| Bright Lisa | President, International | 12/04/2018 | 33,300 |
| Bright Lisa | President, International | 12/03/2018 | 523,820 |
| Micheli Francesco | 10% Owner | 11/29/2018 | 78,802,500 |
| Genextra S.p.A. | 10% Owner | 11/29/2018 | 78,802,500 |
| Weyer Christian | EVP, Research & Development | 11/27/2018 | 156,253 |
| Weyer Christian | EVP, Research & Development | 11/29/2018 | 152,807 |
| Durso Jerome Benedict | Chief Operating Officer | 11/23/2018 | 51,092 |
| Bright Lisa | President, International | 11/24/2018 | 27,434 |
| Pruzanski Mark | President & CEO | 11/16/2018 | 239,253 |
| Pruzanski Mark | President & CEO | 11/15/2018 | 194,082 |
| Pruzanski Mark | President & CEO | 11/16/2018 | 2,803,132 |
| Pruzanski Mark | President & CEO | 11/15/2018 | 2,250,580 |
| Ford David A | Chief Human Resources Officer | 11/08/2018 | 14,565 |
| Shapiro David | Chief Medical Officer | 11/01/2018 | 43,000 |
| Shapiro David | Chief Medical Officer | 11/01/2018 | 192,640 |
| Kim Richard J | President US Comm & Strat Mktg | 10/13/2018 | 7,987 |
| Shapiro David | Chief Medical Officer | 10/15/2018 | 73,638 |
| Shapiro David | Chief Medical Officer | 10/15/2018 | 352,604 |
| Shapiro David | Chief Medical Officer | 10/05/2018 | 83,983 |
| Shapiro David | Chief Medical Officer | 10/01/2018 | 53,872 |
| Shapiro David | Chief Medical Officer | 07/01/2018 | 34,907 |
| Shapiro David | Chief Medical Officer | 04/01/2018 | 26,023 |
| Shapiro David | Chief Medical Officer | 01/01/2018 | 59,588 |
| Kim Richard J | President US Comm & Strat Mktg | 07/13/2018 | 7,477 |
| Kim Richard J | President US Comm & Strat Mktg | 10/13/2017 | 5,501 |
| Kim Richard J | President US Comm & Strat Mktg | 07/01/2018 | 12,083 |
| Kim Richard J | President US Comm & Strat Mktg | 04/13/2018 | 5,626 |
| Kim Richard J | President US Comm & Strat Mktg | 04/01/2018 | 8,859 |
| Kim Richard J | President US Comm & Strat Mktg | 02/10/2018 | 59,685 |
| Kim Richard J | President US Comm & Strat Mktg | 01/13/2018 | 4,891 |
| Kim Richard J | President US Comm & Strat Mktg | 01/01/2018 | 32,248 |
| Kim Richard J | President US Comm & Strat Mktg | 10/01/2018 | 18,210 |
| Bright Lisa | President, International | 04/01/2018 | 32,113 |
| Bright Lisa | President, International | 02/24/2018 | 15,324 |
| Bright Lisa | President, International | 10/01/2018 | 65,886 |
| Bright Lisa | President, International | 01/08/2018 | 22,215 |
| Bright Lisa | President, International | 08/24/2018 | 26,787 |
| Bright Lisa | President, International | 01/01/2018 | 54,623 |
| Bright Lisa | President, International | 07/01/2018 | 43,717 |
| Bright Lisa | President, International | 12/18/2017 | 25,701 |
| Bright Lisa | President, International | 05/31/2018 | 29,067 |
| Bright Lisa | President, International | 11/24/2017 | 15,610 |
| Bright Lisa | President, International | 05/24/2018 | 17,231 |
| Kapadia Sandip | CFO and Treasurer | 01/01/2018 | 64,671 |
| Kapadia Sandip | CFO and Treasurer | 10/01/2018 | 67,150 |
| Kapadia Sandip | CFO and Treasurer | 07/01/2018 | 39,270 |
| Kapadia Sandip | CFO and Treasurer | 04/01/2018 | 28,791 |
| Durso Jerome Benedict | Chief Operating Officer | 08/23/2018 | 34,334 |
| Durso Jerome Benedict | Chief Operating Officer | 05/23/2018 | 22,317 |
| Durso Jerome Benedict | Chief Operating Officer | 02/23/2018 | 81,769 |
| Ford David A | Chief Human Resources Officer | 05/08/2018 | 35,777 |
| Ford David A | Chief Human Resources Officer | 08/08/2018 | 14,956 |
| Pruzanski Mark | President & CEO | 10/01/2018 | 259,117 |
| Pruzanski Mark | President & CEO | 07/01/2018 | 172,099 |
| Pruzanski Mark | President & CEO | 04/01/2018 | 126,116 |
| Pruzanski Mark | President & CEO | 01/01/2018 | 210,838 |
| Shapiro David | Chief Medical Officer | 09/05/2018 | 547,891 |
| Gottesdiener Keith Michael | Director | 04/09/2018 | 74,944 |
| Pruzanski Mark | CEO & President | 04/09/2018 | 499,968 |
| BRADBURY DANIEL | Director | 04/09/2018 | 499,968 |
| Genextra S.p.A. | 10% Owner | 04/09/2018 | 25,000,000 |
| Micheli Francesco | 10% Owner | 04/09/2018 | 25,000,000 |
| AKKARAJU SRINIVAS | Director | 04/05/2018 | 15,000,000 |
| Kim Richard J | SVP, Commercial US | 10/02/2017 | 2,789 |
| Kapadia Sandip | Chief Financial Officer | 10/02/2017 | 20,827 |
| Bright Lisa | President International | 10/02/2017 | 22,980 |
| Shapiro David | CMO and EVP - Development | 10/02/2017 | 20,556 |
| Pruzanski Mark | CEO & President | 10/02/2017 | 90,189 |
| McMinn Rachel | Chief Strategy Officer | 10/02/2017 | 16,667 |
| Shapiro David | CMO and EVP - Development | 09/01/2017 | 39,875 |
| Shapiro David | CMO and EVP - Development | 09/01/2017 | 146,788 |
| Bright Lisa | President International | 08/25/2017 | 28,161 |
| Bright Lisa | President International | 08/02/2017 | 15,661 |
| Shapiro David | CMO and EVP - Development | 08/01/2017 | 9,689 |
| Shapiro David | CMO and EVP - Development | 08/01/2017 | 133,042 |
| WELCH DANIEL G | Director | 07/31/2017 | 74,603 |
| McMinn Rachel | Chief Strategy Officer | 07/31/2017 | 16,005 |
| WELCH DANIEL G | Director | 07/20/2017 | 27,507 |
| Kim Richard J | SVP, Commercial US | 07/14/2017 | 11,449 |
| Shapiro David | CMO and EVP - Development | 07/11/2017 | 68,578 |
| Kapadia Sandip | Chief Financial Officer | 07/03/2017 | 174,000 |
| Shapiro David | CMO and EVP - Development | 07/03/2017 | 42,435 |
| Pruzanski Mark | CEO & President | 07/03/2017 | 174,633 |
| McMinn Rachel | Chief Strategy Officer | 07/03/2017 | 31,297 |
| Bright Lisa | President International | 07/03/2017 | 47,802 |
| Kim Richard J | SVP, Commercial US | 07/03/2017 | 6,085 |
| Pruzanski Mark | CEO & President | 06/26/2017 | 346,668 |
| Pruzanski Mark | CEO & President | 06/26/2017 | 5,231,856 |
| Bright Lisa | President International | 06/01/2017 | 77,289 |
| Bright Lisa | President International | 05/25/2017 | 29,850 |
| Bright Lisa | President International | 05/16/2017 | 13,531 |
| Bright Lisa | President International | 05/02/2017 | 48,564 |
| Shapiro David | CMO and EVP - Development | 05/01/2017 | 9,681 |
| Shapiro David | CMO and EVP - Development | 05/01/2017 | 125,305 |
| McMinn Rachel | Chief Strategy Officer | 05/01/2017 | 12,896 |
| Shapiro David | CMO and EVP - Development | 04/10/2017 | 60,549 |
| McMinn Rachel | Chief Strategy Officer | 04/03/2017 | 29,554 |
| Bright Lisa | President International | 04/03/2017 | 44,734 |
| Shapiro David | CMO and EVP - Development | 04/03/2017 | 39,789 |
| Pruzanski Mark | CEO & President | 04/03/2017 | 115 |
| Bright Lisa | President International | 03/02/2017 | 170,904 |
| Shapiro David | CMO and EVP - Development | 03/01/2017 | 29,025 |
| Shapiro David | CMO and EVP - Development | 03/01/2017 | 173,691 |
| Bright Lisa | President International | 03/01/2017 | 17,702 |
| Bright Lisa | President International | 02/27/2017 | 30,348 |
| Bright Lisa | President International | 01/31/2017 | 14,601 |
| Shapiro David | CMO and EVP - Development | 01/09/2017 | 165,906 |
| Bright Lisa | President International | 01/03/2017 | 116,285 |
| Shapiro David | CMO and EVP - Development | 01/03/2017 | 102,672 |
| Pruzanski Mark | CEO & President | 01/03/2017 | 291,181 |
| McMinn Rachel | Chief Strategy Officer | 01/03/2017 | 84,798 |
| Pruzanski Mark | CEO & President | 12/06/2016 | 99,982 |
| Shapiro David | CMO and EVP - Development | 12/02/2016 | 134,663 |
| Bright Lisa | President International | 11/25/2016 | 28,286 |
| Bright Lisa | President International | 11/15/2016 | 15,718 |
| McMinn Rachel | Chief Strategy Officer | 10/31/2016 | 15,972 |
| Shapiro David | CMO and EVP - Development | 10/10/2016 | 63,023 |
| Pruzanski Mark | CEO & President | 10/03/2016 | 115,056 |
| Shapiro David | CMO and EVP - Development | 10/03/2016 | 29,025 |
| Shapiro David | CMO and EVP - Development | 10/03/2016 | 246,733 |
| Duncan Barbara Gayle | Chief Accounting Officer | 10/03/2016 | 23,990 |
| Bright Lisa | See Remarks | 10/03/2016 | 25,296 |
| Shapiro David | CMO and EVP - Development | 09/26/2016 | 585,199 |
| Pruzanski Mark | CEO & President | 09/20/2016 | 313,054 |
| Pruzanski Mark | CEO & President | 09/20/2016 | 5,775,000 |
| Bright Lisa | President of International | 08/25/2016 | 39,114 |
| McMinn Rachel | Chief Strategy Officer | 08/01/2016 | 22,071 |
| Pruzanski Mark | CEO & President | 07/15/2016 | 1,091,827 |
| Pruzanski Mark | CEO & President | 07/15/2016 | 122,779 |
| Duncan Barbara Gayle | Chief Accounting Officer | 07/05/2016 | 21,186 |
| Shapiro David | CMO and EVP - Development | 07/05/2016 | 23,653 |
| Pruzanski Mark | CEO & President | 07/05/2016 | 103,608 |
| McMinn Rachel | Chief Strategy Officer | 07/05/2016 | 15,382 |
| Bright Lisa | See Remarks | 07/05/2016 | 22,492 |
| Bright Lisa | See Remarks | 05/25/2016 | 34,512 |
| AKKARAJU SRINIVAS | Director | 05/13/2016 | 32,250 |
| McMinn Rachel | Chief Strategy Officer | 05/02/2016 | 19,174 |
| Shapiro David | CMO and EVP - Development | 04/04/2016 | 21,575 |
| Pruzanski Mark | CEO & President | 04/04/2016 | 92,578 |
| McMinn Rachel | Chief Strategy Officer | 04/04/2016 | 13,599 |
| Bright Lisa | See Remarks | 04/04/2016 | 20,006 |
| Duncan Barbara Gayle | Chief Financial Officer | 04/04/2016 | 18,829 |
| Bright Lisa | See Remarks | 02/25/2016 | 27,768 |
| McMinn Rachel | Chief Strategy Officer | 02/01/2016 | 13,256 |
| Bright Lisa | See Remarks | 01/13/2016 | 13,519 |
| Bright Lisa | See Remarks | 01/12/2016 | 77,862 |
| McMinn Rachel | Chief Strategy Officer | 01/04/2016 | 68,429 |
| Duncan Barbara Gayle | Chief Financial Officer | 01/04/2016 | 68,283 |
| Shapiro David | CMO and EVP - Development | 01/04/2016 | 77,767 |
| Pruzanski Mark | CEO & President | 01/04/2016 | 310,192 |
| Shapiro David | CMO and EVP - Development | 12/18/2015 | 199,991 |
| Shapiro David | CMO and EVP - Development | 12/15/2015 | 30,333 |
| Shapiro David | CMO and EVP - Development | 12/15/2015 | 550,900 |
| Bright Lisa | See Remarks | 11/25/2015 | 210,410 |
| WILLIAMS NICOLE | Director | 11/20/2015 | 9,557 |
| WILLIAMS NICOLE | Director | 11/20/2015 | 162,491 |
| Shapiro David | CMO and EVP - Development | 11/16/2015 | 30,333 |
| Shapiro David | CMO and EVP - Development | 11/16/2015 |