Alnylam Pharmaceuticals, Inc. (ALNY) NASDAQ
$246.78 (4.70) (-1.87%)
Market Cap: $31.68B
As of 09/06/24 04:00 PM EDT. Market closed.
Alnylam Pharmaceuticals, Inc. (ALNY)
NASDAQ
$246.78
(4.70) (-1.87%)
Market Cap: $31.68B
As of 09/06/24 04:00 PM EDT. Market closed.
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Alnylam Pharmaceuticals, Inc., a biopharmaceutical company, focuses on discovering, developing, and commercializing novel therapeutics based on ribonucleic acid interference. The company's pipeline of investigational RNAi therapeutics focuses on genetic medicines, cardio-metabolic diseases, hepatic infectious diseases, and central nervous system (CNS)/ocular diseases. Its marketed products ... read more
COMPANY PROFILE
Sector
Healthcare
Industry
Biotechnology
CEO
Dr. Yvonne L. Greenstreet M.B.A., MBChB
Full Time Employees
2,100
CEO Compensation (Base)
$975,800
CEO Compensation (Total)
$8.90M
Sector
Healthcare
Industry
Biotechnology
CEO
Dr. Yvonne L. Greenstreet M.B.A., MBChB
Full Time Employees
2,100
CEO Compensation (Base)
$975,800
CEO Compensation (Total)
$8.90M
URL
Address
675 West Kendall Street, MA, Cambridge, 02142.
PRICE CHART FOR ALNYLAM PHARMACEUTICALS, INC.
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NEWS
INSIDEARBITRAGE ARTICLES
KEY STATS
Open
$252.35
Previous Close
$251.48
Days Range
$244.88 - $253.44
52 week range
$141.98 - $287.55
Volume
669,840
Avg. Volume (30 days)
1,227,103
Market Cap
$31.68B
Dividend Yield
-
P/E
(448.69)
Shares Outstanding
128,381,000
Open
$252.35
Previous Close
$251.48
Days Range
$244.88 - $253.44
52 week range
$141.98 - $287.55
Volume
669,840
Avg. Volume (30 days)
1,227,103
Market Cap
$31.68B
Dividend Yield
-
P/E
(448.69)
Shares Outstanding
128,381,000
FINANCIAL STATEMENTS FOR ALNYLAM PHARMACEUTICALS, INC.
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INSIDER TRANSACTIONS FOR ALNYLAM PHARMACEUTICALS, INC.
| Owner | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| Greenstreet Yvonne | Chief Executive Officer | Aug 20, 2024 | Option Exercise | $85.00 | 15,000 | 1,275,000 | 88,441 | Aug 22, 2024, 08:01 PM |
| Greenstreet Yvonne | Chief Executive Officer | Aug 20, 2024 | Sale | $280.00 | 15,000 | 4,200,000 | 73,441 | Aug 22, 2024, 08:01 PM |
| Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Aug 12, 2024 | Option Exercise | $89.09 | 20,725 | 1,846,429 | 34,906 | Aug 14, 2024, 04:12 PM |
| Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Aug 12, 2024 | Sale | $270.99 | 22,025 | 5,968,516 | 33,485 | Aug 14, 2024, 04:12 PM |
| Ausiello Dennis A | Director | Aug 06, 2024 | Option Exercise | $119.68 | 20,250 | 2,423,453 | 20,386 | Aug 08, 2024, 04:10 PM |
| Ausiello Dennis A | Director | Aug 06, 2024 | Sale | $262.00 | 20,250 | 5,305,587 | 18,759 | Aug 08, 2024, 04:10 PM |
| Greenstreet Yvonne | Chief Executive Officer | Aug 01, 2024 | Option Exercise | $85.00 | 15,148 | 1,287,580 | 88,589 | Aug 02, 2024, 08:01 PM |
| Greenstreet Yvonne | Chief Executive Officer | Aug 01, 2024 | Sale | $270.00 | 15,148 | 4,089,960 | 73,441 | Aug 02, 2024, 08:01 PM |
| Greenstreet Yvonne | Chief Executive Officer | Jul 11, 2024 | Sale | $261.00 | 7,093 | 1,851,273 | 73,441 | Jul 12, 2024, 08:02 PM |
| SCHULMAN AMY W | Director | Jun 25, 2024 | Option Exercise | $131.21 | 8,500 | 1,115,285 | 16,936 | Jun 27, 2024, 04:04 PM |
| SCHULMAN AMY W | Director | Jun 25, 2024 | Sale | $240.00 | 8,500 | 2,040,000 | 8,436 | Jun 27, 2024, 04:04 PM |
| PYOTT DAVID E I | Director | Jun 24, 2024 | Option Exercise | $80.76 | 32,450 | 2,620,611 | 32,586 | Jun 26, 2024, 04:28 PM |
| PYOTT DAVID E I | Director | Jun 24, 2024 | Sale | $220.69 | 32,450 | 7,161,360 | 15,026 | Jun 26, 2024, 04:28 PM |
| Garg Pushkal | CMO & EVP Dev & Med Affairs | Jun 25, 2024 | Sale | $230.99 | 2,103 | 485,773 | 17,634 | Jun 26, 2024, 04:28 PM |
| Greenstreet Yvonne | Chief Executive Officer | Jun 25, 2024 | Sale | $230.99 | 8,301 | 1,917,475 | 88,527 | Jun 26, 2024, 04:27 PM |
| Poulton Jeffrey V. | EVP, Chief Financial Officer | Jun 25, 2024 | Sale | $231.00 | 1,605 | 370,747 | 30,438 | Jun 26, 2024, 04:26 PM |
| Tanguler Tolga | EVP, Chief Commercial Officer | Jun 25, 2024 | Sale | $231.00 | 1,605 | 370,747 | 13,206 | Jun 26, 2024, 04:26 PM |
| Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Jun 25, 2024 | Sale | $230.99 | 1,198 | 276,731 | 15,334 | Jun 26, 2024, 04:26 PM |
| SCHULMAN AMY W | Director | May 29, 2024 | Option Exercise | $66.83 | 30,000 | 2,004,900 | 30,136 | May 31, 2024, 07:00 PM |
| SCHULMAN AMY W | Director | May 29, 2024 | Sale | $148.60 | 21,700 | 3,224,546 | 20,015 | May 31, 2024, 07:00 PM |
| SHARP PHILLIP A | Director | Feb 29, 2024 | Option Exercise | $59.25 | 30,000 | 1,777,500 | 30,000 | Mar 01, 2024, 04:12 PM |
| SHARP PHILLIP A | Director | Feb 29, 2024 | Sale | $151.34 | 30,000 | 4,540,071 | 16,995 | Mar 01, 2024, 04:12 PM |
| Tanguler Tolga | EVP, Chief Commercial Officer | Feb 28, 2024 | Sale | $155.30 | 501 | 77,805 | 5,521 | Feb 29, 2024, 04:18 PM |
| Poulton Jeffrey V. | EVP, Chief Financial Officer | Feb 28, 2024 | Sale | $155.30 | 574 | 89,145 | 19,805 | Feb 29, 2024, 04:18 PM |
| Greenstreet Yvonne | Chief Executive Officer | Feb 28, 2024 | Sale | $155.31 | 2,932 | 455,357 | 49,801 | Feb 29, 2024, 04:18 PM |
| Garg Pushkal | CMO & EVP Dev & Med Affairs | Feb 28, 2024 | Sale | $155.30 | 574 | 89,145 | 8,993 | Feb 29, 2024, 04:17 PM |
| Franchini Indrani Lall | EVP, CLO & Secretary | Feb 28, 2024 | Sale | $155.30 | 329 | 51,094 | 4,320 | Feb 29, 2024, 04:16 PM |
| Garg Pushkal | CMO & EVP Dev & Med Affairs | Feb 16, 2024 | Sale | $148.06 | 1,308 | 193,666 | 8,160 | Feb 20, 2024, 04:09 PM |
| Poulton Jeffrey V. | EVP, Chief Financial Officer | Feb 16, 2024 | Sale | $148.06 | 1,007 | 149,099 | 18,782 | Feb 20, 2024, 04:08 PM |
| Tanguler Tolga | EVP, Chief Commercial Officer | Feb 16, 2024 | Sale | $148.06 | 1,009 | 149,397 | 4,710 | Feb 20, 2024, 04:08 PM |
| Greenstreet Yvonne | Chief Executive Officer | Feb 16, 2024 | Sale | $148.06 | 7,030 | 1,040,885 | 49,593 | Feb 20, 2024, 04:07 PM |
| Franchini Indrani Lall | EVP, CLO & Secretary | Feb 02, 2024 | Sale | $170.99 | 1,591 | 272,050 | 4,673 | Feb 05, 2024, 04:05 PM |
| BONNEY MICHAEL W | Director | Dec 27, 2023 | Option Exercise | $96.45 | 30,000 | 2,893,500 | 46,029 | Dec 29, 2023, 04:03 PM |
| BONNEY MICHAEL W | Director | Dec 27, 2023 | Sale | $195.00 | 30,000 | 5,850,000 | 16,029 | Dec 29, 2023, 04:03 PM |
| Garg Pushkal | CMO & EVP Dev & Med Affairs | Aug 07, 2023 | Sale | $183.89 | 4,166 | 766,083 | 5,399 | Aug 07, 2023, 06:05 PM |
| Garg Pushkal | CMO & EVP Dev & Med Affairs | Aug 04, 2023 | Sale | $185.85 | 3,461 | 643,223 | 11,314 | Aug 07, 2023, 06:05 PM |
| Poulton Jeffrey V. | EVP, Chief Financial Officer | Aug 04, 2023 | Sale | $185.85 | 3,460 | 643,037 | 18,675 | Aug 07, 2023, 06:05 PM |
| Greenstreet Yvonne | Chief Executive Officer | Aug 04, 2023 | Sale | $185.85 | 4,057 | 753,986 | 38,502 | Aug 07, 2023, 06:04 PM |
| Vaishnaw Akshay | President | Aug 04, 2023 | Sale | $185.85 | 4,057 | 753,986 | 26,060 | Aug 07, 2023, 06:04 PM |
| BONNEY MICHAEL W | Director | Aug 03, 2023 | Sale | $185.38 | 6,448 | 1,195,310 | 22,177 | Aug 04, 2023, 04:02 PM |
| Greenstreet Yvonne | Chief Executive Officer | Apr 27, 2023 | Sale | $194.59 | 7,615 | 1,481,811 | 37,319 | Apr 28, 2023, 05:55 PM |
| Poulton Jeffrey V. | EVP, Chief Financial Officer | Apr 27, 2023 | Sale | $194.59 | 977 | 190,113 | 12,602 | Apr 28, 2023, 05:55 PM |
| Tanguler Tolga | EVP, Chief Commercial Officer | Apr 27, 2023 | Sale | $194.59 | 1,476 | 287,215 | 3,155 | Apr 28, 2023, 05:55 PM |
| Vaishnaw Akshay | President | Apr 27, 2023 | Sale | $194.59 | 2,392 | 465,464 | 20,085 | Apr 28, 2023, 05:54 PM |
| Garg Pushkal | CMO & EVP Dev & Med Affairs | Apr 28, 2023 | Sale | $199.02 | 2,455 | 488,595 | 6,596 | Apr 28, 2023, 05:54 PM |
| Garg Pushkal | CMO & EVP Dev & Med Affairs | Apr 27, 2023 | Sale | $194.59 | 1,839 | 357,855 | 8,488 | Apr 28, 2023, 05:54 PM |
| Franchini Indrani Lall | EVP, CLO & Secretary | Apr 06, 2023 | Sale | $210.00 | 3,500 | 735,000 | 0 | Apr 10, 2023, 04:29 PM |
| Garg Pushkal | CMO & EVP Dev & Med Affairs | Mar 03, 2023 | Option Exercise | $96.45 | 5,000 | 482,250 | 22,417 | Mar 07, 2023, 04:07 PM |
| Garg Pushkal | CMO & EVP Dev & Med Affairs | Mar 03, 2023 | Sale | $200.00 | 18,072 | 3,614,400 | 4,345 | Mar 07, 2023, 04:07 PM |
| Franchini Indrani Lall | EVP, CLO & Secretary | Feb 02, 2023 | Sale | $226.01 | 1,675 | 378,563 | 5,098 | Feb 03, 2023, 05:46 PM |
| Tanguler Tolga | EVP, Chief Commercial Officer | Feb 02, 2023 | Sale | $226.01 | 1,601 | 361,839 | 4,952 | Feb 03, 2023, 05:45 PM |
| Tanguler Tolga | EVP, Chief Commercial Officer | Feb 03, 2023 | Sale | $232.14 | 3,424 | 794,854 | 3,296 | Feb 03, 2023, 05:45 PM |
| Vaishnaw Akshay | President | Dec 05, 2022 | Option Exercise | $226.20 | 1,324 | 299,489 | 22,101 | Dec 07, 2022, 04:09 PM |
| Vaishnaw Akshay | President | Dec 05, 2022 | Option Exercise | $59.05 | 5,079 | 299,938 | 23,425 | Dec 07, 2022, 04:09 PM |
| Ausiello Dennis A | Director | Nov 21, 2022 | Option Exercise | $71.09 | 22,500 | 1,599,637 | 22,500 | Nov 23, 2022, 04:05 PM |
| Ausiello Dennis A | Director | Nov 21, 2022 | Sale | $220.00 | 22,500 | 4,950,000 | 0 | Nov 23, 2022, 04:05 PM |
| Tanguler Tolga | EVP, Chief Commercial Officer | Aug 04, 2022 | Option Exercise | $191.73 | 1,788 | 342,817 | 2,011 | Aug 05, 2022, 04:15 PM |
| Tanguler Tolga | EVP, Chief Commercial Officer | Aug 03, 2022 | Sale | $210.00 | 1,754 | 368,340 | 3,629 | Aug 05, 2022, 04:15 PM |
| Tanguler Tolga | EVP, Chief Commercial Officer | Aug 05, 2022 | Sale | $218.16 | 1,841 | 401,630 | 1,692 | Aug 05, 2022, 04:15 PM |
| Poulton Jeffrey V. | EVP, Chief Financial Officer | Aug 04, 2022 | Option Exercise | $191.69 | 5,054 | 968,824 | 9,887 | Aug 05, 2022, 04:14 PM |
| Garg Pushkal | CMO & EVP Dev & Med Affairs | Aug 04, 2022 | Option Exercise | $191.55 | 5,086 | 974,201 | 17,900 | Aug 05, 2022, 04:14 PM |
| Vaishnaw Akshay | President | Aug 04, 2022 | Option Exercise | $191.73 | 6,052 | 1,160,335 | 18,919 | Aug 05, 2022, 04:13 PM |
| Greenstreet Yvonne | Chief Executive Officer | Aug 04, 2022 | Option Exercise | $191.68 | 6,002 | 1,150,439 | 21,564 | Aug 05, 2022, 04:13 PM |
| Tanguler Tolga | EVP, Chief Commercial Officer | Jul 05, 2022 | Sale | $150.00 | 1,754 | 263,100 | 1,754 | Jul 07, 2022, 04:06 PM |
| PAUL STEVEN M | Director | Apr 01, 2022 | Option Exercise | $11.33 | 15,000 | 169,950 | 16,000 | Apr 05, 2022, 04:05 PM |
| PAUL STEVEN M | Director | Apr 01, 2022 | Sale | $170.69 | 15,000 | 2,560,371 | 15,747 | Apr 05, 2022, 04:05 PM |
| SHARP PHILLIP A | Director | Feb 09, 2022 | Option Exercise | $11.33 | 30,000 | 339,900 | 30,000 | Feb 11, 2022, 04:04 PM |
| SHARP PHILLIP A | Director | Feb 09, 2022 | Sale | $150.00 | 30,000 | 4,500,000 | 0 | Feb 11, 2022, 04:04 PM |
| Tanguler Tolga | EVP, Chief Commercial Officer | Feb 02, 2022 | Option Exercise | $144.67 | 1,518 | 219,609 | 3,508 | Feb 03, 2022, 04:10 PM |
| Vaishnaw Akshay | President, R&D | Dec 22, 2021 | Option Exercise | $189.00 | 2,538 | 479,690 | 14,217 | Dec 23, 2021, 05:23 PM |
| Vaishnaw Akshay | President, R&D | Dec 23, 2021 | Sale | $190.93 | 2,879 | 549,698 | 13,970 | Dec 23, 2021, 05:23 PM |
| MARAGANORE JOHN | Chief Executive Officer | Dec 22, 2021 | Option Exercise | $188.98 | 6,636 | 1,254,077 | 227,984 | Dec 23, 2021, 05:00 PM |
| Greenstreet Yvonne | President & COO | Dec 22, 2021 | Option Exercise | $189.01 | 2,538 | 479,699 | 14,025 | Dec 23, 2021, 05:00 PM |
| MARAGANORE JOHN | Chief Executive Officer | Dec 10, 2021 | Option Exercise | $74.50 | 5,367 | 399,829 | 220,132 | Dec 14, 2021, 04:05 PM |
| MARAGANORE JOHN | Chief Executive Officer | Nov 12, 2021 | Option Exercise | $7.10 | 33,978 | 241,244 | 248,743 | Nov 12, 2021, 05:52 PM |
| MARAGANORE JOHN | Chief Executive Officer | Nov 12, 2021 | Sale | $171.52 | 33,978 | 5,827,801 | 238,378 | Nov 12, 2021, 05:52 PM |
| MARAGANORE JOHN | Chief Executive Officer | Aug 13, 2021 | Option Exercise | $7.10 | 33,979 | 241,251 | 248,744 | Aug 16, 2021, 04:38 PM |
| MARAGANORE JOHN | Chief Executive Officer | Aug 13, 2021 | Sale | $199.78 | 33,979 | 6,788,196 | 246,303 | Aug 16, 2021, 04:38 PM |
| Vaishnaw Akshay | President, R&D | Aug 09, 2021 | Option Exercise | $63.00 | 10,834 | 682,542 | 22,049 | Aug 11, 2021, 04:10 PM |
| Vaishnaw Akshay | President, R&D | Aug 09, 2021 | Sale | $200.00 | 10,834 | 2,166,800 | 11,215 | Aug 11, 2021, 04:10 PM |
| KEATING LAURIE | EVP, Chief Legal Officer | Aug 05, 2021 | Option Exercise | $88.95 | 10,000 | 889,500 | 15,132 | Aug 09, 2021, 04:09 PM |
| KEATING LAURIE | EVP, Chief Legal Officer | Aug 05, 2021 | Sale | $188.95 | 10,000 | 1,889,500 | 5,132 | Aug 09, 2021, 04:09 PM |
| Greenstreet Yvonne | President & COO | Aug 06, 2021 | Option Exercise | $77.10 | 53,064 | 4,091,234 | 64,087 | Aug 09, 2021, 04:09 PM |
| Greenstreet Yvonne | President & COO | Aug 06, 2021 | Sale | $199.00 | 53,064 | 10,559,736 | 11,023 | Aug 09, 2021, 04:09 PM |
| KEATING LAURIE | EVP, Chief Legal Officer | Jul 12, 2021 | Option Exercise | $87.90 | 6,812 | 598,770 | 11,944 | Jul 14, 2021, 04:58 PM |
| KEATING LAURIE | EVP, Chief Legal Officer | Jul 12, 2021 | Sale | $178.96 | 6,812 | 1,219,098 | 10,132 | Jul 14, 2021, 04:58 PM |
| MARAGANORE JOHN | Chief Executive Officer | May 13, 2021 | Option Exercise | $7.10 | 33,979 | 241,251 | 248,744 | May 17, 2021, 07:25 PM |
| MARAGANORE JOHN | Chief Executive Officer | May 13, 2021 | Sale | $130.78 | 33,979 | 4,443,725 | 245,729 | May 17, 2021, 07:25 PM |
| KEATING LAURIE | EVP, Chief Legal Officer | Apr 20, 2021 | Option Exercise | $131.85 | 2,089 | 275,426 | 6,941 | Apr 21, 2021, 06:21 PM |
| MARAGANORE JOHN | Chief Executive Officer | Apr 20, 2021 | Option Exercise | $131.85 | 7,507 | 989,822 | 215,035 | Apr 21, 2021, 06:20 PM |
| MARAGANORE JOHN | Chief Executive Officer | Feb 25, 2021 | Option Exercise | $7.10 | 33,979 | 241,251 | 240,015 | Feb 26, 2021, 04:03 PM |
| MARAGANORE JOHN | Chief Executive Officer | Feb 25, 2021 | Sale | $147.31 | 33,979 | 5,005,421 | 239,014 | Feb 26, 2021, 04:03 PM |
| Vaishnaw Akshay | President, R&D | Feb 12, 2021 | Option Exercise | $155.81 | 1,710 | 266,441 | 17,917 | Feb 16, 2021, 04:09 PM |
| Greenstreet Yvonne | President & COO | Feb 12, 2021 | Option Exercise | $155.99 | 1,945 | 303,403 | 8,395 | Feb 16, 2021, 04:07 PM |
| KEATING LAURIE | EVP, Chief Legal Officer | Feb 12, 2021 | Option Exercise | $155.87 | 1,963 | 305,967 | 4,543 | Feb 16, 2021, 12:00 AM |
| MARAGANORE JOHN | Chief Executive Officer | Feb 12, 2021 | Option Exercise | $155.78 | 5,719 | 890,917 | 206,343 | Feb 16, 2021, 12:00 AM |
| KEATING LAURIE | EVP, Chief Legal Officer | Jan 13, 2021 | Option Exercise | $82.45 | 9,027 | 744,290 | 11,261 | Jan 15, 2021, 04:03 PM |
| KEATING LAURIE | EVP, Chief Legal Officer | Jan 13, 2021 | Sale | $169.90 | 9,027 | 1,533,698 | 6,261 | Jan 15, 2021, 04:03 PM |
| KEATING LAURIE | EVP, Chief Legal Officer | Jan 12, 2021 | Option Exercise | $72.83 | 14,941 | 1,088,149 | 17,175 | Jan 13, 2021, 04:05 PM |
| KEATING LAURIE | EVP, Chief Legal Officer | Jan 12, 2021 | Sale | $160.20 | 14,941 | 2,393,619 | 5,234 | Jan 13, 2021, 04:05 PM |
| KEATING LAURIE | EVP, Chief Legal Officer | Jan 11, 2021 | Sale | $154.00 | 758 | 116,732 | 2,234 | Jan 13, 2021, 04:05 PM |
| Greenstreet Yvonne | President & COO | Jan 12, 2021 | Option Exercise | $42.22 | 3,125 | 131,938 | 7,945 | Jan 13, 2021, 04:04 PM |
| Greenstreet Yvonne | President & COO | Jan 12, 2021 | Sale | $161.00 | 3,125 | 503,125 | 4,820 | Jan 13, 2021, 04:04 PM |
| PAUL STEVEN M | Director | Dec 18, 2020 | Option Exercise | $9.30 | 15,000 | 139,500 | 16,000 | Dec 22, 2020, 04:02 PM |
| PAUL STEVEN M | Director | Dec 18, 2020 | Sale | $140.00 | 15,000 | 2,100,000 | 1,000 | Dec 22, 2020, 04:02 PM |
| SHARP PHILLIP A | Director | Nov 25, 2020 | Option Exercise | $9.30 | 30,000 | 279,000 | 265,633 | Nov 30, 2020, 04:03 PM |
| SHARP PHILLIP A | Director | Nov 25, 2020 | Sale | $124.89 | 30,000 | 3,746,749 | 254,110 | Nov 30, 2020, 04:03 PM |
| MARAGANORE JOHN | Chief Executive Officer | Nov 19, 2020 | Option Exercise | $9.14 | 34,765 | 317,752 | 232,354 | Nov 20, 2020, 04:02 PM |
| MARAGANORE JOHN | Chief Executive Officer | Nov 19, 2020 | Sale | $124.23 | 34,765 | 4,319,025 | 213,367 | Nov 20, 2020, 04:02 PM |
| Vaishnaw Akshay | President, R&D | Sep 29, 2020 | Option Exercise | $42.22 | 971 | 40,996 | 15,090 | Oct 01, 2020, 04:03 PM |
| Vaishnaw Akshay | President, R&D | Sep 29, 2020 | Sale | $140.00 | 971 | 135,940 | 14,119 | Oct 01, 2020, 04:03 PM |
| Greene Barry E | President | Sep 09, 2020 | Option Exercise | $9.14 | 44,530 | 407,004 | 114,873 | Sep 11, 2020, 05:11 PM |
| Greene Barry E | President | Sep 09, 2020 | Sale | $123.23 | 44,530 | 5,487,595 | 100,798 | Sep 11, 2020, 05:11 PM |
| MARAGANORE JOHN | Chief Executive Officer | Aug 20, 2020 | Option Exercise | $9.14 | 34,765 | 317,752 | 232,354 | Aug 21, 2020, 04:06 PM |
| MARAGANORE JOHN | Chief Executive Officer | Aug 20, 2020 | Sale | $136.13 | 34,765 | 4,732,542 | 227,579 | Aug 21, 2020, 04:06 PM |
| Greene Barry E | President | Aug 10, 2020 | Option Exercise | $70.95 | 4,931 | 349,871 | 67,167 | Aug 11, 2020, 04:09 PM |
| KEATING LAURIE | EVP, Chief Legal Officer | Jul 13, 2020 | Option Exercise | $87.16 | 35,750 | 3,116,066 | 50,242 | Jul 14, 2020, 04:03 PM |
| KEATING LAURIE | EVP, Chief Legal Officer | Jul 13, 2020 | Sale | $160.67 | 47,250 | 7,591,791 | 45,760 | Jul 14, 2020, 04:03 PM |
| Greenstreet Yvonne | Chief Operating Officer | Jul 10, 2020 | Option Exercise | $77.10 | 46,639 | 3,595,867 | 51,459 | Jul 14, 2020, 04:02 PM |
| Greenstreet Yvonne | Chief Operating Officer | Jul 10, 2020 | Sale | $161.00 | 46,639 | 7,508,879 | 4,820 | Jul 14, 2020, 04:02 PM |
| Greenstreet Yvonne | Chief Operating Officer | Jul 09, 2020 | Option Exercise | $43.14 | 11,236 | 484,743 | 16,056 | Jul 10, 2020, 04:03 PM |
| Greenstreet Yvonne | Chief Operating Officer | Jul 09, 2020 | Sale | $161.00 | 11,236 | 1,808,996 | 4,820 | Jul 10, 2020, 04:03 PM |
| Greene Barry E | President | Jul 07, 2020 | Option Exercise | $9.14 | 22,265 | 203,502 | 84,501 | Jul 09, 2020, 04:02 PM |
| Greene Barry E | President | Jul 07, 2020 | Sale | $159.99 | 22,265 | 3,562,177 | 62,236 | Jul 09, 2020, 04:02 PM |
| Vaishnaw Akshay | President, R&D | Jun 22, 2020 | Option Exercise | $42.22 | 970 | 40,953 | 15,089 | Jun 24, 2020, 04:02 PM |
| Vaishnaw Akshay | President, R&D | Jun 22, 2020 | Sale | $151.07 | 970 | 146,536 | 14,911 | Jun 24, 2020, 04:02 PM |
| MARAGANORE JOHN | Chief Executive Officer | May 20, 2020 | Option Exercise | $9.14 | 34,765 | 317,752 | 232,354 | May 22, 2020, 04:03 PM |
| MARAGANORE JOHN | Chief Executive Officer | May 20, 2020 | Sale | $143.22 | 34,765 | 4,978,983 | 218,917 | May 22, 2020, 04:03 PM |
| Greene Barry E | President | May 06, 2020 | Option Exercise | $9.14 | 22,265 | 203,502 | 84,501 | May 07, 2020, 04:09 PM |
| Greene Barry E | President | May 06, 2020 | Sale | $149.99 | 22,265 | 3,339,527 | 62,236 | May 07, 2020, 04:09 PM |
| Greenstreet Yvonne | Chief Operating Officer | May 06, 2020 | Option Exercise | $77.10 | 50,000 | 3,855,000 | 54,820 | May 07, 2020, 04:08 PM |
| Greenstreet Yvonne | Chief Operating Officer | May 05, 2020 | Option Exercise | $42.22 | 7,811 | 329,780 | 12,631 | May 07, 2020, 04:08 PM |
| Greenstreet Yvonne | Chief Operating Officer | May 06, 2020 | Sale | $150.00 | 50,000 | 7,500,000 | 4,820 | May 07, 2020, 04:08 PM |
| Greenstreet Yvonne | Chief Operating Officer | May 05, 2020 | Sale | $140.00 | 7,811 | 1,093,540 | 4,820 | May 07, 2020, 04:08 PM |
| KEATING LAURIE | EVP, Chief Legal Officer | Apr 20, 2020 | Option Exercise | $77.40 | 10,000 | 774,000 | 24,492 | Apr 22, 2020, 04:07 PM |
| KEATING LAURIE | EVP, Chief Legal Officer | Apr 20, 2020 | Sale | $139.00 | 10,000 | 1,390,000 | 14,492 | Apr 22, 2020, 04:07 PM |
| Vaishnaw Akshay | President, R&D | Apr 20, 2020 | Option Exercise | $42.22 | 21,971 | 927,616 | 36,090 | Apr 22, 2020, 04:06 PM |
| Vaishnaw Akshay | President, R&D | Apr 20, 2020 | Sale | $140.00 | 21,971 | 3,075,940 | 14,119 | Apr 22, 2020, 04:06 PM |
| Greene Barry E | President | Apr 07, 2020 | Option Exercise | $104.82 | 1,663 | 174,321 | 62,300 | Apr 09, 2020, 04:06 PM |
| Greenstreet Yvonne | Chief Operating Officer | Apr 07, 2020 | Option Exercise | $104.86 | 2,513 | 263,503 | 4,918 | Apr 09, 2020, 04:05 PM |
| KEATING LAURIE | EVP, Chief Legal Officer | Apr 07, 2020 | Option Exercise | $104.78 | 1,933 | 202,548 | 14,567 | Apr 09, 2020, 04:04 PM |
| MARAGANORE JOHN | Chief Executive Officer | Apr 07, 2020 | Option Exercise | $104.81 | 6,571 | 688,701 | 197,845 | Apr 09, 2020, 04:04 PM |
| Vaishnaw Akshay | President, R&D | Apr 07, 2020 | Option Exercise | $104.82 | 2,513 | 263,410 | 14,217 | Apr 09, 2020, 04:03 PM |
| MARAGANORE JOHN | Chief Executive Officer | Feb 20, 2020 | Option Exercise | $9.14 | 34,765 | 317,752 | 224,758 | Feb 21, 2020, 04:02 PM |
| MARAGANORE JOHN | Chief Executive Officer | Feb 20, 2020 | Sale | $131.85 | 34,765 | 4,583,674 | 222,086 | Feb 21, 2020, 04:02 PM |
| SHARP PHILLIP A | Director | Feb 12, 2020 | Option Exercise | $12.48 | 30,000 | 374,400 | 265,633 | Feb 13, 2020, 04:06 PM |
| SHARP PHILLIP A | Director | Feb 12, 2020 | Sale | $130.00 | 30,000 | 3,900,000 | 235,633 | Feb 13, 2020, 04:06 PM |
| KEATING LAURIE | EVP, Chief Legal Officer | Feb 10, 2020 | Option Exercise | $77.40 | 10,000 | 774,000 | 22,258 | Feb 12, 2020, 04:03 PM |
| KEATING LAURIE | EVP, Chief Legal Officer | Feb 10, 2020 | Sale | $129.00 | 10,000 | 1,290,000 | 12,258 | Feb 12, 2020, 04:03 PM |
| KEATING LAURIE | EVP, Chief Legal Officer | Jan 27, 2020 | Option Exercise | $77.40 | 3,663 | 283,516 | 12,258 | Feb 12, 2020, 04:02 PM |
| PAUL STEVEN M | Director | Feb 10, 2020 | Option Exercise | $14.67 | 30,000 | 440,100 | 31,000 | Feb 11, 2020, 04:08 PM |
| PAUL STEVEN M | Director | Feb 10, 2020 | Sale | $130.00 | 30,000 | 3,900,000 | 1,000 | Feb 11, 2020, 04:08 PM |
| Vaishnaw Akshay | President, R&D | Feb 07, 2020 | Option Exercise | $42.22 | 22,750 | 960,505 | 34,923 | Feb 11, 2020, 04:08 PM |
| Vaishnaw Akshay | President, R&D | Feb 07, 2020 | Sale | $125.00 | 23,708 | 2,963,500 | 11,215 | Feb 11, 2020, 04:08 PM |
| Greenstreet Yvonne | Chief Operating Officer | Feb 07, 2020 | Option Exercise | $42.22 | 6,250 | 263,875 | 12,458 | Feb 11, 2020, 04:08 PM |
| Greenstreet Yvonne | Chief Operating Officer | Feb 10, 2020 | Option Exercise | $42.22 | 5,600 | 236,432 | 11,808 | Feb 11, 2020, 04:08 PM |
| Greenstreet Yvonne | Chief Operating Officer | Feb 07, 2020 | Sale | $123.90 | 6,250 | 774,375 | 6,208 | Feb 11, 2020, 04:08 PM |
| Greenstreet Yvonne | Chief Operating Officer | Feb 10, 2020 | Sale | $130.00 | 9,892 | 1,285,960 | 1,916 | Feb 11, 2020, 04:08 PM |
| KEATING LAURIE | EVP, Chief Legal Officer | Jan 29, 2020 | Option Exercise | $77.40 | 6,337 | 490,484 | 14,932 | Jan 31, 2020, 04:05 PM |
| KEATING LAURIE | EVP, Chief Legal Officer | Jan 29, 2020 | Sale | $119.00 | 6,337 | 754,103 | 8,595 | Jan 31, 2020, 04:05 PM |
| KEATING LAURIE | EVP, Chief Legal Officer | Jan 27, 2020 | Option Exercise | $42.22 | 34,374 | 1,451,270 | 49,632 | Jan 29, 2020, 04:03 PM |
| KEATING LAURIE | EVP, Chief Legal Officer | Jan 27, 2020 | Sale | $117.70 | 41,037 | 4,829,970 | 46,267 | Jan 29, 2020, 04:03 PM |
| Greenstreet Yvonne | Chief Operating Officer | Dec 12, 2019 | Option Exercise | $120.61 | 3,208 | 386,917 | 6,208 | Dec 13, 2019, 04:25 PM |
| Fanucci Marsha | Director | Nov 20, 2019 | Option Exercise | $13.80 | 75,000 | 1,035,000 | 75,000 | Nov 22, 2019, 04:06 PM |
| Fanucci Marsha | Director | Nov 20, 2019 | Sale | $100.00 | 75,000 | 7,500,000 | 0 | Nov 22, 2019, 04:06 PM |
| Greenstreet Yvonne | Chief Operating Officer | Nov 20, 2019 | Option Exercise | $42.22 | 8,404 | 354,817 | 10,320 | Nov 22, 2019, 04:05 PM |
| Greenstreet Yvonne | Chief Operating Officer | Nov 20, 2019 | Sale | $105.00 | 8,404 | 882,420 | 1,916 | Nov 22, 2019, 04:05 PM |
| SHARP PHILLIP A | Director | Nov 18, 2019 | Option Exercise | $16.43 | 15,000 | 246,450 | 250,633 | Nov 20, 2019, 04:17 PM |
| SHARP PHILLIP A | Director | Nov 18, 2019 | Sale | $91.71 | 15,000 | 1,375,662 | 245,074 | Nov 20, 2019, 04:17 PM |
| Greene Barry E | President | Oct 22, 2019 | Option Exercise | $16.43 | 58,913 | 967,941 | 111,851 | Oct 24, 2019, 04:04 PM |
| Greene Barry E | President | Oct 22, 2019 | Sale | $89.99 | 58,913 | 5,301,581 | 52,938 | Oct 24, 2019, 04:04 PM |
| MARAGANORE JOHN | Chief Executive Officer | Oct 14, 2019 | Option Exercise | $16.43 | 49,456 | 812,562 | 239,449 | Oct 16, 2019, 04:06 PM |
| MARAGANORE JOHN | Chief Executive Officer | Oct 14, 2019 | Sale | $79.45 | 49,456 | 3,929,210 | 218,617 | Oct 16, 2019, 04:06 PM |
| MARAGANORE JOHN | Chief Executive Officer | May 15, 2019 | Option Exercise | $16.43 | 49,457 | 812,579 | 239,450 | May 17, 2019, 04:07 PM |
| MARAGANORE JOHN | Chief Executive Officer | May 15, 2019 | Sale | $70.00 | 49,457 | 3,461,990 | 189,993 | May 17, 2019, 04:07 PM |
| SHARP PHILIP A | Director | Apr 15, 2019 | Option Exercise | $22.09 | 15,000 | 331,350 | 250,633 | Apr 17, 2019, 04:05 PM |
| SHARP PHILIP A | Director | Apr 15, 2019 | Sale | $88.23 | 15,000 | 1,323,442 | 238,833 | Apr 17, 2019, 04:05 PM |
| MARAGANORE JOHN | Chief Executive Officer | Nov 21, 2018 | Option Exercise | $72.68 | 59,940 | 4,356,439 | 189,993 | Nov 26, 2018, 04:11 PM |
| MARAGANORE JOHN | Chief Executive Officer | Nov 21, 2018 | Option Exercise | $21.35 | 98,636 | 2,105,879 | 249,933 | Nov 26, 2018, 04:11 PM |
| Greenstreet Yvonne | EVP, Chief Operating Officer | Aug 30, 2018 | Sale | $120.00 | 2,500 | 300,000 | 1,916 | Sep 04, 2018, 04:15 PM |
| Vaishnaw Akshay | President, R&D | Aug 13, 2018 | Option Exercise | $90.95 | 766 | 69,668 | 12,173 | Aug 14, 2018, 06:55 PM |
| Greenstreet Yvonne | EVP, Chief Operating Officer | Aug 13, 2018 | Option Exercise | $90.95 | 3,084 | 280,490 | 4,416 | Aug 14, 2018, 06:21 PM |
| KEATING LAURIE | SVP, GC & Secretary | Aug 13, 2018 | Option Exercise | $90.95 | 605 | 55,025 | 15,258 | Aug 14, 2018, 06:05 PM |
| Mason Michael | VP, Finance and Treasurer | Aug 13, 2018 | Option Exercise | $90.95 | 449 | 40,837 | 563 | Aug 14, 2018, 06:00 PM |
| MARAGANORE JOHN | Chief Executive Officer | Jul 25, 2018 | Option Exercise | $21.35 | 50,000 | 1,067,500 | 201,297 | Jul 27, 2018, 04:07 PM |
| MARAGANORE JOHN | Chief Executive Officer | Jul 25, 2018 | Sale | $105.39 | 50,000 | 5,269,458 | 199,297 | Jul 27, 2018, 04:07 PM |
| KEATING LAURIE | SVP, GC & Secretary | Jun 20, 2018 | Option Exercise | $42.22 | 1,563 | 65,990 | 16,063 | Jun 22, 2018, 04:20 PM |
| KEATING LAURIE | SVP, GC & Secretary | Jun 20, 2018 | Sale | $105.04 | 1,563 | 164,178 | 14,500 | Jun 22, 2018, 04:20 PM |
| CLARKE JOHN K | Director | May 31, 2018 | Option Exercise | $27.28 | 15,000 | 409,200 | 23,891 | Jun 04, 2018, 04:25 PM |
| CLARKE JOHN K | Director | May 31, 2018 | Sale | $100.31 | 15,000 | 1,504,678 | 21,133 | Jun 04, 2018, 04:25 PM |
| Greenstreet Yvonne | EVP, Chief Operating Officer | Mar 26, 2018 | Option Exercise | $42.22 | 7,221 | 304,871 | 7,221 | Mar 28, 2018, 04:39 PM |
| Greenstreet Yvonne | EVP, Chief Operating Officer | Mar 26, 2018 | Sale | $136.54 | 7,221 | 985,958 | 2,913 | Mar 28, 2018, 04:39 PM |
| KEATING LAURIE | SVP, GC & Secretary | Mar 20, 2018 | Option Exercise | $42.22 | 1,562 | 65,948 | 16,062 | Mar 22, 2018, 06:18 PM |
| KEATING LAURIE | SVP, GC & Secretary | Mar 20, 2018 | Sale | $149.83 | 1,562 | 234,033 | 15,962 | Mar 22, 2018, 06:18 PM |
| Vaishnaw Akshay | President, R&D | Mar 14, 2018 | Option Exercise | $17.03 | 88,554 | 1,507,842 | 99,769 | Mar 16, 2018, 05:05 PM |
| Vaishnaw Akshay | President, R&D | Mar 14, 2018 | Sale | $143.10 | 88,554 | 12,672,126 | 93,316 | Mar 16, 2018, 05:05 PM |
| Greene Barry E | President | Mar 14, 2018 | Sale | $143.10 | 38,460 | 5,503,736 | 97,544 | Mar 16, 2018, 05:05 PM |
| KEATING LAURIE | SVP, GC & Secretary | Mar 13, 2018 | Option Exercise | $77.40 | 10,000 | 774,000 | 24,500 | Mar 14, 2018, 07:40 PM |
| KEATING LAURIE | SVP, GC & Secretary | Mar 12, 2018 | Option Exercise | $77.40 | 10,000 | 774,000 | 24,500 | Mar 14, 2018, 07:40 PM |
| KEATING LAURIE | SVP, GC & Secretary | Mar 12, 2018 | Sale | $140.00 | 10,000 | 1,400,000 | 14,500 | Mar 14, 2018, 07:40 PM |
| KEATING LAURIE | SVP, GC & Secretary | Mar 13, 2018 | Sale | $150.00 | 10,000 | 1,500,000 | 14,500 | Mar 14, 2018, 07:40 PM |
| Ausiello Dennis A | Director | Mar 13, 2018 | Option Exercise | $59.82 | 17,117 | 1,023,942 | 17,117 | Mar 14, 2018, 07:40 PM |
| Ausiello Dennis A | Director | Mar 13, 2018 | Sale | $150.00 | 17,117 | 2,567,550 | 0 | Mar 14, 2018, 07:40 PM |
| SHARP PHILIP A | Director | Mar 13, 2018 | Option Exercise | $21.35 | 15,000 | 320,250 | 155,795 | Mar 14, 2018, 07:39 PM |
| SHARP PHILIP A | Director | Mar 13, 2018 | Sale | $149.00 | 15,000 | 2,235,000 | 140,795 | Mar 14, 2018, 07:39 PM |
| SCHIMMEL PAUL | Director | Mar 13, 2018 | Option Exercise | $49.24 | 27,823 | 1,369,927 | 27,823 | Mar 14, 2018, 07:39 PM |
| SCHIMMEL PAUL | Director | Mar 13, 2018 | Sale | $150.00 | 27,823 | 4,173,450 | 0 | Mar 14, 2018, 07:39 PM |
| SHARP PHILIP A | Director | Mar 09, 2018 | Option Exercise | $27.28 | 15,000 | 409,200 | 155,795 | Mar 13, 2018, 05:22 PM |
| SHARP PHILIP A | Director | Mar 09, 2018 | Sale | $129.00 | 15,000 | 1,935,000 | 140,795 | Mar 13, 2018, 05:22 PM |
| Mason Michael | VP, Finance and Treasurer | Jan 04, 2018 | Option Exercise | $88.26 | 31,781 | 2,804,910 | 36,745 | Jan 08, 2018, 05:02 PM |
| Mason Michael | VP, Finance and Treasurer | Jan 04, 2018 | Sale | $131.59 | 36,745 | 4,835,171 | 31,496 | Jan 08, 2018, 05:02 PM |
| Mason Michael | VP, Finance and Treasurer | Dec 30, 2017 | Option Exercise | $127.05 | 3,538 | 449,503 | 4,964 | Jan 03, 2018, 05:26 PM |
| KEATING LAURIE | SVP, GC & Secretary | Dec 29, 2017 | Option Exercise | $77.40 | 3,000 | 232,200 | 14,500 | Jan 03, 2018, 05:13 PM |
| KEATING LAURIE | SVP, GC & Secretary | Dec 20, 2017 | Option Exercise | $42.22 | 6,249 | 263,833 | 17,749 | Dec 21, 2017, 05:00 PM |
| KEATING LAURIE | SVP, GC & Secretary | Dec 20, 2017 | Sale | $121.20 | 6,249 | 757,398 | 13,700 | Dec 21, 2017, 05:00 PM |
| MARAGANORE JOHN | Chief Executive Officer | Dec 19, 2017 | Option Exercise | $63.00 | 1,587 | 99,981 | 151,297 | Dec 21, 2017, 04:36 PM |
| KEATING LAURIE | SVP, GC and Secretary | Dec 01, 2017 | Option Exercise | $77.40 | 30,000 | 2,322,000 | 41,500 | Dec 05, 2017, 05:47 PM |
| KEATING LAURIE | SVP, GC and Secretary | Dec 01, 2017 | Sale | $135.89 | 30,000 | 4,076,823 | 38,700 | Dec 05, 2017, 05:47 PM |
| MARAGANORE JOHN | Chief Executive Officer | Nov 22, 2017 | Option Exercise | $31.39 | 73,415 | 2,304,497 | 223,125 | Nov 24, 2017, 06:55 PM |
| MARAGANORE JOHN | Chief Executive Officer | Nov 22, 2017 | Sale | $130.90 | 73,415 | 9,609,737 | 197,862 | Nov 24, 2017, 06:55 PM |
| MARAGANORE JOHN | Chief Executive Officer | Nov 15, 2017 | Option Exercise | $31.39 | 74,000 | 2,322,860 | 223,710 | Nov 17, 2017, 05:35 PM |
| MARAGANORE JOHN | Chief Executive Officer | Nov 15, 2017 | Sale | $126.86 | 74,000 | 9,387,951 | 201,250 | Nov 17, 2017, 05:35 PM |
| Ausiello Dennis A | Director | Nov 02, 2017 | Option Exercise | $30.09 | 20,000 | 601,800 | 20,000 | Nov 03, 2017, 08:14 PM |
| Ausiello Dennis A | Director | Nov 02, 2017 | Sale | $130.00 | 20,000 | 2,600,000 | 0 | Nov 03, 2017, 08:14 PM |
| Vaishnaw Akshay | EVP, R&D | Oct 30, 2017 | Option Exercise | $21.35 | 33,666 | 718,769 | 45,201 | Nov 01, 2017, 05:33 PM |
| Vaishnaw Akshay | EVP, R&D | Oct 30, 2017 | Sale | $121.46 | 33,666 | 4,088,967 | 44,401 | Nov 01, 2017, 05:33 PM |
| Greene Barry E | President | Oct 02, 2017 | Option Exercise | $21.35 | 85,316 | 1,821,497 | 185,744 | Oct 04, 2017, 07:45 PM |
| Greene Barry E | President | Oct 02, 2017 | Sale | $125.00 | 85,316 | 10,664,500 | 100,428 | Oct 04, 2017, 07:45 PM |
| Greene Barry E | President | Sep 21, 2017 | Option Exercise | $12.33 | 11,844 | 146,042 | 100,428 | Sep 22, 2017, 05:05 PM |
| Greene Barry E | President | Sep 20, 2017 | Option Exercise | $31.39 | 76,815 | 2,411,223 | 165,399 | Sep 22, 2017, 05:05 PM |
| Greene Barry E | President | Sep 20, 2017 | Sale | $100.00 | 76,815 | 7,681,500 | 88,584 | Sep 22, 2017, 05:05 PM |
| Vaishnaw Akshay | EVP, R&D | Jun 13, 2017 | Option Exercise | $74.31 | 430 | 31,953 | 11,535 | Jun 15, 2017, 05:45 PM |
| Vaishnaw Akshay | EVP, R&D | Jun 13, 2017 | Option Exercise | $19.19 | 1,668 | 32,007 | 11,965 | Jun 15, 2017, 05:45 PM |
| Sanofi | 10% Owner | May 31, 2017 | Buy | $71.87 | 297,501 | 21,381,398 | 10,554,134 | Jun 01, 2017, 07:41 PM |
| KEATING LAURIE | SVP, GC and Secretary | May 30, 2017 | Buy | $65.35 | 11,500 | 751,502 | 11,500 | May 31, 2017, 05:22 PM |
| Vaishnaw Akshay | EVP, R&D | May 23, 2017 | Option Exercise | $21.35 | 11,000 | 234,850 | 21,297 | May 25, 2017, 06:39 PM |
| Vaishnaw Akshay | EVP, R&D | May 23, 2017 | Sale | $75.00 | 11,000 | 825,000 | 10,297 | May 25, 2017, 06:39 PM |
| Mason Michael | VP, Finance and Treasurer | May 16, 2017 | Option Exercise | $14.04 | 9,375 | 131,587 | 9,375 | May 17, 2017, 06:45 PM |
| Mason Michael | VP, Finance and Treasurer | May 16, 2017 | Sale | $70.00 | 9,375 | 656,250 | 0 | May 17, 2017, 06:45 PM |
| Vaishnaw Akshay | SVP, R&D | May 15, 2017 | Option Exercise | $28.87 | 43,750 | 1,262,872 | 43,047 | May 17, 2017, 06:31 PM |
| Vaishnaw Akshay | SVP, R&D | May 15, 2017 | Sale | $65.00 | 43,750 | 2,843,750 | 10,297 | May 17, 2017, 06:31 PM |
| SHARP PHILIP A | Director | Feb 01, 2017 | Option Exercise | $31.29 | 25,000 | 782,250 | 165,795 | Feb 03, 2017, 04:32 PM |
| SHARP PHILIP A | Director | Feb 01, 2017 | Sale | $39.80 | 25,000 | 995,125 | 145,624 | Feb 03, 2017, 04:32 PM |
| SHARP PHILIP A | Director | Jan 25, 2017 | Option Exercise | $31.39 | 15,000 | 470,850 | 155,795 | Jan 27, 2017, 04:10 PM |
| SHARP PHILIP A | Director | Jan 25, 2017 | Sale | $37.95 | 15,000 | 569,250 | 140,795 | Jan 27, 2017, 04:10 PM |
| SHARP PHILIP A | Director | Jan 18, 2017 | Option Exercise | $15.91 | 15,000 | 238,650 | 155,795 | Jan 20, 2017, 04:12 PM |
| SHARP PHILIP A | Director | Jan 18, 2017 | Sale | $37.83 | 15,000 | 567,456 | 146,995 | Jan 20, 2017, 04:12 PM |
| MARAGANORE JOHN | Chief Executive Officer | Jan 05, 2017 | Option Exercise | $18.66 | 1,340 | 25,004 | 149,710 | Jan 06, 2017, 04:22 PM |
| Vaishnaw Akshay | EVP, R&D | Dec 30, 2016 | Option Exercise | $37.44 | 5,000 | 187,200 | 10,297 | Jan 04, 2017, 05:30 PM |
| Vaishnaw Akshay | EVP, R&D | Dec 30, 2016 | Option Exercise | $19.61 | 9,547 | 187,251 | 15,297 | Jan 04, 2017, 05:30 PM |
| MARAGANORE JOHN | Chief Executive Officer | Dec 12, 2016 | Option Exercise | $42.61 | 22,710 | 967,673 | 148,370 | Dec 14, 2016, 04:18 PM |
| MARAGANORE JOHN | Chief Executive Officer | Dec 12, 2016 | Option Exercise | $22.75 | 30,151 | 685,935 | 171,080 | Dec 14, 2016, 04:18 PM |
| Greene Barry E | President | Dec 01, 2016 | Option Exercise | $22.75 | 55,605 | 1,265,014 | 120,409 | Dec 05, 2016, 04:55 PM |
| Greene Barry E | President | Dec 01, 2016 | Sale | $42.99 | 31,825 | 1,368,128 | 106,060 | Dec 05, 2016, 04:55 PM |
| Vaishnaw Akshay | EVP, R&D, CMO | Nov 30, 2016 | Option Exercise | $22.75 | 29,165 | 663,504 | 34,915 | Dec 02, 2016, 04:59 PM |
| Vaishnaw Akshay | EVP, R&D, CMO | Nov 30, 2016 | Sale | $44.99 | 29,165 | 1,311,998 | 20,547 | Dec 02, 2016, 04:59 PM |
| PYOTT DAVID E I | Director | Oct 13, 2016 | Buy | $37.00 | 27,900 | 1,032,328 | 27,900 | Oct 14, 2016, 04:22 PM |
| MARAGANORE JOHN | Chief Executive Officer | Oct 12, 2016 | Option Exercise | $13.26 | 7,540 | 99,994 | 140,929 | Oct 14, 2016, 04:17 PM |
| MARAGANORE JOHN | CEO | Jul 20, 2016 | Option Exercise | $22.75 | 15,075 | 342,956 | 148,464 | Jul 21, 2016, 05:44 PM |
| MARAGANORE JOHN | CEO | Jul 19, 2016 | Option Exercise | $22.75 | 15,076 | 342,979 | 148,465 | Jul 21, 2016, 05:44 PM |
| MARAGANORE JOHN | CEO | Jul 20, 2016 | Sale | $65.58 | 15,075 | 988,592 | 147,864 | Jul 21, 2016, 05:44 PM |
| MARAGANORE JOHN | CEO | Jul 19, 2016 | Sale | $63.81 | 15,076 | 961,998 | 134,894 | Jul 21, 2016, 05:44 PM |
| MARAGANORE JOHN | Chief Executive Officer | Apr 20, 2016 | Option Exercise | $22.75 | 15,075 | 342,956 | 148,464 | Apr 21, 2016, 05:01 PM |
| MARAGANORE JOHN | Chief Executive Officer | Apr 19, 2016 | Option Exercise | $22.75 | 15,076 | 342,979 | 148,465 | Apr 21, 2016, 05:01 PM |
| MARAGANORE JOHN | Chief Executive Officer | Apr 19, 2016 | Sale | $67.41 | 15,076 | 1,016,199 | 139,094 | Apr 21, 2016, 05:01 PM |
| MARAGANORE JOHN | Chief Executive Officer | Apr 20, 2016 | Sale | $67.51 | 15,075 | 1,017,773 | 135,794 | Apr 21, 2016, 05:01 PM |
| Greene Barry E | President and COO | Mar 24, 2016 | Option Exercise | $8.20 | 16,540 | 135,672 | 64,804 | Mar 28, 2016, 05:27 PM |
| BONNEY MICHAEL W | Director | Mar 09, 2016 | Buy | $58.36 | 2,000 | 116,720 | 4,000 | Mar 10, 2016, 06:35 PM |
| Gros David-Alexandre C | SVP, Chief Business Officer | Feb 22, 2016 | Buy | $62.75 | 1,000 | 62,749 | 1,000 | Feb 24, 2016, 06:21 PM |
| Sanofi | 10% Owner | Feb 01, 2016 | Buy | $69.75 | 205,030 | 14,300,843 | 10,256,633 | Feb 03, 2016, 07:00 AM |
| MARAGANORE JOHN | Chief Executive Officer | Jan 20, 2016 | Option Exercise | $22.75 | 15,076 | 342,979 | 148,465 | Jan 21, 2016, 06:59 PM |
| MARAGANORE JOHN | Chief Executive Officer | Jan 19, 2016 | Option Exercise | $22.75 | 15,076 | 342,979 | 148,465 | Jan 21, 2016, 06:59 PM |
| MARAGANORE JOHN | Chief Executive Officer | Jan 20, 2016 | Sale | $69.46 | 15,076 | 1,047,234 | 147,265 | Jan 21, 2016, 06:59 PM |
| MARAGANORE JOHN | Chief Executive Officer | Jan 19, 2016 | Sale | $74.09 | 15,076 | 1,116,985 | 146,627 | Jan 21, 2016, 06:59 PM |
| SHARP PHILIP A | Director | Dec 04, 2015 | Option Exercise | $14.28 | 30,000 | 428,400 | 170,795 | Dec 04, 2015, 06:11 PM |
| SHARP PHILIP A | Director | Dec 04, 2015 | Sale | $109.00 | 30,000 | 3,270,000 | 140,795 | Dec 04, 2015, 06:11 PM |
| MARAGANORE JOHN | Chief Executive Officer | Dec 02, 2015 | Option Exercise | $13.12 | 58,689 | 770,000 | 192,078 | Dec 04, 2015, 05:10 PM |
| MARAGANORE JOHN | Chief Executive Officer | Dec 02, 2015 | Sale | $104.87 | 58,689 | 6,154,716 | 182,095 | Dec 04, 2015, 05:10 PM |
| Vaishnaw Akshay | EVP, R&D, CMO | Nov 25, 2015 | Option Exercise | $17.35 | 5,750 | 99,750 | 5,750 | Nov 30, 2015, 05:45 PM |
| MARAGANORE JOHN | Chief Executive Officer | Nov 20, 2015 | Option Exercise | $12.20 | 69,254 | 845,017 | 192,079 | Nov 20, 2015, 06:12 PM |
| MARAGANORE JOHN | Chief Executive Officer | Nov 20, 2015 | Sale | $102.88 | 58,690 | 6,037,939 | 164,942 | Nov 20, 2015, 06:12 PM |
| STARR KEVIN P | Director | Nov 11, 2015 | Option Exercise | $9.98 | 37,500 | 374,125 | 37,500 | Nov 13, 2015, 04:36 PM |
| STARR KEVIN P | Director | Nov 12, 2015 | Option Exercise | $14.32 | 37,500 | 537,125 | 37,500 | Nov 13, 2015, 04:36 PM |
| STARR KEVIN P | Director | Nov 11, 2015 | Sale | $107.65 | 37,500 | 4,037,036 | 35,226 | Nov 13, 2015, 04:36 PM |
| STARR KEVIN P | Director | Nov 12, 2015 | Sale | $100.14 | 37,500 | 3,755,067 | 2,100 | Nov 13, 2015, 04:36 PM |
| Greene Barry E | President and COO | Aug 04, 2015 | Option Exercise | $18.73 | 26,972 | 505,124 | 50,364 | Aug 06, 2015, 05:32 PM |
| Vaishnaw Akshay | EVP, R&D, CMO | Jun 16, 2015 | Option Exercise | $8.67 | 8,750 | 75,875 | 8,750 | Jun 18, 2015, 04:38 PM |
| Vaishnaw Akshay | EVP, R&D, CMO | Jun 16, 2015 | Sale | $128.83 | 8,750 | 1,127,236 | 4,817 | Jun 18, 2015, 04:38 PM |
| Mason Michael | VP, Finance and Treasurer | Jun 01, 2015 | Option Exercise | $46.03 | 4,791 | 220,526 | 4,791 | Jun 03, 2015, 04:33 PM |
| Mason Michael | VP, Finance and Treasurer | Jun 01, 2015 | Sale | $131.84 | 4,791 | 631,647 | 4,031 | Jun 03, 2015, 04:33 PM |
| Greene Barry E | President and COO | May 26, 2015 | Option Exercise | $13.12 | 67,379 | 884,012 | 90,771 | May 28, 2015, 04:16 PM |
| Greene Barry E | President and COO | May 26, 2015 | Sale | $125.00 | 67,379 | 8,422,375 | 23,392 | May 28, 2015, 04:16 PM |
| BONNEY MICHAEL W | Director | May 12, 2015 | Buy | $112.16 | 2,000 | 224,320 | 2,000 | May 13, 2015, 06:00 PM |
| Ausiello Dennis A | Director | Apr 21, 2015 | Sale | $130.02 | 8,165 | 1,061,613 | 0 | Apr 23, 2015, 04:43 PM |
| SCHIMMEL PAUL | Director | Apr 21, 2015 | Option Exercise | $28.69 | 10,000 | 286,850 | 10,000 | Apr 23, 2015, 04:43 PM |
| SCHIMMEL PAUL | Director | Apr 21, 2015 | Sale | $130.02 | 10,000 | 1,300,200 | 0 | Apr 23, 2015, 04:43 PM |
| SCHIMMEL PAUL | Director | Mar 19, 2015 | Option Exercise | $27.28 | 9,053 | 246,966 | 9,053 | Mar 19, 2015, 06:49 PM |
| SCHIMMEL PAUL | Director | Mar 17, 2015 | Option Exercise | $27.28 | 947 | 25,834 | 947 | Mar 19, 2015, 06:49 PM |
| SCHIMMEL PAUL | Director | Mar 19, 2015 | Sale | $120.00 | 9,053 | 1,086,360 | 0 | Mar 19, 2015, 06:49 PM |
| SCHIMMEL PAUL | Director | Mar 17, 2015 | Sale | $120.00 | 947 | 113,640 | 0 | Mar 19, 2015, 06:49 PM |
| Ausiello Dennis A | Director | Mar 19, 2015 | Sale | $120.00 | 5,000 | 600,000 | 8,165 | Mar 19, 2015, 06:44 PM |
| Vaishnaw Akshay | EVP, R&D, CMO | Mar 17, 2015 | Option Exercise | $8.67 | 8,750 | 75,875 | 8,750 | Mar 19, 2015, 05:30 PM |
| Vaishnaw Akshay | EVP, R&D, CMO | Mar 17, 2015 | Sale | $116.86 | 8,750 | 1,022,568 | 7,526 | Mar 19, 2015, 05:30 PM |
| Ausiello Dennis A | Director | Mar 05, 2015 | Option Exercise | $63.86 | 706 | 45,085 | 13,871 | Mar 06, 2015, 04:18 PM |
| Ausiello Dennis A | Director | Mar 05, 2015 | Sale | $115.00 | 706 | 81,190 | 13,165 | Mar 06, 2015, 04:18 PM |
| Fanucci Marsha | Director | Feb 25, 2015 | Sale | $105.80 | 10,000 | 1,057,953 | 6,346 | Feb 27, 2015, 04:15 PM |
| Sanofi | 10% Owner | Jan 29, 2015 | Buy | $95.00 | 97,118 | 9,226,210 | 10,051,603 | Feb 02, 2015, 01:10 PM |
| Sanofi | 10% Owner | Jan 22, 2015 | Buy | $93.17 | 196,251 | 18,284,705 | 9,307,037 | Feb 02, 2015, 11:53 AM |
| MARAGANORE JOHN | Chief Executive Officer | Jan 26, 2015 | Buy | $95.00 | 10,000 | 950,000 | 122,825 | Jan 28, 2015, 05:19 PM |
| PAUL STEVEN M | Director | Jan 26, 2015 | Buy | $95.00 | 1,000 | 95,000 | 1,000 | Jan 28, 2015, 05:10 PM |
| Sanofi | 10% Owner | Jan 26, 2015 | Buy | $95.00 | 647,448 | 61,507,560 | 9,954,485 | Jan 28, 2015, 06:51 AM |
| Sanofi | 10% Owner | Jan 22, 2015 | Buy | $9317.00 | 196,251 | 1,828,470,567 | 9,307,037 | Jan 28, 2015, 06:51 AM |
| Reid Laurence | SVP, Chief Business Officer | Dec 31, 2014 | Option Exercise | $97.00 | 2,802 | 271,794 | 18,103 | Jan 05, 2015, 05:10 PM |
| Reid Laurence | SVP, Chief Business Officer | Dec 31, 2014 | Option Exercise | $15.99 | 17,000 | 271,830 | 20,905 | Jan 05, 2015, 05:10 PM |
| Greene Barry E | President and COO | Dec 22, 2014 | Option Exercise | $13.12 | 1,000 | 13,120 | 23,392 | Dec 22, 2014, 05:30 PM |
| Greene Barry E | President and COO | Dec 19, 2014 | Sale | $100.00 | 11,200 | 1,120,000 | 22,392 | Dec 22, 2014, 05:30 PM |
| MARAGANORE JOHN | Chief Executive Officer | Dec 15, 2014 | Option Exercise | $9.14 | 8,205 | 74,994 | 112,825 | Dec 16, 2014, 07:44 PM |
| Vaishnaw Akshay | EVP, Chief Medical Officer | Dec 16, 2014 | Option Exercise | $8.75 | 10,626 | 93,022 | 10,626 | Dec 16, 2014, 07:33 PM |
| Vaishnaw Akshay | EVP, Chief Medical Officer | Dec 16, 2014 | Sale | $93.60 | 10,626 | 994,588 | 10,026 | Dec 16, 2014, 07:33 PM |
| Mason Michael | VP, Finance and Treasurer | Dec 15, 2014 | Option Exercise | $11.50 | 20,625 | 237,117 | 22,162 | Dec 16, 2014, 07:07 PM |
| Mason Michael | VP, Finance and Treasurer | Dec 15, 2014 | Sale | $97.50 | 22,162 | 2,160,808 | 13,458 | Dec 16, 2014, 07:07 PM |
| SCHIMMEL PAUL | Director | Dec 08, 2014 | Option Exercise | $22.09 | 15,000 | 331,350 | 15,000 | Dec 10, 2014, 04:39 PM |
| SCHIMMEL PAUL | Director | Dec 08, 2014 | Sale | $105.00 | 15,000 | 1,575,000 | 0 | Dec 10, 2014, 04:39 PM |
| Ausiello Dennis A | Director | Dec 08, 2014 | Option Exercise | $30.09 | 15,000 | 451,350 | 28,165 | Dec 10, 2014, 04:33 PM |
| Ausiello Dennis A | Director | Dec 08, 2014 | Sale | $108.33 | 15,000 | 1,625,000 | 23,165 | Dec 10, 2014, 04:33 PM |
| Reid Laurence | SVP, Chief Business Officer | Nov 18, 2014 | Option Exercise | $11.12 | 10,000 | 111,227 | 13,905 | Nov 19, 2014, 06:12 PM |
| Reid Laurence | SVP, Chief Business Officer | Nov 18, 2014 | Sale | $90.67 | 10,000 | 906,670 | 8,492 | Nov 19, 2014, 06:12 PM |
| Greene Barry E | President and COO | Nov 17, 2014 | Option Exercise | $6.78 | 33,200 | 225,096 | 66,792 | Nov 19, 2014, 05:52 PM |
| Greene Barry E | President and COO | Nov 17, 2014 | Sale | $89.63 | 33,200 | 2,975,780 | 48,733 | Nov 19, 2014, 05:52 PM |
| Greene Barry E | President and COO | Nov 11, 2014 | Option Exercise | $6.78 | 11,100 | 75,258 | 44,692 | Nov 13, 2014, 05:05 PM |
| Greene Barry E | President and COO | Nov 11, 2014 | Sale | $100.00 | 11,100 | 1,110,000 | 33,592 | Nov 13, 2014, 05:05 PM |
| Ausiello Dennis A | Director | Nov 11, 2014 | Option Exercise | $30.09 | 5,000 | 150,450 | 18,165 | Nov 13, 2014, 04:43 PM |
| Ausiello Dennis A | Director | Nov 11, 2014 | Sale | $100.00 | 5,000 | 500,000 | 13,165 | Nov 13, 2014, 04:43 PM |
| SCHIMMEL PAUL | Director | Oct 28, 2014 | Option Exercise | $15.91 | 15,000 | 238,650 | 15,000 | Oct 30, 2014, 05:03 PM |
| SCHIMMEL PAUL | Director | Oct 28, 2014 | Sale | $95.00 | 15,000 | 1,425,000 | 0 | Oct 30, 2014, 05:03 PM |
| Ausiello Dennis A | Director | Oct 22, 2014 | Option Exercise | $30.09 | 5,000 | 150,450 | 18,165 | Oct 24, 2014, 04:14 PM |
| Ausiello Dennis A | Director | Oct 22, 2014 | Sale | $90.00 | 5,000 | 450,000 | 13,165 | Oct 24, 2014, 04:14 PM |
| SHARP PHILIP A | Director | Oct 13, 2014 | Option Exercise | $7.71 | 110,000 | 847,800 | 184,996 | Oct 15, 2014, 04:54 PM |
| SHARP PHILIP A | Director | Oct 13, 2014 | Sale | $85.00 | 110,000 | 9,350,000 | 74,996 | Oct 15, 2014, 04:54 PM |
| STARR KEVIN P | Director | Sep 25, 2014 | Option Exercise | $21.97 | 45,000 | 988,500 | 45,000 | Sep 26, 2014, 04:31 PM |
| STARR KEVIN P | Director | Sep 24, 2014 | Option Exercise | $11.73 | 45,000 | 527,650 | 45,000 | Sep 26, 2014, 04:31 PM |
| STARR KEVIN P | Director | Sep 24, 2014 | Sale | $79.08 | 45,000 | 3,558,557 | 41,300 | Sep 26, 2014, 04:31 PM |
| STARR KEVIN P | Director | Sep 25, 2014 | Sale | $77.11 | 45,000 | 3,469,881 | 37,601 | Sep 26, 2014, 04:31 PM |
| MARAGANORE JOHN | Chief Executive Officer | Sep 18, 2014 | Option Exercise | $7.47 | 56,834 | 424,550 | 161,454 | Sep 19, 2014, 06:21 PM |
| MARAGANORE JOHN | Chief Executive Officer | Sep 17, 2014 | Option Exercise | $7.47 | 56,834 | 424,550 | 161,454 | Sep 19, 2014, 06:21 PM |
| MARAGANORE JOHN | Chief Executive Officer | Sep 18, 2014 | Sale | $78.86 | 56,834 | 4,481,823 | 142,492 | Sep 19, 2014, 06:21 PM |
| MARAGANORE JOHN | Chief Executive Officer | Sep 17, 2014 | Sale | $76.55 | 56,834 | 4,350,750 | 158,054 | Sep 19, 2014, 06:21 PM |
| Vaishnaw Akshay | EVP, Chief Medical Officer | Sep 16, 2014 | Option Exercise | $8.75 | 10,625 | 93,013 | 10,625 | Sep 17, 2014, 06:25 PM |
| Vaishnaw Akshay | EVP, Chief Medical Officer | Sep 16, 2014 | Sale | $72.04 | 10,625 | 765,463 | 7,425 | Sep 17, 2014, 06:25 PM |
| Reid Laurence | SVP, Chief Business Officer | Aug 18, 2014 | Option Exercise | $8.76 | 13,500 | 118,290 | 17,405 | Aug 20, 2014, 06:45 PM |
| Reid Laurence | SVP, Chief Business Officer | Aug 18, 2014 | Sale | $67.34 | 13,500 | 909,030 | 10,905 | Aug 20, 2014, 06:45 PM |
| MARAGANORE JOHN | Chief Executive Officer | Jun 26, 2014 | Option Exercise | $7.47 | 56,834 | 424,550 | 163,154 | Jun 27, 2014, 04:47 PM |
| MARAGANORE JOHN | Chief Executive Officer | Jun 25, 2014 | Option Exercise | $7.47 | 56,834 | 424,550 | 163,154 | Jun 27, 2014, 04:47 PM |
| MARAGANORE JOHN | Chief Executive Officer | Jun 26, 2014 | Sale | $64.80 | 56,834 | 3,682,926 | 113,690 | Jun 27, 2014, 04:47 PM |
| MARAGANORE JOHN | Chief Executive Officer | Jun 25, 2014 | Sale | $66.11 | 56,834 | 3,757,171 | 139,166 | Jun 27, 2014, 04:47 PM |
| Vaishnaw Akshay | EVP, Chief Medical Officer | Jun 17, 2014 | Option Exercise | $8.75 | 10,625 | 93,013 | 10,625 | Jun 19, 2014, 04:38 PM |
| Vaishnaw Akshay | EVP, Chief Medical Officer | Jun 17, 2014 | Sale | $69.82 | 10,625 | 741,798 | 8,127 | Jun 19, 2014, 04:38 PM |
| CLARKE JOHN K | Director | May 21, 2014 | Option Exercise | $13.05 | 35,000 | 456,850 | 35,000 | May 23, 2014, 04:23 PM |
| CLARKE JOHN K | Director | May 21, 2014 | Sale | $53.80 | 35,000 | 1,882,979 | 12,208 | May 23, 2014, 04:23 PM |
| Reid Laurence | SVP, Chief Business Officer | May 19, 2014 | Option Exercise | $8.76 | 13,500 | 118,290 | 17,405 | May 21, 2014, 04:32 PM |
| Reid Laurence | SVP, Chief Business Officer | May 19, 2014 | Sale | $57.83 | 13,500 | 780,684 | 14,805 | May 21, 2014, 04:32 PM |
| MARAGANORE JOHN | Chief Executive Officer | May 15, 2014 | Option Exercise | $7.06 | 56,834 | 400,973 | 163,154 | May 16, 2014, 04:59 PM |
| MARAGANORE JOHN | Chief Executive Officer | May 14, 2014 | Option Exercise | $6.78 | 56,834 | 385,335 | 163,154 | May 16, 2014, 04:59 PM |
| MARAGANORE JOHN | Chief Executive Officer | May 15, 2014 | Sale | $56.10 | 56,834 | 3,188,227 | 109,246 | May 16, 2014, 04:59 PM |
| MARAGANORE JOHN | Chief Executive Officer | May 14, 2014 | Sale | $57.36 | 56,834 | 3,259,715 | 125,820 | May 16, 2014, 04:59 PM |
| MARAGANORE JOHN | CEO | Apr 14, 2014 | Option Exercise | $18.29 | 28,707 | 524,962 | 106,320 | Apr 15, 2014, 04:43 PM |
| Sanofi | 10% Owner | Mar 25, 2014 | Buy | $66.88 | 344,448 | 23,036,681 | 9,110,786 | Mar 27, 2014, 10:56 AM |
| Vaishnaw Akshay | EVP, Chief Medical Officer | Mar 18, 2014 | Option Exercise | $11.60 | 32,769 | 380,002 | 32,769 | Mar 20, 2014, 05:18 PM |
| Vaishnaw Akshay | EVP, Chief Medical Officer | Mar 18, 2014 | Sale | $73.95 | 32,769 | 2,423,223 | 23,988 | Mar 20, 2014, 05:18 PM |
| Vaishnaw Akshay | EVP, Chief Medical Officer | Feb 21, 2014 | Option Exercise | $90.10 | 2,615 | 235,611 | 0 | Feb 25, 2014, 05:54 PM |
| Reid Laurence | SVP, Chief Business Officer | Feb 19, 2014 | Option Exercise | $9.40 | 13,500 | 126,965 | 24,305 | Feb 20, 2014, 05:00 PM |
| Reid Laurence | SVP, Chief Business Officer | Feb 19, 2014 | Sale | $80.06 | 20,400 | 1,633,240 | 21,226 | Feb 20, 2014, 05:00 PM |
| Mason Michael | VP, Finance and Treasurer | Feb 03, 2014 | Sale | $78.66 | 3,750 | 294,992 | 3,747 | Feb 04, 2014, 05:51 PM |
| Greene Barry E | President and COO | Feb 03, 2014 | Option Exercise | $78.68 | 1,680 | 132,182 | 33,592 | Feb 04, 2014, 05:41 PM |
| Greene Barry E | President and COO | Feb 03, 2014 | Option Exercise | $6.78 | 19,500 | 132,210 | 35,272 | Feb 04, 2014, 05:41 PM |
| MARAGANORE JOHN | CEO | Feb 03, 2014 | Option Exercise | $6.78 | 46,331 | 314,124 | 77,613 | Feb 04, 2014, 05:27 PM |
| Mason Michael | VP, Finance and Tresurer | Jan 23, 2014 | Option Exercise | $89.49 | 2,560 | 229,094 | 5,287 | Jan 27, 2014, 04:46 PM |
| Reid Laurence | SVP, Chief Business Officer | Jan 23, 2014 | Option Exercise | $89.49 | 3,698 | 330,934 | 10,805 | Jan 27, 2014, 04:35 PM |
| Vaishnaw Akshay | EVP, Chief Medical Officer | Jan 23, 2014 | Option Exercise | $89.49 | 4,698 | 420,424 | 7,890 | Jan 27, 2014, 04:26 PM |
| Vaishnaw Akshay | EVP, Chief Medical Officer | Jan 24, 2014 | Sale | $85.75 | 7,890 | 676,589 | 6,021 | Jan 27, 2014, 04:26 PM |
| SCHIMMEL PAUL | Director | Jan 13, 2014 | Option Exercise | $15.82 | 15,000 | 237,300 | 15,000 | Jan 14, 2014, 05:20 PM |
| SCHIMMEL PAUL | Director | Jan 13, 2014 | Sale | $85.36 | 15,000 | 1,280,400 | 0 | Jan 14, 2014, 05:20 PM |
| Reid Laurence | SVP, Chief Business Officer | Dec 30, 2013 | Option Exercise | $64.51 | 930 | 59,994 | 14,503 | Jan 02, 2014, 05:36 PM |
| Reid Laurence | SVP, Chief Business Officer | Dec 30, 2013 | Option Exercise | $15.99 | 3,752 | 59,994 | 15,433 | Jan 02, 2014, 05:36 PM |
| SCHIMMEL PAUL | Director | Dec 20, 2013 | Option Exercise | $11.33 | 15,000 | 169,950 | 15,000 | Dec 23, 2013, 04:56 PM |
| SCHIMMEL PAUL | Director | Dec 20, 2013 | Sale | $65.00 | 15,000 | 975,000 | 0 | Dec 23, 2013, 04:56 PM |
| Mason Michael | VP, Finance and Treasurer | Dec 16, 2013 | Option Exercise | $12.56 | 8,000 | 100,510 | 15,847 | Dec 18, 2013, 07:26 PM |
| Mason Michael | VP, Finance and Treasurer | Dec 16, 2013 | Sale | $60.36 | 8,000 | 482,872 | 10,047 | Dec 18, 2013, 07:26 PM |
| Vaishnaw Akshay | EVP, Chief Medical Officer | Dec 16, 2013 | Option Exercise | $8.53 | 15,000 | 127,900 | 27,588 | Dec 18, 2013, 07:04 PM |
| Vaishnaw Akshay | EVP, Chief Medical Officer | Dec 17, 2013 | Option Exercise | $12.96 | 18,480 | 239,501 | 31,068 | Dec 18, 2013, 07:04 PM |
| Vaishnaw Akshay | EVP, Chief Medical Officer | Dec 17, 2013 | Sale | $61.03 | 18,480 | 1,127,761 | 22,568 | Dec 18, 2013, 07:04 PM |
| Vaishnaw Akshay | EVP, Chief Medical Officer | Dec 16, 2013 | Sale | $60.35 | 15,000 | 905,298 | 16,844 | Dec 18, 2013, 07:04 PM |
| Greene Barry E | President and COO | Dec 17, 2013 | Option Exercise | $6.78 | 11,200 | 75,936 | 15,772 | Dec 18, 2013, 06:34 PM |
| Mason Michael | VP, Finance and Treasurer | Dec 02, 2013 | Option Exercise | $7.10 | 3,750 | 26,625 | 11,597 | Dec 04, 2013, 05:01 PM |
| Mason Michael | VP, Finance and Treasurer | Dec 02, 2013 | Sale | $61.83 | 3,750 | 231,863 | 9,692 | Dec 04, 2013, 05:01 PM |
| Reid Laurence | SVP, Chief Business Officer | Nov 13, 2013 | Option Exercise | $15.99 | 13,500 | 215,865 | 25,181 | Nov 15, 2013, 04:53 PM |
| Reid Laurence | SVP, Chief Business Officer | Nov 13, 2013 | Sale | $53.36 | 13,500 | 720,302 | 11,681 | Nov 15, 2013, 04:53 PM |
| SCHIMMEL PAUL | Director | Oct 22, 2013 | Option Exercise | $9.30 | 15,000 | 139,500 | 141,216 | Oct 24, 2013, 05:23 PM |
| SCHIMMEL PAUL | Director | Oct 22, 2013 | Sale | $60.00 | 15,000 | 900,000 | 126,216 | Oct 24, 2013, 05:23 PM |
| MARAGANORE JOHN | Chief Executive Officer | Oct 10, 2013 | Option Exercise | $6.78 | 12,665 | 85,869 | 31,282 | Oct 15, 2013, 05:29 PM |
| MARAGANORE JOHN | Chief Executive Officer | Sep 11, 2013 | Option Exercise | $0.95 | 58,947 | 56,000 | 77,564 | Sep 12, 2013, 05:32 PM |
| MARAGANORE JOHN | Chief Executive Officer | Sep 11, 2013 | Sale | $55.50 | 58,947 | 3,271,524 | 23,517 | Sep 12, 2013, 05:32 PM |
| Vaishnaw Akshay | EVP, Chief Medical Officer | Sep 10, 2013 | Option Exercise | $9.30 | 6,250 | 58,125 | 18,838 | Sep 12, 2013, 04:57 PM |
| Vaishnaw Akshay | EVP, Chief Medical Officer | Sep 10, 2013 | Sale | $57.48 | 6,250 | 359,238 | 13,288 | Sep 12, 2013, 04:57 PM |
| MARAGANORE JOHN | Chief Executive Officer | Aug 14, 2013 | Option Exercise | $0.95 | 60,000 | 57,000 | 78,617 | Aug 16, 2013, 04:19 PM |
| MARAGANORE JOHN | Chief Executive Officer | Aug 14, 2013 | Sale | $48.97 | 60,000 | 2,938,126 | 58,854 | Aug 16, 2013, 04:19 PM |
| Mason Michael | VP, Finance & Treasurer | Jul 12, 2013 | Option Exercise | $31.39 | 14,200 | 445,738 | 22,047 | Jul 12, 2013, 05:44 PM |
| Mason Michael | VP, Finance & Treasurer | Jul 12, 2013 | Sale | $50.00 | 14,200 | 710,000 | 7,847 | Jul 12, 2013, 05:44 PM |
| MARAGANORE JOHN | Chief Executive Officer | Jul 10, 2013 | Option Exercise | $0.95 | 60,000 | 57,000 | 78,617 | Jul 12, 2013, 05:23 PM |
| MARAGANORE JOHN | Chief Executive Officer | Jul 10, 2013 | Sale | $37.11 | 60,000 | 2,226,822 | 18,617 | Jul 12, 2013, 05:23 PM |
| Mason Michael | VP, Finance and Treasurer | Jul 01, 2013 | Option Exercise | $22.13 | 27,000 | 597,450 | 22,847 | Jul 02, 2013, 05:32 PM |
| Mason Michael | VP, Finance and Treasurer | Jul 01, 2013 | Sale | $32.00 | 27,000 | 864,000 | 7,847 | Jul 02, 2013, 05:32 PM |
| Mason Michael | VP, Finance and Treasurer | Jun 17, 2013 | Option Exercise | $13.64 | 23,625 | 322,203 | 20,847 | Jun 19, 2013, 05:34 PM |
| Mason Michael | VP, Finance and Treasurer | Jun 17, 2013 | Sale | $29.93 | 23,625 | 707,160 | 7,847 | Jun 19, 2013, 05:34 PM |
| Vaishnaw Akshay | EVP, Chief Medical Officer | Jun 11, 2013 | Option Exercise | $8.53 | 15,000 | 127,900 | 18,838 | Jun 13, 2013, 05:42 PM |
| Vaishnaw Akshay | EVP, Chief Medical Officer | Jun 11, 2013 | Sale | $31.08 | 15,000 | 466,137 | 12,688 | Jun 13, 2013, 05:42 PM |
| Reid Laurence | SVP and Chief Business Officer | May 28, 2013 | Option Exercise | $7.10 | 5,000 | 35,500 | 16,681 | May 30, 2013, 06:17 PM |
| Reid Laurence | SVP and Chief Business Officer | May 28, 2013 | Sale | $30.00 | 5,000 | 150,000 | 11,681 | May 30, 2013, 06:17 PM |
| Greene Barry E | President and COO | May 28, 2013 | Option Exercise | $0.95 | 22,822 | 21,681 | 19,500 | May 30, 2013, 06:04 PM |
| Greene Barry E | President and COO | May 28, 2013 | Sale | $30.00 | 22,822 | 684,660 | 4,572 | May 30, 2013, 06:04 PM |
| STARR KEVIN P | Director | Mar 26, 2013 | Option Exercise | $0.95 | 26,000 | 24,700 | 26,000 | Mar 26, 2013, 06:53 PM |
| STARR KEVIN P | Director | Mar 25, 2013 | Option Exercise | $0.95 | 26,631 | 25,299 | 26,631 | Mar 26, 2013, 06:53 PM |
| STARR KEVIN P | Director | Mar 26, 2013 | Sale | $23.41 | 26,000 | 608,577 | 0 | Mar 26, 2013, 06:53 PM |
| STARR KEVIN P | Director | Mar 25, 2013 | Sale | $23.56 | 26,631 | 627,557 | 0 | Mar 26, 2013, 06:53 PM |
| Greene Barry E | President & COO | Mar 14, 2013 | Option Exercise | $0.95 | 24,058 | 22,855 | 28,630 | Mar 18, 2013, 06:07 PM |
| Greene Barry E | President & COO | Mar 14, 2013 | Sale | $25.00 | 24,058 | 601,450 | 4,572 | Mar 18, 2013, 06:07 PM |
| Vaishnaw Akshay | EVP, Chief Medical Officer | Mar 11, 2013 | Option Exercise | $9.30 | 6,250 | 58,125 | 18,838 | Mar 11, 2013, 06:54 PM |
| Vaishnaw Akshay | EVP, Chief Medical Officer | Mar 11, 2013 | Sale | $24.55 | 6,250 | 153,415 | 12,588 | Mar 11, 2013, 06:54 PM |
| Greene Barry E | President and COO | Mar 08, 2013 | Option Exercise | $0.95 | 24,000 | 22,800 | 28,572 | Mar 11, 2013, 06:39 PM |
| Greene Barry E | President and COO | Mar 08, 2013 | Sale | $24.43 | 24,000 | 586,270 | 4,572 | Mar 11, 2013, 06:39 PM |
| MARAGANORE JOHN | Chief Executive Officer | Feb 28, 2013 | Sale | $23.50 | 28,503 | 669,900 | 18,617 | Feb 28, 2013, 06:21 PM |
| MARAGANORE JOHN | Chief Executive Officer | Feb 27, 2013 | Sale | $23.47 | 30,000 | 704,019 | 47,120 | Feb 28, 2013, 06:21 PM |
| Reid Laurence | SVP, Chief Business Officer | Feb 08, 2013 | Option Exercise | $7.10 | 5,000 | 35,500 | 16,681 | Feb 12, 2013, 05:44 PM |
| Reid Laurence | SVP, Chief Business Officer | Feb 08, 2013 | Sale | $25.00 | 5,000 | 125,000 | 11,681 | Feb 12, 2013, 05:44 PM |
| SHARP PHILIP A | Director | Jan 22, 2013 | Buy | $20.13 | 4,967 | 99,986 | 14,269 | Jan 24, 2013, 04:48 PM |
| MARAGANORE JOHN | CEO | Dec 19, 2012 | Option Exercise | $0.47 | 18,617 | 8,843 | 77,120 | Dec 21, 2012, 05:17 PM |
| Vaishnaw Akshay | EVP, Chief Medical Officer | Dec 12, 2012 | Option Exercise | $9.24 | 10,000 | 92,400 | 22,588 | Dec 12, 2012, 06:17 PM |
| Vaishnaw Akshay | EVP, Chief Medical Officer | Dec 10, 2012 | Option Exercise | $7.10 | 4,777 | 33,917 | 17,365 | Dec 12, 2012, 06:17 PM |
| Vaishnaw Akshay | EVP, Chief Medical Officer | Dec 12, 2012 | Sale | $19.00 | 10,000 | 190,000 | 12,588 | Dec 12, 2012, 06:17 PM |
| Vaishnaw Akshay | EVP, Chief Medical Officer | Dec 10, 2012 | Sale | $17.00 | 4,777 | 81,209 | 12,588 | Dec 12, 2012, 06:17 PM |
| Vaishnaw Akshay | EVP, Chief Medical Officer | Dec 04, 2012 | Option Exercise | $7.10 | 2,400 | 17,040 | 14,988 | Dec 06, 2012, 04:11 PM |
| Vaishnaw Akshay | EVP, Chief Medical Officer | Dec 04, 2012 | Sale | $17.04 | 2,400 | 40,896 | 12,588 | Dec 06, 2012, 04:11 PM |
| Vaishnaw Akshay | EVP, Chief Medical Officer | Nov 30, 2012 | Option Exercise | $7.10 | 2,823 | 20,043 | 15,411 | Dec 04, 2012, 06:33 PM |
| Vaishnaw Akshay | EVP, Chief Medical Officer | Nov 30, 2012 | Sale | $17.03 | 2,823 | 48,072 | 12,588 | Dec 04, 2012, 06:33 PM |
| Mason Michael | VP, Finance and Treasurer | Nov 30, 2012 | Option Exercise | $7.10 | 3,750 | 26,625 | 11,597 | Dec 04, 2012, 06:19 PM |
| Mason Michael | VP, Finance and Treasurer | Nov 30, 2012 | Sale | $16.93 | 3,750 | 63,472 | 7,847 | Dec 04, 2012, 06:19 PM |
| NOVARTIS AG | 10% Owner | Sep 20, 2012 | Sale | $19.42 | 1,551,896 | 30,137,820 | 4,051,002 | Sep 24, 2012, 06:14 PM |
| Vaishnaw Akshay | EVP, Chief Medical Officer | Sep 10, 2012 | Option Exercise | $9.30 | 1,334 | 12,406 | 13,922 | Sep 12, 2012, 06:55 PM |
| Vaishnaw Akshay | EVP, Chief Medical Officer | Sep 12, 2012 | Option Exercise | $9.30 | 4,916 | 45,719 | 17,504 | Sep 12, 2012, 06:55 PM |
| Vaishnaw Akshay | EVP, Chief Medical Officer | Sep 10, 2012 | Sale | $19.00 | 1,334 | 25,346 | 12,588 | Sep 12, 2012, 06:55 PM |
| Vaishnaw Akshay | EVP, Chief Medical Officer | Sep 12, 2012 | Sale | $19.00 | 4,916 | 93,404 | 12,588 | Sep 12, 2012, 06:55 PM |
| Mason Michael | VP, Finance and Treasurer | Jul 27, 2012 | Option Exercise | $10.98 | 6,250 | 68,625 | 14,097 | Jul 31, 2012, 06:13 PM |
| Mason Michael | VP, Finance and Treasurer | Jul 27, 2012 | Sale | $20.00 | 6,250 | 125,000 | 7,847 | Jul 31, 2012, 06:13 PM |
| Vaishnaw Akshay | SVP, Chief Medical Officer | Jul 16, 2012 | Option Exercise | $9.25 | 36,250 | 335,325 | 37,588 | Jul 18, 2012, 06:37 PM |
| Vaishnaw Akshay | SVP, Chief Medical Officer | Jul 16, 2012 | Sale | $19.00 | 36,250 | 688,750 | 12,588 | Jul 18, 2012, 06:37 PM |
| Mason Michael | VP, Finance & Treasurer | Jul 16, 2012 | Option Exercise | $11.41 | 15,295 | 174,554 | 16,580 | Jul 18, 2012, 06:02 PM |
| Mason Michael | VP, Finance & Treasurer | Jul 16, 2012 | Sale | $18.57 | 15,295 | 284,043 | 7,847 | Jul 18, 2012, 06:02 PM |
| SHARP PHILIP A | Director | Feb 21, 2012 | Buy | $10.75 | 9,302 | 99,997 | 9,302 | Feb 23, 2012, 05:19 PM |
| SCHIMMEL PAUL | Director | Feb 21, 2012 | Buy | $10.75 | 93,023 | 999,997 | 252,111 | Feb 23, 2012, 05:11 PM |
| Fanucci Marsha | Director | Feb 21, 2012 | Buy | $10.75 | 10,000 | 107,500 | 10,000 | Feb 23, 2012, 05:06 PM |
| Reid Laurence | SVP, Chief Business Officer | Feb 21, 2012 | Buy | $10.75 | 930 | 9,998 | 11,681 | Feb 23, 2012, 05:00 PM |
| Greene Barry E | President and COO | Feb 21, 2012 | Buy | $10.75 | 1,860 | 19,995 | 4,572 | Feb 23, 2012, 04:53 PM |
| MARAGANORE JOHN | CEO | Feb 21, 2012 | Buy | $10.75 | 5,581 | 59,996 | 58,503 | Feb 23, 2012, 04:43 PM |
| Greene Barry E | President and COO | Jan 09, 2012 | Buy | $8.80 | 567 | 4,992 | 2,712 | Jan 11, 2012, 04:58 PM |
| MARAGANORE JOHN | CEO | Jan 09, 2012 | Buy | $8.81 | 1,134 | 9,995 | 52,922 | Jan 11, 2012, 04:47 PM |
| Greene Barry E | President and COO | Dec 12, 2011 | Buy | $7.15 | 699 | 4,995 | 2,145 | Dec 14, 2011, 04:37 PM |
| MARAGANORE JOHN | CEO | Dec 12, 2011 | Buy | $7.15 | 1,397 | 9,995 | 51,788 | Dec 14, 2011, 04:26 PM |
| Greene Barry E | President and COO | Nov 14, 2011 | Buy | $7.09 | 704 | 4,994 | 1,446 | Nov 16, 2011, 04:42 PM |
| MARAGANORE JOHN | CEO | Nov 14, 2011 | Buy | $7.08 | 1,411 | 9,997 | 50,391 | Nov 16, 2011, 04:34 PM |
| Greene Barry E | President and COO | Oct 11, 2011 | Buy | $6.73 | 742 | 4,996 | 742 | Oct 13, 2011, 05:09 PM |
| MARAGANORE JOHN | CEO | Oct 11, 2011 | Buy | $6.75 | 1,480 | 9,989 | 48,980 | Oct 13, 2011, 04:57 PM |
| MARAGANORE JOHN | CEO | Aug 17, 2010 | Option Exercise | $0.47 | 50,000 | 23,750 | 50,000 | Aug 18, 2010, 04:48 PM |
Load More Insider Transactions
Buy
Sale
Option Exercise
| Owner | Relationship | Date | Value($) |
| Greenstreet Yvonne | Chief Executive Officer | 08/20/2024 | 1,275,000 |
| Greenstreet Yvonne | Chief Executive Officer | 08/20/2024 | 4,200,000 |
| Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | 08/12/2024 | 1,846,429 |
| Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | 08/12/2024 | 5,968,516 |
| Ausiello Dennis A | Director | 08/06/2024 | 2,423,453 |
| Ausiello Dennis A | Director | 08/06/2024 | 5,305,587 |
| Greenstreet Yvonne | Chief Executive Officer | 08/01/2024 | 1,287,580 |
| Greenstreet Yvonne | Chief Executive Officer | 08/01/2024 | 4,089,960 |
| Greenstreet Yvonne | Chief Executive Officer | 07/11/2024 | 1,851,273 |
| SCHULMAN AMY W | Director | 06/25/2024 | 1,115,285 |
| SCHULMAN AMY W | Director | 06/25/2024 | 2,040,000 |
| PYOTT DAVID E I | Director | 06/24/2024 | 2,620,611 |
| PYOTT DAVID E I | Director | 06/24/2024 | 7,161,360 |
| Garg Pushkal | CMO & EVP Dev & Med Affairs | 06/25/2024 | 485,773 |
| Greenstreet Yvonne | Chief Executive Officer | 06/25/2024 | 1,917,475 |
| Poulton Jeffrey V. | EVP, Chief Financial Officer | 06/25/2024 | 370,747 |
| Tanguler Tolga | EVP, Chief Commercial Officer | 06/25/2024 | 370,747 |
| Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | 06/25/2024 | 276,731 |
| SCHULMAN AMY W | Director | 05/29/2024 | 2,004,900 |
| SCHULMAN AMY W | Director | 05/29/2024 | 3,224,546 |
| SHARP PHILLIP A | Director | 02/29/2024 | 1,777,500 |
| SHARP PHILLIP A | Director | 02/29/2024 | 4,540,071 |
| Tanguler Tolga | EVP, Chief Commercial Officer | 02/28/2024 | 77,805 |
| Poulton Jeffrey V. | EVP, Chief Financial Officer | 02/28/2024 | 89,145 |
| Greenstreet Yvonne | Chief Executive Officer | 02/28/2024 | 455,357 |
| Garg Pushkal | CMO & EVP Dev & Med Affairs | 02/28/2024 | 89,145 |
| Franchini Indrani Lall | EVP, CLO & Secretary | 02/28/2024 | 51,094 |
| Garg Pushkal | CMO & EVP Dev & Med Affairs | 02/16/2024 | 193,666 |
| Poulton Jeffrey V. | EVP, Chief Financial Officer | 02/16/2024 | 149,099 |
| Tanguler Tolga | EVP, Chief Commercial Officer | 02/16/2024 | 149,397 |
| Greenstreet Yvonne | Chief Executive Officer | 02/16/2024 | 1,040,885 |
| Franchini Indrani Lall | EVP, CLO & Secretary | 02/02/2024 | 272,050 |
| BONNEY MICHAEL W | Director | 12/27/2023 | 2,893,500 |
| BONNEY MICHAEL W | Director | 12/27/2023 | 5,850,000 |
| Garg Pushkal | CMO & EVP Dev & Med Affairs | 08/07/2023 | 766,083 |
| Garg Pushkal | CMO & EVP Dev & Med Affairs | 08/04/2023 | 643,223 |
| Poulton Jeffrey V. | EVP, Chief Financial Officer | 08/04/2023 | 643,037 |
| Greenstreet Yvonne | Chief Executive Officer | 08/04/2023 | 753,986 |
| Vaishnaw Akshay | President | 08/04/2023 | 753,986 |
| BONNEY MICHAEL W | Director | 08/03/2023 | 1,195,310 |
| Greenstreet Yvonne | Chief Executive Officer | 04/27/2023 | 1,481,811 |
| Poulton Jeffrey V. | EVP, Chief Financial Officer | 04/27/2023 | 190,113 |
| Tanguler Tolga | EVP, Chief Commercial Officer | 04/27/2023 | 287,215 |
| Vaishnaw Akshay | President | 04/27/2023 | 465,464 |
| Garg Pushkal | CMO & EVP Dev & Med Affairs | 04/28/2023 | 488,595 |
| Garg Pushkal | CMO & EVP Dev & Med Affairs | 04/27/2023 | 357,855 |
| Franchini Indrani Lall | EVP, CLO & Secretary | 04/06/2023 | 735,000 |
| Garg Pushkal | CMO & EVP Dev & Med Affairs | 03/03/2023 | 482,250 |
| Garg Pushkal | CMO & EVP Dev & Med Affairs | 03/03/2023 | 3,614,400 |
| Franchini Indrani Lall | EVP, CLO & Secretary | 02/02/2023 | 378,563 |
| Tanguler Tolga | EVP, Chief Commercial Officer | 02/02/2023 | 361,839 |
| Tanguler Tolga | EVP, Chief Commercial Officer | 02/03/2023 | 794,854 |
| Vaishnaw Akshay | President | 12/05/2022 | 299,489 |
| Vaishnaw Akshay | President | 12/05/2022 | 299,938 |
| Ausiello Dennis A | Director | 11/21/2022 | 1,599,637 |
| Ausiello Dennis A | Director | 11/21/2022 | 4,950,000 |
| Tanguler Tolga | EVP, Chief Commercial Officer | 08/04/2022 | 342,817 |
| Tanguler Tolga | EVP, Chief Commercial Officer | 08/03/2022 | 368,340 |
| Tanguler Tolga | EVP, Chief Commercial Officer | 08/05/2022 | 401,630 |
| Poulton Jeffrey V. | EVP, Chief Financial Officer | 08/04/2022 | 968,824 |
| Garg Pushkal | CMO & EVP Dev & Med Affairs | 08/04/2022 | 974,201 |
| Vaishnaw Akshay | President | 08/04/2022 | 1,160,335 |
| Greenstreet Yvonne | Chief Executive Officer | 08/04/2022 | 1,150,439 |
| Tanguler Tolga | EVP, Chief Commercial Officer | 07/05/2022 | 263,100 |
| PAUL STEVEN M | Director | 04/01/2022 | 169,950 |
| PAUL STEVEN M | Director | 04/01/2022 | 2,560,371 |
| SHARP PHILLIP A | Director | 02/09/2022 | 339,900 |
| SHARP PHILLIP A | Director | 02/09/2022 | 4,500,000 |
| Tanguler Tolga | EVP, Chief Commercial Officer | 02/02/2022 | 219,609 |
| Vaishnaw Akshay | President, R&D | 12/22/2021 | 479,690 |
| Vaishnaw Akshay | President, R&D | 12/23/2021 | 549,698 |
| MARAGANORE JOHN | Chief Executive Officer | 12/22/2021 | 1,254,077 |
| Greenstreet Yvonne | President & COO | 12/22/2021 | 479,699 |
| MARAGANORE JOHN | Chief Executive Officer | 12/10/2021 | 399,829 |
| MARAGANORE JOHN | Chief Executive Officer | 11/12/2021 | 241,244 |
| MARAGANORE JOHN | Chief Executive Officer | 11/12/2021 | 5,827,801 |
| MARAGANORE JOHN | Chief Executive Officer | 08/13/2021 | 241,251 |
| MARAGANORE JOHN | Chief Executive Officer | 08/13/2021 | 6,788,196 |
| Vaishnaw Akshay | President, R&D | 08/09/2021 | 682,542 |
| Vaishnaw Akshay | President, R&D | 08/09/2021 | 2,166,800 |
| KEATING LAURIE | EVP, Chief Legal Officer | 08/05/2021 | 889,500 |
| KEATING LAURIE | EVP, Chief Legal Officer | 08/05/2021 | 1,889,500 |
| Greenstreet Yvonne | President & COO | 08/06/2021 | 4,091,234 |
| Greenstreet Yvonne | President & COO | 08/06/2021 | 10,559,736 |
| KEATING LAURIE | EVP, Chief Legal Officer | 07/12/2021 | 598,770 |
| KEATING LAURIE | EVP, Chief Legal Officer | 07/12/2021 | 1,219,098 |
| MARAGANORE JOHN | Chief Executive Officer | 05/13/2021 | 241,251 |
| MARAGANORE JOHN | Chief Executive Officer | 05/13/2021 | 4,443,725 |
| KEATING LAURIE | EVP, Chief Legal Officer | 04/20/2021 | 275,426 |
| MARAGANORE JOHN | Chief Executive Officer | 04/20/2021 | 989,822 |
| MARAGANORE JOHN | Chief Executive Officer | 02/25/2021 | 241,251 |
| MARAGANORE JOHN | Chief Executive Officer | 02/25/2021 | 5,005,421 |
| Vaishnaw Akshay | President, R&D | 02/12/2021 | 266,441 |
| Greenstreet Yvonne | President & COO | 02/12/2021 | 303,403 |
| KEATING LAURIE | EVP, Chief Legal Officer | 02/12/2021 | 305,967 |
| MARAGANORE JOHN | Chief Executive Officer | 02/12/2021 | 890,917 |
| KEATING LAURIE | EVP, Chief Legal Officer | 01/13/2021 | 744,290 |
| KEATING LAURIE | EVP, Chief Legal Officer | 01/13/2021 | 1,533,698 |
| KEATING LAURIE | EVP, Chief Legal Officer | 01/12/2021 | 1,088,149 |
| KEATING LAURIE | EVP, Chief Legal Officer | 01/12/2021 | 2,393,619 |
| KEATING LAURIE | EVP, Chief Legal Officer | 01/11/2021 | 116,732 |
| Greenstreet Yvonne | President & COO | 01/12/2021 | 131,938 |
| Greenstreet Yvonne | President & COO | 01/12/2021 | 503,125 |
| PAUL STEVEN M | Director | 12/18/2020 | 139,500 |
| PAUL STEVEN M | Director | 12/18/2020 | 2,100,000 |
| SHARP PHILLIP A | Director | 11/25/2020 | 279,000 |
| SHARP PHILLIP A | Director | 11/25/2020 | 3,746,749 |
| MARAGANORE JOHN | Chief Executive Officer | 11/19/2020 | 317,752 |
| MARAGANORE JOHN | Chief Executive Officer | 11/19/2020 | 4,319,025 |
| Vaishnaw Akshay | President, R&D | 09/29/2020 | 40,996 |
| Vaishnaw Akshay | President, R&D | 09/29/2020 | 135,940 |
| Greene Barry E | President | 09/09/2020 | 407,004 |
| Greene Barry E | President | 09/09/2020 | 5,487,595 |
| MARAGANORE JOHN | Chief Executive Officer | 08/20/2020 | 317,752 |
| MARAGANORE JOHN | Chief Executive Officer | 08/20/2020 | 4,732,542 |
| Greene Barry E | President | 08/10/2020 | 349,871 |
| KEATING LAURIE | EVP, Chief Legal Officer | 07/13/2020 | 3,116,066 |
| KEATING LAURIE | EVP, Chief Legal Officer | 07/13/2020 | 7,591,791 |
| Greenstreet Yvonne | Chief Operating Officer | 07/10/2020 | 3,595,867 |
| Greenstreet Yvonne | Chief Operating Officer | 07/10/2020 | 7,508,879 |
| Greenstreet Yvonne | Chief Operating Officer | 07/09/2020 | 484,743 |
| Greenstreet Yvonne | Chief Operating Officer | 07/09/2020 | 1,808,996 |
| Greene Barry E | President | 07/07/2020 | 203,502 |
| Greene Barry E | President | 07/07/2020 | 3,562,177 |
| Vaishnaw Akshay | President, R&D | 06/22/2020 | 40,953 |
| Vaishnaw Akshay | President, R&D | 06/22/2020 | 146,536 |
| MARAGANORE JOHN | Chief Executive Officer | 05/20/2020 | 317,752 |
| MARAGANORE JOHN | Chief Executive Officer | 05/20/2020 | 4,978,983 |
| Greene Barry E | President | 05/06/2020 | 203,502 |
| Greene Barry E | President | 05/06/2020 | 3,339,527 |
| Greenstreet Yvonne | Chief Operating Officer | 05/06/2020 | 3,855,000 |
| Greenstreet Yvonne | Chief Operating Officer | 05/05/2020 | 329,780 |
| Greenstreet Yvonne | Chief Operating Officer | 05/06/2020 | 7,500,000 |
| Greenstreet Yvonne | Chief Operating Officer | 05/05/2020 | 1,093,540 |
| KEATING LAURIE | EVP, Chief Legal Officer | 04/20/2020 | 774,000 |
| KEATING LAURIE | EVP, Chief Legal Officer | 04/20/2020 | 1,390,000 |
| Vaishnaw Akshay | President, R&D | 04/20/2020 | 927,616 |
| Vaishnaw Akshay | President, R&D | 04/20/2020 | 3,075,940 |
| Greene Barry E | President | 04/07/2020 | 174,321 |
| Greenstreet Yvonne | Chief Operating Officer | 04/07/2020 | 263,503 |
| KEATING LAURIE | EVP, Chief Legal Officer | 04/07/2020 | 202,548 |
| MARAGANORE JOHN | Chief Executive Officer | 04/07/2020 | 688,701 |
| Vaishnaw Akshay | President, R&D | 04/07/2020 | 263,410 |
| MARAGANORE JOHN | Chief Executive Officer | 02/20/2020 | 317,752 |
| MARAGANORE JOHN | Chief Executive Officer | 02/20/2020 | 4,583,674 |
| SHARP PHILLIP A | Director | 02/12/2020 | 374,400 |
| SHARP PHILLIP A | Director | 02/12/2020 | 3,900,000 |
| KEATING LAURIE | EVP, Chief Legal Officer | 02/10/2020 | 774,000 |
| KEATING LAURIE | EVP, Chief Legal Officer | 02/10/2020 | 1,290,000 |
| KEATING LAURIE | EVP, Chief Legal Officer | 01/27/2020 | 283,516 |
| PAUL STEVEN M | Director | 02/10/2020 | 440,100 |
| PAUL STEVEN M | Director | 02/10/2020 | 3,900,000 |
| Vaishnaw Akshay | President, R&D | 02/07/2020 | 960,505 |
| Vaishnaw Akshay | President, R&D | 02/07/2020 | 2,963,500 |
| Greenstreet Yvonne | Chief Operating Officer | 02/07/2020 | 263,875 |
| Greenstreet Yvonne | Chief Operating Officer | 02/10/2020 | 236,432 |
| Greenstreet Yvonne | Chief Operating Officer | 02/07/2020 | 774,375 |
| Greenstreet Yvonne | Chief Operating Officer | 02/10/2020 | 1,285,960 |
| KEATING LAURIE | EVP, Chief Legal Officer | 01/29/2020 | 490,484 |
| KEATING LAURIE | EVP, Chief Legal Officer | 01/29/2020 | 754,103 |
| KEATING LAURIE | EVP, Chief Legal Officer | 01/27/2020 | 1,451,270 |
| KEATING LAURIE | EVP, Chief Legal Officer | 01/27/2020 | 4,829,970 |
| Greenstreet Yvonne | Chief Operating Officer | 12/12/2019 | 386,917 |
| Fanucci Marsha | Director | 11/20/2019 | 1,035,000 |
| Fanucci Marsha | Director | 11/20/2019 | 7,500,000 |
| Greenstreet Yvonne | Chief Operating Officer | 11/20/2019 | 354,817 |
| Greenstreet Yvonne | Chief Operating Officer | 11/20/2019 | 882,420 |
| SHARP PHILLIP A | Director | 11/18/2019 | 246,450 |
| SHARP PHILLIP A | Director | 11/18/2019 | 1,375,662 |
| Greene Barry E | President | 10/22/2019 | 967,941 |
| Greene Barry E | President | 10/22/2019 | 5,301,581 |
| MARAGANORE JOHN | Chief Executive Officer | 10/14/2019 | 812,562 |
| MARAGANORE JOHN | Chief Executive Officer | 10/14/2019 | 3,929,210 |
| MARAGANORE JOHN | Chief Executive Officer | 05/15/2019 | 812,579 |
| MARAGANORE JOHN | Chief Executive Officer | 05/15/2019 | 3,461,990 |
| SHARP PHILIP A | Director | 04/15/2019 | 331,350 |
| SHARP PHILIP A | Director | 04/15/2019 | 1,323,442 |
| MARAGANORE JOHN | Chief Executive Officer | 11/21/2018 | 4,356,439 |
| MARAGANORE JOHN | Chief Executive Officer | 11/21/2018 | 2,105,879 |
| Greenstreet Yvonne | EVP, Chief Operating Officer | 08/30/2018 | 300,000 |
| Vaishnaw Akshay | President, R&D | 08/13/2018 | 69,668 |
| Greenstreet Yvonne | EVP, Chief Operating Officer | 08/13/2018 | 280,490 |
| KEATING LAURIE | SVP, GC & Secretary | 08/13/2018 | 55,025 |
| Mason Michael | VP, Finance and Treasurer | 08/13/2018 | 40,837 |
| MARAGANORE JOHN | Chief Executive Officer | 07/25/2018 | 1,067,500 |
| MARAGANORE JOHN | Chief Executive Officer | 07/25/2018 | 5,269,458 |
| KEATING LAURIE | SVP, GC & Secretary | 06/20/2018 | 65,990 |
| KEATING LAURIE | SVP, GC & Secretary | 06/20/2018 | 164,178 |
| CLARKE JOHN K | Director | 05/31/2018 | 409,200 |
| CLARKE JOHN K | Director | 05/31/2018 | 1,504,678 |
| Greenstreet Yvonne | EVP, Chief Operating Officer | 03/26/2018 | 304,871 |
| Greenstreet Yvonne | EVP, Chief Operating Officer | 03/26/2018 | 985,958 |
| KEATING LAURIE | SVP, GC & Secretary | 03/20/2018 | 65,948 |
| KEATING LAURIE | SVP, GC & Secretary | 03/20/2018 | 234,033 |
| Vaishnaw Akshay | President, R&D | 03/14/2018 | 1,507,842 |
| Vaishnaw Akshay | President, R&D | 03/14/2018 | 12,672,126 |
| Greene Barry E | President | 03/14/2018 | 5,503,736 |
| KEATING LAURIE | SVP, GC & Secretary | 03/13/2018 | 774,000 |
| KEATING LAURIE | SVP, GC & Secretary | 03/12/2018 | 774,000 |
| KEATING LAURIE | SVP, GC & Secretary | 03/12/2018 | 1,400,000 |
| KEATING LAURIE | SVP, GC & Secretary | 03/13/2018 | 1,500,000 |
| Ausiello Dennis A | Director | 03/13/2018 | 1,023,942 |
| Ausiello Dennis A | Director | 03/13/2018 | 2,567,550 |
| SHARP PHILIP A | Director | 03/13/2018 | 320,250 |
| SHARP PHILIP A | Director | 03/13/2018 | 2,235,000 |
| SCHIMMEL PAUL | Director | 03/13/2018 | 1,369,927 |
| SCHIMMEL PAUL | Director | 03/13/2018 | 4,173,450 |
| SHARP PHILIP A | Director | 03/09/2018 | 409,200 |
| SHARP PHILIP A | Director | 03/09/2018 | 1,935,000 |
| Mason Michael | VP, Finance and Treasurer | 01/04/2018 | 2,804,910 |
| Mason Michael | VP, Finance and Treasurer | 01/04/2018 | 4,835,171 |
| Mason Michael | VP, Finance and Treasurer | 12/30/2017 | 449,503 |
| KEATING LAURIE | SVP, GC & Secretary | 12/29/2017 | 232,200 |
| KEATING LAURIE | SVP, GC & Secretary | 12/20/2017 | 263,833 |
| KEATING LAURIE | SVP, GC & Secretary | 12/20/2017 | 757,398 |
| MARAGANORE JOHN | Chief Executive Officer | 12/19/2017 | 99,981 |
| KEATING LAURIE | SVP, GC and Secretary | 12/01/2017 | 2,322,000 |
| KEATING LAURIE | SVP, GC and Secretary | 12/01/2017 | 4,076,823 |
| MARAGANORE JOHN | Chief Executive Officer | 11/22/2017 | 2,304,497 |
| MARAGANORE JOHN | Chief Executive Officer | 11/22/2017 | 9,609,737 |
| MARAGANORE JOHN | Chief Executive Officer | 11/15/2017 | 2,322,860 |
| MARAGANORE JOHN | Chief Executive Officer | 11/15/2017 | 9,387,951 |
| Ausiello Dennis A | Director | 11/02/2017 | 601,800 |
| Ausiello Dennis A | Director | 11/02/2017 | 2,600,000 |
| Vaishnaw Akshay | EVP, R&D | 10/30/2017 | 718,769 |
| Vaishnaw Akshay | EVP, R&D | 10/30/2017 | 4,088,967 |
| Greene Barry E | President | 10/02/2017 | 1,821,497 |
| Greene Barry E | President | 10/02/2017 | 10,664,500 |
| Greene Barry E | President | 09/21/2017 | 146,042 |
| Greene Barry E | President | 09/20/2017 | 2,411,223 |
| Greene Barry E | President | 09/20/2017 | 7,681,500 |
| Vaishnaw Akshay | EVP, R&D | 06/13/2017 | 31,953 |
| Vaishnaw Akshay | EVP, R&D | 06/13/2017 | 32,007 |
| Sanofi | 10% Owner | 05/31/2017 | 21,381,398 |
| KEATING LAURIE | SVP, GC and Secretary | 05/30/2017 | 751,502 |
| Vaishnaw Akshay | EVP, R&D | 05/23/2017 | 234,850 |
| Vaishnaw Akshay | EVP, R&D | 05/23/2017 | 825,000 |
| Mason Michael | VP, Finance and Treasurer | 05/16/2017 | 131,587 |
| Mason Michael | VP, Finance and Treasurer | 05/16/2017 | 656,250 |
| Vaishnaw Akshay | SVP, R&D | 05/15/2017 | 1,262,872 |
| Vaishnaw Akshay | SVP, R&D | 05/15/2017 | 2,843,750 |
| SHARP PHILIP A | Director | 02/01/2017 | 782,250 |
| SHARP PHILIP A | Director | 02/01/2017 | 995,125 |
| SHARP PHILIP A | Director | 01/25/2017 | 470,850 |
| SHARP PHILIP A | Director | 01/25/2017 | 569,250 |
| SHARP PHILIP A | Director | 01/18/2017 | 238,650 |
| SHARP PHILIP A | Director | 01/18/2017 | 567,456 |
| MARAGANORE JOHN | Chief Executive Officer | 01/05/2017 | 25,004 |
| Vaishnaw Akshay | EVP, R&D | 12/30/2016 | 187,200 |
| Vaishnaw Akshay | EVP, R&D | 12/30/2016 | 187,251 |
| MARAGANORE JOHN | Chief Executive Officer | 12/12/2016 | 967,673 |
| MARAGANORE JOHN | Chief Executive Officer | 12/12/2016 | 685,935 |
| Greene Barry E | President | 12/01/2016 | 1,265,014 |
| Greene Barry E | President | 12/01/2016 | 1,368,128 |
| Vaishnaw Akshay | EVP, R&D, CMO | 11/30/2016 | 663,504 |
| Vaishnaw Akshay | EVP, R&D, CMO | 11/30/2016 | 1,311,998 |
| PYOTT DAVID E I | Director | 10/13/2016 | 1,032,328 |
| MARAGANORE JOHN | Chief Executive Officer | 10/12/2016 | 99,994 |
| MARAGANORE JOHN | CEO | 07/20/2016 | 342,956 |
| MARAGANORE JOHN | CEO | 07/19/2016 | 342,979 |
| MARAGANORE JOHN | CEO | 07/20/2016 | 988,592 |
| MARAGANORE JOHN | CEO | 07/19/2016 | 961,998 |
| MARAGANORE JOHN | Chief Executive Officer | 04/20/2016 | 342,956 |
| MARAGANORE JOHN | Chief Executive Officer | 04/19/2016 | 342,979 |
| MARAGANORE JOHN | Chief Executive Officer | 04/19/2016 | 1,016,199 |
| MARAGANORE JOHN | Chief Executive Officer | 04/20/2016 | 1,017,773 |
| Greene Barry E | President and COO | 03/24/2016 | 135,672 |
| BONNEY MICHAEL W | Director | 03/09/2016 | 116,720 |
| Gros David-Alexandre C | SVP, Chief Business Officer | 02/22/2016 | 62,749 |
| Sanofi | 10% Owner | 02/01/2016 | 14,300,843 |
| MARAGANORE JOHN | Chief Executive Officer | 01/20/2016 | 342,979 |
| MARAGANORE JOHN | Chief Executive Officer | 01/19/2016 | 342,979 |
| MARAGANORE JOHN | Chief Executive Officer | 01/20/2016 | 1,047,234 |
| MARAGANORE JOHN | Chief Executive Officer | 01/19/2016 | 1,116,985 |
| SHARP PHILIP A | Director | 12/04/2015 | 428,400 |
| SHARP PHILIP A | Director | 12/04/2015 | 3,270,000 |
| MARAGANORE JOHN | Chief Executive Officer | 12/02/2015 | 770,000 |
| MARAGANORE JOHN | Chief Executive Officer | 12/02/2015 | 6,154,716 |
| Vaishnaw Akshay | EVP, R&D, CMO | 11/25/2015 | 99,750 |
| MARAGANORE JOHN | Chief Executive Officer | 11/20/2015 | 845,017 |
| MARAGANORE JOHN | Chief Executive Officer | 11/20/2015 | 6,037,939 |
| STARR KEVIN P | Director | 11/11/2015 | 374,125 |
| STARR KEVIN P | Director | 11/12/2015 | 537,125 |
| STARR KEVIN P | Director | 11/11/2015 | 4,037,036 |
| STARR KEVIN P | Director | 11/12/2015 | 3,755,067 |
| Greene Barry E | President and COO | 08/04/2015 | 505,124 |
| Vaishnaw Akshay | EVP, R&D, CMO | 06/16/2015 | 75,875 |
| Vaishnaw Akshay | EVP, R&D, CMO | 06/16/2015 | 1,127,236 |
| Mason Michael | VP, Finance and Treasurer | 06/01/2015 | 220,526 |
| Mason Michael | VP, Finance and Treasurer | 06/01/2015 | 631,647 |
| Greene Barry E | President and COO | 05/26/2015 | 884,012 |
| Greene Barry E | President and COO | 05/26/2015 | 8,422,375 |
| BONNEY MICHAEL W | Director | 05/12/2015 | 224,320 |
| Ausiello Dennis A | Director | 04/21/2015 | 1,061,613 |
| SCHIMMEL PAUL | Director | 04/21/2015 | 286,850 |
| SCHIMMEL PAUL | Director | 04/21/2015 | 1,300,200 |
| SCHIMMEL PAUL | Director | 03/19/2015 | 246,966 |
| SCHIMMEL PAUL | Director | 03/17/2015 | 25,834 |
| SCHIMMEL PAUL | Director | 03/19/2015 | 1,086,360 |
| SCHIMMEL PAUL | Director | 03/17/2015 | 113,640 |
| Ausiello Dennis A | Director | 03/19/2015 | 600,000 |
| Vaishnaw Akshay | EVP, R&D, CMO | 03/17/2015 | 75,875 |
| Vaishnaw Akshay | EVP, R&D, CMO | 03/17/2015 | 1,022,568 |
| Ausiello Dennis A | Director | 03/05/2015 | 45,085 |
| Ausiello Dennis A | Director | 03/05/2015 | 81,190 |
| Fanucci Marsha | Director | 02/25/2015 | 1,057,953 |
| Sanofi | 10% Owner | 01/29/2015 | 9,226,210 |
| Sanofi | 10% Owner | 01/22/2015 | 18,284,705 |
| MARAGANORE JOHN | Chief Executive Officer | 01/26/2015 | 950,000 |
| PAUL STEVEN M | Director | 01/26/2015 | 95,000 |
| Sanofi | 10% Owner | 01/26/2015 | 61,507,560 |
| Sanofi | 10% Owner | 01/22/2015 | 1,828,470,567 |
| Reid Laurence | SVP, Chief Business Officer | 12/31/2014 | 271,794 |
| Reid Laurence | SVP, Chief Business Officer | 12/31/2014 | 271,830 |
| Greene Barry E | President and COO | 12/22/2014 | 13,120 |
| Greene Barry E | President and COO | 12/19/2014 | 1,120,000 |
| MARAGANORE JOHN | Chief Executive Officer | 12/15/2014 | 74,994 |
| Vaishnaw Akshay | EVP, Chief Medical Officer | 12/16/2014 | 93,022 |
| Vaishnaw Akshay | EVP, Chief Medical Officer | 12/16/2014 | 994,588 |
| Mason Michael | VP, Finance and Treasurer | 12/15/2014 | 237,117 |
| Mason Michael | VP, Finance and Treasurer | 12/15/2014 | 2,160,808 |
| SCHIMMEL PAUL | Director | 12/08/2014 | 331,350 |
| SCHIMMEL PAUL | Director | 12/08/2014 | 1,575,000 |
| Ausiello Dennis A | Director | 12/08/2014 | 451,350 |
| Ausiello Dennis A | Director | 12/08/2014 | 1,625,000 |
| Reid Laurence | SVP, Chief Business Officer | 11/18/2014 | 111,227 |
| Reid Laurence | SVP, Chief Business Officer | 11/18/2014 | 906,670 |
| Greene Barry E | President and COO | 11/17/2014 | 225,096 |
| Greene Barry E | President and COO | 11/17/2014 | 2,975,780 |
| Greene Barry E | President and COO | 11/11/2014 | 75,258 |
| Greene Barry E | President and COO | 11/11/2014 | 1,110,000 |
| Ausiello Dennis A | Director | 11/11/2014 | 150,450 |
| Ausiello Dennis A | Director | 11/11/2014 | 500,000 |
| SCHIMMEL PAUL | Director | 10/28/2014 | 238,650 |
| SCHIMMEL PAUL | Director | 10/28/2014 | 1,425,000 |
| Ausiello Dennis A | Director | 10/22/2014 | 150,450 |
| Ausiello Dennis A | Director | 10/22/2014 | 450,000 |
| SHARP PHILIP A | Director | 10/13/2014 | 847,800 |
| SHARP PHILIP A | Director | 10/13/2014 | 9,350,000 |
| STARR KEVIN P | Director | 09/25/2014 | 988,500 |
| STARR KEVIN P | Director | 09/24/2014 | 527,650 |
| STARR KEVIN P | Director | 09/24/2014 | 3,558,557 |
| STARR KEVIN P | Director | 09/25/2014 | 3,469,881 |
| MARAGANORE JOHN | Chief Executive Officer | 09/18/2014 | 424,550 |
| MARAGANORE JOHN | Chief Executive Officer | 09/17/2014 | 424,550 |
| MARAGANORE JOHN | Chief Executive Officer | 09/18/2014 | 4,481,823 |
| MARAGANORE JOHN | Chief Executive Officer | 09/17/2014 | 4,350,750 |
| Vaishnaw Akshay | EVP, Chief Medical Officer | 09/16/2014 | 93,013 |
| Vaishnaw Akshay | EVP, Chief Medical Officer | 09/16/2014 | 765,463 |
| Reid Laurence | SVP, Chief Business Officer | 08/18/2014 | 118,290 |
| Reid Laurence | SVP, Chief Business Officer | 08/18/2014 | 909,030 |
| MARAGANORE JOHN | Chief Executive Officer | 06/26/2014 | 424,550 |
| MARAGANORE JOHN | Chief Executive Officer | 06/25/2014 | 424,550 |
| MARAGANORE JOHN | Chief Executive Officer | 06/26/2014 | 3,682,926 |
| MARAGANORE JOHN | Chief Executive Officer | 06/25/2014 | 3,757,171 |
| Vaishnaw Akshay | EVP, Chief Medical Officer | 06/17/2014 | 93,013 |
| Vaishnaw Akshay | EVP, Chief Medical Officer | 06/17/2014 | 741,798 |
| CLARKE JOHN K | Director | 05/21/2014 | 456,850 |
| CLARKE JOHN K | Director | 05/21/2014 | 1,882,979 |
| Reid Laurence | SVP, Chief Business Officer | 05/19/2014 | 118,290 |
| Reid Laurence | SVP, Chief Business Officer | 05/19/2014 | 780,684 |
| MARAGANORE JOHN | Chief Executive Officer | 05/15/2014 | 400,973 |
| MARAGANORE JOHN | Chief Executive Officer | 05/14/2014 | 385,335 |
| MARAGANORE JOHN | Chief Executive Officer | 05/15/2014 | 3,188,227 |
| MARAGANORE JOHN | Chief Executive Officer | 05/14/2014 | 3,259,715 |
| MARAGANORE JOHN | CEO | 04/14/2014 | 524,962 |
| Sanofi | 10% Owner | 03/25/2014 | 23,036,681 |
| Vaishnaw Akshay | EVP, Chief Medical Officer | 03/18/2014 | 380,002 |
| Vaishnaw Akshay | EVP, Chief Medical Officer | 03/18/2014 | 2,423,223 |
| Vaishnaw Akshay | EVP, Chief Medical Officer | 02/21/2014 | 235,611 |
| Reid Laurence | SVP, Chief Business Officer | 02/19/2014 | 126,965 |
| Reid Laurence | SVP, Chief Business Officer | 02/19/2014 | 1,633,240 |
| Mason Michael | VP, Finance and Treasurer | 02/03/2014 | 294,992 |
| Greene Barry E | President and COO | 02/03/2014 | 132,182 |
| Greene Barry E | President and COO | 02/03/2014 | 132,210 |
| MARAGANORE JOHN | CEO | 02/03/2014 | 314,124 |
| Mason Michael | VP, Finance and Tresurer | 01/23/2014 | 229,094 |
| Reid Laurence | SVP, Chief Business Officer | 01/23/2014 | 330,934 |
| Vaishnaw Akshay | EVP, Chief Medical Officer | 01/23/2014 | 420,424 |
| Vaishnaw Akshay | EVP, Chief Medical Officer | 01/24/2014 | 676,589 |
| SCHIMMEL PAUL | Director | 01/13/2014 | 237,300 |
| SCHIMMEL PAUL | Director | 01/13/2014 | 1,280,400 |
| Reid Laurence | SVP, Chief Business Officer | 12/30/2013 | 59,994 |
| Reid Laurence | SVP, Chief Business Officer | 12/30/2013 | 59,994 |
| SCHIMMEL PAUL | Director | 12/20/2013 | 169,950 |
| SCHIMMEL PAUL | Director | 12/20/2013 | 975,000 |
| Mason Michael | VP, Finance and Treasurer | 12/16/2013 | 100,510 |
| Mason Michael | VP, Finance and Treasurer | 12/16/2013 | 482,872 |
| Vaishnaw Akshay | EVP, Chief Medical Officer | 12/16/2013 | 127,900 |
| Vaishnaw Akshay | EVP, Chief Medical Officer | 12/17/2013 | 239,501 |
| Vaishnaw Akshay | EVP, Chief Medical Officer | 12/17/2013 | 1,127,761 |
| Vaishnaw Akshay | EVP, Chief Medical Officer | 12/16/2013 | 905,298 |
| Greene Barry E | President and COO | 12/17/2013 | 75,936 |
| Mason Michael | VP, Finance and Treasurer | 12/02/2013 | 26,625 |
| Mason Michael | VP, Finance and Treasurer | 12/02/2013 | 231,863 |
| Reid Laurence | SVP, Chief Business Officer | 11/13/2013 | 215,865 |
| Reid Laurence | SVP, Chief Business Officer | 11/13/2013 | 720,302 |
| SCHIMMEL PAUL | Director | 10/22/2013 | 139,500 |
| SCHIMMEL PAUL | Director | 10/22/2013 | 900,000 |
| MARAGANORE JOHN | Chief Executive Officer | 10/10/2013 | 85,869 |
| MARAGANORE JOHN | Chief Executive Officer | 09/11/2013 | 56,000 |
| MARAGANORE JOHN | Chief Executive Officer | 09/11/2013 | 3,271,524 |
| Vaishnaw Akshay | EVP, Chief Medical Officer | 09/10/2013 | 58,125 |
| Vaishnaw Akshay | EVP, Chief Medical Officer | 09/10/2013 | 359,238 |
| MARAGANORE JOHN | Chief Executive Officer | 08/14/2013 | 57,000 |
| MARAGANORE JOHN | Chief Executive Officer | 08/14/2013 | 2,938,126 |
| Mason Michael | VP, Finance & Treasurer | 07/12/2013 | 445,738 |
| Mason Michael | VP, Finance & Treasurer | 07/12/2013 | 710,000 |
| MARAGANORE JOHN | Chief Executive Officer | 07/10/2013 | 57,000 |
| MARAGANORE JOHN | Chief Executive Officer | 07/10/2013 | 2,226,822 |
| Mason Michael | VP, Finance and Treasurer | 07/01/2013 | 597,450 |
| Mason Michael | VP, Finance and Treasurer | 07/01/2013 | 864,000 |
| Mason Michael | VP, Finance and Treasurer | 06/17/2013 | 322,203 |
| Mason Michael | VP, Finance and Treasurer | 06/17/2013 | 707,160 |
| Vaishnaw Akshay | EVP, Chief Medical Officer | 06/11/2013 | 127,900 |
| Vaishnaw Akshay | EVP, Chief Medical Officer | 06/11/2013 | 466,137 |
| Reid Laurence | SVP and Chief Business Officer | 05/28/2013 | 35,500 |
| Reid Laurence | SVP and Chief Business Officer | 05/28/2013 | 150,000 |
| Greene Barry E | President and COO | 05/28/2013 | 21,681 |
| Greene Barry E | President and COO | 05/28/2013 | 684,660 |
| STARR KEVIN P | Director | 03/26/2013 | 24,700 |
| STARR KEVIN P | Director | 03/25/2013 | 25,299 |
| STARR KEVIN P | Director | 03/26/2013 | 608,577 |
| STARR KEVIN P | Director | 03/25/2013 | 627,557 |
| Greene Barry E | President & COO | 03/14/2013 | 22,855 |
| Greene Barry E | President & COO | 03/14/2013 | 601,450 |
| Vaishnaw Akshay | EVP, Chief Medical Officer | 03/11/2013 | 58,125 |
| Vaishnaw Akshay | EVP, Chief Medical Officer | 03/11/2013 | 153,415 |
| Greene Barry E | President and COO | 03/08/2013 | 22,800 |
| Greene Barry E | President and COO | 03/08/2013 | 586,270 |
| MARAGANORE JOHN | Chief Executive Officer | 02/28/2013 | 669,900 |
| MARAGANORE JOHN | Chief Executive Officer | 02/27/2013 | 704,019 |
| Reid Laurence | SVP, Chief Business Officer | 02/08/2013 | 35,500 |
| Reid Laurence | SVP, Chief Business Officer | 02/08/2013 | 125,000 |
| SHARP PHILIP A | Director | 01/22/2013 | 99,986 |
| MARAGANORE JOHN | CEO | 12/19/2012 | 8,843 |
| Vaishnaw Akshay | EVP, Chief Medical Officer | 12/12/2012 | 92,400 |
| Vaishnaw Akshay | EVP, Chief Medical Officer | 12/10/2012 | 33,917 |
| Vaishnaw Akshay | EVP, Chief Medical Officer | 12/12/2012 | 190,000 |
| Vaishnaw Akshay | EVP, Chief Medical Officer | 12/10/2012 | 81,209 |
| Vaishnaw Akshay | EVP, Chief Medical Officer | 12/04/2012 | 17,040 |
| Vaishnaw Akshay | EVP, Chief Medical Officer | 12/04/2012 | 40,896 |
| Vaishnaw Akshay | EVP, Chief Medical Officer | 11/30/2012 | 20,043 |
| Vaishnaw Akshay | EVP, Chief Medical Officer | 11/30/2012 | 48,072 |
| Mason Michael | VP, Finance and Treasurer | 11/30/2012 | 26,625 |
| Mason Michael | VP, Finance and Treasurer | 11/30/2012 | 63,472 |
| NOVARTIS AG | 10% Owner | 09/20/2012 | 30,137,820 |
| Vaishnaw Akshay | EVP, Chief Medical Officer | 09/10/2012 | 12,406 |
| Vaishnaw Akshay | EVP, Chief Medical Officer | 09/12/2012 | 45,719 |
| Vaishnaw Akshay | EVP, Chief Medical Officer | 09/10/2012 | 25,346 |
| Vaishnaw Akshay | EVP, Chief Medical Officer | 09/12/2012 | 93,404 |
| Mason Michael | VP, Finance and Treasurer | 07/27/2012 | 68,625 |
| Mason Michael | VP, Finance and Treasurer | 07/27/2012 | 125,000 |
| Vaishnaw Akshay | SVP, Chief Medical Officer | 07/16/2012 | 335,325 |
| Vaishnaw Akshay | SVP, Chief Medical Officer | 07/16/2012 | 688,750 |
| Mason Michael | VP, Finance & Treasurer | 07/16/2012 | 174,554 |
| Mason Michael | VP, Finance & Treasurer | 07/16/2012 | 284,043 |
| SHARP PHILIP A | Director | 02/21/2012 | 99,997 |
| SCHIMMEL PAUL | Director | 02/21/2012 | 999,997 |
| Fanucci Marsha | Director | 02/21/2012 | 107,500 |
| Reid Laurence | SVP, Chief Business Officer | 02/21/2012 | 9,998 |
| Greene Barry E | President and COO | 02/21/2012 | 19,995 |
| MARAGANORE JOHN | CEO | 02/21/2012 | 59,996 |
| Greene Barry E | President and COO | 01/09/2012 | 4,992 |
| MARAGANORE JOHN | CEO | 01/09/2012 | 9,995 |
| Greene Barry E | President and COO | 12/12/2011 | 4,995 |
| MARAGANORE JOHN | CEO | 12/12/2011 | 9,995 |
| Greene Barry E | President and COO | 11/14/2011 | 4,994 |
| MARAGANORE JOHN | CEO | 11/14/2011 | 9,997 |
| Greene Barry E | President and COO | 10/11/2011 | 4,996 |
| MARAGANORE JOHN | CEO | 10/11/2011 | 9,989 |
| MARAGANORE JOHN | CEO | 08/17/2010 | 23,750 |
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FUNDS WITH A POSITION IN ALNYLAM PHARMACEUTICALS, INC.
| Fund | # Shares Owned | % of Portfolio | % Change | Investing Style |
|---|---|---|---|---|
| CAPITAL WORLD INVESTORS | 14,971,343 | 0.59% | 17.06% | Growth At A Reasonable Price |
| BLACKROCK INC. | 9,547,663 | 0.05% | 5.79% | Other |
| DODGE & COX | 3,780,185 | 0.55% | -0.82% | Value |
| CAPITAL RESEARCH GLOBAL INVESTORS | 3,255,648 | 0.17% | 3.52% | Growth At A Reasonable Price |
| GEODE CAPITAL MANAGEMENT, LLC | 2,080,275 | 0.04% | 3.92% | Other |
| CANDRIAM S.C.A. | 351,228 | 0.52% | 10.83% | Other |
| BALYASNY ASSET MANAGEMENT L.P. | 287,627 | 0.08% | Exited | Event Driven |
| D. E. SHAW & CO., INC. | 279,398 | 0.06% | 170.24% | Other |
| AQR CAPITAL MANAGEMENT LLC | 271,619 | 0.1% | 92.45% | Other |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 254,000 | 0.11% | New | Other |
| ORBIMED ADVISORS LLC | 250,300 | 1.2% | New | Other |
| PALO ALTO INVESTORS LP | 183,123 | 5.16% | New | Other |
| PALO ALTO INVESTORS LP | 182,766 | 3.08% | Exited | Other |
| DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C) | 119,800 | 0.48% | New | Other |
| D. E. SHAW & CO., INC. | 23,600 (Call) | 0.00536% | -77.8% | Other |
| TUDOR INVESTMENT CORP ET AL | 60,393 | 0.08% | New | Event Driven, Other |
| D. E. SHAW & CO., INC. | 4,600 (Put) | 0.00105% | -89.23% | Other |
| PARNASSUS INVESTMENTS, LLC | 38,748 | 0.01% | Exited | Growth At A Reasonable Price |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 37,624 | 0.34% | 15.2% | Growth At A Reasonable Price |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 32,489 | 0.08% | New | Growth |
| OCONNOR, A DISTINCT BUSINESS UNIT OF UBS ASSET MANAGEMENT AMERICAS (LLC) | 19,100 (Put) | 0.00174% | New | Value |
| MELQART ASSET MANAGEMENT (UK) LTD | 13,500 (Call) | 0.27% | New | Event Driven |
| MELQART ASSET MANAGEMENT (UK) LTD | 13,500 (Put) | 0.27% | New | Event Driven |
| GOTHAM ASSET MANAGEMENT, LLC | 13,237 | 0.04% | 546.65% | Other |
| OCONNOR, A DISTINCT BUSINESS UNIT OF UBS ASSET MANAGEMENT AMERICAS (LLC) | 10,000 (Call) | 0.00286% | New | Value |
| FARALLON CAPITAL MANAGEMENT LLC | 2,000 | 0.00136% | Exited | Event Driven, Value |
| MOTLEY FOOL ASSET MANAGEMENT LLC | 1,890 | 0.03% | -3.57% | Growth At A Reasonable Price |
CHANGE IN SHARES OUTSTANDING FOR ALNYLAM PHARMACEUTICALS, INC.
STOCK BUYBACKS FOR ALNYLAM PHARMACEUTICALS, INC.
Period of Report
Previous Period
% Change in Shares
10-K/10-Q Filings
Quarter
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Period of Report: 06/30/2024
10-K/10-Q Filings: View
Previous Period
% Change in Shares
Quarter
03/31/2024
0.47%
1Q
12/31/2023
0.88%
2Q
09/30/2023
-3.51%
3Q
06/30/2023
1.66%
4Q
03/31/2023
2.11%
5Q
12/31/2022
2.80%
6Q
09/30/2022
3.74%
7Q
06/30/2022
4.83%
8Q
03/31/2022
5.27%
9Q
12/31/2021
5.80%
10Q
09/30/2021
6.37%
11Q
06/30/2021
7.61%
12Q
03/31/2021
8.24%
13Q
12/31/2020
8.99%
14Q
09/30/2020
9.27%
15Q
06/30/2020
10.29%
16Q
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BUYBACK ANNOUNCEMENT(S) FOR ALNYLAM PHARMACEUTICALS, INC.
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