AMGEN Inc.. (AMGN) NASDAQ
$269.12 (2.19) (-0.81%)
Market Cap: $144.03B
As of 12/08/23 04:00 PM EST. Market closed.
AMGEN Inc.. (AMGN)
NASDAQ
$269.12
(2.19) (-0.81%)
Market Cap: $144.03B
As of 12/08/23 04:00 PM EST. Market closed.
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Amgen Inc. is an American multinational biopharmaceutical company headquartered in Thousand Oaks, California. One of the worlds largest independent biotechnology companies, Amgen was established in Thousand Oaks, California, in ... read more
Amgen Inc. is an American multinational biopharmaceutical company headquartered in Thousand Oaks, California. One of the worlds largest independent biotechnology companies, Amgen was established in Thousand Oaks, California, in 1980. read less
COMPANY PROFILE
Sector
Manufacturing
Industry
Biological Product (except Diagnostic) Manufacturing
CEO
Robert Bradway
Full Time Employees
25,200
CEO Compensation (Base)
$1.57M
CEO Compensation (Total)
$18.56M
Sector
Manufacturing
Industry
Biological Product (except Diagnostic) Manufacturing
CEO
Robert Bradway
Full Time Employees
25,200
CEO Compensation (Base)
$1.57M
CEO Compensation (Total)
$18.56M
URL
Address
1 Amgen Center Dr, California, Thousand Oaks, 91320-1799.
PRICE CHART FOR AMGEN INC.
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NEWS
INSIDEARBITRAGE ARTICLES
KEY STATS
Open
$270.03
Previous Close
$271.31
Days Range
$268.82 - $271.97
52 week range
$206.74 - $283.98
Volume
2,608,218
Avg. Volume (30 days)
2,110,389
Market Cap
$144.03B
Dividend Yield
3.11%
P/E
19.04
Shares Outstanding
535,178,027
Open
$270.03
Previous Close
$271.31
Days Range
$268.82 - $271.97
52 week range
$206.74 - $283.98
Volume
2,608,218
Avg. Volume (30 days)
2,110,389
Market Cap
$144.03B
Dividend Yield
3.11%
P/E
19.04
Shares Outstanding
535,178,027
FINANCIAL STATEMENTS FOR AMGEN INC.
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INSIDER TRANSACTIONS FOR AMGEN INC.
| Owner | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| Grygiel Nancy A. | SVP & CCO | Dec 04, 2023 | Sale | $273.03 | 2,096 | 572,276 | 10,874 | Dec 04, 2023, 07:41 PM |
| Graham Jonathan P | EVP, Gen. Counsel & Secy. | Nov 08, 2023 | Sale | $272.81 | 10,000 | 2,728,136 | 28,078 | Nov 13, 2023, 08:30 PM |
| Miller Derek | SVP, Human Resources | Nov 05, 2023 | Option Exercise | $269.86 | 66 | 17,811 | 7,533 | Nov 07, 2023, 08:20 PM |
| Khosla Rachna | SVP, Business Development | Nov 05, 2023 | Option Exercise | $269.86 | 317 | 85,546 | 7,467 | Nov 07, 2023, 08:16 PM |
| Grygiel Nancy A. | SVP & CCO | Nov 05, 2023 | Option Exercise | $269.86 | 249 | 67,195 | 12,970 | Nov 07, 2023, 08:15 PM |
| Busch Matthew C. | VP, Finance & CAO | Nov 05, 2023 | Option Exercise | $269.86 | 249 | 67,195 | 4,550 | Nov 07, 2023, 08:12 PM |
| Griffith Peter H. | EVP & CFO | Nov 01, 2023 | Option Exercise | $255.70 | 3,502 | 895,461 | 28,820 | Nov 03, 2023, 07:44 PM |
| Graham Jonathan P | EVP, Gen. Counsel & Secy. | Nov 01, 2023 | Option Exercise | $255.70 | 1,751 | 447,731 | 38,078 | Nov 03, 2023, 07:43 PM |
| Gordon Murdo | EVP, Global Commercial Ops | Aug 10, 2023 | Sale | $262.43 | 9,558 | 2,508,306 | 44,308 | Aug 11, 2023, 06:13 PM |
| Grygiel Nancy A. | SVP & CCO | Jul 31, 2023 | Option Exercise | $236.37 | 1,129 | 266,862 | 13,095 | Jul 31, 2023, 08:45 PM |
| Santos Esteban | EVP, Operations | May 05, 2023 | Option Exercise | $231.89 | 579 | 134,264 | 63,582 | May 09, 2023, 07:33 PM |
| REESE DAVID M | EVP, Research and Development | May 05, 2023 | Option Exercise | $231.89 | 594 | 137,743 | 54,114 | May 09, 2023, 07:24 PM |
| Miller Derek | SVP, Human Resources | May 05, 2023 | Option Exercise | $231.89 | 51 | 11,826 | 7,553 | May 09, 2023, 07:23 PM |
| Louie Linda H. | VP, Finance & CAO | May 05, 2023 | Option Exercise | $231.89 | 16 | 3,710 | 9,966 | May 09, 2023, 07:21 PM |
| Khosla Rachna | SVP, Business Development | May 05, 2023 | Option Exercise | $231.89 | 39 | 9,044 | 7,581 | May 09, 2023, 07:19 PM |
| Grygiel Nancy A. | SVP & CCO | May 05, 2023 | Option Exercise | $231.89 | 54 | 12,522 | 14,224 | May 09, 2023, 07:17 PM |
| Griffith Peter H. | EVP & CFO | May 05, 2023 | Option Exercise | $231.89 | 608 | 140,989 | 31,990 | May 09, 2023, 07:16 PM |
| Graham Jonathan P | EVP, Gen. Counsel & Secy. | May 05, 2023 | Option Exercise | $231.89 | 592 | 137,279 | 39,573 | May 09, 2023, 07:14 PM |
| Gordon Murdo | EVP, Global Commercial Ops | May 05, 2023 | Option Exercise | $231.89 | 623 | 144,467 | 53,866 | May 09, 2023, 07:13 PM |
| Bradway Robert A | Chairman, CEO and President | May 05, 2023 | Option Exercise | $231.89 | 2,083 | 483,027 | 641,734 | May 09, 2023, 07:11 PM |
| Grygiel Nancy A. | SVP & CCO | May 03, 2023 | Option Exercise | $235.97 | 62 | 14,630 | 14,278 | May 04, 2023, 08:35 PM |
| Santos Esteban | EVP, Operations | May 03, 2023 | Option Exercise | $235.97 | 716 | 168,955 | 64,161 | May 04, 2023, 08:33 PM |
| REESE DAVID M | EVP, Research and Development | May 03, 2023 | Option Exercise | $235.97 | 819 | 193,259 | 54,708 | May 04, 2023, 08:32 PM |
| Miller Derek | SVP, Human Resources | May 03, 2023 | Option Exercise | $235.97 | 57 | 13,450 | 7,604 | May 04, 2023, 08:31 PM |
| Louie Linda H. | VP, Finance & CAO | May 02, 2023 | Option Exercise | $235.97 | 20 | 4,719 | 9,982 | May 04, 2023, 08:30 PM |
| Khosla Rachna | SVP, Business Development | May 03, 2023 | Option Exercise | $235.97 | 57 | 13,450 | 7,620 | May 04, 2023, 08:28 PM |
| Gordon Murdo | EVP, Global Commercial Ops | May 03, 2023 | Option Exercise | $235.97 | 859 | 202,698 | 54,489 | May 04, 2023, 08:27 PM |
| Graham Jonathan P | EVP, Gen. Counsel & Secy. | May 03, 2023 | Option Exercise | $235.97 | 602 | 142,054 | 40,165 | May 04, 2023, 08:25 PM |
| Bradway Robert A | Chairman, CEO and President | May 03, 2023 | Option Exercise | $235.97 | 2,863 | 675,582 | 643,817 | May 04, 2023, 08:23 PM |
| Santos Esteban | EVP, Operations | Apr 30, 2023 | Option Exercise | $239.74 | 660 | 158,228 | 61,318 | May 02, 2023, 08:29 PM |
| REESE DAVID M | EVP, Research and Development | Apr 30, 2023 | Option Exercise | $239.74 | 666 | 159,667 | 51,713 | May 02, 2023, 08:28 PM |
| Miller Derek | SVP, Human Resources | Apr 30, 2023 | Option Exercise | $239.74 | 50 | 11,987 | 6,560 | May 02, 2023, 08:26 PM |
| Louie Linda H. | VP, Finance & CAO | Apr 30, 2023 | Option Exercise | $239.74 | 27 | 6,473 | 9,579 | May 02, 2023, 08:24 PM |
| Khosla Rachna | SVP, Business Development | Apr 30, 2023 | Option Exercise | $239.74 | 47 | 11,268 | 7,084 | May 02, 2023, 08:24 PM |
| Grygiel Nancy A. | SVP & CCO | Apr 30, 2023 | Option Exercise | $239.74 | 73 | 17,501 | 13,705 | May 02, 2023, 08:23 PM |
| Griffith Peter H. | EVP & CFO | Apr 30, 2023 | Option Exercise | $239.74 | 583 | 139,768 | 28,784 | May 02, 2023, 08:21 PM |
| Graham Jonathan P | EVP, Gen. Counsel & Secy. | Apr 30, 2023 | Option Exercise | $239.74 | 664 | 159,187 | 37,377 | May 02, 2023, 08:19 PM |
| Gordon Murdo | EVP, Global Commercial Ops | Apr 30, 2023 | Option Exercise | $239.74 | 728 | 174,531 | 51,111 | May 02, 2023, 08:16 PM |
| Bradway Robert A | Chairman, CEO and President | Apr 30, 2023 | Option Exercise | $239.74 | 2,208 | 529,346 | 633,194 | May 02, 2023, 08:15 PM |
| Santos Esteban | EVP, Operations | Mar 17, 2023 | Option Exercise | $234.57 | 3,881 | 910,366 | 61,978 | Mar 20, 2023, 07:16 PM |
| REESE DAVID M | EVP, Research and Development | Mar 17, 2023 | Option Exercise | $234.57 | 3,978 | 933,119 | 52,379 | Mar 20, 2023, 07:14 PM |
| Miller Derek | SVP, Human Resources | Mar 17, 2023 | Option Exercise | $234.57 | 322 | 75,532 | 6,610 | Mar 20, 2023, 07:13 PM |
| Louie Linda H. | VP, Finance & CAO | Mar 17, 2023 | Option Exercise | $234.57 | 96 | 22,519 | 9,606 | Mar 20, 2023, 07:12 PM |
| Khosla Rachna | SVP, Business Development | Mar 17, 2023 | Option Exercise | $234.57 | 241 | 56,531 | 7,103 | Mar 20, 2023, 07:10 PM |
| Grygiel Nancy A. | SVP & CCO | Mar 17, 2023 | Option Exercise | $234.57 | 339 | 79,519 | 13,778 | Mar 20, 2023, 07:09 PM |
| Griffith Peter H. | EVP & CFO | Mar 17, 2023 | Option Exercise | $234.57 | 3,403 | 798,242 | 29,367 | Mar 20, 2023, 07:08 PM |
| Graham Jonathan P | EVP, Gen. Counsel & Secy. | Mar 17, 2023 | Option Exercise | $234.57 | 3,785 | 887,847 | 38,041 | Mar 20, 2023, 07:07 PM |
| Gordon Murdo | EVP, Global Commercial Ops | Mar 17, 2023 | Option Exercise | $234.57 | 3,978 | 933,119 | 51,839 | Mar 20, 2023, 07:05 PM |
| Bradway Robert A | Chairman, CEO and President | Mar 17, 2023 | Option Exercise | $234.57 | 13,971 | 3,277,178 | 635,402 | Mar 20, 2023, 06:42 PM |
| Khosla Rachna | SVP, Business Development | Nov 09, 2022 | Sale | $292.90 | 387 | 113,352 | 6,630 | Nov 10, 2022, 09:20 PM |
| Miller Derek | SVP, Human Resources | Nov 05, 2022 | Option Exercise | $269.04 | 63 | 16,950 | 5,973 | Nov 08, 2022, 06:44 PM |
| Louie Linda H. | VP, Finance & CAO | Nov 05, 2022 | Option Exercise | $269.04 | 45 | 12,107 | 9,278 | Nov 08, 2022, 06:43 PM |
| Khosla Rachna | SVP, Business Development | Nov 05, 2022 | Option Exercise | $269.04 | 168 | 45,199 | 7,017 | Nov 08, 2022, 06:42 PM |
| Grygiel Nancy A. | SVP & CCO | Nov 05, 2022 | Option Exercise | $269.04 | 240 | 64,570 | 13,554 | Nov 08, 2022, 06:38 PM |
| Grygiel Nancy A. | SVP & CCO | Nov 08, 2022 | Sale | $293.54 | 545 | 159,977 | 13,009 | Nov 08, 2022, 06:38 PM |
| REESE DAVID M | EVP, Research and Development | Nov 02, 2022 | Option Exercise | $272.06 | 2,440 | 663,826 | 48,136 | Nov 03, 2022, 09:38 PM |
| Louie Linda H. | VP, Finance & CAO | Nov 02, 2022 | Option Exercise | $272.06 | 125 | 34,007 | 9,323 | Nov 03, 2022, 09:36 PM |
| Griffith Peter H. | EVP & CFO | Nov 01, 2022 | Option Exercise | $270.35 | 3,030 | 819,161 | 24,675 | Nov 01, 2022, 07:47 PM |
| Graham Jonathan P | EVP, Gen. Counsel & Secy. | Nov 01, 2022 | Option Exercise | $270.35 | 1,644 | 444,455 | 33,963 | Nov 01, 2022, 07:46 PM |
| Williams R Sanders | Director | Aug 22, 2022 | Sale | $249.96 | 200 | 49,992 | 5,301 | Aug 22, 2022, 09:03 PM |
| ECKERT ROBERT | Director | Aug 18, 2022 | Sale | $249.00 | 6,600 | 1,643,380 | 21,184 | Aug 19, 2022, 06:16 PM |
| ECKERT ROBERT | Director | Aug 10, 2022 | Option Exercise | $252.09 | 6,791 | 1,711,943 | 27,784 | Aug 12, 2022, 05:38 PM |
| ECKERT ROBERT | Director | Aug 10, 2022 | Option Exercise | $85.59 | 20,000 | 1,711,800 | 34,575 | Aug 12, 2022, 05:38 PM |
| Khosla Rachna | SVP, Business Development | Jul 31, 2022 | Option Exercise | $247.47 | 217 | 53,701 | 7,158 | Aug 02, 2022, 09:24 PM |
| Grygiel Nancy A. | SVP & CCO | Jul 31, 2022 | Option Exercise | $247.47 | 1,229 | 304,141 | 13,728 | Aug 02, 2022, 09:22 PM |
| Williams R Sanders | Director | May 23, 2022 | Sale | $250.00 | 600 | 150,000 | 5,501 | May 23, 2022, 09:19 PM |
| Graham Jonathan P | EVP, Gen. Counsel & Secy. | May 10, 2022 | Sale | $241.81 | 13,500 | 3,264,449 | 37,333 | May 10, 2022, 07:45 PM |
| Santos Esteban | EVP, Operations | May 05, 2022 | Option Exercise | $236.10 | 589 | 139,063 | 57,661 | May 09, 2022, 07:14 PM |
| REESE DAVID M | EVP, Research and Development | May 05, 2022 | Option Exercise | $236.10 | 575 | 135,758 | 50,307 | May 09, 2022, 07:12 PM |
| Miller Derek | SVP, Human Resources | May 05, 2022 | Option Exercise | $236.10 | 49 | 11,569 | 6,006 | May 09, 2022, 07:10 PM |
| Louie Linda H. | VP, Finance & CAO | May 05, 2022 | Option Exercise | $236.10 | 15 | 3,542 | 9,404 | May 09, 2022, 07:09 PM |
| Khosla Rachna | SVP, Business Development | May 05, 2022 | Option Exercise | $236.10 | 37 | 8,736 | 7,344 | May 09, 2022, 07:08 PM |
| Grygiel Nancy A. | SVP & CCO | May 05, 2022 | Option Exercise | $236.10 | 52 | 12,277 | 14,869 | May 09, 2022, 07:07 PM |
| Griffith Peter H. | EVP & CFO | May 05, 2022 | Option Exercise | $236.10 | 589 | 139,063 | 27,340 | May 09, 2022, 07:05 PM |
| Graham Jonathan P | EVP, Gen. Counsel & Secy. | May 05, 2022 | Option Exercise | $236.10 | 574 | 135,521 | 50,833 | May 09, 2022, 07:03 PM |
| Gordon Murdo | EVP Global Commercial Ops | May 05, 2022 | Option Exercise | $236.10 | 603 | 142,368 | 47,784 | May 09, 2022, 07:02 PM |
| Bradway Robert A | Chairman, CEO and President | May 05, 2022 | Option Exercise | $236.10 | 2,017 | 476,214 | 619,841 | May 09, 2022, 07:00 PM |
| Santos Esteban | EVP, Operations | May 03, 2022 | Option Exercise | $230.92 | 708 | 163,491 | 58,250 | May 04, 2022, 08:10 PM |
| REESE DAVID M | EVP, Research and Development | May 03, 2022 | Option Exercise | $230.92 | 770 | 177,808 | 50,882 | May 04, 2022, 08:07 PM |
| Miller Derek | SVP, Human Resources | May 03, 2022 | Option Exercise | $230.92 | 54 | 12,470 | 6,055 | May 04, 2022, 08:05 PM |
| Louie Linda H. | VP, Finance & CAO | May 03, 2022 | Option Exercise | $230.92 | 18 | 4,157 | 9,419 | May 04, 2022, 08:02 PM |
| Khosla Rachna | SVP, Business Development | May 03, 2022 | Option Exercise | $230.92 | 53 | 12,239 | 7,381 | May 04, 2022, 08:00 PM |
| Grygiel Nancy A. | SVP & CCO | May 02, 2022 | Option Exercise | $230.92 | 57 | 13,162 | 14,921 | May 04, 2022, 07:57 PM |
| Graham Jonathan P | EVP, Gen. Counsel & Secy. | May 03, 2022 | Option Exercise | $230.92 | 566 | 130,701 | 51,407 | May 04, 2022, 07:51 PM |
| Gordon Murdo | EVP Global Commercial Ops | May 03, 2022 | Option Exercise | $230.92 | 808 | 186,583 | 48,387 | May 04, 2022, 07:48 PM |
| Bradway Robert A | Chairman, CEO and President | May 03, 2022 | Option Exercise | $230.92 | 2,692 | 621,637 | 621,858 | May 04, 2022, 07:44 PM |
| Santos Esteban | EVP, Operations | Apr 27, 2022 | Option Exercise | $249.87 | 599 | 149,672 | 55,321 | Apr 29, 2022, 06:49 PM |
| REESE DAVID M | EVP, Research and Development | Apr 27, 2022 | Option Exercise | $249.87 | 184 | 45,976 | 47,755 | Apr 29, 2022, 06:47 PM |
| Miller Derek | SVP, Human Resources | Apr 27, 2022 | Option Exercise | $249.87 | 273 | 68,215 | 5,243 | Apr 29, 2022, 06:45 PM |
| Louie Linda H. | VP, Finance & CAO | Apr 27, 2022 | Option Exercise | $249.87 | 17 | 4,248 | 9,004 | Apr 29, 2022, 06:44 PM |
| Khosla Rachna | SVP, Business Development | Apr 27, 2022 | Option Exercise | $249.87 | 28 | 6,996 | 6,828 | Apr 29, 2022, 06:43 PM |
| Grygiel Nancy A. | SVP & CCO | Apr 27, 2022 | Option Exercise | $249.87 | 60 | 14,992 | 14,329 | Apr 29, 2022, 06:41 PM |
| Graham Jonathan P | EVP, Gen. Counsel & Secy. | Apr 27, 2022 | Option Exercise | $249.87 | 599 | 149,672 | 48,596 | Apr 29, 2022, 06:39 PM |
| Bradway Robert A | Chairman, CEO and President | Apr 27, 2022 | Option Exercise | $249.87 | 2,547 | 636,419 | 610,769 | Apr 29, 2022, 06:37 PM |
| Santos Esteban | EVP, Operations | Mar 18, 2022 | Option Exercise | $235.86 | 4,370 | 1,030,708 | 55,920 | Mar 22, 2022, 05:49 PM |
| REESE DAVID M | EVP, Research and Development | Mar 18, 2022 | Option Exercise | $235.86 | 4,995 | 1,178,121 | 47,939 | Mar 22, 2022, 05:47 PM |
| Miller Derek | SVP, Human Resources | Mar 18, 2022 | Option Exercise | $235.86 | 327 | 77,126 | 5,516 | Mar 22, 2022, 05:46 PM |
| Louie Linda H. | VP, Finance & CAO | Mar 18, 2022 | Option Exercise | $235.86 | 108 | 25,473 | 9,021 | Mar 22, 2022, 05:44 PM |
| Khosla Rachna | SVP, Business Development | Mar 18, 2022 | Option Exercise | $235.86 | 322 | 75,947 | 6,856 | Mar 22, 2022, 05:42 PM |
| Grygiel Nancy A. | SVP & CCO | Mar 18, 2022 | Option Exercise | $235.86 | 350 | 82,551 | 14,389 | Mar 22, 2022, 05:41 PM |
| Graham Jonathan P | EVP, Gen. Counsel & Secy. | Mar 18, 2022 | Option Exercise | $235.86 | 3,496 | 824,567 | 49,195 | Mar 22, 2022, 05:40 PM |
| Gordon Murdo | EVP Global Commercial Ops | Mar 18, 2022 | Option Exercise | $235.86 | 4,995 | 1,178,121 | 44,865 | Mar 22, 2022, 05:38 PM |
| Bradway Robert A | Chairman, CEO and President | Mar 18, 2022 | Option Exercise | $235.86 | 17,481 | 4,123,069 | 613,316 | Mar 22, 2022, 05:37 PM |
| REESE DAVID M | EVP, Research and Development | Nov 02, 2021 | Option Exercise | $209.74 | 2,192 | 459,750 | 42,593 | Nov 03, 2021, 07:27 PM |
| Gordon Murdo | EVP Global Commercial Ops | Nov 02, 2021 | Option Exercise | $209.79 | 5,585 | 1,171,677 | 39,602 | Nov 03, 2021, 07:26 PM |
| Johnston Lori A | EVP, HR | Nov 01, 2021 | Option Exercise | $206.97 | 1,352 | 279,823 | 36,269 | Nov 03, 2021, 07:24 PM |
| Griffith Peter H. | EVP & CFO | Nov 01, 2021 | Option Exercise | $206.97 | 2,661 | 550,747 | 23,700 | Nov 03, 2021, 07:22 PM |
| Graham Jonathan P | EVP, Gen. Counsel & Secy. | Nov 01, 2021 | Option Exercise | $206.97 | 1,591 | 329,289 | 45,353 | Nov 03, 2021, 07:21 PM |
| Grygiel Nancy A. | SVP & CCO | May 11, 2021 | Option Exercise | $162.60 | 2,500 | 406,500 | 14,961 | May 12, 2021, 08:10 PM |
| Grygiel Nancy A. | SVP & CCO | May 11, 2021 | Sale | $252.51 | 2,500 | 631,273 | 12,461 | May 12, 2021, 08:10 PM |
| Williams R Sanders | Director | May 07, 2021 | Sale | $251.78 | 250 | 62,945 | 4,409 | May 10, 2021, 06:38 PM |
| Santos Esteban | EVP, Operations | May 03, 2021 | Option Exercise | $239.64 | 685 | 164,153 | 51,108 | May 04, 2021, 07:44 PM |
| Santos Esteban | EVP, Operations | May 01, 2021 | Option Exercise | $239.64 | 651 | 156,006 | 51,793 | May 04, 2021, 07:44 PM |
| REESE DAVID M | EVP, Research and Development | May 03, 2021 | Option Exercise | $239.64 | 745 | 178,532 | 44,472 | May 04, 2021, 07:41 PM |
| REESE DAVID M | EVP, Research and Development | May 01, 2021 | Option Exercise | $239.64 | 1,109 | 265,761 | 45,217 | May 04, 2021, 07:41 PM |
| Piacquad David | SVP, Business Development | May 03, 2021 | Option Exercise | $239.64 | 220 | 52,721 | 44,787 | May 04, 2021, 07:38 PM |
| Piacquad David | SVP, Business Development | May 01, 2021 | Option Exercise | $239.64 | 139 | 33,310 | 45,007 | May 04, 2021, 07:38 PM |
| Johnston Lori A | EVP, HR | May 03, 2021 | Option Exercise | $239.64 | 335 | 80,279 | 37,365 | May 04, 2021, 07:31 PM |
| Johnston Lori A | EVP, HR | May 01, 2021 | Option Exercise | $239.64 | 355 | 85,072 | 37,700 | May 04, 2021, 07:31 PM |
| Grygiel Nancy A. | SVP & CCO | May 03, 2021 | Option Exercise | $239.64 | 55 | 13,180 | 12,461 | May 04, 2021, 07:21 PM |
| Grygiel Nancy A. | SVP & CCO | May 01, 2021 | Option Exercise | $239.64 | 62 | 14,858 | 12,516 | May 04, 2021, 07:21 PM |
| Graham Jonathan P | EVP, Gen. Counsel & Secy. | May 03, 2021 | Option Exercise | $239.64 | 548 | 131,323 | 46,633 | May 04, 2021, 07:15 PM |
| Graham Jonathan P | EVP, Gen. Counsel & Secy. | May 01, 2021 | Option Exercise | $239.64 | 581 | 139,231 | 47,181 | May 04, 2021, 07:15 PM |
| Gordon Murdo | EVP Global Commercial Ops | May 03, 2021 | Option Exercise | $239.64 | 782 | 187,398 | 44,848 | May 04, 2021, 07:12 PM |
| Bradway Robert A | Chairman, CEO and President | May 03, 2021 | Option Exercise | $239.64 | 2,850 | 682,974 | 594,173 | May 03, 2021, 09:44 PM |
| Bradway Robert A | Chairman, CEO and President | May 01, 2021 | Option Exercise | $239.64 | 2,902 | 695,435 | 597,023 | May 03, 2021, 09:44 PM |
| Santos Esteban | EVP, Operations | Apr 27, 2021 | Option Exercise | $255.52 | 564 | 144,113 | 48,480 | Apr 28, 2021, 08:20 PM |
| REESE DAVID M | EVP, Research and Development | Apr 27, 2021 | Option Exercise | $255.52 | 174 | 44,460 | 42,320 | Apr 28, 2021, 08:17 PM |
| Piacquad David | SVP, Business Development | Apr 27, 2021 | Option Exercise | $255.52 | 128 | 32,707 | 44,437 | Apr 28, 2021, 08:14 PM |
| Louie Linda H. | VP, Finance & CAO | Apr 27, 2021 | Option Exercise | $255.52 | 16 | 4,088 | 8,001 | Apr 28, 2021, 08:11 PM |
| Johnston Lori A | EVP, HR | Apr 27, 2021 | Option Exercise | $255.52 | 345 | 88,154 | 34,759 | Apr 28, 2021, 08:08 PM |
| Grygiel Nancy A. | SVP & CCO | Apr 27, 2021 | Option Exercise | $255.52 | 57 | 14,565 | 11,994 | Apr 28, 2021, 08:05 PM |
| Graham Jonathan P | EVP, Gen. Counsel & Secy. | Apr 27, 2021 | Option Exercise | $255.52 | 564 | 144,113 | 43,965 | Apr 28, 2021, 08:01 PM |
| SUGAR RONALD D | Director | Apr 14, 2021 | Option Exercise | $71.64 | 1,000 | 71,640 | 16,927 | Apr 15, 2021, 06:27 PM |
| SUGAR RONALD D | Director | Apr 14, 2021 | Sale | $249.98 | 1,000 | 249,980 | 15,927 | Apr 15, 2021, 06:27 PM |
| Santos Esteban | EVP, Operations | Mar 19, 2021 | Option Exercise | $244.42 | 4,360 | 1,065,671 | 49,044 | Mar 22, 2021, 06:36 PM |
| REESE DAVID M | EVP, Research and Development | Mar 19, 2021 | Option Exercise | $244.42 | 1,401 | 342,432 | 42,494 | Mar 22, 2021, 06:34 PM |
| Piacquad David | SVP, Business Development | Mar 19, 2021 | Option Exercise | $244.42 | 991 | 242,220 | 44,565 | Mar 22, 2021, 06:33 PM |
| Louie Linda H. | VP, Finance & CAO | Mar 19, 2021 | Option Exercise | $244.42 | 115 | 28,108 | 8,017 | Mar 22, 2021, 06:31 PM |
| Johnston Lori A | EVP, HR | Mar 19, 2021 | Option Exercise | $244.42 | 2,803 | 685,109 | 35,104 | Mar 22, 2021, 06:30 PM |
| Grygiel Nancy A. | SVP & CCO | Mar 19, 2021 | Option Exercise | $244.42 | 435 | 106,323 | 12,051 | Mar 22, 2021, 06:28 PM |
| Graham Jonathan P | EVP, Gen. Counsel & Secy. | Mar 19, 2021 | Option Exercise | $244.42 | 4,360 | 1,065,671 | 44,529 | Mar 22, 2021, 06:26 PM |
| Gordon Murdo | EVP Global Commercial Ops | Mar 19, 2021 | Option Exercise | $244.42 | 8,989 | 2,197,091 | 41,458 | Mar 22, 2021, 06:24 PM |
| Bradway Robert A | Chairman, CEO and President | Mar 19, 2021 | Option Exercise | $244.42 | 21,190 | 5,179,260 | 589,262 | Mar 22, 2021, 06:21 PM |
| SUGAR RONALD D | Director | Mar 10, 2021 | Option Exercise | $71.64 | 1,000 | 71,640 | 16,805 | Mar 10, 2021, 06:07 PM |
| SUGAR RONALD D | Director | Mar 10, 2021 | Sale | $231.53 | 1,000 | 231,530 | 15,805 | Mar 10, 2021, 06:07 PM |
| Bradway Robert A | Chairman, CEO and President | Feb 18, 2021 | Option Exercise | $235.61 | 47,527 | 11,197,836 | 570,853 | Feb 22, 2021, 07:27 PM |
| Bradway Robert A | Chairman, CEO and President | Feb 18, 2021 | Option Exercise | $54.69 | 73,500 | 4,019,715 | 618,380 | Feb 22, 2021, 07:27 PM |
| REESE DAVID M | EVP, Research and Development | Feb 16, 2021 | Option Exercise | $237.21 | 1,147 | 272,080 | 40,912 | Feb 16, 2021, 08:59 PM |
| REESE DAVID M | EVP, Research and Development | Feb 16, 2021 | Option Exercise | $54.69 | 2,300 | 125,787 | 42,059 | Feb 16, 2021, 08:59 PM |
| SUGAR RONALD D | Director | Feb 10, 2021 | Option Exercise | $71.64 | 1,000 | 71,640 | 16,805 | Feb 10, 2021, 07:40 PM |
| SUGAR RONALD D | Director | Feb 10, 2021 | Sale | $238.40 | 1,000 | 238,400 | 15,805 | Feb 10, 2021, 07:40 PM |
| Johnston Lori A | EVP, HR | Feb 07, 2021 | Option Exercise | $236.32 | 474 | 112,016 | 32,074 | Feb 09, 2021, 08:03 PM |
| Williams R Sanders | Director | Feb 08, 2021 | Sale | $237.99 | 250 | 59,498 | 4,659 | Feb 08, 2021, 08:36 PM |
| Graham Jonathan P | EVP, Gen. Counsel & Secy. | Feb 04, 2021 | Sale | $236.51 | 11,110 | 2,627,626 | 39,945 | Feb 05, 2021, 08:06 PM |
| SUGAR RONALD D | Director | Jan 13, 2021 | Option Exercise | $71.64 | 1,000 | 71,640 | 16,805 | Jan 14, 2021, 06:25 PM |
| SUGAR RONALD D | Director | Jan 13, 2021 | Sale | $235.99 | 1,000 | 235,990 | 15,805 | Jan 14, 2021, 06:25 PM |
| Williams R Sanders | Director | Nov 09, 2020 | Sale | $242.40 | 250 | 60,600 | 4,909 | Nov 10, 2020, 06:32 PM |
| REESE DAVID M | EVP, Research and Development | Nov 02, 2020 | Option Exercise | $216.94 | 2,125 | 460,998 | 39,619 | Nov 04, 2020, 07:06 PM |
| Gordon Murdo | EVP Global Commercial Ops | Nov 02, 2020 | Option Exercise | $216.94 | 6,269 | 1,359,997 | 32,036 | Nov 04, 2020, 07:00 PM |
| SUGAR RONALD D | Director | Aug 19, 2020 | Option Exercise | $54.69 | 1,000 | 54,690 | 16,589 | Aug 19, 2020, 06:00 PM |
| SUGAR RONALD D | Director | Aug 19, 2020 | Sale | $241.02 | 1,000 | 241,020 | 15,589 | Aug 19, 2020, 06:00 PM |
| Williams R Sanders | Director | Aug 07, 2020 | Sale | $242.95 | 250 | 60,737 | 5,159 | Aug 10, 2020, 05:42 PM |
| Santos Esteban | EVP, Operations | Aug 01, 2020 | Option Exercise | $244.67 | 2,165 | 529,711 | 44,376 | Aug 03, 2020, 06:47 PM |
| Grygiel Nancy A. | SVP & CCO | Aug 03, 2020 | Option Exercise | $244.67 | 290 | 70,954 | 11,026 | Aug 03, 2020, 06:46 PM |
| SUGAR RONALD D | Director | Jul 22, 2020 | Option Exercise | $54.69 | 1,000 | 54,690 | 16,589 | Jul 22, 2020, 06:11 PM |
| SUGAR RONALD D | Director | Jul 22, 2020 | Sale | $259.79 | 1,000 | 259,790 | 15,589 | Jul 22, 2020, 06:11 PM |
| SUGAR RONALD D | Director | Jun 17, 2020 | Option Exercise | $54.69 | 1,000 | 54,690 | 16,576 | Jun 17, 2020, 06:11 PM |
| SUGAR RONALD D | Director | Jun 17, 2020 | Sale | $228.54 | 1,000 | 228,540 | 15,576 | Jun 17, 2020, 06:11 PM |
| SUGAR RONALD D | Director | May 20, 2020 | Option Exercise | $54.69 | 1,000 | 54,690 | 16,482 | May 20, 2020, 09:24 PM |
| SUGAR RONALD D | Director | May 20, 2020 | Sale | $229.27 | 1,000 | 229,270 | 15,482 | May 20, 2020, 09:24 PM |
| Williams R Sanders | Director | May 06, 2020 | Sale | $237.31 | 425 | 100,857 | 5,409 | May 07, 2020, 08:49 PM |
| Santos Esteban | EVP, Operations | May 03, 2020 | Option Exercise | $230.98 | 194 | 44,810 | 43,049 | May 05, 2020, 08:00 PM |
| Santos Esteban | EVP, Operations | May 01, 2020 | Option Exercise | $239.22 | 593 | 141,857 | 43,243 | May 05, 2020, 08:00 PM |
| REESE DAVID M | EVP, Research and Development | May 03, 2020 | Option Exercise | $230.98 | 185 | 42,731 | 37,939 | May 05, 2020, 07:57 PM |
| REESE DAVID M | EVP, Research and Development | May 01, 2020 | Option Exercise | $239.22 | 1,046 | 250,224 | 38,124 | May 05, 2020, 07:57 PM |
| Piacquad David | SVP, Business Development | May 03, 2020 | Option Exercise | $230.98 | 136 | 31,413 | 41,504 | May 05, 2020, 07:55 PM |
| Piacquad David | SVP, Business Development | May 01, 2020 | Option Exercise | $239.22 | 123 | 29,424 | 41,640 | May 05, 2020, 07:55 PM |
| Patton Cynthia M | SVP & CCO | May 03, 2020 | Option Exercise | $230.98 | 127 | 29,334 | 24,075 | May 05, 2020, 07:53 PM |
| Patton Cynthia M | SVP & CCO | May 01, 2020 | Option Exercise | $239.22 | 115 | 27,510 | 24,202 | May 05, 2020, 07:53 PM |
| Johnston Lori A | EVP, HR | May 01, 2020 | Option Exercise | $239.22 | 335 | 80,139 | 29,307 | May 05, 2020, 07:52 PM |
| Graham Jonathan P | EVP, Gen. Counsel & Secy. | May 01, 2020 | Option Exercise | $239.22 | 549 | 131,332 | 47,911 | May 05, 2020, 07:51 PM |
| Graham Jonathan P | EVP, Gen. Counsel & Secy. | May 03, 2020 | Option Exercise | $230.98 | 555 | 128,194 | 47,356 | May 05, 2020, 07:51 PM |
| Bradway Robert A | Chairman, CEO and President | May 03, 2020 | Option Exercise | $230.98 | 2,759 | 637,274 | 531,782 | May 05, 2020, 07:48 PM |
| Bradway Robert A | Chairman, CEO and President | May 01, 2020 | Option Exercise | $239.22 | 2,737 | 654,745 | 534,541 | May 05, 2020, 07:48 PM |
| Santos Esteban | EVP, Operations | Apr 27, 2020 | Option Exercise | $236.28 | 526 | 124,283 | 43,836 | Apr 29, 2020, 07:07 PM |
| REESE DAVID M | EVP, Research and Development | Apr 27, 2020 | Option Exercise | $236.28 | 168 | 39,695 | 39,170 | Apr 29, 2020, 07:04 PM |
| Piacquad David | SVP, Business Development | Apr 27, 2020 | Option Exercise | $236.28 | 116 | 27,408 | 41,763 | Apr 29, 2020, 07:02 PM |
| Patton Cynthia M | SVP & CCO | Apr 27, 2020 | Option Exercise | $236.28 | 102 | 24,101 | 24,317 | Apr 29, 2020, 07:00 PM |
| Johnston Lori A | EVP, HR | Apr 27, 2020 | Option Exercise | $236.28 | 335 | 79,154 | 29,642 | Apr 29, 2020, 06:58 PM |
| Graham Jonathan P | EVP, Gen. Counsel & Secy. | Apr 27, 2020 | Option Exercise | $236.28 | 548 | 129,481 | 48,460 | Apr 29, 2020, 06:56 PM |
| Bradway Robert A | Chairman, CEO and President | Apr 27, 2020 | Option Exercise | $236.28 | 2,543 | 600,860 | 537,278 | Apr 29, 2020, 06:52 PM |
| SUGAR RONALD D | Director | Apr 22, 2020 | Option Exercise | $54.69 | 1,000 | 54,690 | 15,636 | Apr 22, 2020, 07:07 PM |
| SUGAR RONALD D | Director | Apr 22, 2020 | Sale | $233.35 | 1,000 | 233,350 | 14,636 | Apr 22, 2020, 07:07 PM |
| Bradway Robert A | Chairman, CEO and President | Apr 13, 2020 | Option Exercise | $218.21 | 84,206 | 18,374,592 | 539,821 | Apr 13, 2020, 07:54 PM |
| Bradway Robert A | Chairman, CEO and President | Apr 13, 2020 | Option Exercise | $58.43 | 127,000 | 7,420,610 | 595,516 | Apr 13, 2020, 07:54 PM |
| Santos Esteban | EVP, Operations | Mar 20, 2020 | Option Exercise | $198.76 | 6,465 | 1,284,983 | 44,362 | Mar 24, 2020, 06:10 PM |
| REESE DAVID M | EVP, Research and Development | Mar 20, 2020 | Option Exercise | $198.76 | 1,855 | 368,700 | 39,338 | Mar 24, 2020, 06:09 PM |
| Patton Cynthia M | SVP & CCO | Mar 20, 2020 | Option Exercise | $198.76 | 1,481 | 294,364 | 24,419 | Mar 24, 2020, 06:04 PM |
| Piacquad David | SVP, Business Development | Mar 20, 2020 | Option Exercise | $198.76 | 1,591 | 316,227 | 41,879 | Mar 24, 2020, 06:03 PM |
| Johnston Lori A | EVP, HR | Mar 20, 2020 | Option Exercise | $198.76 | 3,709 | 737,201 | 29,977 | Mar 24, 2020, 06:02 PM |
| Graham Jonathan P | EVP, Gen. Counsel & Secy. | Mar 20, 2020 | Option Exercise | $198.76 | 5,796 | 1,152,013 | 49,008 | Mar 24, 2020, 06:00 PM |
| Bradway Robert A | Chairman, CEO and President | Mar 20, 2020 | Option Exercise | $198.76 | 27,818 | 5,529,106 | 497,027 | Mar 24, 2020, 05:59 PM |
| REESE DAVID M | EVP, Research and Development | Mar 09, 2020 | Option Exercise | $210.65 | 780 | 164,307 | 40,985 | Mar 10, 2020, 09:12 PM |
| REESE DAVID M | EVP, Research and Development | Mar 09, 2020 | Option Exercise | $58.43 | 1,480 | 86,476 | 41,765 | Mar 10, 2020, 09:12 PM |
| Johnston Lori A | EVP, HR | Feb 07, 2020 | Option Exercise | $231.45 | 462 | 106,930 | 26,094 | Feb 11, 2020, 09:16 PM |
| Williams R Sanders | Director | Feb 06, 2020 | Sale | $233.72 | 425 | 99,331 | 4,988 | Feb 10, 2020, 09:33 PM |
| Piacquad David | SVP, Business Development | Feb 06, 2020 | Sale | $229.93 | 9,264 | 2,130,081 | 39,700 | Feb 07, 2020, 08:25 PM |
| Piacquad David | SVP, Business Development | Dec 13, 2019 | Option Exercise | $235.99 | 2,425 | 572,276 | 48,964 | Dec 13, 2019, 08:31 PM |
| Piacquad David | SVP, Business Development | Dec 13, 2019 | Option Exercise | $162.60 | 2,875 | 467,475 | 51,389 | Dec 13, 2019, 08:31 PM |
| Meline David W | EVP & CFO | Nov 25, 2019 | Sale | $234.36 | 8,737 | 2,047,603 | 49,378 | Nov 25, 2019, 06:27 PM |
| Graham Jonathan P | EVP, Gen. Counsel & Secy. | Nov 22, 2019 | Sale | $230.54 | 9,000 | 2,074,833 | 42,853 | Nov 25, 2019, 06:25 PM |
| Piacquad David | SVP, Business Development | Nov 20, 2019 | Option Exercise | $224.50 | 4,870 | 1,093,315 | 48,491 | Nov 20, 2019, 08:09 PM |
| Piacquad David | SVP, Business Development | Nov 20, 2019 | Option Exercise | $156.35 | 5,749 | 898,856 | 53,361 | Nov 20, 2019, 08:09 PM |
| Williams R Sanders | Director | Nov 06, 2019 | Sale | $215.45 | 425 | 91,566 | 5,413 | Nov 07, 2019, 06:22 PM |
| SUGAR RONALD D | Director | Nov 06, 2019 | Option Exercise | $54.71 | 2,000 | 109,420 | 16,436 | Nov 07, 2019, 06:20 PM |
| SUGAR RONALD D | Director | Nov 06, 2019 | Sale | $215.45 | 2,000 | 430,900 | 14,436 | Nov 07, 2019, 06:20 PM |
| Gordon Murdo | EVP Global Commercial Ops | Nov 02, 2019 | Option Exercise | $217.95 | 5,812 | 1,266,725 | 34,024 | Nov 05, 2019, 06:50 PM |
| SUGAR RONALD D | Director | Oct 02, 2019 | Option Exercise | $54.71 | 2,000 | 109,420 | 16,436 | Oct 03, 2019, 05:06 PM |
| SUGAR RONALD D | Director | Oct 02, 2019 | Sale | $193.58 | 2,000 | 387,160 | 14,436 | Oct 03, 2019, 05:06 PM |
| SUGAR RONALD D | Director | Sep 04, 2019 | Option Exercise | $54.71 | 2,000 | 109,420 | 16,336 | Sep 04, 2019, 06:08 PM |
| SUGAR RONALD D | Director | Sep 04, 2019 | Sale | $206.70 | 2,000 | 413,400 | 14,336 | Sep 04, 2019, 06:08 PM |
| Patton Cynthia M | SVP & CCO | Aug 30, 2019 | Option Exercise | $158.43 | 8,624 | 1,366,331 | 32,648 | Sep 04, 2019, 06:07 PM |
| Patton Cynthia M | SVP & CCO | Aug 30, 2019 | Sale | $208.07 | 13,426 | 2,793,508 | 26,899 | Sep 04, 2019, 06:07 PM |
| Williams R Sanders | Director | Aug 07, 2019 | Sale | $183.04 | 425 | 77,792 | 5,838 | Aug 08, 2019, 07:12 PM |
| SUGAR RONALD D | Director | Aug 07, 2019 | Option Exercise | $54.71 | 2,000 | 109,420 | 16,336 | Aug 08, 2019, 07:09 PM |
| SUGAR RONALD D | Director | Aug 07, 2019 | Sale | $183.04 | 2,000 | 366,080 | 14,336 | Aug 08, 2019, 07:09 PM |
| Graham Jonathan P | SVP, Gen. Counsel & Secy. | Aug 04, 2019 | Option Exercise | $187.22 | 6,785 | 1,270,288 | 42,610 | Aug 06, 2019, 06:08 PM |
| Santos Esteban | EVP, Operations | Aug 01, 2019 | Option Exercise | $186.58 | 2,043 | 381,183 | 37,437 | Aug 02, 2019, 05:18 PM |
| SUGAR RONALD D | Director | Jul 03, 2019 | Option Exercise | $54.71 | 2,000 | 109,420 | 16,336 | Jul 08, 2019, 04:23 PM |
| SUGAR RONALD D | Director | Jul 03, 2019 | Sale | $187.58 | 2,000 | 375,160 | 14,336 | Jul 08, 2019, 04:23 PM |
| SUGAR RONALD D | Director | Jun 05, 2019 | Option Exercise | $54.71 | 2,000 | 109,420 | 16,219 | Jun 05, 2019, 06:55 PM |
| SUGAR RONALD D | Director | Jun 05, 2019 | Sale | $175.68 | 2,000 | 351,360 | 14,219 | Jun 05, 2019, 06:55 PM |
| Santos Esteban | EVP, Operations | May 03, 2019 | Option Exercise | $176.50 | 182 | 32,123 | 35,382 | May 07, 2019, 07:08 PM |
| REESE DAVID M | EVP, Research and Development | May 03, 2019 | Option Exercise | $176.50 | 174 | 30,711 | 31,564 | May 07, 2019, 07:06 PM |
| Piacquad David | SVP, Business Development | May 03, 2019 | Option Exercise | $176.50 | 182 | 32,123 | 45,864 | May 07, 2019, 07:04 PM |
| Patton Cynthia M | SVP & CCO | May 03, 2019 | Option Exercise | $176.50 | 174 | 30,711 | 25,975 | May 07, 2019, 07:02 PM |
| Meline David W | EVP & CFO | May 03, 2019 | Option Exercise | $176.50 | 795 | 140,318 | 53,392 | May 07, 2019, 07:00 PM |
| Graham Jonathan P | SVP, Gen. Counsel & Secy. | May 03, 2019 | Option Exercise | $176.50 | 523 | 92,310 | 46,046 | May 07, 2019, 06:57 PM |
| Bradway Robert A | Chairman, CEO and President | May 03, 2019 | Option Exercise | $176.50 | 2,379 | 419,894 | 451,601 | May 07, 2019, 06:52 PM |
| Piacquad David | SVP, Business Development | May 01, 2019 | Option Exercise | $179.32 | 171 | 30,664 | 46,046 | May 03, 2019, 06:02 PM |
| Santos Esteban | EVP, Operations | May 01, 2019 | Option Exercise | $179.32 | 597 | 107,056 | 35,564 | May 03, 2019, 05:57 PM |
| REESE DAVID M | EVP, Research and Development | May 01, 2019 | Option Exercise | $179.32 | 1,014 | 181,834 | 32,859 | May 03, 2019, 05:54 PM |
| Patton Cynthia M | SVP & CCO | May 01, 2019 | Option Exercise | $179.32 | 164 | 29,409 | 26,149 | May 03, 2019, 05:51 PM |
| Meline David W | EVP & CFO | May 01, 2019 | Option Exercise | $179.32 | 746 | 133,775 | 54,187 | May 03, 2019, 05:49 PM |
| Johnston Lori A | SVP, HR | May 01, 2019 | Option Exercise | $179.32 | 341 | 61,149 | 16,505 | May 03, 2019, 05:47 PM |
| Graham Jonathan P | SVP, Gen. Counsel & Secy. | May 01, 2019 | Option Exercise | $179.32 | 532 | 95,400 | 46,569 | May 03, 2019, 05:43 PM |
| Bradway Robert A | Chairman, CEO and President | May 01, 2019 | Option Exercise | $179.32 | 2,433 | 436,293 | 453,980 | May 03, 2019, 05:40 PM |
| SUGAR RONALD D | Director | May 01, 2019 | Option Exercise | $54.71 | 2,000 | 109,420 | 15,092 | May 03, 2019, 05:37 PM |
| SUGAR RONALD D | Director | May 01, 2019 | Sale | $175.73 | 2,000 | 351,460 | 13,092 | May 03, 2019, 05:37 PM |
| SUGAR RONALD D | Director | Apr 03, 2019 | Option Exercise | $54.71 | 2,000 | 109,420 | 15,092 | Apr 03, 2019, 06:27 PM |
| SUGAR RONALD D | Director | Apr 03, 2019 | Sale | $193.18 | 2,000 | 386,360 | 13,092 | Apr 03, 2019, 06:27 PM |
| Santos Esteban | EVP, Operations | Mar 22, 2019 | Option Exercise | $191.89 | 1,838 | 352,694 | 36,161 | Mar 25, 2019, 07:44 PM |
| REESE DAVID M | EVP, Research and Development | Mar 22, 2019 | Option Exercise | $191.89 | 1,769 | 339,453 | 32,752 | Mar 25, 2019, 07:41 PM |
| Piacquad David | SVP, Business Development | Mar 22, 2019 | Option Exercise | $191.89 | 1,509 | 289,562 | 46,217 | Mar 25, 2019, 07:39 PM |
| Patton Cynthia M | SVP & CCO | Mar 22, 2019 | Option Exercise | $191.89 | 1,515 | 290,713 | 26,313 | Mar 25, 2019, 07:38 PM |
| Meline David W | EVP & CFO | Mar 22, 2019 | Option Exercise | $191.89 | 8,040 | 1,542,796 | 54,933 | Mar 25, 2019, 07:36 PM |
| Graham Jonathan P | SVP, Gen. Counsel & Secy. | Mar 22, 2019 | Option Exercise | $191.89 | 5,283 | 1,013,755 | 47,101 | Mar 25, 2019, 07:34 PM |
| Bradway Robert A | Chairman, CEO and President | Mar 22, 2019 | Option Exercise | $191.89 | 25,268 | 4,848,677 | 456,413 | Mar 25, 2019, 07:32 PM |
| SUGAR RONALD D | Director | Mar 06, 2019 | Option Exercise | $54.71 | 2,000 | 109,420 | 14,988 | Mar 08, 2019, 07:47 PM |
| SUGAR RONALD D | Director | Mar 06, 2019 | Sale | $188.88 | 2,000 | 377,760 | 12,988 | Mar 08, 2019, 07:47 PM |
| SUGAR RONALD D | Director | Feb 07, 2019 | Option Exercise | $54.71 | 2,000 | 109,420 | 14,988 | Feb 11, 2019, 09:27 PM |
| SUGAR RONALD D | Director | Feb 07, 2019 | Sale | $190.00 | 2,000 | 380,000 | 12,988 | Feb 11, 2019, 09:27 PM |
| Johnston Lori A | SVP, HR | Feb 07, 2019 | Option Exercise | $190.76 | 454 | 86,605 | 16,794 | Feb 11, 2019, 09:25 PM |
| Santos Esteban | EVP, Operations | Jan 30, 2019 | Option Exercise | $192.11 | 142 | 27,280 | 34,700 | Feb 01, 2019, 06:28 PM |
| REESE DAVID M | EVP, Research and Development | Jan 30, 2019 | Option Exercise | $192.11 | 115 | 22,093 | 30,648 | Feb 01, 2019, 06:25 PM |
| Piacquad David | SVP, Business Development | Jan 30, 2019 | Option Exercise | $192.11 | 162 | 31,122 | 43,998 | Feb 01, 2019, 06:22 PM |
| Patton Cynthia M | SVP & CCO | Jan 30, 2019 | Option Exercise | $192.11 | 117 | 22,477 | 24,101 | Feb 01, 2019, 06:20 PM |
| Meline David W | EVP & CFO | Jan 30, 2019 | Option Exercise | $192.11 | 528 | 101,434 | 46,660 | Feb 01, 2019, 06:18 PM |
| Bradway Robert A | Chairman, CEO and President | Jan 30, 2019 | Option Exercise | $192.11 | 1,625 | 312,179 | 430,399 | Feb 01, 2019, 06:14 PM |
| Jacks Tyler | Director | Dec 06, 2018 | Option Exercise | $82.60 | 20,000 | 1,652,000 | 28,979 | Dec 10, 2018, 08:46 PM |
| Jacks Tyler | Director | Dec 06, 2018 | Sale | $195.41 | 20,000 | 3,908,240 | 8,979 | Dec 10, 2018, 08:46 PM |
| Piacquad David | SVP, Business Development | Nov 30, 2018 | Option Exercise | $202.37 | 4,109 | 831,538 | 41,019 | Dec 03, 2018, 08:13 PM |
| Piacquad David | SVP, Business Development | Nov 30, 2018 | Option Exercise | $54.69 | 6,500 | 355,485 | 45,128 | Dec 03, 2018, 08:13 PM |
| Patton Cynthia M | SVP & CCO | Nov 29, 2018 | Option Exercise | $54.69 | 1,777 | 97,184 | 23,090 | Dec 03, 2018, 08:11 PM |
| Patton Cynthia M | SVP & CCO | Nov 29, 2018 | Sale | $202.88 | 1,777 | 360,520 | 21,313 | Dec 03, 2018, 08:11 PM |
| HENDERSON REBECCA M | Director | Aug 10, 2018 | Option Exercise | $193.97 | 977 | 189,509 | 15,220 | Aug 14, 2018, 08:29 PM |
| HENDERSON REBECCA M | Director | Aug 10, 2018 | Option Exercise | $63.11 | 3,000 | 189,330 | 16,197 | Aug 14, 2018, 08:29 PM |
| Graham Jonathan P | SVP, Gen. Counsel & Secy. | Aug 06, 2018 | Option Exercise | $197.99 | 6,586 | 1,303,962 | 41,256 | Aug 06, 2018, 08:41 PM |
| Santos Esteban | EVP, Operations | Aug 01, 2018 | Option Exercise | $196.55 | 1,982 | 389,562 | 34,654 | Aug 02, 2018, 06:39 PM |
| Meline David W | EVP & CFO | Aug 01, 2018 | Option Exercise | $196.55 | 7,382 | 1,450,932 | 52,202 | Aug 02, 2018, 06:36 PM |
| Harper Sean E | EVP, Research & Development | Jul 16, 2018 | Sale | $195.71 | 1,525 | 298,458 | 56,082 | Jul 16, 2018, 08:20 PM |
| Harper Sean E | EVP, Research & Development | Jun 12, 2018 | Sale | $184.27 | 1,525 | 281,012 | 57,510 | Jun 12, 2018, 07:07 PM |
| Piacquad David | SVP, Business Development | May 11, 2018 | Option Exercise | $170.77 | 9,860 | 1,683,792 | 41,706 | May 15, 2018, 07:55 PM |
| Piacquad David | SVP, Business Development | May 11, 2018 | Option Exercise | $54.71 | 15,000 | 820,650 | 51,566 | May 15, 2018, 07:55 PM |
| Harper Sean E | EVP, Research & Development | May 14, 2018 | Sale | $174.10 | 1,525 | 265,503 | 59,035 | May 15, 2018, 07:52 PM |
| Santos Esteban | EVP, Operations | May 03, 2018 | Option Exercise | $169.43 | 178 | 30,159 | 36,466 | May 07, 2018, 07:13 PM |
| Piacquad David | SVP, Business Development | May 03, 2018 | Option Exercise | $169.43 | 178 | 30,159 | 36,566 | May 07, 2018, 07:11 PM |
| Patton Cynthia M | SVP & CCO | May 03, 2018 | Option Exercise | $169.43 | 169 | 28,634 | 24,156 | May 07, 2018, 07:09 PM |
| Meline David W | EVP & CFO | May 03, 2018 | Option Exercise | $169.43 | 773 | 130,969 | 59,382 | May 07, 2018, 07:06 PM |
| HOOPER ANTHONY C | EVP, Global Commercial Ops. | May 03, 2018 | Option Exercise | $169.43 | 883 | 149,607 | 215,147 | May 07, 2018, 07:01 PM |
| Harper Sean E | EVP, Research & Development | May 03, 2018 | Option Exercise | $169.43 | 736 | 124,700 | 60,560 | May 07, 2018, 06:58 PM |
| Graham Jonathan P | SVP, Gen. Counsel & Secy. | May 03, 2018 | Option Exercise | $169.43 | 390 | 66,078 | 47,366 | May 07, 2018, 06:53 PM |
| Bradway Robert A | Chairman, CEO and President | May 03, 2018 | Option Exercise | $169.43 | 2,312 | 391,722 | 431,101 | May 07, 2018, 06:50 PM |
| de Carbonnel Francois | Director | Apr 27, 2018 | Option Exercise | $175.37 | 260 | 45,596 | 16,426 | May 01, 2018, 06:28 PM |
| Piacquad David | SVP, Business Development | Apr 25, 2018 | Option Exercise | $171.94 | 217 | 37,311 | 35,787 | Apr 26, 2018, 07:17 PM |
| Harper Sean E | EVP, Research & Development | Apr 12, 2018 | Sale | $172.68 | 1,525 | 263,337 | 56,788 | Apr 16, 2018, 07:03 PM |
| Santos Esteban | EVP, Operations | Mar 23, 2018 | Option Exercise | $176.08 | 1,634 | 287,715 | 33,489 | Mar 27, 2018, 07:51 PM |
| Piacquad David | SVP, Business Development | Mar 23, 2018 | Option Exercise | $176.08 | 1,519 | 267,466 | 36,004 | Mar 27, 2018, 07:48 PM |
| Patton Cynthia M | SVP & CCO | Mar 23, 2018 | Option Exercise | $176.08 | 1,257 | 221,333 | 23,424 | Mar 27, 2018, 07:46 PM |
| Meline David W | EVP & CFO | Mar 23, 2018 | Option Exercise | $176.08 | 7,549 | 1,329,228 | 55,647 | Mar 27, 2018, 07:44 PM |
| HOOPER ANTHONY C | EVP, Global Commercial Ops. | Mar 23, 2018 | Option Exercise | $176.08 | 8,807 | 1,550,737 | 211,522 | Mar 27, 2018, 07:42 PM |
| Harper Sean E | EVP, Research & Development | Mar 23, 2018 | Option Exercise | $176.08 | 7,549 | 1,329,228 | 58,313 | Mar 27, 2018, 07:40 PM |
| Bradway Robert A | Chairman, CEO and President | Mar 23, 2018 | Option Exercise | $176.08 | 25,666 | 4,519,269 | 419,326 | Mar 27, 2018, 07:38 PM |
| Harper Sean E | EVP, Research & Development | Mar 16, 2018 | Sale | $189.75 | 1,525 | 289,369 | 65,682 | Mar 19, 2018, 08:52 PM |
| Harper Sean E | EVP, Research & Development | Feb 14, 2018 | Sale | $174.18 | 1,525 | 265,624 | 52,089 | Feb 15, 2018, 08:57 PM |
| Johnston Lori A | SVP, HR | Feb 07, 2018 | Option Exercise | $176.65 | 441 | 77,903 | 15,017 | Feb 07, 2018, 07:31 PM |
| Santos Esteban | EVP, Operations | Jan 31, 2018 | Option Exercise | $191.27 | 141 | 26,969 | 31,453 | Feb 01, 2018, 08:44 PM |
| Santos Esteban | EVP, Operations | Jan 30, 2018 | Option Exercise | $198.00 | 133 | 26,334 | 31,594 | Feb 01, 2018, 08:44 PM |
| Patton Cynthia M | SVP & CCO | Jan 30, 2018 | Option Exercise | $198.00 | 109 | 21,582 | 21,245 | Feb 01, 2018, 08:42 PM |
| Patton Cynthia M | SVP & CCO | Jan 31, 2018 | Option Exercise | $191.27 | 132 | 25,248 | 21,113 | Feb 01, 2018, 08:42 PM |
| HOOPER ANTHONY C | EVP, Global Commercial Ops. | Jan 31, 2018 | Option Exercise | $191.27 | 651 | 124,517 | 202,483 | Feb 01, 2018, 08:38 PM |
| HOOPER ANTHONY C | EVP, Global Commercial Ops. | Jan 30, 2018 | Option Exercise | $198.00 | 575 | 113,850 | 203,134 | Feb 01, 2018, 08:38 PM |
| Harper Sean E | EVP, Research & Development | Jan 31, 2018 | Option Exercise | $191.27 | 606 | 115,910 | 53,614 | Feb 01, 2018, 08:35 PM |
| Harper Sean E | EVP, Research & Development | Jan 30, 2018 | Option Exercise | $198.00 | 453 | 89,694 | 54,200 | Feb 01, 2018, 08:35 PM |
| Bradway Robert A | Chairman, CEO and President | Jan 30, 2018 | Option Exercise | $198.00 | 1,533 | 303,534 | 395,598 | Feb 01, 2018, 08:32 PM |
| Bradway Robert A | Chairman, CEO and President | Jan 31, 2018 | Option Exercise | $191.27 | 2,616 | 500,362 | 392,982 | Feb 01, 2018, 08:32 PM |
| Piacquad David | SVP, Business Development | Jan 30, 2018 | Option Exercise | $198.00 | 153 | 30,294 | 33,443 | Jan 30, 2018, 08:38 PM |
| Meline David W | EVP & CFO | Jan 30, 2018 | Option Exercise | $198.00 | 496 | 98,208 | 47,795 | Jan 30, 2018, 08:34 PM |
| Harper Sean E | EVP, Research & Development | Jan 16, 2018 | Sale | $185.62 | 1,525 | 283,070 | 54,673 | Jan 17, 2018, 08:19 PM |
| Harper Sean E | EVP, Research & Development | Dec 12, 2017 | Sale | $176.83 | 1,525 | 269,666 | 56,106 | Dec 12, 2017, 08:24 PM |
| Harper Sean E | EVP, Research & Development | Nov 13, 2017 | Sale | $171.58 | 1,525 | 261,660 | 57,631 | Nov 14, 2017, 07:27 PM |
| de Carbonnel Francois | Director | Nov 08, 2017 | Sale | $173.60 | 4,000 | 694,420 | 15,528 | Nov 08, 2017, 05:39 PM |
| Harper Sean E | EVP, Research & Development | Oct 09, 2017 | Sale | $185.95 | 1,525 | 283,574 | 59,156 | Oct 10, 2017, 08:29 PM |
| Graham Jonathan P | SVP, Gen. Counsel & Secy. | Aug 04, 2017 | Option Exercise | $174.18 | 6,747 | 1,175,192 | 44,165 | Aug 04, 2017, 05:51 PM |
| Santos Esteban | EVP, Operations | Aug 02, 2017 | Option Exercise | $174.13 | 639 | 111,269 | 31,478 | Aug 02, 2017, 07:44 PM |
| Meline David W | EVP & CFO | Aug 01, 2017 | Option Exercise | $174.51 | 7,562 | 1,319,645 | 47,920 | Aug 01, 2017, 08:50 PM |
| BALTIMORE DAVID | Director | May 31, 2017 | Sale | $153.93 | 3,700 | 569,541 | 31,159 | Jun 02, 2017, 07:21 PM |
| Patton Cynthia M | SVP & CCO | May 24, 2017 | Sale | $154.40 | 2,922 | 451,163 | 21,292 | May 24, 2017, 07:35 PM |
| de Carbonnel Francois | Director | May 01, 2017 | Option Exercise | $163.32 | 343 | 56,019 | 19,498 | May 03, 2017, 08:19 PM |
| Santos Esteban | EVP, Operations | Apr 26, 2017 | Option Exercise | $164.70 | 191 | 31,458 | 14,616 | Apr 26, 2017, 08:14 PM |
| Such Annette Louise | VP, Finance and CAO | Apr 26, 2017 | Option Exercise | $164.70 | 44 | 7,247 | 7,863 | Apr 26, 2017, 08:12 PM |
| Such Annette Louise | VP, Finance and CAO | Apr 25, 2017 | Option Exercise | $163.14 | 40 | 6,526 | 7,907 | Apr 26, 2017, 08:12 PM |
| Piacquad David | SVP, Business Development | Apr 26, 2017 | Option Exercise | $164.70 | 2,783 | 458,360 | 35,169 | Apr 26, 2017, 08:10 PM |
| Piacquad David | SVP, Business Development | Apr 25, 2017 | Option Exercise | $163.14 | 215 | 35,075 | 35,332 | Apr 26, 2017, 08:10 PM |
| Such Annette Louise | VP, Finance and CAO | Apr 24, 2017 | Option Exercise | $160.41 | 194 | 31,120 | 8,103 | Apr 25, 2017, 08:22 PM |
| Such Annette Louise | VP, Finance and CAO | Mar 24, 2017 | Option Exercise | $166.04 | 533 | 88,499 | 8,141 | Mar 28, 2017, 07:05 PM |
| Santos Esteban | EVP, Operations | Mar 24, 2017 | Option Exercise | $166.04 | 2,313 | 384,051 | 30,891 | Mar 28, 2017, 07:03 PM |
| Piacquad David | SVP, Business Development | Mar 24, 2017 | Option Exercise | $166.04 | 2,528 | 419,749 | 35,547 | Mar 28, 2017, 07:01 PM |
| Patton Cynthia M | SVP & CCO | Mar 24, 2017 | Option Exercise | $166.04 | 1,893 | 314,314 | 23,576 | Mar 28, 2017, 06:59 PM |
| MCNAMEE BRIAN M | EVP | Mar 24, 2017 | Option Exercise | $166.04 | 11,219 | 1,862,803 | 99,072 | Mar 28, 2017, 06:57 PM |
| HOOPER ANTHONY C | EVP, Global Commercial Ops. | Mar 24, 2017 | Option Exercise | $166.04 | 12,128 | 2,013,733 | 198,482 | Mar 28, 2017, 06:55 PM |
| Harper Sean E | EVP, Research & Development | Mar 24, 2017 | Option Exercise | $166.04 | 12,128 | 2,013,733 | 55,945 | Mar 28, 2017, 06:54 PM |
| Bradway Robert A | Chairman, CEO and President | Mar 24, 2017 | Option Exercise | $166.04 | 36,384 | 6,041,199 | 381,482 | Mar 28, 2017, 06:51 PM |
| Bradway Robert A | Chairman, CEO and President | Jan 31, 2017 | Option Exercise | $154.43 | 2,780 | 429,315 | 347,952 | Feb 02, 2017, 07:12 PM |
| HOOPER ANTHONY C | EVP, Global Commercial Ops. | Jan 31, 2017 | Option Exercise | $154.43 | 668 | 103,159 | 187,305 | Feb 02, 2017, 07:03 PM |
| Harper Sean E | EVP, Research & Development | Jan 31, 2017 | Option Exercise | $154.43 | 668 | 103,159 | 44,774 | Feb 02, 2017, 06:59 PM |
| Patton Cynthia M | SVP & CCO | Jan 31, 2017 | Option Exercise | $154.43 | 136 | 21,002 | 20,421 | Feb 02, 2017, 06:53 PM |
| MCNAMEE BRIAN M | EVP | Jan 31, 2017 | Option Exercise | $154.43 | 585 | 90,342 | 88,549 | Feb 02, 2017, 06:47 PM |
| Santos Esteban | EVP, Operations | Jan 31, 2017 | Option Exercise | $154.43 | 152 | 23,473 | 28,071 | Feb 01, 2017, 04:57 PM |
| Santos Esteban | EVP, Operations | Jan 30, 2017 | Option Exercise | $157.16 | 140 | 22,002 | 28,223 | Feb 01, 2017, 04:57 PM |
| MCNAMEE BRIAN M | EVP | Jan 30, 2017 | Option Exercise | $157.16 | 449 | 70,565 | 89,134 | Jan 31, 2017, 08:37 PM |
| MCNAMEE BRIAN M | EVP | Jan 28, 2017 | Option Exercise | $157.16 | 582 | 91,467 | 89,583 | Jan 31, 2017, 08:37 PM |
| Piacquad David | SVP, Business Development | Jan 30, 2017 | Option Exercise | $157.16 | 160 | 25,146 | 32,354 | Jan 31, 2017, 07:27 PM |
| Meline David W | EVP & CFO | Jan 30, 2017 | Option Exercise | $157.16 | 529 | 83,138 | 50,690 | Jan 31, 2017, 07:21 PM |
| Bradway Robert A | Chairman, CEO and President | Jan 30, 2017 | Option Exercise | $157.16 | 2,417 | 379,856 | 350,732 | Jan 31, 2017, 07:15 PM |
| Bradway Robert A | Chairman, CEO and President | Jan 28, 2017 | Option Exercise | $157.16 | 2,673 | 420,089 | 353,149 | Jan 31, 2017, 07:15 PM |
| HOOPER ANTHONY C | EVP, Global Commercial Ops. | Jan 30, 2017 | Option Exercise | $157.16 | 598 | 93,982 | 187,973 | Jan 31, 2017, 07:10 PM |
| HOOPER ANTHONY C | EVP, Global Commercial Ops. | Jan 28, 2017 | Option Exercise | $157.16 | 1,053 | 165,489 | 188,571 | Jan 31, 2017, 07:10 PM |
| Harper Sean E | EVP, Research & Development | Jan 30, 2017 | Option Exercise | $157.16 | 513 | 80,623 | 45,442 | Jan 31, 2017, 07:08 PM |
| Harper Sean E | EVP, Research & Development | Jan 28, 2017 | Option Exercise | $157.16 | 1,056 | 165,961 | 45,955 | Jan 31, 2017, 07:08 PM |
| Patton Cynthia M | SVP & CCO | Jan 28, 2017 | Option Exercise | $157.16 | 279 | 43,848 | 20,670 | Jan 31, 2017, 07:01 PM |
| Patton Cynthia M | SVP & CCO | Jan 30, 2017 | Option Exercise | $157.16 | 113 | 17,759 | 20,557 | Jan 31, 2017, 07:01 PM |
| Patton Cynthia M | SVP & CCO | Oct 26, 2016 | Option Exercise | $157.90 | 1,043 | 164,684 | 20,924 | Oct 26, 2016, 08:59 PM |
| MCNAMEE BRIAN M | EVP | Oct 25, 2016 | Option Exercise | $158.76 | 2,109 | 334,825 | 90,078 | Oct 26, 2016, 08:56 PM |
| de Carbonnel Francois | Director | Sep 09, 2016 | Option Exercise | $170.97 | 2,604 | 445,206 | 18,567 | Sep 13, 2016, 06:21 PM |
| de Carbonnel Francois | Director | Sep 09, 2016 | Option Exercise | $71.64 | 5,000 | 358,200 | 21,171 | Sep 13, 2016, 06:21 PM |
| Graham Jonathan P | SVP, Gen. Counsel & Secy. | Aug 04, 2016 | Option Exercise | $173.43 | 6,570 | 1,139,435 | 46,748 | Aug 04, 2016, 09:10 PM |
| Meline David W | EVP & CFO | Aug 01, 2016 | Option Exercise | $172.03 | 6,766 | 1,163,955 | 50,741 | Aug 03, 2016, 08:22 PM |
| Such Annette Louise | VP, Finance and CAO | Aug 01, 2016 | Option Exercise | $172.03 | 258 | 44,384 | 10,183 | Aug 03, 2016, 08:14 PM |
| Such Annette Louise | VP, Finance and CAO | Aug 02, 2016 | Sale | $174.59 | 3,000 | 523,758 | 7,183 | Aug 03, 2016, 08:14 PM |
| Balachandran Madhavan | EVP, Operations | May 04, 2016 | Sale | $154.12 | 30,000 | 4,623,630 | 55,996 | May 05, 2016, 08:16 PM |
| de Carbonnel Francois | Director | May 03, 2016 | Option Exercise | $158.99 | 307 | 48,810 | 16,159 | May 05, 2016, 07:52 PM |
| Harper Sean E | EVP, Research & Development | Apr 29, 2016 | Sale | $157.99 | 21,875 | 3,456,141 | 42,248 | May 03, 2016, 07:14 PM |
| BALTIMORE DAVID | Director | Apr 29, 2016 | Sale | $157.21 | 3,312 | 520,683 | 32,350 | May 03, 2016, 07:12 PM |
| Patton Cynthia M | SVP & CCO | Apr 27, 2016 | Option Exercise | $162.85 | 230 | 37,456 | 20,878 | Apr 29, 2016, 07:50 PM |
| MCNAMEE BRIAN M | EVP | Apr 27, 2016 | Option Exercise | $162.85 | 818 | 133,211 | 88,408 | Apr 29, 2016, 07:47 PM |
| HOOPER ANTHONY C | EVP, Global Commercial Ops. | Apr 27, 2016 | Option Exercise | $162.85 | 1,659 | 270,168 | 184,196 | Apr 29, 2016, 07:45 PM |
| Harper Sean E | EVP, Research & Development | Apr 27, 2016 | Option Exercise | $162.85 | 1,659 | 270,168 | 64,123 | Apr 29, 2016, 07:43 PM |
| Bradway Robert A | Chairman, CEO and President | Apr 27, 2016 | Option Exercise | $162.85 | 4,012 | 653,354 | 340,875 | Apr 29, 2016, 07:41 PM |
| Balachandran Madhavan | EVP, Operations | Apr 27, 2016 | Option Exercise | $162.85 | 462 | 75,237 | 19,978 | Apr 29, 2016, 07:39 PM |
| Tross Stuart A | SVP, Human Resources | Apr 27, 2016 | Option Exercise | $162.85 | 254 | 41,364 | 23,625 | Apr 28, 2016, 08:50 PM |
| Tross Stuart A | SVP, Human Resources | Apr 26, 2016 | Option Exercise | $163.46 | 181 | 29,586 | 23,879 | Apr 28, 2016, 08:50 PM |
| Piacquad David | SVP, Business Development | Apr 27, 2016 | Option Exercise | $162.85 | 289 | 47,064 | 31,336 | Apr 28, 2016, 08:48 PM |
| Piacquad David | SVP, Business Development | Apr 26, 2016 | Option Exercise | $163.46 | 154 | 25,173 | 31,635 | Apr 28, 2016, 08:48 PM |
| Such Annette Louise | VP, Finance and CAO | Apr 26, 2016 | Option Exercise | $163.46 | 41 | 6,702 | 9,839 | Apr 28, 2016, 08:44 PM |
| Piacquad David | SVP, Business Development | Apr 25, 2016 | Option Exercise | $163.19 | 210 | 34,270 | 31,789 | Apr 26, 2016, 07:42 PM |
| Such Annette Louise | VP, Finance and CAO | Apr 25, 2016 | Option Exercise | $163.19 | 39 | 6,364 | 9,880 | Apr 26, 2016, 07:39 PM |
| BALTIMORE DAVID | Director | Mar 30, 2016 | Option Exercise | $149.49 | 1,688 | 252,339 | 35,662 | Mar 31, 2016, 06:01 PM |
| BALTIMORE DAVID | Director | Mar 30, 2016 | Option Exercise | $50.44 | 5,000 | 252,200 | 37,350 | Mar 31, 2016, 06:01 PM |
| Tross Stuart A | SVP, Human Resources | Mar 25, 2016 | Option Exercise | $149.24 | 2,703 | 403,396 | 24,060 | Mar 29, 2016, 05:35 PM |
| Such Annette Louise | VP, Finance and CAO | Mar 25, 2016 | Option Exercise | $149.24 | 729 | 108,796 | 9,919 | Mar 29, 2016, 05:30 PM |
| Piacquad David | SVP, Business Development | Mar 25, 2016 | Option Exercise | $149.24 | 2,307 | 344,297 | 31,999 | Mar 29, 2016, 05:26 PM |
| Patton Cynthia M | SVP & CCO | Mar 25, 2016 | Option Exercise | $149.24 | 6,354 | 948,271 | 21,108 | Mar 29, 2016, 05:22 PM |
| MCNAMEE BRIAN M | EVP | Mar 25, 2016 | Option Exercise | $149.24 | 14,016 | 2,091,748 | 89,226 | Mar 29, 2016, 05:17 PM |
| HOOPER ANTHONY C | EVP, Global Commercial Ops. | Mar 25, 2016 | Option Exercise | $149.24 | 23,785 | 3,549,674 | 185,855 | Mar 29, 2016, 05:13 PM |
| Harper Sean E | EVP, Research & Development | Mar 25, 2016 | Option Exercise | $149.24 | 23,785 | 3,549,674 | 65,782 | Mar 29, 2016, 05:09 PM |
| Bradway Robert A | Chairman, CEO and President | Mar 25, 2016 | Option Exercise | $149.24 | 59,464 | 8,874,408 | 344,887 | Mar 29, 2016, 05:08 PM |
| Balachandran Madhavan | EVP, Operations | Mar 25, 2016 | Option Exercise | $149.24 | 23,785 | 3,549,674 | 42,236 | Mar 29, 2016, 05:05 PM |
| HERRINGER FRANK C | Director | Mar 14, 2016 | Option Exercise | $144.57 | 1,745 | 252,275 | 28,863 | Mar 16, 2016, 06:48 PM |
| HERRINGER FRANK C | Director | Mar 14, 2016 | Option Exercise | $50.44 | 5,000 | 252,200 | 30,608 | Mar 16, 2016, 06:48 PM |
| COFFMAN VANCE D | Director | Mar 09, 2016 | Option Exercise | $144.63 | 1,744 | 252,235 | 41,703 | Mar 10, 2016, 06:55 PM |
| COFFMAN VANCE D | Director | Mar 09, 2016 | Option Exercise | $50.44 | 5,000 | 252,200 | 43,447 | Mar 10, 2016, 06:55 PM |
| Bradway Robert A | Chairman, CEO and President | Mar 02, 2016 | Option Exercise | $148.39 | 43,799 | 6,499,334 | 403,303 | Mar 04, 2016, 06:07 PM |
| Bradway Robert A | Chairman, CEO and President | Mar 02, 2016 | Option Exercise | $50.44 | 84,000 | 4,236,960 | 447,102 | Mar 04, 2016, 06:07 PM |
| Bradway Robert A | Chairman, CEO and President | Mar 02, 2016 | Sale | $146.48 | 20,000 | 2,929,560 | 383,102 | Mar 04, 2016, 06:07 PM |
| Tross Stuart A | SVP, Human Resources | Jan 31, 2016 | Option Exercise | $152.73 | 251 | 38,335 | 20,478 | Feb 01, 2016, 08:41 PM |
| Patton Cynthia M | SVP & CCO | Jan 31, 2016 | Option Exercise | $152.73 | 139 | 21,229 | 14,611 | Feb 01, 2016, 08:35 PM |
| Patton Cynthia M | SVP & CCO | Jan 28, 2016 | Option Exercise | $150.47 | 308 | 46,345 | 14,721 | Feb 01, 2016, 08:35 PM |
| MCNAMEE BRIAN M | EVP | Jan 31, 2016 | Option Exercise | $152.73 | 570 | 87,056 | 76,082 | Feb 01, 2016, 08:32 PM |
| MCNAMEE BRIAN M | EVP | Jan 28, 2016 | Option Exercise | $150.47 | 551 | 82,909 | 76,567 | Feb 01, 2016, 08:32 PM |
| HOOPER ANTHONY C | EVP, Global Commercial Ops. | Jan 31, 2016 | Option Exercise | $152.73 | 651 | 99,427 | 163,962 | Feb 01, 2016, 08:30 PM |
| HOOPER ANTHONY C | EVP, Global Commercial Ops. | Jan 28, 2016 | Option Exercise | $150.47 | 995 | 149,718 | 164,339 | Feb 01, 2016, 08:30 PM |
| Harper Sean E | EVP, Research & Development | Jan 28, 2016 | Option Exercise | $150.47 | 999 | 150,320 | 44,281 | Feb 01, 2016, 08:29 PM |
| Harper Sean E | EVP, Research & Development | Jan 31, 2016 | Option Exercise | $152.73 | 651 | 99,427 | 43,894 | Feb 01, 2016, 08:29 PM |
| Bradway Robert A | Chairman, CEO and President | Jan 31, 2016 | Option Exercise | $152.73 | 2,691 | 410,996 | 269,927 | Feb 01, 2016, 08:27 PM |
| Bradway Robert A | Chairman, CEO and President | Jan 28, 2016 | Option Exercise | $150.47 | 2,453 | 369,103 | 271,865 | Feb 01, 2016, 08:27 PM |
| Balachandran Madhavan | EVP, Operations | Jan 31, 2016 | Option Exercise | $152.73 | 570 | 87,056 | 22,783 | Feb 01, 2016, 08:24 PM |
| Balachandran Madhavan | EVP, Operations | Jan 28, 2016 | Option Exercise | $150.47 | 925 | 139,185 | 23,353 | Feb 01, 2016, 08:24 PM |
| Tross Stuart A | SVP, Human Resources | Oct 25, 2015 | Option Exercise | $155.75 | 569 | 88,622 | 20,696 | Oct 27, 2015, 06:16 PM |
| Patton Cynthia M | SVP & CCO | Oct 26, 2015 | Option Exercise | $155.75 | 987 | 153,725 | 15,662 | Oct 27, 2015, 06:13 PM |
| MCNAMEE BRIAN M | EVP | Oct 25, 2015 | Option Exercise | $155.75 | 1,999 | 311,344 | 77,118 | Oct 27, 2015, 06:11 PM |
| de Carbonnel Francois | Director | Aug 31, 2015 | Sale | $153.84 | 5,000 | 769,190 | 15,150 | Sep 02, 2015, 07:46 PM |
| Hassan Fred | Director | Aug 19, 2015 | Buy | $166.63 | 3,010 | 501,563 | 3,582 | Aug 20, 2015, 05:58 PM |
| Such Annette Louise | CAO | Jul 31, 2015 | Option Exercise | $171.69 | 1,631 | 280,026 | 8,641 | Aug 04, 2015, 06:44 PM |
| Meline David W | EVP & CFO | Aug 01, 2015 | Option Exercise | $176.59 | 7,196 | 1,270,742 | 51,934 | Aug 04, 2015, 06:41 PM |
| Balachandran Madhavan | EVP, Operations | Jul 31, 2015 | Option Exercise | $171.69 | 4,845 | 831,838 | 28,716 | Aug 04, 2015, 06:36 PM |
| PELHAM JUDITH C | Director | Jul 31, 2015 | Sale | $180.40 | 5,035 | 908,314 | 11,890 | Aug 04, 2015, 06:31 PM |
| Patton Cynthia M | SVP & CCO | Jun 02, 2015 | Sale | $157.06 | 4,530 | 711,482 | 16,571 | Jun 03, 2015, 07:16 PM |
| Balachandran Madhavan | EVP, Operations | May 07, 2015 | Option Exercise | $55.72 | 21,750 | 1,211,947 | 55,144 | May 11, 2015, 04:56 PM |
| Balachandran Madhavan | EVP, Operations | May 07, 2015 | Sale | $157.87 | 21,750 | 3,433,691 | 49,144 | May 11, 2015, 04:56 PM |
| Tross Stuart A | SVP, Human Resources | Apr 27, 2015 | Option Exercise | $167.91 | 242 | 40,634 | 21,187 | Apr 28, 2015, 08:18 PM |
| Tross Stuart A | SVP, Human Resources | Apr 26, 2015 | Option Exercise | $167.91 | 176 | 29,552 | 21,429 | Apr 28, 2015, 08:18 PM |
| Tross Stuart A | SVP, Human Resources | Apr 25, 2015 | Option Exercise | $167.91 | 318 | 53,395 | 21,605 | Apr 28, 2015, 08:18 PM |
| Such Annette Louise | CAO | Apr 26, 2015 | Option Exercise | $167.91 | 40 | 6,716 | 10,230 | Apr 28, 2015, 08:16 PM |
| SCOTT DAVID J | SVP, Gen. Counsel & Secy. | Apr 27, 2015 | Option Exercise | $167.91 | 1,069 | 179,496 | 93,949 | Apr 28, 2015, 08:14 PM |
| SCOTT DAVID J | SVP, Gen. Counsel & Secy. | Apr 25, 2015 | Option Exercise | $167.91 | 1,898 | 318,693 | 95,018 | Apr 28, 2015, 08:14 PM |
| Piacquad David | SVP, Business Development | Apr 25, 2015 | Option Exercise | $167.91 | 330 | 55,410 | 31,706 | Apr 28, 2015, 08:10 PM |
| Piacquad David | SVP, Business Development | Apr 27, 2015 | Option Exercise | $167.91 | 274 | 46,007 | 28,784 | Apr 28, 2015, 08:10 PM |
| Piacquad David | SVP, Business Development | Apr 26, 2015 | Option Exercise | $167.91 | 2,648 | 444,626 | 31,555 | Apr 28, 2015, 08:10 PM |
| Patton Cynthia M | SVP & CCO | Apr 25, 2015 | Option Exercise | $167.91 | 266 | 44,664 | 21,320 | Apr 28, 2015, 08:06 PM |
| Patton Cynthia M | SVP & CCO | Apr 27, 2015 | Option Exercise | $167.91 | 219 | 36,772 | 21,101 | Apr 28, 2015, 08:06 PM |
| MCNAMEE BRIAN M | EVP | Apr 27, 2015 | Option Exercise | $167.91 | 777 | 130,466 | 78,904 | Apr 28, 2015, 08:03 PM |
| MCNAMEE BRIAN M | EVP | Apr 25, 2015 | Option Exercise | $167.91 | 1,271 | 213,414 | 79,681 | Apr 28, 2015, 08:03 PM |
| Bradway Robert A | Chairman, CEO and President | Apr 27, 2015 | Option Exercise | $167.91 | 3,810 | 639,737 | 274,318 | Apr 28, 2015, 07:59 PM |
| Bradway Robert A | Chairman, CEO and President | Apr 25, 2015 | Option Exercise | $167.91 | 3,726 | 625,633 | 278,128 | Apr 28, 2015, 07:59 PM |
| Harper Sean E | EVP, Research & Development | Apr 27, 2015 | Option Exercise | $167.91 | 1,575 | 264,458 | 45,280 | Apr 28, 2015, 07:58 PM |
| Harper Sean E | EVP, Research & Development | Apr 25, 2015 | Option Exercise | $167.91 | 1,065 | 178,824 | 46,855 | Apr 28, 2015, 07:58 PM |
| HOOPER ANTHONY C | EVP, Global Commercial Ops. | Apr 27, 2015 | Option Exercise | $167.91 | 1,575 | 264,458 | 165,334 | Apr 28, 2015, 07:56 PM |
| Balachandran Madhavan | EVP, Operations | Apr 25, 2015 | Option Exercise | $167.91 | 763 | 128,115 | 35,036 | Apr 28, 2015, 07:38 PM |
| Balachandran Madhavan | EVP, Operations | Apr 27, 2015 | Option Exercise | $167.91 | 438 | 73,545 | 33,831 | Apr 28, 2015, 07:38 PM |
| de Carbonnel Francois | Director | Apr 24, 2015 | Option Exercise | $167.19 | 228 | 38,119 | 20,139 | Apr 28, 2015, 06:54 PM |
| Tross Stuart A | SVP, Human Resources | Apr 23, 2015 | Sale | $169.31 | 3,012 | 509,965 | 21,923 | Apr 24, 2015, 04:53 PM |
| Harper Sean E | EVP, Research & Development | Apr 22, 2015 | Sale | $171.58 | 28,000 | 4,804,240 | 47,920 | Apr 23, 2015, 05:04 PM |
| Tross Stuart A | SVP, Human Resources | Mar 27, 2015 | Option Exercise | $160.55 | 3,711 | 595,801 | 24,935 | Mar 31, 2015, 07:05 PM |
| SCOTT DAVID J | SVP, Gen. Counsel & Secy. | Mar 27, 2015 | Option Exercise | $160.55 | 20,314 | 3,261,413 | 96,916 | Mar 31, 2015, 07:02 PM |
| Piacquad David | SVP, Business Development | Mar 27, 2015 | Option Exercise | $160.55 | 4,402 | 706,741 | 32,036 | Mar 31, 2015, 06:59 PM |
| Patton Cynthia M | SVP & CCO | Mar 27, 2015 | Option Exercise | $160.55 | 3,500 | 561,925 | 21,586 | Mar 31, 2015, 06:57 PM |
| MCNAMEE BRIAN M | EVP | Mar 27, 2015 | Option Exercise | $160.55 | 14,517 | 2,330,704 | 80,952 | Mar 31, 2015, 06:54 PM |
| HOOPER ANTHONY C | EVP, Global Commercial Ops. | Mar 27, 2015 | Option Exercise | $160.55 | 28,624 | 4,595,583 | 166,909 | Mar 31, 2015, 06:49 PM |
| Harper Sean E | EVP, Research & Development | Mar 27, 2015 | Option Exercise | $160.55 | 28,624 | 4,595,583 | 75,920 | Mar 31, 2015, 06:47 PM |
| Bradway Robert A | Chairman, CEO and President | Mar 27, 2015 | Option Exercise | $160.55 | 69,253 | 11,118,569 | 281,854 | Mar 31, 2015, 06:45 PM |
| Balachandran Madhavan | EVP, Operations | Mar 27, 2015 | Option Exercise | $160.55 | 8,311 | 1,334,331 | 43,413 | Mar 31, 2015, 06:43 PM |
| HOOPER ANTHONY C | EVP, Global Commercial Ops. | Mar 11, 2015 | Option Exercise | $153.58 | 27,540 | 4,229,593 | 195,148 | Mar 13, 2015, 06:32 PM |
| Tross Stuart A | SVP, Human Resources | Mar 03, 2015 | Sale | $157.74 | 4,415 | 696,427 | 20,237 | Mar 04, 2015, 08:25 PM |
| BALTIMORE DAVID | Director | Mar 02, 2015 | Sale | $158.76 | 3,647 | 579,012 | 31,159 | Mar 03, 2015, 08:55 PM |
| HOOPER ANTHONY C | EVP, Global Commercial Ops. | Mar 02, 2015 | Option Exercise | $157.72 | 3,215 | 507,070 | 115,334 | Mar 03, 2015, 08:52 PM |
| BALTIMORE DAVID | Director | Feb 19, 2015 | Option Exercise | $155.78 | 1,353 | 210,770 | 34,806 | Feb 23, 2015, 04:13 PM |
| BALTIMORE DAVID | Director | Feb 19, 2015 | Option Exercise | $42.13 | 5,000 | 210,650 | 36,159 | Feb 23, 2015, 04:13 PM |
| Bradway Robert A | Chairman, CEO and President | Feb 11, 2015 | Option Exercise | $152.57 | 40,539 | 6,185,036 | 218,102 | Feb 12, 2015, 09:09 PM |
| Bradway Robert A | Chairman, CEO and President | Feb 11, 2015 | Option Exercise | $42.13 | 84,000 | 3,538,920 | 258,641 | Feb 12, 2015, 09:09 PM |
| Bradway Robert A | Chairman, CEO and President | Feb 11, 2015 | Sale | $152.69 | 22,000 | 3,359,114 | 218,102 | Feb 12, 2015, 09:09 PM |
| COFFMAN VANCE D | Director | Feb 06, 2015 | Option Exercise | $153.36 | 1,374 | 210,717 | 37,086 | Feb 06, 2015, 06:23 PM |
| COFFMAN VANCE D | Director | Feb 06, 2015 | Option Exercise | $42.13 | 5,000 | 210,650 | 38,460 | Feb 06, 2015, 06:23 PM |
| HERRINGER FRANK C | Director | Feb 05, 2015 | Option Exercise | $151.45 | 1,391 | 210,667 | 24,058 | Feb 05, 2015, 08:11 PM |
| HERRINGER FRANK C | Director | Feb 05, 2015 | Option Exercise | $42.13 | 5,000 | 210,650 | 25,449 | Feb 05, 2015, 08:11 PM |
| HERRINGER FRANK C | Director | Feb 05, 2015 | Buy | $152.29 | 1,500 | 228,435 | 2,000 | Feb 05, 2015, 08:11 PM |
| HERRINGER FRANK C | Director | Feb 05, 2015 | Buy | $152.29 | 1,500 | 228,435 | 2,000 | Feb 05, 2015, 08:11 PM |
| SCOTT DAVID J | SVP, Gen. Counsel & Secy. | Jan 28, 2015 | Option Exercise | $158.89 | 649 | 103,120 | 75,607 | Jan 30, 2015, 05:08 PM |
| Patton Cynthia M | SVP & CCO | Jan 28, 2015 | Option Exercise | $158.89 | 294 | 46,714 | 16,530 | Jan 30, 2015, 05:05 PM |
| MCNAMEE BRIAN M | EVP | Jan 28, 2015 | Option Exercise | $158.89 | 538 | 85,483 | 63,388 | Jan 30, 2015, 05:03 PM |
| HOOPER ANTHONY C | EVP, Global Commercial Ops. | Jan 28, 2015 | Option Exercise | $158.89 | 959 | 152,376 | 113,987 | Jan 30, 2015, 04:58 PM |
| Harper Sean E | EVP, Research & Development | Jan 28, 2015 | Option Exercise | $158.89 | 963 | 153,011 | 45,680 | Jan 30, 2015, 04:56 PM |
| Bradway Robert A | Chairman, CEO and President | Jan 28, 2015 | Option Exercise | $158.89 | 2,418 | 384,196 | 183,344 | Jan 30, 2015, 04:53 PM |
| Balachandran Madhavan | EVP, Operations | Jan 28, 2015 | Option Exercise | $158.89 | 904 | 143,637 | 33,517 | Jan 30, 2015, 04:50 PM |
| SCOTT DAVID J | SVP, Gen. Counsel & Secy. | Dec 31, 2014 | Option Exercise | $160.63 | 11,522 | 1,850,779 | 76,252 | Jan 05, 2015, 04:41 PM |
| MCNAMEE BRIAN M | EVP | Dec 31, 2014 | Option Exercise | $160.63 | 11,522 | 1,850,779 | 63,906 | Jan 05, 2015, 04:31 PM |
| Harper Sean E | EVP, Research & Development | Dec 31, 2014 | Option Exercise | $160.63 | 13,046 | 2,095,579 | 46,608 | Jan 05, 2015, 04:22 PM |
| de Carbonnel Francois | Director | Dec 03, 2014 | Sale | $168.01 | 3,000 | 504,041 | 20,659 | Dec 03, 2014, 05:00 PM |
| Patton Cynthia M | SVP & CCO | Oct 28, 2014 | Option Exercise | $148.20 | 522 | 77,360 | 16,787 | Oct 29, 2014, 07:55 PM |
| MCNAMEE BRIAN M | EVP | Oct 25, 2014 | Option Exercise | $147.26 | 1,962 | 288,924 | 75,393 | Oct 28, 2014, 04:09 PM |
| Patton Cynthia M | SVP & CCO | Oct 26, 2014 | Option Exercise | $147.26 | 968 | 142,548 | 17,344 | Oct 28, 2014, 04:06 PM |
| COFFMAN VANCE D | Director | Sep 05, 2014 | Option Exercise | $138.01 | 8,230 | 1,135,822 | 33,393 | Sep 09, 2014, 06:54 PM |
| COFFMAN VANCE D | Director | Sep 05, 2014 | Option Exercise | $56.79 | 20,000 | 1,135,800 | 41,623 | Sep 09, 2014, 06:54 PM |
| Tross Stuart A | SVP, Human Resources | Sep 01, 2014 | Option Exercise | $139.38 | 7,292 | 1,016,359 | 23,022 | Sep 02, 2014, 08:30 PM |
| Harper Sean E | EVP, Research & Development | Aug 05, 2014 | Sale | $127.29 | 14,000 | 1,782,130 | 59,503 | Aug 07, 2014, 04:22 PM |
| Patton Cynthia M | SVP & CCO | Aug 05, 2014 | Option Exercise | $55.99 | 2,644 | 148,041 | 20,878 | Aug 07, 2014, 04:20 PM |
| Patton Cynthia M | SVP & CCO | Aug 05, 2014 | Sale | $127.97 | 2,644 | 338,358 | 18,234 | Aug 07, 2014, 04:20 PM |
| de Carbonnel Francois | Director | Aug 05, 2014 | Option Exercise | $128.65 | 2,471 | 317,894 | 22,149 | Aug 07, 2014, 04:17 PM |
| de Carbonnel Francois | Director | Aug 05, 2014 | Option Exercise | $54.69 | 5,000 | 273,450 | 24,620 | Aug 07, 2014, 04:17 PM |
| Balachandran Madhavan | EVP, Operations | Jul 31, 2014 | Option Exercise | $130.01 | 4,758 | 618,588 | 38,773 | Aug 01, 2014, 04:07 PM |
| Michael A Kelly | Acting CFO | Jun 30, 2014 | Option Exercise | $118.59 | 1,919 | 227,574 | 39,177 | Jul 02, 2014, 04:15 PM |
| Dittrich Thomas J.W. | VP, Finance & CAO | May 21, 2014 | Option Exercise | $56.64 | 4,130 | 233,911 | 22,719 | May 22, 2014, 05:15 PM |
| Dittrich Thomas J.W. | VP, Finance & CAO | May 21, 2014 | Sale | $112.83 | 4,130 | 465,984 | 18,589 | May 22, 2014, 05:15 PM |
| Bradway Robert A | Chairman, CEO and President | May 12, 2014 | Buy | $111.77 | 894 | 99,920 | 185,013 | May 12, 2014, 08:33 PM |
| Tross Stuart A | SVP, Human Resources | Apr 26, 2014 | Option Exercise | $111.41 | 137 | 15,263 | 30,375 | Apr 29, 2014, 06:05 PM |
| Tross Stuart A | SVP, Human Resources | Apr 25, 2014 | Option Exercise | $113.72 | 222 | 25,246 | 30,512 | Apr 29, 2014, 06:05 PM |
| Tross Stuart A | SVP, Human Resources | Apr 27, 2014 | Option Exercise | $111.41 | 171 | 19,051 | 30,211 | Apr 29, 2014, 06:05 PM |
| SCOTT DAVID J | SVP, Gen. Counsel & Secy. | Apr 27, 2014 | Option Exercise | $111.41 | 1,048 | 116,758 | 88,638 | Apr 29, 2014, 06:03 PM |
| SCOTT DAVID J | SVP, Gen. Counsel & Secy. | Apr 26, 2014 | Option Exercise | $111.41 | 723 | 80,549 | 89,648 | Apr 29, 2014, 06:03 PM |
| SCOTT DAVID J | SVP, Gen. Counsel & Secy. | Apr 25, 2014 | Option Exercise | $113.72 | 1,842 | 209,472 | 90,371 | Apr 29, 2014, 06:03 PM |
| Piacquad David | SVP, Business Development | Apr 27, 2014 | Option Exercise | $111.41 | 269 | 29,969 | 27,614 | Apr 29, 2014, 05:59 PM |
| Piacquad David | SVP, Business Development | Apr 25, 2014 | Option Exercise | $113.72 | 320 | 36,390 | 26,707 | Apr 29, 2014, 05:59 PM |
| Patton Cynthia M | SVP & CCO | Apr 27, 2014 | Option Exercise | $111.41 | 190 | 21,168 | 18,193 | Apr 29, 2014, 05:56 PM |
| Patton Cynthia M | SVP & CCO | Apr 26, 2014 | Option Exercise | $111.41 | 50 | 5,571 | 18,375 | Apr 29, 2014, 05:56 PM |
| Patton Cynthia M | SVP & CCO | Apr 25, 2014 | Option Exercise | $113.72 | 186 | 21,152 | 18,425 | Apr 29, 2014, 05:56 PM |
| MCNAMEE BRIAN M | EVP | Apr 27, 2014 | Option Exercise | $111.41 | 762 | 84,894 | 77,119 | Apr 29, 2014, 05:54 PM |
| MCNAMEE BRIAN M | EVP | Apr 26, 2014 | Option Exercise | $111.41 | 723 | 80,549 | 77,853 | Apr 29, 2014, 05:54 PM |
| MCNAMEE BRIAN M | EVP | Apr 25, 2014 | Option Exercise | $113.72 | 1,234 | 140,330 | 78,576 | Apr 29, 2014, 05:54 PM |
| Michael A Kelly | Acting CFO | Apr 27, 2014 | Option Exercise | $111.41 | 146 | 16,266 | 43,112 | Apr 29, 2014, 05:48 PM |
| Michael A Kelly | Acting CFO | Apr 26, 2014 | Option Exercise | $111.41 | 116 | 12,924 | 43,252 | Apr 29, 2014, 05:48 PM |
| Michael A Kelly | Acting CFO | Apr 25, 2014 | Option Exercise | $113.72 | 174 | 19,787 | 42,740 | Apr 29, 2014, 05:48 PM |
| Michael A Kelly | Acting CFO | Apr 28, 2014 | Sale | $110.45 | 2,065 | 228,073 | 41,041 | Apr 29, 2014, 05:48 PM |
| HOOPER ANTHONY C | EVP, Global Commercial Ops. | Apr 27, 2014 | Option Exercise | $111.41 | 1,546 | 172,240 | 114,720 | Apr 29, 2014, 05:45 PM |
| Harper Sean E | EVP, Research & Development | Apr 26, 2014 | Option Exercise | $111.41 | 601 | 66,957 | 74,953 | Apr 29, 2014, 05:42 PM |
| Harper Sean E | EVP, Research & Development | Apr 25, 2014 | Option Exercise | $113.72 | 1,034 | 117,586 | 75,554 | Apr 29, 2014, 05:42 PM |
| Harper Sean E | EVP, Research & Development | Apr 27, 2014 | Option Exercise | $111.41 | 1,546 | 172,240 | 73,463 | Apr 29, 2014, 05:42 PM |
| Dittrich Thomas J.W. | VP, Finance & CAO | Apr 27, 2014 | Option Exercise | $111.41 | 265 | 29,524 | 18,599 | Apr 29, 2014, 05:38 PM |
| Dittrich Thomas J.W. | VP, Finance & CAO | Apr 26, 2014 | Option Exercise | $111.41 | 170 | 18,940 | 18,854 | Apr 29, 2014, 05:38 PM |
| Dittrich Thomas J.W. | VP, Finance & CAO | Apr 25, 2014 | Option Exercise | $113.72 | 312 | 35,481 | 18,343 | Apr 29, 2014, 05:38 PM |
| Balachandran Madhavan | EVP, Operations | Apr 25, 2014 | Option Exercise | $113.72 | 740 | 84,153 | 45,623 | Apr 29, 2014, 05:35 PM |
| Balachandran Madhavan | EVP, Operations | Apr 27, 2014 | Option Exercise | $111.41 | 429 | 47,795 | 44,773 | Apr 29, 2014, 05:35 PM |
| Balachandran Madhavan | EVP, Operations | Apr 26, 2014 | Option Exercise | $111.41 | 437 | 48,686 | 45,186 | Apr 29, 2014, 05:35 PM |
| Bradway Robert A | Chairman, CEO and President | Apr 27, 2014 | Option Exercise | $111.41 | 3,741 | 416,785 | 184,254 | Apr 29, 2014, 05:32 PM |
| Bradway Robert A | Chairman, CEO and President | Apr 26, 2014 | Option Exercise | $111.41 | 2,349 | 261,702 | 188,643 | Apr 29, 2014, 05:32 PM |
| Bradway Robert A | Chairman, CEO and President | Apr 25, 2014 | Option Exercise | $113.72 | 3,617 | 411,325 | 190,209 | Apr 29, 2014, 05:32 PM |
| de Carbonnel Francois | Director | Apr 25, 2014 | Option Exercise | $113.72 | 539 | 61,295 | 19,590 | Apr 29, 2014, 05:12 PM |
| Tross Stuart A | SVP, Human Resources | Mar 14, 2014 | Option Exercise | $123.96 | 1,647 | 204,162 | 30,734 | Mar 18, 2014, 04:41 PM |
| SCOTT DAVID J | SVP, Gen. Counsel & Secy. | Mar 14, 2014 | Option Exercise | $123.96 | 14,278 | 1,769,901 | 92,213 | Mar 18, 2014, 04:38 PM |
| Patton Cynthia M | SVP & CCO | Mar 14, 2014 | Option Exercise | $123.96 | 1,377 | 170,693 | 18,611 | Mar 18, 2014, 04:33 PM |
| MCNAMEE BRIAN M | EVP | Mar 14, 2014 | Option Exercise | $123.96 | 9,411 | 1,166,588 | 79,810 | Mar 18, 2014, 04:31 PM |
| Michael A Kelly | Acting CFO | Mar 14, 2014 | Option Exercise | $123.96 | 1,377 | 170,693 | 42,914 | Mar 18, 2014, 04:29 PM |
| Harper Sean E | EVP, Research & Development | Mar 14, 2014 | Option Exercise | $123.96 | 7,683 | 952,385 | 76,588 | Mar 18, 2014, 04:26 PM |
| Dittrich Thomas J.W. | VP, Finance & CAO | Mar 14, 2014 | Option Exercise | $123.96 | 2,316 | 287,091 | 18,655 | Mar 18, 2014, 04:24 PM |
| Bradway Robert A | Chairman, CEO and President | Mar 14, 2014 | Option Exercise | $123.96 | 26,891 | 3,333,408 | 193,826 | Mar 18, 2014, 04:20 PM |
| Balachandran Madhavan | EVP, Operations | Mar 14, 2014 | Option Exercise | $123.96 | 5,763 | 714,381 | 51,623 | Mar 18, 2014, 04:18 PM |
| HOOPER ANTHONY C | EVP, Global Commercial Ops. | Mar 12, 2014 | Option Exercise | $124.27 | 27,540 | 3,422,396 | 116,210 | Mar 14, 2014, 04:11 PM |
| de Carbonnel Francois | Director | Mar 06, 2014 | Option Exercise | $126.19 | 6,021 | 759,790 | 19,343 | Mar 07, 2014, 05:23 PM |
| de Carbonnel Francois | Director | Mar 06, 2014 | Option Exercise | $54.43 | 10,000 | 544,350 | 25,364 | Mar 07, 2014, 05:23 PM |
| de Carbonnel Francois | Director | Mar 06, 2014 | Sale | $126.69 | 1,000 | 126,690 | 18,343 | Mar 07, 2014, 05:23 PM |
| HOOPER ANTHONY C | EVP, Global Commercial Ops. | Mar 02, 2014 | Option Exercise | $124.02 | 7,537 | 934,739 | 90,865 | Mar 04, 2014, 04:31 PM |
| BALTIMORE DAVID | Director | Feb 26, 2014 | Option Exercise | $124.36 | 2,515 | 312,765 | 29,364 | Feb 26, 2014, 08:28 PM |
| BALTIMORE DAVID | Director | Feb 26, 2014 | Option Exercise | $62.55 | 5,000 | 312,750 | 31,879 | Feb 26, 2014, 08:28 PM |
| HERRINGER FRANK C | Director | Feb 25, 2014 | Option Exercise | $125.79 | 2,487 | 312,840 | 20,875 | Feb 26, 2014, 08:21 PM |
| HERRINGER FRANK C | Director | Feb 25, 2014 | Option Exercise | $62.55 | 5,000 | 312,750 | 23,362 | Feb 26, 2014, 08:21 PM |
| HENDERSON REBECCA M | Director | Feb 13, 2014 | Option Exercise | $62.41 | 20,000 | 1,248,160 | 25,549 | Feb 14, 2014, 04:34 PM |
| HENDERSON REBECCA M | Director | Feb 13, 2014 | Sale | $123.53 | 20,000 | 2,470,680 | 5,549 | Feb 14, 2014, 04:34 PM |
| Bradway Robert A | Chairman, CEO and President | Feb 12, 2014 | Option Exercise | $121.24 | 47,135 | 5,714,647 | 168,905 | Feb 14, 2014, 04:19 PM |
| Bradway Robert A | Chairman, CEO and President | Feb 12, 2014 | Option Exercise | $62.55 | 65,000 | 4,065,750 | 216,040 | Feb 14, 2014, 04:19 PM |
| Peacock Jonathan M | EVP & CFO | Oct 28, 2013 | Option Exercise | $116.32 | 13,045 | 1,517,394 | 94,414 | Oct 29, 2013, 06:22 PM |
| Patton Cynthia M | SVP & CCO | Oct 28, 2013 | Option Exercise | $116.32 | 376 | 43,736 | 15,146 | Oct 29, 2013, 06:18 PM |
| Balachandran Madhavan | EVP, Operations | Sep 04, 2013 | Option Exercise | $58.43 | 18,000 | 1,051,740 | 59,133 | Sep 05, 2013, 07:33 PM |
| Balachandran Madhavan | EVP, Operations | Sep 04, 2013 | Sale | $112.76 | 18,000 | 2,029,770 | 34,851 | Sep 05, 2013, 07:33 PM |
| BALTIMORE DAVID | Director | Aug 28, 2013 | Sale | $109.66 | 4,582 | 502,462 | 27,789 | Aug 30, 2013, 05:36 PM |
| Dittrich Thomas J.W. | VP, Finance & CAO | May 22, 2013 | Option Exercise | $54.62 | 6,130 | 334,791 | 22,863 | May 24, 2013, 05:18 PM |
| Dittrich Thomas J.W. | VP, Finance & CAO | May 22, 2013 | Sale | $104.78 | 6,130 | 642,295 | 16,733 | May 24, 2013, 05:18 PM |
| Balachandran Madhavan | EVP, Operations | May 21, 2013 | Option Exercise | $50.44 | 6,000 | 302,640 | 46,956 | May 21, 2013, 08:18 PM |
| Balachandran Madhavan | EVP, Operations | May 21, 2013 | Sale | $103.28 | 6,000 | 619,680 | 34,851 | May 21, 2013, 08:18 PM |
| HENDERSON REBECCA M | Director | May 17, 2013 | Option Exercise | $55.76 | 7,000 | 390,310 | 13,898 | May 20, 2013, 07:15 PM |
| HENDERSON REBECCA M | Director | May 17, 2013 | Sale | $105.72 | 8,421 | 890,297 | 6,898 | May 20, 2013, 07:15 PM |
| Patton Cynthia M | SVP & CCO | May 16, 2013 | Option Exercise | $54.58 | 3,544 | 193,437 | 18,986 | May 17, 2013, 05:42 PM |
| Patton Cynthia M | SVP & CCO | May 16, 2013 | Sale | $105.01 | 3,544 | 372,148 | 15,442 | May 17, 2013, 05:42 PM |
| PELHAM JUDITH C | Director | May 14, 2013 | Option Exercise | $55.47 | 25,000 | 1,386,650 | 48,149 | May 16, 2013, 05:42 PM |
| PELHAM JUDITH C | Director | May 14, 2013 | Sale | $108.25 | 25,000 | 2,706,175 | 23,149 | May 16, 2013, 05:42 PM |
| BIONDI FRANK | Director | May 14, 2013 | Option Exercise | $56.49 | 10,000 | 564,950 | 39,780 | May 16, 2013, 05:38 PM |
| BIONDI FRANK | Director | May 14, 2013 | Sale | $108.43 | 10,000 | 1,084,320 | 29,780 | May 16, 2013, 05:38 PM |
| Harper Sean E | EVP, Research & Development | May 02, 2013 | Option Exercise | $50.44 | 8,000 | 403,520 | 72,180 | May 06, 2013, 05:27 PM |
| Harper Sean E | EVP, Research & Development | May 02, 2013 | Sale | $106.32 | 8,000 | 850,592 | 64,180 | May 06, 2013, 05:27 PM |
| de Carbonnel Francois | Director | Apr 30, 2013 | Option Exercise | $106.67 | 6,593 | 703,275 | 15,337 | May 02, 2013, 06:26 PM |
| de Carbonnel Francois | Director | Apr 30, 2013 | Option Exercise | $54.74 | 10,000 | 547,400 | 21,930 | May 02, 2013, 06:26 PM |
| de Carbonnel Francois | Director | Apr 26, 2013 | Option Exercise | $108.66 | 554 | 60,198 | 11,930 | Apr 30, 2013, 05:49 PM |
| SCOTT DAVID J | SVP, Gen. Counsel & Secy. | Apr 26, 2013 | Option Exercise | $108.66 | 757 | 82,256 | 76,281 | Apr 30, 2013, 05:25 PM |
| SCOTT DAVID J | SVP, Gen. Counsel & Secy. | Apr 28, 2013 | Option Exercise | $108.38 | 744 | 80,635 | 75,537 | Apr 30, 2013, 05:25 PM |
| Patton Cynthia M | SVP & CCO | Apr 26, 2013 | Option Exercise | $108.66 | 50 | 5,433 | 15,491 | Apr 30, 2013, 05:23 PM |
| Patton Cynthia M | SVP & CCO | Apr 28, 2013 | Option Exercise | $108.38 | 49 | 5,311 | 15,442 | Apr 30, 2013, 05:23 PM |
| MCNAMEE BRIAN M | SVP, Human Resources | Apr 28, 2013 | Option Exercise | $108.38 | 711 | 77,058 | 54,643 | Apr 30, 2013, 05:21 PM |
| MCNAMEE BRIAN M | SVP, Human Resources | Apr 26, 2013 | Option Exercise | $108.66 | 723 | 78,561 | 55,354 | Apr 30, 2013, 05:21 PM |
| MCNAMEE BRIAN M | SVP, Human Resources | Apr 29, 2013 | Option Exercise | $50.44 | 10,000 | 504,400 | 64,643 | Apr 30, 2013, 05:21 PM |
| MCNAMEE BRIAN M | SVP, Human Resources | Apr 26, 2013 | Option Exercise | $58.43 | 10,000 | 584,300 | 66,077 | Apr 30, 2013, 05:21 PM |
| MCNAMEE BRIAN M | SVP, Human Resources | Apr 29, 2013 | Sale | $107.02 | 10,000 | 1,070,190 | 54,643 | Apr 30, 2013, 05:21 PM |
| MCNAMEE BRIAN M | SVP, Human Resources | Apr 26, 2013 | Sale | $107.99 | 10,000 | 1,079,870 | 56,077 | Apr 30, 2013, 05:21 PM |
| Harper Sean E | EVP, Research & Development | Apr 28, 2013 | Option Exercise | $108.38 | 588 | 63,727 | 64,180 | Apr 30, 2013, 05:18 PM |
| Harper Sean E | EVP, Research & Development | Apr 26, 2013 | Option Exercise | $108.66 | 601 | 65,305 | 64,768 | Apr 30, 2013, 05:18 PM |
| Dittrich Thomas J.W. | VP, Finance & CAO | Apr 28, 2013 | Option Exercise | $108.38 | 91 | 9,863 | 16,733 | Apr 30, 2013, 05:14 PM |
| Dittrich Thomas J.W. | VP, Finance & CAO | Apr 26, 2013 | Option Exercise | $108.66 | 98 | 10,649 | 16,824 | Apr 30, 2013, 05:14 PM |
| Bradway Robert A | Chairman, President and CEO | Apr 28, 2013 | Option Exercise | $108.38 | 1,566 | 169,723 | 135,379 | Apr 30, 2013, 05:11 PM |
| Bradway Robert A | Chairman, President and CEO | Apr 26, 2013 | Option Exercise | $108.66 | 2,349 | 255,242 | 136,945 | Apr 30, 2013, 05:11 PM |
| Balachandran Madhavan | EVP, Operations | Apr 28, 2013 | Option Exercise | $108.38 | 424 | 45,953 | 41,382 | Apr 30, 2013, 05:08 PM |
| Balachandran Madhavan | EVP, Operations | Apr 26, 2013 | Option Exercise | $108.66 | 437 | 47,484 | 42,244 | Apr 30, 2013, 05:08 PM |
| Peacock Jonathan M | EVP & CFO | Apr 25, 2013 | Option Exercise | $104.93 | 2,721 | 285,515 | 107,312 | Apr 29, 2013, 06:10 PM |
| Patton Cynthia M | SVP & CCO | Apr 25, 2013 | Option Exercise | $104.93 | 185 | 19,412 | 15,541 | Apr 29, 2013, 06:07 PM |
| Harper Sean E | EVP, Research & Development | Apr 25, 2013 | Option Exercise | $104.93 | 1,034 | 108,498 | 65,369 | Apr 29, 2013, 06:04 PM |
| Dittrich Thomas J.W. | VP, Finance & CAO | Apr 25, 2013 | Option Exercise | $104.93 | 179 | 18,782 | 15,980 | Apr 29, 2013, 06:00 PM |
| Bradway Robert A | Chairman, President and CEO | Apr 25, 2013 | Option Exercise | $104.93 | 3,617 | 379,532 | 139,294 | Apr 29, 2013, 05:57 PM |
| Balachandran Madhavan | EVP, Operations | Apr 25, 2013 | Option Exercise | $104.93 | 740 | 77,648 | 43,426 | Apr 29, 2013, 05:54 PM |
| SCOTT DAVID J | SVP, Gen. Counsel & Secy. | Apr 25, 2013 | Option Exercise | $104.93 | 1,929 | 202,410 | 77,038 | Apr 26, 2013, 05:51 PM |
| MCNAMEE BRIAN M | SVP, Human Resources | Apr 25, 2013 | Option Exercise | $104.93 | 1,234 | 129,484 | 56,077 | Apr 26, 2013, 05:33 PM |
| MCNAMEE BRIAN M | SVP, Human Resources | Apr 25, 2013 | Option Exercise | $54.69 | 8,662 | 473,725 | 65,973 | Apr 26, 2013, 05:33 PM |
| MCNAMEE BRIAN M | SVP, Human Resources | Apr 25, 2013 | Sale | $107.95 | 8,662 | 935,028 | 57,311 | Apr 26, 2013, 05:33 PM |
| MCNAMEE BRIAN M | SVP, Human Resources | Apr 24, 2013 | Sale | $105.94 | 6,924 | 733,563 | 58,311 | Apr 26, 2013, 05:33 PM |
| SCOTT DAVID J | SVP, Gen. Counsel & Secy. | Mar 15, 2013 | Option Exercise | $92.18 | 8,647 | 797,080 | 78,967 | Mar 19, 2013, 07:58 PM |
| Patton Cynthia M | SVP & CCO | Mar 15, 2013 | Option Exercise | $92.18 | 569 | 52,450 | 15,726 | Mar 19, 2013, 07:50 PM |
| MCNAMEE BRIAN M | SVP, Human Resources | Mar 15, 2013 | Option Exercise | $92.18 | 8,647 | 797,080 | 65,235 | Mar 19, 2013, 07:48 PM |
| Harper Sean E | EVP, Research & Development | Mar 15, 2013 | Option Exercise | $92.18 | 6,918 | 637,701 | 66,403 | Mar 19, 2013, 07:43 PM |
| Dittrich Thomas J.W. | VP, Finance & CAO | Mar 15, 2013 | Option Exercise | $92.18 | 1,121 | 103,334 | 16,159 | Mar 19, 2013, 07:41 PM |
| Bradway Robert A | Chairman, President and CEO | Mar 15, 2013 | Option Exercise | $92.18 | 18,046 | 1,663,480 | 142,911 | Mar 19, 2013, 07:40 PM |
| Balachandran Madhavan | EVP, Operations | Mar 15, 2013 | Option Exercise | $92.18 | 5,188 | 478,230 | 48,920 | Mar 19, 2013, 07:37 PM |
| HOOPER ANTHONY C | EVP, Global Commercial Ops. | Mar 13, 2013 | Option Exercise | $91.75 | 27,540 | 2,526,795 | 93,060 | Mar 14, 2013, 06:20 PM |
| de Carbonnel Francois | Director | Mar 13, 2013 | Option Exercise | $91.75 | 7,177 | 658,490 | 10,628 | Mar 14, 2013, 06:18 PM |
| de Carbonnel Francois | Director | Mar 13, 2013 | Option Exercise | $54.74 | 10,000 | 547,400 | 17,805 | Mar 14, 2013, 06:18 PM |
| HOOPER ANTHONY C | EVP, Global Commercial Ops. | Mar 02, 2013 | Option Exercise | $92.58 | 6,998 | 647,875 | 71,932 | Mar 04, 2013, 06:28 PM |
| BALTIMORE DAVID | Director | Feb 28, 2013 | Option Exercise | $91.03 | 4,114 | 374,497 | 31,412 | Mar 01, 2013, 05:31 PM |
| BALTIMORE DAVID | Director | Feb 28, 2013 | Option Exercise | $74.89 | 5,000 | 374,450 | 35,526 | Mar 01, 2013, 05:31 PM |
| BALTIMORE DAVID | Director | Feb 28, 2013 | Sale | $92.94 | 886 | 82,345 | 30,526 | Mar 01, 2013, 05:31 PM |
| HERRINGER FRANK C | Director | Feb 26, 2013 | Option Exercise | $89.55 | 4,182 | 374,498 | 17,080 | Feb 26, 2013, 06:20 PM |
| HERRINGER FRANK C | Director | Feb 26, 2013 | Option Exercise | $74.89 | 5,000 | 374,450 | 21,262 | Feb 26, 2013, 06:20 PM |
| PELHAM JUDITH C | Director | Feb 08, 2013 | Option Exercise | $62.55 | 5,000 | 312,750 | 26,304 | Feb 11, 2013, 07:56 PM |
| PELHAM JUDITH C | Director | Feb 08, 2013 | Sale | $86.94 | 5,000 | 434,715 | 21,304 | Feb 11, 2013, 07:56 PM |
| Bradway Robert A | President and CEO | Dec 20, 2012 | Option Exercise | $88.49 | 34,233 | 3,029,278 | 107,478 | Dec 20, 2012, 06:34 PM |
| Bradway Robert A | President and CEO | Dec 20, 2012 | Option Exercise | $64.56 | 40,000 | 2,582,400 | 141,711 | Dec 20, 2012, 06:34 PM |
| BALTIMORE DAVID | Director | Dec 10, 2012 | Option Exercise | $88.32 | 9,200 | 812,544 | 37,326 | Dec 12, 2012, 06:40 PM |
| BALTIMORE DAVID | Director | Dec 10, 2012 | Option Exercise | $50.78 | 16,000 | 812,480 | 46,526 | Dec 12, 2012, 06:40 PM |
| BALTIMORE DAVID | Director | Dec 10, 2012 | Sale | $89.00 | 6,800 | 605,220 | 30,526 | Dec 12, 2012, 06:40 PM |
| SCHAEFFER LEONARD D | Director | Dec 07, 2012 | Option Exercise | $51.71 | 15,000 | 775,600 | 31,329 | Dec 10, 2012, 07:09 PM |
| SCHAEFFER LEONARD D | Director | Dec 07, 2012 | Sale | $87.92 | 15,000 | 1,318,830 | 16,329 | Dec 10, 2012, 07:09 PM |
| BIONDI FRANK | Director | Nov 29, 2012 | Option Exercise | $74.89 | 5,000 | 374,450 | 32,833 | Nov 29, 2012, 06:50 PM |
| BIONDI FRANK | Director | Nov 29, 2012 | Sale | $88.10 | 5,000 | 440,512 | 27,833 | Nov 29, 2012, 06:50 PM |
| OMENN GILBERT S | Director | Nov 26, 2012 | Option Exercise | $57.68 | 26,000 | 1,499,680 | 202,783 | Nov 26, 2012, 08:45 PM |
| OMENN GILBERT S | Director | Nov 26, 2012 | Sale | $87.11 | 26,000 | 2,264,985 | 176,783 | Nov 26, 2012, 08:45 PM |
| Peacock Jonathan M | EVP & CFO | Oct 28, 2012 | Option Exercise | $87.63 | 11,671 | 1,022,730 | 102,438 | Oct 29, 2012, 08:05 PM |
| Patton Cynthia M | SVP & CCO | Oct 28, 2012 | Option Exercise | $87.63 | 367 | 32,160 | 12,607 | Oct 29, 2012, 07:49 PM |
| SHARER KEVIN W | Director | Oct 24, 2012 | Option Exercise | $71.88 | 195,000 | 14,016,599 | 296,018 | Oct 25, 2012, 06:32 PM |
| SHARER KEVIN W | Director | Oct 24, 2012 | Sale | $88.13 | 263,000 | 23,178,598 | 32,999 | Oct 25, 2012, 06:32 PM |
| SHARER KEVIN W | Director | Sep 11, 2012 | Option Exercise | $61.36 | 274,625 | 16,849,739 | 375,643 | Sep 12, 2012, 05:24 PM |
| SHARER KEVIN W | Director | Sep 11, 2012 | Sale | $83.96 | 349,625 | 29,355,365 | 148,494 | Sep 12, 2012, 05:24 PM |
| SCHAEFFER LEONARD D | Director | Aug 30, 2012 | Option Exercise | $74.89 | 5,000 | 374,450 | 21,316 | Aug 31, 2012, 06:00 PM |
| SCHAEFFER LEONARD D | Director | Aug 30, 2012 | Sale | $83.25 | 5,000 | 416,254 | 16,316 | Aug 31, 2012, 06:00 PM |
| PELHAM JUDITH C | Director | Aug 24, 2012 | Option Exercise | $74.89 | 5,000 | 374,450 | 26,304 | Aug 27, 2012, 06:53 PM |
| PELHAM JUDITH C | Director | Aug 24, 2012 | Sale | $84.37 | 5,000 | 421,833 | 21,304 | Aug 27, 2012, 06:53 PM |
| REASON J PAUL | Director | Aug 09, 2012 | Sale | $81.93 | 4,500 | 368,692 | 23,591 | Aug 13, 2012, 06:56 PM |
| REASON J PAUL | Director | Aug 06, 2012 | Option Exercise | $82.21 | 16,317 | 1,341,421 | 40,603 | Aug 08, 2012, 06:14 PM |
| REASON J PAUL | Director | Aug 06, 2012 | Option Exercise | $53.65 | 25,000 | 1,341,200 | 44,408 | Aug 08, 2012, 06:14 PM |
| RICHO ANNA | SVP & CCO | Aug 01, 2012 | Option Exercise | $62.63 | 5,125 | 320,979 | 41,992 | Aug 01, 2012, 07:50 PM |
| RICHO ANNA | SVP & CCO | Aug 01, 2012 | Sale | $83.06 | 5,125 | 425,698 | 10,256 | Aug 01, 2012, 07:50 PM |
| Dittrich Thomas J.W. | VP, Finance & CAO | Jul 31, 2012 | Option Exercise | $65.28 | 32,150 | 2,098,645 | 45,871 | Aug 01, 2012, 07:39 PM |
| Dittrich Thomas J.W. | VP, Finance & CAO | Jul 31, 2012 | Sale | $82.69 | 32,150 | 2,658,387 | 13,721 | Aug 01, 2012, 07:39 PM |
| SCOTT DAVID J | SVP, Gen. Counsel & Secy. | Jul 30, 2012 | Option Exercise | $58.60 | 113,500 | 6,651,180 | 179,058 | Jul 31, 2012, 08:00 PM |
| SCOTT DAVID J | SVP, Gen. Counsel & Secy. | Jul 30, 2012 | Sale | $84.11 | 113,500 | 9,546,578 | 177,667 | Jul 31, 2012, 08:00 PM |
| SCOTT DAVID J | SVP, Gen. Counsel & Secy. | Jul 27, 2012 | Sale | $82.00 | 30,000 | 2,460,000 | 65,558 | Jul 31, 2012, 08:00 PM |
| RICHO ANNA | SVP & CCO | Jul 27, 2012 | Option Exercise | $71.88 | 7,875 | 566,055 | 44,742 | Jul 31, 2012, 07:52 PM |
| RICHO ANNA | SVP & CCO | Jul 27, 2012 | Sale | $81.81 | 7,875 | 644,230 | 10,256 | Jul 31, 2012, 07:52 PM |
| MCNAMEE BRIAN M | SVP, Human Resources | Jul 27, 2012 | Option Exercise | $62.53 | 85,098 | 5,321,035 | 138,387 | Jul 31, 2012, 07:46 PM |
| MCNAMEE BRIAN M | SVP, Human Resources | Jul 27, 2012 | Sale | $82.73 | 85,598 | 7,081,859 | 53,289 | Jul 31, 2012, 07:46 PM |
| Harper Sean E | EVP, Research & Development | Jul 27, 2012 | Option Exercise | $68.43 | 39,900 | 2,730,172 | 84,332 | Jul 31, 2012, 07:35 PM |
| Harper Sean E | EVP, Research & Development | Jul 27, 2012 | Sale | $82.33 | 39,900 | 3,285,087 | 52,432 | Jul 31, 2012, 07:35 PM |
| BONANNI FABRIZIO | EVP, Operations | Jul 27, 2012 | Option Exercise | $54.53 | 303,011 | 16,522,165 | 376,510 | Jul 31, 2012, 07:31 PM |
| BONANNI FABRIZIO | EVP, Operations | Jul 27, 2012 | Sale | $82.14 | 303,011 | 24,888,718 | 60,628 | Jul 31, 2012, 07:31 PM |
| BONANNI FABRIZIO | EVP, Operations | Jul 30, 2012 | Sale | $84.33 | 12,137 | 1,023,562 | 48,491 | Jul 31, 2012, 07:31 PM |
| SHARER KEVIN W | Director | Jul 27, 2012 | Option Exercise | $46.28 | 128,000 | 5,924,480 | 228,979 | Jul 31, 2012, 07:26 PM |
| SHARER KEVIN W | Director | Jul 27, 2012 | Sale | $82.68 | 128,000 | 10,583,346 | 218,748 | Jul 31, 2012, 07:26 PM |
| REASON J PAUL | Director | Jul 30, 2012 | Option Exercise | $83.92 | 8,731 | 732,706 | 23,677 | Jul 31, 2012, 07:21 PM |
| REASON J PAUL | Director | Jul 30, 2012 | Option Exercise | $73.26 | 10,000 | 732,650 | 28,139 | Jul 31, 2012, 07:21 PM |
| BIONDI FRANK | Director | Jul 27, 2012 | Option Exercise | $48.72 | 21,000 | 1,023,130 | 48,785 | Jul 31, 2012, 07:14 PM |
| BIONDI FRANK | Director | Jul 27, 2012 | Sale | $82.30 | 21,000 | 1,728,300 | 27,785 | Jul 31, 2012, 07:14 PM |
| de Carbonnel Francois | Director | May 24, 2012 | Option Exercise | $68.38 | 968 | 66,192 | 8,197 | May 29, 2012, 06:16 PM |
| MCNAMEE BRIAN M | SVP, Human Resources | May 17, 2012 | Sale | $70.79 | 3,334 | 236,026 | 53,266 | May 21, 2012, 06:16 PM |
| PELHAM JUDITH C | Director | May 18, 2012 | Option Exercise | $50.78 | 16,000 | 812,480 | 37,304 | May 21, 2012, 06:10 PM |
| PELHAM JUDITH C | Director | May 18, 2012 | Sale | $69.06 | 16,000 | 1,104,989 | 21,304 | May 21, 2012, 06:10 PM |
| BEIER DAVID W | SVP, Global Govt Affairs | May 03, 2012 | Option Exercise | $55.89 | 55,000 | 3,073,750 | 90,612 | May 07, 2012, 05:37 PM |
| BEIER DAVID W | SVP, Global Govt Affairs | May 03, 2012 | Sale | $70.72 | 55,000 | 3,889,369 | 35,612 | May 07, 2012, 05:37 PM |
| BONANNI FABRIZIO | EVP, Operations | May 03, 2012 | Sale | $70.86 | 6,572 | 465,679 | 65,557 | May 04, 2012, 06:52 PM |
| SHARER KEVIN W | Chairman of the Board and CEO | May 03, 2012 | Sale | $71.09 | 7,000 | 497,626 | 148,494 | May 04, 2012, 06:47 PM |
| Harper Sean E | EVP, Research & Development | May 03, 2012 | Option Exercise | $71.17 | 11,453 | 815,110 | 59,145 | May 03, 2012, 09:13 PM |
| Harper Sean E | EVP, Research & Development | May 03, 2012 | Option Exercise | $46.88 | 14,000 | 656,300 | 63,840 | May 03, 2012, 09:13 PM |
| RICHO ANNA | SVP & CCO | May 01, 2012 | Option Exercise | $71.11 | 2,309 | 164,193 | 37,122 | May 03, 2012, 07:43 PM |
| RICHO ANNA | SVP & CCO | May 01, 2012 | Option Exercise | $52.85 | 22,950 | 1,212,983 | 56,481 | May 03, 2012, 07:43 PM |
| RICHO ANNA | SVP & CCO | May 01, 2012 | Sale | $70.78 | 20,000 | 1,415,571 | 46,481 | May 03, 2012, 07:43 PM |
| SCOTT DAVID J | SVP, Gen. Counsel & Secy. | Apr 29, 2012 | Option Exercise | $71.64 | 1,331 | 95,353 | 95,527 | May 01, 2012, 09:11 PM |
| SCOTT DAVID J | SVP, Gen. Counsel & Secy. | Apr 28, 2012 | Option Exercise | $71.64 | 666 | 47,712 | 96,858 | May 01, 2012, 09:11 PM |
| SHARER KEVIN W | Chairman of the Board and CEO | Apr 29, 2012 | Option Exercise | $71.64 | 4,184 | 299,742 | 105,999 | May 01, 2012, 09:09 PM |
| SHARER KEVIN W | Chairman of the Board and CEO | Apr 28, 2012 | Option Exercise | $71.64 | 4,184 | 299,742 | 115,249 | May 01, 2012, 09:09 PM |
| RICHO ANNA | SVP & CCO | Apr 29, 2012 | Option Exercise | $71.64 | 394 | 28,226 | 36,930 | May 01, 2012, 09:07 PM |
| RICHO ANNA | SVP & CCO | Apr 28, 2012 | Option Exercise | $71.64 | 666 | 47,712 | 38,083 | May 01, 2012, 09:07 PM |
| MCNAMEE BRIAN M | SVP, Human Resources | Apr 28, 2012 | Option Exercise | $71.64 | 645 | 46,208 | 57,890 | May 01, 2012, 09:00 PM |
| MCNAMEE BRIAN M | SVP, Human Resources | Apr 29, 2012 | Option Exercise | $71.64 | 1,290 | 92,416 | 56,600 | May 01, 2012, 09:00 PM |
| Harper Sean E | EVP, Research & Development | Apr 29, 2012 | Option Exercise | $71.64 | 2,545 | 182,324 | 49,840 | May 01, 2012, 08:51 PM |
| Harper Sean E | EVP, Research & Development | Apr 28, 2012 | Option Exercise | $71.64 | 526 | 37,683 | 52,385 | May 01, 2012, 08:51 PM |
| Dittrich Thomas J.W. | VP, Finance & CAO | Apr 29, 2012 | Option Exercise | $71.64 | 233 | 16,692 | 13,714 | May 01, 2012, 08:45 PM |
| Dittrich Thomas J.W. | VP, Finance & CAO | Apr 28, 2012 | Option Exercise | $71.64 | 78 | 5,588 | 13,947 | May 01, 2012, 08:45 PM |
| Bradway Robert A | President and COO | Apr 28, 2012 | Option Exercise | $71.64 | 1,401 | 100,368 | 102,827 | May 01, 2012, 08:42 PM |
| Bradway Robert A | President and COO | Apr 29, 2012 | Option Exercise | $71.64 | 1,401 | 100,368 | 101,426 | May 01, 2012, 08:42 PM |
| BONANNI FABRIZIO | EVP, Operations | Apr 29, 2012 | Option Exercise | $71.64 | 1,357 | 97,215 | 75,097 | May 01, 2012, 08:40 PM |
| BONANNI FABRIZIO | EVP, Operations | Apr 28, 2012 | Option Exercise | $71.64 | 1,357 | 97,215 | 78,097 | May 01, 2012, 08:40 PM |
| BEIER DAVID W | SVP, Global Govt Affairs | Apr 29, 2012 | Option Exercise | $71.64 | 1,267 | 90,768 | 35,612 | May 01, 2012, 08:37 PM |
| BEIER DAVID W | SVP, Global Govt Affairs | Apr 28, 2012 | Option Exercise | $71.64 | 634 | 45,420 | 36,879 | May 01, 2012, 08:37 PM |
| Dittrich Thomas J.W. | VP, Finance & CAO | Apr 26, 2012 | Option Exercise | $70.19 | 84 | 5,896 | 12,625 | Apr 30, 2012, 06:03 PM |
| SHARER KEVIN W | Chairman of the Board and CEO | Apr 26, 2012 | Option Exercise | $70.19 | 5,145 | 361,128 | 196,355 | Apr 30, 2012, 05:21 PM |
| SHARER KEVIN W | Chairman of the Board and CEO | Apr 26, 2012 | Option Exercise | $58.43 | 79,625 | 4,652,489 | 201,500 | Apr 30, 2012, 05:21 PM |
| SHARER KEVIN W | Chairman of the Board and CEO | Apr 26, 2012 | Sale | $70.86 | 130,425 | 9,242,181 | 196,162 | Apr 30, 2012, 05:21 PM |
| SCOTT DAVID J | SVP, Gen. Counsel & Secy. | Apr 26, 2012 | Option Exercise | $70.19 | 677 | 47,519 | 91,383 | Apr 30, 2012, 05:18 PM |
| RICHO ANNA | SVP & CCO | Apr 26, 2012 | Option Exercise | $70.19 | 677 | 47,519 | 36,172 | Apr 30, 2012, 05:16 PM |
| MCNAMEE BRIAN M | SVP, Human Resources | Apr 26, 2012 | Option Exercise | $70.19 | 656 | 46,045 | 54,069 | Apr 30, 2012, 05:14 PM |
| MCNAMEE BRIAN M | SVP, Human Resources | Apr 26, 2012 | Sale | $70.85 | 2,500 | 177,125 | 54,725 | Apr 30, 2012, 05:14 PM |
| Harper Sean E | EVP, Research & Development | Apr 26, 2012 | Option Exercise | $70.19 | 514 | 36,078 | 44,257 | Apr 30, 2012, 05:12 PM |
| Bradway Robert A | President and COO | Apr 26, 2012 | Option Exercise | $70.19 | 2,102 | 147,539 | 83,290 | Apr 30, 2012, 05:09 PM |
| BONANNI FABRIZIO | EVP, Operations | Apr 26, 2012 | Option Exercise | $70.19 | 1,357 | 95,248 | 72,443 | Apr 30, 2012, 05:06 PM |
| BEIER DAVID W | SVP, Global Govt Affairs | Apr 26, 2012 | Option Exercise | $70.19 | 645 | 45,273 | 34,163 | Apr 30, 2012, 05:02 PM |
| SHARER KEVIN W | Chairman of the Board and CEO | Mar 16, 2012 | Option Exercise | $68.26 | 15,505 | 1,058,371 | 139,585 | Mar 20, 2012, 06:02 PM |
| SCOTT DAVID J | SVP, Gen. Counsel & Secy. | Mar 16, 2012 | Option Exercise | $68.26 | 2,443 | 166,759 | 92,060 | Mar 20, 2012, 06:00 PM |
| RICHO ANNA | SVP & CCO | Mar 16, 2012 | Option Exercise | $68.26 | 2,341 | 159,797 | 39,740 | Mar 20, 2012, 05:58 PM |
| MCNAMEE BRIAN M | SVP, Human Resources | Mar 16, 2012 | Option Exercise | $68.26 | 2,443 | 166,759 | 58,725 | Mar 20, 2012, 05:56 PM |
| Harper Sean E | EVP, Research & Development | Mar 16, 2012 | Option Exercise | $68.26 | 1,519 | 103,687 | 44,771 | Mar 20, 2012, 05:50 PM |
| Dittrich Thomas J.W. | VP, Finance & CAO | Mar 16, 2012 | Option Exercise | $68.26 | 283 | 19,318 | 12,709 | Mar 20, 2012, 05:48 PM |
| Bradway Robert A | President and COO | Mar 16, 2012 | Option Exercise | $68.26 | 5,017 | 342,460 | 85,392 | Mar 20, 2012, 05:44 PM |
| BEIER DAVID W | SVP, Global Govt Affairs | Mar 16, 2012 | Option Exercise | $68.26 | 2,326 | 158,773 | 34,808 | Mar 20, 2012, 05:42 PM |
| BONANNI FABRIZIO | EVP, Operations | Mar 16, 2012 | Option Exercise | $68.26 | 5,098 | 347,989 | 79,622 | Mar 20, 2012, 05:39 PM |
| BALTIMORE DAVID | Director | Mar 08, 2012 | Option Exercise | $66.95 | 4,378 | 293,107 | 29,131 | Mar 12, 2012, 07:50 PM |
| BALTIMORE DAVID | Director | Mar 08, 2012 | Option Exercise | $58.61 | 5,000 | 293,050 | 33,509 | Mar 12, 2012, 07:50 PM |
| HOOPER ANTHONY C | EVP, Global Commercial Ops. | Mar 02, 2012 | Option Exercise | $67.59 | 13,162 | 889,620 | 62,655 | Mar 05, 2012, 05:25 PM |
| BIONDI FRANK | Director | Mar 01, 2012 | Option Exercise | $58.61 | 5,000 | 293,050 | 31,188 | Mar 01, 2012, 06:35 PM |
| BIONDI FRANK | Director | Mar 01, 2012 | Sale | $67.57 | 5,000 | 337,826 | 26,188 | Mar 01, 2012, 06:35 PM |
| OMENN GILBERT S | Director | Feb 29, 2012 | Option Exercise | $68.15 | 4,301 | 293,113 | 183,852 | Feb 29, 2012, 06:28 PM |
| OMENN GILBERT S | Director | Feb 29, 2012 | Option Exercise | $58.61 | 5,000 | 293,050 | 188,153 | Feb 29, 2012, 06:28 PM |
| HERRINGER FRANK C | Director | Feb 17, 2012 | Option Exercise | $68.89 | 4,254 | 293,058 | 15,279 | Feb 21, 2012, 07:57 PM |
| HERRINGER FRANK C | Director | Feb 17, 2012 | Option Exercise | $58.61 | 5,000 | 293,050 | 19,533 | Feb 21, 2012, 07:57 PM |
| SCHAEFFER LEONARD D | Director | Feb 16, 2012 | Option Exercise | $67.90 | 4,316 | 293,056 | 14,860 | Feb 16, 2012, 07:20 PM |
| SCHAEFFER LEONARD D | Director | Feb 16, 2012 | Option Exercise | $58.61 | 5,000 | 293,050 | 19,176 | Feb 16, 2012, 07:20 PM |
| PELHAM JUDITH C | Director | Feb 13, 2012 | Option Exercise | $58.61 | 5,000 | 293,050 | 24,909 | Feb 14, 2012, 08:29 PM |
| PELHAM JUDITH C | Director | Feb 13, 2012 | Sale | $68.30 | 5,000 | 341,500 | 19,909 | Feb 14, 2012, 08:29 PM |
| BEIER DAVID W | SVP, Global Govt Affairs | Feb 07, 2012 | Option Exercise | $54.43 | 20,000 | 1,088,700 | 51,902 | Feb 07, 2012, 08:32 PM |
| BEIER DAVID W | SVP, Global Govt Affairs | Feb 07, 2012 | Sale | $68.88 | 20,000 | 1,377,678 | 31,902 | Feb 07, 2012, 08:32 PM |
| PERLMUTTER ROGER M | EVP, Research & Development | Feb 02, 2012 | Option Exercise | $58.61 | 75,000 | 4,395,750 | 261,031 | Feb 06, 2012, 05:35 PM |
| PERLMUTTER ROGER M | EVP, Research & Development | Feb 02, 2012 | Sale | $69.83 | 75,000 | 5,237,325 | 186,031 | Feb 06, 2012, 05:35 PM |
| BONANNI FABRIZIO | EVP, Operations | Feb 01, 2012 | Sale | $69.63 | 7,745 | 539,321 | 56,449 | Feb 02, 2012, 08:04 PM |
| Dittrich Thomas J.W. | VP, Finance & CAO | Jan 30, 2012 | Option Exercise | $53.33 | 26,150 | 1,394,604 | 38,102 | Feb 01, 2012, 06:41 PM |
| Dittrich Thomas J.W. | VP, Finance & CAO | Jan 30, 2012 | Sale | $68.26 | 26,150 | 1,784,931 | 11,952 | Feb 01, 2012, 06:41 PM |
| SCOTT DAVID J | SVP, Gen. Counsel & Secy. | Jan 27, 2012 | Option Exercise | $57.22 | 113,500 | 6,494,025 | 200,690 | Jan 31, 2012, 09:08 PM |
| SCOTT DAVID J | SVP, Gen. Counsel & Secy. | Jan 27, 2012 | Sale | $68.62 | 133,500 | 9,161,019 | 150,690 | Jan 31, 2012, 09:08 PM |
| SHARER KEVIN W | Chairman of the Board and CEO | Jan 27, 2012 | Option Exercise | $50.89 | 545,000 | 27,732,530 | 666,875 | Jan 31, 2012, 09:04 PM |
| SHARER KEVIN W | Chairman of the Board and CEO | Jan 27, 2012 | Sale | $68.58 | 545,000 | 37,377,259 | 176,414 | Jan 31, 2012, 09:04 PM |
| RICHO ANNA | SVP & CCO | Jan 27, 2012 | Option Exercise | $60.96 | 46,446 | 2,831,458 | 83,295 | Jan 31, 2012, 08:52 PM |
| RICHO ANNA | SVP & CCO | Jan 27, 2012 | Sale | $68.47 | 45,446 | 3,111,592 | 4,743 | Jan 31, 2012, 08:52 PM |
| MCNAMEE BRIAN M | SVP, Human Resources | Jan 27, 2012 | Option Exercise | $56.12 | 131,902 | 7,402,870 | 172,757 | Jan 31, 2012, 08:47 PM |
| MCNAMEE BRIAN M | SVP, Human Resources | Jan 27, 2012 | Sale | $68.68 | 138,902 | 9,540,081 | 40,855 | Jan 31, 2012, 08:47 PM |
| BONANNI FABRIZIO | EVP, Operations | Jan 27, 2012 | Option Exercise | $58.61 | 50,000 | 2,930,500 | 123,800 | Jan 31, 2012, 08:44 PM |
| BONANNI FABRIZIO | EVP, Operations | Jan 27, 2012 | Sale | $68.44 | 50,000 | 3,421,920 | 64,194 | Jan 31, 2012, 08:44 PM |
| BEIER DAVID W | SVP, Global Govt Affairs | Jan 27, 2012 | Option Exercise | $48.59 | 57,500 | 2,793,975 | 89,402 | Jan 31, 2012, 08:41 PM |
| BEIER DAVID W | SVP, Global Govt Affairs | Jan 27, 2012 | Sale | $68.47 | 57,500 | 3,936,904 | 31,902 | Jan 31, 2012, 08:41 PM |
| REASON J PAUL | Director | Jan 13, 2012 | Option Exercise | $67.54 | 4,339 | 293,056 | 16,620 | Jan 13, 2012, 04:12 PM |
| REASON J PAUL | Director | Jan 13, 2012 | Option Exercise | $58.61 | 5,000 | 293,050 | 20,959 | Jan 13, 2012, 04:12 PM |
| BIONDI FRANK | Director | Jan 12, 2012 | Option Exercise | $66.40 | 13,567 | 900,849 | 26,188 | Jan 12, 2012, 04:36 PM |
| BIONDI FRANK | Director | Jan 12, 2012 | Option Exercise | $56.30 | 16,000 | 900,800 | 39,755 | Jan 12, 2012, 04:36 PM |
| REASON J PAUL | Director | Dec 22, 2011 | Option Exercise | $63.14 | 14,267 | 900,818 | 15,959 | Dec 22, 2011, 04:47 PM |
| REASON J PAUL | Director | Dec 22, 2011 | Option Exercise | $56.30 | 16,000 | 900,800 | 30,226 | Dec 22, 2011, 04:47 PM |
| PELHAM JUDITH C | Director | Dec 22, 2011 | Option Exercise | $63.14 | 14,267 | 900,818 | 19,909 | Dec 22, 2011, 04:45 PM |
| PELHAM JUDITH C | Director | Dec 22, 2011 | Option Exercise | $56.30 | 16,000 | 900,800 | 34,176 | Dec 22, 2011, 04:45 PM |
| OMENN GILBERT S | Director | Dec 22, 2011 | Option Exercise | $63.14 | 14,267 | 900,818 | 183,153 | Dec 22, 2011, 04:43 PM |
| OMENN GILBERT S | Director | Dec 22, 2011 | Option Exercise | $56.30 | 16,000 | 900,800 | 197,420 | Dec 22, 2011, 04:43 PM |
| BIONDI FRANK | Director | Dec 22, 2011 | Option Exercise | $63.14 | 52,921 | 3,341,432 | 23,755 | Dec 22, 2011, 04:39 PM |
| BIONDI FRANK | Director | Dec 22, 2011 | Option Exercise | $55.69 | 60,000 | 3,341,400 | 76,676 | Dec 22, 2011, 04:39 PM |
| BALTIMORE DAVID | Director | Dec 22, 2011 | Option Exercise | $63.14 | 14,267 | 900,818 | 28,509 | Dec 22, 2011, 04:36 PM |
| BALTIMORE DAVID | Director | Dec 22, 2011 | Option Exercise | $56.30 | 16,000 | 900,800 | 42,776 | Dec 22, 2011, 04:36 PM |
| RICHO ANNA | SVP & CCO | Nov 08, 2011 | Sale | $58.07 | 1,500 | 87,105 | 3,743 | Nov 09, 2011, 09:04 PM |
| SHARER KEVIN W | Chairman of the Board and CEO | Nov 08, 2011 | Sale | $58.22 | 52,500 | 3,056,608 | 172,222 | Nov 09, 2011, 09:01 PM |
| BONANNI FABRIZIO | EVP, Operations | Nov 08, 2011 | Sale | $58.12 | 10,000 | 581,233 | 64,194 | Nov 09, 2011, 08:57 PM |
| Peacock Jonathan M | EVP & CFO | Oct 28, 2011 | Option Exercise | $58.06 | 10,427 | 605,392 | 105,373 | Oct 31, 2011, 07:59 PM |
| MCNAMEE BRIAN M | SVP, Human Resources | Sep 07, 2011 | Sale | $54.73 | 1,000 | 54,730 | 42,847 | Sep 08, 2011, 01:37 PM |
| SCOTT DAVID J | SVP, Gen. Counsel & Secy. | Aug 31, 2011 | Sale | $55.44 | 20,000 | 1,108,828 | 87,190 | Sep 01, 2011, 02:52 PM |
| BEIER DAVID W | SVP Global Govt & Corp Affairs | Aug 15, 2011 | Sale | $51.56 | 15,000 | 773,471 | 31,902 | Aug 15, 2011, 06:50 PM |
| de Carbonnel Francois | Director | Aug 04, 2011 | Buy | $53.02 | 1,000 | 53,020 | 7,321 | Aug 08, 2011, 05:21 PM |
| Dittrich Thomas J.W. | VP, Finance & CAO | Jul 31, 2011 | Option Exercise | $54.70 | 679 | 37,141 | 11,952 | Aug 02, 2011, 08:59 PM |
| RICHO ANNA | SVP & CCO | Jul 31, 2011 | Option Exercise | $54.70 | 918 | 50,215 | 37,125 | Aug 02, 2011, 07:08 PM |
| RICHO ANNA | SVP & CCO | Aug 01, 2011 | Option Exercise | $49.37 | 22,950 | 1,133,083 | 58,493 | Aug 02, 2011, 07:08 PM |
| RICHO ANNA | SVP & CCO | Aug 01, 2011 | Sale | $55.01 | 2,000 | 110,024 | 5,243 | Aug 02, 2011, 07:08 PM |
| RICHO ANNA | SVP & CCO | Aug 01, 2011 | Sale | $55.02 | 22,950 | 1,262,597 | 55,543 | Aug 02, 2011, 07:08 PM |
| Dittrich Thomas J.W. | VP, Finance & CAO | Apr 29, 2011 | Option Exercise | $57.14 | 233 | 13,314 | 11,774 | May 02, 2011, 07:45 PM |
| Dittrich Thomas J.W. | VP, Finance & CAO | Apr 28, 2011 | Option Exercise | $56.82 | 78 | 4,432 | 12,007 | May 02, 2011, 07:45 PM |
| SHARER KEVIN W | Chairman of the Board and CEO | Apr 29, 2011 | Option Exercise | $57.14 | 4,184 | 239,074 | 126,941 | May 02, 2011, 07:26 PM |
| SHARER KEVIN W | Chairman of the Board and CEO | Apr 28, 2011 | Option Exercise | $56.82 | 4,184 | 237,735 | 136,191 | May 02, 2011, 07:26 PM |
| SCOTT DAVID J | SVP, Gen. Counsel & Secy. | Apr 29, 2011 | Option Exercise | $57.14 | 1,331 | 76,053 | 107,190 | May 02, 2011, 07:23 PM |
| SCOTT DAVID J | SVP, Gen. Counsel & Secy. | Apr 28, 2011 | Option Exercise | $56.82 | 666 | 37,842 | 108,521 | May 02, 2011, 07:23 PM |
| RICHO ANNA | SVP & CCO | Apr 29, 2011 | Option Exercise | $57.14 | 310 | 17,713 | 38,576 | May 02, 2011, 07:20 PM |
| RICHO ANNA | SVP & CCO | Apr 28, 2011 | Option Exercise | $56.82 | 523 | 29,717 | 39,788 | May 02, 2011, 07:20 PM |
| PERLMUTTER ROGER M | EVP, Research & Development | Apr 29, 2011 | Option Exercise | $57.14 | 1,357 | 77,539 | 186,031 | May 02, 2011, 07:18 PM |
| PERLMUTTER ROGER M | EVP, Research & Development | Apr 28, 2011 | Option Exercise | $56.82 | 1,357 | 77,105 | 187,388 | May 02, 2011, 07:18 PM |
| MCNAMEE BRIAN M | SVP, Human Resources | Apr 29, 2011 | Option Exercise | $57.14 | 1,331 | 76,053 | 43,847 | May 02, 2011, 07:15 PM |
| MCNAMEE BRIAN M | SVP, Human Resources | Apr 28, 2011 | Option Exercise | $56.82 | 664 | 37,728 | 45,178 | May 02, 2011, 07:15 PM |
| Bradway Robert A | President and COO | Apr 29, 2011 | Option Exercise | $57.14 | 1,401 | 80,053 | 79,489 | May 02, 2011, 07:12 PM |
| Bradway Robert A | President and COO | Apr 28, 2011 | Option Exercise | $56.82 | 1,401 | 79,605 | 80,890 | May 02, 2011, 07:12 PM |
| BONANNI FABRIZIO | EVP, Operations | Apr 29, 2011 | Option Exercise | $57.14 | 1,357 | 77,539 | 75,443 | May 02, 2011, 07:09 PM |
| BONANNI FABRIZIO | EVP, Operations | Apr 28, 2011 | Option Exercise | $56.82 | 1,357 | 77,105 | 78,443 | May 02, 2011, 07:09 PM |
| BEIER DAVID W | SVP Global Govt & Corp Affairs | Apr 28, 2011 | Option Exercise | $56.82 | 561 | 31,876 | 48,150 | May 02, 2011, 07:06 PM |
| BEIER DAVID W | SVP Global Govt & Corp Affairs | Apr 29, 2011 | Option Exercise | $57.14 | 1,248 | 71,311 | 46,902 | May 02, 2011, 07:06 PM |
| SCOTT DAVID J | SVP, Gen. Counsel & Secy. | Apr 26, 2011 | Option Exercise | $54.69 | 677 | 37,025 | 109,187 | Apr 27, 2011, 09:23 PM |
| RICHO ANNA | SVP & CCO | Apr 26, 2011 | Option Exercise | $54.69 | 532 | 29,095 | 41,229 | Apr 27, 2011, 09:20 PM |
| PERLMUTTER ROGER M | EVP, Research & Development | Apr 26, 2011 | Option Exercise | $54.69 | 1,357 | 74,214 | 188,745 | Apr 27, 2011, 09:18 PM |
| MCNAMEE BRIAN M | SVP, Human Resources | Apr 26, 2011 | Option Exercise | $54.69 | 532 | 29,095 | 45,842 | Apr 27, 2011, 09:13 PM |
| Dittrich Thomas J.W. | VP, Finance & CAO | Apr 26, 2011 | Option Exercise | $54.69 | 84 | 4,594 | 12,085 | Apr 27, 2011, 09:10 PM |
| Bradway Robert A | President and COO | Apr 26, 2011 | Option Exercise | $54.69 | 2,102 | 114,958 | 82,992 | Apr 27, 2011, 09:08 PM |
| BONANNI FABRIZIO | EVP, Operations | Apr 26, 2011 | Option Exercise | $54.69 | 1,357 | 74,214 | 81,443 | Apr 27, 2011, 09:05 PM |
| BEIER DAVID W | SVP Global Govt & Corp Affairs | Apr 26, 2011 | Option Exercise | $54.69 | 490 | 26,798 | 48,711 | Apr 27, 2011, 09:03 PM |
| SHARER KEVIN W | Chairman of the Board and CEO | Apr 26, 2011 | Option Exercise | $54.69 | 5,145 | 281,380 | 146,605 | Apr 27, 2011, 08:59 PM |
| RICHO ANNA | SVP & CCO | Mar 11, 2011 | Option Exercise | $51.84 | 903 | 46,812 | 35,818 | Mar 15, 2011, 06:43 PM |
| Bradway Robert A | President and COO | Mar 11, 2011 | Option Exercise | $51.84 | 8,179 | 423,999 | 63,393 | Mar 15, 2011, 06:40 PM |
| PERLMUTTER ROGER M | EVP, Research & Development | Mar 11, 2011 | Option Exercise | $51.84 | 8,179 | 423,999 | 174,302 | Mar 15, 2011, 06:38 PM |
| BEIER DAVID W | SVP Global Govt & Corp Affairs | Mar 11, 2011 | Option Exercise | $51.84 | 2,835 | 146,966 | 41,701 | Mar 15, 2011, 06:36 PM |
| Dittrich Thomas J.W. | VP, Finance & CAO | Mar 11, 2011 | Option Exercise | $51.84 | 672 | 34,836 | 10,455 | Mar 15, 2011, 06:33 PM |
| SHARER KEVIN W | Chairman of the Board and CEO | Mar 11, 2011 | Option Exercise | $51.84 | 24,876 | 1,289,572 | 120,164 | Mar 15, 2011, 06:30 PM |
| SCOTT DAVID J | SVP, Gen. Counsel & Secy. | Mar 11, 2011 | Option Exercise | $51.84 | 3,483 | 180,559 | 98,664 | Mar 15, 2011, 06:24 PM |
| BONANNI FABRIZIO | EVP, Operations | Mar 11, 2011 | Option Exercise | $51.84 | 8,034 | 416,483 | 76,486 | Mar 15, 2011, 06:21 PM |
| MCNAMEE BRIAN M | SVP, Human Resources | Mar 11, 2011 | Option Exercise | $51.84 | 3,080 | 159,667 | 38,874 | Mar 15, 2011, 06:17 PM |
| MCNAMEE BRIAN M | Sr. V.P. Human Resources | Feb 01, 2011 | Sale | $55.80 | 5,000 | 279,000 | 33,559 | Feb 02, 2011, 05:01 PM |
| Flanagan Thomas James | Sr VP & CIO | Dec 08, 2010 | Sale | $53.37 | 750 | 40,029 | 41,826 | Dec 09, 2010, 06:39 PM |
| Dittrich Thomas J.W. | VP, Finance & CAO | Dec 02, 2010 | Sale | $53.60 | 3,500 | 187,600 | 8,624 | Dec 06, 2010, 08:19 PM |
| RICHO ANNA | SVP & CCO | Oct 26, 2010 | Option Exercise | $42.13 | 5,900 | 248,567 | 20,161 | Oct 27, 2010, 07:35 PM |
| RICHO ANNA | SVP & CCO | Oct 26, 2010 | Sale | $56.94 | 5,900 | 335,954 | 14,261 | Oct 27, 2010, 07:35 PM |
| GLUCK FREDERICK W | Director | Sep 08, 2010 | Sale | $52.36 | 800 | 41,888 | 15,748 | Sep 10, 2010, 04:23 PM |
| RICHO ANNA | SVP & CCO | Aug 30, 2010 | Sale | $52.34 | 3,000 | 157,020 | 2,607 | Aug 31, 2010, 07:40 PM |
| GLUCK FREDERICK W | Director | Aug 26, 2010 | Sale | $51.76 | 800 | 41,404 | 16,548 | Aug 27, 2010, 12:25 PM |
| BEIER DAVID W | SVP Global Govt & Corp Affairs | Aug 13, 2010 | Option Exercise | $54.94 | 13,000 | 714,220 | 36,141 | Aug 16, 2010, 05:53 PM |
| MCNAMEE BRIAN M | Sr. V.P. Human Resources | Aug 13, 2010 | Option Exercise | $54.99 | 4,000 | 219,960 | 38,559 | Aug 16, 2010, 05:46 PM |
| SHARER KEVIN W | Chairman of the Board and CEO | Aug 13, 2010 | Option Exercise | $54.95 | 29,845 | 1,639,983 | 201,284 | Aug 13, 2010, 05:50 PM |
| Flanagan Thomas James | Sr VP & CIO | Jul 31, 2010 | Option Exercise | $54.53 | 11,671 | 636,420 | 42,576 | Aug 03, 2010, 06:34 PM |
| RICHO ANNA | SVP & CCO | Jul 31, 2010 | Option Exercise | $54.53 | 917 | 50,004 | 15,844 | Aug 03, 2010, 06:32 PM |
| Dittrich Thomas J.W. | VP, Finance & CAO | Jul 31, 2010 | Option Exercise | $54.53 | 677 | 36,917 | 12,124 | Aug 03, 2010, 06:29 PM |
| BEIER DAVID W | SVP Global Govt & Corp Affairs | Jul 31, 2010 | Option Exercise | $54.53 | 11,081 | 604,247 | 49,141 | Aug 03, 2010, 06:27 PM |
| Michael A Kelly | Acting CFO | Jul 31, 2010 | Option Exercise | $54.53 | 917 | 50,004 | 38,814 | Aug 03, 2010, 06:25 PM |
Load More Insider Transactions
Buy
Sale
Option Exercise
| Owner | Relationship | Date | Value($) |
| Grygiel Nancy A. | SVP & CCO | 12/04/2023 | 572,276 |
| Graham Jonathan P | EVP, Gen. Counsel & Secy. | 11/08/2023 | 2,728,136 |
| Miller Derek | SVP, Human Resources | 11/05/2023 | 17,811 |
| Khosla Rachna | SVP, Business Development | 11/05/2023 | 85,546 |
| Grygiel Nancy A. | SVP & CCO | 11/05/2023 | 67,195 |
| Busch Matthew C. | VP, Finance & CAO | 11/05/2023 | 67,195 |
| Griffith Peter H. | EVP & CFO | 11/01/2023 | 895,461 |
| Graham Jonathan P | EVP, Gen. Counsel & Secy. | 11/01/2023 | 447,731 |
| Gordon Murdo | EVP, Global Commercial Ops | 08/10/2023 | 2,508,306 |
| Grygiel Nancy A. | SVP & CCO | 07/31/2023 | 266,862 |
| Santos Esteban | EVP, Operations | 05/05/2023 | 134,264 |
| REESE DAVID M | EVP, Research and Development | 05/05/2023 | 137,743 |
| Miller Derek | SVP, Human Resources | 05/05/2023 | 11,826 |
| Louie Linda H. | VP, Finance & CAO | 05/05/2023 | 3,710 |
| Khosla Rachna | SVP, Business Development | 05/05/2023 | 9,044 |
| Grygiel Nancy A. | SVP & CCO | 05/05/2023 | 12,522 |
| Griffith Peter H. | EVP & CFO | 05/05/2023 | 140,989 |
| Graham Jonathan P | EVP, Gen. Counsel & Secy. | 05/05/2023 | 137,279 |
| Gordon Murdo | EVP, Global Commercial Ops | 05/05/2023 | 144,467 |
| Bradway Robert A | Chairman, CEO and President | 05/05/2023 | 483,027 |
| Grygiel Nancy A. | SVP & CCO | 05/03/2023 | 14,630 |
| Santos Esteban | EVP, Operations | 05/03/2023 | 168,955 |
| REESE DAVID M | EVP, Research and Development | 05/03/2023 | 193,259 |
| Miller Derek | SVP, Human Resources | 05/03/2023 | 13,450 |
| Louie Linda H. | VP, Finance & CAO | 05/02/2023 | 4,719 |
| Khosla Rachna | SVP, Business Development | 05/03/2023 | 13,450 |
| Gordon Murdo | EVP, Global Commercial Ops | 05/03/2023 | 202,698 |
| Graham Jonathan P | EVP, Gen. Counsel & Secy. | 05/03/2023 | 142,054 |
| Bradway Robert A | Chairman, CEO and President | 05/03/2023 | 675,582 |
| Santos Esteban | EVP, Operations | 04/30/2023 | 158,228 |
| REESE DAVID M | EVP, Research and Development | 04/30/2023 | 159,667 |
| Miller Derek | SVP, Human Resources | 04/30/2023 | 11,987 |
| Louie Linda H. | VP, Finance & CAO | 04/30/2023 | 6,473 |
| Khosla Rachna | SVP, Business Development | 04/30/2023 | 11,268 |
| Grygiel Nancy A. | SVP & CCO | 04/30/2023 | 17,501 |
| Griffith Peter H. | EVP & CFO | 04/30/2023 | 139,768 |
| Graham Jonathan P | EVP, Gen. Counsel & Secy. | 04/30/2023 | 159,187 |
| Gordon Murdo | EVP, Global Commercial Ops | 04/30/2023 | 174,531 |
| Bradway Robert A | Chairman, CEO and President | 04/30/2023 | 529,346 |
| Santos Esteban | EVP, Operations | 03/17/2023 | 910,366 |
| REESE DAVID M | EVP, Research and Development | 03/17/2023 | 933,119 |
| Miller Derek | SVP, Human Resources | 03/17/2023 | 75,532 |
| Louie Linda H. | VP, Finance & CAO | 03/17/2023 | 22,519 |
| Khosla Rachna | SVP, Business Development | 03/17/2023 | 56,531 |
| Grygiel Nancy A. | SVP & CCO | 03/17/2023 | 79,519 |
| Griffith Peter H. | EVP & CFO | 03/17/2023 | 798,242 |
| Graham Jonathan P | EVP, Gen. Counsel & Secy. | 03/17/2023 | 887,847 |
| Gordon Murdo | EVP, Global Commercial Ops | 03/17/2023 | 933,119 |
| Bradway Robert A | Chairman, CEO and President | 03/17/2023 | 3,277,178 |
| Khosla Rachna | SVP, Business Development | 11/09/2022 | 113,352 |
| Miller Derek | SVP, Human Resources | 11/05/2022 | 16,950 |
| Louie Linda H. | VP, Finance & CAO | 11/05/2022 | 12,107 |
| Khosla Rachna | SVP, Business Development | 11/05/2022 | 45,199 |
| Grygiel Nancy A. | SVP & CCO | 11/05/2022 | 64,570 |
| Grygiel Nancy A. | SVP & CCO | 11/08/2022 | 159,977 |
| REESE DAVID M | EVP, Research and Development | 11/02/2022 | 663,826 |
| Louie Linda H. | VP, Finance & CAO | 11/02/2022 | 34,007 |
| Griffith Peter H. | EVP & CFO | 11/01/2022 | 819,161 |
| Graham Jonathan P | EVP, Gen. Counsel & Secy. | 11/01/2022 | 444,455 |
| Williams R Sanders | Director | 08/22/2022 | 49,992 |
| ECKERT ROBERT | Director | 08/18/2022 | 1,643,380 |
| ECKERT ROBERT | Director | 08/10/2022 | 1,711,943 |
| ECKERT ROBERT | Director | 08/10/2022 | 1,711,800 |
| Khosla Rachna | SVP, Business Development | 07/31/2022 | 53,701 |
| Grygiel Nancy A. | SVP & CCO | 07/31/2022 | 304,141 |
| Williams R Sanders | Director | 05/23/2022 | 150,000 |
| Graham Jonathan P | EVP, Gen. Counsel & Secy. | 05/10/2022 | 3,264,449 |
| Santos Esteban | EVP, Operations | 05/05/2022 | 139,063 |
| REESE DAVID M | EVP, Research and Development | 05/05/2022 | 135,758 |
| Miller Derek | SVP, Human Resources | 05/05/2022 | 11,569 |
| Louie Linda H. | VP, Finance & CAO | 05/05/2022 | 3,542 |
| Khosla Rachna | SVP, Business Development | 05/05/2022 | 8,736 |
| Grygiel Nancy A. | SVP & CCO | 05/05/2022 | 12,277 |
| Griffith Peter H. | EVP & CFO | 05/05/2022 | 139,063 |
| Graham Jonathan P | EVP, Gen. Counsel & Secy. | 05/05/2022 | 135,521 |
| Gordon Murdo | EVP Global Commercial Ops | 05/05/2022 | 142,368 |
| Bradway Robert A | Chairman, CEO and President | 05/05/2022 | 476,214 |
| Santos Esteban | EVP, Operations | 05/03/2022 | 163,491 |
| REESE DAVID M | EVP, Research and Development | 05/03/2022 | 177,808 |
| Miller Derek | SVP, Human Resources | 05/03/2022 | 12,470 |
| Louie Linda H. | VP, Finance & CAO | 05/03/2022 | 4,157 |
| Khosla Rachna | SVP, Business Development | 05/03/2022 | 12,239 |
| Grygiel Nancy A. | SVP & CCO | 05/02/2022 | 13,162 |
| Graham Jonathan P | EVP, Gen. Counsel & Secy. | 05/03/2022 | 130,701 |
| Gordon Murdo | EVP Global Commercial Ops | 05/03/2022 | 186,583 |
| Bradway Robert A | Chairman, CEO and President | 05/03/2022 | 621,637 |
| Santos Esteban | EVP, Operations | 04/27/2022 | 149,672 |
| REESE DAVID M | EVP, Research and Development | 04/27/2022 | 45,976 |
| Miller Derek | SVP, Human Resources | 04/27/2022 | 68,215 |
| Louie Linda H. | VP, Finance & CAO | 04/27/2022 | 4,248 |
| Khosla Rachna | SVP, Business Development | 04/27/2022 | 6,996 |
| Grygiel Nancy A. | SVP & CCO | 04/27/2022 | 14,992 |
| Graham Jonathan P | EVP, Gen. Counsel & Secy. | 04/27/2022 | 149,672 |
| Bradway Robert A | Chairman, CEO and President | 04/27/2022 | 636,419 |
| Santos Esteban | EVP, Operations | 03/18/2022 | 1,030,708 |
| REESE DAVID M | EVP, Research and Development | 03/18/2022 | 1,178,121 |
| Miller Derek | SVP, Human Resources | 03/18/2022 | 77,126 |
| Louie Linda H. | VP, Finance & CAO | 03/18/2022 | 25,473 |
| Khosla Rachna | SVP, Business Development | 03/18/2022 | 75,947 |
| Grygiel Nancy A. | SVP & CCO | 03/18/2022 | 82,551 |
| Graham Jonathan P | EVP, Gen. Counsel & Secy. | 03/18/2022 | 824,567 |
| Gordon Murdo | EVP Global Commercial Ops | 03/18/2022 | 1,178,121 |
| Bradway Robert A | Chairman, CEO and President | 03/18/2022 | 4,123,069 |
| REESE DAVID M | EVP, Research and Development | 11/02/2021 | 459,750 |
| Gordon Murdo | EVP Global Commercial Ops | 11/02/2021 | 1,171,677 |
| Johnston Lori A | EVP, HR | 11/01/2021 | 279,823 |
| Griffith Peter H. | EVP & CFO | 11/01/2021 | 550,747 |
| Graham Jonathan P | EVP, Gen. Counsel & Secy. | 11/01/2021 | 329,289 |
| Grygiel Nancy A. | SVP & CCO | 05/11/2021 | 406,500 |
| Grygiel Nancy A. | SVP & CCO | 05/11/2021 | 631,273 |
| Williams R Sanders | Director | 05/07/2021 | 62,945 |
| Santos Esteban | EVP, Operations | 05/03/2021 | 164,153 |
| Santos Esteban | EVP, Operations | 05/01/2021 | 156,006 |
| REESE DAVID M | EVP, Research and Development | 05/03/2021 | 178,532 |
| REESE DAVID M | EVP, Research and Development | 05/01/2021 | 265,761 |
| Piacquad David | SVP, Business Development | 05/03/2021 | 52,721 |
| Piacquad David | SVP, Business Development | 05/01/2021 | 33,310 |
| Johnston Lori A | EVP, HR | 05/03/2021 | 80,279 |
| Johnston Lori A | EVP, HR | 05/01/2021 | 85,072 |
| Grygiel Nancy A. | SVP & CCO | 05/03/2021 | 13,180 |
| Grygiel Nancy A. | SVP & CCO | 05/01/2021 | 14,858 |
| Graham Jonathan P | EVP, Gen. Counsel & Secy. | 05/03/2021 | 131,323 |
| Graham Jonathan P | EVP, Gen. Counsel & Secy. | 05/01/2021 | 139,231 |
| Gordon Murdo | EVP Global Commercial Ops | 05/03/2021 | 187,398 |
| Bradway Robert A | Chairman, CEO and President | 05/03/2021 | 682,974 |
| Bradway Robert A | Chairman, CEO and President | 05/01/2021 | 695,435 |
| Santos Esteban | EVP, Operations | 04/27/2021 | 144,113 |
| REESE DAVID M | EVP, Research and Development | 04/27/2021 | 44,460 |
| Piacquad David | SVP, Business Development | 04/27/2021 | 32,707 |
| Louie Linda H. | VP, Finance & CAO | 04/27/2021 | 4,088 |
| Johnston Lori A | EVP, HR | 04/27/2021 | 88,154 |
| Grygiel Nancy A. | SVP & CCO | 04/27/2021 | 14,565 |
| Graham Jonathan P | EVP, Gen. Counsel & Secy. | 04/27/2021 | 144,113 |
| SUGAR RONALD D | Director | 04/14/2021 | 71,640 |
| SUGAR RONALD D | Director | 04/14/2021 | 249,980 |
| Santos Esteban | EVP, Operations | 03/19/2021 | 1,065,671 |
| REESE DAVID M | EVP, Research and Development | 03/19/2021 | 342,432 |
| Piacquad David | SVP, Business Development | 03/19/2021 | 242,220 |
| Louie Linda H. | VP, Finance & CAO | 03/19/2021 | 28,108 |
| Johnston Lori A | EVP, HR | 03/19/2021 | 685,109 |
| Grygiel Nancy A. | SVP & CCO | 03/19/2021 | 106,323 |
| Graham Jonathan P | EVP, Gen. Counsel & Secy. | 03/19/2021 | 1,065,671 |
| Gordon Murdo | EVP Global Commercial Ops | 03/19/2021 | 2,197,091 |
| Bradway Robert A | Chairman, CEO and President | 03/19/2021 | 5,179,260 |
| SUGAR RONALD D | Director | 03/10/2021 | 71,640 |
| SUGAR RONALD D | Director | 03/10/2021 | 231,530 |
| Bradway Robert A | Chairman, CEO and President | 02/18/2021 | 11,197,836 |
| Bradway Robert A | Chairman, CEO and President | 02/18/2021 | 4,019,715 |
| REESE DAVID M | EVP, Research and Development | 02/16/2021 | 272,080 |
| REESE DAVID M | EVP, Research and Development | 02/16/2021 | 125,787 |
| SUGAR RONALD D | Director | 02/10/2021 | 71,640 |
| SUGAR RONALD D | Director | 02/10/2021 | 238,400 |
| Johnston Lori A | EVP, HR | 02/07/2021 | 112,016 |
| Williams R Sanders | Director | 02/08/2021 | 59,498 |
| Graham Jonathan P | EVP, Gen. Counsel & Secy. | 02/04/2021 | 2,627,626 |
| SUGAR RONALD D | Director | 01/13/2021 | 71,640 |
| SUGAR RONALD D | Director | 01/13/2021 | 235,990 |
| Williams R Sanders | Director | 11/09/2020 | 60,600 |
| REESE DAVID M | EVP, Research and Development | 11/02/2020 | 460,998 |
| Gordon Murdo | EVP Global Commercial Ops | 11/02/2020 | 1,359,997 |
| SUGAR RONALD D | Director | 08/19/2020 | 54,690 |
| SUGAR RONALD D | Director | 08/19/2020 | 241,020 |
| Williams R Sanders | Director | 08/07/2020 | 60,737 |
| Santos Esteban | EVP, Operations | 08/01/2020 | 529,711 |
| Grygiel Nancy A. | SVP & CCO | 08/03/2020 | 70,954 |
| SUGAR RONALD D | Director | 07/22/2020 | 54,690 |
| SUGAR RONALD D | Director | 07/22/2020 | 259,790 |
| SUGAR RONALD D | Director | 06/17/2020 | 54,690 |
| SUGAR RONALD D | Director | 06/17/2020 | 228,540 |
| SUGAR RONALD D | Director | 05/20/2020 | 54,690 |
| SUGAR RONALD D | Director | 05/20/2020 | 229,270 |
| Williams R Sanders | Director | 05/06/2020 | 100,857 |
| Santos Esteban | EVP, Operations | 05/03/2020 | 44,810 |
| Santos Esteban | EVP, Operations | 05/01/2020 | 141,857 |
| REESE DAVID M | EVP, Research and Development | 05/03/2020 | 42,731 |
| REESE DAVID M | EVP, Research and Development | 05/01/2020 | 250,224 |
| Piacquad David | SVP, Business Development | 05/03/2020 | 31,413 |
| Piacquad David | SVP, Business Development | 05/01/2020 | 29,424 |
| Patton Cynthia M | SVP & CCO | 05/03/2020 | 29,334 |
| Patton Cynthia M | SVP & CCO | 05/01/2020 | 27,510 |
| Johnston Lori A | EVP, HR | 05/01/2020 | 80,139 |
| Graham Jonathan P | EVP, Gen. Counsel & Secy. | 05/01/2020 | 131,332 |
| Graham Jonathan P | EVP, Gen. Counsel & Secy. | 05/03/2020 | 128,194 |
| Bradway Robert A | Chairman, CEO and President | 05/03/2020 | 637,274 |
| Bradway Robert A | Chairman, CEO and President | 05/01/2020 | 654,745 |
| Santos Esteban | EVP, Operations | 04/27/2020 | 124,283 |
| REESE DAVID M | EVP, Research and Development | 04/27/2020 | 39,695 |
| Piacquad David | SVP, Business Development | 04/27/2020 | 27,408 |
| Patton Cynthia M | SVP & CCO | 04/27/2020 | 24,101 |
| Johnston Lori A | EVP, HR | 04/27/2020 | 79,154 |
| Graham Jonathan P | EVP, Gen. Counsel & Secy. | 04/27/2020 | 129,481 |
| Bradway Robert A | Chairman, CEO and President | 04/27/2020 | 600,860 |
| SUGAR RONALD D | Director | 04/22/2020 | 54,690 |
| SUGAR RONALD D | Director | 04/22/2020 | 233,350 |
| Bradway Robert A | Chairman, CEO and President | 04/13/2020 | 18,374,592 |
| Bradway Robert A | Chairman, CEO and President | 04/13/2020 | 7,420,610 |
| Santos Esteban | EVP, Operations | 03/20/2020 | 1,284,983 |
| REESE DAVID M | EVP, Research and Development | 03/20/2020 | 368,700 |
| Patton Cynthia M | SVP & CCO | 03/20/2020 | 294,364 |
| Piacquad David | SVP, Business Development | 03/20/2020 | 316,227 |
| Johnston Lori A | EVP, HR | 03/20/2020 | 737,201 |
| Graham Jonathan P | EVP, Gen. Counsel & Secy. | 03/20/2020 | 1,152,013 |
| Bradway Robert A | Chairman, CEO and President | 03/20/2020 | 5,529,106 |
| REESE DAVID M | EVP, Research and Development | 03/09/2020 | 164,307 |
| REESE DAVID M | EVP, Research and Development | 03/09/2020 | 86,476 |
| Johnston Lori A | EVP, HR | 02/07/2020 | 106,930 |
| Williams R Sanders | Director | 02/06/2020 | 99,331 |
| Piacquad David | SVP, Business Development | 02/06/2020 | 2,130,081 |
| Piacquad David | SVP, Business Development | 12/13/2019 | 572,276 |
| Piacquad David | SVP, Business Development | 12/13/2019 | 467,475 |
| Meline David W | EVP & CFO | 11/25/2019 | 2,047,603 |
| Graham Jonathan P | EVP, Gen. Counsel & Secy. | 11/22/2019 | 2,074,833 |
| Piacquad David | SVP, Business Development | 11/20/2019 | 1,093,315 |
| Piacquad David | SVP, Business Development | 11/20/2019 | 898,856 |
| Williams R Sanders | Director | 11/06/2019 | 91,566 |
| SUGAR RONALD D | Director | 11/06/2019 | 109,420 |
| SUGAR RONALD D | Director | 11/06/2019 | 430,900 |
| Gordon Murdo | EVP Global Commercial Ops | 11/02/2019 | 1,266,725 |
| SUGAR RONALD D | Director | 10/02/2019 | 109,420 |
| SUGAR RONALD D | Director | 10/02/2019 | 387,160 |
| SUGAR RONALD D | Director | 09/04/2019 | 109,420 |
| SUGAR RONALD D | Director | 09/04/2019 | 413,400 |
| Patton Cynthia M | SVP & CCO | 08/30/2019 | 1,366,331 |
| Patton Cynthia M | SVP & CCO | 08/30/2019 | 2,793,508 |
| Williams R Sanders | Director | 08/07/2019 | 77,792 |
| SUGAR RONALD D | Director | 08/07/2019 | 109,420 |
| SUGAR RONALD D | Director | 08/07/2019 | 366,080 |
| Graham Jonathan P | SVP, Gen. Counsel & Secy. | 08/04/2019 | 1,270,288 |
| Santos Esteban | EVP, Operations | 08/01/2019 | 381,183 |
| SUGAR RONALD D | Director | 07/03/2019 | 109,420 |
| SUGAR RONALD D | Director | 07/03/2019 | 375,160 |
| SUGAR RONALD D | Director | 06/05/2019 | 109,420 |
| SUGAR RONALD D | Director | 06/05/2019 | 351,360 |
| Santos Esteban | EVP, Operations | 05/03/2019 | 32,123 |
| REESE DAVID M | EVP, Research and Development | 05/03/2019 | 30,711 |
| Piacquad David | SVP, Business Development | 05/03/2019 | 32,123 |
| Patton Cynthia M | SVP & CCO | 05/03/2019 | 30,711 |
| Meline David W | EVP & CFO | 05/03/2019 | 140,318 |
| Graham Jonathan P | SVP, Gen. Counsel & Secy. | 05/03/2019 | 92,310 |
| Bradway Robert A | Chairman, CEO and President | 05/03/2019 | 419,894 |
| Piacquad David | SVP, Business Development | 05/01/2019 | 30,664 |
| Santos Esteban | EVP, Operations | 05/01/2019 | 107,056 |
| REESE DAVID M | EVP, Research and Development | 05/01/2019 | 181,834 |
| Patton Cynthia M | SVP & CCO | 05/01/2019 | 29,409 |
| Meline David W | EVP & CFO | 05/01/2019 | 133,775 |
| Johnston Lori A | SVP, HR | 05/01/2019 | 61,149 |
| Graham Jonathan P | SVP, Gen. Counsel & Secy. | 05/01/2019 | 95,400 |
| Bradway Robert A | Chairman, CEO and President | 05/01/2019 | 436,293 |
| SUGAR RONALD D | Director | 05/01/2019 | 109,420 |
| SUGAR RONALD D | Director | 05/01/2019 | 351,460 |
| SUGAR RONALD D | Director | 04/03/2019 | 109,420 |
| SUGAR RONALD D | Director | 04/03/2019 | 386,360 |
| Santos Esteban | EVP, Operations | 03/22/2019 | 352,694 |
| REESE DAVID M | EVP, Research and Development | 03/22/2019 | 339,453 |
| Piacquad David | SVP, Business Development | 03/22/2019 | 289,562 |
| Patton Cynthia M | SVP & CCO | 03/22/2019 | 290,713 |
| Meline David W | EVP & CFO | 03/22/2019 | 1,542,796 |
| Graham Jonathan P | SVP, Gen. Counsel & Secy. | 03/22/2019 | 1,013,755 |
| Bradway Robert A | Chairman, CEO and President | 03/22/2019 | 4,848,677 |
| SUGAR RONALD D | Director | 03/06/2019 | 109,420 |
| SUGAR RONALD D | Director | 03/06/2019 | 377,760 |
| SUGAR RONALD D | Director | 02/07/2019 | 109,420 |
| SUGAR RONALD D | Director | 02/07/2019 | 380,000 |
| Johnston Lori A | SVP, HR | 02/07/2019 | 86,605 |
| Santos Esteban | EVP, Operations | 01/30/2019 | 27,280 |
| REESE DAVID M | EVP, Research and Development | 01/30/2019 | 22,093 |
| Piacquad David | SVP, Business Development | 01/30/2019 | 31,122 |
| Patton Cynthia M | SVP & CCO | 01/30/2019 | 22,477 |
| Meline David W | EVP & CFO | 01/30/2019 | 101,434 |
| Bradway Robert A | Chairman, CEO and President | 01/30/2019 | 312,179 |
| Jacks Tyler | Director | 12/06/2018 | 1,652,000 |
| Jacks Tyler | Director | 12/06/2018 | 3,908,240 |
| Piacquad David | SVP, Business Development | 11/30/2018 | 831,538 |
| Piacquad David | SVP, Business Development | 11/30/2018 | 355,485 |
| Patton Cynthia M | SVP & CCO | 11/29/2018 | 97,184 |
| Patton Cynthia M | SVP & CCO | 11/29/2018 | 360,520 |
| HENDERSON REBECCA M | Director | 08/10/2018 | 189,509 |
| HENDERSON REBECCA M | Director | 08/10/2018 | 189,330 |
| Graham Jonathan P | SVP, Gen. Counsel & Secy. | 08/06/2018 | 1,303,962 |
| Santos Esteban | EVP, Operations | 08/01/2018 | 389,562 |
| Meline David W | EVP & CFO | 08/01/2018 | 1,450,932 |
| Harper Sean E | EVP, Research & Development | 07/16/2018 | 298,458 |
| Harper Sean E | EVP, Research & Development | 06/12/2018 | 281,012 |
| Piacquad David | SVP, Business Development | 05/11/2018 | 1,683,792 |
| Piacquad David | SVP, Business Development | 05/11/2018 | 820,650 |
| Harper Sean E | EVP, Research & Development | 05/14/2018 | 265,503 |
| Santos Esteban | EVP, Operations | 05/03/2018 | 30,159 |
| Piacquad David | SVP, Business Development | 05/03/2018 | 30,159 |
| Patton Cynthia M | SVP & CCO | 05/03/2018 | 28,634 |
| Meline David W | EVP & CFO | 05/03/2018 | 130,969 |
| HOOPER ANTHONY C | EVP, Global Commercial Ops. | 05/03/2018 | 149,607 |
| Harper Sean E | EVP, Research & Development | 05/03/2018 | 124,700 |
| Graham Jonathan P | SVP, Gen. Counsel & Secy. | 05/03/2018 | 66,078 |
| Bradway Robert A | Chairman, CEO and President | 05/03/2018 | 391,722 |
| de Carbonnel Francois | Director | 04/27/2018 | 45,596 |
| Piacquad David | SVP, Business Development | 04/25/2018 | 37,311 |
| Harper Sean E | EVP, Research & Development | 04/12/2018 | 263,337 |
| Santos Esteban | EVP, Operations | 03/23/2018 | 287,715 |
| Piacquad David | SVP, Business Development | 03/23/2018 | 267,466 |
| Patton Cynthia M | SVP & CCO | 03/23/2018 | 221,333 |
| Meline David W | EVP & CFO | 03/23/2018 | 1,329,228 |
| HOOPER ANTHONY C | EVP, Global Commercial Ops. | 03/23/2018 | 1,550,737 |
| Harper Sean E | EVP, Research & Development | 03/23/2018 | 1,329,228 |
| Bradway Robert A | Chairman, CEO and President | 03/23/2018 | 4,519,269 |
| Harper Sean E | EVP, Research & Development | 03/16/2018 | 289,369 |
| Harper Sean E | EVP, Research & Development | 02/14/2018 | 265,624 |
| Johnston Lori A | SVP, HR | 02/07/2018 | 77,903 |
| Santos Esteban | EVP, Operations | 01/31/2018 | 26,969 |
| Santos Esteban | EVP, Operations | 01/30/2018 | 26,334 |
| Patton Cynthia M | SVP & CCO | 01/30/2018 | 21,582 |
| Patton Cynthia M | SVP & CCO | 01/31/2018 | 25,248 |
| HOOPER ANTHONY C | EVP, Global Commercial Ops. | 01/31/2018 | 124,517 |
| HOOPER ANTHONY C | EVP, Global Commercial Ops. | 01/30/2018 | 113,850 |
| Harper Sean E | EVP, Research & Development | 01/31/2018 | 115,910 |
| Harper Sean E | EVP, Research & Development | 01/30/2018 | 89,694 |
| Bradway Robert A | Chairman, CEO and President | 01/30/2018 | 303,534 |
| Bradway Robert A | Chairman, CEO and President | 01/31/2018 | 500,362 |
| Piacquad David | SVP, Business Development | 01/30/2018 | 30,294 |
| Meline David W | EVP & CFO | 01/30/2018 | 98,208 |
| Harper Sean E | EVP, Research & Development | 01/16/2018 | 283,070 |
| Harper Sean E | EVP, Research & Development | 12/12/2017 | 269,666 |
| Harper Sean E | EVP, Research & Development | 11/13/2017 | 261,660 |
| de Carbonnel Francois | Director | 11/08/2017 | 694,420 |
| Harper Sean E | EVP, Research & Development | 10/09/2017 | 283,574 |
| Graham Jonathan P | SVP, Gen. Counsel & Secy. | 08/04/2017 | 1,175,192 |
| Santos Esteban | EVP, Operations | 08/02/2017 | 111,269 |
| Meline David W | EVP & CFO | 08/01/2017 | 1,319,645 |
| BALTIMORE DAVID | Director | 05/31/2017 | 569,541 |
| Patton Cynthia M | SVP & CCO | 05/24/2017 | 451,163 |
| de Carbonnel Francois | Director | 05/01/2017 | 56,019 |
| Santos Esteban | EVP, Operations | 04/26/2017 | 31,458 |
| Such Annette Louise | VP, Finance and CAO | 04/26/2017 | 7,247 |
| Such Annette Louise | VP, Finance and CAO | 04/25/2017 | 6,526 |
| Piacquad David | SVP, Business Development | 04/26/2017 | 458,360 |
| Piacquad David | SVP, Business Development | 04/25/2017 | 35,075 |
| Such Annette Louise | VP, Finance and CAO | 04/24/2017 | 31,120 |
| Such Annette Louise | VP, Finance and CAO | 03/24/2017 | 88,499 |
| Santos Esteban | EVP, Operations | 03/24/2017 | 384,051 |
| Piacquad David | SVP, Business Development | 03/24/2017 | 419,749 |
| Patton Cynthia M | SVP & CCO | 03/24/2017 | 314,314 |
| MCNAMEE BRIAN M | EVP | 03/24/2017 | 1,862,803 |
| HOOPER ANTHONY C | EVP, Global Commercial Ops. | 03/24/2017 | 2,013,733 |
| Harper Sean E | EVP, Research & Development | 03/24/2017 | 2,013,733 |
| Bradway Robert A | Chairman, CEO and President | 03/24/2017 | 6,041,199 |
| Bradway Robert A | Chairman, CEO and President | 01/31/2017 | 429,315 |
| HOOPER ANTHONY C | EVP, Global Commercial Ops. | 01/31/2017 | 103,159 |
| Harper Sean E | EVP, Research & Development | 01/31/2017 | 103,159 |
| Patton Cynthia M | SVP & CCO | 01/31/2017 | 21,002 |
| MCNAMEE BRIAN M | EVP | 01/31/2017 | 90,342 |
| Santos Esteban | EVP, Operations | 01/31/2017 | 23,473 |
| Santos Esteban | EVP, Operations | 01/30/2017 | 22,002 |
| MCNAMEE BRIAN M | EVP | 01/30/2017 | 70,565 |
| MCNAMEE BRIAN M | EVP | 01/28/2017 | 91,467 |
| Piacquad David | SVP, Business Development | 01/30/2017 | 25,146 |
| Meline David W | EVP & CFO | 01/30/2017 | 83,138 |
| Bradway Robert A | Chairman, CEO and President | 01/30/2017 | 379,856 |
| Bradway Robert A | Chairman, CEO and President | 01/28/2017 | 420,089 |
| HOOPER ANTHONY C | EVP, Global Commercial Ops. | 01/30/2017 | 93,982 |
| HOOPER ANTHONY C | EVP, Global Commercial Ops. | 01/28/2017 | 165,489 |
| Harper Sean E | EVP, Research & Development | 01/30/2017 | 80,623 |
| Harper Sean E | EVP, Research & Development | 01/28/2017 | 165,961 |
| Patton Cynthia M | SVP & CCO | 01/28/2017 | 43,848 |
| Patton Cynthia M | SVP & CCO | 01/30/2017 | 17,759 |
| Patton Cynthia M | SVP & CCO | 10/26/2016 | 164,684 |
| MCNAMEE BRIAN M | EVP | 10/25/2016 | 334,825 |
| de Carbonnel Francois | Director | 09/09/2016 | 445,206 |
| de Carbonnel Francois | Director | 09/09/2016 | 358,200 |
| Graham Jonathan P | SVP, Gen. Counsel & Secy. | 08/04/2016 | 1,139,435 |
| Meline David W | EVP & CFO | 08/01/2016 | 1,163,955 |
| Such Annette Louise | VP, Finance and CAO | 08/01/2016 | 44,384 |
| Such Annette Louise | VP, Finance and CAO | 08/02/2016 | 523,758 |
| Balachandran Madhavan | EVP, Operations | 05/04/2016 | 4,623,630 |
| de Carbonnel Francois | Director | 05/03/2016 | 48,810 |
| Harper Sean E | EVP, Research & Development | 04/29/2016 | 3,456,141 |
| BALTIMORE DAVID | Director | 04/29/2016 | 520,683 |
| Patton Cynthia M | SVP & CCO | 04/27/2016 | 37,456 |
| MCNAMEE BRIAN M | EVP | 04/27/2016 | 133,211 |
| HOOPER ANTHONY C | EVP, Global Commercial Ops. | 04/27/2016 | 270,168 |
| Harper Sean E | EVP, Research & Development | 04/27/2016 | 270,168 |
| Bradway Robert A | Chairman, CEO and President | 04/27/2016 | 653,354 |
| Balachandran Madhavan | EVP, Operations | 04/27/2016 | 75,237 |
| Tross Stuart A | SVP, Human Resources | 04/27/2016 | 41,364 |
| Tross Stuart A | SVP, Human Resources | 04/26/2016 | 29,586 |
| Piacquad David | SVP, Business Development | 04/27/2016 | 47,064 |
| Piacquad David | SVP, Business Development | 04/26/2016 | 25,173 |
| Such Annette Louise | VP, Finance and CAO | 04/26/2016 | 6,702 |
| Piacquad David | SVP, Business Development | 04/25/2016 | 34,270 |
| Such Annette Louise | VP, Finance and CAO | 04/25/2016 | 6,364 |
| BALTIMORE DAVID | Director | 03/30/2016 | 252,339 |
| BALTIMORE DAVID | Director | 03/30/2016 | 252,200 |
| Tross Stuart A | SVP, Human Resources | 03/25/2016 | 403,396 |
| Such Annette Louise | VP, Finance and CAO | 03/25/2016 | 108,796 |
| Piacquad David | SVP, Business Development | 03/25/2016 | 344,297 |
| Patton Cynthia M | SVP & CCO | 03/25/2016 | 948,271 |
| MCNAMEE BRIAN M | EVP | 03/25/2016 | 2,091,748 |
| HOOPER ANTHONY C | EVP, Global Commercial Ops. | 03/25/2016 | 3,549,674 |
| Harper Sean E | EVP, Research & Development | 03/25/2016 | 3,549,674 |
| Bradway Robert A | Chairman, CEO and President | 03/25/2016 | 8,874,408 |
| Balachandran Madhavan | EVP, Operations | 03/25/2016 | 3,549,674 |
| HERRINGER FRANK C | Director | 03/14/2016 | 252,275 |
| HERRINGER FRANK C | Director | 03/14/2016 | 252,200 |
| COFFMAN VANCE D | Director | 03/09/2016 | 252,235 |
| COFFMAN VANCE D | Director | 03/09/2016 | 252,200 |
| Bradway Robert A | Chairman, CEO and President | 03/02/2016 | 6,499,334 |
| Bradway Robert A | Chairman, CEO and President | 03/02/2016 | 4,236,960 |
| Bradway Robert A | Chairman, CEO and President | 03/02/2016 | 2,929,560 |
| Tross Stuart A | SVP, Human Resources | 01/31/2016 | 38,335 |
| Patton Cynthia M | SVP & CCO | 01/31/2016 | 21,229 |
| Patton Cynthia M | SVP & CCO | 01/28/2016 | 46,345 |
| MCNAMEE BRIAN M | EVP | 01/31/2016 | 87,056 |
| MCNAMEE BRIAN M | EVP | 01/28/2016 | 82,909 |
| HOOPER ANTHONY C | EVP, Global Commercial Ops. | 01/31/2016 | 99,427 |
| HOOPER ANTHONY C | EVP, Global Commercial Ops. | 01/28/2016 | 149,718 |
| Harper Sean E | EVP, Research & Development | 01/28/2016 | 150,320 |
| Harper Sean E | EVP, Research & Development | 01/31/2016 | 99,427 |
| Bradway Robert A | Chairman, CEO and President | 01/31/2016 | 410,996 |
| Bradway Robert A | Chairman, CEO and President | 01/28/2016 | 369,103 |
| Balachandran Madhavan | EVP, Operations | 01/31/2016 | 87,056 |
| Balachandran Madhavan | EVP, Operations | 01/28/2016 | 139,185 |
| Tross Stuart A | SVP, Human Resources | 10/25/2015 | 88,622 |
| Patton Cynthia M | SVP & CCO | 10/26/2015 | 153,725 |
| MCNAMEE BRIAN M | EVP | 10/25/2015 | 311,344 |
| de Carbonnel Francois | Director | 08/31/2015 | 769,190 |
| Hassan Fred | Director | 08/19/2015 | 501,563 |
| Such Annette Louise | CAO | 07/31/2015 | 280,026 |
| Meline David W | EVP & CFO | 08/01/2015 | 1,270,742 |
| Balachandran Madhavan | EVP, Operations | 07/31/2015 | 831,838 |
| PELHAM JUDITH C | Director | 07/31/2015 | 908,314 |
| Patton Cynthia M | SVP & CCO | 06/02/2015 | 711,482 |
| Balachandran Madhavan | EVP, Operations | 05/07/2015 | 1,211,947 |
| Balachandran Madhavan | EVP, Operations | 05/07/2015 | 3,433,691 |
| Tross Stuart A | SVP, Human Resources | 04/27/2015 | 40,634 |
| Tross Stuart A | SVP, Human Resources | 04/26/2015 | 29,552 |
| Tross Stuart A | SVP, Human Resources | 04/25/2015 | 53,395 |
| Such Annette Louise | CAO | 04/26/2015 | 6,716 |
| SCOTT DAVID J | SVP, Gen. Counsel & Secy. | 04/27/2015 | 179,496 |
| SCOTT DAVID J | SVP, Gen. Counsel & Secy. | 04/25/2015 | 318,693 |
| Piacquad David | SVP, Business Development | 04/25/2015 | 55,410 |
| Piacquad David | SVP, Business Development | 04/27/2015 | 46,007 |
| Piacquad David | SVP, Business Development | 04/26/2015 | 444,626 |
| Patton Cynthia M | SVP & CCO | 04/25/2015 | 44,664 |
| Patton Cynthia M | SVP & CCO | 04/27/2015 | 36,772 |
| MCNAMEE BRIAN M | EVP | 04/27/2015 | 130,466 |
| MCNAMEE BRIAN M | EVP | 04/25/2015 | 213,414 |
| Bradway Robert A | Chairman, CEO and President | 04/27/2015 | 639,737 |
| Bradway Robert A | Chairman, CEO and President | 04/25/2015 | 625,633 |
| Harper Sean E | EVP, Research & Development | 04/27/2015 | 264,458 |
| Harper Sean E | EVP, Research & Development | 04/25/2015 | 178,824 |
| HOOPER ANTHONY C | EVP, Global Commercial Ops. | 04/27/2015 | 264,458 |
| Balachandran Madhavan | EVP, Operations | 04/25/2015 | 128,115 |
| Balachandran Madhavan | EVP, Operations | 04/27/2015 | 73,545 |
| de Carbonnel Francois | Director | 04/24/2015 | 38,119 |
| Tross Stuart A | SVP, Human Resources | 04/23/2015 | 509,965 |
| Harper Sean E | EVP, Research & Development | 04/22/2015 | 4,804,240 |
| Tross Stuart A | SVP, Human Resources | 03/27/2015 | 595,801 |
| SCOTT DAVID J | SVP, Gen. Counsel & Secy. | 03/27/2015 | 3,261,413 |
| Piacquad David | SVP, Business Development | 03/27/2015 | 706,741 |
| Patton Cynthia M | SVP & CCO | 03/27/2015 | 561,925 |
| MCNAMEE BRIAN M | EVP | 03/27/2015 | 2,330,704 |
| HOOPER ANTHONY C | EVP, Global Commercial Ops. | 03/27/2015 | 4,595,583 |
| Harper Sean E | EVP, Research & Development | 03/27/2015 | 4,595,583 |
| Bradway Robert A | Chairman, CEO and President | 03/27/2015 | 11,118,569 |
| Balachandran Madhavan | EVP, Operations | 03/27/2015 | 1,334,331 |
| HOOPER ANTHONY C | EVP, Global Commercial Ops. | 03/11/2015 | 4,229,593 |
| Tross Stuart A | SVP, Human Resources | 03/03/2015 | 696,427 |
| BALTIMORE DAVID | Director | 03/02/2015 | 579,012 |
| HOOPER ANTHONY C | EVP, Global Commercial Ops. | 03/02/2015 | 507,070 |
| BALTIMORE DAVID | Director | 02/19/2015 | 210,770 |
| BALTIMORE DAVID | Director | 02/19/2015 | 210,650 |
| Bradway Robert A | Chairman, CEO and President | 02/11/2015 | 6,185,036 |
| Bradway Robert A | Chairman, CEO and President | 02/11/2015 | 3,538,920 |
| Bradway Robert A | Chairman, CEO and President | 02/11/2015 | 3,359,114 |
| COFFMAN VANCE D | Director | 02/06/2015 | 210,717 |
| COFFMAN VANCE D | Director | 02/06/2015 | 210,650 |
| HERRINGER FRANK C | Director | 02/05/2015 | 210,667 |
| HERRINGER FRANK C | Director | 02/05/2015 | 210,650 |
| HERRINGER FRANK C | Director | 02/05/2015 | 228,435 |
| HERRINGER FRANK C | Director | 02/05/2015 | 228,435 |
| SCOTT DAVID J | SVP, Gen. Counsel & Secy. | 01/28/2015 | 103,120 |
| Patton Cynthia M | SVP & CCO | 01/28/2015 | 46,714 |
| MCNAMEE BRIAN M | EVP | 01/28/2015 | 85,483 |
| HOOPER ANTHONY C | EVP, Global Commercial Ops. | 01/28/2015 | 152,376 |
| Harper Sean E | EVP, Research & Development | 01/28/2015 | 153,011 |
| Bradway Robert A | Chairman, CEO and President | 01/28/2015 | 384,196 |
| Balachandran Madhavan | EVP, Operations | 01/28/2015 | 143,637 |
| SCOTT DAVID J | SVP, Gen. Counsel & Secy. | 12/31/2014 | 1,850,779 |
| MCNAMEE BRIAN M | EVP | 12/31/2014 | 1,850,779 |
| Harper Sean E | EVP, Research & Development | 12/31/2014 | 2,095,579 |
| de Carbonnel Francois | Director | 12/03/2014 | 504,041 |
| Patton Cynthia M | SVP & CCO | 10/28/2014 | 77,360 |
| MCNAMEE BRIAN M | EVP | 10/25/2014 | 288,924 |
| Patton Cynthia M | SVP & CCO | 10/26/2014 | 142,548 |
| COFFMAN VANCE D | Director | 09/05/2014 | 1,135,822 |
| COFFMAN VANCE D | Director | 09/05/2014 | 1,135,800 |
| Tross Stuart A | SVP, Human Resources | 09/01/2014 | 1,016,359 |
| Harper Sean E | EVP, Research & Development | 08/05/2014 | 1,782,130 |
| Patton Cynthia M | SVP & CCO | 08/05/2014 | 148,041 |
| Patton Cynthia M | SVP & CCO | 08/05/2014 | 338,358 |
| de Carbonnel Francois | Director | 08/05/2014 | 317,894 |
| de Carbonnel Francois | Director | 08/05/2014 | 273,450 |
| Balachandran Madhavan | EVP, Operations | 07/31/2014 | 618,588 |
| Michael A Kelly | Acting CFO | 06/30/2014 | 227,574 |
| Dittrich Thomas J.W. | VP, Finance & CAO | 05/21/2014 | 233,911 |
| Dittrich Thomas J.W. | VP, Finance & CAO | 05/21/2014 | 465,984 |
| Bradway Robert A | Chairman, CEO and President | 05/12/2014 | 99,920 |
| Tross Stuart A | SVP, Human Resources | 04/26/2014 | 15,263 |
| Tross Stuart A | SVP, Human Resources | 04/25/2014 | 25,246 |
| Tross Stuart A | SVP, Human Resources | 04/27/2014 | 19,051 |
| SCOTT DAVID J | SVP, Gen. Counsel & Secy. | 04/27/2014 | 116,758 |
| SCOTT DAVID J | SVP, Gen. Counsel & Secy. | 04/26/2014 | 80,549 |
| SCOTT DAVID J | SVP, Gen. Counsel & Secy. | 04/25/2014 | 209,472 |
| Piacquad David | SVP, Business Development | 04/27/2014 | 29,969 |
| Piacquad David | SVP, Business Development | 04/25/2014 | 36,390 |
| Patton Cynthia M | SVP & CCO | 04/27/2014 | 21,168 |
| Patton Cynthia M | SVP & CCO | 04/26/2014 | 5,571 |
| Patton Cynthia M | SVP & CCO | 04/25/2014 | 21,152 |
| MCNAMEE BRIAN M | EVP | 04/27/2014 | 84,894 |
| MCNAMEE BRIAN M | EVP | 04/26/2014 | 80,549 |
| MCNAMEE BRIAN M | EVP | 04/25/2014 | 140,330 |
| Michael A Kelly | Acting CFO | 04/27/2014 | 16,266 |
| Michael A Kelly | Acting CFO | 04/26/2014 | 12,924 |
| Michael A Kelly | Acting CFO | 04/25/2014 | 19,787 |
| Michael A Kelly | Acting CFO | 04/28/2014 | 228,073 |
| HOOPER ANTHONY C | EVP, Global Commercial Ops. | 04/27/2014 | 172,240 |
| Harper Sean E | EVP, Research & Development | 04/26/2014 | 66,957 |
| Harper Sean E | EVP, Research & Development | 04/25/2014 | 117,586 |
| Harper Sean E | EVP, Research & Development | 04/27/2014 | 172,240 |
| Dittrich Thomas J.W. | VP, Finance & CAO | 04/27/2014 | 29,524 |
| Dittrich Thomas J.W. | VP, Finance & CAO | 04/26/2014 | 18,940 |
| Dittrich Thomas J.W. | VP, Finance & CAO | 04/25/2014 | 35,481 |
| Balachandran Madhavan | EVP, Operations | 04/25/2014 | 84,153 |
| Balachandran Madhavan | EVP, Operations | 04/27/2014 | 47,795 |
| Balachandran Madhavan | EVP, Operations | 04/26/2014 | 48,686 |
| Bradway Robert A | Chairman, CEO and President | 04/27/2014 | 416,785 |
| Bradway Robert A | Chairman, CEO and President | 04/26/2014 | 261,702 |
| Bradway Robert A | Chairman, CEO and President | 04/25/2014 | 411,325 |
| de Carbonnel Francois | Director | 04/25/2014 | 61,295 |
| Tross Stuart A | SVP, Human Resources | 03/14/2014 | 204,162 |
| SCOTT DAVID J | SVP, Gen. Counsel & Secy. | 03/14/2014 | 1,769,901 |
| Patton Cynthia M | SVP & CCO | 03/14/2014 | 170,693 |
| MCNAMEE BRIAN M | EVP | 03/14/2014 | 1,166,588 |
| Michael A Kelly | Acting CFO | 03/14/2014 | 170,693 |
| Harper Sean E | EVP, Research & Development | 03/14/2014 | 952,385 |
| Dittrich Thomas J.W. | VP, Finance & CAO | 03/14/2014 | 287,091 |
| Bradway Robert A | Chairman, CEO and President | 03/14/2014 | 3,333,408 |
| Balachandran Madhavan | EVP, Operations | 03/14/2014 | 714,381 |
| HOOPER ANTHONY C | EVP, Global Commercial Ops. | 03/12/2014 | 3,422,396 |
| de Carbonnel Francois | Director | 03/06/2014 | 759,790 |
| de Carbonnel Francois | Director | 03/06/2014 | 544,350 |
| de Carbonnel Francois | Director | 03/06/2014 | 126,690 |
| HOOPER ANTHONY C | EVP, Global Commercial Ops. | 03/02/2014 | 934,739 |
| BALTIMORE DAVID | Director | 02/26/2014 | 312,765 |
| BALTIMORE DAVID | Director | 02/26/2014 | 312,750 |
| HERRINGER FRANK C | Director | 02/25/2014 | 312,840 |
| HERRINGER FRANK C | Director | 02/25/2014 | 312,750 |
| HENDERSON REBECCA M | Director | 02/13/2014 | 1,248,160 |
| HENDERSON REBECCA M | Director | 02/13/2014 | 2,470,680 |
| Bradway Robert A | Chairman, CEO and President | 02/12/2014 | 5,714,647 |
| Bradway Rob |