FibroGen Inc. (FGEN) NASDAQ
$1.25 0.06 (5.04%)
Market Cap: $118.37M
As of 05/16/24 03:59 PM EDT. Market closed.
FibroGen Inc. (FGEN)
NASDAQ
$1.25
0.06 (5.04%)
Market Cap: $118.37M
As of 05/16/24 03:59 PM EDT. Market closed.
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fibrogen is a research-based biopharmaceutical company focused on the discovery, development and commercialization of novel therapeutics to treat serious unmet medical needs. the company has built upon its extensive research experience in fibrosis and hypoxia-inducible factor (hif) biology to generate clinical programs targeting multiple therapeutic areas. fibrogen's most advanced product ... read more
COMPANY PROFILE
Sector
Professional, Scientific, and Technical Services
Industry
Research and Development in Biotechnology (except Nanobiotechnology)
CEO
Enrique Conterno
Full Time Employees
466
CEO Compensation (Base)
$875,000
CEO Compensation (Total)
$9.22M
Sector
Professional, Scientific, and Technical Services
Industry
Research and Development in Biotechnology (except Nanobiotechnology)
CEO
Enrique Conterno
Full Time Employees
466
CEO Compensation (Base)
$875,000
CEO Compensation (Total)
$9.22M
URL
Address
409 Illinois St, California, San Francisco, 94158-2509.
PRICE CHART FOR FIBROGEN INC
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NEWS
INSIDEARBITRAGE ARTICLES
KEY STATS
Open
$1.18
Previous Close
$1.19
Days Range
$1.16 - $1.26
52 week range
$0.33 - $19.47
Volume
1,660,552
Avg. Volume (30 days)
3,017,647
Market Cap
$118.37M
Dividend Yield
-
P/E
(0.49)
Shares Outstanding
99,474,398
Open
$1.18
Previous Close
$1.19
Days Range
$1.16 - $1.26
52 week range
$0.33 - $19.47
Volume
1,660,552
Avg. Volume (30 days)
3,017,647
Market Cap
$118.37M
Dividend Yield
-
P/E
(0.49)
Shares Outstanding
99,474,398
FINANCIAL STATEMENTS FOR FIBROGEN INC
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INSIDER TRANSACTIONS FOR FIBROGEN INC
| Owner | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| Wettig Thane | CEO | May 01, 2024 | Option Exercise | $1.17 | 20,840 | 24,383 | 448,556 | May 02, 2024, 07:46 PM |
| Wettig Thane | CEO | Mar 22, 2024 | Option Exercise | $2.58 | 782 | 2,018 | 469,396 | Mar 25, 2024, 05:58 PM |
| Wettig Thane | CEO | Mar 07, 2024 | Buy | $1.91 | 50,000 | 95,470 | 470,178 | Mar 11, 2024, 07:06 PM |
| Graham Juan | CHIEF FINANCIAL OFFICER | Mar 07, 2024 | Option Exercise | $1.79 | 1,181 | 2,114 | 203,469 | Mar 08, 2024, 07:19 PM |
| Graham Juan | CHIEF FINANCIAL OFFICER | Mar 06, 2024 | Option Exercise | $1.87 | 20,749 | 38,801 | 204,650 | Mar 08, 2024, 07:19 PM |
| Wettig Thane | CEO | Mar 06, 2024 | Option Exercise | $1.87 | 4,535 | 8,480 | 420,178 | Mar 08, 2024, 07:18 PM |
| Chung Christine | SVP, CHINA OPERATIONS | Mar 06, 2024 | Option Exercise | $1.87 | 23,590 | 44,113 | 341,028 | Mar 08, 2024, 07:17 PM |
| Wettig Thane | CEO | Feb 01, 2024 | Option Exercise | $2.37 | 23,490 | 55,671 | 257,932 | Feb 05, 2024, 08:08 PM |
| Wettig Thane | CEO | Dec 22, 2023 | Option Exercise | $0.76 | 819 | 622 | 281,422 | Dec 26, 2023, 07:28 PM |
| Graham Juan | Chief Financial Officer | Dec 06, 2023 | Option Exercise | $0.58 | 15,573 | 9,032 | 173,703 | Dec 11, 2023, 04:21 PM |
| Graham Juan | Chief Financial Officer | Dec 07, 2023 | Option Exercise | $0.62 | 1,085 | 668 | 172,618 | Dec 11, 2023, 04:21 PM |
| Chung Christine | SVP, China Operations | Dec 06, 2023 | Option Exercise | $0.58 | 18,182 | 10,546 | 334,837 | Dec 11, 2023, 04:20 PM |
| Wettig Thane | CEO | Dec 06, 2023 | Option Exercise | $0.58 | 1,680 | 974 | 282,241 | Dec 11, 2023, 04:19 PM |
| Wettig Thane | CEO | Nov 01, 2023 | Option Exercise | $0.55 | 21,841 | 11,949 | 283,921 | Nov 03, 2023, 04:20 PM |
| Wettig Thane | Interim CEO | Sep 22, 2023 | Option Exercise | $0.79 | 819 | 644 | 305,762 | Sep 25, 2023, 07:37 PM |
| Graham Juan | Chief Financial Officer | Sep 07, 2023 | Option Exercise | $0.99 | 1,096 | 1,088 | 189,276 | Sep 08, 2023, 05:03 PM |
| Graham Juan | Chief Financial Officer | Sep 06, 2023 | Option Exercise | $0.96 | 711 | 685 | 190,372 | Sep 08, 2023, 05:03 PM |
| Wettig Thane | Interim CEO | Sep 06, 2023 | Option Exercise | $0.96 | 1,680 | 1,618 | 306,581 | Sep 08, 2023, 05:00 PM |
| Eisner Mark | EVP, Chief Medical Officer | Sep 06, 2023 | Option Exercise | $0.96 | 1,860 | 1,791 | 159,917 | Sep 08, 2023, 04:59 PM |
| Chung Christine | SVP, China Operations | Sep 06, 2023 | Option Exercise | $0.96 | 3,308 | 3,186 | 353,019 | Sep 08, 2023, 04:58 PM |
| Eisner Mark | EVP, Chief Medical Officer | Sep 01, 2023 | Option Exercise | $1.06 | 1,085 | 1,150 | 161,777 | Sep 06, 2023, 08:55 PM |
| Henderson Jeffrey William | Director | Sep 01, 2023 | Sale | $1.03 | 2,000 | 2,060 | 28,866 | Sep 06, 2023, 08:54 PM |
| Henderson Jeffrey William | Director | Aug 04, 2023 | Sale | $1.91 | 2,000 | 3,820 | 30,866 | Aug 08, 2023, 07:10 PM |
| Henderson Jeffrey William | Director | Jul 11, 2023 | Sale | $2.69 | 2,000 | 5,380 | 32,866 | Jul 13, 2023, 08:28 PM |
| Conterno Enrique A | Chief Executive Officer | Jul 07, 2023 | Sale | $2.80 | 1,880 | 5,264 | 374,722 | Jul 10, 2023, 07:36 PM |
| Wettig Thane | Chief Commercial Officer | Jun 23, 2023 | Sale | $16.53 | 791 | 13,075 | 108,261 | Jun 26, 2023, 04:27 PM |
| Wettig Thane | Chief Commercial Officer | Jun 07, 2023 | Sale | $17.04 | 1,758 | 29,951 | 110,338 | Jun 22, 2023, 06:32 PM |
| Chung Christine | SVP, China Operations | Jun 14, 2023 | Sale | $16.79 | 6,250 | 104,925 | 237,327 | Jun 15, 2023, 08:17 PM |
| Chung Christine | SVP, China Operations | Jun 13, 2023 | Sale | $17.60 | 6,250 | 110,000 | 242,577 | Jun 15, 2023, 08:17 PM |
| Cravatt Benjamin | Director | Jun 09, 2023 | Sale | $17.17 | 3,944 | 67,717 | 30,914 | Jun 09, 2023, 07:56 PM |
| Brennan Aoife | Director | Jun 09, 2023 | Sale | $17.19 | 4,733 | 81,367 | 30,686 | Jun 09, 2023, 07:55 PM |
| Blaug Suzanne | Director | Jun 09, 2023 | Sale | $17.20 | 8,520 | 146,571 | 34,763 | Jun 09, 2023, 07:54 PM |
| Ho Maykin | Director | Jun 08, 2023 | Sale | $17.44 | 8,520 | 148,591 | 37,726 | Jun 09, 2023, 07:54 PM |
| EDWARDS JEFFREY L | Director | Jun 09, 2023 | Sale | $17.19 | 7,889 | 135,622 | 38,601 | Jun 09, 2023, 07:53 PM |
| Henderson Jeffrey William | Director | Jun 08, 2023 | Sale | $17.46 | 7,000 | 122,185 | 39,860 | Jun 09, 2023, 07:52 PM |
| Schoeneck James A | Director | Jun 07, 2023 | Sale | $18.03 | 7,100 | 127,987 | 73,722 | Jun 09, 2023, 07:51 PM |
| Wettig Thane | Chief Commercial Officer | Jun 07, 2023 | Sale | $17.04 | 1,758 | 29,951 | 112,681 | Jun 09, 2023, 07:39 PM |
| Graham Juan | Chief Financial Officer | Jun 07, 2023 | Sale | $16.99 | 1,785 | 30,320 | 71,818 | Jun 09, 2023, 07:39 PM |
| Chung Christine | SVP, China Operations | Jun 07, 2023 | Sale | $17.04 | 3,633 | 61,894 | 251,098 | Jun 09, 2023, 07:38 PM |
| Eisner Mark | EVP, Chief Medical Officer | Jun 07, 2023 | Sale | $17.04 | 2,042 | 34,792 | 162,862 | Jun 09, 2023, 07:12 PM |
| Conterno Enrique A | Chief Executive Officer | Jun 07, 2023 | Sale | $17.04 | 8,897 | 151,583 | 382,708 | Jun 09, 2023, 07:10 PM |
| Eisner Mark | EVP, Chief Medical Officer | Jun 02, 2023 | Sale | $18.83 | 1,090 | 20,525 | 164,904 | Jun 05, 2023, 04:22 PM |
| Conterno Enrique A | Chief Executive Officer | Apr 10, 2023 | Sale | $19.52 | 1,869 | 36,483 | 382,999 | Apr 11, 2023, 04:59 PM |
| Eisner Mark | Chief Medical Officer | Apr 04, 2023 | Sale | $18.78 | 9,182 | 172,473 | 165,994 | Apr 06, 2023, 04:32 PM |
| Chung Christine | SVP, China Operations | Apr 04, 2023 | Sale | $18.78 | 6,590 | 123,785 | 252,460 | Apr 06, 2023, 04:28 PM |
| Wettig Thane | Chief Commercial Officer | Mar 23, 2023 | Sale | $18.71 | 905 | 16,933 | 110,653 | Mar 24, 2023, 08:27 PM |
| Conterno Enrique A | Chief Executive Officer | Mar 10, 2023 | Sale | $20.20 | 19,489 | 393,625 | 384,868 | Mar 23, 2023, 04:50 PM |
| Chung Christine | SVP, China Operations | Mar 08, 2023 | Sale | $21.16 | 8,354 | 176,736 | 251,519 | Mar 10, 2023, 09:58 PM |
| Chung Christine | SVP, China Operations | Mar 10, 2023 | Sale | $20.20 | 7,606 | 153,621 | 261,964 | Mar 10, 2023, 09:58 PM |
| Conterno Enrique A | Chief Executive Officer | Mar 10, 2023 | Sale | $20.20 | 31,589 | 638,013 | 404,357 | Mar 10, 2023, 09:55 PM |
| Conterno Enrique A | Chief Executive Officer | Mar 08, 2023 | Sale | $21.16 | 24,672 | 521,958 | 356,111 | Mar 10, 2023, 09:55 PM |
| Eisner Mark | Chief Medical Officer | Mar 10, 2023 | Sale | $20.20 | 10,140 | 204,801 | 181,431 | Mar 10, 2023, 09:55 PM |
| Eisner Mark | Chief Medical Officer | Mar 08, 2023 | Sale | $21.16 | 7,363 | 155,771 | 165,133 | Mar 10, 2023, 09:55 PM |
| Graham Juan | Chief Financial Officer | Mar 10, 2023 | Sale | $20.20 | 4,912 | 99,209 | 76,668 | Mar 10, 2023, 09:54 PM |
| Graham Juan | Chief Financial Officer | Mar 08, 2023 | Sale | $21.16 | 2,749 | 58,158 | 70,213 | Mar 10, 2023, 09:54 PM |
| Wettig Thane | Chief Commercial Officer | Mar 10, 2023 | Sale | $20.20 | 7,669 | 154,893 | 116,289 | Mar 10, 2023, 09:53 PM |
| Wettig Thane | Chief Commercial Officer | Mar 08, 2023 | Sale | $21.16 | 6,265 | 132,542 | 104,090 | Mar 10, 2023, 09:53 PM |
| Eisner Mark | Chief Medical Officer | Mar 02, 2023 | Sale | $21.87 | 1,187 | 25,960 | 172,496 | Mar 06, 2023, 04:59 PM |
| Conterno Enrique A | Chief Executive Officer | Jan 06, 2023 | Sale | $19.95 | 1,538 | 30,683 | 295,483 | Jan 10, 2023, 04:46 PM |
| Chung Christine | SVP, China Operations | Dec 08, 2022 | Sale | $15.79 | 2,595 | 40,975 | 234,873 | Jan 04, 2023, 06:35 PM |
| Chung Christine | SVP, China Operations | Sep 06, 2022 | Option Exercise | $12.26 | 1,851 | 22,693 | 242,151 | Jan 04, 2023, 06:33 PM |
| Wettig Thane | Chief Commercial Officer | Dec 23, 2022 | Sale | $15.80 | 734 | 11,597 | 89,163 | Dec 28, 2022, 06:38 PM |
| Graham Juan | Chief Financial Officer | Dec 12, 2022 | Sale | $14.50 | 1,407 | 20,402 | 47,962 | Dec 15, 2022, 05:23 PM |
| Graham Juan | Chief Financial Officer | Dec 09, 2022 | Sale | $14.89 | 781 | 11,629 | 49,369 | Dec 15, 2022, 05:23 PM |
| Graham Juan | Chief Financial Officer | Dec 08, 2022 | Sale | $14.89 | 5,741 | 85,498 | 50,628 | Dec 15, 2022, 05:23 PM |
| Graham Juan | Chief Financial Officer | Dec 12, 2022 | Sale | $14.50 | 1,407 | 20,402 | 53,703 | Dec 14, 2022, 09:55 PM |
| Graham Juan | Chief Financial Officer | Dec 09, 2022 | Sale | $14.90 | 781 | 11,637 | 55,110 | Dec 14, 2022, 09:55 PM |
| Chung Christine | SVP, China Operations | Dec 08, 2022 | Sale | $15.79 | 1,096 | 17,306 | 237,705 | Dec 09, 2022, 07:22 PM |
| Wettig Thane | Chief Commercial Officer | Dec 08, 2022 | Sale | $15.79 | 382 | 6,032 | 89,897 | Dec 09, 2022, 07:21 PM |
| Conterno Enrique A | Chief Executive Officer | Dec 08, 2022 | Sale | $15.79 | 2,543 | 40,154 | 297,020 | Dec 09, 2022, 07:19 PM |
| Eisner Mark | Chief Medical Officer | Dec 01, 2022 | Option Exercise | $15.04 | 1,084 | 16,303 | 141,183 | Dec 02, 2022, 05:41 PM |
| Conterno Enrique A | Chief Executive Officer | Oct 06, 2022 | Option Exercise | $14.26 | 1,296 | 18,481 | 299,563 | Oct 11, 2022, 05:06 PM |
| Chung Christine | SVP, China Operations | Sep 30, 2022 | Option Exercise | $13.01 | 4,683 | 60,926 | 238,801 | Oct 04, 2022, 05:30 PM |
| Eisner Mark | Chief Medical Officer | Sep 30, 2022 | Option Exercise | $13.01 | 6,777 | 88,169 | 142,267 | Oct 04, 2022, 05:21 PM |
| Wettig Thane | Chief Commercial Officer | Sep 22, 2022 | Option Exercise | $12.26 | 655 | 8,030 | 90,279 | Sep 26, 2022, 04:27 PM |
| Graham Juan | Chief Financial Officer | Sep 07, 2022 | Option Exercise | $12.62 | 3,009 | 37,974 | 55,891 | Sep 08, 2022, 06:59 PM |
| Chung Christine | SVP, China Operations | Sep 06, 2022 | Option Exercise | $12.26 | 518 | 6,351 | 243,484 | Sep 08, 2022, 06:57 PM |
| Wettig Thane | Chief Commercial Officer | Sep 06, 2022 | Option Exercise | $12.26 | 360 | 4,414 | 90,934 | Sep 08, 2022, 06:54 PM |
| Conterno Enrique A | Chief Executive Officer | Sep 06, 2022 | Option Exercise | $12.26 | 1,772 | 21,725 | 300,859 | Sep 08, 2022, 06:53 PM |
| Eisner Mark | Chief Medical Officer | Sep 01, 2022 | Option Exercise | $13.09 | 756 | 9,896 | 149,044 | Sep 02, 2022, 05:30 PM |
| Conterno Enrique A | Chief Executive Officer | Jul 06, 2022 | Option Exercise | $12.40 | 1,296 | 16,070 | 302,631 | Jul 08, 2022, 04:42 PM |
| Wettig Thane | Chief Commercial Officer | Jun 22, 2022 | Option Exercise | $11.42 | 655 | 7,480 | 91,294 | Jun 24, 2022, 05:27 PM |
| Chung Christine | SVP, China Operations | Jun 06, 2022 | Option Exercise | $9.50 | 1,850 | 17,575 | 244,002 | Jun 08, 2022, 07:24 PM |
| Conterno Enrique A | Chief Executive Officer | Jun 06, 2022 | Option Exercise | $9.50 | 1,772 | 16,834 | 301,940 | Jun 08, 2022, 07:23 PM |
| Wettig Thane | Chief Commercial Officer | Jun 06, 2022 | Option Exercise | $9.50 | 360 | 3,420 | 89,961 | Jun 08, 2022, 07:22 PM |
| Conterno Enrique A | Chief Executive Officer | Apr 07, 2022 | Option Exercise | $12.73 | 1,311 | 16,689 | 303,712 | Apr 08, 2022, 04:07 PM |
| Chung Christine | SVP, China Operations | Mar 31, 2022 | Option Exercise | $12.02 | 4,682 | 56,278 | 245,852 | Apr 01, 2022, 07:29 PM |
| Eisner Mark | Chief Medical Officer | Mar 31, 2022 | Option Exercise | $12.02 | 6,442 | 77,433 | 150,941 | Apr 01, 2022, 07:28 PM |
| Wettig Thane | Chief Commercial Officer | Mar 22, 2022 | Option Exercise | $13.31 | 655 | 8,718 | 90,321 | Mar 24, 2022, 07:57 PM |
| Wettig Thane | Chief Commercial Officer | Mar 07, 2022 | Option Exercise | $12.69 | 1,706 | 21,649 | 90,976 | Mar 09, 2022, 05:46 PM |
| Chung Christine | SVP, China Operations | Mar 07, 2022 | Option Exercise | $12.69 | 3,905 | 49,554 | 250,534 | Mar 09, 2022, 05:45 PM |
| Conterno Enrique A | Chief Executive Officer | Mar 07, 2022 | Option Exercise | $12.69 | 7,081 | 89,858 | 305,023 | Mar 09, 2022, 05:43 PM |
| Eisner Mark | Chief Medical Officer | Mar 01, 2022 | Option Exercise | $13.62 | 756 | 10,297 | 157,383 | Mar 03, 2022, 04:04 PM |
| Conterno Enrique A | Chief Executive Officer | Jan 06, 2022 | Option Exercise | $13.93 | 1,536 | 21,396 | 132,704 | Jan 07, 2022, 05:37 PM |
| Eisner Mark | Chief Medical Officer | Jan 03, 2022 | Option Exercise | $14.82 | 7,043 | 104,377 | 98,139 | Jan 05, 2022, 04:44 PM |
| Chung Christine | SVP, China Operations | Jan 03, 2022 | Option Exercise | $14.82 | 5,284 | 78,309 | 209,439 | Jan 05, 2022, 04:41 PM |
| Wettig Thane | Chief Commercial Officer | Dec 22, 2021 | Option Exercise | $14.97 | 517 | 7,739 | 47,682 | Dec 23, 2021, 05:17 PM |
| Chung Christine | SVP, China Operations | Dec 06, 2021 | Option Exercise | $14.19 | 2,668 | 37,859 | 214,723 | Dec 08, 2021, 04:02 PM |
| Eisner Mark | Chief Medical Officer | Dec 01, 2021 | Option Exercise | $12.65 | 4,338 | 54,876 | 105,182 | Dec 03, 2021, 04:03 PM |
| Conterno Enrique A | Chief Executive Officer | Oct 06, 2021 | Option Exercise | $10.20 | 1,859 | 18,962 | 134,239 | Oct 08, 2021, 05:03 PM |
| Wettig Thane | Chief Commercial Officer | Sep 22, 2021 | Option Exercise | $10.18 | 620 | 6,312 | 48,196 | Sep 24, 2021, 04:02 PM |
| KEARNS THOMAS F JR | Director | Sep 15, 2021 | Sale | $11.58 | 13,100 | 151,707 | 39,764 | Sep 17, 2021, 04:02 PM |
| Cotroneo Pat | Executive Advisor & Former CFO | Sep 07, 2021 | Option Exercise | $12.41 | 2,141 | 26,570 | 274,536 | Sep 09, 2021, 09:35 PM |
| Chung Christine | SVP, China Operations | Sep 07, 2021 | Option Exercise | $12.41 | 2,030 | 25,192 | 165,251 | Sep 09, 2021, 09:33 PM |
| Wettig Thane | Chief Commercial Officer | Aug 26, 2021 | Buy | $11.53 | 3,100 | 35,743 | 48,816 | Aug 30, 2021, 08:11 PM |
| Conterno Enrique A | Chief Executive Officer | Jul 06, 2021 | Option Exercise | $25.06 | 1,859 | 46,587 | 136,098 | Jul 08, 2021, 08:31 PM |
| Chung Christine | SVP, China Operations | Jun 07, 2021 | Option Exercise | $22.90 | 2,030 | 46,487 | 165,251 | Jun 09, 2021, 07:26 PM |
| KEARNS THOMAS F JR | Director | Mar 11, 2021 | Option Exercise | $3.50 | 18,000 | 63,000 | 166,164 | Mar 15, 2021, 06:22 PM |
| KEARNS THOMAS F JR | Director | Mar 11, 2021 | Sale | $35.02 | 18,000 | 630,360 | 148,164 | Mar 15, 2021, 06:22 PM |
| Kouchakji Elias | SVP, Clinical Dev, Drug Safety | Mar 08, 2021 | Option Exercise | $33.37 | 5,221 | 174,225 | 147,346 | Mar 10, 2021, 05:38 PM |
| Cotroneo Pat | SVP, Finance and CFO | Mar 08, 2021 | Option Exercise | $33.37 | 5,657 | 188,774 | 282,187 | Mar 10, 2021, 05:34 PM |
| Chung Christine | SVP, China Operations | Mar 08, 2021 | Option Exercise | $33.37 | 5,679 | 189,508 | 166,597 | Mar 10, 2021, 05:32 PM |
| Kurkijarvi Kalevi | Director | Feb 17, 2021 | Option Exercise | $28.65 | 6,000 | 171,900 | 39,100 | Feb 19, 2021, 07:10 PM |
| Kurkijarvi Kalevi | Director | Feb 17, 2021 | Sale | $52.40 | 6,000 | 314,383 | 33,944 | Feb 19, 2021, 07:10 PM |
| Kurkijarvi Kalevi | Director | Jan 19, 2021 | Option Exercise | $19.05 | 6,000 | 114,300 | 39,100 | Jan 21, 2021, 07:24 PM |
| Kurkijarvi Kalevi | Director | Jan 19, 2021 | Sale | $43.38 | 6,000 | 260,280 | 33,100 | Jan 21, 2021, 07:24 PM |
| Kurkijarvi Kalevi | Director | Jan 14, 2021 | Option Exercise | $19.05 | 5,999 | 114,281 | 39,099 | Jan 15, 2021, 08:02 PM |
| Kurkijarvi Kalevi | Director | Jan 14, 2021 | Sale | $40.04 | 5,999 | 240,200 | 33,100 | Jan 15, 2021, 08:02 PM |
| Conterno Enrique A | Chief Executive Officer | Jan 06, 2021 | Option Exercise | $38.31 | 5,411 | 207,295 | 55,273 | Jan 08, 2021, 07:40 PM |
| Schoeneck James A | Director | Jan 04, 2021 | Option Exercise | $9.77 | 6,000 | 58,650 | 15,400 | Jan 06, 2021, 07:08 PM |
| Kurkijarvi Kalevi | Director | Dec 28, 2020 | Option Exercise | $18.34 | 6,001 | 110,059 | 39,101 | Dec 30, 2020, 06:07 PM |
| Kurkijarvi Kalevi | Director | Dec 28, 2020 | Sale | $40.40 | 6,001 | 242,455 | 33,200 | Dec 30, 2020, 06:07 PM |
| Yu K Peony | Chief Medical Officer | Dec 16, 2020 | Sale | $41.61 | 3,350 | 139,394 | 192,292 | Dec 17, 2020, 07:06 PM |
| Cotroneo Pat | SVP, Finance and CFO | Dec 15, 2020 | Sale | $43.60 | 3,068 | 133,765 | 266,144 | Dec 17, 2020, 07:04 PM |
| Yu K Peony | Chief Medical Officer | Dec 07, 2020 | Option Exercise | $41.99 | 3,292 | 138,231 | 195,642 | Dec 09, 2020, 07:34 PM |
| Kouchakji Elias | SVP, Clinical Dev, Drug Safety | Dec 07, 2020 | Option Exercise | $41.99 | 2,728 | 114,549 | 131,767 | Dec 09, 2020, 07:33 PM |
| Cotroneo Pat | SVP, Finance and CFO | Dec 07, 2020 | Option Exercise | $41.99 | 3,014 | 126,558 | 269,212 | Dec 09, 2020, 07:30 PM |
| Chung Christine | SVP, China Operations | Dec 07, 2020 | Option Exercise | $41.99 | 3,039 | 127,608 | 150,576 | Dec 09, 2020, 07:27 PM |
| Kouchakji Elias | SVP, Clinical Dev, Drug Safety | Nov 17, 2020 | Option Exercise | $14.57 | 7,082 | 103,220 | 134,495 | Nov 19, 2020, 04:52 PM |
| Yu K Peony | Chief Medical Officer | Sep 16, 2020 | Sale | $44.01 | 3,351 | 147,478 | 198,934 | Sep 18, 2020, 05:19 PM |
| Cotroneo Pat | SVP, Finance and CFO | Sep 15, 2020 | Sale | $43.63 | 3,070 | 133,944 | 272,226 | Sep 17, 2020, 06:03 PM |
| Yu K Peony | Chief Medical Officer | Sep 08, 2020 | Option Exercise | $42.16 | 3,291 | 138,749 | 202,285 | Sep 10, 2020, 07:36 PM |
| Kouchakji Elias | SVP, Clinical Dev, Drug Safety | Sep 08, 2020 | Option Exercise | $42.16 | 2,728 | 115,012 | 127,413 | Sep 10, 2020, 07:32 PM |
| Cotroneo Pat | SVP, Finance and CFO | Sep 08, 2020 | Option Exercise | $42.16 | 3,014 | 127,070 | 275,296 | Sep 10, 2020, 07:30 PM |
| Chung Christine | SVP, China Operations | Sep 08, 2020 | Option Exercise | $42.16 | 3,038 | 128,082 | 153,615 | Sep 10, 2020, 07:28 PM |
| Yu K Peony | Chief Medical Officer | Sep 03, 2020 | Option Exercise | $18.00 | 10,000 | 180,000 | 215,576 | Sep 04, 2020, 04:33 PM |
| Yu K Peony | Chief Medical Officer | Sep 03, 2020 | Sale | $50.89 | 10,000 | 508,900 | 205,576 | Sep 04, 2020, 04:33 PM |
| Cotroneo Pat | SVP, Finance and CFO | Sep 03, 2020 | Option Exercise | $23.30 | 15,004 | 349,582 | 293,314 | Sep 04, 2020, 04:30 PM |
| Cotroneo Pat | SVP, Finance and CFO | Sep 03, 2020 | Sale | $50.91 | 15,004 | 763,854 | 278,310 | Sep 04, 2020, 04:30 PM |
| Schoeneck James A | Director | Aug 20, 2020 | Option Exercise | $5.95 | 6,000 | 35,700 | 15,400 | Aug 21, 2020, 05:58 PM |
| Cotroneo Pat | SVP, Finance and CFO | Aug 11, 2020 | Option Exercise | $18.72 | 7,250 | 135,712 | 278,310 | Aug 11, 2020, 04:34 PM |
| Cotroneo Pat | SVP, Finance and CFO | Aug 07, 2020 | Option Exercise | $19.39 | 22,554 | 437,322 | 293,614 | Aug 11, 2020, 04:34 PM |
| Cotroneo Pat | SVP, Finance and CFO | Aug 07, 2020 | Sale | $48.00 | 22,554 | 1,082,592 | 271,060 | Aug 11, 2020, 04:34 PM |
| Yu K Peony | Chief Medical Officer | Jul 24, 2020 | Sale | $42.35 | 3,351 | 141,915 | 205,576 | Jul 28, 2020, 07:33 PM |
| Cotroneo Pat | SVP, Finance and CFO | Jun 16, 2020 | Sale | $39.68 | 3,928 | 155,863 | 271,060 | Jun 18, 2020, 06:35 PM |
| Conterno Enrique A | Chief Executive Officer | Jun 10, 2020 | Buy | $36.29 | 8,000 | 290,282 | 8,000 | Jun 12, 2020, 06:59 AM |
| Conterno Enrique A | Chief Executive Officer | Jun 11, 2020 | Buy | $35.28 | 19,800 | 698,599 | 27,800 | Jun 12, 2020, 06:59 AM |
| Rosenkranz Roberto Pedro | Director | Jun 09, 2020 | Option Exercise | $23.85 | 24,000 | 572,400 | 96,100 | Jun 11, 2020, 09:22 PM |
| Chung Christine | SVP, China Operations | Jun 08, 2020 | Option Exercise | $33.61 | 3,038 | 102,107 | 156,653 | Jun 10, 2020, 07:48 PM |
| Cotroneo Pat | SVP, Finance and CFO | Jun 08, 2020 | Option Exercise | $33.61 | 2,156 | 72,463 | 274,988 | Jun 10, 2020, 07:47 PM |
| Yu K Peony | Chief Medical Officer | Jun 08, 2020 | Option Exercise | $33.61 | 3,292 | 110,644 | 208,927 | Jun 10, 2020, 07:46 PM |
| Kouchakji Elias | SVP, Clinical Dev, Drug Safety | Jun 08, 2020 | Option Exercise | $33.61 | 2,728 | 91,688 | 130,141 | Jun 10, 2020, 07:45 PM |
| KEARNS THOMAS F JR | Director | Mar 19, 2020 | Option Exercise | $2.90 | 18,000 | 52,200 | 161,464 | Mar 23, 2020, 05:37 PM |
| KEARNS THOMAS F JR | Director | Mar 19, 2020 | Sale | $23.17 | 18,000 | 417,074 | 143,464 | Mar 23, 2020, 05:37 PM |
| Chung Christine | SVP, China Operations | Mar 06, 2020 | Option Exercise | $39.71 | 10,126 | 402,103 | 122,518 | Mar 19, 2020, 07:55 PM |
| Chung Christine | SVP, China Operations | Mar 19, 2020 | Option Exercise | $25.40 | 7,345 | 186,563 | 166,358 | Mar 19, 2020, 07:55 PM |
| Chung Christine | SVP, China Operations | Mar 18, 2020 | Option Exercise | $25.40 | 400 | 10,160 | 162,918 | Mar 19, 2020, 07:55 PM |
| Chung Christine | SVP, China Operations | Mar 19, 2020 | Sale | $25.91 | 7,345 | 190,282 | 166,058 | Mar 19, 2020, 07:55 PM |
| Chung Christine | SVP, China Operations | Mar 18, 2020 | Sale | $24.79 | 3,905 | 96,799 | 162,013 | Mar 19, 2020, 07:55 PM |
| Yu K Peony | Chief Medical Officer | Mar 06, 2020 | Option Exercise | $39.71 | 9,826 | 390,190 | 162,791 | Mar 18, 2020, 08:05 PM |
| Yu K Peony | Chief Medical Officer | Mar 16, 2020 | Option Exercise | $19.39 | 3,750 | 72,712 | 166,541 | Mar 18, 2020, 08:05 PM |
| Kouchakji Elias | SVP, Clinical Dev, Drug Safety | Mar 06, 2020 | Option Exercise | $39.71 | 6,525 | 259,108 | 94,691 | Mar 18, 2020, 08:03 PM |
| Cotroneo Pat | SVP, Finance and CFO | Mar 06, 2020 | Option Exercise | $39.71 | 4,881 | 193,825 | 245,705 | Mar 18, 2020, 08:00 PM |
| Cotroneo Pat | SVP, Finance and CFO | Mar 16, 2020 | Sale | $26.36 | 9,239 | 243,540 | 236,466 | Mar 18, 2020, 08:00 PM |
| Chung Christine | SVP, China Operations | Feb 12, 2020 | Option Exercise | $25.40 | 5,625 | 142,875 | 138,269 | Feb 13, 2020, 05:36 PM |
| Chung Christine | SVP, China Operations | Feb 11, 2020 | Option Exercise | $25.40 | 5,625 | 142,875 | 138,269 | Feb 13, 2020, 05:36 PM |
| Chung Christine | SVP, China Operations | Feb 11, 2020 | Sale | $44.48 | 5,625 | 250,200 | 132,644 | Feb 13, 2020, 05:36 PM |
| Chung Christine | SVP, China Operations | Feb 12, 2020 | Sale | $45.98 | 5,625 | 258,616 | 133,244 | Feb 13, 2020, 05:36 PM |
| Kurkijarvi Kalevi | Director | Feb 10, 2020 | Option Exercise | $18.34 | 6,000 | 110,040 | 34,400 | Feb 12, 2020, 09:52 PM |
| Kurkijarvi Kalevi | Director | Feb 10, 2020 | Sale | $42.69 | 6,000 | 256,140 | 28,400 | Feb 12, 2020, 09:52 PM |
| Schoeneck James A | Interim President | Jan 06, 2020 | Option Exercise | $43.35 | 10,928 | 473,729 | 22,422 | Jan 08, 2020, 09:16 PM |
| Kurkijarvi Kalevi | Director | Jan 06, 2020 | Option Exercise | $18.00 | 6,000 | 108,000 | 34,400 | Jan 08, 2020, 09:14 PM |
| Kurkijarvi Kalevi | Director | Jan 06, 2020 | Sale | $42.66 | 6,000 | 255,960 | 28,400 | Jan 08, 2020, 09:14 PM |
| Chung Christine | SVP, China Operations | Jan 07, 2020 | Option Exercise | $25.40 | 5,625 | 142,875 | 138,269 | Jan 08, 2020, 09:12 PM |
| Chung Christine | SVP, China Operations | Jan 06, 2020 | Option Exercise | $25.40 | 5,625 | 142,875 | 138,269 | Jan 08, 2020, 09:12 PM |
| Chung Christine | SVP, China Operations | Jan 07, 2020 | Sale | $42.76 | 5,625 | 240,525 | 132,644 | Jan 08, 2020, 09:12 PM |
| Chung Christine | SVP, China Operations | Jan 06, 2020 | Sale | $42.98 | 5,625 | 241,762 | 132,644 | Jan 08, 2020, 09:12 PM |
| Cotroneo Pat | SVP, Finance and CFO | Dec 20, 2019 | Option Exercise | $7.81 | 56,254 | 439,427 | 310,042 | Dec 26, 2019, 04:25 PM |
| Cotroneo Pat | SVP, Finance and CFO | Dec 20, 2019 | Sale | $45.67 | 59,456 | 2,715,517 | 263,315 | Dec 26, 2019, 04:25 PM |
| Chung Christine | SVP, China Operations | Dec 17, 2019 | Option Exercise | $25.40 | 5,625 | 142,875 | 138,269 | Dec 18, 2019, 08:33 PM |
| Chung Christine | SVP, China Operations | Dec 16, 2019 | Option Exercise | $25.40 | 2,120 | 53,848 | 138,269 | Dec 18, 2019, 08:33 PM |
| Chung Christine | SVP, China Operations | Dec 17, 2019 | Sale | $46.98 | 5,625 | 264,244 | 132,933 | Dec 18, 2019, 08:33 PM |
| Chung Christine | SVP, China Operations | Dec 16, 2019 | Sale | $47.08 | 5,625 | 264,832 | 135,419 | Dec 18, 2019, 08:33 PM |
| Yu K Peony | Chief Medical Officer | Dec 16, 2019 | Sale | $46.68 | 3,420 | 159,646 | 172,617 | Dec 17, 2019, 08:38 PM |
| Kurkijarvi Kalevi | Director | Dec 09, 2019 | Option Exercise | $18.00 | 6,000 | 108,000 | 34,400 | Dec 12, 2019, 06:08 PM |
| Kurkijarvi Kalevi | Director | Dec 09, 2019 | Sale | $47.50 | 6,000 | 285,000 | 28,400 | Dec 12, 2019, 06:08 PM |
| Kouchakji Elias | SVP, Clinical Dev, Drug Safety | Dec 06, 2019 | Option Exercise | $47.39 | 2,442 | 115,726 | 101,216 | Dec 09, 2019, 08:13 PM |
| Cotroneo Pat | SVP, Finance and CFO | Dec 06, 2019 | Option Exercise | $47.39 | 3,144 | 148,994 | 253,788 | Dec 09, 2019, 08:11 PM |
| Chung Christine | SVP, China Operations | Dec 06, 2019 | Option Exercise | $47.39 | 3,479 | 164,870 | 136,149 | Dec 09, 2019, 08:10 PM |
| Yu K Peony | Chief Medical Officer | Dec 06, 2019 | Option Exercise | $47.39 | 3,360 | 159,230 | 176,037 | Dec 06, 2019, 07:51 PM |
| Yu K Peony | Chief Medical Officer | Dec 04, 2019 | Option Exercise | $17.46 | 4,157 | 72,576 | 179,397 | Dec 06, 2019, 07:51 PM |
| Chung Christine | SVP, China Operations | Nov 14, 2019 | Option Exercise | $21.84 | 5,625 | 122,838 | 145,253 | Nov 15, 2019, 06:07 PM |
| Chung Christine | SVP, China Operations | Nov 13, 2019 | Option Exercise | $19.39 | 5,625 | 109,069 | 145,253 | Nov 15, 2019, 06:07 PM |
| Chung Christine | SVP, China Operations | Nov 13, 2019 | Sale | $34.54 | 5,625 | 194,288 | 139,628 | Nov 15, 2019, 06:07 PM |
| Chung Christine | SVP, China Operations | Nov 14, 2019 | Sale | $34.74 | 5,625 | 195,440 | 141,653 | Nov 15, 2019, 06:07 PM |
| Cotroneo Pat | SVP, Finance and CFO | Nov 08, 2019 | Option Exercise | $2.90 | 12,500 | 36,250 | 256,932 | Nov 12, 2019, 09:15 PM |
| Kurkijarvi Kalevi | Director | Nov 07, 2019 | Option Exercise | $9.77 | 6,000 | 58,650 | 34,400 | Nov 08, 2019, 06:05 PM |
| Kurkijarvi Kalevi | Director | Nov 07, 2019 | Sale | $38.27 | 6,000 | 229,624 | 29,886 | Nov 08, 2019, 06:05 PM |
| Chung Christine | SVP, China Operations | Oct 09, 2019 | Option Exercise | $19.39 | 5,625 | 109,069 | 145,253 | Oct 10, 2019, 07:57 PM |
| Chung Christine | SVP, China Operations | Oct 08, 2019 | Option Exercise | $19.39 | 5,625 | 109,069 | 145,253 | Oct 10, 2019, 07:57 PM |
| Chung Christine | SVP, China Operations | Oct 09, 2019 | Sale | $36.58 | 5,625 | 205,763 | 139,628 | Oct 10, 2019, 07:57 PM |
| Chung Christine | SVP, China Operations | Oct 08, 2019 | Sale | $36.78 | 5,625 | 206,914 | 142,028 | Oct 10, 2019, 07:57 PM |
| Kurkijarvi Kalevi | Director | Oct 07, 2019 | Option Exercise | $9.77 | 6,000 | 58,650 | 34,400 | Oct 09, 2019, 08:26 PM |
| Kurkijarvi Kalevi | Director | Oct 07, 2019 | Sale | $36.73 | 6,000 | 220,380 | 28,400 | Oct 09, 2019, 08:26 PM |
| Chung Christine | SVP, China Operations | Sep 20, 2019 | Option Exercise | $19.39 | 5,625 | 109,069 | 145,253 | Sep 23, 2019, 06:57 PM |
| Chung Christine | SVP, China Operations | Sep 19, 2019 | Option Exercise | $19.39 | 2,120 | 41,107 | 145,253 | Sep 23, 2019, 06:57 PM |
| Chung Christine | SVP, China Operations | Sep 20, 2019 | Sale | $39.87 | 5,625 | 224,269 | 139,628 | Sep 23, 2019, 06:57 PM |
| Chung Christine | SVP, China Operations | Sep 19, 2019 | Sale | $40.45 | 5,625 | 227,550 | 143,028 | Sep 23, 2019, 06:57 PM |
| Yu K Peony | Chief Medical Officer | Sep 16, 2019 | Sale | $40.92 | 3,419 | 139,905 | 175,240 | Sep 18, 2019, 07:45 PM |
| Cotroneo Pat | SVP, Finance and CFO | Sep 17, 2019 | Sale | $41.38 | 3,201 | 132,457 | 244,432 | Sep 18, 2019, 07:42 PM |
| Yu K Peony | Chief Medical Officer | Sep 06, 2019 | Option Exercise | $41.68 | 8,317 | 346,653 | 178,659 | Sep 10, 2019, 08:33 PM |
| Kouchakji Elias | SVP, Clinical Dev, Drug Safety | Sep 06, 2019 | Option Exercise | $41.68 | 5,541 | 230,949 | 103,658 | Sep 10, 2019, 08:31 PM |
| Kurkijarvi Kalevi | Director | Sep 09, 2019 | Option Exercise | $5.95 | 6,000 | 35,700 | 34,400 | Sep 10, 2019, 08:29 PM |
| Kurkijarvi Kalevi | Director | Sep 09, 2019 | Sale | $40.95 | 6,000 | 245,723 | 28,820 | Sep 10, 2019, 08:29 PM |
| Cotroneo Pat | SVP, Finance and CFO | Sep 06, 2019 | Option Exercise | $41.68 | 3,144 | 131,042 | 247,633 | Sep 10, 2019, 08:28 PM |
| Chung Christine | SVP, China Operations | Sep 06, 2019 | Option Exercise | $41.68 | 8,437 | 351,654 | 143,133 | Sep 10, 2019, 08:26 PM |
| Chung Christine | SVP, China Operations | Aug 23, 2019 | Option Exercise | $19.39 | 5,625 | 109,069 | 157,195 | Aug 26, 2019, 07:33 PM |
| Chung Christine | SVP, China Operations | Aug 22, 2019 | Option Exercise | $19.39 | 5,625 | 109,069 | 157,195 | Aug 26, 2019, 07:33 PM |
| Chung Christine | SVP, China Operations | Aug 22, 2019 | Sale | $43.84 | 5,625 | 246,583 | 151,870 | Aug 26, 2019, 07:33 PM |
| Chung Christine | SVP, China Operations | Aug 23, 2019 | Sale | $42.51 | 5,625 | 239,099 | 153,970 | Aug 26, 2019, 07:33 PM |
| Neff Thomas B | Chief Executive Officer | Aug 21, 2019 | Option Exercise | $2.90 | 6,834 | 19,819 | 2,356,578 | Aug 23, 2019, 04:49 PM |
| Neff Thomas B | Chief Executive Officer | Aug 22, 2019 | Option Exercise | $2.90 | 6,834 | 19,819 | 2,345,012 | Aug 23, 2019, 04:49 PM |
| Neff Thomas B | Chief Executive Officer | Aug 21, 2019 | Sale | $44.79 | 18,400 | 824,136 | 2,338,178 | Aug 23, 2019, 04:49 PM |
| Neff Thomas B | Chief Executive Officer | Aug 22, 2019 | Sale | $43.77 | 1,418 | 62,066 | 44,238 | Aug 23, 2019, 04:49 PM |
| Neff Thomas B | Chief Executive Officer | Aug 22, 2019 | Sale | $43.87 | 18,400 | 807,129 | 2,327,912 | Aug 23, 2019, 04:49 PM |
| Neff Thomas B | Chief Executive Officer | Aug 21, 2019 | Sale | $44.81 | 1,418 | 63,541 | 45,656 | Aug 23, 2019, 04:49 PM |
| Neff Thomas B | Chief Executive Officer | Aug 12, 2019 | Option Exercise | $2.90 | 6,834 | 19,819 | 2,379,710 | Aug 14, 2019, 05:38 PM |
| Neff Thomas B | Chief Executive Officer | Aug 13, 2019 | Option Exercise | $2.90 | 6,834 | 19,819 | 2,368,144 | Aug 14, 2019, 05:38 PM |
| Neff Thomas B | Chief Executive Officer | Aug 12, 2019 | Sale | $45.24 | 18,400 | 832,329 | 2,369,010 | Aug 14, 2019, 05:38 PM |
| Neff Thomas B | Chief Executive Officer | Aug 13, 2019 | Sale | $45.61 | 1,418 | 64,680 | 47,574 | Aug 14, 2019, 05:38 PM |
| Neff Thomas B | Chief Executive Officer | Aug 13, 2019 | Sale | $45.65 | 18,400 | 840,006 | 2,356,644 | Aug 14, 2019, 05:38 PM |
| Neff Thomas B | Chief Executive Officer | Aug 12, 2019 | Sale | $45.17 | 1,418 | 64,056 | 48,792 | Aug 14, 2019, 05:38 PM |
| Kurkijarvi Kalevi | Director | Aug 05, 2019 | Option Exercise | $3.50 | 6,000 | 21,000 | 34,400 | Aug 07, 2019, 04:42 PM |
| Kurkijarvi Kalevi | Director | Aug 05, 2019 | Sale | $45.22 | 6,000 | 271,320 | 28,400 | Aug 07, 2019, 04:42 PM |
| Neff Thomas B | Chief Executive Officer | Jul 25, 2019 | Option Exercise | $2.90 | 6,834 | 19,819 | 2,391,276 | Jul 26, 2019, 05:31 PM |
| Neff Thomas B | Chief Executive Officer | Jul 24, 2019 | Option Exercise | $2.90 | 6,834 | 19,819 | 2,402,842 | Jul 26, 2019, 05:31 PM |
| Neff Thomas B | Chief Executive Officer | Jul 24, 2019 | Sale | $46.57 | 1,418 | 66,036 | 51,328 | Jul 26, 2019, 05:31 PM |
| Neff Thomas B | Chief Executive Officer | Jul 24, 2019 | Sale | $46.54 | 18,400 | 856,336 | 2,384,442 | Jul 26, 2019, 05:31 PM |
| Neff Thomas B | Chief Executive Officer | Jul 25, 2019 | Sale | $46.88 | 1,418 | 66,472 | 50,010 | Jul 26, 2019, 05:31 PM |
| Neff Thomas B | Chief Executive Officer | Jul 25, 2019 | Sale | $46.95 | 18,400 | 863,858 | 2,374,776 | Jul 26, 2019, 05:31 PM |
| Neff Thomas B | Chief Executive Officer | Jul 10, 2019 | Option Exercise | $2.90 | 6,834 | 19,819 | 2,425,974 | Jul 12, 2019, 04:27 PM |
| Neff Thomas B | Chief Executive Officer | Jul 11, 2019 | Option Exercise | $2.90 | 6,834 | 19,819 | 2,414,408 | Jul 12, 2019, 04:27 PM |
| Neff Thomas B | Chief Executive Officer | Jul 10, 2019 | Sale | $44.81 | 1,418 | 63,541 | 54,164 | Jul 12, 2019, 04:27 PM |
| Neff Thomas B | Chief Executive Officer | Jul 10, 2019 | Sale | $44.80 | 18,400 | 824,300 | 2,413,807 | Jul 12, 2019, 04:27 PM |
| Neff Thomas B | Chief Executive Officer | Jul 11, 2019 | Sale | $45.09 | 1,418 | 63,938 | 52,746 | Jul 12, 2019, 04:27 PM |
| Neff Thomas B | Chief Executive Officer | Jul 11, 2019 | Sale | $45.15 | 18,400 | 830,836 | 2,396,508 | Jul 12, 2019, 04:27 PM |
| Chung Christine | SVP, China Operations | Jul 11, 2019 | Option Exercise | $28.21 | 5,625 | 158,663 | 157,195 | Jul 12, 2019, 04:23 PM |
| Chung Christine | SVP, China Operations | Jul 10, 2019 | Option Exercise | $29.66 | 5,625 | 166,837 | 157,195 | Jul 12, 2019, 04:23 PM |
| Chung Christine | SVP, China Operations | Jul 11, 2019 | Sale | $45.14 | 5,625 | 253,915 | 151,670 | Jul 12, 2019, 04:23 PM |
| Chung Christine | SVP, China Operations | Jul 10, 2019 | Sale | $44.79 | 5,625 | 251,953 | 152,170 | Jul 12, 2019, 04:23 PM |
| Kurkijarvi Kalevi | Director | Jul 08, 2019 | Option Exercise | $3.50 | 6,000 | 21,000 | 34,400 | Jul 10, 2019, 08:18 PM |
| Kurkijarvi Kalevi | Director | Jul 08, 2019 | Sale | $42.59 | 6,000 | 255,570 | 29,800 | Jul 10, 2019, 08:18 PM |
| Kouchakji Elias | SVP, Clinical Dev, Drug Safety | Jun 28, 2019 | Sale | $45.00 | 2,873 | 129,285 | 109,199 | Jul 02, 2019, 08:11 PM |
| Neff Thomas B | Chief Executive Officer | Jun 19, 2019 | Option Exercise | $2.90 | 6,834 | 19,819 | 2,449,106 | Jun 21, 2019, 04:47 PM |
| Neff Thomas B | Chief Executive Officer | Jun 20, 2019 | Option Exercise | $2.90 | 6,834 | 19,819 | 2,437,540 | Jun 21, 2019, 04:47 PM |
| Neff Thomas B | Chief Executive Officer | Jun 19, 2019 | Sale | $43.99 | 1,418 | 62,378 | 57,000 | Jun 21, 2019, 04:47 PM |
| Neff Thomas B | Chief Executive Officer | Jun 19, 2019 | Sale | $44.02 | 18,400 | 809,968 | 2,430,706 | Jun 21, 2019, 04:47 PM |
| Neff Thomas B | Chief Executive Officer | Jun 20, 2019 | Sale | $44.32 | 1,418 | 62,840 | 55,682 | Jun 21, 2019, 04:47 PM |
| Neff Thomas B | Chief Executive Officer | Jun 20, 2019 | Sale | $44.39 | 18,400 | 816,820 | 2,421,340 | Jun 21, 2019, 04:47 PM |
| Kouchakji Elias | SVP, Clinical Dev, Drug Safety | Jun 18, 2019 | Option Exercise | $14.57 | 16,000 | 233,200 | 112,072 | Jun 20, 2019, 06:19 PM |
| Cotroneo Pat | SVP, Finance and CFO | Jun 18, 2019 | Sale | $43.12 | 3,201 | 138,027 | 250,777 | Jun 20, 2019, 06:18 PM |
| Chung Christine | SVP, China Operations | Jun 18, 2019 | Option Exercise | $29.66 | 2,120 | 62,879 | 157,195 | Jun 20, 2019, 06:15 PM |
| Chung Christine | SVP, China Operations | Jun 19, 2019 | Option Exercise | $29.66 | 5,625 | 166,837 | 157,195 | Jun 20, 2019, 06:15 PM |
| Chung Christine | SVP, China Operations | Jun 18, 2019 | Sale | $44.08 | 5,625 | 247,950 | 151,570 | Jun 20, 2019, 06:15 PM |
| Chung Christine | SVP, China Operations | Jun 19, 2019 | Sale | $44.02 | 5,625 | 247,613 | 151,570 | Jun 20, 2019, 06:15 PM |
| Yu K Peony | Chief Medical Officer | Jun 12, 2019 | Option Exercise | $14.57 | 10,698 | 155,923 | 190,396 | Jun 14, 2019, 06:55 PM |
| Yu K Peony | Chief Medical Officer | Jun 14, 2019 | Sale | $40.96 | 3,420 | 140,083 | 186,976 | Jun 14, 2019, 06:55 PM |
| Yu K Peony | Chief Medical Officer | Jun 06, 2019 | Option Exercise | $38.31 | 3,360 | 128,722 | 179,698 | Jun 07, 2019, 07:39 PM |
| Neff Thomas B | Chief Executive Officer | Jun 06, 2019 | Option Exercise | $38.31 | 8,542 | 327,244 | 2,442,272 | Jun 07, 2019, 07:38 PM |
| Neff Thomas B | Chief Executive Officer | Jun 06, 2019 | Option Exercise | $2.90 | 6,834 | 19,819 | 2,469,214 | Jun 07, 2019, 07:38 PM |
| Neff Thomas B | Chief Executive Officer | Jun 05, 2019 | Option Exercise | $2.90 | 6,834 | 19,819 | 2,480,780 | Jun 07, 2019, 07:38 PM |
| Neff Thomas B | Chief Executive Officer | Jun 06, 2019 | Sale | $37.94 | 18,400 | 698,073 | 2,462,314 | Jun 07, 2019, 07:38 PM |
| Neff Thomas B | Chief Executive Officer | Jun 05, 2019 | Sale | $38.52 | 1,418 | 54,621 | 59,836 | Jun 07, 2019, 07:38 PM |
| Neff Thomas B | Chief Executive Officer | Jun 05, 2019 | Sale | $38.47 | 18,400 | 707,934 | 2,463,902 | Jun 07, 2019, 07:38 PM |
| Neff Thomas B | Chief Executive Officer | Jun 06, 2019 | Sale | $37.96 | 1,418 | 53,824 | 59,036 | Jun 07, 2019, 07:38 PM |
| Kouchakji Elias | SVP, Clinical Dev, Drug Safety | Jun 06, 2019 | Option Exercise | $38.31 | 2,058 | 78,842 | 96,072 | Jun 07, 2019, 07:36 PM |
| Cotroneo Pat | SVP, Finance and CFO | Jun 06, 2019 | Option Exercise | $38.31 | 3,144 | 120,447 | 253,978 | Jun 07, 2019, 07:34 PM |
| Chung Christine | SVP, China Operations | Jun 06, 2019 | Option Exercise | $38.31 | 3,480 | 133,319 | 155,075 | Jun 07, 2019, 07:33 PM |
| Kurkijarvi Kalevi | Director | Jun 06, 2019 | Option Exercise | $2.90 | 6,000 | 17,400 | 34,400 | Jun 07, 2019, 07:16 PM |
| Kurkijarvi Kalevi | Director | Jun 06, 2019 | Sale | $37.86 | 6,000 | 227,145 | 31,458 | Jun 07, 2019, 07:16 PM |
| Schoeneck James A | Director | May 28, 2019 | Option Exercise | $3.41 | 14,000 | 47,800 | 17,700 | May 30, 2019, 05:43 PM |
| Neff Thomas B | Chief Executive Officer | May 23, 2019 | Option Exercise | $2.90 | 6,834 | 19,819 | 2,492,346 | May 24, 2019, 07:18 PM |
| Neff Thomas B | Chief Executive Officer | May 22, 2019 | Option Exercise | $2.90 | 6,834 | 19,819 | 2,503,912 | May 24, 2019, 07:18 PM |
| Neff Thomas B | Chief Executive Officer | May 23, 2019 | Sale | $35.01 | 18,400 | 644,275 | 2,475,046 | May 24, 2019, 07:18 PM |
| Neff Thomas B | Chief Executive Officer | May 22, 2019 | Sale | $35.71 | 1,418 | 50,637 | 62,672 | May 24, 2019, 07:18 PM |
| Neff Thomas B | Chief Executive Officer | May 22, 2019 | Sale | $35.73 | 18,400 | 657,432 | 2,485,512 | May 24, 2019, 07:18 PM |
| Neff Thomas B | Chief Executive Officer | May 23, 2019 | Sale | $35.05 | 1,418 | 49,701 | 61,254 | May 24, 2019, 07:18 PM |
| Rosenkranz Roberto Pedro | Director | May 15, 2019 | Option Exercise | $16.49 | 30,000 | 494,730 | 62,700 | May 17, 2019, 04:49 PM |
| Neff Thomas B | Chief Executive Officer | May 14, 2019 | Option Exercise | $2.90 | 6,834 | 19,819 | 2,515,478 | May 15, 2019, 07:50 PM |
| Neff Thomas B | Chief Executive Officer | May 13, 2019 | Option Exercise | $2.90 | 6,834 | 19,819 | 2,527,044 | May 15, 2019, 07:50 PM |
| Neff Thomas B | Chief Executive Officer | May 14, 2019 | Sale | $36.90 | 1,418 | 52,331 | 64,408 | May 15, 2019, 07:50 PM |
| Neff Thomas B | Chief Executive Officer | May 14, 2019 | Sale | $36.87 | 18,400 | 678,436 | 2,509,128 | May 15, 2019, 07:50 PM |
| Neff Thomas B | Chief Executive Officer | May 13, 2019 | Sale | $35.76 | 1,418 | 50,712 | 66,008 | May 15, 2019, 07:50 PM |
| Neff Thomas B | Chief Executive Officer | May 13, 2019 | Sale | $35.82 | 18,400 | 659,075 | 2,520,844 | May 15, 2019, 07:50 PM |
| Kurkijarvi Kalevi | Director | May 08, 2019 | Option Exercise | $2.90 | 6,000 | 17,400 | 29,700 | May 10, 2019, 06:07 PM |
| Kurkijarvi Kalevi | Director | May 08, 2019 | Sale | $45.94 | 6,000 | 275,622 | 24,644 | May 10, 2019, 06:07 PM |
| Chung Christine | SVP, China Operations | May 08, 2019 | Option Exercise | $29.66 | 5,625 | 166,837 | 163,562 | May 09, 2019, 09:08 PM |
| Chung Christine | SVP, China Operations | May 07, 2019 | Option Exercise | $29.66 | 5,625 | 166,837 | 163,562 | May 09, 2019, 09:08 PM |
| Chung Christine | SVP, China Operations | May 08, 2019 | Sale | $46.31 | 5,625 | 260,505 | 159,437 | May 09, 2019, 09:08 PM |
| Chung Christine | SVP, China Operations | May 07, 2019 | Sale | $46.50 | 5,625 | 261,565 | 161,637 | May 09, 2019, 09:08 PM |
| Schoeneck James A | Director | May 07, 2019 | Option Exercise | $2.90 | 2,000 | 5,800 | 5,700 | May 09, 2019, 09:00 PM |
| Schoeneck James A | Director | May 07, 2019 | Sale | $47.02 | 2,000 | 94,045 | 4,200 | May 09, 2019, 09:00 PM |
| Cotroneo Pat | SVP, Finance and CFO | May 06, 2019 | Option Exercise | $2.90 | 7,000 | 20,300 | 256,504 | May 08, 2019, 06:45 PM |
| Neff Thomas B | Chief Executive Officer | Apr 17, 2019 | Option Exercise | $2.90 | 6,834 | 19,819 | 2,550,176 | Apr 19, 2019, 05:07 PM |
| Neff Thomas B | Chief Executive Officer | Apr 18, 2019 | Option Exercise | $2.90 | 6,834 | 19,819 | 2,538,610 | Apr 19, 2019, 05:07 PM |
| Neff Thomas B | Chief Executive Officer | Apr 18, 2019 | Sale | $46.88 | 1,418 | 66,470 | 68,144 | Apr 19, 2019, 05:07 PM |
| Neff Thomas B | Chief Executive Officer | Apr 18, 2019 | Sale | $46.81 | 18,400 | 861,263 | 2,535,393 | Apr 19, 2019, 05:07 PM |
| Neff Thomas B | Chief Executive Officer | Apr 17, 2019 | Sale | $46.63 | 1,418 | 66,128 | 68,444 | Apr 19, 2019, 05:07 PM |
| Neff Thomas B | Chief Executive Officer | Apr 17, 2019 | Sale | $46.72 | 18,400 | 859,629 | 2,535,340 | Apr 19, 2019, 05:07 PM |
| Kurkijarvi Kalevi | Director | Apr 15, 2019 | Option Exercise | $2.90 | 4,000 | 11,600 | 27,700 | Apr 17, 2019, 08:19 PM |
| Kurkijarvi Kalevi | Director | Apr 15, 2019 | Sale | $48.09 | 4,000 | 192,360 | 23,700 | Apr 17, 2019, 08:19 PM |
| Cotroneo Pat | SVP, Finance and CFO | Apr 15, 2019 | Option Exercise | $2.90 | 10,000 | 29,000 | 249,504 | Apr 17, 2019, 08:18 PM |
| Schoeneck James A | Director | Apr 08, 2019 | Option Exercise | $2.90 | 2,000 | 5,800 | 29,700 | Apr 10, 2019, 07:43 PM |
| Schoeneck James A | Director | Apr 08, 2019 | Sale | $52.90 | 2,000 | 105,800 | 27,700 | Apr 10, 2019, 07:43 PM |
| Kurkijarvi Kalevi | Director | Apr 08, 2019 | Option Exercise | $2.90 | 4,000 | 11,600 | 27,700 | Apr 10, 2019, 07:41 PM |
| Kurkijarvi Kalevi | Director | Apr 08, 2019 | Sale | $53.03 | 4,000 | 212,121 | 24,273 | Apr 10, 2019, 07:41 PM |
| Neff Thomas B | Chief Executive Officer | Apr 03, 2019 | Option Exercise | $2.90 | 6,834 | 19,819 | 2,573,308 | Apr 05, 2019, 06:54 PM |
| Neff Thomas B | Chief Executive Officer | Apr 04, 2019 | Option Exercise | $2.90 | 6,834 | 19,819 | 2,561,742 | Apr 05, 2019, 06:54 PM |
| Neff Thomas B | Chief Executive Officer | Apr 04, 2019 | Sale | $53.38 | 1,418 | 75,695 | 70,062 | Apr 05, 2019, 06:54 PM |
| Neff Thomas B | Chief Executive Officer | Apr 04, 2019 | Sale | $53.52 | 18,400 | 984,763 | 2,547,842 | Apr 05, 2019, 06:54 PM |
| Neff Thomas B | Chief Executive Officer | Apr 03, 2019 | Sale | $54.60 | 1,418 | 77,423 | 71,180 | Apr 05, 2019, 06:54 PM |
| Neff Thomas B | Chief Executive Officer | Apr 03, 2019 | Sale | $54.64 | 18,400 | 1,005,314 | 2,555,108 | Apr 05, 2019, 06:54 PM |
| Routti Jorma | Director | Mar 26, 2019 | Option Exercise | $22.75 | 30,000 | 682,440 | 161,540 | Mar 27, 2019, 06:27 PM |
| Neff Thomas B | Chief Executive Officer | Mar 20, 2019 | Option Exercise | $2.90 | 6,834 | 19,819 | 2,596,440 | Mar 22, 2019, 05:37 PM |
| Neff Thomas B | Chief Executive Officer | Mar 21, 2019 | Option Exercise | $2.90 | 6,834 | 19,819 | 2,584,874 | Mar 22, 2019, 05:37 PM |
| Neff Thomas B | Chief Executive Officer | Mar 21, 2019 | Sale | $55.83 | 1,418 | 79,167 | 72,598 | Mar 22, 2019, 05:37 PM |
| Neff Thomas B | Chief Executive Officer | Mar 21, 2019 | Sale | $55.60 | 18,400 | 1,023,012 | 2,575,232 | Mar 22, 2019, 05:37 PM |
| Neff Thomas B | Chief Executive Officer | Mar 20, 2019 | Sale | $55.61 | 1,418 | 78,850 | 75,006 | Mar 22, 2019, 05:37 PM |
| Neff Thomas B | Chief Executive Officer | Mar 20, 2019 | Sale | $55.41 | 18,400 | 1,019,590 | 2,585,306 | Mar 22, 2019, 05:37 PM |
| Cotroneo Pat | SVP, Finance and CFO | Mar 19, 2019 | Sale | $55.41 | 7,665 | 424,718 | 239,504 | Mar 20, 2019, 06:47 PM |
| Yu K Peony | Chief Medical Officer | Mar 14, 2019 | Sale | $56.30 | 9,145 | 514,863 | 182,440 | Mar 15, 2019, 06:11 PM |
| Schoeneck James A | Director | Mar 07, 2019 | Option Exercise | $2.90 | 2,000 | 5,800 | 29,700 | Mar 08, 2019, 06:47 PM |
| Schoeneck James A | Director | Mar 07, 2019 | Sale | $54.74 | 2,000 | 109,472 | 28,080 | Mar 08, 2019, 06:47 PM |
| Neff Thomas B | Chief Executive Officer | Mar 07, 2019 | Option Exercise | $2.90 | 6,834 | 19,819 | 2,608,006 | Mar 08, 2019, 06:41 PM |
| Neff Thomas B | Chief Executive Officer | Mar 06, 2019 | Option Exercise | $2.90 | 6,834 | 19,819 | 2,619,572 | Mar 08, 2019, 06:41 PM |
| Neff Thomas B | Chief Executive Officer | Mar 07, 2019 | Sale | $54.94 | 18,400 | 1,010,844 | 2,590,806 | Mar 08, 2019, 06:41 PM |
| Neff Thomas B | Chief Executive Officer | Mar 06, 2019 | Sale | $56.25 | 1,418 | 79,769 | 77,452 | Mar 08, 2019, 06:41 PM |
| Neff Thomas B | Chief Executive Officer | Mar 06, 2019 | Sale | $56.38 | 18,400 | 1,037,316 | 2,610,108 | Mar 08, 2019, 06:41 PM |
| Neff Thomas B | Chief Executive Officer | Mar 07, 2019 | Sale | $54.93 | 1,418 | 77,890 | 75,534 | Mar 08, 2019, 06:41 PM |
| Yu K Peony | Chief Medical Officer | Mar 04, 2019 | Option Exercise | $58.69 | 693 | 40,672 | 196,530 | Mar 06, 2019, 07:10 PM |
| Yu K Peony | Chief Medical Officer | Mar 06, 2019 | Option Exercise | $55.58 | 4,945 | 274,843 | 191,585 | Mar 06, 2019, 07:10 PM |
| Neff Thomas B | Chief Executive Officer | Mar 06, 2019 | Option Exercise | $55.58 | 15,049 | 836,423 | 2,612,738 | Mar 06, 2019, 07:08 PM |
| Neff Thomas B | Chief Executive Officer | Mar 04, 2019 | Option Exercise | $58.69 | 2,288 | 134,283 | 2,627,787 | Mar 06, 2019, 07:08 PM |
| Cotroneo Pat | SVP, Finance and CFO | Mar 06, 2019 | Option Exercise | $55.58 | 5,242 | 291,350 | 247,169 | Mar 06, 2019, 07:07 PM |
| Cotroneo Pat | SVP, Finance and CFO | Mar 04, 2019 | Option Exercise | $58.69 | 693 | 40,672 | 252,411 | Mar 06, 2019, 07:07 PM |
| Cotroneo Pat | SVP, Finance and CFO | Feb 28, 2019 | Option Exercise | $29.66 | 14,787 | 438,582 | 267,891 | Mar 01, 2019, 06:05 PM |
| Cotroneo Pat | SVP, Finance and CFO | Feb 28, 2019 | Sale | $60.08 | 14,787 | 888,391 | 253,104 | Mar 01, 2019, 06:05 PM |
| Neff Thomas B | Chief Executive Officer | Feb 20, 2019 | Option Exercise | $3.60 | 10,319 | 37,148 | 2,649,475 | Feb 21, 2019, 07:47 PM |
| Neff Thomas B | Chief Executive Officer | Feb 19, 2019 | Option Exercise | $3.60 | 10,319 | 37,148 | 2,658,056 | Feb 21, 2019, 07:47 PM |
| Neff Thomas B | Chief Executive Officer | Feb 20, 2019 | Sale | $57.06 | 918 | 52,377 | 78,688 | Feb 21, 2019, 07:47 PM |
| Neff Thomas B | Chief Executive Officer | Feb 20, 2019 | Sale | $57.11 | 18,900 | 1,079,305 | 2,640,425 | Feb 21, 2019, 07:47 PM |
| Neff Thomas B | Chief Executive Officer | Feb 19, 2019 | Sale | $57.67 | 918 | 52,941 | 79,188 | Feb 21, 2019, 07:47 PM |
| Neff Thomas B | Chief Executive Officer | Feb 19, 2019 | Sale | $57.71 | 18,900 | 1,090,797 | 2,639,956 | Feb 21, 2019, 07:47 PM |
| Schoeneck James A | Director | Feb 07, 2019 | Option Exercise | $2.90 | 2,000 | 5,800 | 29,700 | Feb 08, 2019, 07:00 PM |
| Schoeneck James A | Director | Feb 07, 2019 | Sale | $57.17 | 2,000 | 114,340 | 27,700 | Feb 08, 2019, 07:00 PM |
| Neff Thomas B | Chief Executive Officer | Feb 08, 2019 | Option Exercise | $3.60 | 10,319 | 37,148 | 2,666,637 | Feb 08, 2019, 06:58 PM |
| Neff Thomas B | Chief Executive Officer | Feb 07, 2019 | Option Exercise | $3.60 | 10,319 | 37,148 | 2,680,346 | Feb 08, 2019, 06:58 PM |
| Neff Thomas B | Chief Executive Officer | Feb 08, 2019 | Sale | $56.89 | 918 | 52,222 | 80,206 | Feb 08, 2019, 06:58 PM |
| Neff Thomas B | Chief Executive Officer | Feb 08, 2019 | Sale | $56.91 | 18,900 | 1,075,595 | 2,661,380 | Feb 08, 2019, 06:58 PM |
| Neff Thomas B | Chief Executive Officer | Feb 07, 2019 | Sale | $56.16 | 28,362 | 1,592,860 | 2,661,331 | Feb 08, 2019, 06:58 PM |
| Neff Thomas B | Chief Executive Officer | Jan 23, 2019 | Option Exercise | $3.60 | 10,319 | 37,148 | 2,604,335 | Jan 24, 2019, 07:32 PM |
| Neff Thomas B | Chief Executive Officer | Jan 22, 2019 | Option Exercise | $3.60 | 10,319 | 37,148 | 2,624,016 | Jan 24, 2019, 07:32 PM |
| Neff Thomas B | Chief Executive Officer | Jan 23, 2019 | Sale | $52.59 | 1,390 | 73,100 | 85,358 | Jan 24, 2019, 07:32 PM |
| Neff Thomas B | Chief Executive Officer | Jan 23, 2019 | Sale | $51.83 | 702 | 36,385 | 86,748 | Jan 24, 2019, 07:32 PM |
| Neff Thomas B | Chief Executive Officer | Jan 23, 2019 | Sale | $51.99 | 27,908 | 1,451,018 | 2,591,487 | Jan 24, 2019, 07:32 PM |
| Neff Thomas B | Chief Executive Officer | Jan 22, 2019 | Sale | $51.99 | 30,000 | 1,559,640 | 2,597,566 | Jan 24, 2019, 07:32 PM |
| Schoeneck James A | Director | Jan 07, 2019 | Option Exercise | $2.90 | 2,000 | 5,800 | 29,700 | Jan 09, 2019, 06:48 PM |
| Schoeneck James A | Director | Jan 07, 2019 | Sale | $45.90 | 2,000 | 91,800 | 27,700 | Jan 09, 2019, 06:48 PM |
| Neff Thomas B | Chief Executive Officer | Jan 04, 2019 | Option Exercise | $3.60 | 20,912 | 75,283 | 2,643,697 | Jan 07, 2019, 07:20 PM |
| Neff Thomas B | Chief Executive Officer | Jan 03, 2019 | Option Exercise | $3.60 | 30,000 | 108,000 | 2,652,785 | Jan 07, 2019, 07:20 PM |
| Neff Thomas B | Chief Executive Officer | Jan 04, 2019 | Sale | $44.91 | 30,000 | 1,347,408 | 2,639,297 | Jan 07, 2019, 07:20 PM |
| Neff Thomas B | Chief Executive Officer | Jan 03, 2019 | Sale | $43.87 | 30,000 | 1,316,072 | 2,640,885 | Jan 07, 2019, 07:20 PM |
| Rosenkranz Roberto Pedro | Director | Dec 20, 2018 | Option Exercise | $9.77 | 1,000 | 9,775 | 33,700 | Dec 21, 2018, 04:22 PM |
| Rosenkranz Roberto Pedro | Director | Dec 20, 2018 | Sale | $41.00 | 1,000 | 41,000 | 32,700 | Dec 21, 2018, 04:22 PM |
| Kurkijarvi Kalevi | Director | Dec 19, 2018 | Option Exercise | $2.90 | 4,000 | 11,600 | 27,700 | Dec 21, 2018, 04:20 PM |
| Kurkijarvi Kalevi | Director | Dec 19, 2018 | Sale | $41.32 | 4,000 | 165,288 | 26,300 | Dec 21, 2018, 04:20 PM |
| Cotroneo Pat | SVP, Finance and CFO | Dec 18, 2018 | Sale | $41.10 | 3,330 | 136,863 | 222,004 | Dec 20, 2018, 08:34 PM |
| Yu K Peony | Chief Medical Officer | Dec 14, 2018 | Sale | $38.58 | 3,422 | 132,021 | 144,123 | Dec 18, 2018, 08:05 PM |
| Neff Thomas B | Chief Executive Officer | Dec 06, 2018 | Option Exercise | $40.93 | 6,373 | 260,847 | 2,639,947 | Dec 06, 2018, 08:45 PM |
| Neff Thomas B | Chief Executive Officer | Dec 03, 2018 | Option Exercise | $43.93 | 2,287 | 100,468 | 2,646,320 | Dec 06, 2018, 08:45 PM |
| Neff Thomas B | Chief Executive Officer | Dec 06, 2018 | Option Exercise | $3.60 | 11,002 | 39,607 | 2,650,949 | Dec 06, 2018, 08:45 PM |
| Neff Thomas B | Chief Executive Officer | Dec 06, 2018 | Sale | $40.91 | 1,836 | 75,111 | 87,450 | Dec 06, 2018, 08:45 PM |
| Neff Thomas B | Chief Executive Officer | Dec 06, 2018 | Sale | $40.93 | 28,164 | 1,152,666 | 2,632,012 | Dec 06, 2018, 08:45 PM |
| Yu K Peony | Chief Medical Officer | Dec 06, 2018 | Option Exercise | $40.93 | 2,369 | 96,963 | 147,545 | Dec 06, 2018, 08:42 PM |
| Yu K Peony | Chief Medical Officer | Dec 03, 2018 | Option Exercise | $43.93 | 993 | 43,622 | 149,914 | Dec 06, 2018, 08:42 PM |
| Cotroneo Pat | SVP, Finance and CFO | Dec 03, 2018 | Option Exercise | $43.93 | 993 | 43,622 | 227,611 | Dec 06, 2018, 08:40 PM |
| Cotroneo Pat | SVP, Finance and CFO | Dec 06, 2018 | Option Exercise | $40.93 | 2,277 | 93,198 | 225,334 | Dec 06, 2018, 08:40 PM |
| Neff Thomas B | Chief Executive Officer | Nov 20, 2018 | Option Exercise | $3.60 | 10,319 | 37,148 | 2,676,088 | Nov 21, 2018, 06:23 PM |
| Neff Thomas B | Chief Executive Officer | Nov 21, 2018 | Option Exercise | $3.60 | 10,319 | 37,148 | 2,667,507 | Nov 21, 2018, 06:23 PM |
| Neff Thomas B | Chief Executive Officer | Nov 21, 2018 | Sale | $39.47 | 918 | 36,233 | 89,286 | Nov 21, 2018, 06:23 PM |
| Neff Thomas B | Chief Executive Officer | Nov 21, 2018 | Sale | $39.47 | 18,900 | 745,983 | 2,648,607 | Nov 21, 2018, 06:23 PM |
| Neff Thomas B | Chief Executive Officer | Nov 20, 2018 | Sale | $39.25 | 918 | 36,031 | 90,304 | Nov 21, 2018, 06:23 PM |
| Neff Thomas B | Chief Executive Officer | Nov 20, 2018 | Sale | $39.26 | 18,900 | 742,041 | 2,673,388 | Nov 21, 2018, 06:23 PM |
| Rosenkranz Roberto Pedro | Director | Nov 15, 2018 | Option Exercise | $9.77 | 1,000 | 9,775 | 33,700 | Nov 16, 2018, 06:28 PM |
| Rosenkranz Roberto Pedro | Director | Nov 15, 2018 | Sale | $39.24 | 1,000 | 39,240 | 32,700 | Nov 16, 2018, 06:28 PM |
| Kurkijarvi Kalevi | Director | Nov 15, 2018 | Option Exercise | $2.90 | 4,000 | 11,600 | 27,700 | Nov 16, 2018, 06:24 PM |
| Kurkijarvi Kalevi | Director | Nov 15, 2018 | Sale | $39.77 | 4,000 | 159,094 | 24,300 | Nov 16, 2018, 06:24 PM |
| Neff Thomas B | Chief Executive Officer | Nov 02, 2018 | Option Exercise | $3.60 | 10,319 | 37,148 | 2,684,669 | Nov 02, 2018, 06:40 PM |
| Neff Thomas B | Chief Executive Officer | Nov 01, 2018 | Option Exercise | $3.60 | 10,319 | 37,148 | 2,693,250 | Nov 02, 2018, 06:40 PM |
| Neff Thomas B | Chief Executive Officer | Nov 01, 2018 | Sale | $44.08 | 918 | 40,465 | 92,040 | Nov 02, 2018, 06:40 PM |
| Neff Thomas B | Chief Executive Officer | Nov 01, 2018 | Sale | $44.04 | 18,900 | 832,338 | 2,678,850 | Nov 02, 2018, 06:40 PM |
| Neff Thomas B | Chief Executive Officer | Nov 02, 2018 | Sale | $44.61 | 918 | 40,952 | 91,122 | Nov 02, 2018, 06:40 PM |
| Neff Thomas B | Chief Executive Officer | Nov 02, 2018 | Sale | $44.60 | 18,900 | 842,866 | 2,666,869 | Nov 02, 2018, 06:40 PM |
| Schoeneck James A | Director | Oct 30, 2018 | Option Exercise | $13.89 | 24,000 | 333,300 | 27,700 | Nov 01, 2018, 01:48 PM |
| Rosenkranz Roberto Pedro | Director | Oct 18, 2018 | Option Exercise | $9.77 | 1,000 | 9,775 | 33,700 | Oct 19, 2018, 08:41 PM |
| Rosenkranz Roberto Pedro | Director | Oct 18, 2018 | Sale | $55.39 | 1,000 | 55,387 | 33,636 | Oct 19, 2018, 08:41 PM |
| Kurkijarvi Kalevi | Director | Oct 18, 2018 | Option Exercise | $2.90 | 4,000 | 11,600 | 27,700 | Oct 19, 2018, 08:40 PM |
| Kurkijarvi Kalevi | Director | Oct 18, 2018 | Sale | $55.42 | 4,000 | 221,670 | 27,450 | Oct 19, 2018, 08:40 PM |
| Neff Thomas B | Chief Executive Officer | Oct 19, 2018 | Option Exercise | $3.60 | 10,319 | 37,148 | 2,701,831 | Oct 19, 2018, 08:37 PM |
| Neff Thomas B | Chief Executive Officer | Oct 18, 2018 | Option Exercise | $3.60 | 10,319 | 37,148 | 2,710,412 | Oct 19, 2018, 08:37 PM |
| Neff Thomas B | Chief Executive Officer | Oct 19, 2018 | Sale | $53.69 | 918 | 49,285 | 93,258 | Oct 19, 2018, 08:37 PM |
| Neff Thomas B | Chief Executive Officer | Oct 19, 2018 | Sale | $53.92 | 18,900 | 1,019,110 | 2,695,731 | Oct 19, 2018, 08:37 PM |
| Neff Thomas B | Chief Executive Officer | Oct 18, 2018 | Sale | $54.56 | 918 | 50,088 | 94,076 | Oct 19, 2018, 08:37 PM |
| Neff Thomas B | Chief Executive Officer | Oct 18, 2018 | Sale | $54.52 | 18,900 | 1,030,443 | 2,697,276 | Oct 19, 2018, 08:37 PM |
| Neff Thomas B | Chief Executive Officer | Oct 02, 2018 | Option Exercise | $3.60 | 10,320 | 37,152 | 2,727,574 | Oct 04, 2018, 06:00 PM |
| Neff Thomas B | Chief Executive Officer | Oct 03, 2018 | Option Exercise | $3.60 | 10,319 | 37,148 | 2,718,993 | Oct 04, 2018, 06:00 PM |
| Neff Thomas B | Chief Executive Officer | Oct 02, 2018 | Sale | $58.83 | 18,900 | 1,111,915 | 2,718,576 | Oct 04, 2018, 06:00 PM |
| Neff Thomas B | Chief Executive Officer | Oct 03, 2018 | Sale | $59.49 | 918 | 54,608 | 95,405 | Oct 04, 2018, 06:00 PM |
| Neff Thomas B | Chief Executive Officer | Oct 03, 2018 | Sale | $59.45 | 18,900 | 1,123,690 | 2,710,800 | Oct 04, 2018, 06:00 PM |
| Neff Thomas B | Chief Executive Officer | Oct 02, 2018 | Sale | $58.92 | 918 | 54,085 | 95,912 | Oct 04, 2018, 06:00 PM |
| Rosenkranz Roberto Pedro | Director | Sep 20, 2018 | Option Exercise | $9.77 | 1,000 | 9,775 | 33,700 | Sep 21, 2018, 06:16 PM |
| Rosenkranz Roberto Pedro | Director | Sep 20, 2018 | Sale | $56.95 | 1,000 | 56,950 | 32,700 | Sep 21, 2018, 06:16 PM |
| Neff Thomas B | Chief Executive Officer | Sep 19, 2018 | Option Exercise | $3.60 | 10,320 | 37,152 | 2,744,734 | Sep 21, 2018, 06:15 PM |
| Neff Thomas B | Chief Executive Officer | Sep 20, 2018 | Option Exercise | $3.60 | 10,320 | 37,152 | 2,736,154 | Sep 21, 2018, 06:15 PM |
| Neff Thomas B | Chief Executive Officer | Sep 19, 2018 | Sale | $56.87 | 18,900 | 1,074,772 | 2,733,326 | Sep 21, 2018, 06:15 PM |
| Neff Thomas B | Chief Executive Officer | Sep 20, 2018 | Sale | $58.87 | 918 | 54,041 | 97,539 | Sep 21, 2018, 06:15 PM |
| Neff Thomas B | Chief Executive Officer | Sep 20, 2018 | Sale | $58.74 | 18,900 | 1,110,165 | 2,734,863 | Sep 21, 2018, 06:15 PM |
| Neff Thomas B | Chief Executive Officer | Sep 19, 2018 | Sale | $56.88 | 918 | 52,220 | 97,756 | Sep 21, 2018, 06:15 PM |
| Kurkijarvi Kalevi | Director | Sep 17, 2018 | Option Exercise | $2.90 | 4,000 | 11,600 | 27,700 | Sep 18, 2018, 06:16 PM |
| Kurkijarvi Kalevi | Director | Sep 17, 2018 | Sale | $58.86 | 4,000 | 235,456 | 24,900 | Sep 18, 2018, 06:16 PM |
| Cotroneo Pat | SVP, Finance and CFO | Sep 12, 2018 | Option Exercise | $2.90 | 10,500 | 30,450 | 230,922 | Sep 14, 2018, 05:19 PM |
| Cotroneo Pat | SVP, Finance and CFO | Sep 13, 2018 | Sale | $59.50 | 2,318 | 137,921 | 228,604 | Sep 14, 2018, 05:19 PM |
| Routti Jorma | Director | Sep 10, 2018 | Option Exercise | $18.34 | 6,000 | 110,040 | 137,540 | Sep 12, 2018, 12:00 AM |
| Cotroneo Pat | SVP, Finance and CFO | Sep 10, 2018 | Sale | $57.35 | 1,011 | 57,981 | 220,422 | Sep 12, 2018, 12:00 AM |
| Routti Jorma | Director | Sep 10, 2018 | Sale | $57.31 | 6,000 | 343,837 | 133,240 | Sep 12, 2018, 12:00 AM |
| Neff Thomas B | Chief Executive Officer | Sep 07, 2018 | Option Exercise | $3.60 | 10,320 | 37,152 | 2,753,314 | Sep 07, 2018, 06:28 PM |
| Neff Thomas B | Chief Executive Officer | Sep 06, 2018 | Option Exercise | $3.60 | 10,320 | 37,152 | 2,761,894 | Sep 07, 2018, 06:28 PM |
| Neff Thomas B | Chief Executive Officer | Sep 06, 2018 | Sale | $57.97 | 918 | 53,216 | 99,584 | Sep 07, 2018, 06:28 PM |
| Neff Thomas B | Chief Executive Officer | Sep 06, 2018 | Sale | $58.29 | 18,900 | 1,101,599 | 2,749,414 | Sep 07, 2018, 06:28 PM |
| Neff Thomas B | Chief Executive Officer | Sep 07, 2018 | Sale | $56.74 | 918 | 52,084 | 98,666 | Sep 07, 2018, 06:28 PM |
| Neff Thomas B | Chief Executive Officer | Sep 07, 2018 | Sale | $56.75 | 18,900 | 1,072,600 | 2,737,819 | Sep 07, 2018, 06:28 PM |
| Yu K Peony | Chief Medical Officer | Sep 06, 2018 | Option Exercise | $57.30 | 2,368 | 135,686 | 150,907 | Sep 06, 2018, 08:52 PM |
| Neff Thomas B | Chief Executive Officer | Sep 06, 2018 | Option Exercise | $57.30 | 6,373 | 365,173 | 2,751,574 | Sep 06, 2018, 08:49 PM |
| Neff Thomas B | Chief Executive Officer | Sep 04, 2018 | Option Exercise | $61.05 | 2,286 | 139,560 | 2,757,947 | Sep 06, 2018, 08:49 PM |
| Cotroneo Pat | SVP, Finance and CFO | Sep 06, 2018 | Option Exercise | $57.30 | 2,277 | 130,472 | 221,433 | Sep 06, 2018, 08:33 PM |
| Cotroneo Pat | SVP, Finance and CFO | Sep 04, 2018 | Option Exercise | $61.05 | 994 | 60,684 | 223,710 | Sep 06, 2018, 08:33 PM |
| Yu K Peony | Chief Medical Officer | Sep 04, 2018 | Option Exercise | $61.05 | 994 | 60,684 | 153,275 | Sep 05, 2018, 06:37 PM |
| Yu K Peony | Chief Medical Officer | Aug 31, 2018 | Option Exercise | $12.29 | 6,800 | 83,585 | 154,269 | Sep 05, 2018, 06:37 PM |
| Tamura Toshinari | Director | Aug 22, 2018 | Option Exercise | $19.05 | 12,000 | 228,600 | 63,700 | Aug 24, 2018, 07:25 PM |
| Tamura Toshinari | Director | Aug 22, 2018 | Sale | $60.65 | 12,000 | 727,800 | 51,700 | Aug 24, 2018, 07:25 PM |
| Neff Thomas B | Chief Executive Officer | Aug 21, 2018 | Option Exercise | $3.60 | 10,320 | 37,152 | 2,779,133 | Aug 22, 2018, 07:25 PM |
| Neff Thomas B | Chief Executive Officer | Aug 20, 2018 | Option Exercise | $3.60 | 10,320 | 37,152 | 2,787,713 | Aug 22, 2018, 07:25 PM |
| Neff Thomas B | Chief Executive Officer | Aug 21, 2018 | Sale | $60.55 | 18,900 | 1,144,320 | 2,774,768 | Aug 22, 2018, 07:25 PM |
| Neff Thomas B | Chief Executive Officer | Aug 20, 2018 | Sale | $59.82 | 918 | 54,915 | 101,220 | Aug 22, 2018, 07:25 PM |
| Neff Thomas B | Chief Executive Officer | Aug 20, 2018 | Sale | $59.94 | 18,900 | 1,132,909 | 2,772,816 | Aug 22, 2018, 07:25 PM |
| Neff Thomas B | Chief Executive Officer | Aug 21, 2018 | Sale | $60.59 | 918 | 55,622 | 100,302 | Aug 22, 2018, 07:25 PM |
| Rosenkranz Roberto Pedro | Director | Aug 16, 2018 | Option Exercise | $9.77 | 1,000 | 9,775 | 33,700 | Aug 17, 2018, 05:28 PM |
| Rosenkranz Roberto Pedro | Director | Aug 16, 2018 | Sale | $60.28 | 1,000 | 60,279 | 33,280 | Aug 17, 2018, 05:28 PM |
| Kurkijarvi Kalevi | Director | Aug 16, 2018 | Option Exercise | $2.90 | 4,000 | 11,600 | 27,700 | Aug 17, 2018, 05:25 PM |
| Kurkijarvi Kalevi | Director | Aug 16, 2018 | Sale | $60.28 | 4,000 | 241,128 | 26,150 | Aug 17, 2018, 05:25 PM |
| Routti Jorma | Director | Aug 09, 2018 | Option Exercise | $18.00 | 6,000 | 108,000 | 137,540 | Aug 10, 2018, 04:48 PM |
| Routti Jorma | Director | Aug 09, 2018 | Sale | $59.93 | 6,000 | 359,579 | 133,840 | Aug 10, 2018, 04:48 PM |
| Neff Thomas B | Chief Executive Officer | Aug 02, 2018 | Option Exercise | $3.60 | 10,320 | 37,152 | 2,796,293 | Aug 03, 2018, 04:58 PM |
| Neff Thomas B | Chief Executive Officer | Aug 01, 2018 | Option Exercise | $3.60 | 10,320 | 37,152 | 2,804,873 | Aug 03, 2018, 04:58 PM |
| Neff Thomas B | Chief Executive Officer | Aug 01, 2018 | Sale | $63.08 | 918 | 57,907 | 103,056 | Aug 03, 2018, 04:58 PM |
| Neff Thomas B | Chief Executive Officer | Aug 01, 2018 | Sale | $63.11 | 18,900 | 1,192,847 | 2,791,213 | Aug 03, 2018, 04:58 PM |
| Neff Thomas B | Chief Executive Officer | Aug 02, 2018 | Sale | $62.88 | 918 | 57,724 | 102,138 | Aug 03, 2018, 04:58 PM |
| Neff Thomas B | Chief Executive Officer | Aug 02, 2018 | Sale | $62.90 | 18,900 | 1,188,723 | 2,784,693 | Aug 03, 2018, 04:58 PM |
| Rosenkranz Roberto Pedro | Director | Jul 19, 2018 | Option Exercise | $9.77 | 1,000 | 9,775 | 33,700 | Jul 20, 2018, 06:10 PM |
| Rosenkranz Roberto Pedro | Director | Jul 19, 2018 | Sale | $64.90 | 1,000 | 64,900 | 32,700 | Jul 20, 2018, 06:10 PM |
| Neff Thomas B | Chief Executive Officer | Jul 19, 2018 | Option Exercise | $3.60 | 10,320 | 37,152 | 2,813,453 | Jul 20, 2018, 06:08 PM |
| Neff Thomas B | Chief Executive Officer | Jul 18, 2018 | Option Exercise | $3.60 | 10,320 | 37,152 | 2,822,033 | Jul 20, 2018, 06:08 PM |
| Neff Thomas B | Chief Executive Officer | Jul 19, 2018 | Sale | $64.27 | 918 | 59,000 | 103,974 | Jul 20, 2018, 06:08 PM |
| Neff Thomas B | Chief Executive Officer | Jul 19, 2018 | Sale | $64.34 | 18,900 | 1,216,072 | 2,794,653 | Jul 20, 2018, 06:08 PM |
| Neff Thomas B | Chief Executive Officer | Jul 18, 2018 | Sale | $65.48 | 918 | 60,111 | 104,892 | Jul 20, 2018, 06:08 PM |
| Neff Thomas B | Chief Executive Officer | Jul 18, 2018 | Sale | $65.48 | 18,900 | 1,237,599 | 2,813,933 | Jul 20, 2018, 06:08 PM |
| Kurkijarvi Kalevi | Director | Jul 19, 2018 | Option Exercise | $2.90 | 4,000 | 11,600 | 27,700 | Jul 20, 2018, 06:07 PM |
| Kurkijarvi Kalevi | Director | Jul 19, 2018 | Sale | $64.35 | 4,000 | 257,400 | 23,700 | Jul 20, 2018, 06:07 PM |
| Routti Jorma | Director | Jul 09, 2018 | Option Exercise | $18.00 | 6,000 | 108,000 | 137,540 | Jul 11, 2018, 06:59 PM |
| Routti Jorma | Director | Jul 09, 2018 | Sale | $67.71 | 6,000 | 406,260 | 131,540 | Jul 11, 2018, 06:59 PM |
| Yu K Peony | Chief Medical Officer | Jul 03, 2018 | Option Exercise | $14.57 | 15,645 | 228,026 | 163,114 | Jul 06, 2018, 08:06 PM |
| Yu K Peony | Chief Medical Officer | Jul 03, 2018 | Sale | $65.00 | 15,645 | 1,016,925 | 147,469 | Jul 06, 2018, 08:06 PM |
| Schoeneck James A | Director | Jul 03, 2018 | Option Exercise | $2.90 | 7,639 | 22,153 | 11,339 | Jul 06, 2018, 08:04 PM |
| Schoeneck James A | Director | Jul 03, 2018 | Sale | $65.00 | 7,639 | 496,535 | 3,700 | Jul 06, 2018, 08:04 PM |
| Neff Thomas B | Chief Executive Officer | Jul 05, 2018 | Option Exercise | $3.60 | 10,320 | 37,152 | 2,839,193 | Jul 06, 2018, 08:02 PM |
| Neff Thomas B | Chief Executive Officer | Jul 06, 2018 | Option Exercise | $3.60 | 10,320 | 37,152 | 2,830,613 | Jul 06, 2018, 08:02 PM |
| Neff Thomas B | Chief Executive Officer | Jul 06, 2018 | Sale | $66.02 | 918 | 60,608 | 106,128 | Jul 06, 2018, 08:02 PM |
| Neff Thomas B | Chief Executive Officer | Jul 06, 2018 | Sale | $65.81 | 18,900 | 1,243,853 | 2,829,013 | Jul 06, 2018, 08:02 PM |
| Neff Thomas B | Chief Executive Officer | Jul 05, 2018 | Sale | $64.01 | 918 | 58,762 | 106,828 | Jul 06, 2018, 08:02 PM |
| Neff Thomas B | Chief Executive Officer | Jul 05, 2018 | Sale | $64.16 | 18,900 | 1,212,543 | 2,825,693 | Jul 06, 2018, 08:02 PM |
| Schoeneck James A | Director | Jun 22, 2018 | Option Exercise | $2.90 | 4,361 | 12,647 | 8,061 | Jun 26, 2018, 08:02 PM |
| Schoeneck James A | Director | Jun 22, 2018 | Sale | $65.00 | 4,361 | 283,465 | 3,700 | Jun 26, 2018, 08:02 PM |
| Rosenkranz Roberto Pedro | Director | Jun 21, 2018 | Option Exercise | $9.77 | 1,000 | 9,775 | 33,700 | Jun 22, 2018, 05:48 PM |
| Rosenkranz Roberto Pedro | Director | Jun 21, 2018 | Sale | $63.65 | 1,000 | 63,650 | 32,700 | Jun 22, 2018, 05:48 PM |
| Neff Thomas B | Chief Executive Officer | Jun 21, 2018 | Option Exercise | $3.60 | 10,320 | 37,152 | 2,847,773 | Jun 22, 2018, 05:46 PM |
| Neff Thomas B | Chief Executive Officer | Jun 20, 2018 | Option Exercise | $3.60 | 10,320 | 37,152 | 2,856,353 | Jun 22, 2018, 05:46 PM |
| Neff Thomas B | Chief Executive Officer | Jun 20, 2018 | Sale | $63.60 | 918 | 58,389 | 108,684 | Jun 22, 2018, 05:46 PM |
| Neff Thomas B | Chief Executive Officer | Jun 20, 2018 | Sale | $63.59 | 18,900 | 1,201,935 | 2,848,652 | Jun 22, 2018, 05:46 PM |
| Neff Thomas B | Chief Executive Officer | Jun 21, 2018 | Sale | $63.60 | 918 | 58,385 | 107,646 | Jun 22, 2018, 05:46 PM |
| Neff Thomas B | Chief Executive Officer | Jun 21, 2018 | Sale | $63.65 | 18,900 | 1,202,919 | 2,832,601 | Jun 22, 2018, 05:46 PM |
| Kurkijarvi Kalevi | Director | Jun 18, 2018 | Option Exercise | $2.90 | 4,000 | 11,600 | 27,700 | Jun 20, 2018, 06:47 PM |
| Kurkijarvi Kalevi | Director | Jun 18, 2018 | Sale | $58.19 | 4,000 | 232,760 | 23,700 | Jun 20, 2018, 06:47 PM |
| Yu K Peony | Chief Medical Officer | Jun 14, 2018 | Sale | $59.20 | 3,422 | 202,582 | 147,469 | Jun 15, 2018, 04:48 PM |
| Cotroneo Pat | SVP, Finance and CFO | Jun 14, 2018 | Option Exercise | $25.40 | 7,750 | 196,850 | 232,454 | Jun 15, 2018, 04:46 PM |
| Cotroneo Pat | SVP, Finance and CFO | Jun 14, 2018 | Sale | $60.00 | 7,750 | 465,000 | 224,704 | Jun 15, 2018, 04:46 PM |
| Cotroneo Pat | SVP, Finance and CFO | Jun 13, 2018 | Sale | $57.70 | 2,319 | 133,806 | 224,704 | Jun 15, 2018, 04:46 PM |
| Routti Jorma | Director | Jun 11, 2018 | Option Exercise | $9.77 | 6,000 | 58,650 | 137,540 | Jun 12, 2018, 07:56 PM |
| Routti Jorma | Director | Jun 11, 2018 | Sale | $57.48 | 6,000 | 344,880 | 131,540 | Jun 12, 2018, 07:56 PM |
| Yu K Peony | Chief Medical Officer | Jun 06, 2018 | Option Exercise | $56.60 | 2,369 | 134,085 | 150,891 | Jun 08, 2018, 07:22 PM |
| Neff Thomas B | Chief Executive Officer | Jun 06, 2018 | Option Exercise | $56.60 | 6,373 | 360,712 | 2,846,033 | Jun 08, 2018, 07:20 PM |
| Cotroneo Pat | SVP, Finance and CFO | Jun 06, 2018 | Option Exercise | $56.60 | 2,277 | 128,878 | 228,034 | Jun 08, 2018, 07:18 PM |
| Cotroneo Pat | SVP, Finance and CFO | Jun 08, 2018 | Sale | $55.55 | 1,011 | 56,161 | 227,023 | Jun 08, 2018, 07:18 PM |
| Yu K Peony | Chief Medical Officer | Jun 01, 2018 | Option Exercise | $54.05 | 993 | 53,672 | 153,260 | Jun 05, 2018, 07:44 PM |
| Neff Thomas B | Chief Executive Officer | Jun 01, 2018 | Option Exercise | $54.05 | 2,287 | 123,612 | 2,869,566 | Jun 05, 2018, 07:42 PM |
| Neff Thomas B | Chief Executive Officer | Jun 04, 2018 | Option Exercise | $3.60 | 10,320 | 37,152 | 2,879,886 | Jun 05, 2018, 07:42 PM |
| Neff Thomas B | Chief Executive Officer | Jun 05, 2018 | Option Exercise | $3.60 | 10,320 | 37,152 | 2,871,306 | Jun 05, 2018, 07:42 PM |
| Neff Thomas B | Chief Executive Officer | Jun 04, 2018 | Sale | $54.80 | 918 | 50,305 | 110,718 | Jun 05, 2018, 07:42 PM |
| Neff Thomas B | Chief Executive Officer | Jun 04, 2018 | Sale | $54.70 | 18,900 | 1,033,898 | 2,871,156 | Jun 05, 2018, 07:42 PM |
| Neff Thomas B | Chief Executive Officer | Jun 05, 2018 | Sale | $54.94 | 918 | 50,435 | 109,482 | Jun 05, 2018, 07:42 PM |
| Neff Thomas B | Chief Executive Officer | Jun 05, 2018 | Sale | $55.02 | 18,900 | 1,039,959 | 2,855,106 | Jun 05, 2018, 07:42 PM |
| Cotroneo Pat | SVP, Finance and CFO | Jun 01, 2018 | Option Exercise | $54.05 | 993 | 53,672 | 230,311 | Jun 05, 2018, 07:40 PM |
| Cotroneo Pat | SVP, Finance and CFO | Jun 04, 2018 | Option Exercise | $19.39 | 6,013 | 116,592 | 236,324 | Jun 05, 2018, 07:40 PM |
| Cotroneo Pat | SVP, Finance and CFO | Jun 04, 2018 | Sale | $55.16 | 6,013 | 331,677 | 230,311 | Jun 05, 2018, 07:40 PM |
| Cotroneo Pat | SVP, Finance and CFO | May 21, 2018 | Option Exercise | $22.20 | 14,987 | 332,668 | 246,291 | May 23, 2018, 07:30 PM |
| Cotroneo Pat | SVP, Finance and CFO | May 21, 2018 | Sale | $55.04 | 14,987 | 824,884 | 231,304 | May 23, 2018, 07:30 PM |
| Rosenkranz Roberto Pedro | Director | May 17, 2018 | Option Exercise | $9.77 | 1,000 | 9,775 | 30,000 | May 18, 2018, 04:07 PM |
| Rosenkranz Roberto Pedro | Director | May 17, 2018 | Sale | $52.20 | 1,000 | 52,200 | 29,000 | May 18, 2018, 04:07 PM |
| Neff Thomas B | Chief Executive Officer | May 17, 2018 | Option Exercise | $3.60 | 10,320 | 37,152 | 2,890,753 | May 18, 2018, 04:06 PM |
| Neff Thomas B | Chief Executive Officer | May 16, 2018 | Option Exercise | $3.60 | 10,320 | 37,152 | 2,899,333 | May 18, 2018, 04:06 PM |
| Neff Thomas B | Chief Executive Officer | May 17, 2018 | Sale | $51.66 | 18,900 | 976,322 | 2,872,953 | May 18, 2018, 04:06 PM |
| Neff Thomas B | Chief Executive Officer | May 16, 2018 | Sale | $52.04 | 918 | 47,773 | 112,236 | May 18, 2018, 04:06 PM |
| Neff Thomas B | Chief Executive Officer | May 16, 2018 | Sale | $51.99 | 18,900 | 982,545 | 2,889,443 | May 18, 2018, 04:06 PM |
| Neff Thomas B | Chief Executive Officer | May 17, 2018 | Sale | $51.62 | 918 | 47,387 | 111,318 | May 18, 2018, 04:06 PM |
| Kurkijarvi Kalevi | Director | May 17, 2018 | Option Exercise | $2.90 | 4,000 | 11,600 | 24,000 | May 18, 2018, 04:04 PM |
| Kurkijarvi Kalevi | Director | May 17, 2018 | Sale | $51.83 | 4,000 | 207,320 | 20,000 | May 18, 2018, 04:04 PM |
| Routti Jorma | Director | May 09, 2018 | Option Exercise | $9.77 | 6,000 | 58,650 | 133,840 | May 11, 2018, 04:34 PM |
| Routti Jorma | Director | May 09, 2018 | Sale | $47.10 | 6,000 | 282,600 | 127,840 | May 11, 2018, 04:34 PM |
| Neff Thomas B | Chief Executive Officer | May 02, 2018 | Option Exercise | $3.60 | 10,320 | 37,152 | 2,916,493 | May 04, 2018, 05:10 PM |
| Neff Thomas B | Chief Executive Officer | May 03, 2018 | Option Exercise | $3.60 | 10,320 | 37,152 | 2,907,913 | May 04, 2018, 05:10 PM |
| Neff Thomas B | Chief Executive Officer | May 02, 2018 | Sale | $47.33 | 18,900 | 894,537 | 2,897,593 | May 04, 2018, 05:10 PM |
| Neff Thomas B | Chief Executive Officer | May 03, 2018 | Sale | $46.63 | 918 | 42,806 | 113,154 | May 04, 2018, 05:10 PM |
| Neff Thomas B | Chief Executive Officer | May 03, 2018 | Sale | $46.75 | 18,900 | 883,570 | 2,891,913 | May 04, 2018, 05:10 PM |
| Neff Thomas B | Chief Executive Officer | May 02, 2018 | Sale | $47.32 | 918 | 43,440 | 114,072 | May 04, 2018, 05:10 PM |
| Cotroneo Pat | VP, Finance and CFO | Apr 23, 2018 | Option Exercise | $2.90 | 33,550 | 97,295 | 229,884 | Apr 25, 2018, 06:05 PM |
| Rosenkranz Roberto Pedro | Director | Apr 19, 2018 | Option Exercise | $9.77 | 1,000 | 9,775 | 30,000 | Apr 20, 2018, 06:29 PM |
| Rosenkranz Roberto Pedro | Director | Apr 19, 2018 | Sale | $47.70 | 1,000 | 47,700 | 29,000 | Apr 20, 2018, 06:29 PM |
| Kurkijarvi Kalevi | Director | Apr 19, 2018 | Option Exercise | $2.90 | 4,000 | 11,600 | 24,000 | Apr 20, 2018, 06:26 PM |
| Kurkijarvi Kalevi | Director | Apr 19, 2018 | Sale | $47.69 | 4,000 | 190,760 | 20,000 | Apr 20, 2018, 06:26 PM |
| Neff Thomas B | Chief Executive Officer | Apr 18, 2018 | Option Exercise | $3.60 | 10,320 | 37,152 | 2,925,073 | Apr 19, 2018, 08:37 PM |
| Neff Thomas B | Chief Executive Officer | Apr 17, 2018 | Option Exercise | $3.60 | 10,320 | 37,152 | 2,933,653 | Apr 19, 2018, 08:37 PM |
| Neff Thomas B | Chief Executive Officer | Apr 18, 2018 | Sale | $48.60 | 918 | 44,615 | 114,990 | Apr 19, 2018, 08:37 PM |
| Neff Thomas B | Chief Executive Officer | Apr 18, 2018 | Sale | $48.70 | 18,900 | 920,484 | 2,906,973 | Apr 19, 2018, 08:37 PM |
| Neff Thomas B | Chief Executive Officer | Apr 17, 2018 | Sale | $48.54 | 918 | 44,560 | 115,908 | Apr 19, 2018, 08:37 PM |
| Neff Thomas B | Chief Executive Officer | Apr 17, 2018 | Sale | $48.41 | 18,900 | 914,971 | 2,928,453 | Apr 19, 2018, 08:37 PM |
| Yu K Peony | Chief Medical Officer | Apr 16, 2018 | Sale | $47.81 | 7,500 | 358,553 | 156,233 | Apr 18, 2018, 06:27 PM |
| Routti Jorma | Director | Apr 09, 2018 | Option Exercise | $5.95 | 6,000 | 35,700 | 133,840 | Apr 11, 2018, 07:21 PM |
| Routti Jorma | Director | Apr 09, 2018 | Sale | $46.59 | 6,000 | 279,554 | 132,440 | Apr 11, 2018, 07:21 PM |
| Neff Thomas B | Chief Executive Officer | Apr 04, 2018 | Option Exercise | $3.60 | 10,320 | 37,152 | 2,950,813 | Apr 06, 2018, 07:55 PM |
| Neff Thomas B | Chief Executive Officer | Apr 05, 2018 | Option Exercise | $3.60 | 10,320 | 37,152 | 2,942,233 | Apr 06, 2018, 07:55 PM |
| Neff Thomas B | Chief Executive Officer | Apr 04, 2018 | Sale | $45.65 | 918 | 41,909 | 117,962 | Apr 06, 2018, 07:55 PM |
| Neff Thomas B | Chief Executive Officer | Apr 04, 2018 | Sale | $45.57 | 18,900 | 861,362 | 2,940,713 | Apr 06, 2018, 07:55 PM |
| Neff Thomas B | Chief Executive Officer | Apr 05, 2018 | Sale | $45.40 | 918 | 41,677 | 117,126 | Apr 06, 2018, 07:55 PM |
| Neff Thomas B | Chief Executive Officer | Apr 05, 2018 | Sale | $45.61 | 18,900 | 861,945 | 2,931,733 | Apr 06, 2018, 07:55 PM |
| Neff Thomas B | Chief Executive Officer | Mar 20, 2018 | Option Exercise | $3.60 | 9,042 | 32,551 | 2,969,251 | Mar 22, 2018, 07:19 PM |
| Neff Thomas B | Chief Executive Officer | Mar 21, 2018 | Option Exercise | $3.60 | 9,042 | 32,551 | 2,959,393 | Mar 22, 2018, 07:19 PM |
| Neff Thomas B | Chief Executive Officer | Mar 21, 2018 | Sale | $51.19 | 19,818 | 1,014,464 | 2,941,393 | Mar 22, 2018, 07:19 PM |
| Neff Thomas B | Chief Executive Officer | Mar 20, 2018 | Sale | $50.71 | 918 | 46,552 | 119,580 | Mar 22, 2018, 07:19 PM |
| Neff Thomas B | Chief Executive Officer | Mar 20, 2018 | Sale | $50.72 | 18,900 | 958,604 | 2,954,319 | Mar 22, 2018, 07:19 PM |
| Yu K Peony | Chief Medical Officer | Mar 14, 2018 | Sale | $53.20 | 9,891 | 526,201 | 128,333 | Mar 16, 2018, 06:05 PM |
| Rosenkranz Roberto Pedro | Director | Mar 15, 2018 | Option Exercise | $9.77 | 1,000 | 9,775 | 30,000 | Mar 16, 2018, 06:04 PM |
| Rosenkranz Roberto Pedro | Director | Mar 15, 2018 | Sale | $52.34 | 1,000 | 52,339 | 29,300 | Mar 16, 2018, 06:04 PM |
| Kurkijarvi Kalevi | Director | Mar 15, 2018 | Option Exercise | $2.90 | 4,000 | 11,600 | 24,000 | Mar 16, 2018, 06:01 PM |
| Kurkijarvi Kalevi | Director | Mar 15, 2018 | Sale | $52.44 | 4,000 | 209,764 | 21,100 | Mar 16, 2018, 06:01 PM |
| Tamura Toshinari | Director | Mar 13, 2018 | Option Exercise | $18.17 | 24,000 | 436,080 | 72,000 | Mar 15, 2018, 08:14 PM |
| Tamura Toshinari | Director | Mar 13, 2018 | Sale | $53.37 | 24,000 | 1,280,898 | 57,844 | Mar 15, 2018, 08:14 PM |
| Cotroneo Pat | VP, Finance and CFO | Mar 15, 2018 | Option Exercise | $25.68 | 36,094 | 926,768 | 232,428 | Mar 15, 2018, 08:11 PM |
| Cotroneo Pat | VP, Finance and CFO | Mar 15, 2018 | Sale | $52.56 | 36,094 | 1,896,923 | 210,138 | Mar 15, 2018, 08:11 PM |
| Cotroneo Pat | VP, Finance and CFO | Mar 13, 2018 | Sale | $54.61 | 5,932 | 323,947 | 168,334 | Mar 15, 2018, 08:11 PM |
| RIGGS RORY B | Director | Mar 13, 2018 | Sale | $54.16 | 12,402 | 671,743 | 386,200 | Mar 14, 2018, 08:19 PM |
| RIGGS RORY B | Director | Mar 12, 2018 | Sale | $54.98 | 19,693 | 1,082,721 | 391,602 | Mar 14, 2018, 08:19 PM |
| KEARNS THOMAS F JR | Director | Mar 12, 2018 | Option Exercise | $3.60 | 18,000 | 64,800 | 153,064 | Mar 13, 2018, 08:20 PM |
| KEARNS THOMAS F JR | Director | Mar 12, 2018 | Sale | $55.00 | 18,000 | 990,000 | 135,064 | Mar 13, 2018, 08:20 PM |
| RIGGS RORY B | Director | Mar 09, 2018 | Sale | $55.75 | 22,905 | 1,276,954 | 411,295 | Mar 09, 2018, 07:48 PM |
| Yu K Peony | Chief Medical Officer | Mar 06, 2018 | Option Exercise | $53.55 | 5,065 | 271,231 | 138,224 | Mar 08, 2018, 08:43 PM |
| Neff Thomas B | Chief Executive Officer | Mar 06, 2018 | Option Exercise | $53.55 | 16,199 | 867,456 | 2,907,425 | Mar 08, 2018, 08:42 PM |
| Neff Thomas B | Chief Executive Officer | Mar 07, 2018 | Option Exercise | $2.35 | 10,265 | 24,123 | 2,917,690 | Mar 08, 2018, 08:42 PM |
| Neff Thomas B | Chief Executive Officer | Mar 08, 2018 | Option Exercise | $2.75 | 10,319 | 28,392 | 2,909,109 | Mar 08, 2018, 08:42 PM |
| Neff Thomas B | Chief Executive Officer | Mar 07, 2018 | Sale | $53.05 | 18,900 | 1,002,651 | 2,908,888 | Mar 08, 2018, 08:42 PM |
| Neff Thomas B | Chief Executive Officer | Mar 08, 2018 | Sale | $53.25 | 918 | 48,884 | 121,116 | Mar 08, 2018, 08:42 PM |
| Neff Thomas B | Chief Executive Officer | Mar 08, 2018 | Sale | $53.23 | 18,900 | 1,005,991 | 2,902,709 | Mar 08, 2018, 08:42 PM |
| Neff Thomas B | Chief Executive Officer | Mar 07, 2018 | Sale | $53.08 | 918 | 48,726 | 121,634 | Mar 08, 2018, 08:42 PM |
| Cotroneo Pat | VP, Finance and CFO | Mar 06, 2018 | Option Exercise | $53.55 | 5,832 | 312,304 | 176,160 | Mar 08, 2018, 08:40 PM |
| Cotroneo Pat | VP, Finance and CFO | Mar 08, 2018 | Sale | $53.12 | 1,894 | 100,617 | 175,254 | Mar 08, 2018, 08:40 PM |
| Yu K Peony | Chief Medical Officer | Mar 01, 2018 | Option Exercise | $54.95 | 1,297 | 71,270 | 143,289 | Mar 05, 2018, 06:49 PM |
| Neff Thomas B | Chief Executive Officer | Mar 01, 2018 | Option Exercise | $54.95 | 4,455 | 244,802 | 2,923,624 | Mar 05, 2018, 06:48 PM |
| Cotroneo Pat | VP, Finance and CFO | Mar 01, 2018 | Option Exercise | $54.95 | 1,860 | 102,207 | 181,992 | Mar 05, 2018, 06:46 PM |
| Neff Thomas B | Chief Executive Officer | Feb 22, 2018 | Option Exercise | $2.35 | 10,265 | 24,123 | 2,955,614 | Feb 23, 2018, 09:58 PM |
| Neff Thomas B | Chief Executive Officer | Feb 23, 2018 | Option Exercise | $2.35 | 10,265 | 24,123 | 2,946,979 | Feb 23, 2018, 09:58 PM |
| Neff Thomas B | Chief Executive Officer | Feb 22, 2018 | Sale | $57.00 | 18,900 | 1,077,350 | 2,946,865 | Feb 23, 2018, 09:58 PM |
| Neff Thomas B | Chief Executive Officer | Feb 23, 2018 | Sale | $56.39 | 918 | 51,767 | 122,752 | Feb 23, 2018, 09:58 PM |
| Neff Thomas B | Chief Executive Officer | Feb 23, 2018 | Sale | $56.32 | 18,900 | 1,064,445 | 2,935,579 | Feb 23, 2018, 09:58 PM |
| Neff Thomas B | Chief Executive Officer | Feb 22, 2018 | Sale | $56.90 | 918 | 52,233 | 123,552 | Feb 23, 2018, 09:58 PM |
| Neff Thomas B | Chief Executive Officer | Dec 19, 2016 | Option Exercise | $4.03 | 24,844 | 99,997 | 2,945,349 | Feb 23, 2018, 04:17 PM |
| Routti Jorma | Director | Feb 14, 2018 | Option Exercise | $3.50 | 6,000 | 21,000 | 133,840 | Feb 16, 2018, 05:55 PM |
| Routti Jorma | Director | Feb 15, 2018 | Option Exercise | $3.50 | 6,000 | 21,000 | 133,840 | Feb 16, 2018, 05:55 PM |
| Routti Jorma | Director | Feb 15, 2018 | Sale | $55.72 | 6,000 | 334,308 | 129,240 | Feb 16, 2018, 05:55 PM |
| Routti Jorma | Director | Feb 14, 2018 | Sale | $54.88 | 6,000 | 329,258 | 132,647 | Feb 16, 2018, 05:55 PM |
| Rosenkranz Roberto Pedro | Director | Feb 15, 2018 | Option Exercise | $9.77 | 1,000 | 9,775 | 30,000 | Feb 16, 2018, 05:53 PM |
| Rosenkranz Roberto Pedro | Director | Feb 15, 2018 | Sale | $55.90 | 1,000 | 55,898 | 29,300 | Feb 16, 2018, 05:53 PM |
| Cotroneo Pat | VP, Finance and CFO | Feb 15, 2018 | Option Exercise | $23.63 | 45,540 | 1,076,240 | 229,392 | Feb 16, 2018, 05:51 PM |
| Cotroneo Pat | VP, Finance and CFO | Feb 16, 2018 | Option Exercise | $18.00 | 3,960 | 71,280 | 187,812 | Feb 16, 2018, 05:51 PM |
| Cotroneo Pat | VP, Finance and CFO | Feb 16, 2018 | Sale | $56.28 | 3,960 | 222,866 | 184,412 | Feb 16, 2018, 05:51 PM |
| Cotroneo Pat | VP, Finance and CFO | Feb 15, 2018 | Sale | $55.93 | 45,540 | 2,547,213 | 227,492 | Feb 16, 2018, 05:51 PM |
| Kurkijarvi Kalevi | Director | Feb 15, 2018 | Option Exercise | $2.90 | 6,000 | 17,400 | 26,000 | Feb 16, 2018, 05:40 PM |
| Kurkijarvi Kalevi | Director | Feb 15, 2018 | Sale | $55.69 | 6,000 | 334,119 | 21,100 | Feb 16, 2018, 05:40 PM |
| Yu K Peony | Chief Medical Officer | Feb 08, 2018 | Sale | $53.97 | 7,500 | 404,778 | 144,986 | Feb 09, 2018, 07:25 PM |
| Yu K Peony | Chief Medical Officer | Jan 29, 2018 | Sale | $62.00 | 10,000 | 620,000 | 152,086 | Jan 31, 2018, 08:35 PM |
| Neff Thomas B | Chief Executive Officer | Jan 29, 2018 | Sale | $61.64 | 418 | 25,766 | 124,588 | Jan 31, 2018, 08:32 PM |
| Neff Thomas B | Chief Executive Officer | Jan 29, 2018 | Sale | $61.63 | 18,900 | 1,164,718 | 2,958,105 | Jan 31, 2018, 08:32 PM |
| Neff Thomas B | Chief Executive Officer | Jan 30, 2018 | Sale | $61.28 | 418 | 25,615 | 124,170 | Jan 31, 2018, 08:32 PM |
| Neff Thomas B | Chief Executive Officer | Jan 30, 2018 | Sale | $61.16 | 18,900 | 1,155,996 | 2,929,405 | Jan 31, 2018, 08:32 PM |
| Rosenkranz Roberto Pedro | Director | Jan 26, 2018 | Sale | $60.00 | 6,000 | 360,000 | 29,000 | Jan 30, 2018, 08:23 PM |
| Rosenkranz Roberto Pedro | Director | Jan 22, 2018 | Sale | $50.00 | 71 | 3,550 | 36,929 | Jan 24, 2018, 08:38 PM |
| Rosenkranz Roberto Pedro | Director | Jan 23, 2018 | Sale | $50.00 | 1,929 | 96,450 | 35,000 | Jan 24, 2018, 08:38 PM |
| Cotroneo Pat | VP, Finance and CFO | Jan 22, 2018 | Option Exercise | $18.00 | 25,000 | 450,000 | 208,852 | Jan 24, 2018, 08:37 PM |
| Cotroneo Pat | VP, Finance and CFO | Jan 22, 2018 | Sale | $48.72 | 25,000 | 1,217,954 | 197,050 | Jan 24, 2018, 08:37 PM |
| Rosenkranz Roberto Pedro | Director | Jan 18, 2018 | Option Exercise | $9.77 | 1,000 | 9,775 | 43,000 | Jan 19, 2018, 08:25 PM |
| Rosenkranz Roberto Pedro | Director | Jan 18, 2018 | Sale | $47.45 | 6,000 | 284,695 | 38,000 | Jan 19, 2018, 08:25 PM |
| Neff Thomas B | Chief Executive Officer | Jan 19, 2018 | Sale | $47.11 | 418 | 19,692 | 125,006 | Jan 19, 2018, 08:23 PM |
| Neff Thomas B | Chief Executive Officer | Jan 19, 2018 | Sale | $47.28 | 18,900 | 893,552 | 2,962,005 | Jan 19, 2018, 08:23 PM |
| Neff Thomas B | Chief Executive Officer | Jan 18, 2018 | Sale | $47.51 | 418 | 19,859 | 125,424 | Jan 19, 2018, 08:23 PM |
| Neff Thomas B | Chief Executive Officer | Jan 18, 2018 | Sale | $47.64 | 18,900 | 900,411 | 2,981,447 | Jan 19, 2018, 08:23 PM |
| Kurkijarvi Kalevi | Director | Jan 18, 2018 | Option Exercise | $2.90 | 6,000 | 17,400 | 28,000 | Jan 19, 2018, 08:22 PM |
| Kurkijarvi Kalevi | Director | Jan 18, 2018 | Sale | $47.38 | 6,000 | 284,268 | 22,600 | Jan 19, 2018, 08:22 PM |
| Neff Thomas B | Chief Executive Officer | Jan 05, 2018 | Sale | $45.84 | 418 | 19,161 | 125,842 | Jan 08, 2018, 08:10 PM |
| Neff Thomas B | Chief Executive Officer | Jan 05, 2018 | Sale | $46.37 | 18,900 | 876,412 | 3,004,205 | Jan 08, 2018, 08:10 PM |
| Neff Thomas B | Chief Executive Officer | Jan 04, 2018 | Sale | $48.89 | 418 | 20,436 | 126,260 | Jan 08, 2018, 08:10 PM |
| Neff Thomas B | Chief Executive Officer | Jan 04, 2018 | Sale | $48.86 | 18,900 | 923,544 | 3,029,887 | Jan 08, 2018, 08:10 PM |
| Neff Thomas B | Chief Executive Officer | Dec 29, 2017 | Sale | $48.49 | 18,900 | 916,381 | 3,043,718 | Jan 02, 2018, 08:24 PM |
| Neff Thomas B | Chief Executive Officer | Dec 28, 2017 | Sale | $48.30 | 418 | 20,189 | 127,096 | Jan 02, 2018, 08:24 PM |
| Neff Thomas B | Chief Executive Officer | Dec 28, 2017 | Sale | $48.29 | 18,900 | 912,646 | 3,053,155 | Jan 02, 2018, 08:24 PM |
| Neff Thomas B | Chief Executive Officer | Dec 29, 2017 | Sale | $48.36 | 418 | 20,214 | 126,678 | Jan 02, 2018, 08:24 PM |
| Neff Thomas B | Chief Executive Officer | Dec 21, 2017 | Option Exercise | $3.26 | 80,000 | 260,413 | 3,091,105 | Dec 22, 2017, 04:32 PM |
| Neff Thomas B | Chief Executive Officer | Dec 20, 2017 | Sale | $43.64 | 418 | 18,242 | 127,932 | Dec 22, 2017, 04:32 PM |
| Neff Thomas B | Chief Executive Officer | Dec 20, 2017 | Sale | $44.12 | 18,900 | 833,809 | 3,022,934 | Dec 22, 2017, 04:32 PM |
| Neff Thomas B | Chief Executive Officer | Dec 21, 2017 | Sale | $45.22 | 418 | 18,902 | 127,514 | Dec 22, 2017, 04:32 PM |
| Neff Thomas B | Chief Executive Officer | Dec 21, 2017 | Sale | $45.22 | 18,900 | 854,702 | 3,081,728 | Dec 22, 2017, 04:32 PM |
| Kurkijarvi Kalevi | Director | Dec 18, 2017 | Sale | $42.80 | 2,000 | 85,600 | 22,000 | Dec 19, 2017, 07:27 PM |
| Yu K Peony | Chief Medical Officer | Dec 14, 2017 | Sale | $43.70 | 2,851 | 124,589 | 162,086 | Dec 15, 2017, 07:17 PM |
| Neff Thomas B | Chief Executive Officer | Dec 14, 2017 | Sale | $42.71 | 18,900 | 807,265 | 3,060,887 | Dec 15, 2017, 07:15 PM |
| Neff Thomas B | Chief Executive Officer | Dec 15, 2017 | Sale | $41.49 | 418 | 17,343 | 128,350 | Dec 15, 2017, 07:15 PM |
| Neff Thomas B | Chief Executive Officer | Dec 15, 2017 | Sale | $41.69 | 18,900 | 787,950 | 3,038,353 | Dec 15, 2017, 07:15 PM |
| Neff Thomas B | Chief Executive Officer | Dec 14, 2017 | Sale | $42.23 | 418 | 17,651 | 128,826 | Dec 15, 2017, 07:15 PM |
| Kurkijarvi Kalevi | Director | Dec 12, 2017 | Option Exercise | $2.90 | 12,000 | 34,800 | 36,000 | Dec 13, 2017, 07:11 PM |
| Kurkijarvi Kalevi | Director | Dec 12, 2017 | Sale | $44.45 | 12,000 | 533,400 | 24,000 | Dec 13, 2017, 07:11 PM |
| Cotroneo Pat | VP, Finance and CFO | Dec 11, 2017 | Sale | $46.00 | 2,851 | 131,146 | 183,852 | Dec 13, 2017, 07:10 PM |
| Yu K Peony | Chief Medical Officer | Dec 06, 2017 | Option Exercise | $44.85 | 1,151 | 51,622 | 164,937 | Dec 08, 2017, 06:23 PM |
| Neff Thomas B | Chief Executive Officer | Dec 06, 2017 | Option Exercise | $44.85 | 3,261 | 146,256 | 3,067,805 | Dec 08, 2017, 06:19 PM |
| Cotroneo Pat | VP, Finance and CFO | Dec 06, 2017 | Option Exercise | $44.85 | 1,151 | 51,622 | 186,703 | Dec 08, 2017, 06:18 PM |
| Lema Gerald | Director | Dec 04, 2017 | Buy | $46.70 | 3,500 | 163,450 | 3,500 | Dec 05, 2017, 07:45 PM |
| Yu K Peony | Chief Medical Officer | Dec 01, 2017 | Option Exercise | $47.15 | 1,958 | 92,320 | 166,088 | Dec 05, 2017, 07:43 PM |
| Neff Thomas B | Chief Executive Officer | Dec 01, 2017 | Option Exercise | $47.15 | 4,689 | 221,086 | 3,071,066 | Dec 05, 2017, 07:42 PM |
| Cotroneo Pat | VP, Finance and CFO | Dec 01, 2017 | Option Exercise | $47.15 | 1,958 | 92,320 | 187,854 | Dec 05, 2017, 07:41 PM |
| Routti Jorma | Director | Dec 01, 2017 | Option Exercise | $2.90 | 6,000 | 17,400 | 133,840 | Dec 04, 2017, 08:23 PM |
| Routti Jorma | Director | Nov 30, 2017 | Option Exercise | $2.90 | 6,000 | 17,400 | 133,840 | Dec 04, 2017, 08:23 PM |
| Routti Jorma | Director | Nov 30, 2017 | Sale | $47.18 | 6,000 | 283,080 | 127,840 | Dec 04, 2017, 08:23 PM |
| Routti Jorma | Director | Dec 01, 2017 | Sale | $47.32 | 6,000 | 283,920 | 127,840 | Dec 04, 2017, 08:23 PM |
| Kurkijarvi Kalevi | Director | Nov 17, 2017 | Sale | $46.65 | 2,000 | 93,300 | 24,000 | Nov 20, 2017, 07:43 PM |
| KEARNS THOMAS F JR | Director | Nov 15, 2017 | Option Exercise | $2.35 | 18,000 | 42,300 | 156,564 | Nov 17, 2017, 07:07 PM |
| KEARNS THOMAS F JR | Director | Nov 15, 2017 | Sale | $45.22 | 18,000 | 813,960 | 138,564 | Nov 17, 2017, 07:07 PM |
| Neff Thomas B | Chief Executive Officer | Nov 17, 2017 | Sale | $46.66 | 18,900 | 881,842 | 3,078,655 | Nov 17, 2017, 07:05 PM |
| Neff Thomas B | Chief Executive Officer | Nov 16, 2017 | Sale | $46.75 | 418 | 19,542 | 129,604 | Nov 17, 2017, 07:05 PM |
| Neff Thomas B | Chief Executive Officer | Nov 16, 2017 | Sale | $46.60 | 18,900 | 880,713 | 3,109,555 | Nov 17, 2017, 07:05 PM |
| Neff Thomas B | Chief Executive Officer | Nov 17, 2017 | Sale | $46.75 | 418 | 19,542 | 129,186 | Nov 17, 2017, 07:05 PM |
| Cotroneo Pat | VP, Finance and CFO | Nov 09, 2017 | Option Exercise | $2.90 | 32,407 | 93,980 | 189,812 | Nov 13, 2017, 08:14 PM |
| Yu K Peony | Chief Medical Officer | Nov 06, 2017 | Sale | $55.37 | 7,500 | 415,243 | 170,104 | Nov 08, 2017, 08:19 PM |
| Neff Thomas B | Chief Executive Officer | Oct 31, 2017 | Sale | $55.84 | 18,900 | 1,055,305 | 3,120,255 | Nov 01, 2017, 05:44 PM |
| Neff Thomas B | Chief Executive Officer | Oct 30, 2017 | Sale | $55.84 | 418 | 23,342 | 130,450 | Nov 01, 2017, 05:44 PM |
| Neff Thomas B | Chief Executive Officer | Oct 30, 2017 | Sale | $56.42 | 18,900 | 1,066,415 | 3,144,573 | Nov 01, 2017, 05:44 PM |
| Neff Thomas B | Chief Executive Officer | Oct 31, 2017 | Sale | $55.95 | 418 | 23,387 | 130,022 | Nov 01, 2017, 05:44 PM |
| Kurkijarvi Kalevi | Director | Oct 17, 2017 | Sale | $52.24 | 2,000 | 104,480 | 26,000 | Oct 18, 2017, 06:18 PM |
| Neff Thomas B | Chief Executive Officer | Oct 16, 2017 | Sale | $54.83 | 18,900 | 1,036,289 | 3,176,861 | Oct 18, 2017, 06:17 PM |
| Neff Thomas B | Chief Executive Officer | Oct 17, 2017 | Sale | $55.21 | 418 | 23,079 | 131,176 | Oct 18, 2017, 06:17 PM |
| Neff Thomas B | Chief Executive Officer | Oct 17, 2017 | Sale | $55.23 | 18,900 | 1,043,784 | 3,166,055 | Oct 18, 2017, 06:17 PM |
| Neff Thomas B | Chief Executive Officer | Oct 16, 2017 | Sale | $54.35 | 418 | 22,719 | 131,277 | Oct 18, 2017, 06:17 PM |
| Yu K Peony | Chief Medical Officer | Oct 04, 2017 | Option Exercise | $14.57 | 15,000 | 218,625 | 190,546 | Oct 06, 2017, 06:29 PM |
| Yu K Peony | Chief Medical Officer | Oct 04, 2017 | Sale | $60.00 | 15,000 | 900,000 | 175,546 | Oct 06, 2017, 06:29 PM |
| Yu K Peony | Chief Medical Officer | Oct 02, 2017 | Option Exercise | $14.57 | 30,000 | 437,250 | 215,546 | Oct 04, 2017, 04:38 PM |
| Yu K Peony | Chief Medical Officer | Oct 02, 2017 | Sale | $54.63 | 40,000 | 2,185,000 | 204,546 | Oct 04, 2017, 04:38 PM |
| Neff Thomas B | Chief Executive Officer | Oct 03, 2017 | Sale | $55.71 | 18,900 | 1,052,919 | 3,189,155 | Oct 04, 2017, 04:36 PM |
| Neff Thomas B | Chief Executive Officer | Oct 02, 2017 | Sale | $54.94 | 418 | 22,965 | 132,212 | Oct 04, 2017, 04:36 PM |
| Neff Thomas B | Chief Executive Officer | Oct 02, 2017 | Sale | $54.45 | 18,900 | 1,029,072 | 3,217,455 | Oct 04, 2017, 04:36 PM |
| Neff Thomas B | Chief Executive Officer | Oct 03, 2017 | Sale | $55.88 | 418 | 23,357 | 131,794 | Oct 04, 2017, 04:36 PM |
| Neff Thomas B | Chief Executive Officer | Sep 20, 2017 | Sale | $53.48 | 418 | 22,355 | 132,520 | Sep 21, 2017, 06:08 PM |
| Neff Thomas B | Chief Executive Officer | Sep 20, 2017 | Sale | $53.69 | 18,900 | 1,014,741 | 3,226,955 | Sep 21, 2017, 06:08 PM |
| Neff Thomas B | Chief Executive Officer | Sep 19, 2017 | Sale | $52.85 | 418 | 22,091 | 132,948 | Sep 21, 2017, 06:08 PM |
| Neff Thomas B | Chief Executive Officer | Sep 19, 2017 | Sale | $53.24 | 18,900 | 1,006,299 | 3,246,754 | Sep 21, 2017, 06:08 PM |
| Kurkijarvi Kalevi | Director | Sep 18, 2017 | Sale | $52.55 | 2,000 | 105,100 | 28,000 | Sep 20, 2017, 07:56 PM |
| Kurkijarvi Kalevi | Director | Aug 17, 2017 | Sale | $40.74 | 2,000 | 81,480 | 30,000 | Sep 20, 2017, 07:56 PM |
| Yu K Peony | Chief Medical Officer | Sep 14, 2017 | Sale | $51.00 | 2,851 | 145,401 | 185,546 | Sep 15, 2017, 06:39 PM |
| RIGGS RORY B | Director | Sep 13, 2017 | Sale | $51.92 | 25,000 | 1,298,000 | 435,200 | Sep 15, 2017, 06:38 PM |
| Neff Thomas B | Chief Executive Officer | Sep 14, 2017 | Sale | $51.95 | 418 | 21,715 | 133,466 | Sep 15, 2017, 06:37 PM |
| Neff Thomas B | Chief Executive Officer | Sep 14, 2017 | Sale | $52.04 | 18,900 | 983,553 | 3,282,155 | Sep 15, 2017, 06:37 PM |
| Neff Thomas B | Chief Executive Officer | Sep 13, 2017 | Sale | $51.64 | 418 | 21,584 | 133,884 | Sep 15, 2017, 06:37 PM |
| Neff Thomas B | Chief Executive Officer | Sep 13, 2017 | Sale | $51.29 | 18,900 | 969,422 | 3,297,655 | Sep 15, 2017, 06:37 PM |
| Cotroneo Pat | VP, Finance and CFO | Sep 11, 2017 | Sale | $49.45 | 2,851 | 140,982 | 157,405 | Sep 13, 2017, 06:23 PM |
| Yu K Peony | Chief Medical Officer | Sep 06, 2017 | Option Exercise | $48.10 | 1,151 | 55,363 | 188,397 | Sep 06, 2017, 08:37 PM |
| Yu K Peony | Chief Medical Officer | Sep 01, 2017 | Option Exercise | $49.00 | 1,959 | 95,991 | 189,548 | Sep 06, 2017, 08:37 PM |
| Neff Thomas B | Chief Executive Officer | Sep 06, 2017 | Option Exercise | $48.10 | 3,261 | 156,854 | 3,302,555 | Sep 06, 2017, 08:36 PM |
| Neff Thomas B | Chief Executive Officer | Sep 01, 2017 | Option Exercise | $49.00 | 4,688 | 229,712 | 3,305,816 | Sep 06, 2017, 08:36 PM |
| Cotroneo Pat | VP, Finance and CFO | Sep 06, 2017 | Option Exercise | $48.10 | 1,151 | 55,363 | 160,256 | Sep 06, 2017, 08:01 PM |
| Cotroneo Pat | VP, Finance and CFO | Sep 01, 2017 | Option Exercise | $49.00 | 1,959 | 95,991 | 161,407 | Sep 06, 2017, 08:01 PM |
| Routti Jorma | Director | Sep 01, 2017 | Option Exercise | $3.60 | 6,000 | 21,600 | 133,840 | Sep 05, 2017, 09:27 PM |
| Routti Jorma | Director | Aug 31, 2017 | Option Exercise | $3.60 | 6,000 | 21,600 | 133,840 | Sep 05, 2017, 09:27 PM |
| Routti Jorma | Director | Sep 01, 2017 | Sale | $47.93 | 6,000 | 287,580 | 127,840 | Sep 05, 2017, 09:27 PM |
| Routti Jorma | Director | Aug 31, 2017 | Sale | $46.78 | 6,000 | 280,680 | 127,840 | Sep 05, 2017, 09:27 PM |
| Neff Thomas B | Chief Executive Officer | Aug 29, 2017 | Option Exercise | $2.35 | 17,524 | 41,181 | 3,329,404 | Aug 30, 2017, 07:51 PM |
| Neff Thomas B | Chief Executive Officer | Aug 28, 2017 | Option Exercise | $2.35 | 18,900 | 44,415 | 3,330,780 | Aug 30, 2017, 07:51 PM |
| Neff Thomas B | Chief Executive Officer | Aug 29, 2017 | Sale | $44.64 | 418 | 18,660 | 134,202 | Aug 30, 2017, 07:51 PM |
| Neff Thomas B | Chief Executive Officer | Aug 29, 2017 | Sale | $44.41 | 18,900 | 839,313 | 3,326,304 | Aug 30, 2017, 07:51 PM |
| Neff Thomas B | Chief Executive Officer | Aug 28, 2017 | Sale | $43.10 | 418 | 18,016 | 134,620 | Aug 30, 2017, 07:51 PM |
| Neff Thomas B | Chief Executive Officer | Aug 28, 2017 | Sale | $43.04 | 18,900 | 813,456 | 3,311,880 | Aug 30, 2017, 07:51 PM |
| Yu K Peony | Chief Medical Officer | Aug 21, 2017 | Sale | $41.03 | 7,500 | 307,725 | 191,507 | Aug 23, 2017, 06:47 PM |
| Yu K Peony | Chief Medical Officer | Aug 08, 2017 | Option Exercise | $14.57 | 20,000 | 291,500 | 236,507 | Aug 10, 2017, 07:16 PM |
| Yu K Peony | Chief Medical Officer | Aug 08, 2017 | Sale | $50.58 | 37,500 | 1,896,861 | 204,107 | Aug 10, 2017, 07:16 PM |
| Cotroneo Pat | VP, Finance and CFO | Aug 08, 2017 | Option Exercise | $13.41 | 95,000 | 1,273,875 | 258,366 | Aug 10, 2017, 07:14 PM |
| Cotroneo Pat | VP, Finance and CFO | Aug 08, 2017 | Sale | $50.61 | 95,000 | 4,808,038 | 247,377 | Aug 10, 2017, 07:14 PM |
| Yu K Peony | Chief Medical Officer | Aug 01, 2017 | Option Exercise | $14.57 | 10,000 | 145,750 | 226,507 | Aug 03, 2017, 08:18 PM |
| Yu K Peony | Chief Medical Officer | Aug 01, 2017 | Sale | $33.48 | 10,000 | 334,800 | 216,507 | Aug 03, 2017, 08:18 PM |
| Cotroneo Pat | VP, Finance and CFO | Aug 02, 2017 | Option Exercise | $8.22 | 20,746 | 170,445 | 184,112 | Aug 03, 2017, 08:16 PM |
| Cotroneo Pat | VP, Finance and CFO | Aug 01, 2017 | Option Exercise | $3.36 | 7,600 | 25,543 | 170,966 | Aug 03, 2017, 08:16 PM |
| Cotroneo Pat | VP, Finance and CFO | Aug 02, 2017 | Sale | $34.13 | 20,746 | 708,061 | 163,366 | Aug 03, 2017, 08:16 PM |
| Cotroneo Pat | VP, Finance and CFO | Aug 01, 2017 | Sale | $33.54 | 7,600 | 254,904 | 163,366 | Aug 03, 2017, 08:16 PM |
| Neff Thomas B | Chief Executive Officer | Jul 24, 2017 | Option Exercise | $2.35 | 18,900 | 44,415 | 3,330,780 | Jul 26, 2017, 04:41 PM |
| Neff Thomas B | Chief Executive Officer | Jul 25, 2017 | Option Exercise | $2.35 | 18,900 | 44,415 | 3,330,780 | Jul 26, 2017, 04:41 PM |
| Neff Thomas B | Chief Executive Officer | Jul 24, 2017 | Sale | $35.09 | 418 | 14,668 | 135,456 | Jul 26, 2017, 04:41 PM |
| Neff Thomas B | Chief Executive Officer | Jul 24, 2017 | Sale | $35.06 | 18,900 | 662,634 | 3,311,880 | Jul 26, 2017, 04:41 PM |
| Neff Thomas B | Chief Executive Officer | Jul 25, 2017 | Sale | $35.11 | 418 | 14,676 | 135,038 | Jul 26, 2017, 04:41 PM |
| Neff Thomas B | Chief Executive Officer | Jul 25, 2017 | Sale | $35.12 | 18,900 | 663,768 | 3,311,880 | Jul 26, 2017, 04:41 PM |
| Kurkijarvi Kalevi | Director | Jul 17, 2017 | Sale | $33.45 | 2,000 | 66,900 | 32,000 | Jul 18, 2017, 04:26 PM |
| Yu K Peony | Chief Medical Officer | Jul 10, 2017 | Sale | $32.98 | 5,000 | 164,900 | 216,507 | Jul 11, 2017, 07:38 PM |
| Neff Thomas B | Chief Executive Officer | Jul 07, 2017 | Option Exercise | $2.35 | 18,900 | 44,415 | 3,330,780 | Jul 07, 2017, 06:50 PM |
| Neff Thomas B | Chief Executive Officer | Jul 06, 2017 | Option Exercise | $2.35 | 18,900 | 44,415 | 3,330,780 | Jul 07, 2017, 06:50 PM |
| Neff Thomas B | Chief Executive Officer | Jul 07, 2017 | Sale | $33.22 | 18,900 | 627,858 | 3,311,880 | Jul 07, 2017, 06:50 PM |
| Neff Thomas B | Chief Executive Officer | Jul 06, 2017 | Sale | $33.49 | 418 | 14,000 | 136,492 | Jul 07, 2017, 06:50 PM |
| Neff Thomas B | Chief Executive Officer | Jul 06, 2017 | Sale | $33.53 | 18,900 | 633,795 | 3,321,480 | Jul 07, 2017, 06:50 PM |
| Neff Thomas B | Chief Executive Officer | Jul 07, 2017 | Sale | $33.24 | 418 | 13,894 | 135,874 | Jul 07, 2017, 06:50 PM |
| Cotroneo Pat | VP, Finance and CFO | Jul 06, 2017 | Option Exercise | $2.90 | 4,000 | 11,600 | 167,366 | Jul 07, 2017, 04:33 PM |
| Cotroneo Pat | VP, Finance and CFO | Jul 06, 2017 | Sale | $34.00 | 4,000 | 136,000 | 163,366 | Jul 07, 2017, 04:33 PM |
| Cotroneo Pat | VP, Finance and CFO | Jun 22, 2017 | Option Exercise | $2.90 | 3,000 | 8,700 | 166,366 | Jun 23, 2017, 04:39 PM |
| Cotroneo Pat | VP, Finance and CFO | Jun 22, 2017 | Sale | $32.00 | 3,000 | 96,000 | 163,366 | Jun 23, 2017, 04:39 PM |
| Neff Thomas B | Chief Executive Officer | Jun 22, 2017 | Option Exercise | $2.35 | 18,900 | 44,415 | 3,330,780 | Jun 23, 2017, 04:38 PM |
| Neff Thomas B | Chief Executive Officer | Jun 21, 2017 | Option Exercise | $2.35 | 18,900 | 44,415 | 3,330,780 | Jun 23, 2017, 04:38 PM |
| Neff Thomas B | Chief Executive Officer | Jun 22, 2017 | Sale | $32.02 | 418 | 13,384 | 136,710 | Jun 23, 2017, 04:38 PM |
| Neff Thomas B | Chief Executive Officer | Jun 22, 2017 | Sale | $31.88 | 18,900 | 602,476 | 3,314,080 | Jun 23, 2017, 04:38 PM |
| Neff Thomas B | Chief Executive Officer | Jun 21, 2017 | Sale | $31.22 | 418 | 13,050 | 137,128 | Jun 23, 2017, 04:38 PM |
| Neff Thomas B | Chief Executive Officer | Jun 21, 2017 | Sale | $31.15 | 18,900 | 588,735 | 3,311,880 | Jun 23, 2017, 04:38 PM |
| Cotroneo Pat | VP, Finance and CFO | Jun 19, 2017 | Option Exercise | $2.35 | 5,500 | 12,925 | 168,866 | Jun 21, 2017, 06:00 PM |
| Cotroneo Pat | VP, Finance and CFO | Jun 19, 2017 | Sale | $30.00 | 5,500 | 165,000 | 163,366 | Jun 21, 2017, 06:00 PM |
| Kurkijarvi Kalevi | Director | Jun 15, 2017 | Sale | $28.50 | 2,000 | 57,000 | 34,000 | Jun 19, 2017, 05:50 PM |
| Neff Thomas B | Chief Executive Officer | Jun 16, 2017 | Option Exercise | $2.35 | 18,900 | 44,415 | 3,330,780 | Jun 19, 2017, 05:49 PM |
| Neff Thomas B | Chief Executive Officer | Jun 15, 2017 | Option Exercise | $2.35 | 11,689 | 27,469 | 3,330,780 | Jun 19, 2017, 05:49 PM |
| Neff Thomas B | Chief Executive Officer | Jun 15, 2017 | Sale | $29.28 | 418 | 12,239 | 137,964 | Jun 19, 2017, 05:49 PM |
| Neff Thomas B | Chief Executive Officer | Jun 15, 2017 | Sale | $29.25 | 18,900 | 552,825 | 3,311,880 | Jun 19, 2017, 05:49 PM |
| Neff Thomas B | Chief Executive Officer | Jun 16, 2017 | Sale | $29.58 | 418 | 12,364 | 137,546 | Jun 19, 2017, 05:49 PM |
| Neff Thomas B | Chief Executive Officer | Jun 16, 2017 | Sale | $29.54 | 18,900 | 558,306 | 3,311,880 | Jun 19, 2017, 05:49 PM |
| Yu K Peony | Chief Medical Officer | Jun 14, 2017 | Sale | $28.95 | 3,721 | 107,723 | 221,507 | Jun 16, 2017, 04:49 PM |
| Cotroneo Pat | VP, Finance and CFO | Jun 12, 2017 | Sale | $28.75 | 2,891 | 83,116 | 163,366 | Jun 14, 2017, 07:00 PM |
| Tamura Toshinari | Director | Jun 12, 2017 | Option Exercise | $9.01 | 15,000 | 135,150 | 63,000 | Jun 13, 2017, 07:32 PM |
| Tamura Toshinari | Director | Jun 09, 2017 | Option Exercise | $3.99 | 15,000 | 59,850 | 63,000 | Jun 13, 2017, 07:32 PM |
| Tamura Toshinari | Director | Jun 12, 2017 | Sale | $28.57 | 15,000 | 428,550 | 48,000 | Jun 13, 2017, 07:32 PM |
| Tamura Toshinari | Director | Jun 09, 2017 | Sale | $29.20 | 15,000 | 438,000 | 48,000 | Jun 13, 2017, 07:32 PM |
| KEARNS THOMAS F JR | Director | Jun 06, 2017 | Option Exercise | $9.77 | 18,000 | 175,950 | 156,564 | Jun 08, 2017, 07:51 PM |
| KEARNS THOMAS F JR | Director | Jun 06, 2017 | Sale | $28.71 | 18,000 | 516,780 | 138,564 | Jun 08, 2017, 07:51 PM |
| Cotroneo Pat | VP, Finance and CFO | Jun 06, 2017 | Option Exercise | $29.05 | 1,151 | 33,437 | 166,257 | Jun 08, 2017, 07:49 PM |
| Yu K Peony | Chief Medical Officer | Jun 06, 2017 | Option Exercise | $29.05 | 829 | 24,082 | 225,228 | Jun 08, 2017, 07:36 PM |
| Neff Thomas B | Chief Executive Officer | Jun 06, 2017 | Option Exercise | $29.05 | 3,261 | 94,732 | 3,319,091 | Jun 08, 2017, 07:35 PM |
| Yu K Peony | Chief Medical Officer | Jun 01, 2017 | Option Exercise | $27.60 | 1,410 | 38,916 | 226,057 | Jun 02, 2017, 06:39 PM |
| Neff Thomas B | Chief Executive Officer | Jun 01, 2017 | Option Exercise | $27.60 | 4,689 | 129,416 | 3,322,352 | Jun 01, 2017, 07:23 PM |
| Neff Thomas B | Chief Executive Officer | May 31, 2017 | Option Exercise | $2.35 | 18,900 | 44,415 | 3,345,941 | Jun 01, 2017, 07:23 PM |
| Neff Thomas B | Chief Executive Officer | May 30, 2017 | Option Exercise | $2.35 | 18,900 | 44,415 | 3,345,941 | Jun 01, 2017, 07:23 PM |
| Neff Thomas B | Chief Executive Officer | May 30, 2017 | Sale | $26.30 | 418 | 10,993 | 138,800 | Jun 01, 2017, 07:23 PM |
| Neff Thomas B | Chief Executive Officer | May 30, 2017 | Sale | $26.45 | 18,900 | 499,824 | 3,334,541 | Jun 01, 2017, 07:23 PM |
| Neff Thomas B | Chief Executive Officer | May 31, 2017 | Sale | $26.03 | 418 | 10,881 | 138,382 | Jun 01, 2017, 07:23 PM |
| Neff Thomas B | Chief Executive Officer | May 31, 2017 | Sale | $25.97 | 18,900 | 490,833 | 3,327,041 | Jun 01, 2017, 07:23 PM |
| Cotroneo Pat | VP, Finance and CFO | Jun 01, 2017 | Option Exercise | $27.60 | 1,918 | 52,937 | 167,408 | Jun 01, 2017, 07:22 PM |
| Cotroneo Pat | VP, Finance and CFO | May 30, 2017 | Option Exercise | $2.90 | 10,000 | 29,000 | 169,326 | Jun 01, 2017, 07:22 PM |
| Kurkijarvi Kalevi | Director | May 16, 2017 | Sale | $27.40 | 2,000 | 54,800 | 36,000 | May 17, 2017, 09:06 PM |
| Neff Thomas B | Chief Executive Officer | May 16, 2017 | Option Exercise | $2.35 | 18,900 | 44,415 | 3,345,941 | May 17, 2017, 08:52 PM |
| Neff Thomas B | Chief Executive Officer | May 15, 2017 | Option Exercise | $2.35 | 18,900 | 44,415 | 3,345,941 | May 17, 2017, 08:52 PM |
| Neff Thomas B | Chief Executive Officer | May 16, 2017 | Sale | $27.67 | 418 | 11,566 | 139,218 | May 17, 2017, 08:52 PM |
| Neff Thomas B | Chief Executive Officer | May 16, 2017 | Sale | $27.64 | 18,900 | 522,396 | 3,327,041 | May 17, 2017, 08:52 PM |
| Neff Thomas B | Chief Executive Officer | May 15, 2017 | Sale | $27.81 | 418 | 11,625 | 139,636 | May 17, 2017, 08:52 PM |
| Neff Thomas B | Chief Executive Officer | May 15, 2017 | Sale | $27.75 | 18,900 | 524,475 | 3,327,041 | May 17, 2017, 08:52 PM |
| Yu K Peony | Chief Medical Officer | May 10, 2017 | Sale | $26.38 | 5,000 | 131,890 | 227,346 | May 12, 2017, 06:22 PM |
| Yu K Peony | Chief Medical Officer | Apr 25, 2017 | Option Exercise | $14.57 | 5,000 | 72,875 | 236,046 | Apr 27, 2017, 08:45 PM |
| Yu K Peony | Chief Medical Officer | Apr 25, 2017 | Sale | $28.00 | 5,000 | 140,000 | 231,046 | Apr 27, 2017, 08:45 PM |
| Cotroneo Pat | VP, Finance and CFO | Apr 25, 2017 | Option Exercise | $2.35 | 6,500 | 15,275 | 164,405 | Apr 27, 2017, 08:44 PM |
| Cotroneo Pat | VP, Finance and CFO | Apr 25, 2017 | Sale | $28.00 | 6,500 | 182,000 | 157,905 | Apr 27, 2017, 08:44 PM |
| Neff Thomas B | Chief Executive Officer | Apr 25, 2017 | Option Exercise | $3.13 | 18,900 | 59,145 | 3,345,941 | Apr 26, 2017, 07:31 PM |
| Neff Thomas B | Chief Executive Officer | Apr 24, 2017 | Option Exercise | $4.03 | 18,900 | 76,073 | 3,345,941 | Apr 26, 2017, 07:31 PM |
| Neff Thomas B | Chief Executive Officer | Apr 25, 2017 | Sale | $27.49 | 18,900 | 519,561 | 3,327,041 | Apr 26, 2017, 07:31 PM |
| Neff Thomas B | Chief Executive Officer | Apr 24, 2017 | Sale | $26.45 | 418 | 11,056 | 140,472 | Apr 26, 2017, 07:31 PM |
| Neff Thomas B | Chief Executive Officer | Apr 24, 2017 | Sale | $26.35 | 18,900 | 498,015 | 3,327,041 | Apr 26, 2017, 07:31 PM |
| Neff Thomas B | Chief Executive Officer | Apr 25, 2017 | Sale | $27.67 | 418 | 11,566 | 140,054 | Apr 26, 2017, 07:31 PM |
| Kurkijarvi Kalevi | Director | Apr 17, 2017 | Sale | $25.25 | 2,000 | 50,500 | 38,000 | Apr 19, 2017, 06:11 PM |
| Neff Thomas B | Chief Executive Officer | Apr 13, 2017 | Option Exercise | $4.03 | 18,900 | 76,073 | 3,345,941 | Apr 14, 2017, 06:06 PM |
| Neff Thomas B | Chief Executive Officer | Apr 12, 2017 | Option Exercise | $4.03 | 18,900 | 76,073 | 3,345,941 | Apr 14, 2017, 06:06 PM |
| Neff Thomas B | Chief Executive Officer | Apr 13, 2017 | Sale | $24.91 | 18,900 | 470,799 | 3,327,041 | Apr 14, 2017, 06:06 PM |
| Neff Thomas B | Chief Executive Officer | Apr 12, 2017 | Sale | $24.57 | 418 | 10,270 | 141,308 | Apr 14, 2017, 06:06 PM |
| Neff Thomas B | Chief Executive Officer | Apr 12, 2017 | Sale | $24.67 | 18,900 | 466,172 | 3,329,341 | Apr 14, 2017, 06:06 PM |
| Neff Thomas B | Chief Executive Officer | Apr 13, 2017 | Sale | $24.95 | 418 | 10,429 | 140,890 | Apr 14, 2017, 06:06 PM |
| Neff Thomas B | Chief Executive Officer | Apr 04, 2017 | Option Exercise | $4.03 | 18,900 | 76,073 | 3,345,941 | Apr 04, 2017, 09:39 PM |
| Neff Thomas B | Chief Executive Officer | Apr 03, 2017 | Option Exercise | $4.03 | 18,900 | 76,073 | 3,345,941 | Apr 04, 2017, 09:39 PM |
| Neff Thomas B | Chief Executive Officer | Apr 04, 2017 | Sale | $23.85 | 18,900 | 450,765 | 3,327,041 | Apr 04, 2017, 09:39 PM |
| Neff Thomas B | Chief Executive Officer | Apr 03, 2017 | Sale | $23.92 | 418 | 9,999 | 142,144 | Apr 04, 2017, 09:39 PM |
| Neff Thomas B | Chief Executive Officer | Apr 03, 2017 | Sale | $23.99 | 18,900 | 453,411 | 3,327,041 | Apr 04, 2017, 09:39 PM |
| Neff Thomas B | Chief Executive Officer | Apr 04, 2017 | Sale | $23.80 | 418 | 9,948 | 141,726 | Apr 04, 2017, 09:39 PM |
| Neff Thomas B | Chief Executive Officer | Mar 21, 2017 | Option Exercise | $4.03 | 18,900 | 76,073 | 3,345,941 | Mar 22, 2017, 06:36 PM |
| Neff Thomas B | Chief Executive Officer | Mar 20, 2017 | Option Exercise | $4.03 | 18,900 | 76,073 | 3,345,941 | Mar 22, 2017, 06:36 PM |
| Neff Thomas B | Chief Executive Officer | Mar 20, 2017 | Sale | $24.92 | 418 | 10,417 | 142,980 | Mar 22, 2017, 06:36 PM |
| Neff Thomas B | Chief Executive Officer | Mar 20, 2017 | Sale | $24.88 | 18,900 | 470,232 | 3,327,041 | Mar 22, 2017, 06:36 PM |
| Neff Thomas B | Chief Executive Officer | Mar 21, 2017 | Sale | $23.58 | 418 | 9,856 | 142,562 | Mar 22, 2017, 06:36 PM |
| Neff Thomas B | Chief Executive Officer | Mar 21, 2017 | Sale | $23.80 | 18,900 | 449,800 | 3,332,141 | Mar 22, 2017, 06:36 PM |
| Yu K Peony | Chief Medical Officer | Mar 14, 2017 | Sale | $25.41 | 7,851 | 199,458 | 234,246 | Mar 16, 2017, 07:31 PM |
| Neff Thomas B | Chief Executive Officer | Mar 14, 2017 | Option Exercise | $4.03 | 10,858 | 43,703 | 3,353,983 | Mar 16, 2017, 07:29 PM |
| Neff Thomas B | Chief Executive Officer | Mar 15, 2017 | Option Exercise | $4.03 | 10,858 | 43,703 | 3,345,941 | Mar 16, 2017, 07:29 PM |
| Neff Thomas B | Chief Executive Officer | Mar 14, 2017 | Sale | $25.02 | 418 | 10,458 | 143,816 | Mar 16, 2017, 07:29 PM |
| Neff Thomas B | Chief Executive Officer | Mar 14, 2017 | Sale | $25.06 | 18,900 | 473,631 | 3,335,583 | Mar 16, 2017, 07:29 PM |
| Neff Thomas B | Chief Executive Officer | Mar 15, 2017 | Sale | $25.07 | 19,318 | 484,382 | 3,327,041 | Mar 16, 2017, 07:29 PM |
| Cotroneo Pat | VP, Finance and CFO | Mar 10, 2017 | Sale | $25.30 | 7,851 | 198,630 | 157,905 | Mar 14, 2017, 07:43 PM |
| Yu K Peony | Chief Medical Officer | Mar 06, 2017 | Option Exercise | $25.35 | 4,727 | 119,829 | 197,721 | Mar 08, 2017, 08:34 PM |
| Neff Thomas B | Chief Executive Officer | Mar 06, 2017 | Option Exercise | $25.35 | 17,736 | 449,608 | 3,237,425 | Mar 08, 2017, 08:31 PM |
| Cotroneo Pat | VP, Finance and CFO | Mar 06, 2017 | Option Exercise | $25.35 | 4,727 | 119,829 | 127,521 | Mar 08, 2017, 08:29 PM |
| Cotroneo Pat | VP, Finance and CFO | Mar 02, 2017 | Option Exercise | $2.35 | 5,600 | 13,160 | 137,848 | Mar 06, 2017, 06:14 PM |
| Cotroneo Pat | VP, Finance and CFO | Mar 01, 2017 | Option Exercise | $2.35 | 900 | 2,115 | 133,148 | Mar 06, 2017, 06:14 PM |
| Cotroneo Pat | VP, Finance and CFO | Mar 02, 2017 | Sale | $26.00 | 5,600 | 145,600 | 132,248 | Mar 06, 2017, 06:14 PM |
| Cotroneo Pat | VP, Finance and CFO | Mar 01, 2017 | Sale | $26.00 | 900 | 23,400 | 132,248 | Mar 06, 2017, 06:14 PM |
| Kurkijarvi Kalevi | Director | Feb 16, 2017 | Sale | $24.45 | 2,000 | 48,900 | 40,000 | Feb 17, 2017, 04:59 PM |
| Neff Thomas B | Chief Executive Officer | Feb 14, 2017 | Option Exercise | $4.03 | 18,900 | 76,073 | 3,274,061 | Feb 15, 2017, 07:59 PM |
| Neff Thomas B | Chief Executive Officer | Feb 13, 2017 | Option Exercise | $4.03 | 18,900 | 76,073 | 3,274,061 | Feb 15, 2017, 07:59 PM |
| Neff Thomas B | Chief Executive Officer | Feb 14, 2017 | Sale | $23.90 | 18,900 | 451,710 | 3,255,161 | Feb 15, 2017, 07:59 PM |
| Neff Thomas B | Chief Executive Officer | Feb 13, 2017 | Sale | $24.01 | 418 | 10,036 | 144,652 | Feb 15, 2017, 07:59 PM |
| Neff Thomas B | Chief Executive Officer | Feb 13, 2017 | Sale | $23.97 | 18,900 | 453,033 | 3,255,161 | Feb 15, 2017, 07:59 PM |
| Neff Thomas B | Chief Executive Officer | Feb 14, 2017 | Sale | $23.89 | 418 | 9,986 | 144,234 | Feb 15, 2017, 07:59 PM |
| Neff Thomas B | Chief Executive Officer | Feb 09, 2017 | Option Exercise | $4.03 | 14,091 | 56,716 | 3,274,060 | Feb 10, 2017, 07:24 PM |
| Neff Thomas B | Chief Executive Officer | Feb 08, 2017 | Option Exercise | $4.03 | 14,091 | 56,716 | 3,278,868 | Feb 10, 2017, 07:24 PM |
| Neff Thomas B | Chief Executive Officer | Feb 08, 2017 | Sale | $23.03 | 18,899 | 435,244 | 3,259,969 | Feb 10, 2017, 07:24 PM |
| Neff Thomas B | Chief Executive Officer | Feb 09, 2017 | Sale | $23.89 | 18,899 | 451,497 | 3,255,161 | Feb 10, 2017, 07:24 PM |
| Neff Thomas B | Chief Executive Officer | Jan 26, 2017 | Option Exercise | $4.03 | 14,091 | 56,716 | 3,288,484 | Jan 27, 2017, 06:50 PM |
| Neff Thomas B | Chief Executive Officer | Jan 27, 2017 | Option Exercise | $4.03 | 14,091 | 56,716 | 3,283,676 | Jan 27, 2017, 06:50 PM |
| Neff Thomas B | Chief Executive Officer | Jan 27, 2017 | Sale | $23.16 | 18,899 | 437,701 | 3,264,777 | Jan 27, 2017, 06:50 PM |
| Neff Thomas B | Chief Executive Officer | Jan 26, 2017 | Sale | $23.42 | 18,899 | 442,615 | 3,269,585 | Jan 27, 2017, 06:50 PM |
| Kurkijarvi Kalevi | Director | Jan 19, 2017 | Sale | $24.90 | 2,000 | 49,800 | 42,000 | Jan 20, 2017, 08:34 PM |
| Cotroneo Pat | VP, Finance and CFO | Jan 11, 2017 | Option Exercise | $2.35 | 6,500 | 15,275 | 138,748 | Jan 13, 2017, 05:29 PM |
| Cotroneo Pat | VP, Finance and CFO | Jan 11, 2017 | Sale | $24.00 | 6,500 | 156,000 | 132,248 | Jan 13, 2017, 05:29 PM |
| Neff Thomas B | Chief Executive Officer | Jan 11, 2017 | Option Exercise | $4.03 | 14,091 | 56,716 | 3,298,100 | Jan 13, 2017, 05:27 PM |
| Neff Thomas B | Chief Executive Officer | Jan 12, 2017 | Option Exercise | $4.03 | 14,091 | 56,716 | 3,293,292 | Jan 13, 2017, 05:27 PM |
| Neff Thomas B | Chief Executive Officer | Jan 12, 2017 | Sale | $24.20 | 18,899 | 457,324 | 3,283,592 | Jan 13, 2017, 05:27 PM |
| Neff Thomas B | Chief Executive Officer | Jan 11, 2017 | Sale | $23.50 | 18,899 | 444,198 | 3,287,700 | Jan 13, 2017, 05:27 PM |
| Yu K Peony | Chief Medical Officer | Jan 10, 2017 | Sale | $23.56 | 5,000 | 117,800 | 202,448 | Jan 12, 2017, 06:12 PM |
| Neff Thomas B | Chief Executive Officer | Dec 28, 2016 | Option Exercise | $4.03 | 14,089 | 56,708 | 3,302,908 | Dec 29, 2016, 06:09 PM |
| Neff Thomas B | Chief Executive Officer | Dec 27, 2016 | Option Exercise | $4.03 | 14,091 | 56,716 | 3,307,718 | Dec 29, 2016, 06:09 PM |
| Neff Thomas B | Chief Executive Officer | Dec 28, 2016 | Sale | $20.69 | 18,899 | 391,020 | 3,284,009 | Dec 29, 2016, 06:09 PM |
| Neff Thomas B | Chief Executive Officer | Dec 27, 2016 | Sale | $20.79 | 18,899 | 392,910 | 3,288,819 | Dec 29, 2016, 06:09 PM |
| RIGGS RORY B | Director | Dec 16, 2016 | Sale | $20.87 | 20,000 | 417,310 | 460,200 | Dec 16, 2016, 06:54 PM |
| Yu K Peony | Chief Medical Officer | Dec 14, 2016 | Sale | $20.65 | 2,344 | 48,404 | 207,448 | Dec 16, 2016, 06:52 PM |
| Cotroneo Pat | VP, Finance and CFO | Dec 12, 2016 | Sale | $22.05 | 2,344 | 51,685 | 132,248 | Dec 14, 2016, 08:01 PM |
| Neff Thomas B | Chief Executive Officer | Dec 13, 2016 | Option Exercise | $4.03 | 14,091 | 56,716 | 3,312,526 | Dec 14, 2016, 08:00 PM |
| Neff Thomas B | Chief Executive Officer | Dec 12, 2016 | Option Exercise | $4.03 | 14,091 | 56,716 | 3,317,334 | Dec 14, 2016, 08:00 PM |
| Neff Thomas B | Chief Executive Officer | Dec 13, 2016 | Sale | $21.00 | 18,899 | 396,850 | 3,295,752 | Dec 14, 2016, 08:00 PM |
| Neff Thomas B | Chief Executive Officer | Dec 12, 2016 | Sale | $21.48 | 18,899 | 405,978 | 3,299,335 | Dec 14, 2016, 08:00 PM |
| Yu K Peony | Chief Medical Officer | Dec 01, 2016 | Option Exercise | $20.55 | 1,410 | 28,975 | 209,792 | Dec 02, 2016, 08:46 PM |
| Neff Thomas B | Chief Executive Officer | Dec 01, 2016 | Option Exercise | $20.55 | 4,689 | 96,359 | 3,303,243 | Dec 02, 2016, 08:43 PM |
| Cotroneo Pat | VP, Finance and CFO | Dec 01, 2016 | Option Exercise | $20.55 | 1,410 | 28,975 | 134,592 | Dec 02, 2016, 08:42 PM |
| Neff Thomas B | Chief Executive Officer | Nov 28, 2016 | Option Exercise | $4.03 | 14,091 | 56,716 | 3,331,639 | Nov 30, 2016, 06:40 PM |
| Neff Thomas B | Chief Executive Officer | Nov 29, 2016 | Option Exercise | $4.03 | 14,091 | 56,716 | 3,326,831 | Nov 30, 2016, 06:40 PM |
| Neff Thomas B | Chief Executive Officer | Nov 29, 2016 | Sale | $22.86 | 18,899 | 432,031 | 3,307,932 | Nov 30, 2016, 06:40 PM |
| Neff Thomas B | Chief Executive Officer | Nov 28, 2016 | Sale | $22.74 | 18,899 | 429,763 | 3,312,740 | Nov 30, 2016, 06:40 PM |
| KEARNS THOMAS F JR | Director | Nov 18, 2016 | Option Exercise | $4.03 | 13,000 | 52,325 | 173,564 | Nov 18, 2016, 07:11 PM |
| KEARNS THOMAS F JR | Director | Nov 17, 2016 | Option Exercise | $4.03 | 5,000 | 20,125 | 165,564 | Nov 18, 2016, 07:11 PM |
| KEARNS THOMAS F JR | Director | Nov 18, 2016 | Sale | $22.47 | 13,000 | 292,132 | 160,564 | Nov 18, 2016, 07:11 PM |
| KEARNS THOMAS F JR | Director | Nov 17, 2016 | Sale | $22.21 | 5,000 | 111,028 | 160,564 | Nov 18, 2016, 07:11 PM |
| Neff Thomas B | Chief Executive Officer | Nov 17, 2016 | Option Exercise | $4.03 | 14,091 | 56,716 | 3,336,447 | Nov 18, 2016, 05:10 PM |
| Neff Thomas B | Chief Executive Officer | Nov 16, 2016 | Option Exercise | $4.03 | 14,091 | 56,716 | 3,341,255 | Nov 18, 2016, 05:10 PM |
| Neff Thomas B | Chief Executive Officer | Nov 16, 2016 | Sale | $22.36 | 18,899 | 422,582 | 3,322,356 | Nov 18, 2016, 05:10 PM |
| Neff Thomas B | Chief Executive Officer | Nov 17, 2016 | Sale | $22.22 | 18,899 | 419,936 | 3,317,548 | Nov 18, 2016, 05:10 PM |
| Yu K Peony | Chief Medical Officer | Nov 08, 2016 | Option Exercise | $4.91 | 4,700 | 23,065 | 211,202 | Nov 08, 2016, 08:03 PM |
| Cotroneo Pat | VP, Finance and CFO | Nov 04, 2016 | Option Exercise | $2.90 | 1,643 | 4,765 | 136,002 | Nov 07, 2016, 08:15 PM |
| Neff Thomas B | Chief Executive Officer | Oct 31, 2016 | Option Exercise | $4.03 | 14,091 | 56,716 | 3,350,871 | Nov 01, 2016, 07:58 PM |
| Neff Thomas B | Chief Executive Officer | Nov 01, 2016 | Option Exercise | $4.03 | 14,091 | 56,716 | 3,346,063 | Nov 01, 2016, 07:58 PM |
| Neff Thomas B | Chief Executive Officer | Nov 01, 2016 | Sale | $16.84 | 18,899 | 318,259 | 3,327,164 | Nov 01, 2016, 07:58 PM |
| Neff Thomas B | Chief Executive Officer | Oct 31, 2016 | Sale | $16.67 | 18,899 | 315,046 | 3,331,972 | Nov 01, 2016, 07:58 PM |
| Neff Thomas B | Chief Executive Officer | Oct 19, 2016 | Option Exercise | $4.03 | 14,091 | 56,716 | 3,355,679 | Oct 19, 2016, 09:00 PM |
| Neff Thomas B | Chief Executive Officer | Oct 18, 2016 | Option Exercise | $4.03 | 14,091 | 56,716 | 3,360,487 | Oct 19, 2016, 09:00 PM |
| Neff Thomas B | Chief Executive Officer | Oct 19, 2016 | Sale | $17.56 | 18,899 | 331,866 | 3,336,780 | Oct 19, 2016, 09:00 PM |
| Neff Thomas B | Chief Executive Officer | Oct 18, 2016 | Sale | $17.94 | 18,899 | 339,048 | 3,341,588 | Oct 19, 2016, 09:00 PM |
| Neff Thomas B | Chief Executive Officer | Oct 04, 2016 | Option Exercise | $4.03 | 14,091 | 56,716 | 3,365,295 | Oct 05, 2016, 07:18 PM |
| Neff Thomas B | Chief Executive Officer | Oct 03, 2016 | Option Exercise | $4.03 | 14,091 | 56,716 | 3,370,103 | Oct 05, 2016, 07:18 PM |
| Neff Thomas B | Chief Executive Officer | Oct 03, 2016 | Sale | $20.55 | 18,899 | 388,374 | 3,351,204 | Oct 05, 2016, 07:18 PM |
| Neff Thomas B | Chief Executive Officer | Oct 04, 2016 | Sale | $20.67 | 18,899 | 390,642 | 3,346,396 | Oct 05, 2016, 07:18 PM |
| Neff Thomas B | Chief Executive Officer | Sep 20, 2016 | Option Exercise | $4.03 | 14,091 | 56,716 | 3,379,719 | Sep 22, 2016, 07:53 PM |
| Neff Thomas B | Chief Executive Officer | Sep 21, 2016 | Option Exercise | $4.03 | 14,091 | 56,716 | 3,374,911 | Sep 22, 2016, 07:53 PM |
| Neff Thomas B | Chief Executive Officer | Sep 21, 2016 | Sale | $21.52 | 18,899 | 406,706 | 3,356,012 | Sep 22, 2016, 07:53 PM |
| Neff Thomas B | Chief Executive Officer | Sep 20, 2016 | Sale | $21.80 | 18,899 | 411,998 | 3,360,820 | Sep 22, 2016, 07:53 PM |
| Yu K Peony | Chief Medical Officer | Sep 14, 2016 | Sale | $18.66 | 2,345 | 43,758 | 206,502 | Sep 15, 2016, 06:51 PM |
| Cotroneo Pat | VP, Finance and CFO | Sep 12, 2016 | Sale | $18.22 | 2,345 | 42,726 | 134,359 | Sep 14, 2016, 06:33 PM |
| Neff Thomas B | Chief Executive Officer | Sep 09, 2016 | Option Exercise | $4.03 | 14,091 | 56,716 | 3,384,527 | Sep 09, 2016, 07:45 PM |
| Neff Thomas B | Chief Executive Officer | Sep 08, 2016 | Option Exercise | $4.03 | 14,091 | 56,716 | 3,389,335 | Sep 09, 2016, 07:45 PM |
| Neff Thomas B | Chief Executive Officer | Sep 09, 2016 | Sale | $18.83 | 18,899 | 355,868 | 3,365,628 | Sep 09, 2016, 07:45 PM |
| Neff Thomas B | Chief Executive Officer | Sep 08, 2016 | Sale | $19.14 | 18,899 | 361,727 | 3,370,436 | Sep 09, 2016, 07:45 PM |
| Neff Thomas B | Chief Executive Officer | Sep 01, 2016 | Option Exercise | $17.33 | 4,688 | 81,243 | 3,375,244 | Sep 02, 2016, 07:44 PM |
| Yu K Peony | Chief Medical Officer | Sep 01, 2016 | Option Exercise | $17.33 | 1,410 | 24,435 | 208,847 | Sep 02, 2016, 07:43 PM |
| Cotroneo Pat | VP, Finance and CFO | Sep 01, 2016 | Option Exercise | $17.33 | 1,410 | 24,435 | 136,704 | Sep 02, 2016, 07:42 PM |
| Neff Thomas B | Chief Executive Officer | Aug 25, 2016 | Option Exercise | $4.03 | 14,091 | 56,716 | 3,403,639 | Aug 29, 2016, 05:59 PM |
| Neff Thomas B | Chief Executive Officer | Aug 26, 2016 | Option Exercise | $4.03 | 14,091 | 56,716 | 3,398,831 | Aug 29, 2016, 05:59 PM |
| Neff Thomas B | Chief Executive Officer | Aug 26, 2016 | Sale | $17.81 | 18,899 | 336,591 | 3,379,932 | Aug 29, 2016, 05:59 PM |
| Neff Thomas B | Chief Executive Officer | Aug 25, 2016 | Sale | $17.78 | 18,899 | 336,114 | 3,385,940 | Aug 29, 2016, 05:59 PM |
| Neff Thomas B | Chief Executive Officer | Jul 27, 2016 | Option Exercise | $4.03 | 14,091 | 56,716 | 3,408,447 | Jul 28, 2016, 06:49 PM |
| Neff Thomas B | Chief Executive Officer | Jul 26, 2016 | Option Exercise | $4.03 | 14,091 | 56,716 | 3,413,255 | Jul 28, 2016, 06:49 PM |
| Neff Thomas B | Chief Executive Officer | Jul 27, 2016 | Sale | $18.41 | 18,899 | 347,885 | 3,389,548 | Jul 28, 2016, 06:49 PM |
| Neff Thomas B | Chief Executive Officer | Jul 26, 2016 | Sale | $18.34 | 18,899 | 346,663 | 3,398,456 | Jul 28, 2016, 06:49 PM |
| Neff Thomas B | Chief Executive Officer | Jul 13, 2016 | Sale | $17.18 | 13,500 | 231,984 | 3,409,964 | Jul 14, 2016, 08:07 PM |
| Neff Thomas B | Chief Executive Officer | Jul 12, 2016 | Sale | $17.81 | 13,500 | 240,435 | 3,412,664 | Jul 14, 2016, 08:07 PM |
| Neff Thomas B | Chief Executive Officer | Jun 29, 2016 | Sale | $16.17 | 13,500 | 218,295 | 3,426,164 | Jun 30, 2016, 04:50 PM |
| Neff Thomas B | Chief Executive Officer | Jun 28, 2016 | Sale | $15.87 | 13,500 | 214,279 | 3,439,764 | Jun 30, 2016, 04:50 PM |
| Neff Thomas B | Chief Executive Officer | Jun 15, 2016 | Sale | $16.49 | 13,500 | 222,615 | 3,453,164 | Jun 16, 2016, 06:50 PM |
| Neff Thomas B | Chief Executive Officer | Jun 14, 2016 | Sale | $16.47 | 13,500 | 222,345 | 3,466,664 | Jun 16, 2016, 06:50 PM |
| Cotroneo Pat | VP, Finance and CFO | Jun 15, 2016 | Sale | $16.49 | 1,796 | 29,616 | 138,114 | Jun 16, 2016, 06:47 PM |
| Yu K Peony | Chief Medical Officer | Jun 10, 2016 | Sale | $17.96 | 2,344 | 42,098 | 210,257 | Jun 14, 2016, 07:25 PM |
| Yu K Peony | Chief Medical Officer | Jun 01, 2016 | Option Exercise | $18.89 | 1,410 | 26,635 | 212,601 | Jun 03, 2016, 05:55 PM |
| Neff Thomas B | Chief Executive Officer | Jun 01, 2016 | Option Exercise | $18.89 | 4,689 | 88,575 | 3,507,164 | Jun 03, 2016, 05:54 PM |
| Neff Thomas B | Chief Executive Officer | Jun 03, 2016 | Sale | $18.81 | 13,500 | 253,935 | 3,480,164 | Jun 03, 2016, 05:54 PM |
| Neff Thomas B | Chief Executive Officer | Jun 02, 2016 | Sale | $19.16 | 13,500 | 258,660 | 3,493,664 | Jun 03, 2016, 05:54 PM |
| Cotroneo Pat | VP, Finance and CFO | Jun 01, 2016 | Option Exercise | $18.89 | 1,958 | 36,987 | 139,910 | Jun 03, 2016, 05:53 PM |
| Neff Thomas B | Chief Executive Officer | May 19, 2016 | Sale | $17.48 | 13,500 | 236,044 | 3,526,053 | May 20, 2016, 07:46 PM |
| Neff Thomas B | Chief Executive Officer | May 20, 2016 | Sale | $17.88 | 13,500 | 241,380 | 3,511,853 | May 20, 2016, 07:46 PM |
| Yu K Peony | Chief Medical Officer | May 16, 2016 | Sale | $17.60 | 6,107 | 107,483 | 214,011 | May 18, 2016, 05:56 PM |
| Cotroneo Pat | VP, Finance and CFO | May 16, 2016 | Sale | $17.60 | 6,107 | 107,483 | 141,868 | May 18, 2016, 05:55 PM |
| Neff Thomas B | Chief Executive Officer | May 03, 2016 | Sale | $17.61 | 13,500 | 237,735 | 3,538,853 | May 03, 2016, 07:01 PM |
| Neff Thomas B | Chief Executive Officer | May 02, 2016 | Sale | $17.95 | 13,500 | 242,325 | 3,552,353 | May 03, 2016, 07:01 PM |
| Neff Thomas B | Chief Executive Officer | Apr 20, 2016 | Sale | $19.75 | 13,500 | 266,625 | 3,565,853 | Apr 20, 2016, 09:15 PM |
| Neff Thomas B | Chief Executive Officer | Apr 19, 2016 | Sale | $20.21 | 13,500 | 272,835 | 3,579,353 | Apr 20, 2016, 09:15 PM |
| Neff Thomas B | Chief Executive Officer | Apr 05, 2016 | Sale | $20.93 | 13,500 | 282,493 | 3,596,363 | Apr 05, 2016, 08:41 PM |
| Neff Thomas B | Chief Executive Officer | Apr 04, 2016 | Sale | $21.30 | 13,500 | 287,550 | 3,606,353 | Apr 05, 2016, 08:41 PM |
| VALONE FRANK H MD | Chief Medical Officer | Apr 01, 2016 | Option Exercise | $3.92 | 10,750 | 42,194 | 115,434 | Apr 04, 2016, 06:53 PM |
| VALONE FRANK H MD | Chief Medical Officer | Apr 01, 2016 | Sale | $21.11 | 10,750 | 226,941 | 104,884 | Apr 04, 2016, 06:53 PM |
| Neff Thomas B | Chief Executive Officer | Mar 22, 2016 | Sale | $18.87 | 13,500 | 254,745 | 3,619,853 | Mar 22, 2016, 08:45 PM |
| Neff Thomas B | Chief Executive Officer | Mar 21, 2016 | Sale | $18.60 | 13,500 | 251,127 | 3,633,453 | Mar 22, 2016, 08:45 PM |
| Tamura Toshinari | Director | Mar 16, 2016 | Option Exercise | $2.63 | 48,000 | 126,000 | 48,000 | Mar 17, 2016, 05:56 PM |
| Neff Thomas B | Chief Executive Officer | Mar 08, 2016 | Sale | $19.12 | 13,500 | 258,144 | 3,649,053 | Mar 08, 2016, 06:16 PM |
| Neff Thomas B | Chief Executive Officer | Mar 07, 2016 | Sale | $20.11 | 13,500 | 271,469 | 3,667,175 | Mar 08, 2016, 06:16 PM |
| Yu K Peony | VP, Clinical Development | Mar 03, 2016 | Option Exercise | $18.77 | 3,660 | 68,698 | 218,729 | Mar 04, 2016, 06:31 PM |
| VALONE FRANK H MD | Chief Medical Officer | Mar 03, 2016 | Option Exercise | $18.77 | 3,921 | 73,597 | 104,684 | Mar 04, 2016, 06:15 PM |
| Neff Thomas B | Chief Executive Officer | Mar 03, 2016 | Option Exercise | $18.77 | 8,554 | 160,559 | 3,673,853 | Mar 04, 2016, 06:12 PM |
| Cotroneo Pat | VP, Finance and CFO | Mar 03, 2016 | Option Exercise | $18.77 | 3,660 | 68,698 | 146,586 | Mar 04, 2016, 06:11 PM |
| VALONE FRANK H MD | Chief Medical Officer | Mar 01, 2016 | Option Exercise | $3.62 | 10,750 | 38,895 | 119,355 | Mar 03, 2016, 07:09 PM |
| VALONE FRANK H MD | Chief Medical Officer | Mar 01, 2016 | Sale | $16.84 | 10,750 | 181,040 | 112,095 | Mar 03, 2016, 07:09 PM |
| Neff Thomas B | Chief Executive Officer | Feb 23, 2016 | Sale | $18.40 | 13,500 | 248,400 | 3,685,107 | Feb 24, 2016, 09:17 PM |
| Neff Thomas B | Chief Executive Officer | Feb 22, 2016 | Sale | $19.81 | 13,500 | 267,450 | 3,596,207 | Feb 24, 2016, 09:17 PM |
| VALONE FRANK H MD | Chief Medical Officer | Feb 16, 2016 | Option Exercise | $3.36 | 10,750 | 36,130 | 107,590 | Feb 18, 2016, 05:17 PM |
| VALONE FRANK H MD | Chief Medical Officer | Feb 16, 2016 | Sale | $18.41 | 10,750 | 197,943 | 96,840 | Feb 18, 2016, 05:17 PM |
| Neff Thomas B | Chief Executive Officer | Feb 09, 2016 | Sale | $15.14 | 13,500 | 204,380 | 3,624,507 | Feb 11, 2016, 08:13 PM |
| Neff Thomas B | Chief Executive Officer | Feb 10, 2016 | Sale | $15.48 | 13,500 | 208,980 | 3,609,407 | Feb 11, 2016, 08:13 PM |
| Yu K Peony | VP, Clinical Development | Feb 05, 2016 | Option Exercise | $4.55 | 10,500 | 47,775 | 187,095 | Feb 09, 2016, 07:32 PM |
| Cotroneo Pat | VP, Finance and CFO | Feb 05, 2016 | Option Exercise | $2.90 | 3,627 | 10,518 | 114,952 | Feb 09, 2016, 07:30 PM |
| Neff Thomas B | Chief Executive Officer | Jan 29, 2016 | Sale | $19.61 | 13,500 | 264,743 | 3,637,107 | Jan 29, 2016, 07:44 PM |
| Neff Thomas B | Chief Executive Officer | Jan 28, 2016 | Sale | $19.21 | 13,500 | 259,272 | 3,650,807 | Jan 29, 2016, 07:44 PM |
| Cotroneo Pat | VP, Finance and CFO | Jan 21, 2016 | Option Exercise | $2.90 | 4,000 | 11,600 | 111,325 | Jan 22, 2016, 07:19 PM |
| KEARNS THOMAS F JR | Director | Jan 21, 2016 | Sale | $22.08 | 1,572 | 34,710 | 160,564 | Jan 22, 2016, 07:18 PM |
| VALONE FRANK H MD | Chief Medical Officer | Jan 22, 2016 | Option Exercise | $2.90 | 10,000 | 29,000 | 96,840 | Jan 22, 2016, 07:17 PM |
| Neff Thomas B | Chief Executive Officer | Jan 14, 2016 | Sale | $23.41 | 13,500 | 316,061 | 3,671,107 | Jan 15, 2016, 07:08 PM |
| Neff Thomas B | Chief Executive Officer | Jan 13, 2016 | Sale | $23.97 | 13,500 | 323,622 | 3,680,807 | Jan 15, 2016, 07:08 PM |
| Routti Jorma | Director | Dec 28, 2015 | Option Exercise | $3.22 | 20,000 | 64,300 | 127,840 | Dec 30, 2015, 04:46 PM |
| KEARNS THOMAS F JR | Director | Dec 24, 2015 | Sale | $30.81 | 3,900 | 120,159 | 162,136 | Dec 28, 2015, 06:41 PM |
| KEARNS THOMAS F JR | Director | Dec 23, 2015 | Sale | $30.94 | 3,900 | 120,666 | 166,036 | Dec 28, 2015, 06:41 PM |
| Neff Thomas B | Chief Executive Officer | Dec 23, 2015 | Sale | $30.93 | 13,500 | 417,555 | 3,690,407 | Dec 23, 2015, 07:27 PM |
| Neff Thomas B | Chief Executive Officer | Dec 22, 2015 | Sale | $29.27 | 13,500 | 395,148 | 3,704,107 | Dec 23, 2015, 07:27 PM |
| Cotroneo Pat | VP, Finance and CFO | Dec 15, 2015 | Sale | $28.95 | 837 | 24,231 | 107,325 | Dec 17, 2015, 06:40 PM |
| Yu K Peony | VP, Clinical Development | Dec 10, 2015 | Sale | $28.96 | 1,093 | 31,653 | 176,595 | Dec 11, 2015, 08:41 PM |
| Neff Thomas B | Chief Executive Officer | Dec 11, 2015 | Sale | $29.22 | 13,500 | 394,502 | 3,720,207 | Dec 11, 2015, 08:40 PM |
| Neff Thomas B | Chief Executive Officer | Dec 10, 2015 | Sale | $29.95 | 13,500 | 404,313 | 3,737,807 | Dec 11, 2015, 08:40 PM |
| MADERO MIGUEL | Director | Dec 08, 2015 | Option Exercise | $7.47 | 84,000 | 627,240 | 96,000 | Dec 10, 2015, 05:42 PM |
| MADERO MIGUEL | Director | Dec 08, 2015 | Sale | $30.49 | 40,386 | 1,231,369 | 55,614 | Dec 10, 2015, 05:42 PM |
| Rosenkranz Roberto Pedro | Director | Dec 04, 2015 | Option Exercise | $4.21 | 7,000 | 29,450 | 42,000 | Dec 07, 2015, 06:43 PM |
| Yu K Peony | VP, Clinical Development | Dec 01, 2015 | Option Exercise | $29.88 | 657 | 19,631 | 177,688 | Dec 03, 2015, 08:36 PM |
| VALONE FRANK H MD | Chief Medical Officer | Dec 01, 2015 | Option Exercise | $29.88 | 704 | 21,036 | 93,340 | Dec 03, 2015, 08:33 PM |
| Neff Thomas B | Chief Executive Officer | Dec 01, 2015 | Option Exercise | $29.88 | 2,282 | 68,186 | 3,744,407 | Dec 03, 2015, 08:32 PM |
| Cotroneo Pat | VP, Finance and CFO | Dec 01, 2015 | Option Exercise | $29.88 | 913 | 27,280 | 106,862 | Dec 03, 2015, 08:31 PM |
| Cotroneo Pat | VP, Finance and CFO | Dec 03, 2015 | Option Exercise | $2.90 | 1,300 | 3,770 | 108,162 | Dec 03, 2015, 08:31 PM |
| Yu K Peony | VP, Clinical Development | Nov 30, 2015 | Sale | $30.00 | 4,656 | 139,680 | 178,345 | Nov 30, 2015, 07:28 PM |
| Yu K Peony | VP, Clinical Development | Nov 25, 2015 | Sale | $30.00 | 344 | 10,320 | 183,001 | Nov 30, 2015, 07:28 PM |
| Cotroneo Pat | VP, Finance and CFO | Nov 25, 2015 | Option Exercise | $2.35 | 5,000 | 11,750 | 112,775 | Nov 30, 2015, 07:27 PM |
| Cotroneo Pat | VP, Finance and CFO | Nov 25, 2015 | Sale | $30.00 | 5,000 | 150,000 | 107,775 | Nov 30, 2015, 07:27 PM |
| Neff Thomas B | Chief Executive Officer | Nov 24, 2015 | Sale | $28.98 | 13,500 | 391,215 | 3,756,389 | Nov 25, 2015, 05:28 PM |
| Neff Thomas B | Chief Executive Officer | Nov 23, 2015 | Sale | $27.99 | 13,500 | 377,910 | 3,761,689 | Nov 25, 2015, 05:28 PM |
| KEARNS THOMAS F JR | Director | Nov 23, 2015 | Sale | $28.02 | 3,900 | 109,278 | 173,836 | Nov 25, 2015, 05:27 PM |
| KEARNS THOMAS F JR | Director | Nov 24, 2015 | Sale | $29.00 | 3,900 | 113,111 | 172,836 | Nov 25, 2015, 05:27 PM |
| Yu K Peony | VP, Clinical Development | Nov 17, 2015 | Sale | $28.00 | 5,000 | 140,000 | 183,345 | Nov 18, 2015, 08:22 PM |
| VALONE FRANK H MD | Chief Medical Officer | Nov 13, 2015 | Option Exercise | $2.90 | 10,000 | 29,000 | 94,044 | Nov 17, 2015, 07:31 PM |
| Yu K Peony | VP, Clinical Development | Nov 09, 2015 | Sale | $25.00 | 2,500 | 62,500 | 190,404 | Nov 10, 2015, 06:30 PM |
| Yu K Peony | VP, Clinical Development | Nov 10, 2015 | Sale | $26.23 | 2,500 | 65,575 | 187,904 | Nov 10, 2015, 06:30 PM |
| VALONE FRANK H MD | Chief Medical Officer | Nov 02, 2015 | Option Exercise | $2.90 | 10,000 | 29,000 | 94,044 | Nov 04, 2015, 06:24 PM |
| VALONE FRANK H MD | Chief Medical Officer | Nov 02, 2015 | Sale | $23.18 | 10,000 | 231,793 | 85,389 | Nov 04, 2015, 06:24 PM |
| Neff Thomas B | Chief Executive Officer | Oct 30, 2015 | Sale | $24.06 | 13,500 | 324,778 | 3,773,689 | Oct 30, 2015, 07:46 PM |
| Neff Thomas B | Chief Executive Officer | Oct 29, 2015 | Sale | $24.06 | 13,500 | 324,776 | 3,790,689 | Oct 30, 2015, 07:46 PM |
| KEARNS THOMAS F JR | Director | Oct 21, 2015 | Sale | $23.34 | 3,900 | 91,007 | 178,236 | Oct 22, 2015, 06:51 PM |
| KEARNS THOMAS F JR | Director | Oct 20, 2015 | Sale | $24.33 | 3,900 | 94,896 | 182,436 | Oct 22, 2015, 06:51 PM |
| VALONE FRANK H MD | Chief Medical Officer | Oct 19, 2015 | Option Exercise | $2.35 | 10,000 | 23,500 | 94,044 | Oct 21, 2015, 06:14 PM |
| VALONE FRANK H MD | Chief Medical Officer | Oct 19, 2015 | Sale | $23.00 | 10,000 | 230,000 | 84,044 | Oct 21, 2015, 06:14 PM |
| Yu K Peony | VP, Clinical Development | Oct 19, 2015 | Sale | $24.00 | 5,000 | 120,000 | 192,904 | Oct 21, 2015, 06:13 PM |
| Neff Thomas B | Chief Executive Officer | Oct 16, 2015 | Sale | $22.08 | 13,500 | 298,074 | 3,804,789 | Oct 16, 2015, 07:03 PM |
| Neff Thomas B | Chief Executive Officer | Oct 15, 2015 | Sale | $21.64 | 13,500 | 292,075 | 3,826,154 | Oct 16, 2015, 07:03 PM |
| Yu K Peony | VP, Clinical Development | Oct 15, 2015 | Sale | $20.50 | 2,500 | 51,250 | 200,404 | Oct 16, 2015, 07:02 PM |
| Yu K Peony | VP, Clinical Development | Oct 16, 2015 | Sale | $22.42 | 2,500 | 56,050 | 197,904 | Oct 16, 2015, 07:02 PM |
| Neff Thomas B | Chief Executive Officer | Oct 02, 2015 | Sale | $21.83 | 13,500 | 294,696 | 3,832,489 | Oct 02, 2015, 07:34 PM |
| Neff Thomas B | Chief Executive Officer | Oct 01, 2015 | Sale | $21.36 | 13,500 | 288,360 | 3,841,189 | Oct 02, 2015, 07:34 PM |
| VALONE FRANK H MD | Chief Medical Officer | Oct 01, 2015 | Option Exercise | $2.35 | 10,000 | 23,500 | 94,044 | Oct 02, 2015, 07:14 PM |
| VALONE FRANK H MD | Chief Medical Officer | Oct 01, 2015 | Sale | $21.38 | 10,000 | 213,782 | 84,044 | Oct 02, 2015, 07:14 PM |
| Neff Thomas B | Chief Executive Officer | Sep 17, 2015 | Option Exercise | $2.82 | 9,469 | 26,695 | 3,858,720 | Sep 18, 2015, 05:50 PM |
| Neff Thomas B | Chief Executive Officer | Sep 18, 2015 | Option Exercise | $2.90 | 9,469 | 27,460 | 3,854,689 | Sep 18, 2015, 05:50 PM |
| Neff Thomas B | Chief Executive Officer | Sep 17, 2015 | Sale | $29.04 | 13,500 | 391,996 | 3,856,051 | Sep 18, 2015, 05:50 PM |
| Neff Thomas B | Chief Executive Officer | Sep 18, 2015 | Sale | $29.16 | 13,500 | 393,695 | 3,856,720 | Sep 18, 2015, 05:50 PM |
| RIGGS RORY B | Director | Sep 14, 2015 | Sale | $27.56 | 25,571 | 704,737 | 480,200 | Sep 15, 2015, 08:41 PM |
| RIGGS RORY B | Director | Sep 11, 2015 | Sale | $27.67 | 24,429 | 675,927 | 510,200 | Sep 15, 2015, 08:41 PM |
| MADERO MIGUEL | Director | Sep 11, 2015 | Sale | $27.66 | 20,600 | 569,796 | 12,000 | Sep 15, 2015, 08:39 PM |
| Cotroneo Pat | VP, Finance and CFO | Sep 11, 2015 | Option Exercise | $2.90 | 1,340 | 3,886 | 108,591 | Sep 15, 2015, 08:38 PM |
| Cotroneo Pat | VP, Finance and CFO | Sep 15, 2015 | Sale | $27.95 | 1,093 | 30,549 | 107,498 | Sep 15, 2015, 08:38 PM |
| Yu K Peony | VP, Clinical Development | Sep 10, 2015 | Sale | $27.84 | 1,093 | 30,430 | 202,904 | Sep 14, 2015, 07:40 PM |
| Cotroneo Pat | VP, Finance and CFO | Sep 10, 2015 | Option Exercise | $2.35 | 5,000 | 11,750 | 112,251 | Sep 10, 2015, 07:03 PM |
| Cotroneo Pat | VP, Finance and CFO | Sep 08, 2015 | Option Exercise | $2.47 | 3,190 | 7,876 | 109,061 | Sep 10, 2015, 07:03 PM |
| Cotroneo Pat | VP, Finance and CFO | Sep 10, 2015 | Sale | $28.00 | 5,000 | 140,000 | 107,251 | Sep 10, 2015, 07:03 PM |
| Cotroneo Pat | VP, Finance and CFO | Sep 08, 2015 | Sale | $26.00 | 2,500 | 65,000 | 106,561 | Sep 10, 2015, 07:03 PM |
| Neff Thomas B | Chief Executive Officer | Sep 04, 2015 | Option Exercise | $2.35 | 9,469 | 22,252 | 3,862,751 | Sep 04, 2015, 07:58 PM |
| Neff Thomas B | Chief Executive Officer | Sep 04, 2015 | Sale | $22.88 | 13,500 | 308,884 | 3,853,282 | Sep 04, 2015, 07:58 PM |
| Yu K Peony | VP, Clinical Development | Sep 01, 2015 | Option Exercise | $22.84 | 657 | 15,006 | 203,997 | Sep 03, 2015, 08:58 PM |
| VALONE FRANK H MD | Chief Medical Officer | Sep 01, 2015 | Option Exercise | $22.84 | 704 | 16,079 | 84,044 | Sep 03, 2015, 08:56 PM |
| VALONE FRANK H MD | Chief Medical Officer | Sep 01, 2015 | Option Exercise | $2.35 | 10,000 | 23,500 | 94,748 | Sep 03, 2015, 08:56 PM |
| VALONE FRANK H MD | Chief Medical Officer | Sep 01, 2015 | Sale | $23.58 | 10,000 | 235,782 | 84,748 | Sep 03, 2015, 08:56 PM |
| Neff Thomas B | Chief Executive Officer | Sep 01, 2015 | Option Exercise | $22.84 | 2,282 | 52,121 | 3,870,813 | Sep 03, 2015, 08:52 PM |
| Neff Thomas B | Chief Executive Officer | Sep 03, 2015 | Option Exercise | $2.35 | 9,469 | 22,252 | 3,866,782 | Sep 03, 2015, 08:52 PM |
| Neff Thomas B | Chief Executive Officer | Sep 03, 2015 | Sale | $22.92 | 13,500 | 309,360 | 3,857,613 | Sep 03, 2015, 08:52 PM |
| Cotroneo Pat | VP, Finance and CFO | Sep 01, 2015 | Option Exercise | $22.84 | 657 | 15,006 | 106,561 | Sep 03, 2015, 08:51 PM |
| MADERO MIGUEL | Director | Aug 17, 2015 | Option Exercise | $4.03 | 12,000 | 48,300 | 32,600 | Aug 19, 2015, 06:06 PM |
| Neff Thomas B | Chief Executive Officer | Aug 06, 2015 | Option Exercise | $2.35 | 9,469 | 22,252 | 3,873,095 | Aug 07, 2015, 04:26 PM |
| Neff Thomas B | Chief Executive Officer | Aug 05, 2015 | Option Exercise | $2.35 | 9,469 | 22,252 | 3,877,126 | Aug 07, 2015, 04:26 PM |
| Neff Thomas B | Chief Executive Officer | Aug 05, 2015 | Sale | $23.82 | 13,500 | 321,561 | 3,867,657 | Aug 07, 2015, 04:26 PM |
| Neff Thomas B | Chief Executive Officer | Aug 06, 2015 | Sale | $22.82 | 13,500 | 308,075 | 3,867,826 | Aug 07, 2015, 04:26 PM |
| VALONE FRANK H MD | Chief Medical Officer | Aug 03, 2015 | Option Exercise | $2.35 | 10,000 | 23,500 | 94,748 | Aug 05, 2015, 11:57 AM |
| VALONE FRANK H MD | Chief Medical Officer | Aug 03, 2015 | Sale | $23.37 | 10,000 | 233,731 | 84,748 | Aug 05, 2015, 11:57 AM |
| Cotroneo Pat | VP, Finance and CFO | Jul 27, 2015 | Option Exercise | $2.90 | 1,400 | 4,060 | 107,218 | Jul 29, 2015, 06:12 PM |
| Neff Thomas B | Chief Executive Officer | Jul 22, 2015 | Option Exercise | $2.35 | 9,469 | 22,252 | 3,885,188 | Jul 24, 2015, 06:26 PM |
| Neff Thomas B | Chief Executive Officer | Jul 23, 2015 | Option Exercise | $2.35 | 9,469 | 22,252 | 3,881,157 | Jul 24, 2015, 06:26 PM |
| Neff Thomas B | Chief Executive Officer | Jul 22, 2015 | Sale | $24.62 | 13,500 | 332,370 | 3,875,719 | Jul 24, 2015, 06:26 PM |
| Neff Thomas B | Chief Executive Officer | Jul 23, 2015 | Sale | $24.80 | 13,500 | 334,800 | 3,871,688 | Jul 24, 2015, 06:26 PM |
| VALONE FRANK H MD | Chief Medical Officer | Jul 20, 2015 | Option Exercise | $2.35 | 1,000 | 2,350 | 85,748 | Jul 21, 2015, 08:29 PM |
| VALONE FRANK H MD | Chief Medical Officer | Jul 20, 2015 | Sale | $23.70 | 1,000 | 23,702 | 84,748 | Jul 21, 2015, 08:29 PM |
| Cotroneo Pat | VP, Finance and CFO | Jul 20, 2015 | Option Exercise | $2.35 | 2,500 | 5,875 | 108,318 | Jul 21, 2015, 06:14 PM |
| Cotroneo Pat | VP, Finance and CFO | Jul 20, 2015 | Sale | $24.00 | 2,500 | 60,000 | 105,818 | Jul 21, 2015, 06:14 PM |
| Cotroneo Pat | VP, Finance and CFO | Jul 17, 2015 | Sale | $23.23 | 5,381 | 125,001 | 105,818 | Jul 21, 2015, 06:14 PM |
| Neff Thomas B | Chief Executive Officer | Jul 09, 2015 | Option Exercise | $2.35 | 9,469 | 22,252 | 3,889,219 | Jul 10, 2015, 07:50 PM |
| Neff Thomas B | Chief Executive Officer | Jul 08, 2015 | Option Exercise | $2.35 | 9,469 | 22,252 | 3,893,250 | Jul 10, 2015, 07:50 PM |
| Neff Thomas B | Chief Executive Officer | Jul 09, 2015 | Sale | $22.13 | 13,500 | 298,755 | 3,879,750 | Jul 10, 2015, 07:50 PM |
| Neff Thomas B | Chief Executive Officer | Jul 08, 2015 | Sale | $22.08 | 13,500 | 298,080 | 3,883,781 | Jul 10, 2015, 07:50 PM |
| Yu K Peony | VP, Clinical Development | Jul 06, 2015 | Sale | $22.69 | 5,381 | 122,097 | 207,254 | Jul 07, 2015, 07:12 PM |
| Neff Thomas B | Chief Executive Officer | Jun 24, 2015 | Option Exercise | $2.35 | 9,469 | 22,252 | 3,901,312 | Jun 26, 2015, 07:21 PM |
| Neff Thomas B | Chief Executive Officer | Jun 25, 2015 | Option Exercise | $2.35 | 9,469 | 22,252 | 3,897,281 | Jun 26, 2015, 07:21 PM |
| Neff Thomas B | Chief Executive Officer | Jun 25, 2015 | Sale | $23.52 | 13,500 | 317,520 | 3,887,812 | Jun 26, 2015, 07:21 PM |
| Neff Thomas B | Chief Executive Officer | Jun 24, 2015 | Sale | $23.62 | 13,500 | 318,804 | 3,903,374 | Jun 26, 2015, 07:21 PM |
| Cotroneo Pat | VP, Finance and CFO | Jun 12, 2015 | Option Exercise | $2.90 | 12,000 | 34,800 | 111,199 | Jun 16, 2015, 05:34 PM |
| Neff Thomas B | Chief Executive Officer | Jun 01, 2015 | Option Exercise | $17.50 | 2,282 | 39,935 | 3,905,343 | Jun 02, 2015, 08:00 PM |
| Yu K Peony | VP, Clinical Development | Jun 01, 2015 | Option Exercise | $17.50 | 657 | 11,498 | 210,035 | Jun 02, 2015, 07:39 PM |
| VALONE FRANK H MD | Chief Medical Officer | Jun 01, 2015 | Option Exercise | $17.50 | 704 | 12,320 | 84,748 | Jun 02, 2015, 07:38 PM |
| Controneo Pat | VP, Finance and CFO | Jun 01, 2015 | Option Exercise | $17.50 | 657 | 11,498 | 99,199 | Jun 02, 2015, 07:35 PM |
| STERN JULIAN N | Director | May 20, 2015 | Option Exercise | $18.00 | 18,000 | 324,000 | 161,068 | May 22, 2015, 06:46 PM |
| Neff Thomas B | Chief Executive Officer | May 14, 2015 | Option Exercise | $21.39 | 9,337 | 199,718 | 3,907,625 | May 18, 2015, 08:33 PM |
| VALONE FRANK H MD | Chief Medical Officer | May 14, 2015 | Option Exercise | $21.39 | 2,906 | 62,159 | 85,452 | May 18, 2015, 08:31 PM |
| Yu K Peony | VP, Clinical Development | May 14, 2015 | Option Exercise | $21.39 | 2,712 | 58,010 | 202,692 | May 18, 2015, 08:30 PM |
| Yu K Peony | VP, Clinical Development | May 15, 2015 | Option Exercise | $3.20 | 8,000 | 25,600 | 210,692 | May 18, 2015, 08:30 PM |
| Controneo Pat | VP, Finance and CFO | May 14, 2015 | Option Exercise | $21.39 | 2,712 | 58,010 | 99,856 | May 18, 2015, 08:28 PM |
Load More Insider Transactions
Buy
Sale
Option Exercise
| Owner | Relationship | Date | Value($) |
| Wettig Thane | CEO | 05/01/2024 | 24,383 |
| Wettig Thane | CEO | 03/22/2024 | 2,018 |
| Wettig Thane | CEO | 03/07/2024 | 95,470 |
| Graham Juan | CHIEF FINANCIAL OFFICER | 03/07/2024 | 2,114 |
| Graham Juan | CHIEF FINANCIAL OFFICER | 03/06/2024 | 38,801 |
| Wettig Thane | CEO | 03/06/2024 | 8,480 |
| Chung Christine | SVP, CHINA OPERATIONS | 03/06/2024 | 44,113 |
| Wettig Thane | CEO | 02/01/2024 | 55,671 |
| Wettig Thane | CEO | 12/22/2023 | 622 |
| Graham Juan | Chief Financial Officer | 12/06/2023 | 9,032 |
| Graham Juan | Chief Financial Officer | 12/07/2023 | 668 |
| Chung Christine | SVP, China Operations | 12/06/2023 | 10,546 |
| Wettig Thane | CEO | 12/06/2023 | 974 |
| Wettig Thane | CEO | 11/01/2023 | 11,949 |
| Wettig Thane | Interim CEO | 09/22/2023 | 644 |
| Graham Juan | Chief Financial Officer | 09/07/2023 | 1,088 |
| Graham Juan | Chief Financial Officer | 09/06/2023 | 685 |
| Wettig Thane | Interim CEO | 09/06/2023 | 1,618 |
| Eisner Mark | EVP, Chief Medical Officer | 09/06/2023 | 1,791 |
| Chung Christine | SVP, China Operations | 09/06/2023 | 3,186 |
| Eisner Mark | EVP, Chief Medical Officer | 09/01/2023 | 1,150 |
| Henderson Jeffrey William | Director | 09/01/2023 | 2,060 |
| Henderson Jeffrey William | Director | 08/04/2023 | 3,820 |
| Henderson Jeffrey William | Director | 07/11/2023 | 5,380 |
| Conterno Enrique A | Chief Executive Officer | 07/07/2023 | 5,264 |
| Wettig Thane | Chief Commercial Officer | 06/23/2023 | 13,075 |
| Wettig Thane | Chief Commercial Officer | 06/07/2023 | 29,951 |
| Chung Christine | SVP, China Operations | 06/14/2023 | 104,925 |
| Chung Christine | SVP, China Operations | 06/13/2023 | 110,000 |
| Cravatt Benjamin | Director | 06/09/2023 | 67,717 |
| Brennan Aoife | Director | 06/09/2023 | 81,367 |
| Blaug Suzanne | Director | 06/09/2023 | 146,571 |
| Ho Maykin | Director | 06/08/2023 | 148,591 |
| EDWARDS JEFFREY L | Director | 06/09/2023 | 135,622 |
| Henderson Jeffrey William | Director | 06/08/2023 | 122,185 |
| Schoeneck James A | Director | 06/07/2023 | 127,987 |
| Wettig Thane | Chief Commercial Officer | 06/07/2023 | 29,951 |
| Graham Juan | Chief Financial Officer | 06/07/2023 | 30,320 |
| Chung Christine | SVP, China Operations | 06/07/2023 | 61,894 |
| Eisner Mark | EVP, Chief Medical Officer | 06/07/2023 | 34,792 |
| Conterno Enrique A | Chief Executive Officer | 06/07/2023 | 151,583 |
| Eisner Mark | EVP, Chief Medical Officer | 06/02/2023 | 20,525 |
| Conterno Enrique A | Chief Executive Officer | 04/10/2023 | 36,483 |
| Eisner Mark | Chief Medical Officer | 04/04/2023 | 172,473 |
| Chung Christine | SVP, China Operations | 04/04/2023 | 123,785 |
| Wettig Thane | Chief Commercial Officer | 03/23/2023 | 16,933 |
| Conterno Enrique A | Chief Executive Officer | 03/10/2023 | 393,625 |
| Chung Christine | SVP, China Operations | 03/08/2023 | 176,736 |
| Chung Christine | SVP, China Operations | 03/10/2023 | 153,621 |
| Conterno Enrique A | Chief Executive Officer | 03/10/2023 | 638,013 |
| Conterno Enrique A | Chief Executive Officer | 03/08/2023 | 521,958 |
| Eisner Mark | Chief Medical Officer | 03/10/2023 | 204,801 |
| Eisner Mark | Chief Medical Officer | 03/08/2023 | 155,771 |
| Graham Juan | Chief Financial Officer | 03/10/2023 | 99,209 |
| Graham Juan | Chief Financial Officer | 03/08/2023 | 58,158 |
| Wettig Thane | Chief Commercial Officer | 03/10/2023 | 154,893 |
| Wettig Thane | Chief Commercial Officer | 03/08/2023 | 132,542 |
| Eisner Mark | Chief Medical Officer | 03/02/2023 | 25,960 |
| Conterno Enrique A | Chief Executive Officer | 01/06/2023 | 30,683 |
| Chung Christine | SVP, China Operations | 12/08/2022 | 40,975 |
| Chung Christine | SVP, China Operations | 09/06/2022 | 22,693 |
| Wettig Thane | Chief Commercial Officer | 12/23/2022 | 11,597 |
| Graham Juan | Chief Financial Officer | 12/12/2022 | 20,402 |
| Graham Juan | Chief Financial Officer | 12/09/2022 | 11,629 |
| Graham Juan | Chief Financial Officer | 12/08/2022 | 85,498 |
| Graham Juan | Chief Financial Officer | 12/12/2022 | 20,402 |
| Graham Juan | Chief Financial Officer | 12/09/2022 | 11,637 |
| Chung Christine | SVP, China Operations | 12/08/2022 | 17,306 |
| Wettig Thane | Chief Commercial Officer | 12/08/2022 | 6,032 |
| Conterno Enrique A | Chief Executive Officer | 12/08/2022 | 40,154 |
| Eisner Mark | Chief Medical Officer | 12/01/2022 | 16,303 |
| Conterno Enrique A | Chief Executive Officer | 10/06/2022 | 18,481 |
| Chung Christine | SVP, China Operations | 09/30/2022 | 60,926 |
| Eisner Mark | Chief Medical Officer | 09/30/2022 | 88,169 |
| Wettig Thane | Chief Commercial Officer | 09/22/2022 | 8,030 |
| Graham Juan | Chief Financial Officer | 09/07/2022 | 37,974 |
| Chung Christine | SVP, China Operations | 09/06/2022 | 6,351 |
| Wettig Thane | Chief Commercial Officer | 09/06/2022 | 4,414 |
| Conterno Enrique A | Chief Executive Officer | 09/06/2022 | 21,725 |
| Eisner Mark | Chief Medical Officer | 09/01/2022 | 9,896 |
| Conterno Enrique A | Chief Executive Officer | 07/06/2022 | 16,070 |
| Wettig Thane | Chief Commercial Officer | 06/22/2022 | 7,480 |
| Chung Christine | SVP, China Operations | 06/06/2022 | 17,575 |
| Conterno Enrique A | Chief Executive Officer | 06/06/2022 | 16,834 |
| Wettig Thane | Chief Commercial Officer | 06/06/2022 | 3,420 |
| Conterno Enrique A | Chief Executive Officer | 04/07/2022 | 16,689 |
| Chung Christine | SVP, China Operations | 03/31/2022 | 56,278 |
| Eisner Mark | Chief Medical Officer | 03/31/2022 | 77,433 |
| Wettig Thane | Chief Commercial Officer | 03/22/2022 | 8,718 |
| Wettig Thane | Chief Commercial Officer | 03/07/2022 | 21,649 |
| Chung Christine | SVP, China Operations | 03/07/2022 | 49,554 |
| Conterno Enrique A | Chief Executive Officer | 03/07/2022 | 89,858 |
| Eisner Mark | Chief Medical Officer | 03/01/2022 | 10,297 |
| Conterno Enrique A | Chief Executive Officer | 01/06/2022 | 21,396 |
| Eisner Mark | Chief Medical Officer | 01/03/2022 | 104,377 |
| Chung Christine | SVP, China Operations | 01/03/2022 | 78,309 |
| Wettig Thane | Chief Commercial Officer | 12/22/2021 | 7,739 |
| Chung Christine | SVP, China Operations | 12/06/2021 | 37,859 |
| Eisner Mark | Chief Medical Officer | 12/01/2021 | 54,876 |
| Conterno Enrique A | Chief Executive Officer | 10/06/2021 | 18,962 |
| Wettig Thane | Chief Commercial Officer | 09/22/2021 | 6,312 |
| KEARNS THOMAS F JR | Director | 09/15/2021 | 151,707 |
| Cotroneo Pat | Executive Advisor & Former CFO | 09/07/2021 | 26,570 |
| Chung Christine | SVP, China Operations | 09/07/2021 | 25,192 |
| Wettig Thane | Chief Commercial Officer | 08/26/2021 | 35,743 |
| Conterno Enrique A | Chief Executive Officer | 07/06/2021 | 46,587 |
| Chung Christine | SVP, China Operations | 06/07/2021 | 46,487 |
| KEARNS THOMAS F JR | Director | 03/11/2021 | 63,000 |
| KEARNS THOMAS F JR | Director | 03/11/2021 | 630,360 |
| Kouchakji Elias | SVP, Clinical Dev, Drug Safety | 03/08/2021 | 174,225 |
| Cotroneo Pat | SVP, Finance and CFO | 03/08/2021 | 188,774 |
| Chung Christine | SVP, China Operations | 03/08/2021 | 189,508 |
| Kurkijarvi Kalevi | Director | 02/17/2021 | 171,900 |
| Kurkijarvi Kalevi | Director | 02/17/2021 | 314,383 |
| Kurkijarvi Kalevi | Director | 01/19/2021 | 114,300 |
| Kurkijarvi Kalevi | Director | 01/19/2021 | 260,280 |
| Kurkijarvi Kalevi | Director | 01/14/2021 | 114,281 |
| Kurkijarvi Kalevi | Director | 01/14/2021 | 240,200 |
| Conterno Enrique A | Chief Executive Officer | 01/06/2021 | 207,295 |
| Schoeneck James A | Director | 01/04/2021 | 58,650 |
| Kurkijarvi Kalevi | Director | 12/28/2020 | 110,059 |
| Kurkijarvi Kalevi | Director | 12/28/2020 | 242,455 |
| Yu K Peony | Chief Medical Officer | 12/16/2020 | 139,394 |
| Cotroneo Pat | SVP, Finance and CFO | 12/15/2020 | 133,765 |
| Yu K Peony | Chief Medical Officer | 12/07/2020 | 138,231 |
| Kouchakji Elias | SVP, Clinical Dev, Drug Safety | 12/07/2020 | 114,549 |
| Cotroneo Pat | SVP, Finance and CFO | 12/07/2020 | 126,558 |
| Chung Christine | SVP, China Operations | 12/07/2020 | 127,608 |
| Kouchakji Elias | SVP, Clinical Dev, Drug Safety | 11/17/2020 | 103,220 |
| Yu K Peony | Chief Medical Officer | 09/16/2020 | 147,478 |
| Cotroneo Pat | SVP, Finance and CFO | 09/15/2020 | 133,944 |
| Yu K Peony | Chief Medical Officer | 09/08/2020 | 138,749 |
| Kouchakji Elias | SVP, Clinical Dev, Drug Safety | 09/08/2020 | 115,012 |
| Cotroneo Pat | SVP, Finance and CFO | 09/08/2020 | 127,070 |
| Chung Christine | SVP, China Operations | 09/08/2020 | 128,082 |
| Yu K Peony | Chief Medical Officer | 09/03/2020 | 180,000 |
| Yu K Peony | Chief Medical Officer | 09/03/2020 | 508,900 |
| Cotroneo Pat | SVP, Finance and CFO | 09/03/2020 | 349,582 |
| Cotroneo Pat | SVP, Finance and CFO | 09/03/2020 | 763,854 |
| Schoeneck James A | Director | 08/20/2020 | 35,700 |
| Cotroneo Pat | SVP, Finance and CFO | 08/11/2020 | 135,712 |
| Cotroneo Pat | SVP, Finance and CFO | 08/07/2020 | 437,322 |
| Cotroneo Pat | SVP, Finance and CFO | 08/07/2020 | 1,082,592 |
| Yu K Peony | Chief Medical Officer | 07/24/2020 | 141,915 |
| Cotroneo Pat | SVP, Finance and CFO | 06/16/2020 | 155,863 |
| Conterno Enrique A | Chief Executive Officer | 06/10/2020 | 290,282 |
| Conterno Enrique A | Chief Executive Officer | 06/11/2020 | 698,599 |
| Rosenkranz Roberto Pedro | Director | 06/09/2020 | 572,400 |
| Chung Christine | SVP, China Operations | 06/08/2020 | 102,107 |
| Cotroneo Pat | SVP, Finance and CFO | 06/08/2020 | 72,463 |
| Yu K Peony | Chief Medical Officer | 06/08/2020 | 110,644 |
| Kouchakji Elias | SVP, Clinical Dev, Drug Safety | 06/08/2020 | 91,688 |
| KEARNS THOMAS F JR | Director | 03/19/2020 | 52,200 |
| KEARNS THOMAS F JR | Director | 03/19/2020 | 417,074 |
| Chung Christine | SVP, China Operations | 03/06/2020 | 402,103 |
| Chung Christine | SVP, China Operations | 03/19/2020 | 186,563 |
| Chung Christine | SVP, China Operations | 03/18/2020 | 10,160 |
| Chung Christine | SVP, China Operations | 03/19/2020 | 190,282 |
| Chung Christine | SVP, China Operations | 03/18/2020 | 96,799 |
| Yu K Peony | Chief Medical Officer | 03/06/2020 | 390,190 |
| Yu K Peony | Chief Medical Officer | 03/16/2020 | 72,712 |
| Kouchakji Elias | SVP, Clinical Dev, Drug Safety | 03/06/2020 | 259,108 |
| Cotroneo Pat | SVP, Finance and CFO | 03/06/2020 | 193,825 |
| Cotroneo Pat | SVP, Finance and CFO | 03/16/2020 | 243,540 |
| Chung Christine | SVP, China Operations | 02/12/2020 | 142,875 |
| Chung Christine | SVP, China Operations | 02/11/2020 | 142,875 |
| Chung Christine | SVP, China Operations | 02/11/2020 | 250,200 |
| Chung Christine | SVP, China Operations | 02/12/2020 | 258,616 |
| Kurkijarvi Kalevi | Director | 02/10/2020 | 110,040 |
| Kurkijarvi Kalevi | Director | 02/10/2020 | 256,140 |
| Schoeneck James A | Interim President | 01/06/2020 | 473,729 |
| Kurkijarvi Kalevi | Director | 01/06/2020 | 108,000 |
| Kurkijarvi Kalevi | Director | 01/06/2020 | 255,960 |
| Chung Christine | SVP, China Operations | 01/07/2020 | 142,875 |
| Chung Christine | SVP, China Operations | 01/06/2020 | 142,875 |
| Chung Christine | SVP, China Operations | 01/07/2020 | 240,525 |
| Chung Christine | SVP, China Operations | 01/06/2020 | 241,762 |
| Cotroneo Pat | SVP, Finance and CFO | 12/20/2019 | 439,427 |
| Cotroneo Pat | SVP, Finance and CFO | 12/20/2019 | 2,715,517 |
| Chung Christine | SVP, China Operations | 12/17/2019 | 142,875 |
| Chung Christine | SVP, China Operations | 12/16/2019 | 53,848 |
| Chung Christine | SVP, China Operations | 12/17/2019 | 264,244 |
| Chung Christine | SVP, China Operations | 12/16/2019 | 264,832 |
| Yu K Peony | Chief Medical Officer | 12/16/2019 | 159,646 |
| Kurkijarvi Kalevi | Director | 12/09/2019 | 108,000 |
| Kurkijarvi Kalevi | Director | 12/09/2019 | 285,000 |
| Kouchakji Elias | SVP, Clinical Dev, Drug Safety | 12/06/2019 | 115,726 |
| Cotroneo Pat | SVP, Finance and CFO | 12/06/2019 | 148,994 |
| Chung Christine | SVP, China Operations | 12/06/2019 | 164,870 |
| Yu K Peony | Chief Medical Officer | 12/06/2019 | 159,230 |
| Yu K Peony | Chief Medical Officer | 12/04/2019 | 72,576 |
| Chung Christine | SVP, China Operations | 11/14/2019 | 122,838 |
| Chung Christine | SVP, China Operations | 11/13/2019 | 109,069 |
| Chung Christine | SVP, China Operations | 11/13/2019 | 194,288 |
| Chung Christine | SVP, China Operations | 11/14/2019 | 195,440 |
| Cotroneo Pat | SVP, Finance and CFO | 11/08/2019 | 36,250 |
| Kurkijarvi Kalevi | Director | 11/07/2019 | 58,650 |
| Kurkijarvi Kalevi | Director | 11/07/2019 | 229,624 |
| Chung Christine | SVP, China Operations | 10/09/2019 | 109,069 |
| Chung Christine | SVP, China Operations | 10/08/2019 | 109,069 |
| Chung Christine | SVP, China Operations | 10/09/2019 | 205,763 |
| Chung Christine | SVP, China Operations | 10/08/2019 | 206,914 |
| Kurkijarvi Kalevi | Director | 10/07/2019 | 58,650 |
| Kurkijarvi Kalevi | Director | 10/07/2019 | 220,380 |
| Chung Christine | SVP, China Operations | 09/20/2019 | 109,069 |
| Chung Christine | SVP, China Operations | 09/19/2019 | 41,107 |
| Chung Christine | SVP, China Operations | 09/20/2019 | 224,269 |
| Chung Christine | SVP, China Operations | 09/19/2019 | 227,550 |
| Yu K Peony | Chief Medical Officer | 09/16/2019 | 139,905 |
| Cotroneo Pat | SVP, Finance and CFO | 09/17/2019 | 132,457 |
| Yu K Peony | Chief Medical Officer | 09/06/2019 | 346,653 |
| Kouchakji Elias | SVP, Clinical Dev, Drug Safety | 09/06/2019 | 230,949 |
| Kurkijarvi Kalevi | Director | 09/09/2019 | 35,700 |
| Kurkijarvi Kalevi | Director | 09/09/2019 | 245,723 |
| Cotroneo Pat | SVP, Finance and CFO | 09/06/2019 | 131,042 |
| Chung Christine | SVP, China Operations | 09/06/2019 | 351,654 |
| Chung Christine | SVP, China Operations | 08/23/2019 | 109,069 |
| Chung Christine | SVP, China Operations | 08/22/2019 | 109,069 |
| Chung Christine | SVP, China Operations | 08/22/2019 | 246,583 |
| Chung Christine | SVP, China Operations | 08/23/2019 | 239,099 |
| Neff Thomas B | Chief Executive Officer | 08/21/2019 | 19,819 |
| Neff Thomas B | Chief Executive Officer | 08/22/2019 | 19,819 |
| Neff Thomas B | Chief Executive Officer | 08/21/2019 | 824,136 |
| Neff Thomas B | Chief Executive Officer | 08/22/2019 | 62,066 |
| Neff Thomas B | Chief Executive Officer | 08/22/2019 | 807,129 |
| Neff Thomas B | Chief Executive Officer | 08/21/2019 | 63,541 |
| Neff Thomas B | Chief Executive Officer | 08/12/2019 | 19,819 |
| Neff Thomas B | Chief Executive Officer | 08/13/2019 | 19,819 |
| Neff Thomas B | Chief Executive Officer | 08/12/2019 | 832,329 |
| Neff Thomas B | Chief Executive Officer | 08/13/2019 | 64,680 |
| Neff Thomas B | Chief Executive Officer | 08/13/2019 | 840,006 |
| Neff Thomas B | Chief Executive Officer | 08/12/2019 | 64,056 |
| Kurkijarvi Kalevi | Director | 08/05/2019 | 21,000 |
| Kurkijarvi Kalevi | Director | 08/05/2019 | 271,320 |
| Neff Thomas B | Chief Executive Officer | 07/25/2019 | 19,819 |
| Neff Thomas B | Chief Executive Officer | 07/24/2019 | 19,819 |
| Neff Thomas B | Chief Executive Officer | 07/24/2019 | 66,036 |
| Neff Thomas B | Chief Executive Officer | 07/24/2019 | 856,336 |
| Neff Thomas B | Chief Executive Officer | 07/25/2019 | 66,472 |
| Neff Thomas B | Chief Executive Officer | 07/25/2019 | 863,858 |
| Neff Thomas B | Chief Executive Officer | 07/10/2019 | 19,819 |
| Neff Thomas B | Chief Executive Officer | 07/11/2019 | 19,819 |
| Neff Thomas B | Chief Executive Officer | 07/10/2019 | 63,541 |
| Neff Thomas B | Chief Executive Officer | 07/10/2019 | 824,300 |
| Neff Thomas B | Chief Executive Officer | 07/11/2019 | 63,938 |
| Neff Thomas B | Chief Executive Officer | 07/11/2019 | 830,836 |
| Chung Christine | SVP, China Operations | 07/11/2019 | 158,663 |
| Chung Christine | SVP, China Operations | 07/10/2019 | 166,837 |
| Chung Christine | SVP, China Operations | 07/11/2019 | 253,915 |
| Chung Christine | SVP, China Operations | 07/10/2019 | 251,953 |
| Kurkijarvi Kalevi | Director | 07/08/2019 | 21,000 |
| Kurkijarvi Kalevi | Director | 07/08/2019 | 255,570 |
| Kouchakji Elias | SVP, Clinical Dev, Drug Safety | 06/28/2019 | 129,285 |
| Neff Thomas B | Chief Executive Officer | 06/19/2019 | 19,819 |
| Neff Thomas B | Chief Executive Officer | 06/20/2019 | 19,819 |
| Neff Thomas B | Chief Executive Officer | 06/19/2019 | 62,378 |
| Neff Thomas B | Chief Executive Officer | 06/19/2019 | 809,968 |
| Neff Thomas B | Chief Executive Officer | 06/20/2019 | 62,840 |
| Neff Thomas B | Chief Executive Officer | 06/20/2019 | 816,820 |
| Kouchakji Elias | SVP, Clinical Dev, Drug Safety | 06/18/2019 | 233,200 |
| Cotroneo Pat | SVP, Finance and CFO | 06/18/2019 | 138,027 |
| Chung Christine | SVP, China Operations | 06/18/2019 | 62,879 |
| Chung Christine | SVP, China Operations | 06/19/2019 | 166,837 |
| Chung Christine | SVP, China Operations | 06/18/2019 | 247,950 |
| Chung Christine | SVP, China Operations | 06/19/2019 | 247,613 |
| Yu K Peony | Chief Medical Officer | 06/12/2019 | 155,923 |
| Yu K Peony | Chief Medical Officer | 06/14/2019 | 140,083 |
| Yu K Peony | Chief Medical Officer | 06/06/2019 | 128,722 |
| Neff Thomas B | Chief Executive Officer | 06/06/2019 | 327,244 |
| Neff Thomas B | Chief Executive Officer | 06/06/2019 | 19,819 |
| Neff Thomas B | Chief Executive Officer | 06/05/2019 | 19,819 |
| Neff Thomas B | Chief Executive Officer | 06/06/2019 | 698,073 |
| Neff Thomas B | Chief Executive Officer | 06/05/2019 | 54,621 |
| Neff Thomas B | Chief Executive Officer | 06/05/2019 | 707,934 |
| Neff Thomas B | Chief Executive Officer | 06/06/2019 | 53,824 |
| Kouchakji Elias | SVP, Clinical Dev, Drug Safety | 06/06/2019 | 78,842 |
| Cotroneo Pat | SVP, Finance and CFO | 06/06/2019 | 120,447 |
| Chung Christine | SVP, China Operations | 06/06/2019 | 133,319 |
| Kurkijarvi Kalevi | Director | 06/06/2019 | 17,400 |
| Kurkijarvi Kalevi | Director | 06/06/2019 | 227,145 |
| Schoeneck James A | Director | 05/28/2019 | 47,800 |
| Neff Thomas B | Chief Executive Officer | 05/23/2019 | 19,819 |
| Neff Thomas B | Chief Executive Officer | 05/22/2019 | 19,819 |
| Neff Thomas B | Chief Executive Officer | 05/23/2019 | 644,275 |
| Neff Thomas B | Chief Executive Officer | 05/22/2019 | 50,637 |
| Neff Thomas B | Chief Executive Officer | 05/22/2019 | 657,432 |
| Neff Thomas B | Chief Executive Officer | 05/23/2019 | 49,701 |
| Rosenkranz Roberto Pedro | Director | 05/15/2019 | 494,730 |
| Neff Thomas B | Chief Executive Officer | 05/14/2019 | 19,819 |
| Neff Thomas B | Chief Executive Officer | 05/13/2019 | 19,819 |
| Neff Thomas B | Chief Executive Officer | 05/14/2019 | 52,331 |
| Neff Thomas B | Chief Executive Officer | 05/14/2019 | 678,436 |
| Neff Thomas B | Chief Executive Officer | 05/13/2019 | 50,712 |
| Neff Thomas B | Chief Executive Officer | 05/13/2019 | 659,075 |
| Kurkijarvi Kalevi | Director | 05/08/2019 | 17,400 |
| Kurkijarvi Kalevi | Director | 05/08/2019 | 275,622 |
| Chung Christine | SVP, China Operations | 05/08/2019 | 166,837 |
| Chung Christine | SVP, China Operations | 05/07/2019 | 166,837 |
| Chung Christine | SVP, China Operations | 05/08/2019 | 260,505 |
| Chung Christine | SVP, China Operations | 05/07/2019 | 261,565 |
| Schoeneck James A | Director | 05/07/2019 | 5,800 |
| Schoeneck James A | Director | 05/07/2019 | 94,045 |
| Cotroneo Pat | SVP, Finance and CFO | 05/06/2019 | 20,300 |
| Neff Thomas B | Chief Executive Officer | 04/17/2019 | 19,819 |
| Neff Thomas B | Chief Executive Officer | 04/18/2019 | 19,819 |
| Neff Thomas B | Chief Executive Officer | 04/18/2019 | 66,470 |
| Neff Thomas B | Chief Executive Officer | 04/18/2019 | 861,263 |
| Neff Thomas B | Chief Executive Officer | 04/17/2019 | 66,128 |
| Neff Thomas B | Chief Executive Officer | 04/17/2019 | 859,629 |
| Kurkijarvi Kalevi | Director | 04/15/2019 | 11,600 |
| Kurkijarvi Kalevi | Director | 04/15/2019 | 192,360 |
| Cotroneo Pat | SVP, Finance and CFO | 04/15/2019 | 29,000 |
| Schoeneck James A | Director | 04/08/2019 | 5,800 |
| Schoeneck James A | Director | 04/08/2019 | 105,800 |
| Kurkijarvi Kalevi | Director | 04/08/2019 | 11,600 |
| Kurkijarvi Kalevi | Director | 04/08/2019 | 212,121 |
| Neff Thomas B | Chief Executive Officer | 04/03/2019 | 19,819 |
| Neff Thomas B | Chief Executive Officer | 04/04/2019 | 19,819 |
| Neff Thomas B | Chief Executive Officer | 04/04/2019 | 75,695 |
| Neff Thomas B | Chief Executive Officer | 04/04/2019 | 984,763 |
| Neff Thomas B | Chief Executive Officer | 04/03/2019 | 77,423 |
| Neff Thomas B | Chief Executive Officer | 04/03/2019 | 1,005,314 |
| Routti Jorma | Director | 03/26/2019 | 682,440 |
| Neff Thomas B | Chief Executive Officer | 03/20/2019 | 19,819 |
| Neff Thomas B | Chief Executive Officer | 03/21/2019 | 19,819 |
| Neff Thomas B | Chief Executive Officer | 03/21/2019 | 79,167 |
| Neff Thomas B | Chief Executive Officer | 03/21/2019 | 1,023,012 |
| Neff Thomas B | Chief Executive Officer | 03/20/2019 | 78,850 |
| Neff Thomas B | Chief Executive Officer | 03/20/2019 | 1,019,590 |
| Cotroneo Pat | SVP, Finance and CFO | 03/19/2019 | 424,718 |
| Yu K Peony | Chief Medical Officer | 03/14/2019 | 514,863 |
| Schoeneck James A | Director | 03/07/2019 | 5,800 |
| Schoeneck James A | Director | 03/07/2019 | 109,472 |
| Neff Thomas B | Chief Executive Officer | 03/07/2019 | 19,819 |
| Neff Thomas B | Chief Executive Officer | 03/06/2019 | 19,819 |
| Neff Thomas B | Chief Executive Officer | 03/07/2019 | 1,010,844 |
| Neff Thomas B | Chief Executive Officer | 03/06/2019 | 79,769 |
| Neff Thomas B | Chief Executive Officer | 03/06/2019 | 1,037,316 |
| Neff Thomas B | Chief Executive Officer | 03/07/2019 | 77,890 |
| Yu K Peony | Chief Medical Officer | 03/04/2019 | 40,672 |
| Yu K Peony | Chief Medical Officer | 03/06/2019 | 274,843 |
| Neff Thomas B | Chief Executive Officer | 03/06/2019 | 836,423 |
| Neff Thomas B | Chief Executive Officer | 03/04/2019 | 134,283 |
| Cotroneo Pat | SVP, Finance and CFO | 03/06/2019 | 291,350 |
| Cotroneo Pat | SVP, Finance and CFO | 03/04/2019 | 40,672 |
| Cotroneo Pat | SVP, Finance and CFO | 02/28/2019 | 438,582 |
| Cotroneo Pat | SVP, Finance and CFO | 02/28/2019 | 888,391 |
| Neff Thomas B | Chief Executive Officer | 02/20/2019 | 37,148 |
| Neff Thomas B | Chief Executive Officer | 02/19/2019 | 37,148 |
| Neff Thomas B | Chief Executive Officer | 02/20/2019 | 52,377 |
| Neff Thomas B | Chief Executive Officer | 02/20/2019 | 1,079,305 |
| Neff Thomas B | Chief Executive Officer | 02/19/2019 | 52,941 |
| Neff Thomas B | Chief Executive Officer | 02/19/2019 | 1,090,797 |
| Schoeneck James A | Director | 02/07/2019 | 5,800 |
| Schoeneck James A | Director | 02/07/2019 | 114,340 |
| Neff Thomas B | Chief Executive Officer | 02/08/2019 | 37,148 |
| Neff Thomas B | Chief Executive Officer | 02/07/2019 | 37,148 |
| Neff Thomas B | Chief Executive Officer | 02/08/2019 | 52,222 |
| Neff Thomas B | Chief Executive Officer | 02/08/2019 | 1,075,595 |
| Neff Thomas B | Chief Executive Officer | 02/07/2019 | 1,592,860 |
| Neff Thomas B | Chief Executive Officer | 01/23/2019 | 37,148 |
| Neff Thomas B | Chief Executive Officer | 01/22/2019 | 37,148 |
| Neff Thomas B | Chief Executive Officer | 01/23/2019 | 73,100 |
| Neff Thomas B | Chief Executive Officer | 01/23/2019 | 36,385 |
| Neff Thomas B | Chief Executive Officer | 01/23/2019 | 1,451,018 |
| Neff Thomas B | Chief Executive Officer | 01/22/2019 | 1,559,640 |
| Schoeneck James A | Director | 01/07/2019 | 5,800 |
| Schoeneck James A | Director | 01/07/2019 | 91,800 |
| Neff Thomas B | Chief Executive Officer | 01/04/2019 | 75,283 |
| Neff Thomas B | Chief Executive Officer | 01/03/2019 | 108,000 |
| Neff Thomas B | Chief Executive Officer | 01/04/2019 | 1,347,408 |
| Neff Thomas B | Chief Executive Officer | 01/03/2019 | 1,316,072 |
| Rosenkranz Roberto Pedro | Director | 12/20/2018 | 9,775 |
| Rosenkranz Roberto Pedro | Director | 12/20/2018 | 41,000 |
| Kurkijarvi Kalevi | Director | 12/19/2018 | 11,600 |
| Kurkijarvi Kalevi | Director | 12/19/2018 | 165,288 |
| Cotroneo Pat | SVP, Finance and CFO | 12/18/2018 | 136,863 |
| Yu K Peony | Chief Medical Officer | 12/14/2018 | 132,021 |
| Neff Thomas B | Chief Executive Officer | 12/06/2018 | 260,847 |
| Neff Thomas B | Chief Executive Officer | 12/03/2018 | 100,468 |
| Neff Thomas B | Chief Executive Officer | 12/06/2018 | 39,607 |
| Neff Thomas B | Chief Executive Officer | 12/06/2018 | 75,111 |
| Neff Thomas B | Chief Executive Officer | 12/06/2018 | 1,152,666 |
| Yu K Peony | Chief Medical Officer | 12/06/2018 | 96,963 |
| Yu K Peony | Chief Medical Officer | 12/03/2018 | 43,622 |
| Cotroneo Pat | SVP, Finance and CFO | 12/03/2018 | 43,622 |
| Cotroneo Pat | SVP, Finance and CFO | 12/06/2018 | 93,198 |
| Neff Thomas B | Chief Executive Officer | 11/20/2018 | 37,148 |
| Neff Thomas B | Chief Executive Officer | 11/21/2018 | 37,148 |
| Neff Thomas B | Chief Executive Officer | 11/21/2018 | 36,233 |
| Neff Thomas B | Chief Executive Officer | 11/21/2018 | 745,983 |
| Neff Thomas B | Chief Executive Officer | 11/20/2018 | 36,031 |
| Neff Thomas B | Chief Executive Officer | 11/20/2018 | 742,041 |
| Rosenkranz Roberto Pedro | Director | 11/15/2018 | 9,775 |
| Rosenkranz Roberto Pedro | Director | 11/15/2018 | 39,240 |
| Kurkijarvi Kalevi | Director | 11/15/2018 | 11,600 |
| Kurkijarvi Kalevi | Director | 11/15/2018 | 159,094 |
| Neff Thomas B | Chief Executive Officer | 11/02/2018 | 37,148 |
| Neff Thomas B | Chief Executive Officer | 11/01/2018 | 37,148 |
| Neff Thomas B | Chief Executive Officer | 11/01/2018 | 40,465 |
| Neff Thomas B | Chief Executive Officer | 11/01/2018 | 832,338 |
| Neff Thomas B | Chief Executive Officer | 11/02/2018 | 40,952 |
| Neff Thomas B | Chief Executive Officer | 11/02/2018 | 842,866 |
| Schoeneck James A | Director | 10/30/2018 | 333,300 |
| Rosenkranz Roberto Pedro | Director | 10/18/2018 | 9,775 |
| Rosenkranz Roberto Pedro | Director | 10/18/2018 | 55,387 |
| Kurkijarvi Kalevi | Director | 10/18/2018 | 11,600 |
| Kurkijarvi Kalevi | Director | 10/18/2018 | 221,670 |
| Neff Thomas B | Chief Executive Officer | 10/19/2018 | 37,148 |
| Neff Thomas B | Chief Executive Officer | 10/18/2018 | 37,148 |
| Neff Thomas B | Chief Executive Officer | 10/19/2018 | 49,285 |
| Neff Thomas B | Chief Executive Officer | 10/19/2018 | 1,019,110 |
| Neff Thomas B | Chief Executive Officer | 10/18/2018 | 50,088 |
| Neff Thomas B | Chief Executive Officer | 10/18/2018 | 1,030,443 |
| Neff Thomas B | Chief Executive Officer | 10/02/2018 | 37,152 |
| Neff Thomas B | Chief Executive Officer | 10/03/2018 | 37,148 |
| Neff Thomas B | Chief Executive Officer | 10/02/2018 | 1,111,915 |
| Neff Thomas B | Chief Executive Officer | 10/03/2018 | 54,608 |
| Neff Thomas B | Chief Executive Officer | 10/03/2018 | 1,123,690 |
| Neff Thomas B | Chief Executive Officer | 10/02/2018 | 54,085 |
| Rosenkranz Roberto Pedro | Director | 09/20/2018 | 9,775 |
| Rosenkranz Roberto Pedro | Director | 09/20/2018 | 56,950 |
| Neff Thomas B | Chief Executive Officer | 09/19/2018 | 37,152 |
| Neff Thomas B | Chief Executive Officer | 09/20/2018 | 37,152 |
| Neff Thomas B | Chief Executive Officer | 09/19/2018 | 1,074,772 |
| Neff Thomas B | Chief Executive Officer | 09/20/2018 | 54,041 |
| Neff Thomas B | Chief Executive Officer | 09/20/2018 | 1,110,165 |
| Neff Thomas B | Chief Executive Officer | 09/19/2018 | 52,220 |
| Kurkijarvi Kalevi | Director | 09/17/2018 | 11,600 |
| Kurkijarvi Kalevi | Director | 09/17/2018 | 235,456 |
| Cotroneo Pat | SVP, Finance and CFO | 09/12/2018 | 30,450 |
| Cotroneo Pat | SVP, Finance and CFO | 09/13/2018 | 137,921 |
| Routti Jorma | Director | 09/10/2018 | 110,040 |
| Cotroneo Pat | SVP, Finance and CFO | 09/10/2018 | 57,981 |
| Routti Jorma | Director | 09/10/2018 | 343,837 |
| Neff Thomas B | Chief Executive Officer | 09/07/2018 | 37,152 |
| Neff Thomas B | Chief Executive Officer | 09/06/2018 | 37,152 |
| Neff Thomas B | Chief Executive Officer | 09/06/2018 | 53,216 |
| Neff Thomas B | Chief Executive Officer | 09/06/2018 | 1,101,599 |
| Neff Thomas B | Chief Executive Officer | 09/07/2018 | 52,084 |
| Neff Thomas B | Chief Executive Officer | 09/07/2018 | 1,072,600 |
| Yu K Peony | Chief Medical Officer | 09/06/2018 | 135,686 |
| Neff Thomas B | Chief Executive Officer | 09/06/2018 | 365,173 |
| Neff Thomas B | Chief Executive Officer | 09/04/2018 | 139,560 |
| Cotroneo Pat | SVP, Finance and CFO | 09/06/2018 | 130,472 |
| Cotroneo Pat | SVP, Finance and CFO | 09/04/2018 | 60,684 |
| Yu K Peony | Chief Medical Officer | 09/04/2018 | 60,684 |
| Yu K Peony | Chief Medical Officer | 08/31/2018 | 83,585 |
| Tamura Toshinari | Director | 08/22/2018 | 228,600 |
| Tamura Toshinari | Director | 08/22/2018 | 727,800 |
| Neff Thomas B | Chief Executive Officer | 08/21/2018 | 37,152 |
| Neff Thomas B | Chief Executive Officer | 08/20/2018 | 37,152 |
| Neff Thomas B | Chief Executive Officer | 08/21/2018 | 1,144,320 |
| Neff Thomas B | Chief Executive Officer | 08/20/2018 | 54,915 |
| Neff Thomas B | Chief Executive Officer | 08/20/2018 | 1,132,909 |
| Neff Thomas B | Chief Executive Officer | 08/21/2018 | 55,622 |
| Rosenkranz Roberto Pedro | Director | 08/16/2018 | 9,775 |
| Rosenkranz Roberto Pedro | Director | 08/16/2018 | 60,279 |
| Kurkijarvi Kalevi | Director | 08/16/2018 | 11,600 |
| Kurkijarvi Kalevi | Director | 08/16/2018 | 241,128 |
| Routti Jorma | Director | 08/09/2018 | 108,000 |
| Routti Jorma | Director | 08/09/2018 | 359,579 |
| Neff Thomas B | Chief Executive Officer | 08/02/2018 | 37,152 |
| Neff Thomas B | Chief Executive Officer | 08/01/2018 | 37,152 |
| Neff Thomas B | Chief Executive Officer | 08/01/2018 | 57,907 |
| Neff Thomas B | Chief Executive Officer | 08/01/2018 | 1,192,847 |
| Neff Thomas B | Chief Executive Officer | 08/02/2018 | 57,724 |
| Neff Thomas B | Chief Executive Officer | 08/02/2018 | 1,188,723 |
| Rosenkranz Roberto Pedro | Director | 07/19/2018 | 9,775 |
| Rosenkranz Roberto Pedro | Director | 07/19/2018 | 64,900 |
| Neff Thomas B | Chief Executive Officer | 07/19/2018 | 37,152 |
| Neff Thomas B | Chief Executive Officer | 07/18/2018 | 37,152 |
| Neff Thomas B | Chief Executive Officer | 07/19/2018 | 59,000 |
| Neff Thomas B | Chief Executive Officer | 07/19/2018 | 1,216,072 |
| Neff Thomas B | Chief Executive Officer | 07/18/2018 | 60,111 |
| Neff Thomas B | Chief Executive Officer | 07/18/2018 | 1,237,599 |
| Kurkijarvi Kalevi | Director | 07/19/2018 | 11,600 |
| Kurkijarvi Kalevi | Director | 07/19/2018 | 257,400 |
| Routti Jorma | Director | 07/09/2018 | 108,000 |
| Routti Jorma | Director | 07/09/2018 | 406,260 |
| Yu K Peony | Chief Medical Officer | 07/03/2018 | 228,026 |
| Yu K Peony | Chief Medical Officer | 07/03/2018 | 1,016,925 |
| Schoeneck James A | Director | 07/03/2018 | 22,153 |
| Schoeneck James A | Director | 07/03/2018 | 496,535 |
| Neff Thomas B | Chief Executive Officer | 07/05/2018 | 37,152 |
| Neff Thomas B | Chief Executive Officer | 07/06/2018 | 37,152 |
| Neff Thomas B | Chief Executive Officer | 07/06/2018 | 60,608 |
| Neff Thomas B | Chief Executive Officer | 07/06/2018 | 1,243,853 |
| Neff Thomas B | Chief Executive Officer | 07/05/2018 | 58,762 |
| Neff Thomas B | Chief Executive Officer | 07/05/2018 | 1,212,543 |
| Schoeneck James A | Director | 06/22/2018 | 12,647 |
| Schoeneck James A | Director | 06/22/2018 | 283,465 |
| Rosenkranz Roberto Pedro | Director | 06/21/2018 | 9,775 |
| Rosenkranz Roberto Pedro | Director | 06/21/2018 | 63,650 |
| Neff Thomas B | Chief Executive Officer | 06/21/2018 | 37,152 |
| Neff Thomas B | Chief Executive Officer | 06/20/2018 | 37,152 |
| Neff Thomas B | Chief Executive Officer | 06/20/2018 | 58,389 |
| Neff Thomas B | Chief Executive Officer | 06/20/2018 | 1,201,935 |
| Neff Thomas B | Chief Executive Officer | 06/21/2018 | 58,385 |
| Neff Thomas B | Chief Executive Officer | 06/21/2018 | 1,202,919 |
| Kurkijarvi Kalevi | Director | 06/18/2018 | 11,600 |
| Kurkijarvi Kalevi | Director | 06/18/2018 | 232,760 |
| Yu K Peony | Chief Medical Officer | 06/14/2018 | 202,582 |
| Cotroneo Pat | SVP, Finance and CFO | 06/14/2018 | 196,850 |
| Cotroneo Pat | SVP, Finance and CFO | 06/14/2018 | 465,000 |
| Cotroneo Pat | SVP, Finance and CFO | 06/13/2018 | 133,806 |
| Routti Jorma | Director | 06/11/2018 | 58,650 |
| Routti Jorma | Director | 06/11/2018 | 344,880 |
| Yu K Peony | Chief Medical Officer | 06/06/2018 | 134,085 |
| Neff Thomas B | Chief Executive Officer | 06/06/2018 | 360,712 |
| Cotroneo Pat | SVP, Finance and CFO | 06/06/2018 | 128,878 |
| Cotroneo Pat | SVP, Finance and CFO | 06/08/2018 | 56,161 |
| Yu K Peony | Chief Medical Officer | 06/01/2018 | 53,672 |
| Neff Thomas B | Chief Executive Officer | 06/01/2018 | 123,612 |
| Neff Thomas B | Chief Executive Officer | 06/04/2018 | 37,152 |
| Neff Thomas B | Chief Executive Officer | 06/05/2018 | 37,152 |
| Neff Thomas B | Chief Executive Officer | 06/04/2018 | 50,305 |
| Neff Thomas B | Chief Executive Officer | 06/04/2018 | 1,033,898 |
| Neff Thomas B | Chief Executive Officer | 06/05/2018 | 50,435 |
| Neff Thomas B | Chief Executive Officer | 06/05/2018 | 1,039,959 |
| Cotroneo Pat | SVP, Finance and CFO | 06/01/2018 | 53,672 |
| Cotroneo Pat | SVP, Finance and CFO | 06/04/2018 | 116,592 |
| Cotroneo Pat | SVP, Finance and CFO | 06/04/2018 | 331,677 |
| Cotroneo Pat | SVP, Finance and CFO | 05/21/2018 | 332,668 |
| Cotroneo Pat | SVP, Finance and CFO | 05/21/2018 | 824,884 |
| Rosenkranz Roberto Pedro | Director | 05/17/2018 | 9,775 |
| Rosenkranz Roberto Pedro | Director | 05/17/2018 | 52,200 |
| Neff Thomas B | Chief Executive Officer | 05/17/2018 | 37,152 |
| Neff Thomas B | Chief Executive Officer | 05/16/2018 | 37,152 |
| Neff Thomas B | Chief Executive Officer | 05/17/2018 | 976,322 |
| Neff Thomas B | Chief Executive Officer | 05/16/2018 | 47,773 |
| Neff Thomas B | Chief Executive Officer | 05/16/2018 | 982,545 |
| Neff Thomas B | Chief Executive Officer | 05/17/2018 | 47,387 |
| Kurkijarvi Kalevi | Director | 05/17/2018 | 11,600 |
| Kurkijarvi Kalevi | Director | 05/17/2018 | 207,320 |
| Routti Jorma | Director | 05/09/2018 | 58,650 |
| Routti Jorma | Director | 05/09/2018 | 282,600 |
| Neff Thomas B | Chief Executive Officer | 05/02/2018 | 37,152 |
| Neff Thomas B | Chief Executive Officer | 05/03/2018 | 37,152 |
| Neff Thomas B | Chief Executive Officer | 05/02/2018 | 894,537 |
| Neff Thomas B | Chief Executive Officer | 05/03/2018 | 42,806 |
| Neff Thomas B | Chief Executive Officer | 05/03/2018 | 883,570 |
| Neff Thomas B | Chief Executive Officer | 05/02/2018 | 43,440 |
| Cotroneo Pat | VP, Finance and CFO | 04/23/2018 | 97,295 |
| Rosenkranz Roberto Pedro | Director | 04/19/2018 | 9,775 |
| Rosenkranz Roberto Pedro | Director | 04/19/2018 | 47,700 |
| Kurkijarvi Kalevi | Director | 04/19/2018 | 11,600 |
| Kurkijarvi Kalevi | Director | 04/19/2018 | 190,760 |
| Neff Thomas B | Chief Executive Officer | 04/18/2018 | 37,152 |
| Neff Thomas B | Chief Executive Officer | 04/17/2018 | 37,152 |
| Neff Thomas B | Chief Executive Officer | 04/18/2018 | 44,615 |
| Neff Thomas B | Chief Executive Officer | 04/18/2018 | 920,484 |
| Neff Thomas B | Chief Executive Officer | 04/17/2018 | 44,560 |
| Neff Thomas B | Chief Executive Officer | 04/17/2018 | 914,971 |
| Yu K Peony | Chief Medical Officer | 04/16/2018 | 358,553 |
| Routti Jorma | Director | 04/09/2018 | 35,700 |
| Routti Jorma | Director | 04/09/2018 | 279,554 |
| Neff Thomas B | Chief Executive Officer | 04/04/2018 | 37,152 |
| Neff Thomas B | Chief Executive Officer | 04/05/2018 | 37,152 |
| Neff Thomas B | Chief Executive Officer | 04/04/2018 | 41,909 |
| Neff Thomas B | Chief Executive Officer | 04/04/2018 | 861,362 |
| Neff Thomas B | Chief Executive Officer | 04/05/2018 | 41,677 |
| Neff Thomas B | Chief Executive Officer | 04/05/2018 | 861,945 |
| Neff Thomas B | Chief Executive Officer | 03/20/2018 | 32,551 |
| Neff Thomas B | Chief Executive Officer | 03/21/2018 | 32,551 |
| Neff Thomas B | Chief Executive Officer | 03/21/2018 | 1,014,464 |
| Neff Thomas B | Chief Executive Officer | 03/20/2018 | 46,552 |
| Neff Thomas B | Chief Executive Officer | 03/20/2018 | 958,604 |
| Yu K Peony | Chief Medical Officer | 03/14/2018 | 526,201 |
| Rosenkranz Roberto Pedro | Director | 03/15/2018 | 9,775 |
| Rosenkranz Roberto Pedro | Director | 03/15/2018 | 52,339 |
| Kurkijarvi Kalevi | Director | 03/15/2018 | 11,600 |
| Kurkijarvi Kalevi | Director | 03/15/2018 | 209,764 |
| Tamura Toshinari | Director | 03/13/2018 | 436,080 |
| Tamura Toshinari | Director | 03/13/2018 | 1,280,898 |
| Cotroneo Pat | VP, Finance and CFO | 03/15/2018 | 926,768 |
| Cotroneo Pat | VP, Finance and CFO | 03/15/2018 | 1,896,923 |
| Cotroneo Pat | VP, Finance and CFO | 03/13/2018 | 323,947 |
| RIGGS RORY B | Director | 03/13/2018 | 671,743 |
| RIGGS RORY B | Director | 03/12/2018 | 1,082,721 |
| KEARNS THOMAS F JR | Director | 03/12/2018 | 64,800 |
| KEARNS THOMAS F JR | Director | 03/12/2018 | 990,000 |
| RIGGS RORY B | Director | 03/09/2018 | 1,276,954 |
| Yu K Peony | Chief Medical Officer | 03/06/2018 | 271,231 |
| Neff Thomas B | Chief Executive Officer | 03/06/2018 | 867,456 |
| Neff Thomas B | Chief Executive Officer | 03/07/2018 | 24,123 |
| Neff Thomas B | Chief Executive Officer | 03/08/2018 | 28,392 |
| Neff Thomas B | Chief Executive Officer | 03/07/2018 | 1,002,651 |
| Neff Thomas B | Chief Executive Officer | 03/08/2018 | 48,884 |
| Neff Thomas B | Chief Executive Officer | 03/08/2018 | 1,005,991 |
| Neff Thomas B | Chief Executive Officer | 03/07/2018 | 48,726 |
| Cotroneo Pat | VP, Finance and CFO | 03/06/2018 | 312,304 |
| Cotroneo Pat | VP, Finance and CFO | 03/08/2018 | 100,617 |
| Yu K Peony | Chief Medical Officer | 03/01/2018 | 71,270 |
| Neff Thomas B | Chief Executive Officer | 03/01/2018 | 244,802 |
| Cotroneo Pat | VP, Finance and CFO | 03/01/2018 | 102,207 |
| Neff Thomas B | Chief Executive Officer | 02/22/2018 | 24,123 |
| Neff Thomas B | Chief Executive Officer | 02/23/2018 | 24,123 |
| Neff Thomas B | Chief Executive Officer | 02/22/2018 | 1,077,350 |
| Neff Thomas B | Chief Executive Officer | 02/23/2018 | 51,767 |
| Neff Thomas B | Chief Executive Officer | 02/23/2018 | 1,064,445 |
| Neff Thomas B | Chief Executive Officer | 02/22/2018 | 52,233 |
| Neff Thomas B | Chief Executive Officer | 12/19/2016 | 99,997 |
| Routti Jorma | Director | 02/14/2018 | 21,000 |
| Routti Jorma | Director | 02/15/2018 | 21,000 |
| Routti Jorma | Director | 02/15/2018 | 334,308 |
| Routti Jorma | Director | 02/14/2018 | 329,258 |
| Rosenkranz Roberto Pedro | Director | 02/15/2018 | 9,775 |
| Rosenkranz Roberto Pedro | Director | 02/15/2018 | 55,898 |
| Cotroneo Pat | VP, Finance and CFO | 02/15/2018 | 1,076,240 |
| Cotroneo Pat | VP, Finance and CFO | 02/16/2018 | 71,280 |
| Cotroneo Pat | VP, Finance and CFO | 02/16/2018 | 222,866 |
| Cotroneo Pat | VP, Finance and CFO | 02/15/2018 | 2,547,213 |
| Kurkijarvi Kalevi | Director | 02/15/2018 | 17,400 |
| Kurkijarvi Kalevi | Director | 02/15/2018 | 334,119 |
| Yu K Peony | Chief Medical Officer | 02/08/2018 | 404,778 |
| Yu K Peony | Chief Medical Officer | 01/29/2018 | 620,000 |
| Neff Thomas B | Chief Executive Officer | 01/29/2018 | 25,766 |
| Neff Thomas B | Chief Executive Officer | 01/29/2018 | 1,164,718 |
| Neff Thomas B | Chief Executive Officer | 01/30/2018 | 25,615 |
| Neff Thomas B | Chief Executive Officer | 01/30/2018 | 1,155,996 |
| Rosenkranz Roberto Pedro | Director | 01/26/2018 | 360,000 |
| Rosenkranz Roberto Pedro | Director | 01/22/2018 | 3,550 |
| Rosenkranz Roberto Pedro | Director | 01/23/2018 | 96,450 |
| Cotroneo Pat | VP, Finance and CFO | 01/22/2018 | 450,000 |
| Cotroneo Pat | VP, Finance and CFO | 01/22/2018 | 1,217,954 |
| Rosenkranz Roberto Pedro | Director | 01/18/2018 | 9,775 |
| Rosenkranz Roberto Pedro | Director | 01/18/2018 | 284,695 |
| Neff Thomas B | Chief Executive Officer | 01/19/2018 | 19,692 |
| Neff Thomas B | Chief Executive Officer | 01/19/2018 | 893,552 |
| Neff Thomas B | Chief Executive Officer | 01/18/2018 | 19,859 |
| Neff Thomas B | Chief Executive Officer | 01/18/2018 | 900,411 |
| Kurkijarvi Kalevi | Director | 01/18/2018 | 17,400 |
| Kurkijarvi Kalevi | Director | 01/18/2018 | 284,268 |
| Neff Thomas B | Chief Executive Officer | 01/05/2018 | 19,161 |
| Neff Thomas B | Chief Executive Officer | 01/05/2018 | 876,412 |
| Neff Thomas B | Chief Executive Officer | 01/04/2018 | 20,436 |
| Neff Thomas B | Chief Executive Officer | 01/04/2018 | 923,544 |
| Neff Thomas B | Chief Executive Officer | 12/29/2017 | 916,381 |
| Neff Thomas B | Chief Executive Officer | 12/28/2017 | 20,189 |
| Neff Thomas B | Chief Executive Officer | 12/28/2017 | 912,646 |
| Neff Thomas B | Chief Executive Officer | 12/29/2017 | 20,214 |
| Neff Thomas B | Chief Executive Officer | 12/21/2017 | 260,413 |
| Neff Thomas B | Chief Executive Officer | 12/20/2017 | 18,242 |
| Neff Thomas B | Chief Executive Officer | 12/20/2017 | 833,809 |
| Neff Thomas B | Chief Executive Officer | 12/21/2017 | 18,902 |
| Neff Thomas B | Chief Executive Officer | 12/21/2017 | 854,702 |
| Kurkijarvi Kalevi | Director | 12/18/2017 | 85,600 |
| Yu K Peony | Chief Medical Officer | 12/14/2017 | 124,589 |
| Neff Thomas B | Chief Executive Officer | 12/14/2017 | 807,265 |
| Neff Thomas B | Chief Executive Officer | 12/15/2017 | 17,343 |
| Neff Thomas B | Chief Executive Officer | 12/15/2017 | 787,950 |
| Neff Thomas B | Chief Executive Officer | 12/14/2017 | 17,651 |
| Kurkijarvi Kalevi | Director | 12/12/2017 | 34,800 |
| Kurkijarvi Kalevi | Director | 12/12/2017 | 533,400 |
| Cotroneo Pat | VP, Finance and CFO | 12/11/2017 | 131,146 |
| Yu K Peony | Chief Medical Officer | 12/06/2017 | 51,622 |
| Neff Thomas B | Chief Executive Officer | 12/06/2017 | 146,256 |
| Cotroneo Pat | VP, Finance and CFO | 12/06/2017 | 51,622 |
| Lema Gerald | Director | 12/04/2017 | 163,450 |
| Yu K Peony | Chief Medical Officer | 12/01/2017 | 92,320 |
| Neff Thomas B | Chief Executive Officer | 12/01/2017 | 221,086 |
| Cotroneo Pat | VP, Finance and CFO | 12/01/2017 | 92,320 |
| Routti Jorma | Director | 12/01/2017 | 17,400 |
| Routti Jorma | Director | 11/30/2017 | 17,400 |
| Routti Jorma | Director | 11/30/2017 | 283,080 |
| Routti Jorma | Director | 12/01/2017 | 283,920 |
| Kurkijarvi Kalevi | Director | 11/17/2017 | 93,300 |
| KEARNS THOMAS F JR | Director | 11/15/2017 | 42,300 |
| KEARNS THOMAS F JR | Director | 11/15/2017 | 813,960 |
| Neff Thomas B | Chief Executive Officer | 11/17/2017 | 881,842 |
| Neff Thomas B | Chief Executive Officer | 11/16/2017 | 19,542 |
| Neff Thomas B | Chief Executive Officer | 11/16/2017 | 880,713 |
| Neff Thomas B | Chief Executive Officer | 11/17/2017 | 19,542 |
| Cotroneo Pat | VP, Finance and CFO | 11/09/2017 | 93,980 |
| Yu K Peony | Chief Medical Officer | 11/06/2017 | 415,243 |
| Neff Thomas B | Chief Executive Officer | 10/31/2017 | 1,055,305 |
| Neff Thomas B | Chief Executive Officer | 10/30/2017 | 23,342 |
| Neff Thomas B | Chief Executive Officer | 10/30/2017 | 1,066,415 |
| Neff Thomas B | Chief Executive Officer | 10/31/2017 | 23,387 |
| Kurkijarvi Kalevi | Director | 10/17/2017 | 104,480 |
| Neff Thomas B | Chief Executive Officer | 10/16/2017 | 1,036,289 |
| Neff Thomas B | Chief Executive Officer | 10/17/2017 | 23,079 |
| Neff Thomas B | Chief Executive Officer | 10/17/2017 | 1,043,784 |
| Neff Thomas B | Chief Executive Officer | 10/16/2017 | 22,719 |
| Yu K Peony | Chief Medical Officer | 10/04/2017 | 218,625 |
| Yu K Peony | Chief Medical Officer | 10/04/2017 | 900,000 |
| Yu K Peony | Chief Medical Officer | 10/02/2017 | 437,250 |
| Yu K Peony | Chief Medical Officer | 10/02/2017 | 2,185,000 |
| Neff Thomas B | Chief Executive Officer | 10/03/2017 | 1,052,919 |
| Neff Thomas B | Chief Executive Officer | 10/02/2017 | 22,965 |
| Neff Thomas B | Chief Executive Officer | 10/02/2017 | 1,029,072 |
| Neff Thomas B | Chief Executive Officer | 10/03/2017 | 23,357 |
| Neff Thomas B | Chief Executive Officer | 09/20/2017 | 22,355 |
| Neff Thomas B | Chief Executive Officer | 09/20/2017 | 1,014,741 |
| Neff Thomas B | Chief Executive Officer | 09/19/2017 | 22,091 |
| Neff Thomas B | Chief Executive Officer | 09/19/2017 | 1,006,299 |
| Kurkijarvi Kalevi | Director | 09/18/2017 | 105,100 |
| Kurkijarvi Kalevi | Director | 08/17/2017 | 81,480 |
| Yu K Peony | Chief Medical Officer | 09/14/2017 | 145,401 |
| RIGGS RORY B | Director | 09/13/2017 | 1,298,000 |
| Neff Thomas B | Chief Executive Officer | 09/14/2017 | 21,715 |
| Neff Thomas B | Chief Executive Officer | 09/14/2017 | 983,553 |
| Neff Thomas B | Chief Executive Officer | 09/13/2017 | 21,584 |
| Neff Thomas B | Chief Executive Officer | 09/13/2017 | 969,422 |
| Cotroneo Pat | VP, Finance and CFO | 09/11/2017 | 140,982 |
| Yu K Peony | Chief Medical Officer | 09/06/2017 | 55,363 |
| Yu K Peony | Chief Medical Officer | 09/01/2017 | 95,991 |
| Neff Thomas B | Chief Executive Officer | 09/06/2017 | 156,854 |
| Neff Thomas B | Chief Executive Officer | 09/01/2017 | 229,712 |
| Cotroneo Pat | VP, Finance and CFO | 09/06/2017 | 55,363 |
| Cotroneo Pat | VP, Finance and CFO | 09/01/2017 | 95,991 |
| Routti Jorma | Director | 09/01/2017 | 21,600 |
| Routti Jorma | Director | 08/31/2017 | 21,600 |
| Routti Jorma | Director | 09/01/2017 | 287,580 |
| Routti Jorma | Director | 08/31/2017 | 280,680 |
| Neff Thomas B | Chief Executive Officer | 08/29/2017 | 41,181 |
| Neff Thomas B | Chief Executive Officer | 08/28/2017 | 44,415 |
| Neff Thomas B | Chief Executive Officer | 08/29/2017 | 18,660 |
| Neff Thomas B | Chief Executive Officer | 08/29/2017 | 839,313 |
| Neff Thomas B | Chief Executive Officer | 08/28/2017 | 18,016 |
| Neff Thomas B | Chief Executive Officer | 08/28/2017 | 813,456 |
| Yu K Peony | Chief Medical Officer | 08/21/2017 | 307,725 |
| Yu K Peony | Chief Medical Officer | 08/08/2017 | 291,500 |
| Yu K Peony | Chief Medical Officer | 08/08/2017 | 1,896,861 |
| Cotroneo Pat | VP, Finance and CFO | 08/08/2017 | 1,273,875 |
| Cotroneo Pat | VP, Finance and CFO | 08/08/2017 | 4,808,038 |
| Yu K Peony | Chief Medical Officer | 08/01/2017 | 145,750 |
| Yu K Peony | Chief Medical Officer | 08/01/2017 | 334,800 |
| Cotroneo Pat | VP, Finance and CFO | 08/02/2017 | 170,445 |
| Cotroneo Pat | VP, Finance and CFO | 08/01/2017 | 25,543 |
| Cotroneo Pat | VP, Finance and CFO | 08/02/2017 | 708,061 |
| Cotroneo Pat | VP, Finance and CFO | 08/01/2017 | 254,904 |
| Neff Thomas B | Chief Executive Officer | 07/24/2017 | 44,415 |
| Neff Thomas B | Chief Executive Officer | 07/25/2017 | 44,415 |
| Neff Thomas B | Chief Executive Officer | 07/24/2017 | 14,668 |
| Neff Thomas B | Chief Executive Officer | 07/24/2017 | 662,634 |
| Neff Thomas B | Chief Executive Officer | 07/25/2017 | 14,676 |
| Neff Thomas B | Chief Executive Officer | 07/25/2017 | 663,768 |
| Kurkijarvi Kalevi | Director | 07/17/2017 | 66,900 |
| Yu K Peony | Chief Medical Officer | 07/10/2017 | 164,900 |
| Neff Thomas B | Chief Executive Officer | 07/07/2017 | 44,415 |
| Neff Thomas B | Chief Executive Officer | 07/06/2017 | 44,415 |
| Neff Thomas B | Chief Executive Officer | 07/07/2017 | 627,858 |
| Neff Thomas B | Chief Executive Officer | 07/06/2017 | 14,000 |
| Neff Thomas B | Chief Executive Officer | 07/06/2017 | 633,795 |
| Neff Thomas B | Chief Executive Officer | 07/07/2017 | 13,894 |
| Cotroneo Pat | VP, Finance and CFO | 07/06/2017 | 11,600 |
| Cotroneo Pat | VP, Finance and CFO | 07/06/2017 | 136,000 |
| Cotroneo Pat | VP, Finance and CFO | 06/22/2017 | 8,700 |
| Cotroneo Pat | VP, Finance and CFO | 06/22/2017 | 96,000 |
| Neff Thomas B | Chief Executive Officer | 06/22/2017 | 44,415 |
| Neff Thomas B | Chief Executive Officer | 06/21/2017 | 44,415 |
| Neff Thomas B | Chief Executive Officer | 06/22/2017 | 13,384 |
| Neff Thomas B | Chief Executive Officer | 06/22/2017 | 602,476 |
| Neff Thomas B | Chief Executive Officer | 06/21/2017 | 13,050 |
| Neff Thomas B | Chief Executive Officer | 06/21/2017 | 588,735 |
| Cotroneo Pat | VP, Finance and CFO | 06/19/2017 | 12,925 |
| Cotroneo Pat | VP, Finance and CFO | 06/19/2017 | 165,000 |
| Kurkijarvi Kalevi | Director | 06/15/2017 | 57,000 |
| Neff Thomas B | Chief Executive Officer | 06/16/2017 | 44,415 |
| Neff Thomas B | Chief Executive Officer | 06/15/2017 | 27,469 |
| Neff Thomas B | Chief Executive Officer | 06/15/2017 | 12,239 |
| Neff Thomas B | Chief Executive Officer | 06/15/2017 | 552,825 |
| Neff Thomas B | Chief Executive Officer | 06/16/2017 | 12,364 |
| Neff Thomas B | Chief Executive Officer | 06/16/2017 | 558,306 |
| Yu K Peony | Chief Medical Officer | 06/14/2017 | 107,723 |
| Cotroneo Pat | VP, Finance and CFO | 06/12/2017 | 83,116 |
| Tamura Toshinari | Director | 06/12/2017 | 135,150 |
| Tamura Toshinari | Director | 06/09/2017 | 59,850 |
| Tamura Toshinari | Director | 06/12/2017 | 428,550 |
| Tamura Toshinari | Director | 06/09/2017 | 438,000 |
| KEARNS THOMAS F JR | Director | 06/06/2017 | 175,950 |
| KEARNS THOMAS F JR | Director | 06/06/2017 | 516,780 |
| Cotroneo Pat | VP, Finance and CFO | 06/06/2017 | 33,437 |
| Yu K Peony | Chief Medical Officer | 06/06/2017 | 24,082 |
| Neff Thomas B | Chief Executive Officer | 06/06/2017 | 94,732 |
| Yu K Peony | Chief Medical Officer | 06/01/2017 | 38,916 |
| Neff Thomas B | Chief Executive Officer | 06/01/2017 | 129,416 |
| Neff Thomas B | Chief Executive Officer | 05/31/2017 | 44,415 |
| Neff Thomas B | Chief Executive Officer | 05/30/2017 | 44,415 |
| Neff Thomas B | Chief Executive Officer | 05/30/2017 | 10,993 |
| Neff Thomas B | Chief Executive Officer | 05/30/2017 | 499,824 |
| Neff Thomas B | Chief Executive Officer | 05/31/2017 | 10,881 |
| Neff Thomas B | Chief Executive Officer | 05/31/2017 | 490,833 |
| Cotroneo Pat | VP, Finance and CFO | 06/01/2017 | 52,937 |
| Cotroneo Pat | VP, Finance and CFO | 05/30/2017 | 29,000 |
| Kurkijarvi Kalevi | Director | 05/16/2017 | 54,800 |
| Neff Thomas B | Chief Executive Officer | 05/16/2017 | 44,415 |
| Neff Thomas B | Chief Executive Officer | 05/15/2017 | 44,415 |
| Neff Thomas B | Chief Executive Officer | 05/16/2017 | 11,566 |
| Neff Thomas B | Chief Executive Officer | 05/16/2017 | 522,396 |
| Neff Thomas B | Chief Executive Officer | 05/15/2017 | 11,625 |
| Neff Thomas B | Chief Executive Officer | 05/15/2017 | 524,475 |
| Yu K Peony | Chief Medical Officer | 05/10/2017 | 131,890 |
| Yu K Peony | Chief Medical Officer | 04/25/2017 | 72,875 |
| Yu K Peony | Chief Medical Officer | 04/25/2017 | 140,000 |
| Cotroneo Pat | VP, Finance and CFO | 04/25/2017 | 15,275 |
| Cotroneo Pat | VP, Finance and CFO | 04/25/2017 | 182,000 |
| Neff Thomas B | Chief Executive Officer | 04/25/2017 | 59,145 |
| Neff Thomas B | Chief Executive Officer | 04/24/2017 | 76,073 |
| Neff Thomas B | Chief Executive Officer | 04/25/2017 | 519,561 |
| Neff Thomas B | Chief Executive Officer | 04/24/2017 | 11,056 |
| Neff Thomas B | Chief Executive Officer | 04/24/2017 | 498,015 |
| Neff Thomas B | Chief Executive Officer | 04/25/2017 | 11,566 |
| Kurkijarvi Kalevi | Director | 04/17/2017 | 50,500 |
| Neff Thomas B | Chief Executive Officer | 04/13/2017 | 76,073 |
| Neff Thomas B | Chief Executive Officer | 04/12/2017 | 76,073 |
| Neff Thomas B | Chief Executive Officer | 04/13/2017 | 470,799 |
| Neff Thomas B | Chief Executive Officer | 04/12/2017 | 10,270 |
| Neff Thomas B | Chief Executive Officer | 04/12/2017 | 466,172 |
| Neff Thomas B | Chief Executive Officer | 04/13/2017 | 10,429 |
| Neff Thomas B | Chief Executive Officer | 04/04/2017 | 76,073 |
| Neff Thomas B | Chief Executive Officer | 04/03/2017 | 76,073 |
| Neff Thomas B | Chief Executive Officer | 04/04/2017 | 450,765 |
| Neff Thomas B | Chief Executive Officer | 04/03/2017 | 9,999 |
| Neff Thomas B | Chief Executive Officer | 04/03/2017 | 453,411 |
| Neff Thomas B | Chief Executive Officer | 04/04/2017 | 9,948 |
| Neff Thomas B | Chief Executive Officer | 03/21/2017 | 76,073 |
| Neff Thomas B | Chief Executive Officer | 03/20/2017 | 76,073 |
| Neff Thomas B | Chief Executive Officer | 03/20/2017 | 10,417 |
| Neff Thomas B | Chief Executive Officer | 03/20/2017 | 470,232 |
| Neff Thomas B | Chief Executive Officer | 03/21/2017 | 9,856 |
| Neff Thomas B | Chief Executive Officer | 03/21/2017 | 449,800 |
| Yu K Peony | Chief Medical Officer | 03/14/2017 | 199,458 |
| Neff Thomas B | Chief Executive Officer | 03/14/2017 | 43,703 |
| Neff Thomas B | Chief Executive Officer | 03/15/2017 | 43,703 |
| Neff Thomas B | Chief Executive Officer | 03/14/2017 | 10,458 |
| Neff Thomas B | Chief Executive Officer | 03/14/2017 | 473,631 |
| Neff Thomas B | Chief Executive Officer | 03/15/2017 | 484,382 |
| Cotroneo Pat | VP, Finance and CFO | 03/10/2017 | 198,630 |
| Yu K Peony | Chief Medical Officer | 03/06/2017 | 119,829 |
| Neff Thomas B | Chief Executive Officer | 03/06/2017 | 449,608 |
| Cotroneo Pat | VP, Finance and CFO | 03/06/2017 | 119,829 |
| Cotroneo Pat | VP, Finance and CFO | 03/02/2017 | 13,160 |
| Cotroneo Pat | VP, Finance and CFO | 03/01/2017 | 2,115 |
| Cotroneo Pat | VP, Finance and CFO | 03/02/2017 | 145,600 |
| Cotroneo Pat | VP, Finance and CFO | 03/01/2017 | 23,400 |
| Kurkijarvi Kalevi | Director | 02/16/2017 | 48,900 |
| Neff Thomas B | Chief Executive Officer | 02/14/2017 | 76,073 |
| Neff Thomas B | Chief Executive Officer | 02/13/2017 | 76,073 |
| Neff Thomas B | Chief Executive Officer | 02/14/2017 | 451,710 |
| Neff Thomas B | Chief Executive Officer | 02/13/2017 | 10,036 |
| Neff Thomas B | Chief Executive Officer | 02/13/2017 | 453,033 |
| Neff Thomas B | Chief Executive Officer | 02/14/2017 | 9,986 |
| Neff Thomas B | Chief Executive Officer | 02/09/2017 | 56,716 |
| Neff Thomas B | Chief Executive Officer | 02/08/2017 | 56,716 |
| Neff Thomas B | Chief Executive Officer | 02/08/2017 | 435,244 |
| Neff Thomas B | Chief Executive Officer | 02/09/2017 | 451,497 |
| Neff Thomas B | Chief Executive Officer | 01/26/2017 | 56,716 |
| Neff Thomas B | Chief Executive Officer | 01/27/2017 | 56,716 |
| Neff Thomas B | Chief Executive Officer | 01/27/2017 | 437,701 |
| Neff Thomas B | Chief Executive Officer | 01/26/2017 | 442,615 |
| Kurkijarvi Kalevi | Director | 01/19/2017 | 49,800 |
| Cotroneo Pat | VP, Finance and CFO | 01/11/2017 | 15,275 |
| Cotroneo Pat | VP, Finance and CFO | 01/11/2017 | 156,000 |
| Neff Thomas B | Chief Executive Officer | 01/11/2017 | 56,716 |
| Neff Thomas B | Chief Executive Officer | 01/12/2017 | 56,716 |
| Neff Thomas B | Chief Executive Officer | 01/12/2017 | 457,324 |
| Neff Thomas B | Chief Executive Officer | 01/11/2017 | 444,198 |
| Yu K Peony | Chief Medical Officer | 01/10/2017 | 117,800 |
| Neff Thomas B | Chief Executive Officer | 12/28/2016 | 56,708 |
| Neff Thomas B | Chief Executive Officer | 12/27/2016 | 56,716 |
| Neff Thomas B | Chief Executive Officer | 12/28/2016 | 391,020 |
| Neff Thomas B | Chief Executive Officer | 12/27/2016 | 392,910 |
| RIGGS RORY B | Director | 12/16/2016 | 417,310 |
| Yu K Peony | Chief Medical Officer | 12/14/2016 | 48,404 |
| Cotroneo Pat | VP, Finance and CFO | 12/12/2016 | 51,685 |
| Neff Thomas B | Chief Executive Officer | 12/13/2016 | 56,716 |
| Neff Thomas B | Chief Executive Officer | 12/12/2016 | 56,716 |
| Neff Thomas B | Chief Executive Officer | 12/13/2016 | 396,850 |
| Neff Thomas B | Chief Executive Officer | 12/12/2016 | 405,978 |
| Yu K Peony | Chief Medical Officer | 12/01/2016 | 28,975 |
| Neff Thomas B | Chief Executive Officer | 12/01/2016 | 96,359 |
| Cotroneo Pat | VP, Finance and CFO | 12/01/2016 | 28,975 |
| Neff Thomas B | Chief Executive Officer | 11/28/2016 | 56,716 |
| Neff Thomas B | Chief Executive Officer | 11/29/2016 | 56,716 |
| Neff Thomas B | Chief Executive Officer | 11/29/2016 | 432,031 |
| Neff Thomas B | Chief Executive Officer | 11/28/2016 | 429,763 |
| KEARNS THOMAS F JR | Director | 11/18/2016 | 52,325 |
| KEARNS THOMAS F JR | Director | 11/17/2016 | 20,125 |
| KEARNS THOMAS F JR | Director | 11/18/2016 | 292,132 |
| KEARNS THOMAS F JR | Director | 11/17/2016 | 111,028 |
| Neff Thomas B | Chief Executive Officer | 11/17/2016 | 56,716 |
| Neff Thomas B | Chief Executive Officer | 11/16/2016 | 56,716 |
| Neff Thomas B | Chief Executive Officer | 11/16/2016 | 422,582 |
| Neff Thomas B | Chief Executive Officer | 11/17/2016 | 419,936 |
| Yu K Peony | Chief Medical Officer | 11/08/2016 | 23,065 |
| Cotroneo Pat | VP, Finance and CFO | 11/04/2016 | 4,765 |
| Neff Thomas B | Chief Executive Officer | 10/31/2016 | 56,716 |
| Neff Thomas B | Chief Executive Officer | 11/01/2016 | 56,716 |
| Neff Thomas B | Chief Executive Officer | 11/01/2016 | 318,259 |
| Neff Thomas B | Chief Executive Officer | 10/31/2016 | 315,046 |
| Neff Thomas B | Chief Executive Officer | 10/19/2016 | 56,716 |
| Neff Thomas B | Chief Executive Officer | 10/18/2016 | 56,716 |
| Neff Thomas B | Chief Executive Officer | 10/19/2016 | 331,866 |
| Neff Thomas B | Chief Executive Officer | 10/18/2016 | 339,048 |
| Neff Thomas B | Chief Executive Officer | 10/04/2016 | 56,716 |
| Neff Thomas B | Chief Executive Officer | 10/03/2016 | 56,716 |
| Neff Thomas B | Chief Executive Officer | 10/03/2016 | 388,374 |
| Neff Thomas B | Chief Executive Officer | 10/04/2016 | 390,642 |
| Neff Thomas B | Chief Executive Officer | 09/20/2016 | 56,716 |
| Neff Thomas B | Chief Executive Officer | 09/21/2016 | 56,716 |
| Neff Thomas B | Chief Executive Officer | 09/21/2016 | 406,706 |
| Neff Thomas B | Chief Executive Officer | 09/20/2016 | 411,998 |
| Yu K Peony | Chief Medical Officer | 09/14/2016 | 43,758 |
| Cotroneo Pat | VP, Finance and CFO | 09/12/2016 | 42,726 |
| Neff Thomas B | Chief Executive Officer | 09/09/2016 | 56,716 |
| Neff Thomas B | Chief Executive Officer | 09/08/2016 | 56,716 |
| Neff Thomas B | Chief Executive Officer | 09/09/2016 | 355,868 |
| Neff Thomas B | Chief Executive Officer | 09/08/2016 | 361,727 |
| Neff Thomas B | Chief Executive Officer | 09/01/2016 | 81,243 |
| Yu K Peony | Chief Medical Officer | 09/01/2016 | 24,435 |
| Cotroneo Pat | VP, Finance and CFO | 09/01/2016 | 24,435 |
| Neff Thomas B | Chief Executive Officer | 08/25/2016 | 56,716 |
| Neff Thomas B | Chief Executive Officer | 08/26/2016 | 56,716 |
| Neff Thomas B | Chief Executive Officer | 08/26/2016 | 336,591 |
| Neff Thomas B | Chief Executive Officer | 08/25/2016 | 336,114 |
| Neff Thomas B | Chief Executive Officer | 07/27/2016 | 56,716 |
| Neff Thomas B | Chief Executive Officer | 07/26/2016 | 56,716 |
| Neff Thomas B | Chief Executive Officer | 07/27/2016 | 347,885 |
| Neff Thomas B | Chief Executive Officer | 07/26/2016 | 346,663 |
| Neff Thomas B | Chief Executive Officer | 07/13/2016 | 231,984 |
| Neff Thomas B | Chief Executive Officer | 07/12/2016 | 240,435 |
| Neff Thomas B | Chief Executive Officer | 06/29/2016 | 218,295 |
| Neff Thomas B | Chief Executive Officer | 06/28/2016 | 214,279 |
| Neff Thomas B | Chief Executive Officer | 06/15/2016 | 222,615 |
| Neff Thomas B | Chief Executive Officer | 06/14/2016 | 222,345 |
| Cotroneo Pat | VP, Finance and CFO | 06/15/2016 | 29,616 |
| Yu K Peony | Chief Medical Officer | 06/10/2016 | 42,098 |
| Yu K Peony | Chief Medical Officer | 06/01/2016 | 26,635 |
| Neff Thomas B | Chief Executive Officer | 06/01/2016 | 88,575 |
| Neff Thomas B | Chief Executive Officer | 06/03/2016 | 253,935 |
| Neff Thomas B | Chief Executive Officer | 06/02/2016 | 258,660 |
| Cotroneo Pat | VP, Finance and CFO | 06/01/2016 | 36,987 |
| Neff Thomas B | Chief Executive Officer | 05/19/2016 | 236,044 |
| Neff Thomas B | Chief Executive Officer | 05/20/2016 | 241,380 |
| Yu K Peony | Chief Medical Officer | 05/16/2016 | 107,483 |
| Cotroneo Pat | VP, Finance and CFO | 05/16/2016 | 107,483 |
| Neff Thomas B | Chief Executive Officer | 05/03/2016 | 237,735 |
| Neff Thomas B | Chief Executive Officer | 05/02/2016 | 242,325 |
| Neff Thomas B | Chief Executive Officer | 04/20/2016 | 266,625 |
| Neff Thomas B | Chief Executive Officer | 04/19/2016 | 272,835 |
| Neff Thomas B | Chief Executive Officer | 04/05/2016 | 282,493 |
| Neff Thomas B | Chief Executive Officer | 04/04/2016 | 287,550 |
| VALONE FRANK H MD | Chief Medical Officer | 04/01/2016 | 42,194 |
| VALONE FRANK H MD | Chief Medical Officer | 04/01/2016 | 226,941 |
| Neff Thomas B | Chief Executive Officer | 03/22/2016 | 254,745 |
| Neff Thomas B | Chief Executive Officer | 03/21/2016 | 251,127 |
| Tamura Toshinari | Director | 03/16/2016 | 126,000 |
| Neff Thomas B | Chief Executive Officer | 03/08/2016 | 258,144 |
| Neff Thomas B | Chief Executive Officer | 03/07/2016 | 271,469 |
| Yu K Peony | VP, Clinical Development | 03/03/2016 | 68,698 |
| VALONE FRANK H MD | Chief Medical Officer | 03/03/2016 | 73,597 |
| Neff Thomas B | Chief Executive Officer | 03/03/2016 | 160,559 |
| Cotroneo Pat | VP, Finance and CFO | 03/03/2016 | 68,698 |
| VALONE FRANK H MD | Chief Medical Officer | 03/01/2016 | 38,895 |
| VALONE FRANK H MD | Chief Medical Officer | 03/01/2016 | 181,040 |
| Neff Thomas B | Chief Executive Officer | 02/23/2016 | 248,400 |
| Neff Thomas B | Chief Executive Officer | 02/22/2016 | 267,450 |
| VALONE FRANK H MD | Chief Medical Officer | 02/16/2016 | 36,130 |
| VALONE FRANK H MD | Chief Medical Officer | 02/16/2016 | 197,943 |
| Neff Thomas B | Chief Executive Officer | 02/09/2016 | 204,380 |
| Neff Thomas B | Chief Executive Officer | 02/10/2016 | 208,980 |
| Yu K Peony | VP, Clinical Development | 02/05/2016 | 47,775 |
| Cotroneo Pat | VP, Finance and CFO | 02/05/2016 | 10,518 |
| Neff Thomas B | Chief Executive Officer | 01/29/2016 | 264,743 |
| Neff Thomas B | Chief Executive Officer | 01/28/2016 | 259,272 |
| Cotroneo Pat | VP, Finance and CFO | 01/21/2016 | 11,600 |
| KEARNS THOMAS F JR | Director | 01/21/2016 | 34,710 |
| VALONE FRANK H MD | Chief Medical Officer | 01/22/2016 | 29,000 |
| Neff Thomas B | Chief Executive Officer | 01/14/2016 | 316,061 |
| Neff Thomas B | Chief Executive Officer | 01/13/2016 | 323,622 |
| Routti Jorma | Director | 12/28/2015 | 64,300 |
| KEARNS THOMAS F JR | Director | 12/24/2015 | 120,159 |
| KEARNS THOMAS F JR | Director | 12/23/2015 | 120,666 |
| Neff Thomas B | Chief Executive Officer | 12/23/2015 | 417,555 |
| Neff Thomas B | Chief Executive Officer | 12/22/2015 | 395,148 |
| Cotroneo Pat | VP, Finance and CFO | 12/15/2015 | 24,231 |
| Yu K Peony | VP, Clinical Development | 12/10/2015 | 31,653 |
| Neff Thomas B | Chief Executive Officer | 12/11/2015 | 394,502 |
| Neff Thomas B | Chief Executive Officer | 12/10/2015 | 404,313 |
| MADERO MIGUEL | Director | 12/08/2015 | 627,240 |
| MADERO MIGUEL | Director | 12/08/2015 | 1,231,369 |
| Rosenkranz Roberto Pedro | Director | 12/04/2015 | 29,450 |
| Yu K Peony | VP, Clinical Development | 12/01/2015 | 19,631 |
| VALONE FRANK H MD | Chief Medical Officer | 12/01/2015 | 21,036 |
| Neff Thomas B | Chief Executive Officer | 12/01/2015 | 68,186 |
| Cotroneo Pat | VP, Finance and CFO | 12/01/2015 | 27,280 |
| Cotroneo Pat | VP, Finance and CFO | 12/03/2015 | 3,770 |
| Yu K Peony | VP, Clinical Development | 11/30/2015 | 139,680 |
| Yu K Peony | VP, Clinical Development | 11/25/2015 | 10,320 |
| Cotroneo Pat | VP, Finance and CFO | 11/25/2015 | 11,750 |
| Cotroneo Pat | VP, Finance and CFO | 11/25/2015 | 150,000 |
| Neff Thomas B | Chief Executive Officer | 11/24/2015 | 391,215 |
| Neff Thomas B | Chief Executive Officer | 11/23/2015 | 377,910 |
| KEARNS THOMAS F JR | Director | 11/23/2015 | 109,278 |
| KEARNS THOMAS F JR | Director | 11/24/2015 | 113,111 |
| Yu K Peony | VP, Clinical Development | 11/17/2015 | 140,000 |
| VALONE FRANK H MD | Chief Medical Officer | 11/13/2015 | 29,000 |
| Yu K Peony | VP, Clinical Development | 11/09/2015 | 62,500 |
| Yu K Peony | VP, Clinical Development | 11/10/2015 | 65,575 |
| VALONE FRANK H MD | Chief Medical Officer | 11/02/2015 | 29,000 |
| VALONE FRANK H MD | Chief Medical Officer | 11/02/2015 | 231,793 |
| Neff Thomas B | Chief Executive Officer | 10/30/2015 | 324,778 |
| Neff Thomas B | Chief Executive Officer | 10/29/2015 | 324,776 |
| KEARNS THOMAS F JR | Director | 10/21/2015 | 91,007 |
| KEARNS THOMAS F JR | Director | 10/20/2015 | 94,896 |
| VALONE FRANK H MD | Chief Medical Officer | 10/19/2015 | 23,500 |
| VALONE FRANK H MD | Chief Medical Officer | 10/19/2015 | 230,000 |
| Yu K Peony | VP, Clinical Development | 10/19/2015 | 120,000 |
| Neff Thomas B | Chief Executive Officer | 10/16/2015 | 298,074 |
| Neff Thomas B | Chief Executive Officer | 10/15/2015 | 292,075 |
| Yu K Peony | VP, Clinical Development | 10/15/2015 | 51,250 |
| Yu K Peony | VP, Clinical Development | 10/16/2015 | 56,050 |
| Neff Thomas B | Chief Executive Officer | 10/02/2015 | 294,696 |
| Neff Thomas B | Chief Executive Officer | 10/01/2015 | 288,360 |
| VALONE FRANK H MD | Chief Medical Officer | 10/01/2015 | 23,500 |
| VALONE FRANK H MD | Chief Medical Officer | 10/01/2015 | 213,782 |
| Neff Thomas B | Chief Executive Officer | 09/17/2015 | 26,695 |
| Neff Thomas B | Chief Executive Officer | 09/18/2015 | 27,460 |
| Neff Thomas B | Chief Executive Officer | 09/17/2015 | 391,996 |
| Neff Thomas B | Chief Executive Officer | 09/18/2015 | 393,695 |
| RIGGS RORY B | Director | 09/14/2015 | 704,737 |
| RIGGS RORY B | Director | 09/11/2015 | 675,927 |
| MADERO MIGUEL | Director | 09/11/2015 | 569,796 |
| Cotroneo Pat | VP, Finance and CFO | 09/11/2015 | 3,886 |
| Cotroneo Pat | VP, Finance and CFO | 09/15/2015 | 30,549 |
| Yu K Peony | VP, Clinical Development | 09/10/2015 | 30,430 |
| Cotroneo Pat | VP, Finance and CFO | 09/10/2015 | 11,750 |
| Cotroneo Pat | VP, Finance and CFO | 09/08/2015 | 7,876 |
| Cotroneo Pat | VP, Finance and CFO | 09/10/2015 | 140,000 |
| Cotroneo Pat | VP, Finance and CFO | 09/08/2015 | 65,000 |
| Neff Thomas B | Chief Executive Officer | 09/04/2015 | 22,252 |
| Neff Thomas B | Chief Executive Officer | 09/04/2015 | 308,884 |
| Yu K Peony | VP, Clinical Development | 09/01/2015 | 15,006 |
| VALONE FRANK H MD | Chief Medical Officer | 09/01/2015 | 16,079 |
| VALONE FRANK H MD | Chief Medical Officer | 09/01/2015 | 23,500 |
| VALONE FRANK H MD | Chief Medical Officer | 09/01/2015 | 235,782 |
| Neff Thomas B | Chief Executive Officer | 09/01/2015 | 52,121 |
| Neff Thomas B | Chief Executive Officer | 09/03/2015 | 22,252 |
| Neff Thomas B | Chief Executive Officer | 09/03/2015 | 309,360 |
| Cotroneo Pat | VP, Finance and CFO | 09/01/2015 | 15,006 |
| MADERO MIGUEL | Director | 08/17/2015 | 48,300 |
| Neff Thomas B | Chief Executive Officer | 08/06/2015 | 22,252 |
| Neff Thomas B | Chief Executive Officer | 08/05/2015 | 22,252 |
| Neff Thomas B | Chief Executive Officer | 08/05/2015 | 321,561 |
| Neff Thomas B | Chief Executive Officer | 08/06/2015 | 308,075 |
| VALONE FRANK H MD | Chief Medical Officer | 08/03/2015 | 23,500 |
| VALONE FRANK H MD | Chief Medical Officer | 08/03/2015 | 233,731 |
| Cotroneo Pat | VP, Finance and CFO | 07/27/2015 | 4,060 |
| Neff Thomas B | Chief Executive Officer | 07/22/2015 | 22,252 |
| Neff Thomas B | Chief Executive Officer | 07/23/2015 | 22,252 |
| Neff Thomas B | Chief Executive Officer | 07/22/2015 | 332,370 |
| Neff Thomas B | Chief Executive Officer | 07/23/2015 | 334,800 |
| VALONE FRANK H MD | Chief Medical Officer | 07/20/2015 | 2,350 |
| VALONE FRANK H MD | Chief Medical Officer | 07/20/2015 | 23,702 |
| Cotroneo Pat | VP, Finance and CFO | 07/20/2015 | 5,875 |
| Cotroneo Pat | VP, Finance and CFO | 07/20/2015 | 60,000 |
| Cotroneo Pat | VP, Finance and CFO | 07/17/2015 | 125,001 |
| Neff Thomas B | Chief Executive Officer | 07/09/2015 | 22,252 |
| Neff Thomas B | Chief Executive Officer | 07/08/2015 | 22,252 |
| Neff Thomas B | Chief Executive Officer | 07/09/2015 | 298,755 |
| Neff Thomas B | Chief Executive Officer | 07/08/2015 | 298,080 |
| Yu K Peony | VP, Clinical Development | 07/06/2015 | 122,097 |
| Neff Thomas B | Chief Executive Officer | 06/24/2015 | 22,252 |
| Neff Thomas B | Chief Executive Officer | 06/25/2015 | 22,252 |
| Neff Thomas B | Chief Executive Officer | 06/25/2015 | 317,520 |
| Neff Thomas B | Chief Executive Officer | 06/24/2015 | 318,804 |
| Cotroneo Pat | VP, Finance and CFO | 06/12/2015 | 34,800 |
| Neff Thomas B | Chief Executive Officer | 06/01/2015 | 39,935 |
| Yu K Peony | VP, Clinical Development | 06/01/2015 | 11,498 |
| VALONE FRANK H MD | Chief Medical Officer | 06/01/2015 | 12,320 |
| Controneo Pat | VP, Finance and CFO | 06/01/2015 | 11,498 |
| STERN JULIAN N | Director | 05/20/2015 | 324,000 |
| Neff Thomas B | Chief Executive Officer | 05/14/2015 | 199,718 |
| VALONE FRANK H MD | Chief Medical Officer | 05/14/2015 | 62,159 |
| Yu K Peony | VP, Clinical Development | 05/14/2015 | 58,010 |
| Yu K Peony | VP, Clinical Development | 05/15/2015 | 25,600 |
| Controneo Pat | VP, Finance and CFO | 05/14/2015 | 58,010 |
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FUNDS WITH A POSITION IN FIBROGEN INC
| Fund | # Shares Owned | % of Portfolio | % Change | Investing Style |
|---|---|---|---|---|
| BLACKROCK INC. | 6,967,918 | 0.00038% | -3.29% | Other |
| GEODE CAPITAL MANAGEMENT, LLC | 2,074,666 | 0.00045% | 2.79% | Other |
| D. E. SHAW & CO., INC. | 99,975 | 0.0002% | -94.67% | Other |
| AQR CAPITAL MANAGEMENT LLC | 551,280 | 0.00221% | -52.69% | Other |
| RENAISSANCE TECHNOLOGIES LLC | 166,500 | 0.00061% | -75.64% | Other |
| TUDOR INVESTMENT CORP ET AL | 48,199 | 0.00034% | Exited | Event Driven, Other |
| ALPINE GLOBAL MANAGEMENT, LLC | 10,752 | 0.00635% | New | Event Driven |
CHANGE IN SHARES OUTSTANDING FOR FIBROGEN INC
STOCK BUYBACKS FOR FIBROGEN INC
Period of Report
Previous Period
% Change in Shares
10-K/10-Q Filings
Quarter
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Period of Report: 03/31/2024
10-K/10-Q Filings: View
Previous Period
% Change in Shares
Quarter
12/31/2023
0.48%
1Q
09/30/2023
0.75%
2Q
06/30/2023
1.28%
3Q
03/31/2023
4.53%
4Q
12/31/2022
5.26%
5Q
09/30/2022
5.56%
6Q
06/30/2022
5.89%
7Q
03/31/2022
6.38%
8Q
12/31/2021
6.69%
9Q
09/30/2021
6.65%
10Q
06/30/2021
7.27%
11Q
03/31/2021
7.96%
12Q
12/31/2020
8.56%
13Q
09/30/2020
5.66%
14Q
06/30/2020
10.65%
15Q
03/31/2020
12.20%
16Q
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BUYBACK ANNOUNCEMENT(S) FOR FIBROGEN INC
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