. (AEGR)

$1.97 0 (0.00%)

Market Cap: $0

As of 01/13/17 12:00 AM EST. Market closed.

(AEGR)

. (AEGR)

$1.97 0 (0.00%)

Market Cap: $0

As of 01/13/17 12:00 AM EST. Market closed.

COMPANY PROFILE
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Industry
URL
Address
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Sector
Industry
URL
Address
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PRICE CHART
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1m
3m
6m
YTD
1y
5y
MAX
From: To:
NEWS
KEY STATS
Open
$0
Previous Close
$1.97
Days Range
$0 - $0
52 week range
$0 - $0
Volume
0
Avg. Volume (30 days)
0
Market Cap
$0
Dividend Yield
0.00%
P/E
-
Shares Outstanding
0
Open
$0
Previous Close
$1.97
Days Range
$0 - $0
52 week range
$0 - $0
Volume
0
Avg. Volume (30 days)
0
Market Cap
$0
Dividend Yield
0.00%
P/E
-
Shares Outstanding
0

Open in: SeekingAlpha Yahoo Finance Fidelity MorningStar

Open in: SeekingAlpha Yahoo Finance Fidelity MorningStar

INSIDER TRANSACTIONS FOR
Owner Relationship Date Transaction Cost # Shares Value($) Total Shares Form 4
Harshbarger Benjamin General Counsel Sep 17, 2016 Option Exercise $1.78 532 947 1,704 Sep 20, 2016, 04:03 PM
Harshbarger Benjamin General Counsel Apr 01, 2016 Option Exercise $3.55 273 969 594 Sep 20, 2016, 04:03 PM
Broadfin Healthcare Master Fund Ltd 10% Owner Sep 13, 2016 Buy $1.75 75,000 131,250 4,361,291 Sep 14, 2016, 04:16 PM
Broadfin Healthcare Master Fund Ltd 10% Owner Sep 12, 2016 Buy $1.70 176,000 298,800 4,286,291 Sep 12, 2016, 06:44 PM
Broadfin Healthcare Master Fund Ltd 10% Owner Sep 09, 2016 Buy $1.60 100,000 159,500 4,110,291 Sep 12, 2016, 06:44 PM
SMITH SANDFORD D Director Jul 27, 2016 Option Exercise $1.55 777 1,204 2,890 Jul 29, 2016, 04:01 PM
Broadfin Healthcare Master Fund Ltd 10% Owner Mar 18, 2016 Option Exercise $7.50 497,600 3,732,000 4,010,291 Mar 21, 2016, 04:48 PM
Broadfin Healthcare Master Fund Ltd 10% Owner Mar 17, 2016 Option Exercise $7.50 2,400 18,000 3,512,691 Mar 21, 2016, 04:48 PM
SMITH SANDFORD D Director Jan 27, 2016 Option Exercise $6.78 778 5,275 1,445 Jan 29, 2016, 06:05 AM
Broadfin Healthcare Master Fund Ltd 10% Owner Nov 11, 2015 Buy $10.96 40,100 439,649 4,010,291 Nov 13, 2015, 03:24 PM
Fitzpatrick Mark J. Chief Financial Officer Aug 19, 2014 Buy $30.64 1,150 35,236 9,500 Aug 20, 2014, 09:36 AM
Beer Marc D Chief Executive Officer Jul 31, 2014 Buy $33.65 10,000 336,539 79,400 Jul 31, 2014, 12:30 PM
Beer Marc D Chief Executive Officer Jun 03, 2014 Buy $30.12 10,000 301,200 69,400 Jun 04, 2014, 09:30 AM
Beer Marc D Chief Executive Officer May 27, 2014 Buy $31.59 10,000 315,900 59,400 May 27, 2014, 12:57 PM
Beer Marc D Chief Executive Officer May 21, 2014 Option Exercise $1.54 6,400 9,856 49,400 May 22, 2014, 09:39 AM
Beer Marc D Chief Executive Officer May 20, 2014 Buy $30.53 10,000 305,300 43,000 May 21, 2014, 09:40 AM
VANLENT ANNE Director May 08, 2014 Buy $33.78 4,000 135,110 4,000 May 09, 2014, 09:24 AM
Beer Marc D Chief Executive Officer May 08, 2014 Buy $35.31 30,000 1,059,300 33,000 May 08, 2014, 10:20 AM
Fraser Craig Pres., US/Int. Comm. & Manuf. Mar 31, 2014 Option Exercise $13.01 2,250 29,273 2,250 Apr 02, 2014, 04:01 PM
Fraser Craig Pres., US/Int. Comm. & Manuf. Mar 31, 2014 Sale $46.20 2,250 103,947 1,101 Apr 02, 2014, 04:01 PM
Beer Marc D Chief Executive Officer Mar 26, 2014 Option Exercise $1.54 3,000 4,620 3,000 Mar 27, 2014, 05:26 PM
Sumeray Mark Chief Medical Officer Mar 14, 2014 Option Exercise $13.01 2,000 26,020 2,000 Mar 18, 2014, 04:01 PM
Sumeray Mark Chief Medical Officer Mar 14, 2014 Sale $51.34 2,000 102,670 1,700 Mar 18, 2014, 04:01 PM
Fitzpatrick Mark J. Chief Financial Officer Mar 04, 2014 Option Exercise $17.64 2,500 44,100 8,350 Mar 05, 2014, 06:46 PM
Sumeray Mark Chief Medical Officer Feb 14, 2014 Option Exercise $13.01 2,000 26,020 2,000 Feb 18, 2014, 04:05 PM
Sumeray Mark Chief Medical Officer Feb 14, 2014 Sale $63.48 2,000 126,970 500 Feb 18, 2014, 04:05 PM
Fitzpatrick Mark J. Chief Financial Officer Feb 10, 2014 Option Exercise $17.64 7,500 132,300 13,350 Feb 12, 2014, 04:01 PM
Fraser Craig Pres., US/Int. Comm. & Manuf. Feb 11, 2014 Option Exercise $13.01 2,250 29,273 2,250 Feb 12, 2014, 04:01 PM
Fraser Craig Pres., US/Int. Comm. & Manuf. Feb 11, 2014 Sale $67.00 2,250 150,750 0 Feb 12, 2014, 04:01 PM
Fitzpatrick Mark J. Chief Financial Officer Feb 10, 2014 Sale $62.61 7,500 469,543 10,050 Feb 12, 2014, 04:01 PM
Sumeray Mark Chief Medical Officer Jan 16, 2014 Option Exercise $13.01 2,000 26,020 2,000 Jan 21, 2014, 04:01 PM
Sumeray Mark Chief Medical Officer Jan 16, 2014 Sale $58.63 2,000 117,269 100 Jan 21, 2014, 04:01 PM
Fraser Craig Pres., US/Int. Comm. & Manuf. Jan 02, 2014 Option Exercise $13.01 2,250 29,273 2,250 Jan 06, 2014, 04:02 PM
Fraser Craig Pres., US/Int. Comm. & Manuf. Jan 02, 2014 Sale $71.11 2,250 159,998 1,350 Jan 06, 2014, 04:02 PM
Sumeray Mark Chief Medical Officer Jan 02, 2014 Option Exercise $13.01 1,000 13,010 1,000 Jan 06, 2014, 04:01 PM
Sumeray Mark Chief Medical Officer Jan 02, 2014 Sale $70.93 1,000 70,934 600 Jan 06, 2014, 04:01 PM
Sumeray Mark Chief Medical Officer Dec 16, 2013 Option Exercise $13.01 2,000 26,020 2,000 Dec 17, 2013, 04:06 PM
Sumeray Mark Chief Medical Officer Dec 16, 2013 Sale $66.34 2,000 132,687 200 Dec 17, 2013, 04:06 PM
Beer Marc D Chief Executive Officer Dec 04, 2013 Option Exercise $1.54 4,380 6,745 4,380 Dec 06, 2013, 07:24 AM
Sumeray Mark Chief Medical Officer Dec 02, 2013 Option Exercise $13.01 3,000 39,030 3,000 Dec 04, 2013, 05:01 PM
Sumeray Mark Chief Medical Officer Dec 02, 2013 Sale $70.42 3,000 211,267 600 Dec 04, 2013, 05:01 PM
Fraser Craig Pres., US/Int. Comm. & Manuf. Dec 02, 2013 Option Exercise $13.01 2,250 29,273 2,250 Dec 04, 2013, 05:00 PM
Fraser Craig Pres., US/Int. Comm. & Manuf. Dec 02, 2013 Sale $70.41 2,250 158,423 700 Dec 04, 2013, 05:00 PM
Sumeray Mark Chief Medical Officer Nov 15, 2013 Option Exercise $13.01 2,000 26,020 2,000 Nov 19, 2013, 05:00 PM
Sumeray Mark Chief Medical Officer Nov 15, 2013 Sale $76.09 2,000 152,182 1,511 Nov 19, 2013, 05:00 PM
Fitzpatrick Mark J. Chief Financial Officer Nov 11, 2013 Option Exercise $17.64 10,350 182,574 10,500 Nov 13, 2013, 05:31 PM
Fitzpatrick Mark J. Chief Financial Officer Nov 11, 2013 Sale $79.04 7,500 592,829 10,300 Nov 13, 2013, 05:31 PM
Beer Marc D Chief Executive Officer Nov 05, 2013 Option Exercise $1.54 39,000 60,060 234,726 Nov 06, 2013, 05:05 PM
Carter Martha J. Chief Regulatory Officer & SVP Nov 01, 2013 Option Exercise $14.84 5,000 74,200 6,500 Nov 05, 2013, 04:01 PM
Carter Martha J. Chief Regulatory Officer & SVP Nov 01, 2013 Sale $82.81 5,000 414,050 1,500 Nov 05, 2013, 04:01 PM
Sumeray Mark Chief Medical Officer Nov 01, 2013 Option Exercise $13.01 3,500 45,535 3,500 Nov 05, 2013, 04:00 PM
Sumeray Mark Chief Medical Officer Nov 01, 2013 Sale $83.28 3,500 291,481 2,100 Nov 05, 2013, 04:00 PM
Fraser Craig Pres., US/Int. Comm. & Manuf. Nov 01, 2013 Option Exercise $13.01 2,250 29,273 2,250 Nov 05, 2013, 04:00 PM
Fraser Craig Pres., US/Int. Comm. & Manuf. Nov 01, 2013 Sale $83.23 2,250 187,275 1,950 Nov 05, 2013, 04:00 PM
Beer Marc D Chief Executive Officer Oct 30, 2013 Option Exercise $1.54 40,000 61,600 235,726 Oct 31, 2013, 08:35 AM
Beer Marc D Chief Executive Officer Oct 30, 2013 Sale $87.79 40,000 3,511,665 232,926 Oct 31, 2013, 08:35 AM
SMITH SANDFORD D Director Oct 29, 2013 Option Exercise $15.00 2,502 37,530 2,502 Oct 31, 2013, 08:32 AM
SMITH SANDFORD D Director Oct 29, 2013 Sale $95.00 2,502 237,690 0 Oct 31, 2013, 08:32 AM
Sumeray Mark Chief Medical Officer Oct 15, 2013 Option Exercise $13.01 2,000 26,020 2,000 Oct 16, 2013, 05:04 PM
Sumeray Mark Chief Medical Officer Oct 15, 2013 Sale $80.33 2,000 160,659 1,000 Oct 16, 2013, 05:04 PM
Sumeray Mark Chief Medical Officer Oct 07, 2013 Option Exercise $13.01 3,500 45,535 3,500 Oct 08, 2013, 05:15 PM
Sumeray Mark Chief Medical Officer Oct 07, 2013 Sale $93.17 3,500 326,086 1,965 Oct 08, 2013, 05:15 PM
Fraser Craig Pres., US/Int. Comm. & Manuf. Oct 07, 2013 Option Exercise $13.01 20,000 260,200 20,000 Oct 08, 2013, 04:58 PM
Fraser Craig Pres., US/Int. Comm. & Manuf. Oct 07, 2013 Sale $93.16 20,000 1,863,146 10,992 Oct 08, 2013, 04:58 PM
Sumeray Mark Chief Medical Officer Sep 16, 2013 Option Exercise $13.01 2,000 26,020 2,000 Sep 18, 2013, 04:05 PM
Sumeray Mark Chief Medical Officer Sep 16, 2013 Sale $89.77 2,000 179,549 1,400 Sep 18, 2013, 04:05 PM
PERCEPTIVE ADVISORS LLC 10% Owner Sep 05, 2013 Sale $89.20 750,000 66,899,998 2,873,426 Sep 09, 2013, 06:15 PM
PERCEPTIVE ADVISORS LLC 10% Owner Jun 15, 2013 Option Exercise $25.00 200,000 5,000,000 3,573,426 Sep 09, 2013, 06:15 PM
Fitzpatrick Mark J. Chief Financial Officer Aug 26, 2013 Option Exercise $17.64 2,500 44,100 3,000 Aug 28, 2013, 04:30 PM
Scheer David Director Aug 21, 2013 Sale $84.58 20,000 1,691,638 620,554 Aug 23, 2013, 08:00 AM
Sumeray Mark Chief Medical Officer Aug 16, 2013 Option Exercise $13.01 2,000 26,020 2,000 Aug 20, 2013, 05:06 PM
Sumeray Mark Chief Medical Officer Aug 16, 2013 Sale $88.71 2,000 177,413 1,100 Aug 20, 2013, 05:06 PM
Fitzpatrick Mark J. Chief Financial Officer Aug 14, 2013 Option Exercise $17.64 7,500 132,300 8,000 Aug 16, 2013, 04:56 PM
Fitzpatrick Mark J. Chief Financial Officer Aug 14, 2013 Sale $93.44 7,500 700,816 5,488 Aug 16, 2013, 04:56 PM
Beer Marc D Chief Executive Officer Aug 15, 2013 Option Exercise $1.54 60,000 92,400 259,061 Aug 16, 2013, 04:56 PM
Beer Marc D Chief Executive Officer Aug 15, 2013 Sale $88.54 60,000 5,312,209 238,897 Aug 16, 2013, 04:56 PM
SMITH SANDFORD D Director Aug 09, 2013 Option Exercise $16.05 10,000 160,518 10,000 Aug 13, 2013, 04:00 PM
SMITH SANDFORD D Director Aug 09, 2013 Sale $92.33 8,463 781,414 1,537 Aug 13, 2013, 04:00 PM
SMITH SANDFORD D Director Aug 12, 2013 Sale $92.25 1,537 141,791 0 Aug 13, 2013, 04:00 PM
Sumeray Mark Chief Medical Officer Jul 15, 2013 Option Exercise $13.01 2,000 26,020 2,000 Jul 16, 2013, 05:00 PM
Sumeray Mark Chief Medical Officer Jul 15, 2013 Sale $78.77 2,000 157,546 1,500 Jul 16, 2013, 05:00 PM
Sumeray Mark Chief Medical Officer Jun 17, 2013 Option Exercise $13.01 6,000 78,060 6,000 Jun 19, 2013, 04:00 PM
Sumeray Mark Chief Medical Officer Jun 17, 2013 Sale $65.27 6,000 391,620 4,191 Jun 19, 2013, 04:00 PM
Sumeray Mark Chief Medical Officer May 15, 2013 Option Exercise $13.01 6,000 78,060 6,000 May 17, 2013, 04:30 PM
Sumeray Mark Chief Medical Officer May 15, 2013 Sale $47.32 6,000 283,930 0 May 17, 2013, 04:30 PM
Sumeray Mark Chief Medical Officer Apr 22, 2013 Option Exercise $13.01 6,000 78,060 6,000 Apr 24, 2013, 02:23 PM
Sumeray Mark Chief Medical Officer Apr 22, 2013 Sale $40.74 6,000 244,451 2,150 Apr 24, 2013, 02:23 PM
PERCEPTIVE ADVISORS LLC 10% Owner Feb 01, 2013 Buy $27.79 50,000 1,389,400 3,373,426 Feb 05, 2013, 03:54 PM
Carter Martha J. Chief Regulatory Officer & SVP Jan 23, 2013 Buy $27.81 500 13,905 1,500 Jan 24, 2013, 05:12 PM
PERCEPTIVE ADVISORS LLC 10% Owner Jan 18, 2013 Buy $27.62 50,000 1,381,000 3,323,426 Jan 22, 2013, 01:16 PM
PERCEPTIVE ADVISORS LLC 10% Owner Jan 17, 2013 Buy $26.73 50,000 1,336,285 3,273,426 Jan 18, 2013, 01:57 PM
PERCEPTIVE ADVISORS LLC 10% Owner Jan 11, 2013 Buy $27.07 475,000 12,857,220 3,223,426 Jan 15, 2013, 06:07 PM
PERCEPTIVE ADVISORS LLC 10% Owner Dec 04, 2012 Buy $21.27 20,000 425,400 2,615,293 Dec 05, 2012, 01:05 PM
PERCEPTIVE ADVISORS LLC 10% Owner Nov 29, 2012 Buy $22.71 30,000 681,300 2,595,293 Dec 03, 2012, 02:29 PM
PERCEPTIVE ADVISORS LLC 10% Owner Nov 07, 2012 Buy $21.12 30,000 633,600 2,445,293 Dec 03, 2012, 10:36 AM
PERCEPTIVE ADVISORS LLC 10% Owner Nov 28, 2012 Buy $21.76 70,000 1,523,200 2,565,293 Dec 03, 2012, 10:36 AM
PERCEPTIVE ADVISORS LLC 10% Owner Nov 21, 2012 Buy $20.75 20,000 415,000 2,495,293 Dec 03, 2012, 10:36 AM
PERCEPTIVE ADVISORS LLC 10% Owner Nov 20, 2012 Buy $21.01 20,000 420,200 2,475,293 Dec 03, 2012, 10:36 AM
PERCEPTIVE ADVISORS LLC 10% Owner Nov 15, 2012 Buy $19.50 10,000 195,000 2,455,293 Dec 03, 2012, 10:36 AM
PERCEPTIVE ADVISORS LLC 10% Owner Oct 19, 2012 Option Exercise $17.50 247,500 4,331,250 2,347,233 Dec 03, 2012, 10:34 AM
ALTA BIOPHARMA PARTNERS III LP 10% Owner Oct 15, 2012 Sale $17.54 55,626 975,680 2,408,426 Oct 17, 2012, 06:35 PM
ALTA BIOPHARMA PARTNERS III LP 10% Owner Oct 16, 2012 Sale $18.67 11,771 219,765 153,131 Oct 17, 2012, 06:35 PM
ALTA BIOPHARMA PARTNERS III LP 10% Owner Oct 15, 2012 Sale $17.54 5,107 89,577 161,742 Oct 17, 2012, 06:35 PM
ALTA BIOPHARMA PARTNERS III LP 10% Owner Oct 16, 2012 Sale $18.67 128,229 2,394,035 2,280,197 Oct 17, 2012, 06:35 PM
Carter Martha J. Chief Regulatory Officer Mar 30, 2012 Buy $14.03 1,000 14,030 1,000 Apr 02, 2012, 01:10 PM
Beer Marc D Chief Executive Officer Mar 29, 2012 Buy $13.74 1,000 13,735 199,061 Mar 30, 2012, 09:19 AM
Fitzpatrick Mark J. Chief Financial Officer Mar 23, 2012 Buy $14.15 500 7,076 500 Mar 26, 2012, 09:27 AM
Beer Marc D Chief Executive Officer Mar 22, 2012 Buy $13.96 1,000 13,964 198,061 Mar 23, 2012, 10:02 AM
ADVENT INTERNATIONAL CORP/MA Member of Group > 10% Mar 09, 2012 Sale $15.87 100,000 1,586,830 2,457,879 Mar 14, 2012, 03:29 PM
ADVENT INTERNATIONAL LLC Member of Group > 10% Mar 09, 2012 Sale $15.87 98,897 1,569,327 2,430,765 Mar 14, 2012, 03:19 PM
ADVENT HEALTHCARE & LIFE SCIENCES III LIMITED PARTNERSHIP Member of Group > 10% Mar 09, 2012 Sale $15.87 40,077 635,954 985,052 Mar 14, 2012, 03:16 PM
Advent Healthcare & Life Sciences III-A Limited Partnership Member of Group > 10% Mar 09, 2012 Sale $15.87 58,820 933,373 1,445,713 Mar 14, 2012, 03:09 PM
AHLS III GP LIMITED PARTNERSHIP Member of Group > 10% Mar 09, 2012 Sale $15.87 98,897 1,569,327 2,430,765 Mar 14, 2012, 03:08 PM
Advent Partners HLS III Limited Partnership Member of Group > 10% Mar 09, 2012 Sale $15.87 1,103 17,503 27,114 Mar 14, 2012, 03:04 PM
Index Venture Associates III Ltd 10% Owner Jan 30, 2012 Sale $17.08 50,000 854,000 2,081,827 Feb 01, 2012, 08:18 PM
AHLS III GP LIMITED PARTNERSHIP Member of Group > 10% Jan 31, 2012 Sale $17.10 22,054 377,156 2,529,662 Jan 31, 2012, 06:02 PM
AHLS III GP LIMITED PARTNERSHIP Member of Group > 10% Jan 30, 2012 Sale $17.06 2,670 45,563 2,551,716 Jan 31, 2012, 06:02 PM
AHLS III GP LIMITED PARTNERSHIP Member of Group > 10% Jan 27, 2012 Sale $17.17 49,448 848,800 2,554,386 Jan 31, 2012, 06:02 PM
Advent Partners HLS III Limited Partnership Member of Group > 10% Jan 30, 2012 Sale $17.06 30 512 28,463 Jan 31, 2012, 06:01 PM
Advent Partners HLS III Limited Partnership Member of Group > 10% Jan 27, 2012 Sale $17.17 552 9,475 28,493 Jan 31, 2012, 06:01 PM
Advent Partners HLS III Limited Partnership Member of Group > 10% Jan 31, 2012 Sale $17.10 246 4,207 28,217 Jan 31, 2012, 06:01 PM
ADVENT INTERNATIONAL LLC Member of Group > 10% Jan 31, 2012 Sale $17.10 22,054 377,156 2,529,662 Jan 31, 2012, 06:00 PM
ADVENT INTERNATIONAL LLC Member of Group > 10% Jan 30, 2012 Sale $17.06 2,670 45,563 2,551,716 Jan 31, 2012, 06:00 PM
ADVENT INTERNATIONAL LLC Member of Group > 10% Jan 27, 2012 Sale $17.17 49,448 848,800 2,554,386 Jan 31, 2012, 06:00 PM
ADVENT INTERNATIONAL CORP/MA Member of Group > 10% Jan 30, 2012 Sale $17.06 2,700 46,075 2,580,179 Jan 31, 2012, 05:59 PM
ADVENT INTERNATIONAL CORP/MA Member of Group > 10% Jan 27, 2012 Sale $17.17 50,000 858,275 2,582,879 Jan 31, 2012, 05:59 PM
ADVENT INTERNATIONAL CORP/MA Member of Group > 10% Jan 31, 2012 Sale $17.10 22,300 381,363 2,557,879 Jan 31, 2012, 05:59 PM
Advent Healthcare & Life Sciences III-A Limited Partnership Member of Group > 10% Jan 31, 2012 Sale $17.10 13,117 224,320 1,504,533 Jan 31, 2012, 05:55 PM
Advent Healthcare & Life Sciences III-A Limited Partnership Member of Group > 10% Jan 30, 2012 Sale $17.06 1,588 27,099 1,517,650 Jan 31, 2012, 05:55 PM
Advent Healthcare & Life Sciences III-A Limited Partnership Member of Group > 10% Jan 27, 2012 Sale $17.17 29,409 504,820 1,519,238 Jan 31, 2012, 05:55 PM
ADVENT HEALTHCARE & LIFE SCIENCES III LIMITED PARTNERSHIP Member of Group > 10% Jan 31, 2012 Sale $17.10 8,937 152,836 1,025,129 Jan 31, 2012, 05:53 PM
ADVENT HEALTHCARE & LIFE SCIENCES III LIMITED PARTNERSHIP Member of Group > 10% Jan 30, 2012 Sale $17.06 1,082 18,464 1,034,066 Jan 31, 2012, 05:53 PM
ADVENT HEALTHCARE & LIFE SCIENCES III LIMITED PARTNERSHIP Member of Group > 10% Jan 27, 2012 Sale $17.17 20,039 343,979 1,035,148 Jan 31, 2012, 05:53 PM
Advent Partners HLS III Limited Partnership Member of Group > 10% Dec 09, 2011 Sale $16.89 196 3,311 29,045 Dec 09, 2011, 05:32 PM
Advent Partners HLS III Limited Partnership Member of Group > 10% Dec 08, 2011 Sale $16.90 28 473 29,241 Dec 09, 2011, 05:32 PM
Advent Healthcare & Life Sciences III-A Limited Partnership Dec 08, 2011 Sale $16.90 1,470 24,836 1,559,095 Dec 09, 2011, 05:31 PM
Advent Healthcare & Life Sciences III-A Limited Partnership Dec 09, 2011 Sale $16.89 10,448 176,473 1,548,647 Dec 09, 2011, 05:31 PM
ADVENT HEALTHCARE & LIFE SCIENCES III LIMITED PARTNERSHIP Dec 09, 2011 Sale $16.89 7,119 120,244 1,055,187 Dec 09, 2011, 05:30 PM
ADVENT HEALTHCARE & LIFE SCIENCES III LIMITED PARTNERSHIP Dec 08, 2011 Sale $16.90 1,002 16,929 1,062,306 Dec 09, 2011, 05:30 PM
AHLS III GP LIMITED PARTNERSHIP Dec 09, 2011 Sale $16.89 17,567 296,717 2,603,834 Dec 09, 2011, 05:30 PM
AHLS III GP LIMITED PARTNERSHIP Dec 08, 2011 Sale $16.90 2,472 41,765 2,621,401 Dec 09, 2011, 05:30 PM
ADVENT INTERNATIONAL LLC Dec 09, 2011 Sale $16.89 17,567 296,717 2,603,834 Dec 09, 2011, 05:29 PM
ADVENT INTERNATIONAL LLC Dec 08, 2011 Sale $16.90 2,472 41,765 2,621,401 Dec 09, 2011, 05:29 PM
ADVENT INTERNATIONAL CORP/MA Member of Group > 10% Dec 09, 2011 Sale $16.89 17,763 300,028 2,632,879 Dec 09, 2011, 05:28 PM
ADVENT INTERNATIONAL CORP/MA Member of Group > 10% Dec 08, 2011 Sale $16.90 2,500 42,238 2,650,642 Dec 09, 2011, 05:28 PM
Advent Partners HLS III Limited Partnership Member of Group > 10% Dec 06, 2011 Sale $16.96 61 1,034 29,269 Dec 08, 2011, 05:06 PM
Advent Healthcare & Life Sciences III-A Limited Partnership Member of Group > 10% Dec 06, 2011 Sale $16.96 3,274 55,520 1,560,565 Dec 08, 2011, 05:06 PM
ADVENT HEALTHCARE & LIFE SCIENCES III LIMITED PARTNERSHIP Member of Group > 10% Dec 06, 2011 Sale $16.96 2,230 37,816 1,063,308 Dec 08, 2011, 05:05 PM
AHLS III GP LIMITED PARTNERSHIP Member of Group > 10% Dec 06, 2011 Sale $16.96 5,504 93,337 2,623,873 Dec 08, 2011, 05:03 PM
ADVENT INTERNATIONAL LLC Member of Group > 10% Dec 06, 2011 Sale $16.96 5,504 93,337 2,623,873 Dec 08, 2011, 05:02 PM
ADVENT INTERNATIONAL CORP/MA Member of Group > 10% Dec 06, 2011 Sale $16.96 5,565 94,371 2,653,142 Dec 08, 2011, 05:01 PM
Beer Marc D Chief Executive Officer Sep 01, 2011 Buy $14.76 1,484 21,904 7,156 Sep 06, 2011, 01:59 PM
Beer Marc D Chief Executive Officer Sep 01, 2011 Buy $14.75 5,270 77,733 197,061 Sep 06, 2011, 01:59 PM
Beer Marc D Chief Executive Officer Aug 09, 2011 Buy $11.96 8,265 98,849 131,347 Aug 10, 2011, 09:42 AM
Beer Marc D Chief Executive Officer Aug 09, 2011 Buy $11.91 1,800 21,438 133,147 Aug 10, 2011, 09:42 AM
Kiley Alison Director Aug 09, 2011 Buy $12.45 5,500 68,497 2,690,251 Aug 09, 2011, 05:40 PM
Kiley Alison Director Aug 08, 2011 Buy $12.43 4,200 52,204 2,684,751 Aug 09, 2011, 05:40 PM
ALTA BIOPHARMA PARTNERS III LP 10% Owner Aug 09, 2011 Buy $12.45 5,500 68,497 2,464,052 Aug 09, 2011, 05:37 PM
ALTA BIOPHARMA PARTNERS III LP 10% Owner Aug 08, 2011 Buy $12.43 4,200 52,204 2,459,014 Aug 09, 2011, 05:37 PM
Beer Marc D Chief Executive Officer Aug 01, 2011 Buy $15.74 1,392 21,910 123,082 Aug 03, 2011, 02:30 PM
Beer Marc D Chief Executive Officer Aug 01, 2011 Buy $15.74 4,938 77,724 121,690 Aug 03, 2011, 02:30 PM
Index Venture Associates III Ltd 10% Owner Jul 29, 2011 Sale $14.61 36,788 537,425 2,131,827 Aug 02, 2011, 12:12 PM
Ollier Michele Director Jul 29, 2011 Sale $14.61 36,788 537,425 2,131,827 Aug 02, 2011, 12:02 PM
Advent Partners HLS III Limited Partnership Member of Group > 10% Jul 29, 2011 Sale $14.61 57 833 29,330 Jul 29, 2011, 04:40 PM
Advent Healthcare & Life Sciences III-A Limited Partnership Member of Group > 10% Jul 29, 2011 Sale $14.61 3,015 44,045 1,563,839 Jul 29, 2011, 04:39 PM
ADVENT HEALTHCARE & LIFE SCIENCES III LIMITED PARTNERSHIP Member of Group > 10% Jul 29, 2011 Sale $14.61 2,054 30,006 1,065,538 Jul 29, 2011, 04:38 PM
AHLS III GP LIMITED PARTNERSHIP Member of Group > 10% Jul 29, 2011 Sale $14.61 5,069 74,051 2,629,377 Jul 29, 2011, 04:38 PM
ADVENT INTERNATIONAL LLC Member of Group > 10% Jul 29, 2011 Sale $14.61 5,069 74,051 2,629,377 Jul 29, 2011, 04:36 PM
ADVENT INTERNATIONAL CORP/MA Member of Group > 10% Jul 29, 2011 Sale $14.61 5,126 74,884 2,658,707 Jul 29, 2011, 04:35 PM
Index Venture Associates III Ltd 10% Owner Jun 29, 2011 Sale $14.61 877,723 12,822,392 2,168,435 Jul 01, 2011, 02:38 PM
Ollier Michele Director Jun 29, 2011 Sale $14.61 877,723 12,822,392 2,168,435 Jul 01, 2011, 02:25 PM
Advent Partners HLS III Limited Partnership Member of Group > 10% Jun 29, 2011 Sale $14.61 1,349 19,707 29,387 Jun 29, 2011, 04:48 PM
Advent Healthcare & Life Sciences III-A Limited Partnership Member of Group > 10% Jun 29, 2011 Sale $14.61 71,923 1,050,702 1,566,854 Jun 29, 2011, 04:47 PM
ADVENT HEALTHCARE & LIFE SCIENCES III LIMITED PARTNERSHIP Member of Group > 10% Jun 29, 2011 Sale $14.61 49,005 715,899 1,067,592 Jun 29, 2011, 04:46 PM
AHLS III GP LIMITED PARTNERSHIP Member of Group > 10% Jun 29, 2011 Sale $14.61 120,928 1,766,601 2,634,446 Jun 29, 2011, 04:44 PM
ADVENT INTERNATIONAL LLC Member of Group > 10% Jun 29, 2011 Sale $14.61 120,928 1,766,601 2,634,446 Jun 29, 2011, 04:43 PM
ADVENT INTERNATIONAL CORP/MA Member of Group > 10% Jun 29, 2011 Sale $14.61 122,277 1,786,308 2,663,833 Jun 29, 2011, 04:42 PM
Beer Marc D Chief Executive Officer Jun 29, 2011 Buy $15.50 64,516 999,998 181,268 Jun 29, 2011, 02:54 PM
Beer Marc D Chief Executive Officer Jun 01, 2011 Buy $18.73 1,170 21,914 116,752 Jun 03, 2011, 09:00 AM
Beer Marc D Chief Executive Officer Jun 01, 2011 Buy $18.69 4,162 77,788 115,582 Jun 03, 2011, 09:00 AM
Beer Marc D Chief Executive Officer Apr 04, 2011 Buy $16.73 1,310 21,916 111,420 Apr 05, 2011, 05:00 PM
Beer Marc D Chief Executive Officer Apr 04, 2011 Buy $16.73 4,647 77,744 110,110 Apr 05, 2011, 05:00 PM
Scheer David Director Mar 10, 2011 Buy $15.11 3,994 60,349 644,148 Mar 14, 2011, 12:25 PM
Scheer David Director Mar 11, 2011 Buy $15.36 6,006 92,252 650,154 Mar 14, 2011, 12:25 PM
Beer Marc D Chief Executive Officer Dec 15, 2010 Buy $12.33 200 2,465 105,463 Dec 17, 2010, 05:27 PM
Kiley Alison Director Oct 27, 2010 Buy $9.50 315,789 2,999,996 2,680,551 Nov 10, 2010, 03:47 PM
ALTA BIOPHARMA PARTNERS III LP 10% Owner Oct 27, 2010 Option Exercise $7.60 764,310 5,808,756 2,165,931 Oct 27, 2010, 06:06 PM
ALTA BIOPHARMA PARTNERS III LP 10% Owner Oct 27, 2010 Buy $9.50 315,789 2,999,996 2,455,167 Oct 27, 2010, 06:06 PM
Lewis William President, PFO and Treasurer Oct 27, 2010 Option Exercise $7.60 35,006 266,046 108,966 Oct 27, 2010, 05:49 PM
Kiley Alison Director Oct 27, 2010 Option Exercise $7.60 764,310 5,808,756 2,364,762 Oct 27, 2010, 05:48 PM
Kiley Alison Director Oct 27, 2010 Buy $9.50 315,789 2,999,996 2,860,551 Oct 27, 2010, 05:48 PM
Index Venture Associates III Ltd 10% Owner Oct 27, 2010 Option Exercise $7.60 881,128 6,696,573 2,726,197 Oct 27, 2010, 05:46 PM
Index Venture Associates III Ltd 10% Owner Oct 27, 2010 Buy $9.50 315,789 2,999,996 3,041,986 Oct 27, 2010, 05:46 PM
FISHERMAN JASON S Director Oct 27, 2010 Option Exercise $7.60 2,286 17,374 7,109 Oct 27, 2010, 05:44 PM
FISHERMAN JASON S Director Oct 27, 2010 Option Exercise $7.60 2,286 17,374 4,823 Oct 27, 2010, 05:44 PM
FISHERMAN JASON S Director Oct 27, 2010 Buy $9.50 739 7,021 7,848 Oct 27, 2010, 05:44 PM
FISHERMAN JASON S Director Oct 27, 2010 Buy $9.50 739 7,021 7,109 Oct 27, 2010, 05:44 PM
Beer Marc D Chief Executive Officer Oct 27, 2010 Buy $9.50 105,263 999,999 105,263 Oct 27, 2010, 05:43 PM
Ollier Michele Director Oct 27, 2010 Option Exercise $7.60 881,128 6,696,573 2,730,369 Oct 27, 2010, 05:42 PM
Ollier Michele Director Oct 27, 2010 Buy $9.50 315,789 2,999,996 3,046,158 Oct 27, 2010, 05:42 PM
Advent Partners HLS III Limited Partnership Oct 27, 2010 Option Exercise $7.60 8,952 68,035 27,841 Oct 27, 2010, 05:40 PM
Advent Partners HLS III Limited Partnership Oct 27, 2010 Buy $9.50 2,895 27,503 30,736 Oct 27, 2010, 05:40 PM
Advent Healthcare & Life Sciences III-A Limited Partnership Member of Group > 10% Oct 27, 2010 Option Exercise $7.60 478,852 3,639,275 1,483,987 Oct 27, 2010, 05:39 PM
Advent Healthcare & Life Sciences III-A Limited Partnership Member of Group > 10% Oct 27, 2010 Option Exercise $7.60 478,852 3,639,275 1,005,135 Oct 27, 2010, 05:39 PM
Advent Healthcare & Life Sciences III-A Limited Partnership Member of Group > 10% Oct 27, 2010 Buy $9.50 154,790 1,470,505 1,483,987 Oct 27, 2010, 05:39 PM
Advent Healthcare & Life Sciences III-A Limited Partnership Member of Group > 10% Oct 27, 2010 Buy $9.50 154,790 1,470,505 1,638,777 Oct 27, 2010, 05:39 PM
ADVENT HEALTHCARE & LIFE SCIENCES III LIMITED PARTNERSHIP Member of Group > 10% Oct 27, 2010 Option Exercise $7.60 326,288 2,479,789 684,836 Oct 27, 2010, 05:37 PM
ADVENT HEALTHCARE & LIFE SCIENCES III LIMITED PARTNERSHIP Member of Group > 10% Oct 27, 2010 Option Exercise $7.60 326,288 2,479,789 1,011,124 Oct 27, 2010, 05:37 PM
ADVENT HEALTHCARE & LIFE SCIENCES III LIMITED PARTNERSHIP Member of Group > 10% Oct 27, 2010 Buy $9.50 105,473 1,001,994 1,011,124 Oct 27, 2010, 05:37 PM
ADVENT HEALTHCARE & LIFE SCIENCES III LIMITED PARTNERSHIP Member of Group > 10% Oct 27, 2010 Buy $9.50 105,473 1,001,994 1,116,597 Oct 27, 2010, 05:37 PM
AHLS III GP LIMITED PARTNERSHIP Member of Group > 10% Oct 27, 2010 Option Exercise $7.60 805,140 6,119,064 1,689,971 Oct 27, 2010, 05:36 PM
AHLS III GP LIMITED PARTNERSHIP Member of Group > 10% Oct 27, 2010 Option Exercise $7.60 805,140 6,119,064 2,495,111 Oct 27, 2010, 05:36 PM
AHLS III GP LIMITED PARTNERSHIP Member of Group > 10% Oct 27, 2010 Buy $9.50 260,263 2,472,499 2,755,374 Oct 27, 2010, 05:36 PM
AHLS III GP LIMITED PARTNERSHIP Member of Group > 10% Oct 27, 2010 Buy $9.50 260,263 2,472,499 2,495,111 Oct 27, 2010, 05:36 PM
ADVENT INTERNATIONAL LLC Member of Group > 10% Oct 27, 2010 Option Exercise $7.60 805,140 6,119,064 2,495,111 Oct 27, 2010, 05:35 PM
ADVENT INTERNATIONAL LLC Member of Group > 10% Oct 27, 2010 Option Exercise $7.60 805,140 6,119,064 1,689,971 Oct 27, 2010, 05:35 PM
ADVENT INTERNATIONAL LLC Member of Group > 10% Oct 27, 2010 Buy $9.50 260,263 2,472,499 2,755,374 Oct 27, 2010, 05:35 PM
ADVENT INTERNATIONAL LLC Member of Group > 10% Oct 27, 2010 Buy $9.50 260,263 2,472,499 2,495,111 Oct 27, 2010, 05:35 PM
ADVENT INTERNATIONAL CORP/MA Member of Group > 10% Oct 27, 2010 Option Exercise $7.60 814,092 6,187,099 2,522,952 Oct 27, 2010, 05:34 PM
ADVENT INTERNATIONAL CORP/MA Member of Group > 10% Oct 27, 2010 Option Exercise $7.60 814,092 6,187,099 1,708,860 Oct 27, 2010, 05:34 PM
ADVENT INTERNATIONAL CORP/MA Member of Group > 10% Oct 27, 2010 Buy $9.50 263,158 2,500,001 2,522,952 Oct 27, 2010, 05:34 PM
ADVENT INTERNATIONAL CORP/MA Member of Group > 10% Oct 27, 2010 Buy $9.50 263,158 2,500,001 2,786,110 Oct 27, 2010, 05:34 PM
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Buy Sale Option Exercise
Owner Relationship Date Value($)
Harshbarger Benjamin General Counsel 09/17/2016 947
Harshbarger Benjamin General Counsel 04/01/2016 969
Broadfin Healthcare Master Fund Ltd 10% Owner 09/13/2016 131,250
Broadfin Healthcare Master Fund Ltd 10% Owner 09/12/2016 298,800
Broadfin Healthcare Master Fund Ltd 10% Owner 09/09/2016 159,500
SMITH SANDFORD D Director 07/27/2016 1,204
Broadfin Healthcare Master Fund Ltd 10% Owner 03/18/2016 3,732,000
Broadfin Healthcare Master Fund Ltd 10% Owner 03/17/2016 18,000
SMITH SANDFORD D Director 01/27/2016 5,275
Broadfin Healthcare Master Fund Ltd 10% Owner 11/11/2015 439,649
Fitzpatrick Mark J. Chief Financial Officer 08/19/2014 35,236
Beer Marc D Chief Executive Officer 07/31/2014 336,539
Beer Marc D Chief Executive Officer 06/03/2014 301,200
Beer Marc D Chief Executive Officer 05/27/2014 315,900
Beer Marc D Chief Executive Officer 05/21/2014 9,856
Beer Marc D Chief Executive Officer 05/20/2014 305,300
VANLENT ANNE Director 05/08/2014 135,110
Beer Marc D Chief Executive Officer 05/08/2014 1,059,300
Fraser Craig Pres., US/Int. Comm. & Manuf. 03/31/2014 29,273
Fraser Craig Pres., US/Int. Comm. & Manuf. 03/31/2014 103,947
Beer Marc D Chief Executive Officer 03/26/2014 4,620
Sumeray Mark Chief Medical Officer 03/14/2014 26,020
Sumeray Mark Chief Medical Officer 03/14/2014 102,670
Fitzpatrick Mark J. Chief Financial Officer 03/04/2014 44,100
Sumeray Mark Chief Medical Officer 02/14/2014 26,020
Sumeray Mark Chief Medical Officer 02/14/2014 126,970
Fitzpatrick Mark J. Chief Financial Officer 02/10/2014 132,300
Fraser Craig Pres., US/Int. Comm. & Manuf. 02/11/2014 29,273
Fraser Craig Pres., US/Int. Comm. & Manuf. 02/11/2014 150,750
Fitzpatrick Mark J. Chief Financial Officer 02/10/2014 469,543
Sumeray Mark Chief Medical Officer 01/16/2014 26,020
Sumeray Mark Chief Medical Officer 01/16/2014 117,269
Fraser Craig Pres., US/Int. Comm. & Manuf. 01/02/2014 29,273
Fraser Craig Pres., US/Int. Comm. & Manuf. 01/02/2014 159,998
Sumeray Mark Chief Medical Officer 01/02/2014 13,010
Sumeray Mark Chief Medical Officer 01/02/2014 70,934
Sumeray Mark Chief Medical Officer 12/16/2013 26,020
Sumeray Mark Chief Medical Officer 12/16/2013 132,687
Beer Marc D Chief Executive Officer 12/04/2013 6,745
Sumeray Mark Chief Medical Officer 12/02/2013 39,030
Sumeray Mark Chief Medical Officer 12/02/2013 211,267
Fraser Craig Pres., US/Int. Comm. & Manuf. 12/02/2013 29,273
Fraser Craig Pres., US/Int. Comm. & Manuf. 12/02/2013 158,423
Sumeray Mark Chief Medical Officer 11/15/2013 26,020
Sumeray Mark Chief Medical Officer 11/15/2013 152,182
Fitzpatrick Mark J. Chief Financial Officer 11/11/2013 182,574
Fitzpatrick Mark J. Chief Financial Officer 11/11/2013 592,829
Beer Marc D Chief Executive Officer 11/05/2013 60,060
Carter Martha J. Chief Regulatory Officer & SVP 11/01/2013 74,200
Carter Martha J. Chief Regulatory Officer & SVP 11/01/2013 414,050
Sumeray Mark Chief Medical Officer 11/01/2013 45,535
Sumeray Mark Chief Medical Officer 11/01/2013 291,481
Fraser Craig Pres., US/Int. Comm. & Manuf. 11/01/2013 29,273
Fraser Craig Pres., US/Int. Comm. & Manuf. 11/01/2013 187,275
Beer Marc D Chief Executive Officer 10/30/2013 61,600
Beer Marc D Chief Executive Officer 10/30/2013 3,511,665
SMITH SANDFORD D Director 10/29/2013 37,530
SMITH SANDFORD D Director 10/29/2013 237,690
Sumeray Mark Chief Medical Officer 10/15/2013 26,020
Sumeray Mark Chief Medical Officer 10/15/2013 160,659
Sumeray Mark Chief Medical Officer 10/07/2013 45,535
Sumeray Mark Chief Medical Officer 10/07/2013 326,086
Fraser Craig Pres., US/Int. Comm. & Manuf. 10/07/2013 260,200
Fraser Craig Pres., US/Int. Comm. & Manuf. 10/07/2013 1,863,146
Sumeray Mark Chief Medical Officer 09/16/2013 26,020
Sumeray Mark Chief Medical Officer 09/16/2013 179,549
PERCEPTIVE ADVISORS LLC 10% Owner 09/05/2013 66,899,998
PERCEPTIVE ADVISORS LLC 10% Owner 06/15/2013 5,000,000
Fitzpatrick Mark J. Chief Financial Officer 08/26/2013 44,100
Scheer David Director 08/21/2013 1,691,638
Sumeray Mark Chief Medical Officer 08/16/2013 26,020
Sumeray Mark Chief Medical Officer 08/16/2013 177,413
Fitzpatrick Mark J. Chief Financial Officer 08/14/2013 132,300
Fitzpatrick Mark J. Chief Financial Officer 08/14/2013 700,816
Beer Marc D Chief Executive Officer 08/15/2013 92,400
Beer Marc D Chief Executive Officer 08/15/2013 5,312,209
SMITH SANDFORD D Director 08/09/2013 160,518
SMITH SANDFORD D Director 08/09/2013 781,414
SMITH SANDFORD D Director 08/12/2013 141,791
Sumeray Mark Chief Medical Officer 07/15/2013 26,020
Sumeray Mark Chief Medical Officer 07/15/2013 157,546
Sumeray Mark Chief Medical Officer 06/17/2013 78,060
Sumeray Mark Chief Medical Officer 06/17/2013 391,620
Sumeray Mark Chief Medical Officer 05/15/2013 78,060
Sumeray Mark Chief Medical Officer 05/15/2013 283,930
Sumeray Mark Chief Medical Officer 04/22/2013 78,060
Sumeray Mark Chief Medical Officer 04/22/2013 244,451
PERCEPTIVE ADVISORS LLC 10% Owner 02/01/2013 1,389,400
Carter Martha J. Chief Regulatory Officer & SVP 01/23/2013 13,905
PERCEPTIVE ADVISORS LLC 10% Owner 01/18/2013 1,381,000
PERCEPTIVE ADVISORS LLC 10% Owner 01/17/2013 1,336,285
PERCEPTIVE ADVISORS LLC 10% Owner 01/11/2013 12,857,220
PERCEPTIVE ADVISORS LLC 10% Owner 12/04/2012 425,400
PERCEPTIVE ADVISORS LLC 10% Owner 11/29/2012 681,300
PERCEPTIVE ADVISORS LLC 10% Owner 11/07/2012 633,600
PERCEPTIVE ADVISORS LLC 10% Owner 11/28/2012 1,523,200
PERCEPTIVE ADVISORS LLC 10% Owner 11/21/2012 415,000
PERCEPTIVE ADVISORS LLC 10% Owner 11/20/2012 420,200
PERCEPTIVE ADVISORS LLC 10% Owner 11/15/2012 195,000
PERCEPTIVE ADVISORS LLC 10% Owner 10/19/2012 4,331,250
ALTA BIOPHARMA PARTNERS III LP 10% Owner 10/15/2012 975,680
ALTA BIOPHARMA PARTNERS III LP 10% Owner 10/16/2012 219,765
ALTA BIOPHARMA PARTNERS III LP 10% Owner 10/15/2012 89,577
ALTA BIOPHARMA PARTNERS III LP 10% Owner 10/16/2012 2,394,035
Carter Martha J. Chief Regulatory Officer 03/30/2012 14,030
Beer Marc D Chief Executive Officer 03/29/2012 13,735
Fitzpatrick Mark J. Chief Financial Officer 03/23/2012 7,076
Beer Marc D Chief Executive Officer 03/22/2012 13,964
ADVENT INTERNATIONAL CORP/MA Member of Group > 10% 03/09/2012 1,586,830
ADVENT INTERNATIONAL LLC Member of Group > 10% 03/09/2012 1,569,327
ADVENT HEALTHCARE & LIFE SCIENCES III LIMITED PARTNERSHIP Member of Group > 10% 03/09/2012 635,954
Advent Healthcare & Life Sciences III-A Limited Partnership Member of Group > 10% 03/09/2012 933,373
AHLS III GP LIMITED PARTNERSHIP Member of Group > 10% 03/09/2012 1,569,327
Advent Partners HLS III Limited Partnership Member of Group > 10% 03/09/2012 17,503
Index Venture Associates III Ltd 10% Owner 01/30/2012 854,000
AHLS III GP LIMITED PARTNERSHIP Member of Group > 10% 01/31/2012 377,156
AHLS III GP LIMITED PARTNERSHIP Member of Group > 10% 01/30/2012 45,563
AHLS III GP LIMITED PARTNERSHIP Member of Group > 10% 01/27/2012 848,800
Advent Partners HLS III Limited Partnership Member of Group > 10% 01/30/2012 512
Advent Partners HLS III Limited Partnership Member of Group > 10% 01/27/2012 9,475
Advent Partners HLS III Limited Partnership Member of Group > 10% 01/31/2012 4,207
ADVENT INTERNATIONAL LLC Member of Group > 10% 01/31/2012 377,156
ADVENT INTERNATIONAL LLC Member of Group > 10% 01/30/2012 45,563
ADVENT INTERNATIONAL LLC Member of Group > 10% 01/27/2012 848,800
ADVENT INTERNATIONAL CORP/MA Member of Group > 10% 01/30/2012 46,075
ADVENT INTERNATIONAL CORP/MA Member of Group > 10% 01/27/2012 858,275
ADVENT INTERNATIONAL CORP/MA Member of Group > 10% 01/31/2012 381,363
Advent Healthcare & Life Sciences III-A Limited Partnership Member of Group > 10% 01/31/2012 224,320
Advent Healthcare & Life Sciences III-A Limited Partnership Member of Group > 10% 01/30/2012 27,099
Advent Healthcare & Life Sciences III-A Limited Partnership Member of Group > 10% 01/27/2012 504,820
ADVENT HEALTHCARE & LIFE SCIENCES III LIMITED PARTNERSHIP Member of Group > 10% 01/31/2012 152,836
ADVENT HEALTHCARE & LIFE SCIENCES III LIMITED PARTNERSHIP Member of Group > 10% 01/30/2012 18,464
ADVENT HEALTHCARE & LIFE SCIENCES III LIMITED PARTNERSHIP Member of Group > 10% 01/27/2012 343,979
Advent Partners HLS III Limited Partnership Member of Group > 10% 12/09/2011 3,311
Advent Partners HLS III Limited Partnership Member of Group > 10% 12/08/2011 473
Advent Healthcare & Life Sciences III-A Limited Partnership 12/08/2011 24,836
Advent Healthcare & Life Sciences III-A Limited Partnership 12/09/2011 176,473
ADVENT HEALTHCARE & LIFE SCIENCES III LIMITED PARTNERSHIP 12/09/2011 120,244
ADVENT HEALTHCARE & LIFE SCIENCES III LIMITED PARTNERSHIP 12/08/2011 16,929
AHLS III GP LIMITED PARTNERSHIP 12/09/2011 296,717
AHLS III GP LIMITED PARTNERSHIP 12/08/2011 41,765
ADVENT INTERNATIONAL LLC 12/09/2011 296,717
ADVENT INTERNATIONAL LLC 12/08/2011 41,765
ADVENT INTERNATIONAL CORP/MA Member of Group > 10% 12/09/2011 300,028
ADVENT INTERNATIONAL CORP/MA Member of Group > 10% 12/08/2011 42,238
Advent Partners HLS III Limited Partnership Member of Group > 10% 12/06/2011 1,034
Advent Healthcare & Life Sciences III-A Limited Partnership Member of Group > 10% 12/06/2011 55,520
ADVENT HEALTHCARE & LIFE SCIENCES III LIMITED PARTNERSHIP Member of Group > 10% 12/06/2011 37,816
AHLS III GP LIMITED PARTNERSHIP Member of Group > 10% 12/06/2011 93,337
ADVENT INTERNATIONAL LLC Member of Group > 10% 12/06/2011 93,337
ADVENT INTERNATIONAL CORP/MA Member of Group > 10% 12/06/2011 94,371
Beer Marc D Chief Executive Officer 09/01/2011 21,904
Beer Marc D Chief Executive Officer 09/01/2011 77,733
Beer Marc D Chief Executive Officer 08/09/2011 98,849
Beer Marc D Chief Executive Officer 08/09/2011 21,438
Kiley Alison Director 08/09/2011 68,497
Kiley Alison Director 08/08/2011 52,204
ALTA BIOPHARMA PARTNERS III LP 10% Owner 08/09/2011 68,497
ALTA BIOPHARMA PARTNERS III LP 10% Owner 08/08/2011 52,204
Beer Marc D Chief Executive Officer 08/01/2011 21,910
Beer Marc D Chief Executive Officer 08/01/2011 77,724
Index Venture Associates III Ltd 10% Owner 07/29/2011 537,425
Ollier Michele Director 07/29/2011 537,425
Advent Partners HLS III Limited Partnership Member of Group > 10% 07/29/2011 833
Advent Healthcare & Life Sciences III-A Limited Partnership Member of Group > 10% 07/29/2011 44,045
ADVENT HEALTHCARE & LIFE SCIENCES III LIMITED PARTNERSHIP Member of Group > 10% 07/29/2011 30,006
AHLS III GP LIMITED PARTNERSHIP Member of Group > 10% 07/29/2011 74,051
ADVENT INTERNATIONAL LLC Member of Group > 10% 07/29/2011 74,051
ADVENT INTERNATIONAL CORP/MA Member of Group > 10% 07/29/2011 74,884
Index Venture Associates III Ltd 10% Owner 06/29/2011 12,822,392
Ollier Michele Director 06/29/2011 12,822,392
Advent Partners HLS III Limited Partnership Member of Group > 10% 06/29/2011 19,707
Advent Healthcare & Life Sciences III-A Limited Partnership Member of Group > 10% 06/29/2011 1,050,702
ADVENT HEALTHCARE & LIFE SCIENCES III LIMITED PARTNERSHIP Member of Group > 10% 06/29/2011 715,899
AHLS III GP LIMITED PARTNERSHIP Member of Group > 10% 06/29/2011 1,766,601
ADVENT INTERNATIONAL LLC Member of Group > 10% 06/29/2011 1,766,601
ADVENT INTERNATIONAL CORP/MA Member of Group > 10% 06/29/2011 1,786,308
Beer Marc D Chief Executive Officer 06/29/2011 999,998
Beer Marc D Chief Executive Officer 06/01/2011 21,914
Beer Marc D Chief Executive Officer 06/01/2011 77,788
Beer Marc D Chief Executive Officer 04/04/2011 21,916
Beer Marc D Chief Executive Officer 04/04/2011 77,744
Scheer David Director 03/10/2011 60,349
Scheer David Director 03/11/2011 92,252
Beer Marc D Chief Executive Officer 12/15/2010 2,465
Kiley Alison Director 10/27/2010 2,999,996
ALTA BIOPHARMA PARTNERS III LP 10% Owner 10/27/2010 5,808,756
ALTA BIOPHARMA PARTNERS III LP 10% Owner 10/27/2010 2,999,996
Lewis William President, PFO and Treasurer 10/27/2010 266,046
Kiley Alison Director 10/27/2010 5,808,756
Kiley Alison Director 10/27/2010 2,999,996
Index Venture Associates III Ltd 10% Owner 10/27/2010 6,696,573
Index Venture Associates III Ltd 10% Owner 10/27/2010 2,999,996
FISHERMAN JASON S Director 10/27/2010 17,374
FISHERMAN JASON S Director 10/27/2010 17,374
FISHERMAN JASON S Director 10/27/2010 7,021
FISHERMAN JASON S Director 10/27/2010 7,021
Beer Marc D Chief Executive Officer 10/27/2010 999,999
Ollier Michele Director 10/27/2010 6,696,573
Ollier Michele Director 10/27/2010 2,999,996
Advent Partners HLS III Limited Partnership 10/27/2010 68,035
Advent Partners HLS III Limited Partnership 10/27/2010 27,503
Advent Healthcare & Life Sciences III-A Limited Partnership Member of Group > 10% 10/27/2010 3,639,275
Advent Healthcare & Life Sciences III-A Limited Partnership Member of Group > 10% 10/27/2010 3,639,275
Advent Healthcare & Life Sciences III-A Limited Partnership Member of Group > 10% 10/27/2010 1,470,505
Advent Healthcare & Life Sciences III-A Limited Partnership Member of Group > 10% 10/27/2010 1,470,505
ADVENT HEALTHCARE & LIFE SCIENCES III LIMITED PARTNERSHIP Member of Group > 10% 10/27/2010 2,479,789
ADVENT HEALTHCARE & LIFE SCIENCES III LIMITED PARTNERSHIP Member of Group > 10% 10/27/2010 2,479,789
ADVENT HEALTHCARE & LIFE SCIENCES III LIMITED PARTNERSHIP Member of Group > 10% 10/27/2010 1,001,994
ADVENT HEALTHCARE & LIFE SCIENCES III LIMITED PARTNERSHIP Member of Group > 10% 10/27/2010 1,001,994
AHLS III GP LIMITED PARTNERSHIP Member of Group > 10% 10/27/2010 6,119,064
AHLS III GP LIMITED PARTNERSHIP Member of Group > 10% 10/27/2010 6,119,064
AHLS III GP LIMITED PARTNERSHIP Member of Group > 10% 10/27/2010 2,472,499
AHLS III GP LIMITED PARTNERSHIP Member of Group > 10% 10/27/2010 2,472,499
ADVENT INTERNATIONAL LLC Member of Group > 10% 10/27/2010 6,119,064
ADVENT INTERNATIONAL LLC Member of Group > 10% 10/27/2010 6,119,064
ADVENT INTERNATIONAL LLC Member of Group > 10% 10/27/2010 2,472,499
ADVENT INTERNATIONAL LLC Member of Group > 10% 10/27/2010 2,472,499
ADVENT INTERNATIONAL CORP/MA Member of Group > 10% 10/27/2010 6,187,099
ADVENT INTERNATIONAL CORP/MA Member of Group > 10% 10/27/2010 6,187,099
ADVENT INTERNATIONAL CORP/MA Member of Group > 10% 10/27/2010 2,500,001
ADVENT INTERNATIONAL CORP/MA Member of Group > 10% 10/27/2010 2,500,001
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