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INSIDER TRANSACTIONS FOR
| Owner | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| BAKER BROS. ADVISORS LP | Director | Aug 16, 2023 | Buy | $0.68 | 229,600 | 156,254 | 5,458,724 | Aug 17, 2023, 05:08 PM |
| BAKER BROS. ADVISORS LP | Director | Aug 15, 2023 | Buy | $0.63 | 1,888,800 | 1,191,616 | 5,246,614 | Aug 17, 2023, 05:08 PM |
| BAKER BROS. ADVISORS LP | Director | Aug 17, 2023 | Buy | $0.69 | 166,942 | 115,617 | 5,612,949 | Aug 17, 2023, 05:08 PM |
| Smith Sean Michael | Interim CFO, Prin Acct Off | Aug 11, 2023 | Sale | $0.62 | 1,323 | 818 | 21,637 | Aug 14, 2023, 04:06 PM |
| Patel Priti | Former Chief Medical Officer | Apr 03, 2023 | Sale | $0.69 | 3,769 | 2,608 | 37,313 | Apr 04, 2023, 08:51 PM |
| Smith Sean Michael | Principal Accounting Officer | Feb 02, 2023 | Sale | $0.60 | 3,316 | 1,980 | 15,960 | Feb 03, 2023, 04:33 PM |
| Patel Priti | Chief Medical Officer | Feb 02, 2023 | Sale | $0.60 | 14,380 | 8,588 | 31,082 | Feb 03, 2023, 04:32 PM |
| Smith Sean Michael | Principal Accounting Officer | Aug 10, 2022 | Sale | $0.99 | 1,655 | 1,641 | 6,776 | Aug 12, 2022, 05:24 PM |
| Patel Priti | Chief Medical Officer | May 02, 2022 | Sale | $1.22 | 5,538 | 6,749 | 6,462 | May 03, 2022, 07:16 PM |
| DRACHMAN JONATHAN G | President and CEO | Aug 25, 2021 | Buy | $6.45 | 50,000 | 322,450 | 25,000 | Aug 26, 2021, 07:08 PM |
| DRACHMAN JONATHAN G | President and CEO | Aug 24, 2021 | Buy | $6.11 | 100,000 | 611,100 | 2,348,686 | Aug 26, 2021, 07:08 PM |
| Walkey Carl | Senior Vice President | Jun 16, 2021 | Sale | $10.19 | 600 | 6,114 | 1,352,489 | Jun 17, 2021, 09:46 PM |
| Walkey Carl | Senior Vice President | Jun 08, 2021 | Sale | $11.00 | 600 | 6,600 | 1,353,739 | Jun 09, 2021, 05:22 PM |
| Walkey Carl | Senior Vice President | May 26, 2021 | Sale | $10.00 | 600 | 6,000 | 1,354,939 | May 26, 2021, 07:37 PM |
| Walkey Carl | Senior Vice President | May 19, 2021 | Sale | $10.63 | 600 | 6,378 | 1,355,539 | May 21, 2021, 05:24 PM |
| Walkey Carl | Senior Vice President | Apr 26, 2021 | Sale | $13.00 | 600 | 7,800 | 1,359,562 | Apr 27, 2021, 07:59 PM |
| Walkey Carl | Senior Vice President | Apr 21, 2021 | Sale | $11.98 | 1,800 | 21,564 | 1,360,162 | Apr 22, 2021, 05:11 PM |
| Walkey Carl | Senior Vice President | Apr 14, 2021 | Sale | $12.22 | 1,800 | 21,996 | 1,361,962 | Apr 16, 2021, 07:08 PM |
| Walkey Carl | Senior Vice President | Apr 07, 2021 | Sale | $12.02 | 1,800 | 21,636 | 1,363,762 | Apr 08, 2021, 07:06 PM |
| Walkey Carl | Senior Vice President | Mar 31, 2021 | Sale | $11.96 | 1,800 | 21,528 | 1,366,162 | Apr 02, 2021, 05:21 PM |
| Walkey Carl | Senior Vice President | Mar 24, 2021 | Sale | $11.95 | 1,800 | 21,516 | 1,367,962 | Mar 24, 2021, 06:48 PM |
| Walkey Carl | Senior Vice President | Mar 22, 2021 | Sale | $12.00 | 600 | 7,200 | 1,369,762 | Mar 24, 2021, 06:48 PM |
| Walkey Carl | Senior Vice President | Mar 17, 2021 | Sale | $11.36 | 1,200 | 13,632 | 1,370,362 | Mar 18, 2021, 08:45 PM |
| Ho Robert | Chief Financial Officer | Mar 17, 2021 | Sale | $11.01 | 6,497 | 71,556 | 21,503 | Mar 18, 2021, 08:44 PM |
| Walkey Carl | Senior Vice President | Mar 10, 2021 | Sale | $11.97 | 1,800 | 21,540 | 1,371,562 | Mar 11, 2021, 04:14 PM |
| Walkey Carl | Senior Vice President | Mar 03, 2021 | Sale | $11.87 | 1,800 | 21,360 | 1,373,362 | Mar 04, 2021, 06:52 PM |
| Walkey Carl | Senior Vice President | Feb 25, 2021 | Sale | $13.00 | 600 | 7,800 | 1,375,162 | Feb 25, 2021, 08:17 PM |
| Walkey Carl | Senior Vice President | Feb 24, 2021 | Sale | $12.14 | 1,800 | 21,852 | 1,375,762 | Feb 25, 2021, 08:17 PM |
| Walkey Carl | Senior Vice President | Feb 17, 2021 | Sale | $12.70 | 2,400 | 30,480 | 1,377,562 | Feb 18, 2021, 04:20 PM |
| Walkey Carl | Senior Vice President | Feb 10, 2021 | Sale | $14.20 | 3,000 | 42,600 | 1,379,962 | Feb 12, 2021, 04:23 PM |
| Walkey Carl | Senior Vice President | Feb 05, 2021 | Sale | $14.00 | 600 | 8,400 | 1,382,962 | Feb 09, 2021, 04:41 PM |
| Walkey Carl | Senior Vice President | Feb 03, 2021 | Sale | $13.23 | 2,400 | 31,752 | 1,383,562 | Feb 05, 2021, 04:51 PM |
| BAKER BROS. ADVISORS LP | Director | Jul 07, 2020 | Buy | $15.25 | 424,000 | 6,466,000 | 3,501,691 | Dec 23, 2020, 07:31 PM |
| Redmile Group, LLC | 10% Owner | Mar 27, 2020 | Buy | $9.21 | 50,000 | 460,395 | 3,916,579 | Apr 06, 2020, 07:04 PM |
| Redmile Group, LLC | 10% Owner | Apr 02, 2020 | Buy | $11.37 | 39,300 | 446,958 | 4,051,045 | Apr 06, 2020, 07:04 PM |
| Redmile Group, LLC | 10% Owner | Apr 01, 2020 | Buy | $11.10 | 42,500 | 471,630 | 4,021,579 | Apr 06, 2020, 07:04 PM |
| Redmile Group, LLC | 10% Owner | Mar 31, 2020 | Buy | $10.31 | 30,000 | 309,389 | 3,979,079 | Apr 06, 2020, 07:04 PM |
| Redmile Group, LLC | 10% Owner | Mar 30, 2020 | Buy | $9.94 | 32,500 | 322,910 | 3,949,079 | Apr 06, 2020, 07:04 PM |
| Redmile Group, LLC | 10% Owner | Apr 02, 2020 | Sale | $11.31 | 9,834 | 111,214 | 4,041,311 | Apr 06, 2020, 07:04 PM |
| Redmile Group, LLC | 10% Owner | Apr 01, 2020 | Sale | $11.08 | 9,834 | 108,940 | 4,011,945 | Apr 06, 2020, 07:04 PM |
| DRACHMAN JONATHAN G | President and CEO | Dec 20, 2019 | Buy | $8.40 | 119,047 | 999,995 | 2,198,686 | Dec 20, 2019, 06:53 PM |
| BAKER BROS. ADVISORS LP | Director | Dec 20, 2019 | Buy | $8.40 | 3,017,542 | 25,347,352 | 12,872,664 | Dec 20, 2019, 05:16 PM |
| DRACHMAN JONATHAN G | See Remarks | Sep 11, 2019 | Buy | $3.30 | 136,436 | 449,898 | 584,428 | Sep 11, 2019, 05:39 PM |
| DRACHMAN JONATHAN G | See Remarks | Sep 10, 2019 | Buy | $3.08 | 36,742 | 113,290 | 447,992 | Sep 11, 2019, 05:39 PM |
| DRACHMAN JONATHAN G | See Remarks | Sep 09, 2019 | Buy | $2.85 | 76,822 | 218,559 | 411,250 | Sep 11, 2019, 05:39 PM |
| BAKER BROS. ADVISORS LP | Director | Aug 06, 2019 | Buy | $2.85 | 81,800 | 232,731 | 9,839,472 | Aug 08, 2019, 05:00 PM |
| BAKER BROS. ADVISORS LP | Director | Aug 07, 2019 | Buy | $3.05 | 289,725 | 882,884 | 10,105,159 | Aug 08, 2019, 05:00 PM |
| LEVITT DANIEL J | Director | May 14, 2018 | Option Exercise | $10.56 | 3,906 | 41,247 | 3,906 | May 16, 2018, 07:45 PM |
| LEVITT DANIEL J | Director | May 14, 2018 | Sale | $12.67 | 3,906 | 49,489 | 0 | May 16, 2018, 07:45 PM |
| MacKenzie Lloyd | Chief Operating Officer | Mar 15, 2018 | Option Exercise | $10.56 | 1,302 | 13,749 | 1,302 | Mar 19, 2018, 05:58 PM |
| MacKenzie Lloyd | Chief Operating Officer | Mar 15, 2018 | Sale | $14.63 | 1,302 | 19,049 | 0 | Mar 19, 2018, 05:58 PM |
| Main David | President and CEO | Jun 02, 2017 | Option Exercise | $9.60 | 6,000 | 57,600 | 77,530 | Jun 05, 2017, 07:00 PM |
| Main David | President and CEO | Jun 01, 2017 | Option Exercise | $9.60 | 6,000 | 57,600 | 77,530 | Jun 05, 2017, 07:00 PM |
| Main David | President and CEO | Jun 05, 2017 | Option Exercise | $9.60 | 3,625 | 34,800 | 75,155 | Jun 05, 2017, 07:00 PM |
| Main David | President and CEO | Jun 02, 2017 | Sale | $13.59 | 6,000 | 81,560 | 71,530 | Jun 05, 2017, 07:00 PM |
| Main David | President and CEO | Jun 01, 2017 | Sale | $13.00 | 6,000 | 77,988 | 71,530 | Jun 05, 2017, 07:00 PM |
| Main David | President and CEO | Jun 05, 2017 | Sale | $13.16 | 3,625 | 47,696 | 71,530 | Jun 05, 2017, 07:00 PM |
| BAKER BROS. ADVISORS LP | 10% Owner | Jan 09, 2017 | Buy | $17.18 | 398,062 | 6,836,813 | 9,764,459 | Jan 09, 2017, 06:46 PM |
| BAKER BROS. ADVISORS LP | 10% Owner | Sep 20, 2016 | Buy | $12.25 | 2,783,605 | 34,110,452 | 9,404,467 | Sep 21, 2016, 04:28 PM |
| BAKER BROS. ADVISORS LP | 10% Owner | Mar 16, 2016 | Buy | $8.00 | 361,755 | 2,893,570 | 6,928,119 | Mar 16, 2016, 06:56 PM |
| BAKER BROS. ADVISORS LP | 10% Owner | Mar 15, 2016 | Buy | $7.98 | 106,538 | 850,484 | 6,601,891 | Mar 16, 2016, 06:56 PM |
| BAKER BROS. ADVISORS LP | 10% Owner | Mar 15, 2016 | Buy | $7.88 | 3,374 | 26,582 | 781,421 | Mar 16, 2016, 06:56 PM |
| BAKER BROS. ADVISORS LP | 10% Owner | Jan 22, 2016 | Buy | $10.78 | 1,887 | 20,345 | 765,980 | Jan 26, 2016, 06:53 PM |
| BAKER BROS. ADVISORS LP | 10% Owner | Jan 26, 2016 | Buy | $10.81 | 77,639 | 839,524 | 6,502,773 | Jan 26, 2016, 06:53 PM |
| BAKER BROS. ADVISORS LP | 10% Owner | Jan 25, 2016 | Buy | $11.11 | 10,945 | 121,576 | 6,432,847 | Jan 26, 2016, 06:53 PM |
| BAKER BROS. ADVISORS LP | 10% Owner | Jan 22, 2016 | Buy | $10.72 | 50,315 | 539,465 | 6,422,989 | Jan 26, 2016, 06:53 PM |
| BAKER BROS. ADVISORS LP | 10% Owner | Jan 20, 2016 | Buy | $9.48 | 112,034 | 1,062,538 | 6,375,941 | Jan 20, 2016, 07:12 PM |
| BAKER BROS. ADVISORS LP | 10% Owner | Jan 19, 2016 | Buy | $9.11 | 73,016 | 665,474 | 6,274,969 | Jan 20, 2016, 07:12 PM |
| BAKER BROS. ADVISORS LP | 10% Owner | Jan 19, 2016 | Buy | $9.08 | 5,029 | 45,642 | 750,354 | Jan 20, 2016, 07:12 PM |
| BAKER BROS. ADVISORS LP | 10% Owner | Jan 15, 2016 | Buy | $8.47 | 84,670 | 717,201 | 6,204,630 | Jan 15, 2016, 05:37 PM |
| BAKER BROS. ADVISORS LP | 10% Owner | Jan 14, 2016 | Buy | $8.13 | 107,983 | 878,410 | 6,128,358 | Jan 15, 2016, 05:37 PM |
| BAKER BROS. ADVISORS LP | 10% Owner | Jan 14, 2016 | Buy | $8.17 | 9,970 | 81,472 | 735,198 | Jan 15, 2016, 05:37 PM |
| BAKER BROS. ADVISORS LP | 10% Owner | Jan 15, 2016 | Buy | $8.47 | 84,670 | 717,201 | 6,204,630 | Jan 15, 2016, 05:13 PM |
| BAKER BROS. ADVISORS LP | 10% Owner | Jan 14, 2016 | Buy | $8.13 | 107,983 | 878,410 | 6,128,358 | Jan 15, 2016, 05:13 PM |
| BAKER BROS. ADVISORS LP | 10% Owner | Jan 14, 2016 | Buy | $8.17 | 9,970 | 81,472 | 735,198 | Jan 15, 2016, 05:13 PM |
| BAKER BROS. ADVISORS LP | 10% Owner | Sep 10, 2015 | Buy | $15.50 | 2,213,469 | 34,308,770 | 6,022,104 | Sep 11, 2015, 04:11 PM |
| BAKER BROS. ADVISORS LP | 10% Owner | Sep 10, 2015 | Buy | $15.50 | 266,563 | 4,131,727 | 725,228 | Sep 11, 2015, 04:11 PM |
| Mitchell David Chilton | VP Global Regulatory & Quality | Aug 24, 2015 | Buy | $17.81 | 3,575 | 63,671 | 3,575 | Aug 26, 2015, 04:48 PM |
| MacKenzie Lloyd | VP Technical Operations | Aug 12, 2015 | Option Exercise | $5.76 | 35,887 | 206,709 | 35,887 | Aug 14, 2015, 08:39 PM |
| MacKenzie Lloyd | VP Technical Operations | Aug 12, 2015 | Sale | $18.67 | 35,887 | 670,010 | 0 | Aug 14, 2015, 08:39 PM |
| Alam Kamran | CFO, Vice President Finance | Aug 12, 2015 | Option Exercise | $5.76 | 29,079 | 167,495 | 29,079 | Aug 14, 2015, 08:36 PM |
| Alam Kamran | CFO, Vice President Finance | Aug 12, 2015 | Sale | $18.67 | 29,079 | 542,905 | 0 | Aug 14, 2015, 08:36 PM |
| Mitchell David Chilton | VP Global Regulatory & Quality | Aug 11, 2015 | Buy | $24.36 | 1,600 | 38,976 | 1,600 | Aug 13, 2015, 08:20 PM |
| PFIZER INC | 10% Owner | Aug 10, 2015 | Sale | $26.47 | 259,927 | 6,880,295 | 1,235,312 | Aug 12, 2015, 04:30 PM |
| JOHNSON & JOHNSON | 10% Owner | Aug 10, 2015 | Sale | $31.66 | 231,455 | 7,327,865 | 1,383,366 | Aug 12, 2015, 12:24 PM |
| JOHNSON & JOHNSON | 10% Owner | Aug 11, 2015 | Sale | $20.74 | 1,283,366 | 26,617,011 | 100,000 | Aug 12, 2015, 12:24 PM |
| JOHNSON & JOHNSON | 10% Owner | Mar 12, 2014 | Buy | $11.00 | 272,727 | 2,999,997 | 1,664,821 | Feb 03, 2015, 12:05 PM |
| JOHNSON & JOHNSON | 10% Owner | Dec 17, 2014 | Sale | $7.58 | 1,593 | 12,075 | 1,342,094 | Dec 18, 2014, 10:43 AM |
| JOHNSON & JOHNSON | 10% Owner | Dec 16, 2014 | Sale | $7.63 | 6,507 | 49,648 | 1,343,687 | Dec 18, 2014, 10:43 AM |
| JOHNSON & JOHNSON | 10% Owner | Dec 12, 2014 | Sale | $7.51 | 3,645 | 27,374 | 1,350,194 | Dec 15, 2014, 08:48 PM |
| JOHNSON & JOHNSON | 10% Owner | Dec 11, 2014 | Sale | $7.50 | 1,355 | 10,163 | 1,353,839 | Dec 15, 2014, 08:48 PM |
| JOHNSON & JOHNSON | 10% Owner | Dec 10, 2014 | Sale | $7.70 | 1,300 | 10,010 | 1,355,194 | Dec 10, 2014, 09:13 PM |
| JOHNSON & JOHNSON | 10% Owner | Dec 09, 2014 | Sale | $7.73 | 5,000 | 38,650 | 1,356,494 | Dec 10, 2014, 09:13 PM |
| JOHNSON & JOHNSON | 10% Owner | Dec 08, 2014 | Sale | $7.69 | 2,000 | 15,380 | 1,361,494 | Dec 10, 2014, 09:13 PM |
| JOHNSON & JOHNSON | 10% Owner | Dec 05, 2014 | Sale | $7.78 | 4,200 | 32,676 | 1,363,494 | Dec 05, 2014, 06:57 PM |
| JOHNSON & JOHNSON | 10% Owner | Dec 04, 2014 | Sale | $7.76 | 10,073 | 78,166 | 1,367,694 | Dec 05, 2014, 06:57 PM |
| JOHNSON & JOHNSON | 10% Owner | Dec 03, 2014 | Sale | $7.75 | 1,627 | 12,609 | 1,377,767 | Dec 05, 2014, 06:57 PM |
| JOHNSON & JOHNSON | 10% Owner | Dec 01, 2014 | Sale | $7.54 | 1,200 | 9,048 | 1,379,394 | Dec 03, 2014, 02:24 PM |
| JOHNSON & JOHNSON | 10% Owner | Nov 26, 2014 | Sale | $7.60 | 500 | 3,800 | 1,380,594 | Nov 26, 2014, 04:18 PM |
| JOHNSON & JOHNSON | 10% Owner | Nov 25, 2014 | Sale | $7.80 | 1,500 | 11,700 | 1,381,094 | Nov 26, 2014, 04:18 PM |
| JOHNSON & JOHNSON | 10% Owner | Nov 24, 2014 | Sale | $8.02 | 4,000 | 32,080 | 1,382,594 | Nov 24, 2014, 05:45 PM |
| JOHNSON & JOHNSON | 10% Owner | Nov 21, 2014 | Sale | $8.25 | 2,400 | 19,800 | 1,386,594 | Nov 24, 2014, 05:45 PM |
| JOHNSON & JOHNSON | 10% Owner | Nov 20, 2014 | Sale | $8.21 | 3,100 | 25,451 | 1,388,994 | Nov 24, 2014, 05:45 PM |
| PFIZER INC | 10% Owner | Mar 12, 2014 | Buy | $11.00 | 272,727 | 2,999,997 | 1,235,330 | Mar 14, 2014, 03:27 PM |
| Main David | President and CEO | Mar 12, 2014 | Option Exercise | $11.00 | 9,459 | 104,049 | 71,530 | Mar 14, 2014, 03:21 PM |
Load More Insider Transactions
Buy
Sale
Option Exercise
| Owner | Relationship | Date | Value($) |
| BAKER BROS. ADVISORS LP | Director | 08/16/2023 | 156,254 |
| BAKER BROS. ADVISORS LP | Director | 08/15/2023 | 1,191,616 |
| BAKER BROS. ADVISORS LP | Director | 08/17/2023 | 115,617 |
| Smith Sean Michael | Interim CFO, Prin Acct Off | 08/11/2023 | 818 |
| Patel Priti | Former Chief Medical Officer | 04/03/2023 | 2,608 |
| Smith Sean Michael | Principal Accounting Officer | 02/02/2023 | 1,980 |
| Patel Priti | Chief Medical Officer | 02/02/2023 | 8,588 |
| Smith Sean Michael | Principal Accounting Officer | 08/10/2022 | 1,641 |
| Patel Priti | Chief Medical Officer | 05/02/2022 | 6,749 |
| DRACHMAN JONATHAN G | President and CEO | 08/25/2021 | 322,450 |
| DRACHMAN JONATHAN G | President and CEO | 08/24/2021 | 611,100 |
| Walkey Carl | Senior Vice President | 06/16/2021 | 6,114 |
| Walkey Carl | Senior Vice President | 06/08/2021 | 6,600 |
| Walkey Carl | Senior Vice President | 05/26/2021 | 6,000 |
| Walkey Carl | Senior Vice President | 05/19/2021 | 6,378 |
| Walkey Carl | Senior Vice President | 04/26/2021 | 7,800 |
| Walkey Carl | Senior Vice President | 04/21/2021 | 21,564 |
| Walkey Carl | Senior Vice President | 04/14/2021 | 21,996 |
| Walkey Carl | Senior Vice President | 04/07/2021 | 21,636 |
| Walkey Carl | Senior Vice President | 03/31/2021 | 21,528 |
| Walkey Carl | Senior Vice President | 03/24/2021 | 21,516 |
| Walkey Carl | Senior Vice President | 03/22/2021 | 7,200 |
| Walkey Carl | Senior Vice President | 03/17/2021 | 13,632 |
| Ho Robert | Chief Financial Officer | 03/17/2021 | 71,556 |
| Walkey Carl | Senior Vice President | 03/10/2021 | 21,540 |
| Walkey Carl | Senior Vice President | 03/03/2021 | 21,360 |
| Walkey Carl | Senior Vice President | 02/25/2021 | 7,800 |
| Walkey Carl | Senior Vice President | 02/24/2021 | 21,852 |
| Walkey Carl | Senior Vice President | 02/17/2021 | 30,480 |
| Walkey Carl | Senior Vice President | 02/10/2021 | 42,600 |
| Walkey Carl | Senior Vice President | 02/05/2021 | 8,400 |
| Walkey Carl | Senior Vice President | 02/03/2021 | 31,752 |
| BAKER BROS. ADVISORS LP | Director | 07/07/2020 | 6,466,000 |
| Redmile Group, LLC | 10% Owner | 03/27/2020 | 460,395 |
| Redmile Group, LLC | 10% Owner | 04/02/2020 | 446,958 |
| Redmile Group, LLC | 10% Owner | 04/01/2020 | 471,630 |
| Redmile Group, LLC | 10% Owner | 03/31/2020 | 309,389 |
| Redmile Group, LLC | 10% Owner | 03/30/2020 | 322,910 |
| Redmile Group, LLC | 10% Owner | 04/02/2020 | 111,214 |
| Redmile Group, LLC | 10% Owner | 04/01/2020 | 108,940 |
| DRACHMAN JONATHAN G | President and CEO | 12/20/2019 | 999,995 |
| BAKER BROS. ADVISORS LP | Director | 12/20/2019 | 25,347,352 |
| DRACHMAN JONATHAN G | See Remarks | 09/11/2019 | 449,898 |
| DRACHMAN JONATHAN G | See Remarks | 09/10/2019 | 113,290 |
| DRACHMAN JONATHAN G | See Remarks | 09/09/2019 | 218,559 |
| BAKER BROS. ADVISORS LP | Director | 08/06/2019 | 232,731 |
| BAKER BROS. ADVISORS LP | Director | 08/07/2019 | 882,884 |
| LEVITT DANIEL J | Director | 05/14/2018 | 41,247 |
| LEVITT DANIEL J | Director | 05/14/2018 | 49,489 |
| MacKenzie Lloyd | Chief Operating Officer | 03/15/2018 | 13,749 |
| MacKenzie Lloyd | Chief Operating Officer | 03/15/2018 | 19,049 |
| Main David | President and CEO | 06/02/2017 | 57,600 |
| Main David | President and CEO | 06/01/2017 | 57,600 |
| Main David | President and CEO | 06/05/2017 | 34,800 |
| Main David | President and CEO | 06/02/2017 | 81,560 |
| Main David | President and CEO | 06/01/2017 | 77,988 |
| Main David | President and CEO | 06/05/2017 | 47,696 |
| BAKER BROS. ADVISORS LP | 10% Owner | 01/09/2017 | 6,836,813 |
| BAKER BROS. ADVISORS LP | 10% Owner | 09/20/2016 | 34,110,452 |
| BAKER BROS. ADVISORS LP | 10% Owner | 03/16/2016 | 2,893,570 |
| BAKER BROS. ADVISORS LP | 10% Owner | 03/15/2016 | 850,484 |
| BAKER BROS. ADVISORS LP | 10% Owner | 03/15/2016 | 26,582 |
| BAKER BROS. ADVISORS LP | 10% Owner | 01/22/2016 | 20,345 |
| BAKER BROS. ADVISORS LP | 10% Owner | 01/26/2016 | 839,524 |
| BAKER BROS. ADVISORS LP | 10% Owner | 01/25/2016 | 121,576 |
| BAKER BROS. ADVISORS LP | 10% Owner | 01/22/2016 | 539,465 |
| BAKER BROS. ADVISORS LP | 10% Owner | 01/20/2016 | 1,062,538 |
| BAKER BROS. ADVISORS LP | 10% Owner | 01/19/2016 | 665,474 |
| BAKER BROS. ADVISORS LP | 10% Owner | 01/19/2016 | 45,642 |
| BAKER BROS. ADVISORS LP | 10% Owner | 01/15/2016 | 717,201 |
| BAKER BROS. ADVISORS LP | 10% Owner | 01/14/2016 | 878,410 |
| BAKER BROS. ADVISORS LP | 10% Owner | 01/14/2016 | 81,472 |
| BAKER BROS. ADVISORS LP | 10% Owner | 01/15/2016 | 717,201 |
| BAKER BROS. ADVISORS LP | 10% Owner | 01/14/2016 | 878,410 |
| BAKER BROS. ADVISORS LP | 10% Owner | 01/14/2016 | 81,472 |
| BAKER BROS. ADVISORS LP | 10% Owner | 09/10/2015 | 34,308,770 |
| BAKER BROS. ADVISORS LP | 10% Owner | 09/10/2015 | 4,131,727 |
| Mitchell David Chilton | VP Global Regulatory & Quality | 08/24/2015 | 63,671 |
| MacKenzie Lloyd | VP Technical Operations | 08/12/2015 | 206,709 |
| MacKenzie Lloyd | VP Technical Operations | 08/12/2015 | 670,010 |
| Alam Kamran | CFO, Vice President Finance | 08/12/2015 | 167,495 |
| Alam Kamran | CFO, Vice President Finance | 08/12/2015 | 542,905 |
| Mitchell David Chilton | VP Global Regulatory & Quality | 08/11/2015 | 38,976 |
| PFIZER INC | 10% Owner | 08/10/2015 | 6,880,295 |
| JOHNSON & JOHNSON | 10% Owner | 08/10/2015 | 7,327,865 |
| JOHNSON & JOHNSON | 10% Owner | 08/11/2015 | 26,617,011 |
| JOHNSON & JOHNSON | 10% Owner | 03/12/2014 | 2,999,997 |
| JOHNSON & JOHNSON | 10% Owner | 12/17/2014 | 12,075 |
| JOHNSON & JOHNSON | 10% Owner | 12/16/2014 | 49,648 |
| JOHNSON & JOHNSON | 10% Owner | 12/12/2014 | 27,374 |
| JOHNSON & JOHNSON | 10% Owner | 12/11/2014 | 10,163 |
| JOHNSON & JOHNSON | 10% Owner | 12/10/2014 | 10,010 |
| JOHNSON & JOHNSON | 10% Owner | 12/09/2014 | 38,650 |
| JOHNSON & JOHNSON | 10% Owner | 12/08/2014 | 15,380 |
| JOHNSON & JOHNSON | 10% Owner | 12/05/2014 | 32,676 |
| JOHNSON & JOHNSON | 10% Owner | 12/04/2014 | 78,166 |
| JOHNSON & JOHNSON | 10% Owner | 12/03/2014 | 12,609 |
| JOHNSON & JOHNSON | 10% Owner | 12/01/2014 | 9,048 |
| JOHNSON & JOHNSON | 10% Owner | 11/26/2014 | 3,800 |
| JOHNSON & JOHNSON | 10% Owner | 11/25/2014 | 11,700 |
| JOHNSON & JOHNSON | 10% Owner | 11/24/2014 | 32,080 |
| JOHNSON & JOHNSON | 10% Owner | 11/21/2014 | 19,800 |
| JOHNSON & JOHNSON | 10% Owner | 11/20/2014 | 25,451 |
| PFIZER INC | 10% Owner | 03/12/2014 | 2,999,997 |
| Main David | President and CEO | 03/12/2014 | 104,049 |
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